Title:
COMPOUNDS, COMPOSITIONS, METHODS OF SYNTHESIS, AND METHODS OF TREATMENT
Kind Code:
A1


Abstract:
The present disclosure relates to organic chemistry and in particular to a series of corticotropin releasing factor type-1 (CRF1) receptor ligand compounds and compositions, as well as methods of preparation and treatment.



Inventors:
Stehouwer, Jeff (Atlanta, GA, US)
Goodman, Mark M. (Atlanta, GA, US)
Klits, Clint (Atlanta, GA, US)
Nemeroff, Charles (Atlanta, GA, US)
Application Number:
13/873277
Publication Date:
10/31/2013
Filing Date:
04/30/2013
Assignee:
EMORY UNIVERSITY
Primary Class:
Other Classes:
424/1.81, 424/1.85, 514/185, 514/214.02, 514/249, 514/250, 540/476, 540/578, 544/225, 544/350
International Classes:
A61K51/04; C07D471/04; C07D471/14; C07F7/22
View Patent Images:



Primary Examiner:
SHAMEEM, GOLAM M
Attorney, Agent or Firm:
Patent Manager (Atlanta, GA, US)
Claims:
1. 1-24. (canceled)

25. A compound selected from the group consisting of: embedded image and a pharmaceutically acceptable salt of any of the foregoing comprising a label selected from the group consisting of: 2H, 3H, 11C, 13N, 14C, 32Cl, 13N, 18F, 75Br, 76Br, 123I, 124I, 125I, and 131I wherein: R1 is selected from the group consisting of embedded image R2 is selected from the group consisting of: H, alkyl, and haloalkyl; R4 is independently selected from the group consisting of: —H, —X, alkyl, haloalkyl, —OH, —O-alkyl, —O-haloalkyl, and —Sn(alkyl)3, wherein o is 1, 2, or 3; each R9 are independently selected from the group consisting of: H, halogen, alkyl, haloalkyl, and heteroalkyl; R10 is selected from the group consisting of: H, halogen, alkyl, haloalkyl, and heteroalkyl; R11 is selected from the group consisting of: embedded image R12 is selected from the group consisting of: H, —OH, —O-alkyl, alkyl, X, haloalkyl, and heteroalkyl; R13 is selected from the group consisting of: H, alkyl, haloalkyl, and heteroalkyl; R14 is selected from the group consisting of: H, halogen, alkyl, haloalkyl, and heteroalkyl; R15 is selected from the group consisting of: H, halogen, alkyl, haloalkyl, and heteroalkyl; X is a halogen; X2 is selected from the group consisting of: H, alkyl, —X, and —Sn(alkyl)3; y is selected from the group consisting of: 1 or 2; and z is selected from the group consisting of: 1, 2, or 3.

26. The compound of formula (3), according to claim 25, wherein R9 is H and R10 is methyl, and a pharmaceutically acceptable salt of any of the foregoing.

27. The compound of formula (4), according to claim 25, wherein R9 is H and R10 is methyl, and a pharmaceutically acceptable salt of any of the foregoing.

28. The compound of formula (5), according to claim 25, wherein R9 is H and R10 is methyl, and a stereoisomer thereof, and a pharmaceutically acceptable salt of any of the foregoing.

29. A pharmaceutical composition comprising a compound of any one of claim 25 or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.

Description:

CROSS-REFERENCE TO RELATED APPLICATION

This application claims priority to U.S. provisional application entitled “COMPOUNDS, COMPOSITIONS, METHODS OF SYNTHESIS, AND METHODS OF TREATMENT,” having Ser. No. 61/154,146, filed on Feb. 20, 2009, which is entirely incorporated herein by reference.

TECHNICAL FIELD

The present disclosure relates to organic chemistry and in particular to a series of corticotropin releasing factor type-1 (CRF1) receptor ligand compounds and compositions, as well as methods of preparation and treatment.

BACKGROUND

Corticotropin releasing factor (CRF) is a peptide comprised of 41 amino acids. Vale et al. Science (1981) 213:1394. It is secreted by the hypothalamus, serving to coordinate the neuroendocrine response to stress by the hypothalamic-pituitary-adrenal (HPA) axis. Dunn et al. Brain Res. Rev. (1990) 15:71. As well as its role at the pituitary gland, CRF has demonstrated broad extrahypothalamic distribution in the central nervous system, producing a wide variety of autonomic, electrophysiological, and behavioral effects consistent with a neurotransmitter or neuromodulator role in the brain. Vale et al. Rec. Prog. Horm. Res. (1981) 39:245; Koob et al. Persp. Behay. Med. (1985) 2:39. De Souza (1985) 5:3189. CRF has been implicated in the pathophysiology of depression and other affective disorders which, in turn, has led to research of CRF1 antagonists. Arborelius et al. J. Endocrinol. (1999) 160:1; Kasckow et al. Peptides (2001) 22:845; Nemeroff et al. Science (1984) 226:1342; Gilligan et al. J. Med. Chem. (2000) 43:1641; Grigoriadis et al. Curr. Med. Chem.—CNS Agents (2001) 1:63; Owens et al. CNS Drugs (1999) 12:85; Keck et al. Peptides (2001) 22:835; Arzt et al. Trends Pharmacol. Sci. (2006) 27:531.

Administration of CRF directly to the brain elicits behavioral, physiological, and endocrine responses identical to those observed for an animal exposed to a stressful environment. Accordingly, clinical data suggests that CRF receptor antagonists may be useful in the treatment of the neuropsychiatric disorders manifesting hypersecretion of CRF, and, in particular, may represent novel antidepressant and/or anxiolytic drugs. The first CRF receptor antagonists were peptides. U.S. Pat. No. 4,605,642; Rivier et al., Science (1984) 224:889. While these peptides established that CRF receptor antagonists can attenuate the pharmacological responses to CRF, peptide CRF receptor antagonists suffer from the usual drawbacks of peptide therapeutics including lack of stability and limited oral activity. More recently, small molecule CRF receptor antagonists have been reported. Because of the physiological significance of CRF, biologically-active, small molecules having significant CRF receptor binding activity are thought to be useful in the treatment of endocrine, psychiatric and neurologic conditions or illnesses, including stress-related disorders in general.

In fact, CRF has been implicated in a variety of diseases to date, as indicated by the following publications. It was reported that elevated concentrations of CRF in the cerebrospinal fluid of patients with major depression compared with healthy individuals; CRF-mRNA levels in the hypothalamus of depressive patients are higher than that of healthy individuals; and CRF receptors in cerebral cortex are reduced in suicide victims; plasma ACTH increase is diminished with administration of CRF to depressive patients. Journal of Endocrinology (1999) 160:1. CRF levels in the cerebrospinal fluid of some anxiety patients with obsessive-compulsive disorder, posttraumatic stress disorder or Tourette's syndrome are higher than in that of healthy individuals. Journal of Endocrinology (1999) 160:1. Plasma ACTH increase is diminished with administration of CRF to panic disorder patients. Exp. Clin. Endcrinol. Diabetes (1997) 105:65. Anxiety behavior has been observed in experimental animals by intracerebral administration of CRF. In addition, anxiety behavior is observed more frequently in CRF overexpressing mice than in normal mice. Journal of Endocrinology (1999) 160:1. CRF levels in the locus coeruleus are reduced by administration of anxiolytics. Exp. Clin. Endocrinol. Diabetes (1997) 105:65. Also, α-helical CRF(9-41), a peptide CRF antagonist, exhibits an antianxiety action in animal models. Brain Res. (1990) 509:80; Regulatory Peptides (1987) 18:37; J. Neurosci. (1994) 14:2579. Abnormal behavior withdrawal from alcohol or addictive drugs such as cocaine are inhibited by α-helical CRF(9-41), a peptide CRF antagonist Psychopharmacology (1991) 103:227.

CRF inhibits sexual behavior in rats. Nature (1983) 305:232. CRF reduces sleep in rats and is thus implicated the involvement in sleep disorder. Pharmacol. Biochem. Behay. (1987) 26:699. α-helical CRF(9-41), a peptide CRF antagonist, suppresses brain damage or electroencephalogram disturbances due to brain ischemia or NMDA receptor activation. TIPS (1996) 17:166. CRF elicits electroencephalogram and induces convulsions. Brain Res. (1983) 278:332. Cerebrospinal CRF levels are elevated in schizophrenic patients compared with healthy individuals. Am. J. Psychiatry (1987) 144:873. CRF content in the cerebral cortex is reduced in Alzheimer's disease patients, Parkinson's disease patients and progressive supranuclear palsy patients. Neurology (1987) 37, 905. CRF is reduced in the ganglia in Huntington's disease Neurology (1987) 37:905; Brain Res. (1987) 437:355. In addition, CRF administration has been found to enhance learning and memory in rats. Exp. Clin. Endcrinol. Diabetes (1997) 105:65.

CRF content in cerebrospinal fluid are reduced in amyotrophic lateral sclerosis patients. Oversecretion of ACTH and adrenocorticosteroids are exhibited in mice overexpressing CRF, these mice display abnormalities similar to Cushing's syndrome, including muscular atrophy, alopecia, and infertility. Endocrinology (1992) 130:3378. Cerebrospinal CRF is elevated in anorexia nervosa patients compared with healthy individuals, and plasma ACTH increase is low with administration of CRF to anorexia nervosa patients; and CRF suppress feeding in experimental animals. TIPS (1996) 17:166. Moreover, α-helical CRF(9-41), a peptide CRF antagonist, improves stress-induced hypophagia in animal models. Brain Res. Bull. (1986) 17:285. CRF has suppressed body weight gain in hereditary obese animals; a link has been suggested between low CRF levels and obesity syndrome; and the anorexic action and the body weight loss action of serotonin reuptake inhibitors has been possibly mediated by CRF release TIPS (1996) 17:166.

CRF acts centrally or peripherally to weaken gastric contraction and reduce gastric emptying Annals of the New York Academy of Sciences (1993) 697:233. Furthermore, reduced gastric function induced by abdominal surgery is recovered by α-helical CRF(9-41), a peptide CRF antagonist Am. J. Physiol. (1992) 262:G616. CRF promotes secretion of bicarbonate ion in the stomach, thereby lowering gastric acid secretion and suppressing cold restraint stress ulcers. Am. J. Physiol. (1990) 258:G152. Also, administration of CRF increases ulcers in non-restraint stress animals. Life Sci. (1989) 45:907. CRF suppresses small intestinal transit and promotes large intestinal transit, and defecation is induced. In addition, α-helical CRF(9-41), a peptide CRF antagonist, has a inhibiting action against restraint stress-induced gastric acid secretion, reduced gastric emptying, reduced small intestinal transit and promoted large intestinal transit. Gastroenterology (1988) 95:1510. Psychological stress in healthy individuals increases anxiety or sensations of gas and abdominal pain during colonic distension and CRF lowers the discomfort threshold. Gastroenterol. (1995) 109:1772; Neurogastroenterol. Mot. (1996) 8:9. Irritable bowel syndrome patients experience excessive acceleration of colonic motility with CRF administration compared to healthy individuals Gut (1998) 42:845.

Administration of CRF increases blood pressure, heart rate and body temperature, while α-helical CRF(9-41), a peptide CRF antagonist, suppresses stress-induced increases in blood pressure, heart rate and body temperature. J. Physiol. (1993) 460:221. CRF production is increased locally in inflammation sites in experimental animals and in the synovial fluid of rheumatic arthritis patients TIPS (1996) 17:166. CRF provokes degranulation of mast cells and promotes vascular permeability Endocrinology (1998) 139:403. CRF is detected in autoimmune thyroiditis patients Am. J. Pathol. (1994) 145:1159. Administration of CRF to experimental autoimmune encephalomyelitis rats has notably suppressed progression of symptoms such as paralysis. J. Immunol. (1997) 158:5751. Urocortin (a CRF analogue) has increased growth hormone secretion in a pituitary adenoma culture system from an acromegalia patient. Endocri. J. (1997) 44:627. Furthermore, CRF simulates secretion of cytokines such as interleukin-1 and interleukin-2 by leukocytes. J. Neuroimmunol. (1989) 23:256; Neurosci. Lett. (1990) 120:151. CRF administration and stress both suppress T lymphocyte proliferation and natural killer cell activity. α-helical CRF(9-41), a peptide CRF antagonist, improves the reduced function of these immune cells caused by CRF administration or stress. Endocrinology (1991) 128:1329. Breathing is notably increased by administration of CRF. Eur. J. Pharmacol. (1990) 182:405. Finally, aggravated breathing and insomnia have been observed as a result of CRF administration to elderly patients under chronic artificial respiration Acta Endocrinol. Copenh (1992) 127:200.

Thus, there is a need in the art for CRF antagonists.

SUMMARY

Briefly described, embodiments of this disclosure include compounds as described herein, labeled compounds as described herein, pharmaceutical composition including compounds described herein, methods of imaging, method of forming a compound as described herein, and the like. In particular, embodiments of the disclosure include a series of triamino-pyridine derivatives and labeled triamino-pyridine derivatives, methods of synthesizing these compounds, intermediate compounds, methods of treatment using these compounds, methods of imaging, diagnosing, localizing, monitoring, and/or assessing a condition (e.g., corticotropin releasing factor type-1 (CRF1)) and/or related biological events, using triamino-pyridine derivatives, and the like. In addition, the present disclosure includes compositions (e.g., labeled triamino-pyridine derivatives that are ligands for the CRF1 receptor) used in and methods relating to non-invasive imaging (e.g., positron emission tomography (PET) imaging or SPECT imaging).

One exemplary compound among others, includes: a compound selected from the group consisting of:

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as well as an atropisomer of each of these, a racemic mixture of each of these, and a stereoisomer of each of these, and a pharmaceutically acceptable salt of any of the foregoing, wherein:

    • R1 is selected from the group consisting of: —H, alkyl, alkenyl, haloalkyl, haloalkenyl,

embedded image

    • R2 is selected from the group consisting of: —H, alkyl, and haloalkyl;
    • each R3 is independently selected from the group consisting of: —H, —X, alkyl, haloalkyl, —OH, —O-alkyl, —O-haloalkyl, —NO2, —NH, —NH-alkyl, —N(alkyl)2, —N(alkyl)3OTf, —N(alkyl)3X, —Sn(alkyl)3, —SH, —S-alkyl, and —S-haloalkyl, wherein n is 1, 2, or 3 and wherein if n is 2 or 3, each R3 is chosen independently of any other R3;
    • each of R4, R5, and R6 (R5 and R6 are shown below) are each independently selected from the group consisting of: —H, —X, alkyl, haloalkyl, —OH, —O-alkyl, —O-haloalkyl, and —Sn(alkyl)3, wherein o, p, and q are each independently 1, 2, or 3 and wherein if any of o, p, or q are 2 or 3, each of R4, R5, and R6 are chosen independently of each other and any other R4, R5, and R6;
    • R7 is selected from the group consisting of: —H and alkyl;
    • R9 is selected from the group consisting of: —H, alkyl, alkenyl, benzyl, haloalkyl, haloalkenyl, and

embedded image

    • each R9 are independently selected from the group consisting of: —H, halogen, alkyl, haloalkyl, and heteroalkyl, each R9 is chosen independently of any other R9;
    • R10 is selected from the group consisting of: —H, halogen, alkyl, haloalkyl, and heteroalkyl;
    • R11 is selected from the group consisting of:

embedded image

    • R12 is selected from the group consisting of: —H, —OH, —O-alkyl, alkyl, X, haloalkyl, and heteroalkyl;
    • R13 is selected from the group consisting of: —H, alkyl, haloalkyl, and heteroalkyl;
    • R14 is selected from the group consisting of: —H, halogen, alkyl, haloalkyl, and heteroalkyl;
    • R15 is selected from the group consisting of: —H, halogen, alkyl, haloalkyl, and heteroalkyl;
    • X is a halogen
    • X2 is selected from the group consisting of: —H, alkyl, —X, and —Sn(alkyl)3;
    • y is selected from the group consisting of: 1 or 2; and
    • z is selected from the group consisting of: 1, 2, or 3;

with the proviso that for formula (I), when R11 is

embedded image

R1 is butyl and R2 is ethyl, R3 is not: 2-Br-4-i-Pr; 2,4-Cl; 2,4,6-CH3; 2-Cl-4-OCH3; or 2-CH3-4-OCH3.

One exemplary compound, among others, includes: a labeled compound of any one of the compounds of described above and herein, where the label is selected from the group consisting of: 2H, 3H, 11C, 13C, 14C, 32Cl, 13N, 18F, 75Br, 76Br, 123I, 124I, 125I, and 131I.

One exemplary pharmaceutical composition, among others, includes: a composition including any of the compositions described above or herein a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier. In an embodiment, the compound can be a labeled compound.

One exemplary method of imaging, among others, includes: contacting or administering to a tissue, cells, or a host a labeled compound described above or herein, and imaging the tissue, cells, or host, with an imaging system.

One exemplary method of diagnosing the presence of CRF1 related disease or condition or related biological events in a tissue, cells, or a host, among others, includes: contacting or administering to a tissue, cells, or a host, a labeled compound described above or herein; and imaging the tissue, cells, or a host with an imaging system, wherein the location of the labeled compound corresponds to the location of the CRF1 related disease or condition or related biological events.

One exemplary composition, among others, includes: a compound selected from the group consisting of:

embedded image

wherein X is a halogen; R1 is selected from the group consisting of: —H, alkyl, alkenyl, haloalkyl, haloalkenyl,

embedded image

R2 is selected from the group consisting of: —H, alkyl, and haloalkyl; wherein R12 is selected from the group consisting of: —H, —OH, —O-alkyl, alkyl, X, haloalkyl, and heteroalkyl; wherein R13 is selected from the group consisting of: —H, alkyl, haloalkyl, and heteroalkyl; wherein R14 is selected from the group consisting of: —H, halogen, alkyl, haloalkyl, and heteroalkyl.

One exemplary composition, among others, includes: reacting

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in the presence of a haloacetyl halide or a haloacetic anhydride to form

embedded image

wherein X is a halogen; R1 is selected from the group consisting of: —H, alkyl, alkenyl, haloalkyl, haloalkenyl,

embedded image

R2 is selected from the group consisting of: —H, alkyl, and haloalkyl; wherein R12 is selected from the group consisting of: —H, —OH, —O-alkyl, alkyl, X, haloalkyl, and heteroalkyl; wherein R13 is selected from the group consisting of: —H, alkyl, haloalkyl, and heteroalkyl; wherein R14 is selected from the group consisting of: —H, halogen, alkyl, haloalkyl, and heteroalkyl.

DRAWINGS

Many aspects of this disclosure can be better understood with reference to the following drawings. The components in the drawings are not necessarily to scale, emphasis instead being placed upon clearly illustrating the principles of the present disclosure.

FIG. 1 depicts an H NMR spectra demonstrating diastereotopic splitting due to atropisomerism.

FIG. 2 depicts a thermal ellipsoid representation of the X-ray crystal structure of compound number 8374.HCl (Table 8, R1=Bu, R2=Et, R6=H, R7=H).

FIG. 3 depicts a thermal ellipsoid representation of the X-ray crystal structure of XXXII.

FIG. 4 depicts a thermal ellipsoid representation of the X-ray crystal structure of XXXIII.

DETAILED DESCRIPTION

This disclosure is not limited to particular embodiments described, and as such may, of course, vary. The terminology used herein serves the purpose of describing particular embodiments only, and is not intended to be limiting, since the scope of the present disclosure will be limited only by the appended claims.

Where a range of values is provided, each intervening value, to the tenth of the unit of the lower limit unless the context clearly dictates otherwise, between the upper and lower limit of that range and any other stated or intervening value in that stated range, is encompassed within the disclosure. The upper and lower limits of these smaller ranges may independently be included in the smaller ranges and are also encompassed within the disclosure, subject to any specifically excluded limit in the stated range. Where the stated range includes one or both of the limits, ranges excluding either or both of those included limits are also included in the disclosure.

Ratios, concentrations, amounts, and other numerical data may be expressed herein in a range format. Such a range format is used for convenience and brevity, and thus, should be interpreted in a flexible manner to include not only the numerical values explicitly recited as the limits of the range, but also to include all the individual numerical values or sub-ranges encompassed within that range as if each numerical value and sub-range is explicitly recited. For illustration purposes only, a concentration range of “about 0.1% to about 5%” should be interpreted to include not only the explicitly recited concentration of about 0.1 wt % to about 5 wt %, but also include individual concentrations (e.g., 1%, 2%, 3%, and 4%) and the sub-ranges (e.g., 0.5%, 1.1%, 2.2%, 3.3%, and 4.4%) within the indicated range. The term “about” can include ±1%, ±2%, ±3%, ±4%, ±5%, ±6%, ±7%, ±8%, ±9%, or ±10%, or more of the numerical value(s) being modified.

As will be apparent to those of skill in the art upon reading this disclosure, each of the individual embodiments described and illustrated herein has discrete components and features which may be readily separated from or combined with the features of any of the other several embodiments without departing from the scope or spirit of the present disclosure. Any recited method may be carried out in the order of events recited or in any other order that is logically possible.

Embodiments of the present disclosure will employ, unless otherwise indicated, techniques of medicine, organic chemistry, biochemistry, molecular biology, pharmacology, and the like, which are within the skill of the art. Such techniques are explained fully in the literature.

Each of the applications and patents cited in this text, as well as each document or reference cited in each of the applications and patents (including during the prosecution of each issued patent; “application cited documents”), and each of the PCT and foreign applications or patents corresponding to and/or claiming priority from any of these applications and patents, and each of the documents cited or referenced in each of the application cited documents, are hereby expressly incorporated herein by reference. Further, documents or references cited in this text, in a Reference List before the claims, or in the text itself; and each of these documents or references (“herein cited references”), as well as each document or reference cited in each of the herein-cited references (including any manufacturer's specifications, instructions, etc.) are hereby expressly incorporated herein by reference.

Prior to describing the various embodiments, the following definitions are provided and should be used unless otherwise indicated.

DEFINITIONS

Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art of molecular biology, medicinal chemistry, and/or organic chemistry. Although methods and materials similar or equivalent to those described herein can be used in the practice or testing of the present disclosure, suitable methods and materials are described herein.

As used in the specification and the appended claims, the singular forms “a,” “an,” and “the” may include plural referents unless the context clearly dictates otherwise. Thus, for example, reference to “a support” includes a plurality of supports. In this specification and in the claims that follow, reference will be made to a number of terms that shall be defined to have the following meanings unless a contrary intention is apparent.

As used herein, “alkyl” or “alkyl group” refers to a saturated aliphatic hydrocarbon radical which may be straight or branched, having 1 to 20 carbon atoms, wherein the stated range of carbon atoms includes each intervening integer individually, as well as sub-ranges. Examples of alkyl groups include, but are not limited to, methyl, ethyl, i-propyl, n-propyl, n-butyl, t-butyl, pentyl, hexyl, septyl, octyl, nonyl, decyl, and the like.

As used herein, “alkenyl” or “alkenyl group” refers to an aliphatic hydrocarbon radical which may be straight or branched, containing at least one carbon-carbon double bond, having 2 to 20 carbon atoms, wherein the stated range of carbon atoms includes each intervening integer individually, as well as sub-ranges. Examples of alkenyl groups include, but are not limited to, ethenyl, propenyl, n-butenyl, i-butenyl, 3-methylbut-2-enyl, n-pentenyl, heptenyl, octenyl, decenyl, and the like.

As used herein, “halo”, “halogen”, or “halogen radical” refers to a fluorine, chlorine, bromine, and iodine radicals. Further, when used in compound words, such as “haloalkyl” or “haloalkenyl”, “halo” refers to an alkyl or alkenyl radical in which one or more hydrogens are substituted by halogen radicals.

As used herein, “heteroalkyl” refers to an alkyl group as defined above, in which one or more carbon atoms are substituted by nitrogen, oxygen, phosphorus, or sulfur atoms. Examples of heteroalkyl groups include, but are not limited to, ethoxymethyl, cyano, 2,3-dioxyethyl, and the like.

The term “unit dosage form,” as used herein, refers to physically discrete units suitable as unitary dosages for human and/or animal subjects, each unit containing a predetermined quantity of a compound (e.g., an anti-viral compound, as described herein) calculated in an amount sufficient to produce the desired effect in association with a pharmaceutically acceptable diluent, carrier or vehicle. The specifications for unit dosage forms depend on the particular compound employed, the route and frequency of administration, and the effect to be achieved, and the pharmacodynamics associated with each compound in the host.

A “pharmaceutically acceptable excipient,” “pharmaceutically acceptable diluent,” “pharmaceutically acceptable carrier,” or “pharmaceutically acceptable adjuvant” means an excipient, diluent, carrier, and/or adjuvant that are useful in preparing a pharmaceutical composition that are generally safe, non-toxic and neither biologically nor otherwise undesirable, and include an excipient, diluent, carrier, and adjuvant that are acceptable for veterinary use and/or human pharmaceutical use. “A pharmaceutically acceptable excipient, diluent, carrier and/or adjuvant” as used in the specification and claims includes one and more such excipients, diluents, carriers, and adjuvants.

As used herein, a “pharmaceutical composition” is meant to encompass a composition suitable for administration to a subject, such as a mammal, especially a human. In general a “pharmaceutical composition” is sterile, and preferably free of contaminants that are capable of eliciting an undesirable response within the subject (e.g., the compound(s) in the pharmaceutical composition is pharmaceutical grade). Pharmaceutical compositions can be designed for administration to subjects or patients in need thereof via a number of different routes of administration including oral, intravenous, buccal, rectal, parenteral, intraperitoneal, intradermal, intracheal, intramuscular, subcutaneous, inhalational and the like.

The term “therapeutically effective amount” as used herein refers to that amount of an embodiment of the agent (which may be referred to as a compound, an inhibitory agent, and/or a drug) being administered that will relieve to some extent one or more of the symptoms of the disease, i.e., infection, being treated, and/or that amount that will prevent, to some extent, one or more of the symptoms of the disease, i.e., infection, that the host being treated has or is at risk of developing.

“Pharmaceutically acceptable salt” refers to those salts that retain the biological effectiveness and optionally other properties of the free bases and that are obtained by reaction with inorganic or organic acids such as hydrochloric acid, hydrobromic acid, sulfuric acid, nitric acid, phosphoric acid, methanesulfonic acid, ethanesulfonic acid, p-toluenesulfonic acid, salicylic acid, malic acid, maleic acid, succinic acid, tartaric acid, citric acid, and the like.

In the event that embodiments of the disclosed agents form salts, these salts are within the scope of the present disclosure. Reference to an agent of any of the formulas herein is understood to include reference to salts thereof, unless otherwise indicated. The term “salt(s)”, as employed herein, denotes acidic and/or basic salts formed with inorganic and/or organic acids and bases. In addition, when an agent contains both a basic moiety and an acidic moiety, zwitterions (“inner salts”) may be formed and are included within the term “salt(s)” as used herein. Pharmaceutically acceptable (e.g., non-toxic, physiologically acceptable) salts are preferred, although other salts are also useful, e.g., in isolation or purification steps which may be employed during preparation. Salts of the compounds of an agent may be formed, for example, by reacting the agent with an amount of acid or base, such as an equivalent amount, in a medium such as one in which the salt precipitates or in an aqueous medium followed by lyophilization.

Embodiments of the agents that contain a basic moiety may form salts with a variety of organic and inorganic acids. Exemplary acid addition salts include acetates (such as those formed with acetic acid or trihaloacetic acid, for example, trifluoroacetic acid), adipates, alginates, ascorbates, aspartates, benzoates, benzenesulfonates, bisulfates, borates, butyrates, citrates, camphorates, camphorsulfonates, cyclopentanepropionates, digluconates, dodecylsulfates, ethanesulfonates, fumarates, glucoheptanoates, glycerophosphates, hemisulfates, heptanoates, hexanoates, hydrochlorides (formed with hydrochloric acid), hydrobromides (formed with hydrogen bromide), hydroiodides, 2-hydroxyethanesulfonates, lactates, maleates (formed with maleic acid), methanesulfonates (formed with methanesulfonic acid), 2-naphthalenesulfonates, nicotinates, nitrates, oxalates, pectinates, persulfates, 3-phenylpropionates, phosphates, picrates, pivalates, propionates, salicylates, succinates, sulfates (such as those formed with sulfuric acid), sulfonates (such as those mentioned herein), tartrates, thiocyanates, toluenesulfonates such as tosylates, undecanoates, and the like.

Embodiments of the agents that contain an acidic moiety may form salts with a variety of organic and inorganic bases. Exemplary basic salts include ammonium salts, alkali metal salts such as sodium, lithium, and potassium salts, alkaline earth metal salts such as calcium and magnesium salts, salts with organic bases (for example, organic amines) such as benzathines, dicyclohexylamines, hydrabamines (formed with N,N-bis(dehydroabietyl)ethylenediamine), N-methyl-D-glucamines, N-methyl-D-glucamides, t-butyl amines, and salts with amino acids such as arginine, lysine, and the like.

Basic nitrogen-containing groups may be quaternized with agents such as lower alkyl halides (e.g., methyl, ethyl, propyl, and butyl chlorides, bromides and iodides), dialkyl sulfates (e.g., dimethyl, diethyl, dibutyl, and diamyl sulfates), long chain halides (e.g., decyl, lauryl, myristyl and stearyl chlorides, bromides and iodides), aralkyl halides (e.g., benzyl and phenethyl bromides), and others.

Solvates of the agents of the disclosure are also contemplated herein.

To the extent that the disclosed active compounds, and salts thereof, may exist in their tautomeric form, all such tautomeric forms are contemplated herein as part of the present disclosure.

All stereoisomers of the agents, such as those that may exist due to asymmetric carbons on the various substituents, including enantiomeric forms (which may exist even in the absence of asymmetric carbons) and diastereomeric forms, are contemplated within the scope of this disclosure. Individual stereoisomers of the compounds of the disclosure may, for example, be substantially free of other isomers, or may be admixed, for example, as racemates or with all other, or other selected, stereoisomers. The stereogenic centers of the compounds of the present disclosure can have the S or R configuration as defined by the IUPAC 1974 Recommendations.

The term “prodrug” refers to an inactive precursor of an agent that is converted into a biologically active form in vivo. Prodrugs are often useful because, in some situations, they may be easier to administer than the parent compound. They may, for instance, be bioavailable by oral administration whereas the parent compound is not. The prodrug may also have improved solubility in pharmaceutical compositions over the parent drug. A prodrug may be converted into the parent drug by various mechanisms, including enzymatic processes and metabolic hydrolysis. Harper, N.J. (1962). Drug Latentiation in Jucker, ed. Progress in Drug Research, 4:221-294; Morozowich et al. (1977). Application of Physical Organic Principles to Prodrug Design in E. B. Roche ed. Design of Biopharmaceutical Properties through Prodrugs and Analogs, APhA; Acad. Pharm. Sci.; E. B. Roche, ed. (1977). Bioreversible Carriers in Drug in Drug Design, Theory and Application, APhA; H. Bundgaard, ed. (1985) Design of Prodrugs, Elsevier; Wang et al. (1999) Prodrug approaches to the improved delivery of peptide drug, Curr. Pharm. Design. 5(4):265-287; Pauletti et al. (1997). Improvement in peptide bioavailability: Peptidomimetics and Prodrug Strategies, Adv. Drug. Delivery Rev. 27:235-256; Mizen et al. (1998). The Use of Esters as Prodrugs for Oral Delivery of β-Lactam antibiotics, Pharm. Biotech. 11:345-365; Gaignault et al. (1996). Designing Prodrugs and Bioprecursors I. Carrier Prodrugs, Pract. Med. Chem. 671-696; M. Asgharnejad (2000). Improving Oral Drug Transport Via Prodrugs, in G. L. Amidon, P. I. Lee and E. M. Topp, Eds., Transport Processes in Pharmaceutical Systems, Marcell Dekker, p. 185-218; Balant et al. (1990) Prodrugs for the improvement of drug absorption via different routes of administration, Eur. J. Drug Metab. Pharmacokinet., 15(2): 143-53; Balimane and Sinko (1999). Involvement of multiple transporters in the oral absorption of nucleoside analogues, Adv. Drug Delivery Rev., 39(1-3):183-209; Browne (1997). Fosphenyloin (Cerebyx), Clin. Neuropharmacol. 20(1): 1-12; Bundgaard (1979). Bioreversible derivatization of drugs—principle and applicability to improve the therapeutic effects of drugs, Arch. Pharm. Chemi. 86(1): 1-39; H. Bundgaard, ed. (1985) Design of Prodrugs, New York: Elsevier; Fleisher et al. (1996). Improved oral drug delivery: solubility limitations overcome by the use of prodrugs, Adv. Drug Delivery Rev. 19(2): 115-130; Fleisher et al. (1985). Design of prodrugs for improved gastrointestinal absorption by intestinal enzyme targeting, Methods Enzymol. 112: 360-81; Farquhar D, et al. (1983). Biologically Reversible Phosphate-Protective Groups, J. Pharm. Sci., 72(3): 324-325; Han, H. K. et al. (2000). Targeted prodrug design to optimize drug delivery, AAPS PharmSci., 2(1): E6; Sadzuka Y. (2000). Effective prodrug liposome and conversion to active metabolite, Curr. Drug Metab., 1(1):31-48; D. M. Lambert (2000) Rationale and applications of lipids as prodrug carriers, Eur. J. Pharm. Sci., 11 Suppl 2:S15-27; Wang, W. et al. (1999) Prodrug approaches to the improved delivery of peptide drugs. Curr. Pharm. Des., 5(4):265-87.

The term “administration” refers to introducing an agent of the present disclosure into a host. One preferred route of administration of the agents is oral administration. Another preferred route is intravenous administration. However, any route of administration, such as topical, subcutaneous, peritoneal, intraarterial, inhalation, vaginal, rectal, nasal, introduction into the cerebrospinal fluid, or instillation into body compartments can be used.

As used herein, the terms “treatment”, “treating”, and “treat” are defined as acting upon a disease, disorder, or condition with an agent (e.g., compound described herein) to reduce or ameliorate the pharmacologic and/or physiologic effects of the disease, disorder, or condition and/or its symptoms. “Treatment,” as used herein, covers any treatment of a disease in a host (e.g., a mammal, typically a human or non-human animal of veterinary interest), and includes: (a) reducing the risk of occurrence of the disease in a subject determined to be predisposed to the disease but not yet diagnosed as infected with the disease, (b) impeding the development of the disease, and (c) relieving the disease, i.e., causing regression of the disease and/or relieving one or more disease symptoms. “Treatment” is also meant to encompass delivery of an agent (e.g., compound described herein) to provide a pharmacologic effect, even in the absence of a disease or condition. For example, “treatment” encompasses delivery of an agent that provides for enhanced or desirable effects in the subject (e.g., reduction of disease symptoms, etc.).

As used herein, the terms “prophylactically treat” or “prophylactically treating” refers completely or partially (e.g., about 70% or greater, about 80% or greater, about 90% or greater, about 95% or greater) preventing a disease or symptom thereof and/or may be therapeutic in terms of a partial or complete cure for a disease and/or adverse effect attributable to the disease. The terms “treatment”, “treating”, and “treat” are distinguishable from the terms “prophylactically treat” or “prophylactically treating” as their definitions disclose and thereby have distinct meanings.

As used herein, the term “host,” “subject,” “patient,” or “organism” includes humans and mammals (e.g., mice, rats, pigs, cats, dogs, and horses). Typical hosts to which compounds of the present disclosure may be administered will be mammals, particularly primates, especially humans. For veterinary applications, a wide variety of subjects will be suitable, e.g., livestock such as cattle, sheep, goats, cows, swine, and the like; poultry such as chickens, ducks, geese, turkeys, and the like; and domesticated animals particularly pets such as dogs and cats. For diagnostic or research applications, a wide variety of mammals will be suitable subjects, including rodents (e.g., mice, rats, hamsters), rabbits, primates, and swine such as inbred pigs and the like. The term “living host” refers to a host noted above or another organism that is alive. The term “living host” refers to the entire host or organism and not just a part excised (e.g., a liver or other organ) from the living host.

Discussion:

The present disclosure provides compounds including a series of triamino-pyridine derivatives and labeled triamino-pyridine derivatives, methods of synthesizing these compounds, intermediate compounds, methods of treatment using these compounds, methods of imaging, diagnosing, localizing, monitoring, and/or assessing a condition (e.g., corticotropin releasing factor type-1 (CRF1)) and/or related biological events, using triamino-pyridine derivatives, and the like. In addition, the present disclosure includes compositions (e.g., labeled triamino-pyridine derivatives that are ligands for the CRF1 receptor) used in and methods relating to non-invasive imaging (e.g., positron emission tomography (PET) imaging or SPECT imaging).

Embodiments of the present disclosure include methods for imaging tissue, cells, or a host (e.g., a human or a mammal) that includes contacting with or administering to a tissue, cells, or host (e.g., human), labeled triamino-pyridine derivatives, and imaging the tissue with and imaging systems such as a PET imaging system or a SPECT system. The imaging can be performed in vivo and/or in vitro. In particular, embodiments of the present disclosure can be used to image CRF1 related diseases or conditions, or related biological events. In this regard, the tissue, cells, or host can be tested to determine if the tissue, cells, or host include a CRF1 related disease or condition or related biological events, monitor the progression (or regression) of the disease or condition, assess the response of the disease or condition to treatment, and the like. The tissue or cells can be within a host or have been removed from a host.

The CRF1 related diseases or conditions can include the following as well as or related biological events for any of these: depression and depressive symptoms such as major depression, single-episode depression, recurrent depression, depression-induced child abuse and postpartum depression, mania, anxiety, generalized anxiety disorder, panic disorder, phobia, obsessive-compulsive disorder, posttraumatic stress disorder, Tourette's syndrome, autism, affective disorder, dysthymia, bipolar disorder, cyclothymic personality, schizophrenia, Alzheimer's disease, senile dementia of Alzheimer's type, neurodegenerative disease such as Parkinson's disease and Huntington's disease, multi-infarct dementia, senile dementia, anorexia nervosa, hyperphagia and other eating disorders, obesity, diabetes, alcohol dependence, pharmacophilia for drugs such as cocaine, heroin or benzodiazepines, drug or alcohol withdrawal symptoms, sleep disorder, insomnia, migraine, stress-induced headache, muscle contraction induced headache, ischemic neuronal damage, excitotoxic neuronal damage, stroke, progressive supranuclear palsy, amyotrophic lateral sclerosis, multiple sclerosis, muscular spasm, chronic fatigue syndrome, psychosocial dwarfism, epilepsy, head trauma, spinal cord injury, cheirospasm, spasmodic torticollis, cervicobrachial syndrome, primary glaucoma, Meniere's syndrome, autonomic imbalance, alopecia, neuroses such as cardiac neurosis, gastric neurosis and bladder neurosis, peptic ulcer, irritable bowel syndrome, ulcerative colitis, Crohn's disease, diarrhea, constipation, postoperative ileus, stress-associated gastrointestinal disorders and nervous vomiting, hypertension, cardiovascular disorders such as angina pectoris nervosa, tachycardia, congestive heart failure, hyperventilation syndrome, bronchial asthma, apneusis, sudden infant death syndrome, inflammatory disorders (e.g., rheumatic arthritis, osteoarthritis, lumbago, etc.), pain, allergosis (e.g., atopic dermatitis, eczema, hives, psoriasis, etc.), impotence (erectile dysfunction), menopausal disorder, fertilization disorder, infertility, cancer, HIV infection-related immune dysfunction, stress-induced immune dysfunction, hemorrhagic stress, Cushing's syndrome, thyroid function disorder, encephalomyelitis, acromegaly, incontinence, osteoporosis, and the like. It should be noted that embodiments of the present disclosure contemplates that the CRF1 related diseases or conditions can include any one of the above or any combination of two or more of the above.

As noted above, embodiments of the present disclosure include triamino-pyridine derivatives such as optionally substituted 6-methyl-2,3,4-triamino-pyridine derivatives or labeled compounds thereof, designed as ligands for the corticotropin releasing factor type-1 (CRF1) receptor.

An embodiment of the present disclosure includes a compound according to either formula (1a)

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or (1 b;

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as well as atropisomers, racemic mixtures (racemate), and stereoisomers of any of the foregoing, and pharmaceutically acceptable salts of any of the foregoing, and labeled compounds of any of the foregoing, in which R1 is selected from the group consisting of: —H, alkyl, alkenyl, haloalkyl, haloalkenyl,

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R2 is selected from the group consisting of: —H, alkyl, and haloalkyl. Each of R9 and R10 are each independently selected from the group consisting of: —H, halogen, alkyl, haloalkyl, and heteroalkyl. In each instance of R9, each R9 can be independently selected from the other R9 moities of the formula.

R11 is selected from the group consisting of:

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Each R3 is independently selected from the group consisting of: —H, —X, alkyl, haloalkyl, —OH, —O-alkyl, —O-haloalkyl, —NO2, —NH, —NH-alkyl, —N(alkyl)2, —N(alkyl)3OTf, —N(alkyl)3X, —Sn(alkyl)3, —SH, —S-alkyl, and —S-haloalkyl. If n is 2 or 3, R3 is chosen independently of any other R3. Each of R4, R5, and R6 are each independently selected from the group consisting of: —H, —X, alkyl, haloalkyl, —OH, —O-alkyl, —O-haloalkyl, and —Sn(alkyl)3, in which n, o, p, and q are each independently 1, 2, or 3. If any of o, p, or q are 2 or 3, each of R4, R5, and R6 are chosen independently of each other and any other R4, R5, and R6. R7 is selected from the group consisting of: —H and alkyl. Each R4 can be independently selected from the other R4 groups. Each R5 can be independently selected from the other R5 groups. Each R6 can be independently selected from the other R6 groups.

R12 is selected from the group consisting of: —H, —OH, —O-alkyl, alkyl, X, haloalkyl, and heteroalkyl. R13 is selected from the group consisting of: H, alkyl, haloalkyl, and heteroalkyl. X represents a halogen moiety. X2 is selected from the group consisting of: —H, alkyl, —X, and —Sn(alkyl)3. R15 is selected from the group consisting of: —H, halogen, alkyl, haloalkyl, and heteroalkyl. R14 is selected from the group consisting of: —H, halogen, alkyl, haloalkyl, and heteroalkyl.

An embodiment of the present disclosure includes a compound according to formula (1), as well as atropisomers, racemic mixtures, and stereoisomers of any of the foregoing, and pharmaceutically acceptable salts of any of the foregoing, and labeled compounds of any of the foregoing, in which R1 is selected from the group consisting of: butyl, propyl, fluoropropyl, fluorobutyl, and FCH2—CH═CH—CH2. R2 is selected from the group consisting of: methyl, ethyl, propyl, fluoroethyl, and fluoropropyl. Each R3 is independently selected from the group consisting of: H, methyl, ethyl, propyl, butyl, iodo, chloro, fluoro, bromo, —CH2F, —CHF2, —CF3, —Sn(CH3)3, —OH, —OCH3, —OCF3, —OCH2F, —OCHF2, —OCH2CH2F, —OCH2CH2CH2F, —SH, —SCH3, —SCH2F, —SCH2CH2F, —SCH2CH2CH2F, —SCHF2, —SCF3, —NO2, —NH2, —NHCH3, —N(CH3)2, —N(CH3)3OTf (Tf is triflate), and —N(CH3)3I. R9 is H. R10 is methyl. R11 is

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The variable n is 1, 2, or 3. Each R3 can be independently selected from the other R3 groups.

An embodiment of the present disclosure includes a compound according to formula (VI),

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as well as atropisomers, racemic mixtures, and stereoisomers of any of the foregoing, and pharmaceutically acceptable salts of any of the foregoing, and labeled compounds of any of the foregoing, in which R1, R2, R3, and n are as previously defined. Each R3 can be independently selected from the other R3 groups.

An embodiment of the present disclosure includes a compound according to formula (1), as well as atropisomers, racemic mixtures, and stereoisomers of any of the foregoing, and pharmaceutically acceptable salts of any of the foregoing, and labeled compounds of any of the foregoing, in which R1 is selected from the group consisting of: butyl, propyl, fluoropropyl, fluorobutyl, and FCH2—CH═CH—CH2. R2 is selected from the group consisting of: methyl, ethyl, propyl, fluoroethyl, and fluoropropyl. R4 is independently selected from the group consisting of: H, methyl, ethyl, propyl, butyl, iodo, chloro, fluoro, bromo, —CF3, —Sn(CH3)3, —OH, —OCH3, —OCF3, —OCH2F, —OCHF2, —OCH2CH2F, and —OCH2CH2CH2F. In an embodiment R5 is H. R9 is H. R10 is methyl. R11 is

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The variable o is 1 or 2. The variable p is 1. X2 is selected from the group consisting of: H, methyl, iodo, chloro, bromo, fluoro, and Sn(CH3)3.

An embodiment of the present disclosure includes a compound according to formula (VII),

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as well as atropisomers, racemic mixtures, and stereoisomers of any of the foregoing, and pharmaceutically acceptable salts of any of the foregoing, and labeled compounds of any of the foregoing, in which R1, R2, R4, o, and X2 are as previously defined. Each R4 can be independently selected from the other R4 groups.

An embodiment of the present disclosure includes a compound according to formula (1), as well as atropisomers, racemic mixtures, and stereoisomers of any of the foregoing, and pharmaceutically acceptable salts of any of the foregoing, and labeled compounds of any of the foregoing, in which R1 is selected from the group consisting of: butyl, propyl, fluoropropyl, fluorobutyl, and FCH2—CH═CH—CH2. R2 is selected from the group consisting of: methyl, ethyl, propyl, fluoroethyl, and fluoropropyl. R11 is

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R9 is H. R10 is methyl. R4 is H. R5 is independently selected from the group consisting of: H, methyl, ethyl, propyl, butyl, iodo, chloro, fluoro, bromo, —CF3, —Sn(CH3)3, —OH, —OCH3, —OCF3, —OCH2F, —OCHF2, —OCH2CH2F, and —OCH2CH2CH2F. Each R5 can be independently selected from the other R5 groups. X2 is selected from the group consisting of: H, methyl, iodo, chloro, bromo, fluoro, and Sn(CH3)3. The variable o is 1. The variable p is 1 or 2.

An embodiment of the present disclosure includes a compound according to formula (VIII),

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as well as atropisomers, racemic mixtures, and stereoisomers of any of the foregoing, and pharmaceutically acceptable salts of any of the foregoing, and labeled compounds of any of the foregoing, in which R1, R2, R5, o, and X2 are as previously defined. Each R5 can be independently selected from the other R5 groups.

An embodiment of the present disclosure includes a compound according to formula (1), in which R1 is selected from the group consisting of: butyl, propyl, fluoropropyl, fluorobutyl, and FCH2—CH═CH—CH2. R2 is selected from the group consisting of: methyl, ethyl, propyl, fluoroethyl, and fluoropropyl. R6 is independently selected from the group consisting of: H, methyl, ethyl, propyl, butyl, iodo, chloro, fluoro, bromo, —Sn(CH3)3, —OH, —OCH3, —OCF3, —OCH2F, —OCHF2, —OCH2CH2F, and —OCH2CH2CH2F. R7 is H or methyl. R9 is H. R16 is methyl. R11 is

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The variable q is 1 or 2. Each R6 can be independently selected from the other R3 groups.

An embodiment of the present disclosure includes a compound according to formula (XIII),

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as well as atropisomers, racemic mixtures, and stereoisomers of any of the foregoing, and pharmaceutically acceptable salts of any of the foregoing, and labeled compounds of any of the foregoing, in which R1, R2, R6, R7, and q are as previously defined. Each R6 can be independently selected from the other R6 groups.

An embodiment of the present disclosure includes a compound according to formula (1), as well as atropisomers, racemic mixtures, and stereoisomers of any of the foregoing, and pharmaceutically acceptable salts of any of the foregoing, and labeled compounds of any of the foregoing, in which R1 is selected from the group consisting of:

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R2 is selected from the group consisting of: methyl, ethyl, propyl, fluoroethyl, and fluoropropyl. R9 is H. R10 is methyl.

R11 is

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R12, R13, and R14 are previously described above. Each R3 can be independently selected from the other R3 groups.

For any of the aforementioned embodiments pertaining to formula (1), when R11 is

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R1 is butyl and R2 is ethyl, R3 is not: 2-Br-4-Pr; 2,4-Cl; 2,4,6-CH3; 2-Cl-4-OCH3; or 2-CH3-4-OCH3. Put alternatively, when R11 is

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R1 is butyl, and R2 is ethyl, then R3 is not:

(1) bromine at the 2-position and iso-propyl at the 4-position;

(2) chlorine at the 2- and 4-positions;

(3) methyl at the 2-, 4-, and 6-positions;

(4) chlorine at the 2-position and methoxy at the 4-position; or

(5) methyl at the 2-position and methoxy at the 4-position.

An embodiment of the present disclosure includes a compound according to formula (XXXXI),

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as well as atropisomers, racemic mixtures, and stereoisomers of any of the foregoing, and pharmaceutically acceptable salts of any of the foregoing, and labeled compounds of any of the foregoing, in which R2, R3, R12, and n are as previously defined. Each R3 can be independently selected from the other R3 groups.

An embodiment of the present disclosure includes a compound according to formula (XXXXII),

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as well as atropisomers, racemic mixtures, and stereoisomers of any of the foregoing, and pharmaceutically acceptable salts of any of the foregoing, and labeled compounds of any of the foregoing, in which R2, R3, R12, R13, and n are as previously defined. Each R3 can be independently selected from the other R3 groups.

An embodiment of the present disclosure includes a compound according to formula (XXXXIII),

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as well as atropisomers, racemic mixtures, and stereoisomers of any of the foregoing, and pharmaceutically acceptable salts of any of the foregoing, and labeled compounds of any of the foregoing, in which R2, R3, R12, R13, and n are as previously defined. Each R3 can be independently selected from the other R3 groups.

An embodiment of the present disclosure includes a compound according to formula (1), as well as atropisomers, racemic mixtures, and stereoisomers of any of the foregoing, and pharmaceutically acceptable salts of any of the foregoing, and labeled compounds of any of the foregoing, in which R1 is selected from the group consisting of: butyl, propyl, fluoropropyl, fluorobutyl, and FCH2—CH═CH—CH2. R2 is selected from the group consisting of: methyl, ethyl, propyl, fluoroethyl, and fluoropropyl. R11 is selected from the group consisting of:

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where R12, R13, and R14 are as previously defined.

An embodiment of the present disclosure includes a compound according to formula (XXXVIII),

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as well as atropisomers, racemic mixtures, and stereoisomers of any of the foregoing, and pharmaceutically acceptable salts of any of the foregoing, and labeled compounds of any of the foregoing, wherein R1, R2, and R12 are as previously defined.

An embodiment of the present disclosure includes a compound according to formula (XXXIX),

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as well as atropisomers, racemic mixtures, and stereoisomers of any of the foregoing, and pharmaceutically acceptable salts of any of the foregoing, and labeled compounds of any of the foregoing, wherein R1, R2, R12, and R13 are as previously defined.

An embodiment of the present disclosure includes a compound according to formula (XXXIX),

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as well as atropisomers, racemic mixtures, and stereoisomers of any of the foregoing, and pharmaceutically acceptable salts of any of the foregoing, and labeled compounds of any of the foregoing, wherein R1, R2, R12, and R13 are as previously defined.

An embodiment of the present disclosure includes a compound according to formula (2),

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as well as atropisomers, racemic mixtures, and stereoisomers of any of the foregoing, and pharmaceutically acceptable salts of any of the foregoing, and labeled compounds of any of the foregoing, in which R1 is selected from the group consisting of: —H, alkyl, alkenyl, haloalkyl, and haloalkenyl. R2 is selected from the group consisting of: —H, alkyl, and haloalkyl. R9 and R10 are independently selected from the group consisting of: —H and alkyl. Each R9 can be independently selected from the other R9 moieties. R11 is selected from the group consisting of:

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X represents a halogen moiety. X2 is selected from the group consisting of: —H, alkyl, —X, and —Sn(alkyl)3.

Each R3 is independently selected from the group consisting of: —H, —X, alkyl, haloalkyl, —OH, —O-alkyl, —O-haloalkyl, —NO2, —NH, —NH-alkyl, —N(alkyl)2, —N(alkyl)3OTf, —N(alkyl)3X, —Sn(alkyl)3, —SH, —S-alkyl, and —S-haloalkyl, in which n is selected from the group consisting of: 1, 2, and 3. Each R3 can be independently selected from the other R3 groups. R4, R5, and R6 are each independently selected from the group consisting of: —H, —X, alkyl, haloalkyl, —OH, —O-alkyl, —O-haloalkyl, and —Sn(alkyl)3, in which o, p, and q are each independently 1, 2, or 3. R7 is selected from the group consisting of: —H and alkyl. Each R3 can be independently selected from the other R3 groups. Each R4 can be independently selected from the other R4 groups. Each R5 can be independently selected from the other R5 groups. Each R6 can be independently selected from the other R6 groups.

An embodiment of the present disclosure includes a compound according to formula (2), as well as atropisomers, racemic mixtures, and stereoisomers of any of the foregoing, and pharmaceutically acceptable salts of any of the foregoing, and labeled compounds of any of the foregoing, in which R1 is selected from the group consisting of: butyl, propyl, fluoropropyl, fluorobutyl, and FCH2—CH═CH—CH2. R2 is selected from the group consisting of: methyl, ethyl, propyl, fluoroethyl, and fluoropropyl. Each R3 is independently selected from the group consisting of: H, methyl, ethyl, propyl, butyl, iodo, chloro, fluoro, bromo, —CF3, —Sn(CH3)3, —OH, —OCH3, —OCF3, —OCH2F, —OCH2CH2F, —OCH2CH2CH2F, —SH, —SCH3, —SCH2F, —SCH2CH2F, —SCH2CH2CH2F, —SCF3, —NO2, —NH2, —NHCH3, —N(CH3)2, —N(CH3)3OTf, and —N(CH3)31. Each R3 can be independently selected from the other R3 groups. R9 is H. R10 is methyl. R11 is

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The variable n is 1, 2, or 3. Each R3 can be independently selected from the other R3 groups.

An embodiment of the present disclosure includes a compound according to formula (X),

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as well as atropisomers, racemic mixtures, and stereoisomers of any of the foregoing, and pharmaceutically acceptable salts of any of the foregoing, and labeled compounds of any of the foregoing, in which R1, R2, R3, and n are as previously defined. Each R3 can be independently selected from the other R3 groups.

An embodiment of the present disclosure includes a compound according to formula (2), as well as atropisomers, racemic mixtures, and stereoisomers of any of the foregoing, and pharmaceutically acceptable salts of any of the foregoing, and labeled compounds of any of the foregoing, in which R1 is selected from the group consisting of: butyl, propyl, fluoropropyl, fluorobutyl, and FCH2—CH═CH—CH2. R2 is selected from the group consisting of: methyl, ethyl, propyl, fluoroethyl, and fluoropropyl. R4 is independently selected from the group consisting of: H, methyl, ethyl, propyl, butyl, iodo, chloro, fluoro, bromo, —CF3, —Sn(CH3)3, —OH, —OCH3, —OCF3, —OCH2F, —OCHF2, —OCH2CH2F, and —OCH2CH2CH2F. Each R4 can be independently selected from the other R4 groups. R5 is H. R9 is H. R10 is methyl. R11 is

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The variable o is 1 or 2. The variable p is 1. X2 is selected from the group consisting of: H, methyl, iodo, chloro, bromo, fluoro, and Sn(CH3)3.

An embodiment of the present disclosure includes a compound according to formula (XI),

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as well as atropisomers, racemic mixtures, and stereoisomers of any of the foregoing, and pharmaceutically acceptable salts of any of the foregoing, and labeled compounds of any of the foregoing, in which R1, R2, R4, o, and X2 are as previously defined. Each R4 can be independently selected from the other R4 groups.

An embodiment of the present disclosure includes a compound according to formula (2), as well as atropisomers, racemic mixtures, and stereoisomers of any of the foregoing, and pharmaceutically acceptable salts of any of the foregoing, and labeled compounds of any of the foregoing, in which R1 is selected from the group consisting of: butyl, propyl, fluoropropyl, fluorobutyl, and FCH2—CH═CH—CH2. R2 is selected from the group consisting of: methyl, ethyl, propyl, fluoroethyl, and fluoropropyl. R11 is

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R9 is H. R10 is methyl. R4 is H. Each R5 is independently selected from the group consisting of: H, methyl, ethyl, propyl, butyl, iodo, chloro, fluoro, bromo, —CF3, —Sn(CH3)3, —OH, —OCH3, —OCF3, —OCH2F, —OCHF2—OCH2CH2F, and —OCH2CH2CH2F. Each R5 can be independently selected from the other R5 groups. X2 is selected from the group consisting of: H, methyl, iodo, chloro, bromo, fluoro, and Sn(CH3)3. The variable o is 1. The variable p is 1 or 2.

An embodiment of the present disclosure includes a compound according to formula (XII),

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as well as atropisomers, racemic mixtures, and stereoisomers of any of the foregoing, and pharmaceutically acceptable salts of any of the foregoing, and labeled compounds of any of the foregoing, in which R1, R2, R5, o, and X2 are as previously defined. Each R5 can be independently selected from the other R5 groups.

An embodiment of the present disclosure includes a compound according to formula (3),

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as well as atropisomers, racemic mixtures, and stereoisomers of any of the foregoing, and pharmaceutically acceptable salts of any of the foregoing, and labeled compounds of any of the foregoing, in which R1 is selected from the group consisting of: —H, alkyl, alkenyl, haloalkyl, and haloalkenyl. R2 is selected from the group consisting of: —H, alkyl, and haloalkyl. Each R4 is selected from the group consisting of: —H, —X, alkyl, haloalkyl, —OH, —O-alkyl, —O-haloalkyl, and —Sn(alkyl)3. Each R4 can be independently selected from the other R4 groups. R9 and R10 are independently selected from the group consisting of: —H and alkyl. Each R9 can be independently selected from the other R9 groups. The variables o and z are independently 1, 2, or 3. X represents a halogen moiety.

An embodiment of the present disclosure includes a compound according to formula (3), as well as atropisomers, racemic mixtures, and stereoisomers of any of the foregoing, and pharmaceutically acceptable salts of any of the foregoing, and labeled compounds of any of the foregoing, in which R1 is selected from the group consisting of: butyl, propyl, fluoropropyl, fluorobutyl, and FCH2—CH═CH—CH2. R2 is selected from the group consisting of: methyl, ethyl, propyl, fluoroethyl, and fluoropropyl. R4 is independently selected from the group consisting of: H, methyl, ethyl, propyl, butyl, iodo, chloro, fluoro, bromo, —CF3, —OH, —OCH3, —OCF3, —OCH2F, —OCHF2, —OCH2CH2F, and —OCH2CH2CH2F. R9 is H. R10 is methyl. The variable o is 1 or 2. The variable z is 1, 2, or 3.

An embodiment of the present disclosure includes a compound according to formulae

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as well as atropisomers, racemic mixtures, and stereoisomers of any of the foregoing, and pharmaceutically acceptable salts of any of the foregoing, and labeled compounds of any of the foregoing, in which R1, R2, R4, o, and z are as previously defined. Each R4 can be independently selected from the other R4 groups.

An embodiment of the present disclosure includes a compound according to formula (4),

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as well as atropisomers, racemic mixtures, and stereoisomers of any of the foregoing, and pharmaceutically acceptable salts of any of the foregoing, and labeled compounds of any of the foregoing, in which R3 is independently selected from the group consisting of: —H, —X, alkyl, haloalkyl, —OH, —O-alkyl, —O-haloalkyl, —NO2, —NH, —NH-alkyl, —N(alkyl)2, —N(alkyl)3OTf, —N(alkyl)3X, —Sn(alkyl)3, —SH, —S-alkyl, and —S-haloalkyl, in which n is 1, 2, or 3. Each R3 can be independently selected from the other R3 groups. R8 is selected from the group consisting of: —H, alkyl, alkenyl, haloalkyl, haloalkenyl, and

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R9 and R10 are independently selected from the group consisting of: —H and alkyl. X is a halogen moiety. R12 and R14 are described above. The variable y is 1 or 2.

An embodiment of the present disclosure includes a compound according to formula (4), as well as atropisomers, racemic mixtures, and stereoisomers of any of the foregoing, and pharmaceutically acceptable salts of any of the foregoing, and labeled compounds of any of the foregoing, in which R3 is independently selected from the group consisting of: H, methyl, ethyl, propyl, butyl, iodo, chloro, fluoro, bromo, —CH2F, —CHF2, —CF3, —Sn(CH3)3, —OH, —OCH3, —OCF3, —OCH2F, —OCHF2, —OCH2CH2F, —OCH2CH2CH2F, —SH, —SCH3, —SCH2F, —SCHF2, —SCH2CH2F, —SCH2CH2CH2F, —SCF3, —NO2, —NH2, —NHCH3, —N(CH3)2, —N(CH3)3OTf, and —N(CH3)31. Each R3 can be independently selected from the other R3 groups. R8 is selected from the group consisting of: H, methyl, ethyl, propyl, butyl, fluoromethyl, fluoroethyl, fluoropropyl, fluorobutyl, benzyl, FCH2—CH═CH—CH2, and

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R9 is H. R10 is methyl. The variable n is 1, 2, or 3. The variable y is 1 or 2. R12 and R14 are described above.

An embodiment of the present disclosure includes a compound according to formula (XIV),

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as well as atropisomers, racemic mixtures, and stereoisomers of any of the foregoing, and pharmaceutically acceptable salts of any of the foregoing, and labeled compounds of any of the foregoing, in which R3, R8, n, and y are as previously defined. Each R3 can be independently selected from the other R3 groups.

An embodiment of the present disclosure includes a compound according to formula (5),

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as well as atropisomers, racemic mixtures, and stereoisomers of any of the foregoing, and pharmaceutically acceptable salts of any of the foregoing, and labeled compounds of any of the foregoing, in which R3 is independently selected from the group consisting of: —H, —X, alkyl, haloalkyl, —OH, —O-alkyl, —O-haloalkyl, —NO2, —NH, —NH-alkyl, —N(alkyl)2, —N(alkyl)3OTf, —N(alkyl)3X, —Sn(alkyl)3, —SH, —S-alkyl, and —S-haloalkyl, in which n is selected from the group consisting of: 1, 2, and 3. Each R3 can be independently selected from the other R3 groups. R8 is selected from the group consisting of: —H, alkyl, alkenyl, haloalkyl, haloalkenyl, and

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R9 and R10 are independently selected from the group consisting of: —H and alkyl. X is a halogen moiety. R12 and R14 are described above.

An embodiment of the present disclosure includes a compound according to formula (5), as well as atropisomers, racemic mixtures, and stereoisomers of any of the foregoing, and pharmaceutically acceptable salts of any of the foregoing, and labeled compounds of any of the foregoing, in which R3 is independently selected from the group consisting of: H, methyl, ethyl, propyl, butyl, iodo, chloro, fluoro, bromo, —CH2F, —CHF2, —CF3, —Sn(CH3)3, —OH, —OCH3, —OCF3, —OCH2F, —OCHF2, —OCH2CH2F, —OCH2CH2CH2F, —SH, —SCH3, —SCH2F, —SCHF2, —SCH2CH2F, —SCH2CH2CH2F, —SCF3, —NO2, —NH2, —NHCH3, —N(CH3)2, —N(CH3)3OTf, and —N(CH3)31. Each R3 can be independently selected from the other R3 groups. R8 is selected from the group consisting of: H, methyl, ethyl, propyl, butyl, fluoromethyl, fluoroethyl, fluoropropyl, fluorobutyl, benzyl, FCH2—CH═CH—CH2, and

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R9 is H. R10 is methyl. R12 and R14 are described above. The variable n is 1, 2, or 3.

An embodiment of the present disclosure includes a compound according to formulae (XV),

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as well as atropisomers, racemic mixtures, and stereoisomers of any of the foregoing, and pharmaceutically acceptable salts of any of the foregoing, and labeled compounds of any of the foregoing, in which R3, R8, and n are as previously defined. Each R3 can be independently selected from the other R3 groups.

As described above, embodiments of the present disclosure include labeled triamino-pyridine derivatives such as labeled compounds of formulae (1), (2), (3), (4), (5), (VI), (VII), (VIII), (IXa), (IXb), (X), (XI), (XII), (XIII), (XIV), and (XV).

The labeled triamino-pyridine derivatives can be imaged using imaging systems such as positron emission tomography (PET) imaging systems, single photon emission computed tomography (SPECT), and the like. The PET and SPECT imaging systems are known in the art. In an embodiment, the labeled triamino-pyridine derivatives includes a label can be used to detect, image, or otherwise identify the labeled triamino-pyridine derivatives, quantify the amount of labeled triamino-pyridine derivatives, determine the location of the labeled triamino-pyridine derivatives (e.g., in imaging), and combinations thereof.

In an embodiment, the labeled triamino-pyridine derivative can include a radiolabel and/or a compound including a radiolabel. In an embodiment, the label is a radiolabel. In an embodiment, the radiolabel (e.g., non-radiolabels and their radiolabel counterparts) can include, but is not limited to, F-19 (F-18), C-12 (C-11), 1-127 (1-125, I-124, I-131, I-123), Cl-36 (Cl-32, Cl-33, Cl-34), and Br-80 (Br-74, Br-75, Br-76, Br-77, Br-78). It should be noted that an alternative way to represent F-18, C-11, and the like, is the following: 18F and 11C respectively, and both ways are used herein. In an embodiment, the radiolabel can be 2H, 3H, 11C, 13C, 14Cl, 32Cl, 13N, 18F, 75Br, 76Br, 123I, 124I, 125I, 131I. In an embodiment, the PET radiolabel can be 16F, 76Br, or 124I or 131I or combinations thereof. The SPECT isotope can include, but is not limited to, 123I, 125I, 131I, 99Tc, 111In, 186/188Re, or combinations thereof.

An embodiment of the present disclosure includes stereoisomers of triamino-pyridine derivatives including compounds according to any of the formulae previously described, which are enantiomers, diastereomers, atropisomers, conformers, racemic mixtures (racemate), and cis/trans isomers of these compounds.

An embodiment of the present disclosure includes compositions comprising triamino-pyridine derivatives or labeled triamino-pyridine derivatives, and stereoisomers of any of these, including a compound of formulae (1), (2), (3), (4), (5), (VI), (VII), (VIII), (IXa), (IXb), (X), (XI), (XII), (XIII), (XIV), and (XV) or a pharmaceutically acceptable salt thereof. An embodiment further comprises a pharmaceutically acceptable carrier.

Methods of Use

Embodiments of this disclosure include, but are not limited to: methods of imaging tissue, cells, or a host using labeled triamino-pyridine derivatives; methods of imaging an a CRF1 related disease or condition as described herein, or related biological events; methods of diagnosing a CRF1 related disease or condition or related biological events; methods of monitoring the progress of a CRF1 related disease or condition or related biological events, and the like.

Embodiments of the present disclosure can be used to image, detect, study, monitor, evaluate, assess, and/or screen, CRF1 related disease or condition or related biological events in vivo or in vitro using labeled triamino-pyridine derivatives.

In general, the labeled triamino-pyridine derivatives can be used in imaging CRF1 related diseases or conditions. For example, the labeled triamino-pyridine derivative is provided or administered to a host in an amount effective to result in uptake of the labeled triamino-pyridine derivative. After an appropriate amount of time, the host is then introduced to an appropriate imaging system (e.g., PET system) for a certain amount of time. The cell, tissue, and/or organ that takes-up the labeled triamino-pyridine derivative could be detected using the imaging system.

In an embodiment, the labeled triamino-pyridine derivative may find use both in diagnosing and/or in treating CRF, related diseases or conditions. In diagnosing the presence of CRF1 related diseases or conditions in a host, the labeled triamino-pyridine derivative is administered to the host in an amount effective to result in uptake of the labeled triamino-pyridine derivative. After administration of the labeled triamino-pyridine derivative, the labeled triamino-pyridine derivatives are detected using an appropriate imaging system. Embodiments of the present disclosure can non-invasively image CRF1 related diseases or conditions throughout an animal or human patient.

Embodiments of the labeled triamino-pyridine derivative can also find use in a host undergoing treatment, to aid in visualizing the response of CRF1 related diseases or conditions to the treatment. In this embodiment, the labeled triamino-pyridine derivative is typically visualized and sized prior to treatment, and periodically during treatment to monitor the CRF1 related diseases or conditions.

Embodiments of the labeled triamino-pyridine derivative also finds use as a screening tool in vitro to select compounds for use in treating CRF1 related diseases or conditions. The CRF1 related diseases or conditions could be easily monitored by incubating the cells with the labeled triamino-pyridine derivative during or after incubation with one or more candidate drugs. The ability of the drug compound to affect the binding of suitably labeled triamino-pyridine derivative will confer potency of the drug.

In addition, embodiments of this disclosure include methods of treating a host using labeled triamino-pyridine derivatives, where the host has or may have a CRF1 related disease or condition as described herein, or related biological events.

It should be noted that the amount effective to result in uptake of triamino-pyridine derivative or labeled triamino-pyridine derivative into the cells or tissue or organ of interest or the host will depend upon a variety of factors, including for example, the age, body weight, general health, sex, and diet of the host; the time of administration; the route of administration; the rate of excretion of the specific compound employed; the duration of the treatment; the existence of other drugs used in combination or coincidental with the specific composition employed; and like factors well known in the medical arts.

Kits

The present disclosure also provides packaged compositions or pharmaceutical compositions comprising a pharmaceutically acceptable carrier and triamino-pyridine derivative and/or the labeled triamino-pyridine derivative of the disclosure. In certain embodiments, the packaged compositions or pharmaceutical composition includes the reaction precursors to be used to generate the triamino-pyridine derivative and/or the labeled triamino-pyridine derivative according to the present disclosure. Other packaged compositions or pharmaceutical compositions provided by the present disclosure further include indicia including at least one of: instructions for using the composition to image a host, or host samples (e.g., cells or tissues), which can be used as an indicator of conditions including, but not limited to, CRF1 related diseases or conditions and biological related events. In embodiments, the kit may include instructions for using the composition or pharmaceutical composition to assess therapeutic effect of a drug protocol administered to a patient, instructions for using the composition to selectively image CRF1 related diseases or conditions, and instructions for using the composition to predict metastatic potential.

Embodiments of this disclosure encompass kits that include, but are not limited to, the triamino-pyridine derivative and/or the labeled triamino-pyridine derivative and directions (written instructions for their use). The components listed above can be tailored to the particular biological event to be monitored as described herein. The kit can further include appropriate buffers and reagents known in the art for administering various combinations of the components listed above to the host cell or host organism. The triamino-pyridine derivative and/or the labeled triamino-pyridine derivative and carrier may be provided in solution or in lyophilized form. When the triamino-pyridine derivative and/or the labeled triamino-pyridine derivative and carrier of the kit are in lyophilized form, the kit may optionally contain a sterile and physiologically acceptable reconstitution medium such as water, saline, buffered saline, and the like.

Pharmaceutical Formulations and Routes of Administration

Embodiments of the present disclosure include one or more triamino-pyridine derivative and/or the labeled triamino-pyridine derivatives identified herein and formulated with one or more pharmaceutically acceptable excipients, diluents, carriers and/or adjuvants. In addition, embodiments of the present disclosure include such triamino-pyridine derivative and/or the labeled triamino-pyridine derivatives formulated with one or more pharmaceutically acceptable auxiliary substances. In particular, one or more triamino-pyridine derivative and/or the labeled triamino-pyridine derivatives can be formulated with one or more pharmaceutically acceptable excipients, diluents, carriers, and/or adjuvants to provide an embodiment of a composition of the present disclosure.

A wide variety of pharmaceutically acceptable excipients are known in the art. Pharmaceutically acceptable excipients have been amply described in a variety of publications, including, for example, A. Gennaro (2000) “Remington: The Science and Practice of Pharmacy,” 20th edition, Lippincott, Williams, & Wilkins Pharmaceutical Dosage Forms and Drug Delivery Systems (1999) H. C. Ansel et al., eds., 7th ed., Lippincott, Williams, & Wilkins and Handbook of Pharmaceutical Excipients (2000) A. H. Kibbe et al., eds., 3rd ed. Amer. Pharmaceutical Assoc.

The pharmaceutically acceptable excipients, such as vehicles, adjuvants, carriers or diluents, are readily available to the public. Moreover, pharmaceutically acceptable auxiliary substances, such as pH adjusting and buffering agents, tonicity adjusting agents, stabilizers, wetting agents and the like, are readily available to the public.

In an embodiment of the present disclosure, the triamino-pyridine derivative and/or the labeled triamino-pyridine derivative is administered to the host using any means capable of resulting in the desired effect. Thus, the triamino-pyridine derivative and/or the labeled triamino-pyridine derivative can be incorporated into a variety of formulations for therapeutic administration. For example, the triamino-pyridine derivative and/or the labeled triamino-pyridine derivative can be formulated into pharmaceutical compositions by combination with appropriate, pharmaceutically acceptable carriers or diluents, and may be formulated into preparations in solid, semi-solid, liquid or gaseous forms, such as tablets, capsules, powders, granules, ointments, solutions, suppositories, injections, inhalants and aerosols.

In pharmaceutical dosage forms, the inhibiting agent may be administered in the form of its pharmaceutically acceptable salts, or a subject active agent may be used alone or in appropriate association, as well as in combination, with other pharmaceutically active compounds. The following methods and excipients are merely exemplary and are in no way limiting.

For oral preparations, the triamino-pyridine derivative and/or the labeled triamino-pyridine derivative can be used alone or in combination with appropriate additives to make tablets, powders, granules or capsules, for example, with conventional additives, such as lactose, mannitol, corn starch or potato starch; with binders, such as crystalline cellulose, cellulose derivatives, acacia, corn starch or gelatins; with disintegrators, such as corn starch, potato starch or sodium carboxymethylcellulose; with lubricants, such as talc or magnesium stearate; and if desired, with diluents, buffering agents, moistening agents, preservatives and flavoring agents.

Embodiments of the triamino-pyridine derivative and/or the labeled triamino-pyridine derivative can be formulated into preparations for injection by dissolving, suspending or emulsifying them in an aqueous or nonaqueous solvent, such as vegetable or other similar oils, synthetic aliphatic acid glycerides, esters of higher aliphatic acids or propylene glycol; and if desired, with conventional additives such as solubilizers, isotonic agents, suspending agents, emulsifying agents, stabilizers and preservatives.

Embodiments of the triamino-pyridine derivative and/or the labeled triamino-pyridine derivative can be utilized in aerosol formulation to be administered via inhalation. Embodiments of the triamino-pyridine derivative and/or the labeled triamino-pyridine derivative can be formulated into pressurized acceptable propellants such as dichlorodifluoromethane, propane, nitrogen and the like.

Furthermore, embodiments of the triamino-pyridine derivative and/or the labeled triamino-pyridine derivative can be made into suppositories by mixing with a variety of bases such as emulsifying bases or water-soluble bases. Embodiments of the triamino-pyridine derivative and/or the labeled triamino-pyridine derivative can be administered rectally via a suppository. The suppository can include vehicles such as cocoa butter, carbowaxes and polyethylene glycols, which melt at body temperature, yet are solidified at room temperature.

Unit dosage forms for oral or rectal administration, such as syrups, elixirs, and suspensions, may be provided wherein each dosage unit, for example, teaspoonful, tablespoonful, tablet or suppository, contains a predetermined amount of the composition containing one or more inhibiting agents. Similarly, unit dosage forms for injection or intravenous administration may comprise the triamino-pyridine derivative and/or the labeled triamino-pyridine derivative in a composition as a solution in sterile water, normal saline or another pharmaceutically acceptable carrier.

Embodiments of the triamino-pyridine derivative and/or the labeled triamino-pyridine derivative can be formulated in an injectable composition in accordance with the invention. Typically, injectable compositions are prepared as liquid solutions or suspensions; solid forms suitable for solution in, or suspension in, liquid vehicles prior to injection may also be prepared. The preparation may also be emulsified or the active ingredient (triamino-pyridine derivative and/or the labeled triamino-pyridine derivative) encapsulated in liposome vehicles in accordance with the present disclosure.

In an embodiment, the triamino-pyridine derivative and/or the labeled triamino-pyridine derivative is formulated for delivery by a continuous delivery system. The term “continuous delivery system” is used interchangeably herein with “controlled delivery system” and encompasses continuous (e.g., controlled) delivery devices (e.g., pumps) in combination with catheters, injection devices, and the like, a wide variety of which are known in the art.

Mechanical or electromechanical infusion pumps can also be suitable for use with the present disclosure. Examples of such devices include those described in, for example, U.S. Pat. Nos. 4,692,147; 4,360,019; 4,487,603; 4,360,019; 4,725,852; 5,820,589; 5,643,207; 6,198,966; and the like. In general, delivery of the triamino-pyridine derivative and/or the labeled triamino-pyridine derivative can be accomplished using any of a variety of refillable, pump systems. Pumps provide consistent, controlled release over time. In some embodiments, the triamino-pyridine derivative and/or the labeled triamino-pyridine derivative is in a liquid formulation in a drug-impermeable reservoir, and is delivered in a continuous fashion to the individual.

In one embodiment, the drug delivery system is an at least partially implantable device. The implantable device can be implanted at any suitable implantation site using methods and devices well known in the art. An implantation site is a site within the body of a subject at which a drug delivery device is introduced and positioned. Implantation sites include, but are not necessarily limited to, a subdermal, subcutaneous, intramuscular, or other suitable site within a subject's body. Subcutaneous implantation sites are used in some embodiments because of convenience in implantation and removal of the drug delivery device.

Drug release devices suitable for use in the disclosure may be based on any of a variety of modes of operation. For example, the drug release device can be based upon a diffusive system, a convective system, or an erodible system (e.g., an erosion-based system). For example, the drug release device can be an electrochemical pump, osmotic pump, an electroosmotic pump, a vapor pressure pump, or osmotic bursting matrix, e.g., where the drug is incorporated into a polymer and the polymer provides for release of drug formulation concomitant with degradation of a drug-impregnated polymeric material (e.g., a biodegradable, drug-impregnated polymeric material). In other embodiments, the drug release device is based upon an electrodiffusion system, an electrolytic pump, an effervescent pump, a piezoelectric pump, a hydrolytic system, etc.

Drug release devices based upon a mechanical or electromechanical infusion pump can also be suitable for use with the present disclosure. Examples of such devices include those described in, for example, U.S. Pat. Nos. 4,692,147; 4,360,019; 4,487,603; 4,360,019; 4,725,852, and the like. In general, a subject treatment method can be accomplished using any of a variety of refillable, non-exchangeable pump systems. Pumps and other convective systems are generally preferred due to their generally more consistent, controlled release over time. Osmotic pumps are used in some embodiments due to their combined advantages of more consistent controlled release and relatively small size (see, e.g., PCT published application no. WO 97/27840 and U.S. Pat. Nos. 5,985,305 and 5,728,396). Exemplary osmotically-driven devices suitable for use in the disclosure include, but are not necessarily limited to, those described in U.S. Pat. Nos. 3,760,984; 3,845,770; 3,916,899; 3,923,426; 3,987,790; 3,995,631; 3,916,899; 4,016,880; 4,036,228; 4,111,202; 4,111,203; 4,203,440; 4,203,442; 4,210,139; 4,327,725; 4,627,850; 4,865,845; 5,057,318; 5,059,423; 5,112,614; 5,137,727; 5,234,692; 5,234,693; 5,728,396; and the like.

In some embodiments, the drug delivery device is an implantable device. The drug delivery device can be implanted at any suitable implantation site using methods and devices well known in the art. As noted herein, an implantation site is a site within the body of a subject at which a drug delivery device is introduced and positioned. Implantation sites include, but are not necessarily limited to a subdermal, subcutaneous, intramuscular, or other suitable site within a subject's body.

In some embodiments, an active agent is delivered using an implantable drug delivery system, e.g., a system that is programmable to provide for administration of the agent. Exemplary programmable, implantable systems include implantable infusion pumps. Exemplary implantable infusion pumps, or devices useful in connection with such pumps, are described in, for example, U.S. Pat. Nos. 4,350,155; 5,443,450; 5,814,019; 5,976,109; 6,017,328; 6,171,276; 6,241,704; 6,464,687; 6,475,180; and 6,512,954. A further exemplary device that can be adapted for the present disclosure is the Synchromed infusion pump (Medtronic).

Suitable excipient vehicles for the inhibiting agent are, for example, water, saline, dextrose, glycerol, ethanol, or the like, and combinations thereof. In addition, if desired, the vehicle may contain minor amounts of auxiliary substances such as wetting or emulsifying agents or pH buffering agents. Methods of preparing such dosage forms are known, or will be apparent upon consideration of this disclosure, to those skilled in the art. See, e.g., Remington's Pharmaceutical Sciences, Mack Publishing Company, Easton, Pa., 17th edition, 1985. The composition or formulation to be administered will, in any event, contain a quantity of the triamino-pyridine derivative and/or the labeled triamino-pyridine derivative adequate to achieve the desired state in the subject being treated.

Compositions of the present disclosure include those that comprise a sustained-release or controlled release matrix. In addition, embodiments of the present disclosure can be used in conjunction with other treatments that use sustained-release formulations. As used herein, a sustained-release matrix is a matrix made of materials, usually polymers, which are degradable by enzymatic or acid-based hydrolysis or by dissolution. Once inserted into the body, the matrix is acted upon by enzymes and body fluids. A sustained-release matrix desirably is chosen from biocompatible materials such as liposomes, polylactides (polylactic acid), polyglycolide (polymer of glycolic acid), polylactide co-glycolide (copolymers of lactic acid and glycolic acid), polyan hydrides, poly(ortho)esters, polypeptides, hyaluronic acid, collagen, chondroitin sulfate, carboxcylic acids, fatty acids, phospholipids, polysaccharides, nucleic acids, polyamino acids, amino acids such as phenylalanine, tyrosine, isoleucine, polynucleotides, polyvinyl propylene, polyvinylpyrrolidone and silicone. Illustrative biodegradable matrices include a polylactide matrix, a polyglycolide matrix, and a polylactide co-glycolide (co-polymers of lactic acid and glycolic acid) matrix.

In another embodiment, the pharmaceutical composition of the present disclosure (as well as combination compositions) can be delivered in a controlled release system. For example, the triamino-pyridine derivative and/or the labeled triamino-pyridine derivative may be administered using intravenous infusion, an implantable osmotic pump, a transdermal patch, liposomes, or other modes of administration. In one embodiment, a pump may be used (Sefton (1987). CRC Crit. Ref Biomed. Eng. 14:201; Buchwald et al. (1980). Surgery 88:507; Saudek et al. (1989). N. Engl. J. Med. 321:574). In another embodiment, polymeric materials are used. In yet another embodiment a controlled release system is placed in proximity of the therapeutic target thus requiring only a fraction of the systemic dose. In yet another embodiment, a controlled release system is placed in proximity of the therapeutic target, thus requiring only a fraction of the systemic. Other controlled release systems are discussed in the review by Langer (1990). Science 249:1527-1533.

In another embodiment, the compositions of the present disclosure (as well as combination compositions separately or together) include those formed by impregnation of the triamino-pyridine derivative and/or the labeled triamino-pyridine derivative described herein into absorptive materials, such as sutures, bandages, and gauze, or coated onto the surface of solid phase materials, such as surgical staples, zippers and catheters to deliver the compositions. Other delivery systems of this type will be readily apparent to those skilled in the art in view of the instant disclosure.

Dosages

Embodiments of the triamino-pyridine derivative and/or the labeled triamino-pyridine derivative can be administered to a host in one or more doses. Those of skill will readily appreciate that dose levels can vary as a function of the specific triamino-pyridine derivative and/or the labeled triamino-pyridine derivative administered, the severity of the symptoms and the susceptibility of the subject to side effects. Preferred dosages for a given compound are readily determinable by those of skill in the art by a variety of means.

In an embodiment, multiple doses of the triamino-pyridine derivative and/or the labeled triamino-pyridine derivative are administered. The frequency of administration of the triamino-pyridine derivative and/or the labeled triamino-pyridine derivative can vary depending on any of a variety of factors, e.g., severity of the symptoms, and the like. For example, in an embodiment, the triamino-pyridine derivative and/or the labeled triamino-pyridine derivative is administered once per month, twice per month, three times per month, every other week (qow), once per week (qw), twice per week (biw), three times per week (tiw), four times per week, five times per week, six times per week, every other day (god), daily (qd), twice a day (qid), or three times a day (tid). As discussed above, in an embodiment, the triamino-pyridine derivative and/or the labeled triamino-pyridine derivative is administered continuously.

The duration of administration of the triamino-pyridine derivative and/or the labeled triamino-pyridine derivative, e.g., the period of time over which the triamino-pyridine derivative and/or the labeled triamino-pyridine derivative is administered, can vary, depending on any of a variety of factors, e.g., patient response, etc. For example, the triamino-pyridine derivative and/or the labeled triamino-pyridine derivative can be administered over a period of time of about one day to one week, about two weeks to four weeks, about one month to two months, about two months to four months, about four months to six months, about six months to eight months, about eight months to 1 year, about 1 year to 2 years, or about 2 years to 4 years, or more.

Routes of Administration

Embodiments of the present disclosure provide methods and compositions for the administration of the active agent (e.g., triamino-pyridine derivative and/or the labeled triamino-pyridine derivative) to a host (e.g., a human) using any available method and route suitable for drug delivery, including in vivo and ex vivo methods, as well as systemic and localized routes of administration.

Routes of administration include intranasal, intramuscular, intratracheal, subcutaneous, intradermal, topical application, intravenous, rectal, nasal, oral, and other enteral and parenteral routes of administration. Routes of administration may be combined, if desired, or adjusted depending upon the agent and/or the desired effect. An active agent (e.g., triamino-pyridine derivative and/or the labeled triamino-pyridine derivative) can be administered in a single dose or in multiple doses.

Embodiments of the triamino-pyridine derivative and/or the labeled triamino-pyridine derivative can be administered to a host using available conventional methods and routes suitable for delivery of conventional drugs, including systemic or localized routes. In general, routes of administration contemplated by the disclosure include, but are not limited to, enteral, parenteral, or inhalational routes.

Parenteral routes of administration other than inhalation administration include, but are not limited to, topical, transdermal, subcutaneous, intramuscular, intraorbital, intracapsular, intraspinal, intrasternal, and intravenous routes, i.e., any route of administration other than through the alimentary canal. Parenteral administration can be conducted to effect systemic or local delivery of the triamino-pyridine derivative and/or the labeled triamino-pyridine derivative. Where systemic delivery is desired, administration typically involves invasive or systemically absorbed topical or mucosal administration of pharmaceutical preparations.

The triamino-pyridine derivative and/or the labeled triamino-pyridine derivative can also be delivered to the subject by enteral administration. Enteral routes of administration include, but are not limited to, oral and rectal (e.g., using a suppository) delivery.

Methods of administration of the triamino-pyridine derivative and/or the labeled triamino-pyridine derivative through the skin or mucosa include, but are not limited to, topical application of a suitable pharmaceutical preparation, transdermal transmission, injection and epidermal administration. For transdermal transmission, absorption promoters or iontophoresis are suitable methods. Iontophoretic transmission may be accomplished using commercially available “patches” that deliver their product continuously via electric pulses through unbroken skin for periods of several days or more.

EXAMPLES

Example 1

Compounds disclosed herein can be represented by one of the following general structures VI-XV. The lists of substituents for the R1-R8 and X2 groups are shown in Tables 1-10 and are described above.

TABLE 1
embedded image VI

TABLE 2
embedded image VII

TABLE 3
embedded image VIII

TABLE 4
embedded image IXa

TABLE 4
embedded image IXb

TABLE 5
embedded image X

TABLE 6
embedded image XI

TABLE 7
embedded image XII

TABLE 8
embedded image XIII

TABLE 9
embedded image XIV

TABLE 10
embedded image XV

Example 2

Compounds of general structure VI are shown in Table 1 and may be synthesized by the sequence shown in Scheme 1. The R1—N—R2 groups contained in these structures can be purchased commercially or prepared according to known literature procedures. Chen, et al. J. Labelled. Cpd. Radiopharm. (1999) 42:Suppl. 1:S400; Hsin, et al. Bioorg. Med. Chem. Lett. (2000) 10:707; Hsin, J. Labelled Cpd. Radiopharm. (2000) 43:899; Martarello, et al. Nuc. Med. Biol. (2001) 28:187; Dubowchik, et al. Bioorg. Med. Chem. Lett. (2004) 14:3147; Singh, et al. Eur. J. Org. Chem. (2007) 8:1369.

Compounds which contain a bulky ortho-substituent will have reduced rotation around the bond connecting the aniline ring to the central core and will experience atropisomerism. Eliel, et al. Stereochemistry of Organic Compounds. (1994) John Wiley & Sons, Inc.: NY.

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Atropisomerism can be observed by 1H NMR (FIG. 1) due to diastereotopic splitting of the protons on the α-carbon of the acetamide group. Nelson, J. Nuclear Magnetic Resonance Spectroscopy (2003) Pearson Education, Inc.: Upper Saddle River, N.J. Atropisomeric compounds can be separated by chiral HPLC or chiral crystallization. Shi, et al. J. Chromatogr. A (2005) 1078:67; Anand, et al. Tetrahedron (2007) 63:5236; Erol, et al. J. Org. Chem. (2007) 72:2494; Vrudhula, J. Med. Chem. (2007) 50:1050.

Example 3

Compounds of general structure VII (Table 2) and VIII (Table 3) may be prepared as shown in Schemes 2 and 3, respectively.

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Example 4

Compounds of general structure XVI and XVII (derived from VI) which contain a halogen (Br, I) or other group suitable for coupling in the ortho- or para-positions (X1) can be coupled to (Z)-1,2-bis(trimethylstannyl)ethene or tributyl(vinyl)tin (for X2=H compounds) to give the vinyl compounds (X2=H, SnMe3) and will provide both the cis and trans isomers when X2=SnMe3 (Schemes 2 and 3). Mitchell, et al. J. Organomet. Chem. (1986) 304:257; Blough, et al. J. Med. Chem. (2002) 45:4029; Stehouwer, et al. J. Med. Chem. (2006) 49:6760. The vinyltin compounds (X2=SnMe3) can then be converted to the corresponding vinylhalide compounds (X2=Br, I) by halo-destannylation. Stehouwer, at al. J. Med. Chem. (2006) 49:6760. This halo-destannylation reaction can also be used for radiolabeling. (Scheme 15). Goodman, et al. J. Med. Chem. (2003) 46:925; Plisson, et al. J. Med. Chem. (2004) 47:1122.

Example 5

The aniline ring of XVI can be linked to the central core to give compounds of general structure IX (Table 4) as shown in Scheme 4. Coupling of XVI with (Z)-3-(tri-n-butylstannyl)-2-propen-1-ol, (Z)-4-(tri-n-butylstannyl)-3-buten-1-ol, or (7)-5-(tri-n-butylstannyl)-4-penten-1-ol, provides the intermediate alcohol XVIII which can then be converted to the tosylate (or other appropriate leaving group) XIX. Leusink, et al. J. Organometal. Chem. (1967) 9:285; Jung, et al. Tetrahedron Lett. (1982) 23:3851; Miura, et al. J. Org. Chem. (2003) 68:8730; Dussault, J. Am. Chem. Soc. (1998) 120:7133. Treatment of XIX with a strong base such as a metal hydride or metal amide will generate an enolate which will then displace the leaving group and provide compounds IX. Alternatively, XVI can be treated first with a strong base such as a metal hydride or metal amide to provide an enolate which can then be alkylated with a vinyltin-alkane containing a leaving group (halogen, alkyl sulfonate, etc.) to give XX. Subjection of XX to metal-catalyzed coupling conditions will then provide compounds IX.

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Example 6

Compounds of general structure X (Table 5) can be synthesized as shown in Scheme 5. Reaction of compound IV with a haloacetyl halide (chloroacetyl chloride, bromoacetyl bromide, bromoacetyl chloride, etc.) or a haloacetic anhydride (chloroacetic anhydride, bromoacetic anhydride, iodoacetic anhydride) will afford compound XXI which can then be cyclized under conditions similar to that employed to prepare VI from V (Scheme 1) to afford compounds X. Placing the carbonyl group in this position creates additional steric hindrance between the aniline ring and central core and will, therefore, produce atropisomers as mentioned above.

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Example 7

Compounds of general structure XI (Table 6) and XII (Table 7) are prepared from compounds XXII and XXIII, respectively, by the same method with which compounds VII and VIII are prepared from XVI and XVII, respectively (Schemes 2 and 3).

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Example 8

Compounds of general structure XIII (Table 8) are prepared as shown in Scheme 6. Reduction of III affords XXIV which can be reacted with a haloacetyl halide (chloroacetyl chloride, bromoacetyl bromide, bromoacetyl chloride, etc.) or a haloacetic anhydride (chloroacetic anhydride, bromoacetic anhydride, iodoacetic anhydride) to give compound XXV as well as compounds XXVI and XXVII (see below). Reaction of XXV with a benzyl amine derivative affords XXVIII (and also XXVI and XXVII as side products) which can be cyclized by heating in a high-boiling alcohol (including, but not limited to, n-butanol, isoamyl alcohol, cyclohexanol) in the presence of base to afford XIII. As a specific example of XIII, FIG. 2 shows the X-ray crystal structure of compound 8374.HCl (Table 8, R1=Bu, R2=Et, R6=H, R7=H).

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Example 9

Scheme 7 demonstrates a specific example of the synthesis of compounds of type XXVI and XXVII. Reaction of XXIX with chloroacetic anhydride and diisopropylethylamine (i-Pr2Net) in CHCl3 affords compound XXX in which the nitrogen lone pair can attack the chloro-acetamide group to give the proposed transient compound XXXI. A chloride anion can then attack either the butyl or ethyl group of XXXI to give compounds XXXIII and XXXII, respectively. The X-ray crystal structures of XXXII and XXXIII are shown in FIGS. 3 and 4, respectively. Compounds XXXII and XXXIII can also be prepared directly by heating XXX in an appropriate solvent in the presence of base.

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Example 10

Compounds of general structures XIV (Table 9) and XV (Table 10) can be prepared from compounds of type XXVI and XXVII as shown in Scheme 8. Reaction of XXVI/XXVII with aniline derivatives by known literature methods will provide compound XXXIV which can be reacted with a dihaloalkane (CH2X2, XCH2CH2X, etc.) or other alkane with suitable leaving groups (e.g. alkylsulfonate esters) to afford compound XIV. Guo, et al. J. Med. Chem. (2005) 48:5104; Gentile, et al. Bioorg. Med. Chem. Lett. (2007) 17:5218.

Example 11

Compound XXXIV can also be reacted with phosgene, triphosgene, diethylcarbonate, etc. to afford compound XV. Compounds XIV and XV can be N-dealkylated (R8) to afford compound XXXV. Guo, et al. J. Med. Chem. (2005) 48:5104; Beck, et al. Bioorg. Med. Chem. Lett. (1999) 9:967; He, et al. J. Med. Chem. (2000) 43:449. Alternatively, if R8=Bn (obtained by reacting I with N-benzylmethylamine and then carrying the product through the synthetic sequences shown above) the N-benzyl group can be removed by hydrogenolysis on Pd/C to afford XXXV. Compound XXXV can then be N-alkylated to afford additional derivatives or radiolabeled compounds (see below). Guo, et al. J. Med. Chem. (2005) 48:5104; Gross, et al. J. Med. Chem. (2005) 48:5780.

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Example 12

The radiosynthetic methods for preparing these radiolabeled derivatives are summarized below. Many of the radiosyntheses can be accomplished by nucleophilic SN2 reactions such as O- and N-alkylations (Schemes 9 and 10) which are common radiolabeling methods reported in the literature. Kumar, et al. Bioorg. Med. Chem. (2006) 14:4029; Sullivan, Nuc. Med. Biol. (2007) 34:353; Scott, et al. J. Label. Compd. Radiopharm. (2007) 50:Supplement 1:S124; Stehouwer, et al. J. Med. Chem. (2005) 48:7080. Reaction with [11C]methyl iodide or [11C]methyl triflate allows for the introduction of a [11C]-radiolabel while reaction with a [18F]fluoroalkane containing a leaving group (e.g. [18F]fluoromethyl tosylate, [18F]fluoroethyl tosylate, [18F]fluoroethyl brosylate, [18F]fluoropropyl brosylate, (E/Z)-[18F]-1-fluoro-4-tosyl-2-butene, etc.) allows for the introduction of an [18F]-radiolabel. [18F]Fluoromethyl derivatives can be prepared from ditosylmethane derivatives as shown in Scheme 11. Reaction of diiodomethane, diiodomethane-D2, or dibromodifluoromethane with silver tosylate will afford ditosylates XXXVI which can then be reacted with 18F to give the [18F]-alkylating agents XXXVII. Emmons, et al. J. Am. Chem. Soc. (1953) 75:2257; Neal, et al. J. Label. Compd. Radiopharm. (2003) 46:Supplement 1:S198. Alternatively, 16FCH2Br can be prepared from dibromomethane and 18FCBrF2 can be prepared from dibromodifluoromethane. Eskola, et al. J. Label. Compd. Radiopharm. (1999) 42:Supplement 1:S543; Viljanen, J. Label. Compd. Radiopharm. 2003, 46, Supplement 1, S219. Compounds XXXVII can then be used as shown in Schemes 9 and 10. Compounds containing the —OCF218F group can also be prepared from chlorodifluoromethoxy precursors. Hagooly, et al. Eur. J. Org. Chem. (2008) 17:2875.

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Example 13

Employing 18F as a nucleophile is another common literature method for radiolabeling. As shown in Scheme 12, displacing a leaving group (halogen, alkyl sulfonate, etc.) from an alkyl group allows for the creation of an [18F]alkyl substituent. Kim, et al. J. Am. Chem. Soc. (2006) 128:16394; Hsin, et al. Bioorg. Med. Chem. Lett. (2000) 10:707; Hsin, et al. J. Labelled Cpd. Radiopharm. (2000) 43:899; Martarello, et al. Nuc. Med. Biol. (2001) 28:187. [18F]Fluorination of an aromatic ring can be achieved by displacing a halide, nitro group, trialkylammonium halide or triflate, or an iodonium salt, as shown in Scheme 13. Oya, et al. J. Med. Chem. (2002) 45:4716; Mach, et al. Nucl. Med. Biol. (1993) 20:777; Kuhnast, et al. J. Label. Compd. Radiopharm. (2008) 51:336; Koser, et al. J. Org. Chem. (1980) 45:1542; Koser, et al. J. Org. Chem. (1980) 45:1543; Pike, et al. J. Chem. Soc., Perkin Trans. 1 (1999) 245; Ross, et al. J. Am. Chem. Soc. (2007) 129:8018.

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Example 14

Coupling reactions with [11C]methyl iodide or [11C]methyl triflate can be employed to connect a [11C]radiolabel to an aromatic ring as shown in Scheme 14. Suzuki, et al. Chem. Eur. J. (1997) 3:2039; Björkman, J. Label. Compd. Radiopharm. (2000) 43:1327; Karimi, et al. J. Label. Compd. Radiopharm. (2002) 45:423. Halodestannylation reactions with a vinyl stannane are a method of preparing radiolabeled vinyl halides and an example is shown in Scheme 15. Tamagnan, NeuroImage (2006) 31:T131; Plisson, J. Med. Chem. (2004) 47:1122; Goodman, J. Med. Chem. (2003) 46:925.

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Thus, Schemes 9-15 demonstrate generation of the radiolabeled versions of the compounds listed in Tables 1-10 (excluding the radiolabeling precursors that are listed in those tables) using known literature procedures. Disclosed herein are the radiolabeling precursors (those listed in as well as those not listed in Tables 1-10) that are necessary to prepare these radiolabeled compounds (e.g. R1 or R2=alkyl containing a leaving group) as well as the intermediates that are necessary to prepare these radiolabeling precursors (e.g., R1 or R2=alkyl containing a hydroxyl group for conversion to a leaving group).

Example 15

“Click-chemistry” is the Cu(I)-catalyzed 1,3-dipolar cycloaddition of a terminal alkyne and an azide (Scheme 16) and this method has been used successfully for radio-labeling PET tracers (Schemes 17 and 18). Kolb, et al. Angew. Chem. Int. Ed. (2001) 40:2004; Rostovtsev, et al. Angew. Chem. Int. Ed. (2002) 41:2596; Kolb, et al. Drug Discovery Today (2003) 8:1128; Wang, et al. Green Chem. (2008) 10:452; Marik, et al. Tetrahedron Lett. (2006) 47:6681; Glaser, et al. Bioconjugate Chem. (2007) 18:989; Kuhnast, et al. J. Label. Compd. Radiopharm. (2008) 51:336; Smith, et al. J. Med. Chem. (2008) 51:8057.

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Accordingly, the compounds with general structure XXXVIII (Scheme 19) can be reacted under click chemistry conditions to give compounds of general structures XXXIX and XXXX, where R12=H, OH, O-alkyl, alkyl, halogen, haloalkyl, heteroalkyl; R13=H, alkyl, haloalkyl, heteroalkyl; and where R1 and R2 are as defined in Tables 1-8; and the derivatives of compounds VI-XIII where R1=propargyl derivatives (example: compound XXXXI, Scheme 20) and where R2-R7, X2, n=as defined in Tables 1-8; and also the derivatives of compounds XIV and XV where R8=propargyl derivatives, and R3 and n are as defined in Tables 9 and 10. Furthermore, triazole products that can result from performing click-chemistry on these compounds (e.g., compounds XXXXII and XXXXIII).

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Example 16

Specific Examples

Pyrido[2,3-b]pyrazin-2-ones of type VI (Table 1) were synthesized according to the procedure reported by Dzierba, et al. (J. Med. Chem. 2004, 47, 5783-5790) as shown in Scheme 21. 4-(N-Butyl-N-ethylamino)-2-chloro-6-methyl-3-nitro-pyridine (J. Med. Chem. 2004, 47, 5783-5790) was reacted neat with an aniline derivative to give the aniline-substituted nitro-pyridines 17217, 17218, and 17219. These were deprotonated with NaH and reacted with ethyl iodoacetate to give compounds 17220, 17221, and 17222 which were reductively cyclized to afford the target compounds 185, 188, and 191. Compounds 185, 188, and 191 were screened for binding affinity vs. [125I]sauvagine (Mol. Pharmacol. 1996, 50, 679-686) at the CRF-1 receptor using transfected HEK293T/17 cells expressing the CRF-1 receptor according to standard in vitro competitive binding procedures. (Mol. Pharmacol. 2003, 63, 751-765; Peptides 2003, 24, 1881-1897; Peptides 2005, 26, 457-470) The binding affinities of compounds 185, 188, and 191 are shown in Table 11 along with the binding affinities of sauvagine and R121919, (Neuropsychopharmacology 2002, 27, 194-202; J. Med. Chem. 2004, 47, 4787-4798) for comparison. Compounds 185, 188, and 191 all have a high affinity for the CRF-1 receptor, only slightly reduced from that found for R121919, indicating that these compounds are potential antagonists of the CRF-1 receptor and also may potentially be employed as imaging agents.

Scheme 22 shows the conversion of bromo-compound 185 to the trimethylstannyl-compound 190, which was accomplished by reacting 185 with hexamethylditin in the presence of catalytic Pd. Compound 190 can serve as the radiolabeling precursor to prepare [11C]191 (Scheme 14). The bulkiness of the trimethylstannyl group of 190 restricts the rotation of the aniline ring resulting in atropisornerism as demonstrated by the diastereotopic proton splitting pattern in the 1H NMR spectrum (FIG. 1).

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TABLE 11
CRF-1 Receptor Binding Affinities (vs. [125I] Sauvagine).
Ki (nM)
SauvagineR121919185188191
0.45 ± 0.054.1 ± 0.46.2 ± 1.45.7 ± 0.39.1
(n = 5)(n = 10)(n = 2)(n = 2)(n = 1)

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FIG. 1 illustrates the 1H NMR spectra (600 MHz, CDCl3) of compounds 191, 185, and 190 demonstrating the existence of atropisomerism due to restricted rotation of the aniline ring.

Compounds of type XIII (Table 8) were synthesized as shown in Scheme 23. 4-(N-Butyl-N-ethylamino)-2-chloro-6-methyl-3-nitro-pyridine (J. Med. Chem. 2004, 47, 5783-5790) was reduced with SnCl2 to give the substituted aminopyridine XXIX. Reaction of XXIX with chloroacetic anhydride afforded chloroacetamido-pyridine XXX along with compounds XXXII and XXXIII as side-products (see Scheme 7). Chloroacetamido-pyridine XXX was then reacted with benzylamine or a benzylamine derivative to give compounds 17223-17227 (along with compounds XXXII and XXXIII as side-products). Compounds 17223-17225 were then cyclized to compounds 8374-8376, respectively, by stirring in refluxing nBuOH in the presence of base, whereas compounds 17226 and 17227 were cyclized to compounds 8404 and 8409, respectively, by stirring in refluxing cyclohexanol in the presence of base. Compound 8374 was converted to the HCl salt by adding HCl/EtOEt to a solution of 8374 in EtOEt. The X-ray crystal structure of 8374.HCl is shown in FIG. 2.

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FIG. 2 illustrates the thermal ellipsoid representation of the X-ray crystal structure of 8374.HCl.

TABLE 12
Crystal data and structure refinement for 8374•HCl.
Empirical formulaC21H29ClN4O
Formula weight 388.93
Temperature173(2) K
Wavelength1.54178 Å
Crystal systemMonoclinic
Space groupP2(1)/c
Unit cell dimensionsa = 11.5688(9) Åα = 90°.
b = 12.7793(11) Åβ = 93.995(4)°.
c = 14.2458(9) Åγ = 90°.
Volume2101.0(3) Å3
Z  4
Density (calculated)1.230 Mg/m3
Absorption coefficient1.741 mm−1
F(000) 832
Crystal size0.24 × 0.19 × 0.07 mm3
Theta range for data collection3.83 to 65.21°.
Index ranges−12 <= h <= 13, −13 <= k <= 14,
−16 <= l <= 16
Reflections collected9738
Independent reflections3234 [R(int) = 0.0578]
Completeness to theta = 65.21°89.8%
Absorption correctionSemi-empirical from equivalents
Max. and min. transmission0.8879 and 0.6801
Refinement methodFull-matrix least-squares on F2
Data/restraints/parameters3234/0/256
Goodness-of-fit on F2  1.035
Final R indices [I > 2sigma(I)]R1 = 0.0444, wR2 = 0.1113
R indices (all data)R1 = 0.0728, wR2 = 0.1331
Extinction coefficient0.0008(2)
Largest diff. peak and hole0.310 and −0.260 e.Å−3

Compounds XXXII and XXXIII can also be prepared by reacting compound XXIX with bromoacetic anhydride. The X-ray crystal structures of XXXII and XXXIII are shown in FIGS. 3 and 4, respectively, and the crystal data is shown in Tables 13 and 14, respectively.

FIG. 3 illustrates the thermal ellipsoid representation of the X-ray crystal structure of XXXII.

TABLE 13
Crystal data and structure refinement for XXXII.
Empirical formulaC12 H14.35 Cl N3 O1.35
Formula weight 257.66
Temperature173(2) K
Wavelength1.54178 Å
Crystal systemTriclinic
Space groupP-1
Unit cell dimensionsa = 7.2453(17) Åα = 69.509(14)°.
b = 9.187(2) Åβ = 86.852(12)°.
c = 9.997(2) Åγ = 80.726(14)°.
Volume615.2(3) Å3
Z  2
Density (calculated)1.391 Mg/m3
Absorption coefficient2.685 mm−1
F(000) 270
Crystal size0.33 × 0.31 × 0.30 mm3
Theta range for data collection4.72 to 65.80°.
Index ranges−8 <= h <= 8, −9 <= k <= 10,
−11 <= l <= 11
Reflections collected4412
Independent reflections1700 [R(int) = 0.0383]
Completeness to theta = 65.80°79.7%
Absorption correctionSemi-empirical from equivalents
Max. and min. transmission0.4997 and 0.4711
Refinement methodFull-matrix least-squares on F2
Data/restraints/parameters1700/0/166
Goodness-of-fit on F2  1.235
Final R indices [I > 2sigma(I)]R1 = 0.0751, wR2 = 0.2179
R indices (all data)R1 = 0.0949, wR2 = 0.2683
Extinction coefficient0.011(4)
Largest diff. peak and hole0.608 and −0.566 e.Å−3

FIG. 4 illustrates the thermal ellipsoid representation of the X-ray crystal structure of XXXIII.

TABLE 14
Crystal data and structure refinement for XXXIII.
Empirical formulaC10 H12 Cl N3 O
Formula weight 225.68
Temperature173(2) K
Wavelength1.54178 Å
Crystal systemMonoclinic
Space groupP2(1)/n
Unit cell dimensionsa = 6.9906(5) Åα = 90°.
b = 9.0272(7) Åβ = 101.034(4)°.
c = 16.7567(11)Åγ = 90°.
Volume1037.89(13) Å3
Z  4
Density (calculated)1.444 Mg/m3
Absorption coefficient3.072 mm−1
F(000) 472
Crystal size0.39 × 0.28 × 0.04 mm3
Theta range for data collection5.38 to 65.54°.
Index ranges−6 <= h <= 7, −9 <= k <= 9, −17 <= l <= 19
Reflections collected4339
Independent reflections1476 [R(int) = 0.0235]
Completeness to theta = 65.54°82.2%
Absorption correctionSemi-empirical from equivalents
Max. and min. transmission0.9001 and 0.3805
Refinement methodFull-matrix least-squares on F2
Data/restraints/parameters1476/0/142
Goodness-of-fit on F2  1.047
Final R indices [I > 2sigma(I)]R1 = 0.0327, wR2 = 0.0887
R indices (all data)R1 = 0.0337, wR2 = 0.0899
Largest diff. peak and hole0.206 and −0.217 e.Å−3

Experimental

General.

NMR spectra were obtained on Varian Unity and Inova spectrometers at the specified frequencies. 1H chemical shifts are referenced to internal TMS or residual CHCl3 (7.26 ppm) and 13C chemical shifts are referenced to CDCl3 (77.23 ppm). Solvents were purchased from VWR and had originated from EMD or Burdick & Jackson. Anhydrous solvents (100-mL septum-capped bottles) were purchased from Aldrich. TLC plates used were EMD glass-backed Silica Gel 60 F254, 20×20 cm, 250 μm. Preparatory TLC plates used were Analtech Uniplate Silica Gel GF 20×20 cm, 2000 μm. Silica gel used was EMD Silica Gel 60, 40-63 μm. Radial chromatography was performed with a Harrison Research Chromatotron. Semi-preparatory HPLC: Waters XTerra Prep RP13, 5 μm, 19×100 mm+guard cartridge (19×10 mm). Analytical HPLC: Waters NovaPak 3.9×150 mm. HRMS was performed by the Emory University Mass Spectrometry Center. X-ray diffraction data collection and structure determination was performed by the Emory University X-ray Crystallography Center.

4-(2-Bromo-4-methylphenyl)-8-(butylethylamino)-6-methyl-3,4-dihydro-1H-pyrido[2,3-b]pyrazin-2-one (185)

{(2-Bromo-4-methylphenyl)-[4-(butylethylamino)-6-methyl-3-nitropyridin-2-yl]amino}acetic acid ethyl ester (0.33 g, 6.50×10−4 mol), Fe° (0.36 g, 6.45 mmol, 9.9 equiv.), conc. HCl(aq) (0.85 mL, 10.2 mmol, 15.7 equiv.), EtOH (15 mL), and boiling chips were heated at reflux under Ar(g) for 16 h. The reaction mixture was cooled to rt, filtered through Celite, the Celite was rinsed with EtOH, and the solvent was removed from the filtrate to give a brown residue. To the residue was added CH2Cl2 (50 mL) and a suspension of EDTA.2Na+.2H2O (2.96 g, 7.95 mmol, 1.2 equiv. Fe0) in H2O (50 mL). The mixture was stirred at rt for 35 min, cooled to 0° C., and neutralized with conc. NH4OH(aq). The layers were separated, the aqueous layer was extracted with CH2Cl2 (20 mL×2), and the combined CH2Cl2 layers were dried over MgSO4. The solvent was removed to give a yellow-brown oil that was vacuum flash chromatographed on silica (40 mm h×43 mm i.d.): CH2Cl2 (50 mL), hexanes (50 mL), hexanes/EtOAc/NEt3 v/v/v 90:8:2 (100 mL), 75:20:5 (150 mL) to afford a colorless syrup that was further purified by radial chromatography (2 mm silica): hexanes/EtOAc/NEt3 v/v/v 95:4:1 (200 mL), 90:8:2 (50 mL), 75:20:5 (100 mL) to give 0.23 g (82%) of a sticky, white foam: TLC Rf=0.36 (silica, 75:20:5 v/v/v hexanes/EtOAc/NEt3); 1H NMR (600 MHz, CDCl3) δ 7.92 (br s, 1H), 7.48 (s, 1H), 7.24 (d, 1H, J=8.4 Hz), 7.18 (d, 1H, J=8.4 Hz), 6.35 (s, 1H), 4.38 and 4.32 (2 overlapping br s, 2H), 2.98 (q, 2H, J=7.2 Hz), 2.91 (t, 2H, J=7.2 Hz), 2.37 (s, 3H), 2.20 (s, 3H), 1.40 (m, 2H), 1.29 (sextet, 2H, J=7.2 Hz), 1.02 (t, 3H, J=7.2 Hz), 0.90 (t, 3H, J=7.2 Hz).

8-(Butylethylamino)-4-(2-methyl-4-bromophenyl)-6-methyl-3,4-dihydro-1H-pyrido[2,3-b]pyrazin-2-one (188)

{(2-Methyl-4-bromophenyl)-[4-(butylethylamino)-6-methyl-3-nitropyridin-2-yl]amino}acetic acid ethyl ester (0.24 g, 4.73×10−4 mol), Fe0 (0.37 g, 6.63 mmol, 14.0 equiv.), conc. HCl(aq) (0.60 mL, 7.2 mmol, 15.2 equiv.), EtOH (15 mL), and boiling chips were heated at reflux under Ar(g) for 16 h. The reaction mixture was cooled to rt, filtered through Celite, the Celite was rinsed with EtOH, and the solvent was removed from the filtrate to give a brown residue. To the residue was added CH2Cl2 (40 mL) and a suspension of EDTA.2Na+.2H2O (2.71 g, 7.28 mmol, 1.1 equiv. Fe0) in H2O (40 mL). The mixture was stirred at rt for 35 min, cooled to 0° C., and neutralized with conc. NH4OH(aq). The layers were separated, the aqueous layer was extracted with CH2Cl2 (20 mL×2), and the combined CH2Cl2 layers were dried over MgSO4. The solvent was removed to give a colorless syrup that was vacuum flash chromatographed on silica (40 mm h×43 mm i.d.): CH2Cl2 (50 mL), hexanes (50 mL), hexanes/EtOAc/NEt3 v/v/v 95:4:1 (100 mL) 90:8:2 (100 mL), 75:20:5 (150 mL) to afford a colorless syrup that was further purified by radial chromatography (2 mm silica): hexanes/EtOAc/NEt3 v/v/v 95:4:1 (300 mL), 90:8:2 (100 mL) to give 0.16 g (78%) of a white foam: TLC Rf=0.31 (silica, 75:20:5 v/v/v hexanes/EtOAc/NEt3); 1H NMR (600 MHz, CDCl3) δ 7.89 (br s, 1H), 7.41 (s, 1H), 7.38 (d, 1H, J=8.4 Hz), 7.09 (d, 1H, J=8.4 Hz), 6.36 (s, 1H), 4.30 (br s, 2H), 2.99 (q, 2H, J=7.2 Hz), 2.92 (t, 2H, J=7.2 Hz), 2.21 (s, 3H), 2.07 (s, 3H), 1.40 (m, 2H), 1.30 (sextet, 2H, J=7.2 Hz), 1.02 (t, 3H, J=7.2 Hz), 0.90 (t, 3H, J=7.2 Hz).

8-(Butylethylamino)-6-methyl-4-(2-trimethylstannyl-4-methylphenyl)-3,4-dihydro-1H-pyrido[2,3-b]pyrazin-2-one (190)

4-(2-Bromo-4-methylphenyl)-8-(butylethylamino)-6-methyl-3,4-dihydro-1H-pyrido[2,3-b]pyrazin-2-one (0.17 g, 3.94×10−4 mol), hexamethylditin (0.50 g, 1.53 mmol, 3.9 equiv.), Pd(PPh3)4 (48 mg, 4.15×10−5 mol, 0.1 equiv), and anhydrous toluene (25 mL) were stirred at reflux under Ar(g) for 16 h. The reaction mixture was cooled to rt, poured onto dry silica (40 mm h×43 mm i.d.), and eluted under vacuum: CH2Cl2 (50 mL), hexanes (50 mL), hexanes/EtOAc/NEt3 v/v/v 95:4:1 (100 mL), 90:8:2 (100 mL), 75:20:5 (150 mL) to give an off-white foam (0.16 g). Purification by preparatory-TLC (20×20 cm, 2 mm thickness, 90:8:2 v/v/v hexanes/EtOAc/NEt3×3) afforded recovered starting material (53 mg, 31%) and the trimethylstannyl target compound (86 mg) which was further purified by radial chromatography (1 mm silica): hexanes/EtOAc/NEt3 v/v/v 98:1:1 (180 mL), 95:4:1 (100 mL) to afford a pure fraction (22 mg) and an impure fraction that was further purified by preparatory-TLC (20×20 cm, 2 mm thickness, 90:8:2 v/v/v hexanes/EtOAc/NEt3×2). Total yield—61 mg (30%) as a white solid: TLC Rf=0.38 (silica, 75:20:5 v/v/v hexanes/EtOAc/NEt3); 1H NMR (600 MHz, CDCl3) δ 7.99 (br s, 1H), 7.35 (partially resolved td, 1H, JSnH=24.5 Hz), 7.25 (partially resolved d, 1H, J=1.8 Hz), 7.18 (dt, 1H, J=8.4 Hz, JSnH=12.6 Hz), 6.36 (s, 1H), 4.47 (d, 1H, J=16.2 Hz), 4.07 (d, 1H, J=16.2 Hz), 2.96 and 2.95 (2 overlapping q, 2H, J=7.2 Hz), 2.91 and 2.88 (2 overlapping t, 2H, J=7.2 Hz), 2.39 (s, 3H), 2.18 (s, 3H), 1.36 (m, 2H), 1.28 (sextet, 2H, J=7.2 Hz), 1.00 (t, 3H, J=7.2 Hz), 0.88 (t, 3H, J=7.2 Hz), 0.02 (t, 9H, J=27.0 Hz).

8-(Butylethylamino)-4-(2,4-dimethylphenyl)-6-methyl-3,4-dihydro-1H-pyrido[2,3-b]pyrazin-2-one (191)

{(2,4-Dimethylphenyl)-[4-(butylethylamino)-6-methyl-3-nitropyridin-2-yl]amino}acetic acid ethyl ester (63 mg, 1.42×10−4 mol), Fe0 (82 mg, 1.47 mmol, 10.4 equiv.), conc. HCl(aq) (0.20 mL, 2.4 mmol, 16.9 equiv.), EtOH (4 mL) and boiling chips were heated at reflux under Ar(g) for 15 h. The reaction mixture was cooled to rt, filtered through Celite, the Celite was rinsed with EtOH, and the solvent was removed from the filtrate to give a brown oil. To the residue was added CH2Cl2 (10 mL) and a suspension of EDTA.2Na+.2H2O (0.66 g, 1.77 mmol, 1.2 equiv.) Fe0) in H2O (10 mL). The mixture was stirred at rt for 30 min, cooled to 0° C., and neutralized with conc. NH4OH(aq). The layers were separated, the aqueous layer was extracted with CH2Cl2 (5 mL×2), and the combined CH2Cl2 layers were dried over MgSO4. The solvent was removed to give a blue-green syrup that was purified on silica Sep-Pak Classics (3 in series): CH2Cl2 (4 mL), hexanes (3 mL), hexanes/EtOAc/NEt3 v/v/v 95:4:1 (2 mL×2), 90:8:2 (1 mL×12), 85:12:3 (1 mL×8). The desired fractions were combined and purified again on silica Sep-Pak Classics (3 in series): CH2Cl2 (2 mL), hexanes/EtOAc/NEt3 v/v/v 95:4:1 (1 mL×25), 90:8:2 (5 mL×2) to afford 31 mg (59%) of a colorless syrup that solidified after scrapping and drying under vacuum: TLC Rf=0.34 (silica, 75:20:5 v/v/v hexanes/EtOAc/NEt3); 1H NMR (600 MHz, CDCl3) δ 7.93 (br s, 1H), 7.09 (m, 3H), 6.32 (s, 1H), 2.11 (2 overlapping br s, 2H), 2.99 (q, 2H, J=7.2 Hz), 2.91 (t, 2H, J=7.2 Hz), 2.35 (s, 3H), 2.20 (s, 3H), 2.08 (s, 3H), 1.40 (m, 2H), 1.30 (sextet, 2H, J=7.2 Hz), 1.02 (t, 3H, J=7.2 Hz), 0.90 (t, 3H, J=7.2 Hz).

3-Amino-4-(N-butyl-N-ethylamino)-2-chloro-6-methyl-pyridine (XXIX)

4-(N-Butyl-N-ethylamino)-2-chloro-6-methyl-3-nitro-pyridine (2.26 g, 8.32 mmol) was dissolved in MeOH (150 mL) followed by addition of 5 nCl2.2H2O (11.63 g, 51.55 mmol, 6.2 equiv.) and then conc. HCl(aq) (11 mL, 0.13 mol, 15.6 equiv.). The reaction mixture was stirred at reflux under Ar(g) for 17 h, cooled, and the solvent was removed to give a faint yellow oil that was dissolved in CH2Cl2 (125 mL) and added to a suspension of EDTA.2Na+.2H2O (23.87 g, 64.13 mmol, 1.2 equiv. Sn) in H2O (125 mL). The mixture was stirred at rt for 5 min (white precipitate formed) and then cooled to 0° C. (aqueous layer pH=0). The aqueous layer was neutralized to pH=6-7 with conc. NH4OH(aq), the mixture was filtered through Celite, and the layers were separated. The aqueous layer was extracted with CH2Cl2 (25 mL×3), the combined CH2Cl2 layers were dried over MgSO4, and the solvent was removed to give a yellow oil (1.97 g) that was purified by flash column chromatography (45 g silica, 1% MeOH/CH2Cl2-700 mL) to afford a colorless oil (1.34 g, 67%): TLC Rf=0.6 (silica, 5% MeOH/CH2Cl2); 1H NMR (600 MHz, CDCl3) δ 6.66 (br s, 1H), 4.00 (br s, 2H), 3.04 (q, 2H, J=7.2 Hz), 2.97 (t, 2H, J=7.5 Hz), 2.39 (s, 3H), 1.40 (quintet, 2H, J=7.5 Hz), 1.28 (sextet, 2H, J=7.5 Hz), 1.01 (t, 3H, J=7.2 Hz), 0.89 t, 3H, J=7.5 Hz); 13C NMR (150 MHz, CDCl3) δ 147.14, 146.49, 136.44, 133.14, 115.50, 50.53, 45.70, 29.29, 23.64, 20.46, 14.07, 12.26; HRMS (ESI) [MH]+ Calcd for C12H21N335Cl: 242.1419. found: 242.1415.

4-(N-Butyl-N-ethylamino)-3-(2-chloroacetamido)-2-chloro-6-methyl-pyridine (XXX)

3-Amino-4-(N-butyl-N-ethylamino)-2-chloro-6-methyl-pyridine (XXIX) (0.46 g, 1.90 mmol), chloroacetic anhydride (1.80 g, 10.53 mmol, 5.5 equiv.), iPr2NEt (0.51 mL, 2.9 mmol, 1.5 equiv.), and CHCl3 (50 mL) were stirred at reflux under Ar(g) for 17 h. The solvent was removed to give a yellow-brown oil that was dried under vacuum (2.67 g) and then purified by vacuum flash chromatography on silica (12.5 cm h×4 cm i.d.): CH2Cl2 (100 mL), hexanes (50 mL), hexanes/EtOAc/NEt3 v/v/v 75:20:5 (500 mL), 50:45:5 (400 mL) to afford an off-white solid (0.54 g, 89%): TLC Rf=0.35 (silica, 50:45:5 v/v/v hexanes/EtOAc/NEt3); 1H NMR (600 MHz, CDCl3) δ 7.80 (s, 1H), 6.54 (s, 1H), 4.23 (s, 2H), 3.24 (q, 2H, J=7.2 Hz), 3.15 (t, 2H, J=7.2 Hz) 2.42 (s, 3H), 1.51 (m, 2H), 1.30 (sextet, 2H, J=7.5 Hz), 1.14 (t, 3H, J=7.2 Hz), 0.93 (t, 3H, J=7.5 Hz); 13C NMR (150 MHz, CDCl3) δ 165.13, 157.36, 155.81, 150.86, 115.74, 111.69, 51.01, 46.50, 42.89, 30.03, 24.46, 20.44, 14.06, 13.15; HRMS (ESI) [MH]+ Calcd for C14H22ON335Cl2: 318.1134. found: 318.1131

Synthesis of Compounds XXXII and XXXIII Using Bromoacetic Anhydride.

3-Amino-4-(N-butyl-N-ethylamino)-2-chloro-6-methyl-pyridine (XXIX) (0.53 g, 2.19 mmol), bromoacetic anhydride (3.53 g, 13.58 mmol, 6.2 equiv.), iPr2NEt (0.57 mL, 3.27 mmol, 1.5 equiv.), and CHCl3 were stirred at reflux under Ar(g) for 21 h. The solvent was removed to give a brown syrup that was vacuum flash chromatographed on silica (13 cm h×4 cm i.d.): CH2Cl2 (150 mL), hexanes (100 mL), hexanes/EtOAc/NEt3 v/v/v 90:8:2 (100 mL), 75:20:5 (400 mL), 50:45:5 (300 mL) to give an off-white solid (0.50 g) that was further purified by radial chromatography (4 mm silica): hexanes (25 mL), hexanes/EtOAc/NEt3 v/v/v 95:4:1 (100 mL), 90:8:2 (250 mL), 85:12:3 (100 mL), 80:16:4 (100 mL) to afford two white solids: compound XXXII (0.18 g, 32%) and compound XXXIII (27 mg, 5%). Compound XXXII. 1H NMR (600 MHz, CDCl3) δ 7.72 (br s, 1H), 6.32 (s, 1H), 4.01 (s, 2H), 3.26 (t, 2H, J=7.5 Hz), 2.40 (s, 3H), 1.61 (quintet, 2H, J=7.5 Hz) 1.41 (sextet, 2H, J=7.5 Hz), 1.00 (t, 3H, J=7.5 Hz); HRMS (ESI) [MH]+ Calcd for C12H17ON335Cl: 254.1055. found: 254.1051. Compound XXXIII. 1H NMR (600 MHz, CDCl3) δ 7.75 (br s, 1H), 6.35 (s, 1H), 3.99 (s, 2H), 3.36 (q, 2H, J=7.2 Hz), 2.40 (s, 3H), 1.23 (t, 3H, J=7.2 Hz); HRMS (ESI) [MH]+ Calcd for C10H13ON335Cl: 226.0742. found: 226.0738.

4-(N-Butyl-N-ethylamino)-3-(2-(benzylamino)acetamido)-2-chloro-6-methyl-pyridine (17223)

4-(N-Butyl-N-ethylamino)-3-(2-chloroacetamido)-2-chloro-6-methyl-pyridine (XXX) (0.12 g, 3.77×10−4 mol), benzylamine (0.25 mL, 2.29 mmol, 6.1 equiv.), iPr2NEt (0.10 mL, 5.74×10−4 mol, 1.5 equiv.) and CH3CN (10 mL) were stirred at reflux under Ar(g) for 21 h. The solvent was removed to give a residue that was dissolved in CH2Cl2, poured onto dry silica (43 mm h×43 mm i.d.), and eluted under vacuum: CH2Cl2 (50 mL), hexanes (50 mL), hexanes/EtOAc/NEt3 v/v/v 75:20:5 (100 mL), 50:45:5 (200 mL) to afford 0.11 g (75%) of a colorless syrup: 1H NMR (600 MHz, CDCl3) δ 8.72 (br s, 1H), 7.35 (m, 4H), 7.30 (m, 1H), 6.53 (s, 1H), 3.93 (s, 2H), 3.49 (s, 2H), 3.22 (q, 2H, J=7.2 Hz), 3.14 (t, 2H, J=7.5 Hz), 2.42 (s, 3H), 1.95 (br s, 1H), 1.50 (m, 2H), 1.28 (sextet, 2H, J=7.5 Hz), 1.11 (t, 3H, J=7.2 Hz), 0.91 (t, 3H, J=7.5 Hz); HRMS (ESI) [MH]+ Calcd for C21H30ON435Cl: 389.2103. found: 389.2099.

4-(N-Benzyl)-8-(butylethylamino)-6-methyl-3,4-dihydro-1H-pyrido[2,3-b]pyrazin-2-one (8374)

4-(N-Butyl-N-ethylamino)-3-(2-(benzylamino)acetamido)-2-chloro-6-methyl-pyridine (XXX) (0.11 g, 2.83×10−4 mol), iPr2NEt (0.10 mL, 5.74×10−4 mol, 2 equiv), and nBuOH (40 mL) were stirred at reflux under Ar(g) for 64 h. The solvent was removed azeotropically with heptane to give a colorless syrup that was dissolved in CH2Cl2, poured onto dry silica (43 mm h×43 mm i.d.), and eluted under vacuum: CH2Cl2 (50 mL), hexanes (50 mL), hexanes/EtOAc/NEt3 v/v/v 90:8:2 (100 mL), 75:20:5 (100 mL), 50:45:5 (200 mL) to afford 80 mg (80%) of a colorless residue: 1H NMR (600 MHz, CDCl3) δ 7.89 (br s, 1H), 7.37 (d, 2H, J=7.2 Hz), 7.33 (t, 2H, J=7.2 Hz), 7.28 (d, 1H, J=7.2 Hz), 6.33 (s, 1H), 4.82 (s, 2H), 3.88 (s, 2H), 2.92 (q, 2H, J=7.2 Hz), 2.86 (t, 2H, J=7.2 Hz), 2.37 (s, 3H), 1.37 (m, 2H), 1.27 (sextet, 2H, J=7.2 Hz), 0.99 (t, 3H, J=7.2 Hz), 0.88 (t, 3H, J=7.2 Hz); HRMS (ESI) [MH]+ Calcd for C21H290N4: 353.2336. found: 353.2329; HPLC: tR=17.2 min (Waters XTerra+guard, 70:30:0.1 v/v/v MeOH/H2O/NEt3, 9.2 mL/min).

4-(N-Benzyl)-8-(butylethylamino)-6-methyl-3,4-dihydro-1H-pyrido[2,3-b]pyrazin-2-one HCl salt (8374.HCl)

4-(N-Benzyl)-8-(butylethylamino)-6-methyl-3,4-dihydro-1H-pyrido[2,3-b]pyrazin-2-one (8374) (71 mg, 2.01×10−4 mol) was dissolved in EtOEt (3 mL) and cooled to 0° C. under Ar(g). HCl (2.0 M in EtOEt, 0.2 mL, 0.4 mmol, 2 equiv.) was added dropwise, the mixture was stirred for 5 min, filtered, and the white solid was dried under vacuum (71 mg, 91%). X-ray quality crystals were grown by dissolving 5.6 mg of the white solid in MeOH (1 mL) and then allowing the MeOH to slowly evaporate. 1H NMR (600 MHz, CDCl3) δ 7.81 (br s, 1H), 7.35 (m, 5H), 6.33 (s, 1H), 5.39 (s, 2H), 4.01 (s, 2H), 3.24 (q, 2H, J=7.2 Hz), 3.16 (t, 2H, J=7.5 Hz), 3.07 (s, 3H), 1.50 (m, 2H), 1.30 (sextet, 2H, J=7.5 Hz), 1.15 (t, 3H, J=7.2 Hz), 0.92 (t, 3H, J=7.2 Hz).

Compounds 8375 and 8376 were prepared in a similar manner as compound 8374, and compounds (R/S)-8404, (R)-8404, (S)-8404, and (S)-8409 were also prepared in the same manner except that cyclohexanol was used in place of nBuOH.

Compound 8375. 1H NMR (600 MHz, CDCl3) δ 7.88 (br s, 1H), 7.40 (m, 2H), 7.20 (dd, 1H, J=1.8 Hz, J=8.4 Hz), 6.34 (s, 1H), 4.89 (s, 2H), 3.97 (s, 2H), 2.94 (q, 2H, J=7.2 Hz), 2.87 (t, 2H, J=7.2 Hz), 2.34 (s, 3H), 1.37 (m, 2H), 1.28 (sextet, 2H, J=7.2 Hz), 0.99 (t, 3H, J=7.2 Hz), 0.88 (t, 3H, J=7.2 Hz); HRMS (ESI) [MH]+ Calcd for C21H27ON435Cl2: 421.1556. found: 421.1552.

Compound 8376. 1H NMR (600 MHz, CDCl3) δ 7.87 (br s, 1H), 7.42 (d, 1H, J=8.4 Hz), 6.46 (m, 1H), 6.44 (d, 1H, J=2.4 Hz), 6.28 (s, 1H), 4.74 (s, 2H), 4.00 (s, 2H), 3.82 (s, 3H), 3.80 (s, 3H), 2.90 (q, 2H, J=7.2 Hz), 2.84 (t, 2H, J=7.2 Hz), 2.37 (s, 3H), 1.34 (m, 2H), 1.26 (sextet, 2H, J=7.2 Hz), 0.97 (t, 3H, J=7.2 Hz), 0.87 (t, 3H, J=7.2 Hz); HRMS (APCI) [MH]+ Calcd for C23H33O3N4: 413.2547. found: 413.2540; HPLC: tR=3.5 min (XTerra+guard, 70:30:0.1 v/v/v MeOH/H2O/NEt3, 9.2 mL/min).

Compound (R/S)-8404. 1H NMR (600 MHz, CDCl3) δ 7.84 (br s, 1H), 7.41 (d, 2H, J=7.8 Hz), 7.33 (t, 2H, J=7.8 Hz), 7.26 (t—partially obscured by CHCl3 solvent peak, 1H), 6.31 (overlapping s+q, 2H, J=7.2 Hz), 3.86 (d, 1H, J=16.2 Hz), 3.54 (d, 1H, J=16.2 Hz), 2.92 (q, 2H, J=7.2 Hz), 2.86 (t, 2H, J=7.2 Hz), 2.38 (s, 3H), 1.57 (d, 3H, J=7.2 Hz), 1.37 (m, 2H), 1.27 (sextet, 2H, J=7.2 Hz), 0.99 (t, 3H, J=7.2 Hz), 0.88 (t, 3H, J=7.2 Hz); HRMS (ESI) [MH]+ Calcd for C22H31ON4: 367.2492. found: 367.2490.

Compound (R)-8404. 1H NMR (600 MHz, CDCl3) δ 7.85 (br s, 1H), 7.41 (d, 2H, J=7.8 Hz), 7.33 (t, 2H, J=7.8 Hz), 7.26 (t, 1H, J=7.8 Hz), 6.32 (overlapping s+q, 2H, J=7.2 Hz), 3.86 (d, 1H, J=16.2 Hz), 3.55 (d, 1H, J=16.2 Hz), 2.93 (q, 2H, J=7.2 Hz), 2.87 (t, 2H, J=7.2 Hz), 2.38 (s, 3H), 1.57 (d, 3H, J=7.2 Hz), 1.37 (m, 2H), 1.27 (sextet, 2H, J=7.2 Hz), 0.99 (t, 3H, J=7.2 Hz), 0.88 (t, 3H, J=7.2 Hz); HRMS (ESI) [MH]+ Calcd for C22H31ON4: 367.2492. found: 367.2490.

Compound (S)-8404. 1H NMR (600 MHz, CDCl3) δ 7.84 (br s, 1H), 7.41 (d, 2H, J=7.8 Hz), 7.33 (t, 2H, J=7.8 Hz), 7.26 (t, 1H, J=7.8 Hz), 6.31 (overlapping s+q, 2H, J=7.2 Hz), 3.86 (d, 1H, J=16.2 Hz), 3.54 (d, 1H, J=16.2 Hz), 2.93 (q, 2H, J=7.2 Hz), 2.87 (t, 2H, J=7.2 Hz), 2.38 (s, 3H), 1.57 (d, 3H, J=7.2 Hz), 1.37 (m, 2H), 1.27 (sextet, 2H, J=7.2 Hz), 0.99 (t, 3H, J=7.2 Hz), 0.88 (t, 3H, J=7.2 Hz); HRMS (ESI) [MH]+ Calcd for C22H31ON4: 367.2492. found: 367.2490.

Compound (S)-8409. 1H NMR (600 MHz, CDCl3) δ 7.82 (br s, 1H), 7.34 (d, 2H, J=8.4 Hz), 6.86 (d, 2H, J=8.4 Hz), 6.31 (s, 1H), 6.25 (q, 1H, J=7.2 Hz), 3.83 (d, 1H, J=16.2 Hz), 3.80 (s, 3H), 3.53 (d, 1H, J=16.2 Hz), 2.92 (q, 2H, J=7.2 Hz), 2.86 (t, 2H, J=7.2 Hz), 2.38 (s, 3H), 1.54 (d, 3H, J=7.2 Hz), 1.37 (m, 2H), 1.27 (sextet, 2H, J=7.2 Hz), 0.99 (t, 3H, J=7.2 Hz), 0.88 (t, 3H, J=7.2 Hz).

TABLE 1
Substituent list for compounds of general structure VI.
VI
embedded image
Compound #R1 = R2 =R3 =
1BuEtH
2BuEt2-t-Bu
3BuEt2-Br
4BuEt3-Br
5BuEt4-Br
6BuEt2-I
7BuEt3-I
8BuEt4-I
9BuEt2-SnMe3
10BuEt3-SnMe3
11BuEt4-SnMe3
12BuEt2-Me
13BuEt3-Me
14BuEt4-Me
15BuEt2-OH
16BuEt3-OH
17BuEt4-OH
18BuEt2-OMe
19BuEt3-OMe
20BuEt4-OMe
21BuEt2-OMeF
22BuEt3-OMeF
23BuEt4-OMeF
24BuEt2-OCF3
25BuEt3-OCF3
26BuEt4-OCF3
27BuEt2-OEtF
28BuEt3-OEtF
29BuEt4-OEtF
30BuEt2-OPrF
31BuEt3-OPrF
32BuEt4-OPrF
33BuEt2-SH
34BuEt3-SH
35BuEt4-SH
36BuEt2-SMe
37BuEt3-SMe
38BuEt4-SMe
39BuEt2-SMeF
40BuEt3-SMeF
41BuEt4-SMeF
42BuEt2-SCF3
43BuEt3-SCF3
44BuEt4-SCF3
45BuEt2-SEtF
46BuEt3-SEtF
47BuEt4-SEtF
48BuEt2-SPrF
49BuEt3-SPrF
50BuEt4-SPrF
51BuEt2-OMe, 4-OMe
52BuEt2-Me, 5-OH
53BuEt2-Me, 5-OMe
54BuEt2-Me, 5-OMeF
55BuEt2-Me, 5-OEtF
56BuEt2-Me, 5-OPrF
57BuEt2-Me, 4-OH
58BuEt2-Me, 4-OMeF
59BuEt2-Me, 4-OCF3
60BuEt2-Me, 4-OEtF
61BuEt2-Me, 4-OPrF
62BuEt2-OH, 4-Me
63BuEt2-OMe, 4-Me
64BuEt2-OMeF, 4-Me
65BuEt2-OCF3, 4-Me
66BuEt2-OEtF, 4-Me
67BuEt2-OPrF, 4-Me
68BuEt2-Cl, 4-OH
69BuEt2-Cl, 4-OMeF
70BuEt2-Cl, 4-OCF3
71BuEt2-Cl, 4-OEtF
72BuEt2-Cl, 4-OPrF
73BuEt2-F, 4-F
74BuEt2-Cl, 4-F
75BuEt2-Cl, 4-NO2
76BuEt2-Cl, 4-NH2
77BuEt2-Cl, 4-NHMe
78BuEt2-Cl, 4-NMe2
79BuEt2-Cl, 4-NMe3OTf
80BuEt2-Cl, 4-NMe3I
81BuEt2-Cl, 5-F
82BuEt2-Cl, 5-NO2
83BuEt2-Cl, 5-NH2
84BuEt2-Cl, 5-NHMe
85BuEt2-Cl, 5-NMEe2
86BuEt2-Cl, 5-NMe3OTf
87BuEt2-Cl, 5-NMe3I
88BuEt2-F, 4-Cl
89BuEt2-NO2, 4-Cl
90BuEt2-NH2, 4-Cl
91BuEt2-NHMe, 4-Cl
92BuEt2-NMe2, 4-Cl
93BuEt2-NMe3OTf, 4-Cl
94BuEt2-NMe3I, 4-Cl
95BuEt2-F, 5-Cl
96BuEt2-NO2, 5-Cl
97BuEt2-NH2, 5-Cl
98BuEt2-NHMe, 5-Cl
99BuEt2-NMe2, 5-Cl
100BuEt2-NMe3OTf, 5-Cl
101BuEt2-NMe3I, 5-Cl
102BuEt2-Br, 4-F
103BuEt2-Br, 4-NO2
104BuEt2-Br, 4-NH2
105BuEt2-Br, 4-NHMe
106BuEt2-Br, 4-NMe2
107BuEt2-Br, 4-
NMe3OTf
108BuEt2-Br, 4-NMe3I
109BuEt2-Br, 5-F
110BuEt2-Br, 5-NO2
111BuEt2-Br, 3-NH2
112BuEt2-Br, 5-NHMe
113BuEt2-Br, 5-NMe2
114BuEt2-Br, 5-
NMe3OTf
115BuEt2-Br, 5-NMe3I
116BuEt2-F, 4-Br
117BuEt2-NO2, 4-Br
118BuEt2-NH2, 4-Br
119BuEt2-NHMe, 4-Br
120BuEt2-NMe2, 4-Br
121BuEt2-NMe3OTf, 4-
Br
122BuEt2-NMe3I, 4-Br
123BuEt2-I, 4-F
124BuEt2-I, 4-NO2
125BuEt2-I, 4-NH2
126BuEt2-I, 4-NHMe
127BuEt2-I, 4-NMe2
128BuEt2-I, 4-NMe3OTf
129BuEt2-I, 4-NMe3I
130BuEt2-F, 4-I
131BuEt2-NO2, 4-I
132BuEt2-NH2,4-I
133BuEt2-NHMe, 4-I
134BuEt2-NMe2, 4-I
135BuEt2-NMe3OTf, 4-I
136BuEt2-NMe3I, 4-I
137BuEt2-Me, 3-F
138BuEt2-Me, 3-NO2
139BuEt2-Me, 3-NH2
140BuEt2-Me, 3-NHMe
141BuEt2-Me, 3-NMe2
142BuEt2-Me, 3-
NMe3OTf
143BuEt2-Me, 3-NMe3I
144BuEt2-Me, 4-F
145BuEt2-Me, 4-NO2
146BuEt2-Me, 4-NH2
147BuEt2-Me, 4-NHMe
148BuEt2-Me, 4-NMe2
149BuEt2-Me, 4-
NMe3OTf
150BuEt2-Me, 4-NMe3I
151BuEt2-Me, 5-F
152BuEt2-Me, 5-NO2
153BuEt2-Me, 5-NH2
154BuEt2-Me, S-NHMe
155BuEt2-Me, 5-NMe2
156BuEt2-Me, 5-
NMe3OTf
157BuEt2-Me, 5-NMe3I
158BuEt2-F, 4-Me
159BuEt2-NO2, 4-Me
160BuEt2-NH2, 4-Me
161BuEt2-NHMe, 4-Me
162BuEt2-NMe2, 4-Me
163BuEt2-NMe3, 4-Me
164BuEt2-NMe3OTf, 4-
Me
165BuEt2-NMe3I, 4-Me
166BuEt2-SnMe3, 4-F
167BuEt2-SnMe3, 5-F
168BuEt2-F, 4-SnMe3
169BuEt2-Br, 6-Cl, 4-F
170BuEt2-Br, 6-Cl, 4-
NO2
171BuEt2-Br, 6-Cl, 4-
NH2
172BuEt2-Br, 6-Cl, 4-
NHMe
173BuEt2-Br, 6-Cl, 4-
NMe2
174BuEt2-Br, 6-Cl 4-
NMe2OTf
175BuEt2-Br, 6-Cl, 4-
NMe3I
176BuEt2-Me, 6-Cl, 4-F
177BuEt2-SnMe3, 6-Cl, 4-
F
178BuEt2-Cl, 4-Me
179BuEt2-Cl, 4-Br
180BuEt2-Cl, 4-SnMe3
181BuEt2-Br, 4-Cl
182BuEt2-SnMe3, 4-Cl
183BuEt2-Me, 4-Cl
184BuEt2-Br, 4-Br
185BuEt2-Br, 4-Me
186BuEt2-Br, 4-SnMe3
187BuEt2-SnMe3, 4-Br
188BuEt2-Me, 4-Br
189BuEt2-Me, 4-SnMe3
190BuEt2-SnMe3, 4-Me
191BuEt2-Me, 4-Me
192BuEt2-Et, 4-Br
193BuEt2-Et, 4-SnMe3,
194BuEt2-Et, 4-Me
195BuEt2-Me, 4-Br, 6-Me
196BuEt2-Me, 4-SnMe3,
6-Me
197BuEt2-Et, 6-Me
198BuEt2-SnMe3,4-i-Pr
199BuEt2-Me, 4-i-Pr
200BuEt2-Br, 4-Br, 6-Br
201BuEt2-Br, 4-Me, 6-Br
202BuEt2-Br, 4-SnMe3,
6-Br
203BuEt2-SnMe3, 4-Br,
6-Br
204BuEt2-Br, 4-Br, 6-Me
205BuEt2-Br, 4-CF3, 6-Br
206BuEt2-Br, 4-Br, 6-CF3
207BuEt2-CF3, 4-CF3
208BuEt2-Cl, 4-CF3
209BuEt2-CF3, 4-Cl
210BuEt2-Br, 4-CF3
211BuEt2-SnMe3, 4-CF3
212BuEt2-Me, 4-CF3
213BuEt2-CF3, 4-Br
214BuEt2-CF3, 4-SnMe3
215BuEt2-CF3, 4-Me
216BuEt2-Br, 4-OH
217BuEt2-Br, 4-OMe
218BuEt2-Br, 4 OMeF
219BuEt2-Br, 4-OCF3
220BuEt2-Br, 4-OEtF
221BuEt2-Br, 4-OPrF
222BuEt2-OH, 4-Br
223BuEt2-OMe, 4-Br
224BuEt2-OMeF, 4-Br
225BuEt2-OCF3, 4-Br
226BuEt2-OEtF, 4-Br
227BuEt2-OPrF, 4-Br
228BuEt2-I, 4-OH
229BuEt2-I, 4-OMe
230BuEt2-I, 4-OMeF
231BuEt2-I, 4-OCF3
232BuEt2-I, 4-OEtF
233BuEt2-I, 4-OPrF
234BuEt2-OH, 4-I
235BuEt2-OMe, 4-I
236BuEt2-OMeF, 4-I
237BuEt2-OCF3, 4-I
238BuEt2-OEtF, 4-I
239BuEt2-OPrF, 4-I
240BuEt2-SnMe3, 4-OH
241BuEt2-SnMe3, 4-OMe
242BuEt2-SnMe3, 4-
OMeF
243BuEt2-SnMe3, 4-OCF3
244BuEt2-SnMe3, 4-OEtF
245BuEt2-SnMe3, 4-OPrF
246BuEt2-OH, 4-SnMe3
247BuEt2-OMe, 4-SnMe3
248BuEt2-OMeF, 4-
SnMe3
249BuEt2-OCF3, 4-SnMe3
250BuEt2-OEtF, 4-SnMe3
251BuEt2-OPrF, 4-SnMe3
252PrPrH
253PrPr2-t-Bu
254PrPr2-Br
255PrPr3-Br
256PrPr4-Br
257PrPr2-I
258PrPr3-I
259PrPr4-I
260PrPr2-SnMe3
261PrPr3-SnMe3
262PrPr4-SnMe3
263PrPr2-Me
264PrPr3-Me
265PrPr4-Me
266PrPr2-OH
267PrPr3-OH
268PrPr4-OH
269PrPr2-OMe
270PrPr3-OMe
271PrPr4-OMe
272PrPr2-OMeF
273PrPr3-OMeF
274PrPr4-OMeF
275PrPr2-OCF3
276PrPr3-OCF3
277PrPr4-OCF3
278PrPr2-OEtF
279PrPr3-OEtF
280PrPr4-OEtF
281PrPr2-OPrF
282PrPr3-OPrF
283PrPr4-OPrF
284PrPr2-SH
285PrPr3-SH
286PrPr4-SH
287PrPr2-SMe
288PrPr3-SMe
289PrPr4-SMe
290PrPr2-SMeF
291PrPr3-SMeF
292PrPr4-SMeF
293PrPr2-SCF3
294PrPr3-SCF3
295PrPr4-SCF3
296PrPr2-SEtF
297PrPr3-SEtF
298PrPr4-SEtF
299PrPr2-SPrF
300PrPr3-SPrF
301PrPr4-SPrF
302PrPr2-OMe, 4-OMe
303PrPr2-Me, 5-OH
304PrPr2-Me, 5-OMe
305PrPr2-Me, 5-OMeF
306PrPr2-Me, 5-OEtF
307PrPr2-Me, 5-OPrF
308PrPr2-Me, 4-OH
309PrPr2-Me, 4-OMe
310PrPr2-Me, 4-OMeF
311PrPr2-Me, 4-OCF3
312PrPr2-Me, 4-OEtF
313PrPr2-Me, 4-OPrF
314PrPr2-OH, 4-Me
315PrPr2-OMe, 4-Me
316PrPr2-OMeF, 4-Me
317PrPr2-OCF3, 4-Me
318PrPr2-OEtF, 4-Me
319PrPr2-OPrF, 4-Me
320PrPr2-Cl, 4-OH
321PrPr2-Cl, 4-OMe
322PrPr2-Cl, 4-OMeF
323PrPr2-Cl, 4-OCF3
324PrPr2-Cl, 4-OEtF
325PrPr2-Cl, 4-OPrF
326PrPr2-F, 4-F
327PrPr2-Cl, 4-Cl
328PrPr2-Cl, 4-F
329PrPr2-Cl, 4-NO2
330PrPr2-Cl, 4-NH2
331PrPr2-Cl, 4-NHMe
332PrPr2-Cl, 4-NMe2
333PrPr2-Cl, 4-NMe3OTf
334PrPr2-Cl, 4-NMe3I
335PrPr2-Cl, 5-F
336PrPr2-Cl, 5-NO2
337PrPr2-Cl, 5-NH2
338PrPr2-Cl, 5-NHMe
339PrPr2-Cl, 5-NMe2
340PrPr2-Cl, 5-NMe3OTf
341PrPr2-Cl, 5-NMe3I
342PrPr2-F, 4-Cl
343PrPr2-NO2, 4-Cl
344PrPr2-NH2, 4-Cl
345PrPr2-NHMe3, 4-Cl
346PrPr2-NMe2, 4-Cl
347PrPr2-NMe3OTf, 4-Cl
348PrPr2-NMe3I, 4-Cl
349PrPr2-F, 5-Cl
350PrPr2-NO2, 5-Cl
351PrPr2-NH2, 5-Cl
352PrPr2-NHMe, 5-Cl
353PrPr2-NMe2, 5-Cl
354PrPr2-NMe3OTf, 5-Cl
355PrPr2-NMe3I, 5-Cl
356PrPr2-Br, 4-F
357PrPr2-Br, 4-NO2
358PrPr2-Br, 4-NH2
359PrPr2-Br, 4-NHMe
360PrPr2-Br, 4-NMe2
361PrPr2-Br, 4-
NMe3OTf
362PrPr2-Br, 4-NMe3I
363PrPr2-Br, 5-F
364PrPr2-Br, 5-NO2
365PrPr2-Br, 5-NH2
366PrPr2-Br, 5-NHMe
367PrPr2-Br, 5-NMe2
368PrPr2-Br, 5-
NMe3OTf
369PrPr2-Br, 5-NMe3I
370PrPr2-F, 4-Br
371PrPr2-NO2, 4-Br
372PrPr2-NH2, 4-Br
373PrPr2-NHMe, 4-Br
374PrPr2-NMe2, 4-Br
375PrPr2-NMe3OTf, 4-
Br
376PrPr2-NMe3I, 4-Br
377PrPr2-I, 4-F
378PrPr2-I, 4-NO2
379PrPr2-I, 4-NH2
380PrPr2-I, 4-NHMe
381PrPr2-I, 4-NMe2
382PrPr2-I, 4-NMe3OTf
383PrPr2-I, 4-NMe3I
384PrPr2-F, 4-I
385PrPr2-NO2, 4-I
386PrPr2-NH2,4-I
387PrPr2-NHMe, 4-I
388PrPr2-NMe2, 4-I
389PrPr2-NMe3OTf, 4-I
390PrPr2-NMe3I, 4-I
391PrPr2-Me, 3-F
392PrPr2-Me, 3-NO2
393PrPr2-Me, 3-NH2
394PrPr2-Me, 3-NHMe
395PrPr2-Me, 3-NMe2
396PrPr2-Me, 3-
NMe3OTf
397PrPr2-Me, 3-NMe3I
398PrPr2-Me, 4-F
399PrPr2-Me, 4-NO2
400PrPr2-Me, 4-NH2
401PrPr2-Me, 4-NHMe
402PrPr2-Me, 4-NMe2
403PrPr2-Me, 4-
NMe3OTf
404PrPr2-Me, 4-NMe3I
405PrPr2-Me, 5-F
406PrPr2-Me, 5-NO2
407PrPr2-Me, 5-NH2
408PrPr2-Me, 5-NHMe
409PrPr2-Me, 5-NMe2
410PrPr2-Me, 5-
NMe3OTf
411PrPr2-Me, 5-NMe3I
412PrPr2-F, 4-Me
413PrPr2-NO2, 4-Me
414PrPr2-NH2, 4-Me
415PrPr2-NHMe, 4-Me
416PrPr2-NMe2, 4-Me
417PrPr2-NMe3, 4-Me
418PrPr2-NMe3OTf, 4-
Me
419PrPr2-NMe3I, 4-Me
420PrPr2-SnMe3, 4-F
421PrPr2-SnMe3, 5-F
422PrPr2-F, 4-SnMe3
423PrPr2-Br, 6-Cl, 4-F
424PrPr2-Br, 6-Cl, 4-
NO2
425PrPr2-Br, 6-Cl, 4-
NH2
426PrPr2-Br, 6-Cl, 4-
NHMe
427PrPr2-Br, 6-Cl, 4-
NMe2
428PrPr2-Br, 6-Cl 4-
NMe2OTf
429PrPr2-Br, 6-Cl, 4-
NMe3I
430PrPr2-Me, 6-Cl, 4-F
431PrPr2-SnMe3, 6-Cl, 4-
F
432PrPr2-Cl, 4-Me
433PrPr2-Cl, 4-Br
434PrPr2-Cl, 4-SnMe3
435PrPr2-Br, 4-Cl
436PrPr2-SnMe3, 4-Cl
437PrPr2-Me, 4-Cl
438PrPr2-Br, 4-Br
439PrPr2-Br, 4-Me
440PrPr2-Br, 4-SnMe3
441PrPr2-SnMe3, 4-Br
442PrPr2-Me, 4-Br
443PrPr2-Me, 4-SnMe3
444PrPr2-SnMe3, 4-Me
445PrPr2-Me, 4-Me
446PrPr2-Et, 4-Br
447PrPr2-Et, 4-SnMe3
448PrPr2-Et, 4-Me
449PrPr2-Me, 4-Me, 6-Me
450PrPr2-Me, 4-Br, 6-Me
451PrPr2-Me, 4-SnMe3,
6-Me
452PrPr2-Et, 6-Me
453PrPr2-Br, 4-i-Pr
454PrPr2-SnMe3,4-i-Pr
455PrPr2-Me, 4-i-Pr
456PrPr2-Br, 4-Br, 6-Br
457PrPr2-Br, 4-Me, 6-Br
458PrPr2-Br, 4-SnMe3,
6-Br
459PrPr2-SnMe3, 4-Br,
6-Br
460PrPr2-Br, 4-Br, 6-Me
461PrPr2-Br, 4-CF3, 6-Br
462PrPr2-Br, 4-Br, 6-CF3
463PrPr2-CF3, 4-CF3
464PrPr2-Cl, 4-CF3
465PrPr2-CF3, 4-Cl
466PrPr2-Br, 4-CF3
467PrPr2-SnMe3, 4-CF3
468PrPr2-Me, 4-CF3
469PrPr2-CF3, 4-Br
470PrPr2-CF3, 4-SnMe3
471PrPr2-CF3, 4-Me
472PrPr2-Br, 4-OH
473PrPr2-Br, 4-OMe
474PrPr2-Br, 4 OMeF
475PrPr2-Br, 4-OCF3
476PrPr2-Br, 4-OEtF
477PrPr2-Br, 4-OPrF
478PrPr2-OH, 4-Br
479PrPr2-OMe, 4-Br
480PrPr2-OMeF, 4-Br
481PrPr2-OCF3, 4-Br
482PrPr2-OEtF, 4-Br
483PrPr2-OPrF, 4-Br
484PrPr2-I, 4-OH
485PrPr2-I, 4-OMe
486PrPr2-I, 4-OMeF
487PrPr2-I, 4-OCF3
488PrPr2-I, 4-OEtF
489PrPr2-I, 4-OPrF
490PrPr2-OH, 4-I
491PrPr2-OMe, 4-I
492PrPr2-OMeF, 4-I
493PrPr2-OCF3, 4-I
494PrPr2-OEtF, 4-I
495PrPr2-OPrF, 4-I
496PrPr2-SnMe3, 4-OH
497PrPr2-SnMe3, 4-OMe
498PrPr2-SnMe3, 4-
OMeF
499PrPr2-SnMe3, 4-OCF3
500PrPr2-SnMe3, 4-OEtF
501PrPr2-SnMe3, 4-OPrF
502PrPr2-OH, 4-SnMe3
503PrPr2-OMe, 4-SnMe3
504PrPr2-OMeF, 4-
SnMe3
505PrPr2-OCF3, 4-SnMe3
506PrPr2-OEtF, 4-SnMe3
507PrPr2-OPrF, 4-SnMe3
508PrPr—FH
509PrPr—F2-t-Bu
510PrPr—F2-Br
511PrPr—F3-Br
512PrPr—F4-Br
513PrPr—F2-I
514PrPr—F3-I
515PrPr—F4-I
516PrPr—F2-SnMe3
517PrPr—F3-SnMe3
518PrPr—F4-SnMe3
519PrPr—F2-Me
520PrPr—F3-Me
521PrPr—F4-Me
522PrPr—F2-OH
523PrPr—F3-OH
524PrPr—F4-OH
525PrPr—F2-OMe
526PrPr—F3-OMe
527PrPr—F4-OMe
528PrPr—F2-OMeF
529PrPr—F3-OMeF
530PrPr—F4-OMeF
531PrPr—F2-OCF3
532PrPr—F3-OCF3
533PrPr—F4-OCF3
534PrPr—F2-OEtF
535PrPr—F3-OEtF
536PrPr—F4-OEtF
537PrPr—F2-OPrF
538PrPr—F3-OPrF
539PrPr—F4-OPrF
540PrPr—F2-SH
541PrPr—F3-SH
542PrPr—F4-SH
543PrPr—F2-SMe
544PrPr—F3-SMe
545PrPr—F4-SMe
546PrPr—F2-SMeF
547PrPr—F3-SMeF
548PrPr—F4-SMeF
549PrPr—F2-SCF3
550PrPr—F3-SCF3
551PrPr—F4-SCF3
552PrPr—F2-SEtF
553PrPr—F3-SEtF
554PrPr—F4-SEtF
555PrPr—F2-SPrF
556PrPr—F3-SPrF
557PrPr—F4-SPrF
558PrPr—F2-OMe, 4-OMe
559PrPr—F2-Me, 5-OH
560PrPr—F2-Me, 5-OMe
561PrPr—F2-Me, 5-OMeF
562PrPr—F2-Me, 5-OEtF
563PrPr—F2-Me, 5-OPrF
564PrPr—F2-Me, 4-OH
565PrPr—F2-Me, 4-OMe
566PrPr—F2-Me, 4-OMeF
567PrPr—F2-Me, 4-OCF3
568PrPr—F2-Me, 4-OEtF
569PrPr—F2-Me, 4-OPrF
570PrPr—F2-OH, 4-Me
571PrPr—F2-OMe, 4-Me
572PrPr—F2-OMeF, 4-Me
573PrPr—F2-OCF3, 4-Me
574PrPr—F2-OEtF, 4-Me
575PrPr—F2-OPrF, 4-Me
576PrPr—F2-Cl, 4-OH
577PrPr—F2-Cl, 4-OMe
578PrPr—F2-Cl, 4-OMeF
579PrPr—F2-Cl, 4-OCF3
580PrPr—F2-Cl, 4-OEtF
581PrPr—F2-Cl, 4-OPrF
582PrPr—F2-F, 4-F
583PrPr—F2-Cl, 4-Cl
584PrPr—F2-Cl, 4-F
585PrPr—F2-Cl, 4-NO2
586PrPr—F2-Cl, 4-NH2
587PrPr—F2-Cl, 4-NHMe
588PrPr—F2-Cl, 4-NMe2
589PrPr—F2-Cl, 4-NMe3OTf
590PrPr—F2-Cl, 4-NMe3I
591PrPr—F2-Cl, 5-F
592PrPr—F2-Cl, 5-NO2
593PrPr—F2-Cl, 5-NH2
594PrPr—F2-Cl, 5-NHMe
595PrPr—F2-Cl, 5-NMe2
596PrPr—F2-Cl, 5-NMe3OTf
597PrPr—F2-Cl, 5-NMe3I
598PrPr—F2-F, 4-Cl
599PrPr—F2-NO2, 4-Cl
600PrPr—F2-NH2, 4-Cl
601PrPr—F2-NHMe3, 4-Cl
602PrPr—F2-NMe2, 4-Cl
603PrPr—F2-NMe3OTf, 4-Cl
604PrPr—F2-NMe3I, 4-Cl
605PrPr—F2-F, 5-Cl
606PrPr—F2-NO2, 5-Cl
607PrPr—F2-NH2, 5-Cl
608PrPr—F2-NHMe, 5-Cl
609PrPr—F2-NMe2, 5-Cl
610PrPr—F2-NMe3OTf, 5-Cl
611PrPr—F2-NMe3I, 5-Cl
612PrPr—F2-Br, 4-F
613PrPr—F2-Br, 4-NO2
614PrPr—F2-Br, 4-NH2
615PrPr—F2-Br, 4-NHMe
616PrPr—F2-Br, 4-NMe2
617PrPr—F2-Br, 4-
NMe3OTf
618PrPr—F2-Br, 4-NMe3I
619PrPr—F2-Br, 5-F
620PrPr—F2-Br, 5-NO2
621PrPr—F2-Br, 5-NH2
622PrPr—F2-Br, 5-NHMe
623PrPr—F2-Br, 5-NMe2
624PrPr—F2-Br, 5-
NMe3OTf
625PrPr—F2-Br, 5-NMe3I
626PrPr—F2-F, 4-Br
627PrPr—F2-NO2, 4-Br
628PrPr—F2-NH2, 4-Br
629PrPr—F2-NHMe, 4-Br
630PrPr—F2-NMe2, 4-Br
631PrPr—F2-NMe3OTf, 4-
Br
632PrPr—F2-NMe3I, 4-Br
633PrPr—F2-I, 4-F
634PrPr—F2-I, 4-NO2
635PrPr—F2-I, 4-NH2
636PrPr—F2-I, 4-NHMe
637PrPr—F2-I, 4-NMe2
638PrPr—F2-I, 4-NMe3OTf
639PrPr—F2-I, 4-NMe3I
640PrPr—F2-F, 4-I
641PrPr—F2-NO2, 4-I
642PrPr—F2-NH2, 4-I
643PrPr—F2-NHMe, 4-I
644PrPr—F2-NMe2, 4-I
645PrPr—F2-NMe3OTf, 4-I
646PrPr—F2-NMe3I, 4-I
647PrPr—F2-Me, 3-F
648PrPr—F2-Me, 3-NO2
649PrPr—F2-Me, 3-NH2
650PrPr—F2-Me, 3-NHMe
651PrPr—F2-Me, 3-NMe2
652PrPr—F2-Me, 3-
NMe3OTf
653PrPr—F2-Me, 3-NMe3I
654PrPr—F2-Me, 4-F
655PrPr—F2-Me, 4-NO2
656PrPr—F2-Me, 4-NH2
657PrPr—F2-Me, 4-NHMe
658PrPr—F2-Me, 4-NMe2
659PrPr—F2-Me, 4-
NMe3OTf
660PrPr—F2-Me, 4-NMe3I
661PrPr—F2-Me, 5-F
662PrPr—F2-Me, 5-NO2
663PrPr—F2-Me, 5-NH2
664PrPr—F2-Me, 5-NHMe
665PrPr—F2-Me, 5-NMe2
666PrPr—F2-Me, 5-
NMe3OTf
667PrPr—F2-Me, 5-NMe3I
668PrPr—F2-F, 4-Me
669PrPr—F2-NO2, 4-Me
670PrPr—F2-NH2, 4-Me
671PrPr—F2-NHMe, 4-Me
672PrPr—F2-NMe2, 4-Me
673PrPr—F2-NMe3, 4-Me
674PrPr—F2-NMe3OTf, 4-
Me
675PrPr—F2-NMe3I, 4-Me
676PrPr—F2-SnMe3, 4-F
677PrPr—F2-SnMe3, 5-F
678PrPr—F2-F, 4-SnMe3
679PrPr—F2-Br, 6-Cl, 4-F
680PrPr—F2-Br, 6-Cl, 4-
NO2
681PrPr—F2-Br, 6-Cl, 4-
NH2
682PrPr—F2-Br, 6-Cl, 4-
NHMe
683PrPr—F2-Br, 6-Cl, 4-
NMe2
684PrPr—F2-Br, 6-Cl 4-
NMe3OTf
685PrPr—F2-Br, 6-Cl, 4-
NMe3I
686PrPr—F2-Me, 6-Cl, 4-F
687PrPr—F2-SnMe3, 6-Cl, 4-
F
688PrPr—F2-Cl, 4-Me
689PrPr—F2-Cl, 4-Br
690PrPr—F2-Cl, 4-SnMe3
691PrPr—F2-Br, 4-Cl
692PrPr—F2-SnMe3, 4-Cl
693PrPr—F2-Me, 4-Cl
694PrPr—F2-Br, 4-Br
695PrPr—F2-Br, 4-Me
696PrPr—F2-Br, 4-SnMe3
697PrPr—F2-SnMe3, 4-Br
698PrPr—F2-Me, 4-Br
699PrPr—F2-Me, 4-SnMe3
700PrPr—F2-SnMe3, 4-Me
701PrPr—F2-Me, 4-Me
702PrPr—F2-Et, 4-Br
703PrPr—F2-Et, 4-SnMe3
704PrPr—F2-Et, 4-Me
705PrPr—F2-Me, 4-Me, 6-Me
706PrPr—F2-Me, 4-Br, 6-Me
707PrPr—F2-Me, 4-SnMe3,
6-Me
708PrPr—F2-Et, 6-Me
709PrPr—F2-Br, 4-i-Pr
710PrPr—F2-SnMe3, 4-i-Pr
711PrPr—F2-Me, 4-i-Pr
712PrPr—F2-Br, 4-Br, 6-Br
713PrPr—F2-Br, 4-Me, 6-Br
714PrPr—F2-Br, 4-SnMe3,
6-Br
715PrPr—F2-SnMe3, 4-Br,
6-Br
716PrPr—F2-Br, 4-Br, 6-Me
717PrPr—F2-Br, 4-CF3, 6-Br
718PrPr—F2-Br, 4-Br, 6-CF3
719PrPr—F2-CF3, 4-CF3
720PrPr—F2-Cl, 4-CF3
721PrPr—F2-CF3, 4-Cl
722PrPr—F2-Br, 4-CF3
723PrPr—F2-SnMe3, 4-CF3
724PrPr—F2-Me, 4-CF3
725PrPr—F2-CF3, 4-Br
726PrPr—F2-CF3, 4-SnMe3
727PrPr—F2-CF3, 4-Me
728PrPr—F2-Br, 4-OH
729PrPr—F2-Br, 4-OMe
730PrPr—F2-Br, 4 OMeF
731PrPr—F2-Br, 4-OCF3
732PrPr—F2-Br, 4-OEtF
733PrPr—F2-Br, 4-OPrF
734PrPr—F2-OH, 4-Br
735PrPr—F2-OMe, 4-Br
736PrPr—F2-OMeF, 4-Br
737PrPr—F2-OCF3, 4-Br
738PrPr—F2-OEtF, 4-Br
739PrPr—F2-OPrF, 4-Br
740PrPr—F2-I, 4-OH
741PrPr—F2-I, 4-OMe
742PrPr—F2-I, 4-OMeF
743PrPr—F2-I, 4-OCF3
744PrPr—F2-I, 4-OEtF
745PrPr—F2-I, 4-OPrF
746PrPr—F2-OH, 4-I
747PrPr—F2-OMe, 4-I
748PrPr—F2-OMeF, 4-I
749PrPr—F2-OCF3, 4-I
750PrPr—F2-OEtF, 4-I
751PrPr—F2-OPrF, 4-I
752PrPr—F2-SnMe3, 4-OH
753PrPr—F2-SnMe3, 4-OMe
754PrPr—F2-SnMe3, 4-
OMeF
755PrPr—F2-SnMe3, 4-OCF3
756PrPr—F2-SnMe3, 4-OEtF
757PrPr—F2-SnMe3, 4-OPrF
758PrPr—F2-OH, 4-SnMe3
759PrPr—F2-OMe, 4-SnMe3
760PrPr—F2-OMeF, 4-
SnMe3
761PrPr—F2-OCF3, 4-SnMe3
762PrPr—F2-OEtF, 4-SnMe3
763PrPr—F2-OPrF, 4-SnMe3
764PrEt—FH
765PrEt—F2-t-Bu
766PrEt—F2-Br
767PrEt—F3-Br
768PrEt—F4-Br
769PrEt—F2-I
770PrEt—F3-I
771PrEt—F4-I
772PrEt—F2-SnMe3
773PrEt—F3-SnMe3
774PrEt—F4-SnMe3
775PrEt—F2-Me
776PrEt—F3-Me
777PrEt—F4-Me
778PrEt—F2-OH
779PrEt—F3-OH
780PrEt—F4-OH
781PrEt—F2-OMe
782PrEt—F3-OMe
783PrEt—F4-OMe
784PrEt—F2-OMeF
785PrEt—F3-OMeF
786PrEt—F4-OMeF
787PrEt—F2-OCF3
788PrEt—F3-OCF3
789PrEt—F4-OCF3
790PrEt—F2-OEtF
791PrEt—F3-OEtF
792PrEt—F4-OEtF
793PrEt—F2-OPrF
794PrEt—F3-OPrF
795PrEt—F4-OPrF
796PrEt—F2-SH
797PrEt—F3-SH
798PrEt—F4-SH
799PrEt—F2-SMe
800PrEt—F3-SMe
801PrEt—F4-SMe
802PrEt—F2-SMeF
803PrEt—F3-SMeF
804PrEt—F4-SMeF
805PrEt—F2-SCF3
806PrEt—F3-SCF3
807PrEt—F4-SCF3
808PrEt—F2-SEtF
809PrEt—F3-SEtF
810PrEt—F4-SEtF
811PrEt—F2-SPrF
812PrEt—F3-SPrF
813PrEt—F4-SPrF
814PrEt—F2-OMe, 4-OMe
815PrEt—F2-Me, 5-OH
816PrEt—F2-Me, 5-OMe
817PrEt—F2-Me, 5-OMeF
818PrEt—F2-Me, 5-OEtF
819PrEt—F2-Me, 5-OPrF
820PrEt—F2-Me, 4-OH
821PrEt—F2-Me, 4-OMe
822PrEt—F2-Me, 4-OMeF
823PrEt—F2-Me, 4-OCF3
824PrEt—F2-Me, 4-OEtF
825PrEt—F2-Me, 4-OPrF
826PrEt—F2-OH, 4-Me
827PrEt—F2-OMe, 4-Me
828PrEt—F2-OMeF, 4-Me
829PrEt—F2-OCF3, 4-Me
830PrEt—F2-OEtF, 4-Me
831PrEt—F2-OPrF, 4-Me
832PrEt—F2-Cl, 4-OH
833PrEt—F2-Cl, 4-OMe
834PrEt—F2-Cl, 4-OMeF
835PrEt—F2-Cl, 4-OCF3
836PrEt—F2-Cl, 4-OEtF
837PrEt—F2-Cl, 4-OPrF
838PrEt—F2-F, 4-F
839PrEt—F2-Cl, 4-Cl
840PrEt—F2-Cl, 4-F
841PrEt—F2-Cl, 4-NO2
842PrEt—F2-Cl, 4-NH2
843PrEt—F2-Cl, 4-NHMe
844PrEt—F2-Cl, 4-NMe2
845PrEt—F2-Cl, 4-NMe3OTf
846PrEt—F2-Cl, 4-NMe3I
847PrEt—F2-Cl, 5-F
848PrEt—F2-Cl, 5-NO2
849PrEt—F2-Cl, 5-NH2
850PrEt—F2-Cl, 5-NHMe
851PrEt—F2-Cl, 5-NMe2
852PrEt—F2-Cl, 5-NMe3OTf
853PrEt—F2-Cl, 5-NMe3I
854PrEt—F2-F, 4-Cl
855PrEt—F2-NO2, 4-Cl
856PrEt—F2-NH2, 4-Cl
857PrEt—F2-NHMe3, 4-Cl
858PrEt—F2-NMe2, 4-Cl
859PrEt—F2-NMe3OTf, 4-Cl
860PrEt—F2-NMe3I, 4-Cl
861PrEt—F2-F, 5-Cl
862PrEt—F2-NO2, 5-Cl
863PrEt—F2-NH2, 5-Cl
864PrEt—F2-NHMe, 5-Cl
865PrEt—F2-NMe2, 5-Cl
866PrEt—F2-NMe3OTf, 5-Cl
867PrEt—F2-NMe3I, 5-Cl
868PrEt—F2-Br, 4-F
869PrEt—F2-Br, 4-NO2
870PrEt—F2-Br, 4-NH2
871PrEt—F2-Br, 4-NHMe
872PrEt—F2-Br, 4-NMe2
873PrEt—F2-Br, 4-
NMe3OTf
874PrEt—F2-Br, 4-NMe3I
875PrEt—F2-Br, 5-F
876PrEt—F2-Br, 5-NO2
877PrEt—F2-Br, 5-NH2
878PrEt—F2-Br, 5-NHMe
879PrEt—F2-Br, 5-NMe2
880PrEt—F2-Br, 5-
NMe3OTf
881PrEt—F2-Br, 5-NMe3I
882PrEt—F2-F, 4-Br
883PrEt—F2-NO2, 4-Br
884PrEt—F2-NH2, 4-Br
885PrEt—F2-NHMe, 4-Br
886PrEt—F2-NMe2, 4-Br
887PrEt—F2-NMe3OTf, 4-
Br
888PrEt—F2-NMe3I, 4-Br
889PrEt—F2-I, 4-F
890PrEt—F2-I, 4-NO2
891PrEt—F2-I, 4-NH2
892PrEt—F2-I, 4-NHMe
893PrEt—F2-I, 4-NMe2
894PrEt—F2-I, 4-NMe3OTf
895PrEt—F2-I, 4-NMe3I
896PrEt—F2-F, 4-I
897PrEt—F2-NO2, 4-I
898PrEt—F2-NH2, 4-I
899PrEt—F2-NHMe, 4-I
900PrEt—F2-NMe2, 4-I
901PrEt—F2-NMe3OTf, 4-I
902PrEt—F2-NMe3I, 4-I
903PrEt—F2-Me, 3-F
904PrEt—F2-Me, 3-NO2
905PrEt—F2-Me, 3-NH2
906PrEt—F2-Me, 3-NHMe
907PrEt—F2-Me, 3-NMe2
908PrEt—F2-Me, 3-
NMe3OTf
909PrEt—F2-Me, 3-NMe3I
910PrEt—F2-Me, 4-F
911PrEt—F2-Me, 4-NO2
912PrEt—F2-Me, 4-NH2
913PrEt—F2-Me, 4-NHMe
914PrEt—F2-Me, 4-NMe2
915PrEt—F2-Me, 4-
NMe3OTf
916PrEt—F2-Me, 4-NMe3I
917PrEt—F2-Me, 5-F
918PrEt—F2-Me, 5-NO2
919PrEt—F2-Me, 5-NH2
920PrEt—F2-Me, 5-NHMe
921PrEt—F2-Me, 5-NMe2
922PrEt—F2-Me, 5-
NMe3OTf
923PrEt—F2-Me, 5-NMe3I
924PrEt—F2-F, 4-Me
925PrEt—F2-NO2, 4-Me
926PrEt—F2-NH2, 4-Me
927PrEt—F2-NHMe, 4-Me
928PrEt—F2-NMe2, 4-Me
929PrEt—F2-NMe3, 4-Me
930PrEt—F2-NMe3OTf, 4-
Me
931PrEt—F2-NMe3I, 4-Me
932PrEt—F2-SnMe3, 4-F
933PrEt—F2-SnMe3, 5-F
934PrEt—F2-F, 4-SnMe3
935PrEt—F2-Br, 6-Cl, 4-F
936PrEt—F2-Br, 6-Cl, 4-
NO2
937PrEt—F2-Br, 6-Cl, 4-
NH2
938PrEt—F2-Br, 6-Cl, 4-
NHMe
939PrEt—F2-Br, 6-Cl, 4-
NMe2
940PrEt—F2-Br, 6-Cl 4-
NMe3OTf
941PrEt—F2-Br, 6-Cl, 4-
NMe3I
942PrEt—F2-Me, 6-Cl, 4-F
943PrEt—F2-SnMe3, 6-Cl, 4-
F
944PrEt—F2-Cl, 4-Me
945PrEt—F2-Cl, 4-Br
946PrEt—F2-Cl, 4-SnMe3
947PrEt—F2-Br, 4-Cl
948PrEt—F2-SnMe3, 4-Cl
949PrEt—F2-Me, 4-Cl
950PrEt—F2-Br, 4-Br
951PrEt—F2-Br, 4-Me
952PrEt—F2-Br, 4-SnMe3
953PrEt—F2-SnMe3, 4-Br
954PrEt—F2-Me, 4-Br
955PrEt—F2-Me, 4-SnMe3
956PrEt—F2-SnMe3, 4-Me
957PrEt—F2-Me, 4-Me
958PrEt—F2-Et, 4-Br
959PrEt—F2-Et, 4-SnMe3
960PrEt—F2-Et, 4-Me
961PrEt—F2-Me, 4-Me, 6-Me
962PrEt—F2-Me, 4-Br, 6-Me
963PrEt—F2-Me, 4-SnMe3,
6-Me
964PrEt—F2-Et, 6-Me
965PrEt—F2-Br, 4-i-Pr
966PrEt—F2-SnMe3, 4-i-Pr
967PrEt—F2-Me, 4-i-Pr
968PrEt—F2-Br, 4-Br, 6-Br
969PrEt—F2-Br, 4-Me, 6-Br
970PrEt—F2-Br, 4-SnMe3,
6-Br
971PrEt—F2-SnMe3, 4-Br,
6-Br
972PrEt—F2-Br, 4-Br, 6-Me
973PrEt—F2-Br, 4-CF3, 6-Br
974PrEt—F2-Br, 4-Br, 6-CF3
975PrEt—F2-CF3, 4-CF3
976PrEt—F2-Cl, 4-CF3
977PrEt—F2-CF3, 4-Cl
978PrEt—F2-Br, 4-CF3
979PrEt—F2-SnMe3, 4-CF3
980PrEt—F2-Me, 4-CF3
981PrEt—F2-CF3, 4-Br
982PrEt—F2-CF3, 4-SnMe3
983PrEt—F2-CF3, 4-Me
984PrEt—F2-Br, 4-OH
985PrEt—F2-Br, 4-OMe
986PrEt—F2-Br, 4-OMeF
987PrEt—F2-Br, 4-OCF3
988PrEt—F2-Br, 4-OEtF
989PrEt—F2-Br, 4-OPrF
990PrEt—F2-OH, 4-Br
991PrEt—F2-OMe, 4-Br
992PrEt—F2-OMeF, 4-Br
993PrEt—F2-OCF3, 4-Br
994PrEt—F2-OEtF, 4-Br
995PrEt—F2-OPrF, 4-Br
996PrEt—F2-I, 4-OH
997PrEt—F2-I, 4-OMe
998PrEt—F2-I, 4-OMeF
999PrEt—F2-I, 4-OCF3
1000PrEt—F2-I, 4-OEtF
1001PrEt—F2-I, 4-OPrF
1002PrEt—F2-OH, 4-I
1003PrEt—F2-OMe, 4-I
1004PrEt—F2-OMeF, 4-I
1005PrEt—F2-OCF3, 4-I
1006PrEt—F2-OEtF, 4-I
1007PrEt—F2-OPrF, 4-I
1008PrEt—F2-SnMe3, 4-OH
1009PrEt—F2-SnMe3, 4-OMe
1010PrEt—F2-SnMe3, 4-
OMeF
1011PrEt—F2-SnMe3, 4-OCF3
1012PrEt—F2-SnMe3, 4-OEtF
1013PrEt—F2-SnMe3, 4-OPrF
1014PrEt—F2-OH, 4-SnMe3
1015PrEt—F2-OMe, 4-SnMe3
1016PrEt—F2-OMeF, 4-
SnMe3
1017PrEt—F2-OCF3, 4-SnMe3
1018PrEt—F2-OEtF, 4-SnMe3
1019PrEt—F2-OPrF, 4-SnMe3
1020Pr—FEtH
1021Pr—FEt2-t-Bu
1022Pr—FEt2-Br
1023Pr—FEt3-Br
1024Pr—FEt4-Br
1025Pr—FEt2-I
1026Pr—FEt3-I
1027Pr—FEt4-I
1028Pr—FEt2-SnMe3
1029Pr—FEt3-SnMe3
1030Pr—FEt4-SnMe3
1031Pr—FEt2-Me
1032Pr—FEt3-Me
1033Pr—FEt4-Me
1034Pr—FEt2-OH
1035Pr—FEt3-OH
1036Pr—FEt4-OH
1037Pr—FEt2-OMe
1038Pr—FEt3-OMe
1039Pr—FEt4-OMe
1040Pr—FEt2-OMeF
1041Pr—FEt3-OMeF
1042Pr—FEt4-OMeF
1043Pr—FEt2-OCF3
1044Pr—FEt3-OCF3
1045Pr—FEt4-OCF3
1046Pr—FEt2-OEtF
1047Pr—FEt3-OEtF
1048Pr—FEt4-OEtF
1049Pr—FEt2-OPrF
1050Pr—FEt3-OPrF
1051Pr—FEt4-OPrF
1052Pr—FEt2-SH
1053Pr—FEt3-SH
1054Pr—FEt4-SH
1055Pr—FEt2-SMe
1056Pr—FEt3-SMe
1057Pr—FEt4-SMe
1058Pr—FEt2-SMeF
1059Pr—FEt3-SMeF
1060Pr—FEt4-SMeF
1061Pr—FEt2-SCF3
1062Pr—FEt3-SCF3
1063Pr—FEt4-SCF3
1064Pr—FEt2-SEtF
1065Pr—FEt3-SEtF
1066Pr—FEt4-SEtF
1067Pr—FEt2-SPrF
1068Pr—FEt3-SPrF
1069Pr—FEt4-SPrF
1070Pr—FEt2-OMe, 4-OMe
1071Pr—FEt2-Me, 5-OH
1072Pr—FEt2-Me, 5-OMe
1073Pr—FEt2-Me, 5-OMeF
1074Pr—FEt2-Me, 5-OEtF
1075Pr—FEt2-Me, 5-OPrF
1076Pr—FEt2-Me, 4-OH
1077Pr—FEt2-Me, 4-OMe
1078Pr—FEt2-Me, 4-OMeF
1079Pr—FEt2-Me, 4-OCF3
1080Pr—FEt2-Me, 4-OEtF
1081Pr—FEt2-Me, 4-OPrF
1082Pr—FEt2-OH, 4-Me
1083Pr—FEt2-OMe, 4-Me
1084Pr—FEt2-OMeF, 4-Me
1085Pr—FEt2-OCF3, 4-Me
1086Pr—FEt2-OEtF, 4-Me
1087Pr—FEt2-OPrF, 4-Me
1088Pr—FEt2-Cl, 4-OH
1089Pr—FEt2-Cl, 4-OMe
1090Pr—FEt2-Cl, 4-OMeF
1091Pr—FEt2-Cl, 4-OCF3
1092Pr—FEt2-Cl, 4-OEtF
1093Pr—FEt2-Cl, 4-OPrF
1094Pr—FEt2-F, 4-F
1095Pr—FEt2-Cl, 4-Cl
1096Pr—FEt2-Cl, 4-F
1097Pr—FEt2-Cl, 4-NO2
1098Pr—FEt2-Cl, 4-NH2
1099Pr—FEt2-Cl, 4-NHMe
1100Pr—FEt2-Cl, 4-NMe2
1101Pr—FEt2-Cl, 4-NMe3OTf
1102Pr—FEt2-Cl, 4-NMe3I
1103Pr—FEt2-Cl, 5-F
1104Pr—FEt2-Cl, 5-NO2
1105Pr—FEt2-Cl, 5-NH2
1106Pr—FEt2-Cl, 5-NHMe
1107Pr—FEt2-Cl, 5-NMe2
1108Pr—FEt2-Cl, 5-NMe3OTf
1109Pr—FEt2-Cl, 5-NMe3I
1110Pr—FEt2-F, 4-Cl
1111Pr—FEt2-NO2, 4-Cl
1112Pr—FEt2-NH2, 4-Cl
1113Pr—FEt2-NHMe3, 4-Cl
1114Pr—FEt2-NMe2, 4-Cl
1115Pr—FEt2-NMe3OTf, 4-Cl
1116Pr—FEt2-NMe3I, 4-Cl
1117Pr—FEt2-F, 5-Cl
1118Pr—FEt2-NO2, 5-Cl
1119Pr—FEt2-NH2, 5-Cl
1120Pr—FEt2-NHMe, 5-Cl
1121Pr—FEt2-NMe2, 5-Cl
1122Pr—FEt2-NMe3OTf, 5-Cl
1123Pr—FEt2-NMe3I, 5-Cl
1124Pr—FEt2-Br, 4-F
1125Pr—FEt2-Br, 4-NO2
1126Pr—FEt2-Br, 4-NH2
1127Pr—FEt2-Br, 4-NHMe
1128Pr—FEt2-Br, 4-NMe2
1129Pr—FEt2-Br, 4-
NMe3OTf
1130Pr—FEt2-Br, 4-NMe3I
1131Pr—FEt2-Br, 5-F
1132Pr—FEt2-Br, 5-NO2
1133Pr—FEt2-Br, 5-NH2
1134Pr—FEt2-Br, 5-NHMe
1135Pr—FEt2-Br, 5-NMe2
1136Pr—FEt2-Br, 5-
NMe3OTf
1137Pr—FEt2-Br, 5-NMe3I
1138Pr—FEt2-F, 4-Br
1139Pr—FEt2-NO2, 4-Br
1140Pr—FEt2-NH2, 4-Br
1141Pr—FEt2-NHMe, 4-Br
1142Pr—FEt2-NMe2, 4-Br
1143Pr—FEt2-NMe3OTf, 4-
Br
1114Pr—FEt2-NMe3I, 4-Br
1115Pr—FEt2-I, 4-F
1116Pr—FEt2-I, 4-NO2
1117Pr—FEt2-I, 4-NH2
1148Pr—FEt2-I, 4-NHMe
1149Pr—FEt2-I, 4-NMe2
1150Pr—FEt2-I, 4-NMe3OTf
1151Pr—FEt2-I, 4-NMe3I
1152Pr—FEt2-F, 4-I
1153Pr—FEt2-NO2, 4-I
1154Pr—FEt2-NH2, 4-I
1155Pr—FEt2-NHMe, 4-I
1156Pr—FEt2-NMe2, 4-I
1157Pr—FEt2-NMe3OTf, 4-I
1158Pr—FEt2-NMe3I, 4-I
1159Pr—FEt2-Me, 3-F
1160Pr—FEt2-Me, 3-NO2
1161Pr—FEt2-Me, 3-NH2
1162Pr—FEt2-Me, 3-NHMe
1163Pr—FEt2-Me, 3-NMe2
1164Pr—FEt2-Me, 3-
NMe3OTf
1165Pr—FEt2-Me, 3-NMe3I
1166Pr—FEt2-Me, 4-F
1167Pr—FEt2-Me, 4-NO2
1168Pr—FEt2-Me, 4-NH2
1169Pr—FEt2-Me, 4-NHMe
1170Pr—FEt2-Me, 4-NMe2
1171Pr—FEt2-Me, 4-
NMe3OTf
1172Pr—FEt2-Me, 4-NMe3I
1173Pr—FEt2-Me, 5-F
1174Pr—FEt2-Me, 5-NO2
1175Pr—FEt2-Me, 5-NH2
1176Pr—FEt2-Me, 5-NHMe
1177Pr—FEt2-Me, 5-NMe2
1178Pr—FEt2-Me, 5-
NMe3OTf
1179Pr—FEt2-Me, 5-NMe3I
1180Pr—FEt2-F, 4-Me
1181Pr—FEt2-NO2, 4-Me
1182Pr—FEt2-NH2, 4-Me
1183Pr—FEt2-NHMe, 4-Me
1184Pr—FEt2-NMe2, 4-Me
1185Pr—FEt2-NMe3, 4-Me
1186Pr—FEt2-NMe3OTf, 4-
Me
1187Pr—FEt2-NMe3I, 4-Me
1188Pr—FEt2-SnMe3, 4-F
1189Pr—FEt2-SnMe3, 5-F
1190Pr—FEt2-F, 4-SnMe3
1191Pr—FEt2-Br, 6-Cl, 4-F
1192Pr—FEt2-Br, 6-Cl, 4-
NO2
1193Pr—FEt2-Br, 6-Cl, 4-
NH2
1194Pr—FEt2-Br, 6-Cl, 4-
NHMe
1195Pr—FEt2-Br, 6-Cl, 4-
NMe2
1196Pr—FEt2-Br, 6-Cl 4-
NMe3OTf
1197Pr—FEt2-Br, 6-Cl, 4-
NMe3I
1198Pr—FEt2-Me, 6-Cl, 4-F
1199Pr—FEt2-SnMe3, 6-Cl, 4-
F
1200Pr—FEt2-Cl, 4-Me
1201Pr—FEt2-Cl, 4-Br
1202Pr—FEt2-Cl, 4-SnMe3
1203Pr—FEt2-Br, 4-Cl
1204Pr—FEt2-SnMe3, 4-Cl
1205Pr—FEt2-Me, 4-Cl
1206Pr—FEt2-Br, 4-Br
1207Pr—FEt2-Br, 4-Me
1208Pr—FEt2-Br, 4-SnMe3
1209Pr—FEt2-SnMe3, 4-Br
1210Pr—FEt2-Me, 4-Br
1211Pr—FEt2-Me, 4-SnMe3
1212Pr—FEt2-SnMe3, 4-Me
1213Pr—FEt2-Me, 4-Me
1214Pr—FEt2-Et, 4-Br
1215Pr—FEt2-Et, 4-SnMe3
1216Pr—FEt2-Et, 4-Me
1217Pr—FEt2-Me, 4-Me, 6-Me
1218Pr—FEt2-Me, 4-Br, 6-Me
1219Pr—FEt2-Me, 4-SnMe3,
6-Me
1220Pr—FEt2-Et, 6-Me
1221Pr—FEt2-Br, 4-i-Pr
1222Pr—FEt2-SnMe3, 4-i-Pr
1223Pr—FEt2-Me, 4-i-Pr
1224Pr—FEt2-Br, 4-Br, 6-Br
1225Pr—FEt2-Br, 4-Me, 6-Br
1226Pr—FEt2-Br, 4-SnMe3,
6-Br
1227Pr—FEt2-SnMe3, 4-Br,
6-Br
1228Pr—FEt2-Br, 4-Br, 6-Me
1229Pr—FEt2-Br, 4-CF3, 6-Br
1230Pr—FEt2-Br, 4-Br, 6-CF3
1231Pr—FEt2-CF3, 4-CF3
1232Pr—FEt2-Cl, 4-CF3
1233Pr—FEt2-CF3, 4-Cl
1234Pr—FEt2-Br, 4-CF3
1235Pr—FEt2-SnMe3, 4-CF3
1236Pr—FEt2-Me, 4-CF3
1237Pr—FEt2-CF3, 4-Br
1238Pr—FEt2-CF3, 4-SnMe3
1239Pr—FEt2-CF3, 4-Me
1240Pr—FEt2-Br, 4-OH
1241Pr—FEt2-Br, 4-OMe
1242Pr—FEt2-Br, 4-OMeF
1243Pr—FEt2-Br, 4-OCF3
1244Pr—FEt2-Br, 4-OEtF
1245Pr—FEt2-Br, 4-OPrF
1246Pr—FEt2-OH, 4-Br
1247Pr—FEt2-OMe, 4-Br
1248Pr—FEt2-OMeF, 4-Br
1249Pr—FEt2-OCF3, 4-Br
1250Pr—FEt2-OEtF, 4-Br
1251Pr—FEt2-OPrF, 4-Br
1252Pr—FEt2-I, 4-OH
1253Pr—FEt2-I, 4-OMe
1254Pr—FEt2-I, 4-OMeF
1255Pr—FEt2-I, 4-OCF3
1256Pr—FEt2-I, 4-OEtF
1257Pr—FEt2-I, 4-OPrF
1258Pr—FEt2-OH, 4-I
1259Pr—FEt2-OMe, 4-I
1260Pr—FEt2-OMeF, 4-I
1261Pr—FEt2-OCF3, 4-I
1262Pr—FEt2-OEtF, 4-I
1263Pr—FEt2-OPrF, 4-I
1264Pr—FEt2-SnMe3, 4-OH
1265Pr—FEt2-SnMe3, 4-OMe
1266Pr—FEt2-SnMe3, 4-
OMeF
1267Pr—FEt2-SnMe3, 4-OCF3
1268Pr—FEt2-SnMe3, 4-OEtF
1269Pr—FEt2-SnMe3, 4-OPrF
1270Pr—FEt2-OH, 4-SnMe3
1271Pr—FEt2-OMe, 4-SnMe3
1272Pr—FEt2-OMeF, 4-
SnMe3
1273Pr—FEt2-OCF3, 4-SnMe3
1274Pr—FEt2-OEtF, 4-SnMe3
1275Pr—FEt2-OPrF, 4-SnMe3
1276BuEt—FH
1277BuEt—F2-t-Bu
1278BuEt—F2-Br
1279BuEt—F3-Br
1280BuEt—F4-Br
1281BuEt—F2-I
1282BuEt—F3-I
1283BuEt—F4-I
1284BuEt—F2-SnMe3
1285BuEt—F3-SnMe3
1286BuEt—F4-SnMe3
1287BuEt—F2-Me
1288BuEt—F3-Me
1289BuEt—F4-Me
1290BuEt—F2-OH
1291BuEt—F3-OH
1292BuEt—F4-OH
1293BuEt—F2-OMe
1294BuEt—F3-OMe
1295BuEt—F4-OMe
1296BuEt—F2-OMeF
1297BuEt—F3-OMeF
1298BuEt—F4-OMeF
1299BuEt—F2-OCF3
1300BuEt—F3-OCF3
1301BuEt—F4-OCF3
1302BuEt—F2-OEtF
1303BuEt—F3-OEtF
1304BuEt—F4-OEtF
1305BuEt—F2-OPrF
1306BuEt—F3-OPrF
1307BuEt—F4-OPrF
1308BuEt—F2-SH
1309BuEt—F3-SH
1310BuEt—F4-SH
1311BuEt—F2-SMe
1312BuEt—F3-SMe
1313BuEt—F4-SMe
1314BuEt—F2-SMeF
1315BuEt—F3-SMeF
1316BuEt—F4-SMeF
1317BuEt—F2-SCF3
1318BuEt—F3-SCF3
1319BuEt—F4-SCF3
1320BuEt—F2-SEtF
1321BuEt—F3-SEtF
1322BuEt—F4-SEtF
1323BuEt—F2-SPrF
1324BuEt—F3-SPrF
1325BuEt—F4-SPrF
1326BuEt—F2-OMe, 4-OMe
1327BuEt—F2-Me, 5-OH
1328BuEt—F2-Me, 5-OMe
1329BuEt—F2-Me, 5-OMeF
1330BuEt—F2-Me, 5-OEtF
1331BuEt—F2-Me, 5-OPrF
1332BuEt—F2-Me, 4-OH
1333BuEt—F2-Me, 4-OMe
1334BuEt—F2-Me, 4-OMeF
1335BuEt—F2-Me, 4-OCF3
1336BuEt—F2-Me, 4-OEtF
1337BuEt—F2-Me, 4-OPrF
1338BuEt—F2-OH, 4-Me
1339BuEt—F2-OMe, 4-Me
1340BuEt—F2-OMeF, 4-Me
1341BuEt—F2-OCF3, 4-Me
1342BuEt—F2-OEtF, 4-Me
1343BuEt—F2-OPrF, 4-Me
1344BuEt—F2-Cl, 4-OH
1345BuEt—F2-Cl, 4-OMe
1346BuEt—F2-Cl, 4-OMeF
1347BuEt—F2-Cl, 4-OCF3
1348BuEt—F2-Cl, 4-OEtF
1349BuEt—F2-Cl, 4-OPrF
1350BuEt—F2-F, 4-F
1351BuEt—F2-Cl, 4-Cl
1352BuEt—F2-Cl, 4-F
1353BuEt—F2-Cl, 4-NO2
1354BuEt—F2-Cl, 4-NH2
1355BuEt—F2-Cl, 4-NHMe
1356BuEt—F2-Cl, 4-NMe2
1357BuEt—F2-Cl, 4-NMe3OTf
1358BuEt—F2-Cl, 4-NMe3I
1359BuEt—F2-Cl, 5-F
1360BuEt—F2-Cl, 5-NO2
1361BuEt—F2-Cl, 5-NH2
1362BuEt—F2-Cl, 5-NHMe
1363BuEt—F2-Cl, 5-NMe2
1364BuEt—F2-Cl, 5-NMe3OTf
1365BuEt—F2-Cl, 5-NMe3I
1366BuEt—F2-F, 4-Cl
1367BuEt—F2-NO2, 4-Cl
1368BuEt—F2-NH2, 4-Cl
1369BuEt—F2-NHMe, 4-Cl
1370BuEt—F2-NMe2, 4-Cl
1371BuEt—F2-NMe3OTf, 4-Cl
1372BuEt—F2-NMe3I, 4-Cl
1373BuEt—F2-F, 5-Cl
1374BuEt—F2-NO2, 5-Cl
1375BuEt—F2-NH2, 5-Cl
1376BuEt—F2-NHMe, 5-Cl
1377BuEt—F2-NMe2, 5-Cl
1378BuEt—F2-NMe3OTf, 5-Cl
1379BuEt—F2-NMe3I, 5-Cl
1380BuEt—F2-Br, 4-F
1381BuEt—F2-Br, 4-NO2
1382BuEt—F2-Br, 4-NH2
1383BuEt—F2-Br, 4-NHMe
1384BuEt—F2-Br, 4-NMe2
1385BuEt—F2-Br, 4-
NMe3OTf
1386BuEt—F2-Br, 4-NMe3I
1387BuEt—F2-Br, 5-F
1388BuEt—F2-Br, 5-NO2
1389BuEt—F2-Br, 5-NH2
1390BuEt—F2-Br, 5-NHMe
1391BuEt—F2-Br, 5-NMe2
1392BuEt—F2-Br, 5-
NMe3OTf
1393BuEt—F2-Br, 5-NMe3I
1394BuEt—F2-F, 4-Br
1395BuEt—F2-NO2, 4-Br
1396BuEt—F2-NH2, 4-Br
1397BuEt—F2-NHMe, 4-Br
1398BuEt—F2-NMe2, 4-Br
1399BuEt—F2-NMe3OTf, 4-
Br
1400BuEt—F2-NMe3I, 4-Br
1401BuEt—F2-I, 4-F
1402BuEt—F2-I, 4-NO2
1403BuEt—F2-I, 4-NH2
1404BuEt—F2-I, 4-NHMe
1405BuEt—F2-I, 4-NMe2
1406BuEt—F2-I, 4-NMe3OTf
1407BuEt—F2-I, 4-NMe3I
1408BuEt—F2-F, 4-I
1409BuEt—F2-NO2, 4-I
1410BuEt—F2-NH2, 4-I
1411BuEt—F2-NHMe, 4-I
1412BuEt—F2-NMe2, 4-I
1413BuEt—F2-NMe3OTf, 4-I
1414BuEt—F2-NMe3I, 4-I
1415BuEt—F2-Me, 3-F
1416BuEt—F2-Me, 3-NO2
1417BuEt—F2-Me, 3-NH2
1418BuEt—F2-Me, 3-NHMe
1419BuEt—F2-Me, 3-NMe2
1420BuEt—F2-Me, 3-
NMe3OTf
1421BuEt—F2-Me, 3-NMe3I
1422BuEt—F2-Me, 4-F
1423BuEt—F2-Me, 4-NO2
1424BuEt—F2-Me, 4-NH2
1425BuEt—F2-Me, 4-NHMe
1426BuEt—F2-Me, 4-NMe2
1427BuEt—F2-Me, 4-
NMe3OTf
1428BuEt—F2-Me, 4-NMe3I
1429BuEt—F2-Me, 5-F
1430BuEt—F2-Me, 5-NO2
1431BuEt—F2-Me, 5-NH2
1432BuEt—F2-Me, 5-NHMe
1433BuEt—F2-Me, 5-NMe2
1434BuEt—F2-Me, 5-
NMe3OTf
1435BuEt—F2-Me, 5-NMe3I
1436BuEt—F2-F, 4-Me
1437BuEt—F2-NO2, 4-Me
1438BuEt—F2-NH2, 4-Me
1439BuEt—F2-NHMe, 4-Me
1440BuEt—F2-NMe2, 4-Me
1441BuEt—F2-NMe3, 4-Me
1442BuEt—F2-NMe3OTf, 4-
Me
1443BuEt—F2-NMe3I, 4-Me
1444BuEt—F2-SnMe3, 4-F
1445BuEt—F2-SnMe3, 5-F
1446BuEt—F2-F, 4-SnMe3
1447BuEt—F2-Br, 6-Cl, 4-F
1448BuEt—F2-Br, 6-Cl, 4-
NO2
1449BuEt—F2-Br, 6-Cl, 4-
NH2
1450BuEt—F2-Br, 6-Cl, 4-
NHMe
1451BuEt—F2-Br, 6-Cl, 4-
NMe2
1452BuEt—F2-Br, 6-Cl 4-
NMe3OTf
1453BuEt—F2-Br, 6-Cl, 4-
NMe3I
1454BuEt—F2-Me, 6-Cl, 4-F
1455BuEt—F2-SnMe3, 6-Cl, 4-
F
1456BuEt—F2-Cl, 4-Me
1457BuEt—F2-Cl, 4-Br
1458BuEt—F2-Cl, 4-SnMe3
1459BuEt—F2-Br, 4-Cl
1460BuEt—F2-SnMe3, 4-Cl
1461BuEt—F2-Me, 4-Cl
1462BuEt—F2-Br, 4-Br
1463BuEt—F2-Br, 4-Me
1464BuEt—F2-Br, 4-SnMe3
1465BuEt—F2-SnMe3, 4-Br
1466BuEt—F2-Me, 4-Br
1467BuEt—F2-Me, 4-SnMe3
1468BuEt—F2-SnMe3, 4-Me
1469BuEt—F2-Me, 4-Me
1470BuEt—F2-Et, 4-Br
1471BuEt—F2-Et, 4-SnMe3
1472BuEt—F2-Et, 4-Me
1473BuEt—F2-Me, 4-Me, 6-Me
1474BuEt—F2-Me, 4-Br, 6-Me
1475BuEt—F2-Me, 4-SnMe3,
6-Me
1476BuEt—F2-Et, 6-Me
1477BuEt—F2-Br, 4-i-Pr
1478BuEt—F2-SnMe3, 4-i-Pr
1479BuEt—F2-Me, 4-i-Pr
1480BuEt—F2-Br, 4-Br, 6-Br
1481BuEt—F2-Br, 4-Me, 6-Br
1482BuEt—F2-Br, 4-SnMe3,
6-Br
1483BuEt—F2-SnMe3, 4-Br,
6-Br
1484BuEt—F2-Br, 4-Br, 6-Me
1485BuEt—F2-Br, 4-CF3, 6-Br
I486BuEt—F2-Br, 4-Br, 6-CF3
1487BuEt—F2-CF3, 4-CF3
1488BuEt—F2-Cl, 4-CF3
1489BuEt—F2-CF3, 4-Cl
1490BuEt—F2-Br, 4-CF3
1491BuEt—F2-SnMe3, 4-CF3
1492BuEt—F2-Me, 4-CF3
1493BuEt—F2-CF3, 4-Br
1494BuEt—F2-CF3, 4-SnMe3
1495BuEt—F2-CF3, 4-Me
1496BuEt—F2-Br, 4-OH
1497BuEt—F2-Br, 4-OMe
1498BuEt—F2-Br, 4-OMeF
1499BuEt—F2-Br, 4-OCF3
1500BuEt—F2-Br, 4-OEtF
1501BuEt—F2-Br, 4-OPrF
1502BuEt—F2-OH, 4-Br
1503BuEt—F2-OMe, 4-Br
1504BuEt—F2-OMeF, 4-Br
1505BuEt—F2-OCF3, 4-Br
1506BuEt—F2-OEtF, 4-Br
1507BuEt—F2-OPrF, 4-Br
1508BuEt—F2-I, 4-OH
1509BuEt—F2-I, 4-OMe
1510BuEt—F2-I, 4-OMeF
1511BuEt—F2-I, 4-OCF3
1512BuEt—F2-I, 4-OEtF
1513BuEt—F2-I, 4-OPrF
1514BuEt—F2-OH, 4-I
1515BuEt—F2-OMe, 4-I
1516BuEt—F2-OMeF, 4-I
1517BuEt—F2-OCF3, 4-I
1518BuEt—F2-OEtF, 4-I
1519BuEt—F2-OPrF, 4-I
1520BuEt—F2-SnMe3, 4-OH
1521BuEt—F2-SnMe3, 4-OMe
1522BuEt—F2-SnMe3, 4-
OMeF
1523BuEt—F2-SnMe3, 4-OCF3
1524BuEt—F2-SnMe3, 4-OEtF
1525BuEt—F2-SnMe3, 4-OPrF
1526BuEt—F2-OH, 4-SnMe3
1527BuEt—F2-OMe, 4-SnMe3
1528BuEt—F2-OMeF, 4-
SnMe3
1529BuEt—F2-OCF3, 4-SnMe3
1530BuEt—F2-OEtF, 4-SnMe3
1531BuEt—F2-OPrF, 4-SnMe3
1532Bu—FEtH
1533Bu—FEt2-t-Bu
1534Bu—FEt2-Br
1535Bu—FEt3-Br
1536Bu—FEt4-Br
1537Bu—FEt2-I
1538Bu—FEt3-I
1539Bu—FEt4-I
1540Bu—FEt2-SnMe3
1541Bu—FEt3-SnMe3
1542Bu—FEt4-SnMe3
1543Bu—FEt2-Me
1544Bu—FEt3-Me
1545Bu—FEt4-Me
1546Bu—FEt2-OH
1547Bu—FEt3-OH
1548Bu—FEt4-OH
1549Bu—FEt2-OMe
1550Bu—FEt3-OMe
1551Bu—FEt4-OMe
1552Bu—FEt2-OMeF
1553Bu—FEt3-OMeF
1554Bu—FEt4-OMeF
1555Bu—FEt2-OCF3
1556Bu—FEt3-OCF3
1557Bu—FEt4-OCF3
1558Bu—FEt2-OEtF
1559Bu—FEt3-OEtF
1560Bu—FEt4-OEtF
1561Bu—FEt2-OPrF
1562Bu—FEt3-OPrF
1563Bu—FEt4-OPrF
1564Bu—FEt2-SH
1565Bu—FEt3-SH
1566Bu—FEt4-SH
1567Bu—FEt2-SMe
1568Bu—FEt3-SMe
1569Bu—FEt4-SMe
1570Bu—FEt2-SMeF
1571Bu—FEt3-SMeF
1572Bu—FEt4-SMeF
1573Bu—FEt2-SCF3
1574Bu—FEt3-SCF3
1575Bu—FEt4-SCF3
1576Bu—FEt2-SEtF
1577Bu—FEt3-SEtF
1578Bu—FEt4-SEtF
1579Bu—FEt2-SPrF
1580Bu—FEt3-SPrF
1581Bu—FEt4-SPrF
1582Bu—FEt2-OMe, 4-OMe
1583Bu—FEt2-Me, 5-OH
1584Bu—FEt2-Me, 5-OMe
1585Bu—FEt2-Me, 5-OMeF
1586Bu—FEt2-Me, 5-OEtF
1587Bu—FEt2-Me, 5-OPrF
1588Bu—FEt2-Me, 4-OH
1589Bu—FEt2-Me, 4-OMe
1590Bu—FEt2-Me, 4-OMeF
1591Bu—FEt2-Me, 4-OCF3
1592Bu—FEt2-Me, 4-OEtF
1593Bu—FEt2-Me, 4-OPrF
1594Bu—FEt2-OH, 4-Me
1595Bu—FEt2-OMe, 4-Me
1596Bu—FEt2-OMeF, 4-Me
1597Bu—FEt2-OCF3, 4-Me
1598Bu—FEt2-OEtF, 4-Me
1599Bu—FEt2-OPrF, 4-Me
1600Bu—FEt2-Cl, 4-OH
1601Bu—FEt2-Cl, 4-OMe
1602Bu—FEt2-Cl, 4-OMeF
1603Bu—FEt2-Cl, 4-OCF3
1604Bu—FEt2-Cl, 4-OEtF
1605Bu—FEt2-Cl, 4-OPrF
1606Bu—FEt2-F, 4-F
1607Bu—FEt2-Cl, 4-Cl
1608Bu—FEt2-Cl, 4-F
1609Bu—FEt2-Cl, 4-NO2
1610Bu—FEt2-Cl, 4-NH2
1611Bu—FEt2-Cl, 4-NHMe
1612Bu—FEt2-Cl, 4-NMe2
1613Bu—FEt2-Cl, 4-NMe3OTf
1614Bu—FEt2-Cl, 4-NMe3I
1615Bu—FEt2-Cl, 5-F
1616Bu—FEt2-Cl, 5-NO2
1617Bu—FEt2-Cl, 5-NH2
1618Bu—FEt2-Cl, 5-NHMe
1619Bu—FEt2-Cl, 5-NMe2
1620Bu—FEt2-Cl, 5-NMe3OTf
1621Bu—FEt2-Cl, 5-NMe3I
1622Bu—FEt2-F, 4-Cl
1623Bu—FEt2-NO2, 4-Cl
1624Bu—FEt2-NH2, 4-Cl
1625Bu—FEt2-NHMe, 4-Cl
1626Bu—FEt2-NMe2, 4-Cl
1627Bu—FEt2-NMe3OTf, 4-Cl
1628Bu—FEt2-NMe3I, 4-Cl
1629Bu—FEt2-F, 5-Cl
1630Bu—FEt2-NO2, 5-Cl
1631Bu—FEt2-NH2, 5-Cl
1632Bu—FEt2-NHMe, 5-Cl
1633Bu—FEt2-NMe2, 5-Cl
1634Bu—FEt2-NMe3OTf, 5-Cl
1635Bu—FEt2-NMe3I, 5-Cl
1636Bu—FEt2-Br, 4-F
1637Bu—FEt2-Br, 4-NO2
1638Bu—FEt2-Br, 4-NH2
1639Bu—FEt2-Br, 4-NHMe
1640Bu—FEt2-Br, 4-NMe2
1641Bu—FEt2-Br, 4-
NMe3OTf
1642Bu—FEt2-Br, 4-NMe3I
1643Bu—FEt2-Br, 5-F
1644Bu—FEt2-Br, 5-NO2
1645Bu—FEt2-Br, 5-NH2
1646Bu—FEt2-Br, 5-NHMe
1647Bu—FEt2-Br, 5-NMe2
1648Bu—FEt2-Br, 5-
NMe3OTf
1649Bu—FEt2-Br, 5-NMe3I
1650Bu—FEt2-F, 4-Br
1651Bu—FEt2-NO2, 4-Br
1652Bu—FEt2-NH2, 4-Br
1653Bu—FEt2-NHMe, 4-Br
1654Bu—FEt2-NMe2, 4-Br
1655Bu—FEt2-NMe3OTf, 4-
Br
1656Bu—FEt2-NMe3I, 4-Br
1657Bu—FEt2-I, 4-F
1658Bu—FEt2-I, 4-NO2
1659Bu—FEt2-I, 4-NH2
1660Bu—FEt2-I, 4-NHMe
1661Bu—FEt2-I, 4-NMe2
1662Bu—FEt2-I, 4-NMe3OTf
1663Bu—FEt2-I, 4-NMe3I
1664Bu—FEt2-F, 4-I
1665Bu—FEt2-NO2, 4-I
1666Bu—FEt2-NH2, 4-I
1667Bu—FEt2-NHMe, 4-I
1668Bu—FEt2-NMe2, 4-I
1669Bu—FEt2-NMe3OTf, 4-I
1670Bu—FEt2-NMe3I, 4-I
1671Bu—FEt2-Me, 3-F
1672Bu—FEt2-Me, 3-NO2
1673Bu—FEt2-Me, 3-NH2
1674Bu—FEt2-Me, 3-NHMe
1675Bu—FEt2-Me, 3-NMe2
1676Bu—FEt2-Me, 3-
NMe3OTf
1677Bu—FEt2-Me, 3-NMe3I
1678Bu—FEt2-Me, 4-F
1679Bu—FEt2-Me, 4-NO2
1680Bu—FEt2-Me, 4-NH2
1681Bu—FEt2-Me, 4-NHMe
1682Bu—FEt2-Me, 4-NMe2
1683Bu—FEt2-Me, 4-
NMe3OTf
1684Bu—FEt2-Me, 4-NMe3I
1685Bu—FEt2-Me, 5-F
1686Bu—FEt2-Me, 5-NO2
1687Bu—FEt2-Me, 5-NH2
1688Bu—FEt2-Me, 5-NHMe
1689Bu—FEt2-Me, 5-NMe2
1690Bu—FEt2-Me, 5-
NMe3OTf
1691Bu—FEt2-Me, 5-NMe3I
1692Bu—FEt2-F, 4-Me
1693Bu—FEt2-NO2, 4-Me
1694Bu—FEt2-NH2, 4-Me
1695Bu—FEt2-NHMe, 4-Me
1696Bu—FEt2-NMe2, 4-Me
1697Bu—FEt2-NMe3, 4-Me
1698Bu—FEt2-NMe3OTf, 4-
Me
1699Bu—FEt2-NMe3I, 4-Me
1700Bu—FEt2-SnMe3, 4-F
1701Bu—FEt2-SnMe3, 5-F
1702Bu—FEt2-F, 4-SnMe3
1703Bu—FEt2-Br, 6-Cl, 4-F
1704Bu—FEt2-Br, 6-Cl, 4-
NO2
1705Bu—FEt2-Br, 6-Cl, 4-
NH2
1706Bu—FEt2-Br, 6-Cl, 4-
NHMe
1707Bu—FEt2-Br, 6-Cl, 4-
NMe2
1708Bu—FEt2-Br, 6-Cl 4-
NMe3OTf
1709Bu—FEt2-Br, 6-Cl, 4-
NMe3I
1710Bu—FEt2-Me, 6-Cl, 4-F
1711Bu—FEt2-SnMe3, 6-Cl, 4-
F
1712Bu—FEt2-Cl, 4-Me
1713Bu—FEt2-Cl, 4-Br
1714Bu—FEt2-Cl, 4-SnMe3
1715Bu—FEt2-Br, 4-Cl
1716Bu—FEt2-SnMe3, 4-Cl
1717Bu—FEt2-Me, 4-Cl
1718Bu—FEt2-Br, 4-Br
1719Bu—FEt2-Br, 4-Me
1720Bu—FEt2-Br, 4-SnMe3
1721Bu—FEt2-SnMe3, 4-Br
1722Bu—FEt2-Me, 4-Br
1723Bu—FEt2-Me, 4-SnMe3
1724Bu—FEt2-SnMe3, 4-Me
1725Bu—FEt2-Me, 4-Me
1726Bu—FEt2-Et, 4-Br
1727Bu—FEt2-Et, 4-SnMe3
1728Bu—FEt2-Et, 4-Me
1729Bu—FEt2-Me, 4-Me, 6-Me
1730Bu—FEt2-Me, 4-Br, 6-Me
1731Bu—FEt2-Me, 4-SnMe3,
6-Me
1732Bu—FEt2-Et, 6-Me
1733Bu—FEt2-Br, 4-i-Pr
1734Bu—FEt2-SnMe3, 4-i-Pr
1735Bu—FEt2-Me, 4-i-Pr
1736Bu—FEt2-Br, 4-Br, 6-Br
1737Bu—FEt2-Br, 4-Me, 6-Br
1738Bu—FEt2-Br, 4-SnMe3,
6-Br
1739Bu—FEt2-SnMe3, 4-Br,
6-Br
1740Bu—FEt2-Br, 4-Br, 6-Me
1741Bu—FEt2-Br, 4-CF3, 6-Br
1742Bu—FEt2-Br, 4-Br, 6-CF3
1743Bu—FEt2-CF3, 4-CF3
1744Bu—FEt2-Cl, 4-CF3
1745Bu—FEt2-CF3, 4-Cl
1746Bu—FEt2-Br, 4-CF3
1747Bu—FEt2-SnMe3, 4-CF3
1748Bu—FEt2-Me, 4-CF3
1749Bu—FEt2-CF3, 4-Br
1750Bu—FEt2-CF3, 4-SnMe3
1751Bu—FEt2-CF3, 4-Me
1752Bu—FEt2-Br, 4-OH
1753Bu—FEt2-Br, 4-OMe
1754Bu—FEt2-Br, 4-OMeF
1755Bu—FEt2-Br, 4-OCF3
1756Bu—FEt2-Br, 4-OEtF
1757Bu—FEt2-Br, 4-OPrF
1758Bu—FEt2-OH, 4-Br
1759Bu—FEt2-OMe, 4-Br
1760Bu—FEt2-OMeF, 4-Br
1761Bu—FEt2-OCF3, 4-Br
1762Bu—FEt2-OEtF, 4-Br
1763Bu—FEt2-OPrF, 4-Br
1764Bu—FEt2-I, 4-OH
1765Bu—FEt2-I, 4-OMe
1766Bu—FEt2-I, 4-OMeF
1767Bu—FEt2-I, 4-OCF3
1768Bu—FEt2-I, 4-OEtF
1769Bu—FEt2-I, 4-OPrF
1770Bu—FEt2-OH, 4-I
1771Bu—FEt2-OMe, 4-I
1772Bu—FEt2-OMeF, 4-I
1773Bu—FEt2-OCF3, 4-I
1774Bu—FEt2-OEtF, 4-I
1775Bu—FEt2-OPrF, 4-I
1776Bu—FEt2-SnMe3, 4-OH
1777Bu—FEt2-SnMe3, 4-OMe
1778Bu—FEt2-SnMe3, 4-
OMeF
1779Bu—FEt2-SnMe3, 4-OCF3
1780Bu—FEt2-SnMe3, 4-OEtF
1781Bu—FEt2-SnMe3, 4-OPrF
1782Bu—FEt2-OH, 4-SnMe3
1783Bu—FEt2-OMe, 4-SnMe3
1784Bu—FEt2-OMeF, 4-
SnMe3
I785Bu—FEt2-OCF3, 4-SnMe3
1786Bu—FEt2-OEtF, 4-SnMe3
1787Bu—FEt2-OPrF, 4-SnMe3
1788FCH2—CH═CH—CH2MeH
1789FCH2—CH═CH—CH2Me2-t-Bu
1790FCH2—CH═CH—CH2Me2-Br
1791FCH2—CH═CH—CH2Me3-Br
1792FCH2—CH═CH—CH2Me4-Br
1793FCH2—CH═CH—CH2Me2-I
1794FCH2—CH═CH—CH2Me3-I
1795FCH2—CH═CH—CH2Me4-I
1796FCH2—CH═CH—CH2Me2-SnMe3
1797FCH2—CH═CH—CH2Me3-SnMe3
1798FCH2—CH═CH—CH2Me4-SnMe3
1799FCH2—CH═CH—CH2Me2-Me
1800FCH2—CH═CH—CH2Me3-Me
1801FCH2—CH═CH—CH2Me4-Me
1802FCH2—CH═CH—CH2Me2-OH
1803FCH2—CH═CH—CH2Me3-OH
1804FCH2—CH═CH—CH2Me4-OH
1805FCH2—CH═CH—CH2Me2-OMe
1806FCH2—CH═CH—CH2Me3-OMe
1807FCH2—CH═CH—CH2Me4-OMe
1808FCH2—CH═CH—CH2Me2-OMeF
1809FCH2—CH═CH—CH2Me3-OMeF
1810FCH2—CH═CH—CH2Me4-OMeF
1811FCH2—CH═CH—CH2Me2-OCF3
1812FCH2—CH═CH—CH2Me3-OCF3
1813FCH2—CH═CH—CH2Me4-OCF3
1814FCH2—CH═CH—CH2Me2-OEtF
1815FCH2—CH═CH—CH2Me3-OEtF
1816FCH2—CH═CH—CH2Me4-OEtF
1817FCH2—CH═CH—CH2Me2-OPrF
1818FCH2—CH═CH—CH2Me3-OPrF
1819FCH2—CH═CH—CH2Me4-OPrF
1820FCH2—CH═CH—CH2Me2-SH
1821FCH2—CH═CH—CH2Me3-SH
1822FCH2—CH═CH—CH2Me4-SH
1823FCH2—CH═CH—CH2Me2-SMe
1824FCH2—CH═CH—CH2Me3-SMe
1825FCH2—CH═CH—CH2Me4-SMe
1826FCH2—CH═CH—CH2Me2-SMeF
1827FCH2—CH═CH—CH2Me3-SMeF
1828FCH2—CH═CH—CH2Me4-SMeF
1829FCH2—CH═CH—CH2Me2-SCF3
1830FCH2—CH═CH—CH2Me3-SCF3
1831FCH2—CH═CH—CH2Me4-SCF3
1832FCH2—CH═CH—CH2Me2-SEtF
1833FCH2—CH═CH—CH2Me3-SEtF
1834FCH2—CH═CH—CH2Me4-SEtF
1835FCH2—CH═CH—CH2Me2-SPrF
1836FCH2—CH═CH—CH2Me3-SPrF
1837FCH2—CH═CH—CH2Me4-SPrF
1838FCH2—CH═CH—CH2Me2-OMe, 4-OMe
1839FCH2—CH═CH—CH2Me2-Me, 5-OH
1840FCH2—CH═CH—CH2Me2-Me, 5-OMe
1841FCH2—CH═CH—CH2Me2-Me, 5-OMeF
1842FCH2—CH═CH—CH2Me2-Me, 5-OEtF
1843FCH2—CH═CH—CH2Me2-Me, 5-OPrF
1844FCH2—CH═CH—CH2Me2-Me, 4-OH
1845FCH2—CH═CH—CH2Me2-Me, 4-OMe
1846FCH2—CH═CH—CH2Me2-Me, 4-OMeF
1847FCH2—CH═CH—CH2Me2-Me, 4-OCF3
1848FCH2—CH═CH—CH2Me2-Me, 4-OEtF
1849FCH2—CH═CH—CH2Me2-Me, 4-OPrF
1850FCH2—CH═CH—CH2Me2-OH, 4-Me
1851FCH2—CH═CH—CH2Me2-OMe, 4-Me
1852FCH2—CH═CH—CH2Me2-OMeF, 4-Me
1853FCH2—CH═CH—CH2Me2-OCF3, 4-Me
1854FCH2—CH═CH—CH2Me2-OEtF, 4-Me
1855FCH2—CH═CH—CH2Me2-OPrF, 4-Me
1856FCH2—CH═CH—CH2Me2-Cl, 4-OH
1857FCH2—CH═CH—CH2Me2-Cl, 4-OMe
1858FCH2—CH═CH—CH2Me2-Cl, 4-OMeF
1859FCH2—CH═CH—CH2Me2-Cl, 4-OCF3
1860FCH2—CH═CH—CH2Me2-Cl, 4-OEtF
1861FCH2—CH═CH—CH2Me2-Cl, 4-OPrF
1862FCH2—CH═CH—CH2Me2-F, 4-F
1863FCH2—CH═CH—CH2Me2-Cl, 4-Cl
1864FCH2—CH═CH—CH2Me2-Cl, 4-F
1865FCH2—CH═CH—CH2Me2-Cl, 4-NO2
1866FCH2—CH═CH—CH2Me2-Cl, 4-NH2
1867FCH2—CH═CH—CH2Me2-Cl, 4-NHMe
1868FCH2—CH═CH—CH2Me2-Cl, 4-NMe2
1869FCH2—CH═CH—CH2Me2-Cl, 4-NMe3OTf
1870FCH2—CH═CH—CH2Me2-Cl, 4-NMe3I
1871FCH2—CH═CH—CH2Me2-Cl, 5-F
1872FCH2—CH═CH—CH2Me2-Cl, 5-NO2
1873FCH2—CH═CH—CH2Me2-Cl, 5-NH2
1874FCH2—CH═CH—CH2Me2-Cl, 5-NHMe
1875FCH2—CH═CH—CH2Me2-Cl, 5-NMe2
1876FCH2—CH═CH—CH2Me2-Cl, 5-NMe3OTf
1877FCH2—CH═CH—CH2Me2-Cl, 5-NMe3I
1878FCH2—CH═CH—CH2Me2-F, 4-Cl
1879FCH2—CH═CH—CH2Me2-NO2, 4-Cl
1880FCH2—CH═CH—CH2Me2-NH2, 4-Cl
1881FCH2—CH═CH—CH2Me2-NHMe, 4-Cl
1882FCH2—CH═CH—CH2Me2-NMe2, 4-Cl
1883FCH2—CH═CH—CH2Me2-NMe3OTf, 4-Cl
1884FCH2—CH═CH—CH2Me2-NMe3I, 4-Cl
1885FCH2—CH═CH—CH2Me2-F, 5-Cl
1886FCH2—CH═CH—CH2Me2-NO2, 5-Cl
1887FCH2—CH═CH—CH2Me2-NH2, 5-Cl
1888FCH2—CH═CH—CH2Me2-NHMe, 5-Cl
1889FCH2—CH═CH—CH2Me2-NMe2, 5-Cl
1890FCH2—CH═CH—CH2Me2-NMe3OTf, 5-Cl
1891FCH2—CH═CH—CH2Me2-NMe3I, 5-Cl
1892FCH2—CH═CH—CH2Me2-Br, 4-F
1893FCH2—CH═CH—CH2Me2-Br, 4-NO2
1894FCH2—CH═CH—CH2Me2-Br, 4-NH2
1895FCH2—CH═CH—CH2Me2-Br, 4-NHMe
1896FCH2—CH═CH—CH2Me2-Br, 4-NMe2
1897FCH2—CH═CH—CH2Me2-Br, 4-
NMe3OTf
1898FCH2—CH═CH—CH2Me2-Br, 4-NMe3I
1899FCH2—CH═CH—CH2Me2-Br, 5-F
1900FCH2—CH═CH—CH2Me2-Br, 5-NO2
1901FCH2—CH═CH—CH2Me2-Br, 5-NH2
1902FCH2—CH═CH—CH2Me2-Br, 5-NHMe
1903FCH2—CH═CH—CH2Me2-Br, 5-NMe2
1904FCH2—CH═CH—CH2Me2-Br, 5-
NMe3OTf
1905FCH2—CH═CH—CH2Me2-Br, 5-NMe3I
1906FCH2—CH═CH—CH2Me2-F, 4-Br
1907FCH2—CH═CH—CH2Me2-NO2, 4-Br
1908FCH2—CH═CH—CH2Me2-NH2, 4-Br
1909FCH2—CH═CH—CH2Me2-NHMe, 4-Br
1910FCH2—CH═CH—CH2Me2-NMe2, 4-Br
1911FCH2—CH═CH—CH2Me2-NMe3OTf, 4-
Br
1912FCH2—CH═CH—CH2Me2-NMe3I, 4-Br
1913FCH2—CH═CH—CH2Me2-I, 4-F
1914FCH2—CH═CH—CH2Me2-I, 4-NO2
1915FCH2—CH═CH—CH2Me2-I, 4-NH2
1916FCH2—CH═CH—CH2Me2-I, 4-NHMe
1917FCH2—CH═CH—CH2Me2-I, 4-NMe2
1918FCH2—CH═CH—CH2Me2-I, 4-NMe3OTf
1919FCH2—CH═CH—CH2Me2-I, 4-NMe3I
1920FCH2—CH═CH—CH2Me2-F, 4-I
1921FCH2—CH═CH—CH2Me2-NO2, 4-I
1922FCH2—CH═CH—CH2Me2-NH2, 4-I
1923FCH2—CH═CH—CH2Me2-NHMe, 4-I
1924FCH2—CH═CH—CH2Me2-NMe2, 4-I
1925FCH2—CH═CH—CH2Me2-NMe3OTf, 4-I
1926FCH2—CH═CH—CH2Me2-NMe3I, 4-I
1927FCH2—CH═CH—CH2Me2-Me, 3-F
1928FCH2—CH═CH—CH2Me2-Me, 3-NO2
1929FCH2—CH═CH—CH2Me2-Me, 3-NH2
1930FCH2—CH═CH—CH2Me2-Me, 3-NHMe
1931FCH2—CH═CH—CH2Me2-Me, 3-NMe2
1932FCH2—CH═CH—CH2Me2-Me, 3-
NMe3OTf
1933FCH2—CH═CH—CH2Me2-Me, 3-NMe3I
1934FCH2—CH═CH—CH2Me2-Me, 4-F
1935FCH2—CH═CH—CH2Me2-Me, 4-NO2
1936FCH2—CH═CH—CH2Me2-Me, 4-NH2
1937FCH2—CH═CH—CH2Me2-Me, 4-NHMe
1938FCH2—CH═CH—CH2Me2-Me, 4-NMe2
1939FCH2—CH═CH—CH2Me2-Me, 4-
NMe3OTf
1940FCH2—CH═CH—CH2Me2-Me, 4-NMe3I
1941FCH2—CH═CH—CH2Me2-Me, 5-F
1942FCH2—CH═CH—CH2Me2-Me, 5-NO2
1943FCH2—CH═CH—CH2Me2-Me, 5-NH2
1944FCH2—CH═CH—CH2Me2-Me, 5-NHMe
1945FCH2—CH═CH—CH2Me2-Me, 5-NMe2
1946FCH2—CH═CH—CH2Me2-Me, 5-
NMe3OTf
1947FCH2—CH═CH—CH2Me2-Me, 5-NMe3I
1948FCH2—CH═CH—CH2Me2-F, 4-Me
1949FCH2—CH═CH—CH2Me2-NO2, 4-Me
1950FCH2—CH═CH—CH2Me2-NH2, 4-Me
1951FCH2—CH═CH—CH2Me2-NHMe, 4-Me
1952FCH2—CH═CH—CH2Me2-NMe2, 4-Me
1953FCH2—CH═CH—CH2Me2-NMe3, 4-Me
1954FCH2—CH═CH—CH2Me2-NMe3OTf, 4-
Me
1955FCH2—CH═CH—CH2Me2-NMe3I, 4-Me
1956FCH2—CH═CH—CH2Me2-SnMe3, 4-F
1957FCH2—CH═CH—CH2Me2-SnMe3, 5-F
1958FCH2—CH═CH—CH2Me2-F, 4-SnMe3
1959FCH2—CH═CH—CH2Me2-Br, 6-Cl, 4-F
1960FCH2—CH═CH—CH2Me2-Br, 6-Cl, 4-
NO2
1961FCH2—CH═CH—CH2Me2-Br, 6-Cl, 4-
NH2
1962FCH2—CH═CH—CH2Me2-Br, 6-Cl, 4-
NHMe
1963FCH2—CH═CH—CH2Me2-Br, 6-Cl, 4-
NMe2
1964FCH2—CH═CH—CH2Me2-Br, 6-Cl 4-
NMe3OTf
1965FCH2—CH═CH—CH2Me2-Br, 6-Cl, 4-
NMe3I
1966FCH2—CH═CH—CH2Me2-Me, 6-Cl, 4-F
1967FCH2—CH═CH—CH2Me2-SnMe3, 6-Cl, 4-
F
1968FCH2—CH═CH—CH2Me2-Cl, 4-Me
1969FCH2—CH═CH—CH2Me2-Cl, 4-Br
1970FCH2—CH═CH—CH2Me2-Cl, 4-SnMe3
1971FCH2—CH═CH—CH2Me2-Br, 4-Cl
1972FCH2—CH═CH—CH2Me2-SnMe3, 4-Cl
1973FCH2—CH═CH—CH2Me2-Me, 4-Cl
1974FCH2—CH═CH—CH2Me2-Br, 4-Br
1975FCH2—CH═CH—CH2Me2-Br, 4-Me
1976FCH2—CH═CH—CH2Me2-Br, 4-SnMe3
1977FCH2—CH═CH—CH2Me2-SnMe3, 4-Br
1978FCH2—CH═CH—CH2Me2-Me, 4-Br
1979FCH2—CH═CH—CH2Me2-Me, 4-SnMe3
1980FCH2—CH═CH—CH2Me2-SnMe3, 4-Me
1981FCH2—CH═CH—CH2Me2-Me, 4-Me
1982FCH2—CH═CH—CH2Me2-Et, 4-Br
1983FCH2—CH═CH—CH2Me2-Et, 4-SnMe3
1984FCH2—CH═CH—CH2Me2-Et, 4-Me
1985FCH2—CH═CH—CH2Me2-Me, 4-Me, 6-Me
1986FCH2—CH═CH—CH2Me2-Me, 4-Br, 6-Me
1987FCH2—CH═CH—CH2Me2-Me, 4-SnMe3,
6-Me
1988FCH2—CH═CH—CH2Me2-Et, 6-Me
1989FCH2—CH═CH—CH2Me2-Br, 4-i-Pr
1990FCH2—CH═CH—CH2Me2-SnMe3, 4-i-Pr
1991FCH2—CH═CH—CH2Me2-Me, 4-i-Pr
1992FCH2—CH═CH—CH2Me2-Br, 4-Br, 6-Br
1993FCH2—CH═CH—CH2Me2-Br, 4-Me, 6-Br
1994FCH2—CH═CH—CH2Me2-Br, 4-SnMe3,
6-Br
1995FCH2—CH═CH—CH2Me2-SnMe3, 4-Br,
6-Br
1996FCH2—CH═CH—CH2Me2-Br, 4-Br, 6-Me
1997FCH2—CH═CH—CH2Me2-Br, 4-CF3, 6-Br
1998FCH2—CH═CH—CH2Me2-Br, 4-Br, 6-CF3
1999FCH2—CH═CH—CH2Me2-CF3, 4-CF3
2000FCH2—CH═CH—CH2Me2-Cl, 4-CF3
2001FCH2—CH═CH—CH2Me2-CF3, 4-Cl
2002FCH2—CH═CH—CH2Me2-Br, 4-CF3
2003FCH2—CH═CH—CH2Me2-SnMe3, 4-CF3
2004FCH2—CH═CH—CH2Me2-Me, 4-CF3
2005FCH2—CH═CH—CH2Me2-CF3, 4-Br
2006FCH2—CH═CH—CH2Me2-CF3, 4-SnMe3
2007FCH2—CH═CH—CH2Me2-CF3, 4-Me
2008FCH2—CH═CH—CH2Me2-Br, 4-OH
2009FCH2—CH═CH—CH2Me2-Br, 4-OMe
2010FCH2—CH═CH—CH2Me2-Br, 4-OMeF
2011FCH2—CH═CH—CH2Me2-Br, 4-OCF3
2012FCH2—CH═CH—CH2Me2-Br, 4-OEtF
2013FCH2—CH═CH—CH2Me2-Br, 4-OPrF
2014FCH2—CH═CH—CH2Me2-OH, 4-Br
2015FCH2—CH═CH—CH2Me2-OMe, 4-Br
2016FCH2—CH═CH—CH2Me2-OMeF, 4-Br
2017FCH2—CH═CH—CH2Me2-OCF3, 4-Br
2018FCH2—CH═CH—CH2Me2-OEtF, 4-Br
2019FCH2—CH═CH—CH2Me2-OPrF, 4-Br
2020FCH2—CH═CH—CH2Me2-I, 4-OH
2021FCH2—CH═CH—CH2Me2-I, 4-OMe
2022FCH2—CH═CH—CH2Me2-I, 4-OMeF
2023FCH2—CH═CH—CH2Me2-I, 4-OCF3
2024FCH2—CH═CH—CH2Me2-I, 4-OEtF
2025FCH2—CH═CH—CH2Me2-I, 4-OPrF
2026FCH2—CH═CH—CH2Me2-OH, 4-I
2027FCH2—CH═CH—CH2Me2-OMe, 4-I
2028FCH2—CH═CH—CH2Me2-OMeF, 4-I
2029FCH2—CH═CH—CH2Me2-OCF3, 4-I
2030FCH2—CH═CH—CH2Me2-OEtF, 4-I
2031FCH2—CH═CH—CH2Me2-OPrF, 4-I
2032FCH2—CH═CH—CH2Me2-SnMe3, 4-OH
2033FCH2—CH═CH—CH2Me2-SnMe3, 4-OMe
2034FCH2—CH═CH—CH2Me2-SnMe3, 4-
OMeF
2035FCH2—CH═CH—CH2Me2-SnMe3, 4-OCF3
2036FCH2—CH═CH—CH2Me2-SnMe3, 4-OEtF
2037FCH2—CH═CH—CH2Me2-SnMe3, 4-OPrF
2038FCH2—CH═CH—CH2Me2-OH, 4-SnMe3
2039FCH2—CH═CH—CH2Me2-OMe, 4-SnMe3
2040FCH2—CH═CH—CH2Me2-OMeF, 4-
SnMe3
2041FCH2—CH═CH—CH2Me2-OCF3, 4-SnMe3
2042FCH2—CH═CH—CH2Me2-OEtF, 4-SnMe3
2043FCH2—CH═CH—CH2Me2-OPrF, 4-SnMe3
2044FCH2—CH═CH—CH2EtH
2045FCH2—CH═CH—CH2Et2-t-Bu
2046FCH2—CH═CH—CH2Et2-Br
2047FCH2—CH═CH—CH2Et3-Br
2048FCH2—CH═CH—CH2Et4-Br
2049FCH2—CH═CH—CH2Et2-I
2050FCH2—CH═CH—CH2Et3-I
2051FCH2—CH═CH—CH2Et4-I
2052FCH2—CH═CH—CH2Et2-SnMe3
2053FCH2—CH═CH—CH2Et3-SnMe3
2054FCH2—CH═CH—CH2Et4-SnMe3
2055FCH2—CH═CH—CH2Et2-Me
2056FCH2—CH═CH—CH2Et3-Me
2057FCH2—CH═CH—CH2Et4-Me
2058FCH2—CH═CH—CH2Et2-OH
2059FCH2—CH═CH—CH2Et3-OH
2060FCH2—CH═CH—CH2Et4-OH
2061FCH2—CH═CH—CH2Et2-OMe
2062FCH2—CH═CH—CH2Et3-OMe
2063FCH2—CH═CH—CH2Et4-OMe
2064FCH2—CH═CH—CH2Et2-OMeF
2065FCH2—CH═CH—CH2Et3-OMeF
2066FCH2—CH═CH—CH2Et4-OMeF
2067FCH2—CH═CH—CH2Et2-OCF3
2068FCH2—CH═CH—CH2Et3-OCF3
2069FCH2—CH═CH—CH2Et4-OCF3
2070FCH2—CH═CH—CH2Et2-OEtF
2071FCH2—CH═CH—CH2Et3-OEtF
2072FCH2—CH═CH—CH2Et4-OEtF
2073FCH2—CH═CH—CH2Et2-OPrF
2074FCH2—CH═CH—CH2Et3-OPrF
2075FCH2—CH═CH—CH2Et4-OPrF
2076FCH2—CH═CH—CH2Et2-SH
2077FCH2—CH═CH—CH2Et3-SH
2078FCH2—CH═CH—CH2Et4-SH
2079FCH2—CH═CH—CH2Et2-SMe
2080FCH2—CH═CH—CH2Et3-SMe
2081FCH2—CH═CH—CH2Et4-SMe
2082FCH2—CH═CH—CH2Et2-SMeF
2083FCH2—CH═CH—CH2Et3-SMeF
2084FCH2—CH═CH—CH2Et4-SMeF
2085FCH2—CH═CH—CH2Et2-SCF3
2086FCH2—CH═CH—CH2Et3-SCF3
2087FCH2—CH═CH—CH2Et4-SCF3
2088FCH2—CH═CH—CH2Et2-SEtF
2089FCH2—CH═CH—CH2Et3-SEtF
2090FCH2—CH═CH—CH2Et4-SEtF
2091FCH2—CH═CH—CH2Et2-SPrF
2092FCH2—CH═CH—CH2Et3-SPrF
2093FCH2—CH═CH—CH2Et4-SPrF
2094FCH2—CH═CH—CH2Et2-OMe, 4-OMe
2095FCH2—CH═CH—CH2Et2-Me, 5-OH
2096FCH2—CH═CH—CH2Et2-Me, 5-OMe
2097FCH2—CH═CH—CH2Et2-Me, 5-OMeF
2098FCH2—CH═CH—CH2Et2-Me, 5-OEtF
2099FCH2—CH═CH—CH2Et2-Me, 5-OPrF
2100FCH2—CH═CH—CH2Et2-Me, 4-OH
2101FCH2—CH═CH—CH2Et2-Me, 4-OMe
2102FCH2—CH═CH—CH2Et2-Me, 4-OMeF
2103FCH2—CH═CH—CH2Et2-Me, 4-OCF3
2104FCH2—CH═CH—CH2Et2-Me, 4-OEtF
2105FCH2—CH═CH—CH2Et2-Me, 4-OPrF
2106FCH2—CH═CH—CH2Et2-OH, 4-Me
2107FCH2—CH═CH—CH2Et2-OMe, 4-Me
2108FCH2—CH═CH—CH2Et2-OMeF, 4-Me
2109FCH2—CH═CH—CH2Et2-OCF3, 4-Me
2110FCH2—CH═CH—CH2Et2-OEtF, 4-Me
2111FCH2—CH═CH—CH2Et2-OPrF, 4-Me
2112FCH2—CH═CH—CH2Et2-Cl, 4-OH
2113FCH2—CH═CH—CH2Et2-Cl, 4-OMe
2114FCH2—CH═CH—CH2Et2-Cl, 4-OMeF
2115FCH2—CH═CH—CH2Et2-Cl, 4-OCF3
2116FCH2—CH═CH—CH2Et2-Cl, 4-OEtF
2117FCH2—CH═CH—CH2Et2-Cl, 4-OPrF
2118FCH2—CH═CH—CH2Et2-F, 4-F
2119FCH2—CH═CH—CH2Et2-Cl, 4-Cl
2120FCH2—CH═CH—CH2Et2-Cl, 4-F
2121FCH2—CH═CH—CH2Et2-Cl, 4-NO2
2122FCH2—CH═CH—CH2Et2-Cl, 4-NH2
2123FCH2—CH═CH—CH2Et2-Cl, 4-NHMe
2124FCH2—CH═CH—CH2Et2-Cl, 4-NMe2
2125FCH2—CH═CH—CH2Et2-Cl, 4-NMe3OTf
2126FCH2—CH═CH—CH2Et2-Cl, 4-NMe3I
2127FCH2—CH═CH—CH2Et2-Cl, 5-F
2128FCH2—CH═CH—CH2Et2-Cl, 5-NO2
2129FCH2—CH═CH—CH2Et2-Cl, 5-NH2
2130FCH2—CH═CH—CH2Et2-Cl, 5-NHMe
2131FCH2—CH═CH—CH2Et2-Cl, 5-NMe2
2132FCH2—CH═CH—CH2Et2-Cl, 5-NMe3OTf
2133FCH2—CH═CH—CH2Et2-Cl, 5-NMe3I
2134FCH2—CH═CH—CH2Et2-F, 4-Cl
2135FCH2—CH═CH—CH2Et2-NO2, 4-Cl
2136FCH2—CH═CH—CH2Et2-NH2, 4-Cl
2137FCH2—CH═CH—CH2Et2-NHMe, 4-Cl
2138FCH2—CH═CH—CH2Et2-NMe2, 4-Cl
2139FCH2—CH═CH—CH2Et2-NMe3OTf, 4-Cl
2140FCH2—CH═CH—CH2Et2-NMe3I, 4-Cl
2141FCH2—CH═CH—CH2Et2-F, 5-Cl
2142FCH2—CH═CH—CH2Et2-NO2, 5-Cl
2143FCH2—CH═CH—CH2Et2-NH2, 5-Cl
2144FCH2—CH═CH—CH2Et2-NHMe, 5-Cl
2145FCH2—CH═CH—CH2Et2-NMe2, 5-Cl
2146FCH2—CH═CH—CH2Et2-NMe3OTf, 5-Cl
2147FCH2—CH═CH—CH2Et2-NMe3I, 5-Cl
2148FCH2—CH═CH—CH2Et2-Br, 4-F
2149FCH2—CH═CH—CH2Et2-Br, 4-NO2
2150FCH2—CH═CH—CH2Et2-Br, 4-NH2
2151FCH2—CH═CH—CH2Et2-Br, 4-NHMe
2152FCH2—CH═CH—CH2Et2-Br, 4-NMe2
2153FCH2—CH═CH—CH2Et2-Br, 4-
NMe3OTf
2154FCH2—CH═CH—CH2Et2-Br, 4-NMe3I
2155FCH2—CH═CH—CH2Et2-Br, 5-F
2156FCH2—CH═CH—CH2Et2-Br, 5-NO2
2157FCH2—CH═CH—CH2Et2-Br, 5-NH2
2158FCH2—CH═CH—CH2Et2-Br, 5-NHMe
2159FCH2—CH═CH—CH2Et2-Br, 5-NMe2
2160FCH2—CH═CH—CH2Et2-Br, 5-
NMe3OTf
2161FCH2—CH═CH—CH2Et2-Br, 5-NMe3I
2162FCH2—CH═CH—CH2Et2-F, 4-Br
2163FCH2—CH═CH—CH2Et2-NO2, 4-Br
2164FCH2—CH═CH—CH2Et2-NH2, 4-Br
2165FCH2—CH═CH—CH2Et2-NHMe, 4-Br
2166FCH2—CH═CH—CH2Et2-NMe2, 4-Br
2167FCH2—CH═CH—CH2Et2-NMe3OTf, 4-
Br
2168FCH2—CH═CH—CH2Et2-NMe3I, 4-Br
2169FCH2—CH═CH—CH2Et2-I, 4-F
2170FCH2—CH═CH—CH2Et2-I, 4-NO2
2171FCH2—CH═CH—CH2Et2-I, 4-NH2
2172FCH2—CH═CH—CH2Et2-I, 4-NHMe
2173FCH2—CH═CH—CH2Et2-I, 4-NMe2
2174FCH2—CH═CH—CH2Et2-I, 4-NMe3OTf
2175FCH2—CH═CH—CH2Et2-I, 4-NMe3I
2176FCH2—CH═CH—CH2Et2-F, 4-I
2177FCH2—CH═CH—CH2Et2-NO2, 4-I
2178FCH2—CH═CH—CH2Et2-NH2, 4-I
2179FCH2—CH═CH—CH2Et2-NHMe, 4-I
2180FCH2—CH═CH—CH2Et2-NMe2, 4-I
2181FCH2—CH═CH—CH2Et2-NMe3OTf, 4-I
2182FCH2—CH═CH—CH2Et2-NMe3I, 4-I
2183FCH2—CH═CH—CH2Et2-Me, 3-F
2184FCH2—CH═CH—CH2Et2-Me, 3-NO2
2185FCH2—CH═CH—CH2Et2-Me, 3-NH2
2186FCH2—CH═CH—CH2Et2-Me, 3-NHMe
2187FCH2—CH═CH—CH2Et2-Me, 3-NMe2
2188FCH2—CH═CH—CH2Et2-Me, 3-
NMe3OTf
2189FCH2—CH═CH—CH2Et2-Me, 3-NMe3I
2190FCH2—CH═CH—CH2Et2-Me, 4-F
2191FCH2—CH═CH—CH2Et2-Me, 4-NO2
2192FCH2—CH═CH—CH2Et2-Me, 4-NH2
2193FCH2—CH═CH—CH2Et2-Me, 4-NHMe
2194FCH2—CH═CH—CH2Et2-Me, 4-NMe2
2195FCH2—CH═CH—CH2Et2-Me, 4-
NMe3OTf
2196FCH2—CH═CH—CH2Et2-Me, 4-NMe3I
2197FCH2—CH═CH—CH2Et2-Me, 5-F
2198FCH2—CH═CH—CH2Et2-Me, 5-NO2
2199FCH2—CH═CH—CH2Et2-Me, 5-NH2
2200FCH2—CH═CH—CH2Et2-Me, 5-NHMe
2201FCH2—CH═CH—CH2Et2-Me, 5-NMe2
2202FCH2—CH═CH—CH2Et2-Me, 5-
NMe3OTf
2203FCH2—CH═CH—CH2Et2-Me, 5-NMe3I
2204FCH2—CH═CH—CH2Et2-F, 4-Me
2205FCH2—CH═CH—CH2Et2-NO2, 4-Me
2206FCH2—CH═CH—CH2Et2-NH2, 4-Me
2207FCH2—CH═CH—CH2Et2-NHMe, 4-Me
2208FCH2—CH═CH—CH2Et2-NMe2, 4-Me
2209FCH2—CH═CH—CH2Et2-NMe3, 4-Me
2210FCH2—CH═CH—CH2Et2-NMe3OTf, 4-
Me
2211FCH2—CH═CH—CH2Et2-NMe3I, 4-Me
2212FCH2—CH═CH—CH2Et2-SnMe3, 4-F
2213FCH2—CH═CH—CH2Et2-SnMe3, 5-F
2214FCH2—CH═CH—CH2Et2-F, 4-SnMe3
2215FCH2—CH═CH—CH2Et2-Br, 6-Cl, 4-F
2216FCH2—CH═CH—CH2Et2-Br, 6-Cl, 4-
NO2
2217FCH2—CH═CH—CH2Et2-Br, 6-Cl, 4-
NH2
2218FCH2—CH═CH—CH2Et2-Br, 6-Cl, 4-
NHMe
2219FCH2—CH═CH—CH2Et2-Br, 6-Cl, 4-
NMe2
2220FCH2—CH═CH—CH2Et2-Br, 6-Cl 4-
NMe3OTf
2221FCH2—CH═CH—CH2Et2-Br, 6-Cl, 4-
NMe3I
2222FCH2—CH═CH—CH2Et2-Me, 6-Cl, 4-F
2223FCH2—CH═CH—CH2Et2-SnMe3, 6-Cl, 4-
F
2224FCH2—CH═CH—CH2Et2-Cl, 4-Me
2225FCH2—CH═CH—CH2Et2-Cl, 4-Br
2226FCH2—CH═CH—CH2Et2-Cl, 4-SnMe3
2227FCH2—CH═CH—CH2Et2-Br, 4-Cl
2228FCH2—CH═CH—CH2Et2-SnMe3, 4-Cl
2229FCH2—CH═CH—CH2Et2-Me, 4-Cl
2230FCH2—CH═CH—CH2Et2-Br, 4-Br
2231FCH2—CH═CH—CH2Et2-Br, 4-Me
2232FCH2—CH═CH—CH2Et2-Br, 4-SnMe3
2233FCH2—CH═CH—CH2Et2-SnMe3, 4-Br
2234FCH2—CH═CH—CH2Et2-Me, 4-Br
2235FCH2—CH═CH—CH2Et2-Me, 4-SnMe3
2236FCH2—CH═CH—CH2Et2-SnMe3, 4-Me
2237FCH2—CH═CH—CH2Et2-Me, 4-Me
2238FCH2—CH═CH—CH2Et2-Et, 4-Br
2239FCH2—CH═CH—CH2Et2-Et, 4-SnMe3
2240FCH2—CH═CH—CH2Et2-Et, 4-Me
2241FCH2—CH═CH—CH2Et2-Me, 4-Me, 6-Me
2242FCH2—CH═CH—CH2Et2-Me, 4-Br, 6-Me
2243FCH2—CH═CH—CH2Et2-Me, 4-SnMe3,
6-Me
2244FCH2—CH═CH—CH2Et2-Et, 6-Me
2245FCH2—CH═CH—CH2Et2-Br, 4-i-Pr
2246FCH2—CH═CH—CH2Et2-SnMe3, 4-i-Pr
2247FCH2—CH═CH—CH2Et2-Me, 4-i-Pr
2248FCH2—CH═CH—CH2Et2-Br, 4-Br, 6-Br
2249FCH2—CH═CH—CH2Et2-Br, 4-Me, 6-Br
2250FCH2—CH═CH—CH2Et2-Br, 4-SnMe3,
6-Br
2251FCH2—CH═CH—CH2Et2-SnMe3, 4-Br,
6-Br
2252FCH2—CH═CH—CH2Et2-Br, 4-Br, 6-Me
2253FCH2—CH═CH—CH2Et2-Br, 4-CF3, 6-Br
2254FCH2—CH═CH—CH2Et2-Br, 4-Br, 6-CF3
2255FCH2—CH═CH—CH2Et2-CF3, 4-CF3
2256FCH2—CH═CH—CH2Et2-Cl, 4-CF3
2257FCH2—CH═CH—CH2Et2-CF3, 4-Cl
2258FCH2—CH═CH—CH2Et2-Br, 4-CF3
2259FCH2—CH═CH—CH2Et2-SnMe3, 4-CF3
2260FCH2—CH═CH—CH2Et2-Me, 4-CF3
2261FCH2—CH═CH—CH2Et2-CF3, 4-Br
2262FCH2—CH═CH—CH2Et2-CF3, 4-SnMe3
2263FCH2—CH═CH—CH2Et2-CF3, 4-Me
2264FCH2—CH═CH—CH2Et2-Br, 4-OH
2265FCH2—CH═CH—CH2Et2-Br, 4-OMe
2266FCH2—CH═CH—CH2Et2-Br, 4-OMeF
2267FCH2—CH═CH—CH2Et2-Br, 4-OCF3
2268FCH2—CH═CH—CH2Et2-Br, 4-OEtF
2269FCH2—CH═CH—CH2Et2-Br, 4-OPrF
2270FCH2—CH═CH—CH2Et2-OH, 4-Br
2271FCH2—CH═CH—CH2Et2-OMe, 4-Br
2272FCH2—CH═CH—CH2Et2-OMeF, 4-Br
2273FCH2—CH═CH—CH2Et2-OCF3, 4-Br
2274FCH2—CH═CH—CH2Et2-OEtF, 4-Br
2275FCH2—CH═CH—CH2Et2-OPrF, 4-Br
2276FCH2—CH═CH—CH2Et2-I, 4-OH
2277FCH2—CH═CH—CH2Et2-I, 4-OMe
2278FCH2—CH═CH—CH2Et2-I, 4-OMeF
2279FCH2—CH═CH—CH2Et2-I, 4-OCF3
2280FCH2—CH═CH—CH2Et2-I, 4-OEtF
2281FCH2—CH═CH—CH2Et2-I, 4-OPrF
2282FCH2—CH═CH—CH2Et2-OH, 4-I
2283FCH2—CH═CH—CH2Et2-OMe, 4-I
2284FCH2—CH═CH—CH2Et2-OMeF, 4-I
2285FCH2—CH═CH—CH2Et2-OCF3, 4-I
2286FCH2—CH═CH—CH2Et2-OEtF, 4-I
2287FCH2—CH═CH—CH2Et2-OPrF, 4-I
2288FCH2—CH═CH—CH2Et2-SnMe3, 4-OH
2289FCH2—CH═CH—CH2Et2-SnMe3, 4-OMe
2290FCH2—CH═CH—CH2Et2-SnMe3, 4-
OMeF
2291FCH2—CH═CH—CH2Et2-SnMe3, 4-OCF3
2292FCH2—CH═CH—CH2Et2-SnMe3, 4-OEtF
2293FCH2—CH═CH—CH2Et2-SnMe3, 4-OPrF
2294FCH2—CH═CH—CH2Et2-OH, 4-SnMe3
2295FCH2—CH═CH—CH2Et2-OMe, 4-SnMe3
2296FCH2—CH═CH—CH2Et2-OMeF, 4-
SnMe3
2297FCH2—CH═CH—CH2Et2-OCF3, 4-SnMe3
2298FCH2—CH═CH—CH2Et2-OEtF, 4-SnMe3
2299FCH2—CH═CH—CH2Et2-OPrF, 4-SnMe3
2300FCH2—CH═CH—CH2Et—FH
2301FCH2—CH═CH—CH2Et—F2-t-Bu
2302FCH2—CH═CH—CH2Et—F2-Br
2303FCH2—CH═CH—CH2Et—F3-Br
2304FCH2—CH═CH—CH2Et—F4-Br
2305FCH2—CH═CH—CH2Et—F2-I
2306FCH2—CH═CH—CH2Et—F3-I
2307FCH2—CH═CH—CH2Et—F4-I
2308FCH2—CH═CH—CH2Et—F2-SnMe3
2309FCH2—CH═CH—CH2Et—F3-SnMe3
2310FCH2—CH═CH—CH2Et—F4-SnMe3
2311FCH2—CH═CH—CH2Et—F2-Me
2312FCH2—CH═CH—CH2Et—F3-Me
2313FCH2—CH═CH—CH2Et—F4-Me
2314FCH2—CH═CH—CH2Et—F2-OH
2315FCH2—CH═CH—CH2Et—F3-OH
2316FCH2—CH═CH—CH2Et—F4-OH
2317FCH2—CH═CH—CH2Et—F2-OMe
2318FCH2—CH═CH—CH2Et—F3-OMe
2319FCH2—CH═CH—CH2Et—F4-OMe
2320FCH2—CH═CH—CH2Et—F2-OMeF
2321FCH2—CH═CH—CH2Et—F3-OMeF
2322FCH2—CH═CH—CH2Et—F4-OMeF
2323FCH2—CH═CH—CH2Et—F2-OCF3
2324FCH2—CH═CH—CH2Et—F3-OCF3
2325FCH2—CH═CH—CH2Et—F4-OCF3
2326FCH2—CH═CH—CH2Et—F2-OEtF
2327FCH2—CH═CH—CH2Et—F3-OEtF
2328FCH2—CH═CH—CH2Et—F4-OEtF
2329FCH2—CH═CH—CH2Et—F2-OPrF
2330FCH2—CH═CH—CH2Et—F3-OPrF
2331FCH2—CH═CH—CH2Et—F4-OPrF
2332FCH2—CH═CH—CH2Et—F2-SH
2333FCH2—CH═CH—CH2Et—F3-SH
2334FCH2—CH═CH—CH2Et—F4-SH
2335FCH2—CH═CH—CH2Et—F2-SMe
2336FCH2—CH═CH—CH2Et—F3-SMe
2337FCH2—CH═CH—CH2Et—F4-SMe
2338FCH2—CH═CH—CH2Et—F2-SMeF
2339FCH2—CH═CH—CH2Et—F3-SMeF
2340FCH2—CH═CH—CH2Et—F4-SMeF
2341FCH2—CH═CH—CH2Et—F2-SCF3
2342FCH2—CH═CH—CH2Et—F3-SCF3
2343FCH2—CH═CH—CH2Et—F4-SCF3
2344FCH2—CH═CH—CH2Et—F2-SEtF
2345FCH2—CH═CH—CH2Et—F3-SEtF
2346FCH2—CH═CH—CH2Et—F4-SEtF
2347FCH2—CH═CH—CH2Et—F2-SPrF
2348FCH2—CH═CH—CH2Et—F3-SPrF
2349FCH2—CH═CH—CH2Et—F4-SPrF
2350FCH2—CH═CH—CH2Et—F2-OMe, 4-OMe
2351FCH2—CH═CH—CH2Et—F2-Me, 5-OH
2352FCH2—CH═CH—CH2Et—F2-Me, 5-OMe
2353FCH2—CH═CH—CH2Et—F2-Me, 5-OMeF
2354FCH2—CH═CH—CH2Et—F2-Me, 5-OEtF
2355FCH2—CH═CH—CH2Et—F2-Me, 5-OPrF
2356FCH2—CH═CH—CH2Et—F2-Me, 4-OH
2357FCH2—CH═CH—CH2Et—F2-Me, 4-OMe
2358FCH2—CH═CH—CH2Et—F2-Me, 4-OMeF
2359FCH2—CH═CH—CH2Et—F2-Me, 4-OCF3
2360FCH2—CH═CH—CH2Et—F2-Me, 4-OEtF
2361FCH2—CH═CH—CH2Et—F2-Me, 4-OPrF
2362FCH2—CH═CH—CH2Et—F2-OH, 4-Me
2363FCH2—CH═CH—CH2Et—F2-OMe, 4-Me
2364FCH2—CH═CH—CH2Et—F2-OMeF, 4-Me
2365FCH2—CH═CH—CH2Et—F2-OCF3, 4-Me
2366FCH2—CH═CH—CH2Et—F2-OEtF, 4-Me
2367FCH2—CH═CH—CH2Et—F2-OPrF, 4-Me
2368FCH2—CH═CH—CH2Et—F2-Cl, 4-OH
2369FCH2—CH═CH—CH2Et—F2-Cl, 4-OMe
2370FCH2—CH═CH—CH2Et—F2-Cl, 4-OMeF
2371FCH2—CH═CH—CH2Et—F2-Cl, 4-OCF3
2372FCH2—CH═CH—CH2Et—F2-Cl, 4-OEtF
2373FCH2—CH═CH—CH2Et—F2-Cl, 4-OPrF
2374FCH2—CH═CH—CH2Et—F2-F, 4-F
2375FCH2—CH═CH—CH2Et—F2-Cl, 4-Cl
2376FCH2—CH═CH—CH2Et—F2-Cl, 4-F
2377FCH2—CH═CH—CH2Et—F2-Cl, 4-NO2
2378FCH2—CH═CH—CH2Et—F2-Cl, 4-NH2
2379FCH2—CH═CH—CH2Et—F2-Cl, 4-NHMe
2380FCH2—CH═CH—CH2Et—F2-Cl, 4-NMe2
2381FCH2—CH═CH—CH2Et—F2-Cl, 4-NMe3OTf
2382FCH2—CH═CH—CH2Et—F2-Cl, 4-NMe3I
2383FCH2—CH═CH—CH2Et—F2-Cl, 5-F
2384FCH2—CH═CH—CH2Et—F2-Cl, 5-NO2
2385FCH2—CH═CH—CH2Et—F2-Cl, 5-NH2
2386FCH2—CH═CH—CH2Et—F2-Cl, 5-NHMe
2387FCH2—CH═CH—CH2Et—F2-Cl, 5-NMe2
2388FCH2—CH═CH—CH2Et—F2-Cl, 5-NMe3OTf
2389FCH2—CH═CH—CH2Et—F2-Cl, 5-NMe3I
2390FCH2—CH═CH—CH2Et—F2-F, 4-Cl
2391FCH2—CH═CH—CH2Et—F2-NO2, 4-Cl
2392FCH2—CH═CH—CH2Et—F2-NH2, 4-Cl
2393FCH2—CH═CH—CH2Et—F2-NHMe, 4-Cl
2394FCH2—CH═CH—CH2Et—F2-NMe2, 4-Cl
2395FCH2—CH═CH—CH2Et—F2-NMe3OTf, 4-Cl
2396FCH2—CH═CH—CH2Et—F2-NMe3I, 4-Cl
2397FCH2—CH═CH—CH2Et—F2-F, 5-Cl
2398FCH2—CH═CH—CH2Et—F2-NO2, 5-Cl
2399FCH2—CH═CH—CH2Et—F2-NH2, 5-Cl
2400FCH2—CH═CH—CH2Et—F2-NHMe, 5-Cl
2401FCH2—CH═CH—CH2Et—F2-NMe2, 5-Cl
2402FCH2—CH═CH—CH2Et—F2-NMe3OTf, 5-Cl
2403FCH2—CH═CH—CH2Et—F2-NMe3I, 5-Cl
2404FCH2—CH═CH—CH2Et—F2-Br, 4-F
2405FCH2—CH═CH—CH2Et—F2-Br, 4-NO2
2406FCH2—CH═CH—CH2Et—F2-Br, 4-NH2
2407FCH2—CH═CH—CH2Et—F2-Br, 4-NHMe
2408FCH2—CH═CH—CH2Et—F2-Br, 4-NMe2
2409FCH2—CH═CH—CH2Et—F2-Br, 4-
NMe3OTf
2410FCH2—CH═CH—CH2Et—F2-Br, 4-NMe3I
2411FCH2—CH═CH—CH2Et—F2-Br, 5-F
2412FCH2—CH═CH—CH2Et—F2-Br, 5-NO2
2413FCH2—CH═CH—CH2Et—F2-Br, 5-NH2
2414FCH2—CH═CH—CH2Et—F2-Br, 5-NHMe
2415FCH2—CH═CH—CH2Et—F2-Br, 5-NMe2
2416FCH2—CH═CH—CH2Et—F2-Br, 5-
NMe3OTf
2417FCH2—CH═CH—CH2Et—F2-Br, 5-NMe3I
2418FCH2—CH═CH—CH2Et—F2-F, 4-Br
2419FCH2—CH═CH—CH2Et—F2-NO2, 4-Br
2420FCH2—CH═CH—CH2Et—F2-NH2, 4-Br
2421FCH2—CH═CH—CH2Et—F2-NHMe, 4-Br
2422FCH2—CH═CH—CH2Et—F2-NMe2, 4-Br
2423FCH2—CH═CH—CH2Et—F2-NMe3OTf, 4-
Br
2424FCH2—CH═CH—CH2Et—F2-NMe3I, 4-Br
2425FCH2—CH═CH—CH2Et—F2-I, 4-F
2426FCH2—CH═CH—CH2Et—F2-I, 4-NO2
2427FCH2—CH═CH—CH2Et—F2-I, 4-NH2
2428FCH2—CH═CH—CH2Et—F2-I, 4-NHMe
2429FCH2—CH═CH—CH2Et—F2-I, 4-NMe2
2430FCH2—CH═CH—CH2Et—F2-I, 4-NMe3OTf
2431FCH2—CH═CH—CH2Et—F2-I, 4-NMe3I
2432FCH2—CH═CH—CH2Et—F2-F, 4-I
2433FCH2—CH═CH—CH2Et—F2-NO2, 4-I
2434FCH2—CH═CH—CH2Et—F2-NH2, 4-I
2435FCH2—CH═CH—CH2Et—F2-NHMe, 4-I
2436FCH2—CH═CH—CH2Et—F2-NMe2, 4-I
2437FCH2—CH═CH—CH2Et—F2-NMe3OTf, 4-I
2438FCH2—CH═CH—CH2Et—F2-NMe3I, 4-I
2439FCH2—CH═CH—CH2Et—F2-Me, 3-F
2440FCH2—CH═CH—CH2Et—F2-Me, 3-NO2
2441FCH2—CH═CH—CH2Et—F2-Me, 3-NH2
2442FCH2—CH═CH—CH2Et—F2-Me, 3-NHMe
2443FCH2—CH═CH—CH2Et—F2-Me, 3-NMe2
2444FCH2—CH═CH—CH2Et—F2-Me, 3-
NMe3OTf
2445FCH2—CH═CH—CH2Et—F2-Me, 3-NMe3I
2446FCH2—CH═CH—CH2Et—F2-Me, 4-F
2447FCH2—CH═CH—CH2Et—F2-Me, 4-NO2
2448FCH2—CH═CH—CH2Et—F2-Me, 4-NH2
2449FCH2—CH═CH—CH2Et—F2-Me, 4-NHMe
2450FCH2—CH═CH—CH2Et—F2-Me, 4-NMe2
2451FCH2—CH═CH—CH2Et—F2-Me, 4-
NMe3OTf
2452FCH2—CH═CH—CH2Et—F2-Me, 4-NMe3I
2453FCH2—CH═CH—CH2Et—F2-Me, 5-F
2454FCH2—CH═CH—CH2Et—F2-Me, 5-NO2
2455FCH2—CH═CH—CH2Et—F2-Me, 5-NH2
2456FCH2—CH═CH—CH2Et—F2-Me, 5-NHMe
2457FCH2—CH═CH—CH2Et—F2-Me, 5-NMe2
2458FCH2—CH═CH—CH2Et—F2-Me, 5-
NMe3OTf
2459FCH2—CH═CH—CH2Et—F2-Me, 5-NMe3I
2460FCH2—CH═CH—CH2Et—F2-F, 4-Me
2461FCH2—CH═CH—CH2Et—F2-NO2, 4-Me
2462FCH2—CH═CH—CH2Et—F2-NH2, 4-Me
2463FCH2—CH═CH—CH2Et—F2-NHMe, 4-Me
2464FCH2—CH═CH—CH2Et—F2-NMe2, 4-Me
2465FCH2—CH═CH—CH2Et—F2-NMe3, 4-Me
2466FCH2—CH═CH—CH2Et—F2-NMe3OTf, 4-
Me
2467FCH2—CH═CH—CH2Et—F2-NMe3I, 4-Me
2468FCH2—CH═CH—CH2Et—F2-SnMe3, 4-F
2469FCH2—CH═CH—CH2Et—F2-SnMe3, 5-F
2470FCH2—CH═CH—CH2Et—F2-F, 4-SnMe3
2471FCH2—CH═CH—CH2Et—F2-Br, 6-Cl, 4-F
2472FCH2—CH═CH—CH2Et—F2-Br, 6-Cl, 4-
NO2
2473FCH2—CH═CH—CH2Et—F2-Br, 6-Cl, 4-
NH2
2474FCH2—CH═CH—CH2Et—F2-Br, 6-Cl, 4-
NHMe
2475FCH2—CH═CH—CH2Et—F2-Br, 6-Cl, 4-
NMe2
2476FCH2—CH═CH—CH2Et—F2-Br, 6-Cl 4-
NMe3OTf
2477FCH2—CH═CH—CH2Et—F2-Br, 6-Cl, 4-
NMe3I
2478FCH2—CH═CH—CH2Et—F2-Me, 6-Cl, 4-F
2479FCH2—CH═CH—CH2Et—F2-SnMe3, 6-Cl, 4-
F
2480FCH2—CH═CH—CH2Et—F2-Cl, 4-Me
2481FCH2—CH═CH—CH2Et—F2-Cl, 4-Br
2482FCH2—CH═CH—CH2Et—F2-Cl, 4-SnMe3
2483FCH2—CH═CH—CH2Et—F2-Br, 4-Cl
2484FCH2—CH═CH—CH2Et—F2-SnMe3, 4-Cl
2485FCH2—CH═CH—CH2Et—F2-Me, 4-Cl
2486FCH2—CH═CH—CH2Et—F2-Br, 4-Br
2487FCH2—CH═CH—CH2Et—F2-Br, 4-Me
2488FCH2—CH═CH—CH2Et—F2-Br, 4-SnMe3
2489FCH2—CH═CH—CH2Et—F2-SnMe3, 4-Br
2490FCH2—CH═CH—CH2Et—F2-Me, 4-Br
2491FCH2—CH═CH—CH2Et—F2-Me, 4-SnMe3
2492FCH2—CH═CH—CH2Et—F2-SnMe3, 4-Me
2493FCH2—CH═CH—CH2Et—F2-Me, 4-Me
2494FCH2—CH═CH—CH2Et—F2-Et, 4-Br
2495FCH2—CH═CH—CH2Et—F2-Et, 4-SnMe3
2496FCH2—CH═CH—CH2Et—F2-Et, 4-Me
2497FCH2—CH═CH—CH2Et—F2-Me, 4-Me, 6-Me
2498FCH2—CH═CH—CH2Et—F2-Me, 4-Br, 6-Me
2499FCH2—CH═CH—CH2Et—F2-Me, 4-SnMe3,
6-Me
2500FCH2—CH═CH—CH2Et—F2-Et, 6-Me
2501FCH2—CH═CH—CH2Et—F2-Br, 4-i-Pr
2502FCH2—CH═CH—CH2Et—F2-SnMe3, 4-i-Pr
2503FCH2—CH═CH—CH2Et—F2-Me, 4-i-Pr
2504FCH2—CH═CH—CH2Et—F2-Br, 4-Br, 6-Br
2505FCH2—CH═CH—CH2Et—F2-Br, 4-Me, 6-Br
2506FCH2—CH═CH—CH2Et—F2-Br, 4-SnMe3,
6-Br
2507FCH2—CH═CH—CH2Et—F2-SnMe3, 4-Br,
6-Br
2508FCH2—CH═CH—CH2Et—F2-Br, 4-Br, 6-Me
2509FCH2—CH═CH—CH2Et—F2-Br, 4-CF3, 6-Br
2510FCH2—CH═CH—CH2Et—F2-Br, 4-Br, 6-CF3
2511FCH2—CH═CH—CH2Et—F2-CF3, 4-CF3
2512FCH2—CH═CH—CH2Et—F2-Cl, 4-CF3
2513FCH2—CH═CH—CH2Et—F2-CF3, 4-Cl
2514FCH2—CH═CH—CH2Et—F2-Br, 4-CF3
2515FCH2—CH═CH—CH2Et—F2-SnMe3, 4-CF3
2516FCH2—CH═CH—CH2Et—F2-Me, 4-CF3
2517FCH2—CH═CH—CH2Et—F2-CF3, 4-Br
2518FCH2—CH═CH—CH2Et—F2-CF3, 4-SnMe3
2519FCH2—CH═CH—CH2Et—F2-CF3, 4-Me
2520FCH2—CH═CH—CH2Et—F2-Br, 4-OH
2521FCH2—CH═CH—CH2Et—F2-Br, 4-OMe
2522FCH2—CH═CH—CH2Et—F2-Br, 4-OMeF
2523FCH2—CH═CH—CH2Et—F2-Br, 4-OCF3
2524FCH2—CH═CH—CH2Et—F2-Br, 4-OEtF
2525FCH2—CH═CH—CH2Et—F2-Br, 4-OPrF
2526FCH2—CH═CH—CH2Et—F2-OH, 4-Br
2527FCH2—CH═CH—CH2Et—F2-OMe, 4-Br
2528FCH2—CH═CH—CH2Et—F2-OMeF, 4-Br
2529FCH2—CH═CH—CH2Et—F2-OCF3, 4-Br
2530FCH2—CH═CH—CH2Et—F2-OEtF, 4-Br
2531FCH2—CH═CH—CH2Et—F2-OPrF, 4-Br
2532FCH2—CH═CH—CH2Et—F2-I, 4-OH
2533FCH2—CH═CH—CH2Et—F2-I, 4-OMe
2534FCH2—CH═CH—CH2Et—F2-I, 4-OMeF
2535FCH2—CH═CH—CH2Et—F2-I, 4-OCF3
2536FCH2—CH═CH—CH2Et—F2-I, 4-OEtF
2537FCH2—CH═CH—CH2Et—F2-I, 4-OPrF
2538FCH2—CH═CH—CH2Et—F2-OH, 4-I
2539FCH2—CH═CH—CH2Et—F2-OMe, 4-I
2540FCH2—CH═CH—CH2Et—F2-OMeF, 4-I
2541FCH2—CH═CH—CH2Et—F2-OCF3, 4-I
2542FCH2—CH═CH—CH2Et—F2-OEtF, 4-I
2543FCH2—CH═CH—CH2Et—F2-OPrF, 4-I
2544FCH2—CH═CH—CH2Et—F2-SnMe3, 4-OH
2545FCH2—CH═CH—CH2Et—F2-SnMe3, 4-OMe
2546FCH2—CH═CH—CH2Et—F2-SnMe3, 4-
OMeF
2547FCH2—CH═CH—CH2Et—F2-SnMe3, 4-OCF3
2548FCH2—CH═CH—CH2Et—F2-SnMe3, 4-OEtF
2549FCH2—CH═CH—CH2Et—F2-SnMe3, 4-OPrF
2550FCH2—CH═CH—CH2Et—F2-OH, 4-SnMe3
2551FCH2—CH═CH—CH2Et—F2-OMe, 4-SnMe3
2552FCH2—CH═CH—CH2Et—F2-OMeF, 4-
SnMe3
2553FCH2—CH═CH—CH2Et—F2-OCF3, 4-SnMe3
2554FCH2—CH═CH—CH2Et—F2-OEtF, 4-SnMe3
2555FCH2—CH═CH—CH2Et—F2-OPrF, 4-SnMe3

TABLE 2
Substituent list for compounds of general structure VII.
VII
embedded image
Compound #R1 =R2 =R4 =X2 =
2556BuEtHH
2557BuEtHSnMe3
2558BuEtHBr
2559BuEtHI
2560BuEt4-FH
2561BuEt4-FSnMe3
2562BuEt4-FBr
2563BuEt4-FI
2564BuEt5-FH
2565BuEt5-FSnMe3
2566BuEt5-FBr
2567BuEt5-FI
2568BuEt4-ClH
2569BuEt4-ClSnMe3
2570BuEt4-ClBr
2571BuEt4-ClI
2572BuEt4-BrH
2573BuEt4-BrSnMe3
2574BuEt4-BrBr
2575BuEt4-BrI
2576BuEt4-MeH
2577BuEt4-MeSnMe3
2578BuEt4-MeBr
2579BuEt4-MeI
2580BuEt4-CF3H
2581BuEt4-CF3SnMe3
2582BuEt4-CF3Br
2583BuEt4-CF3I
2584BuEt4-OHH
2585BuEt4-OHSnMe3
2586BuEt4-OHBr
2587BuEt4-OHI
2588BuEt4-OMeH
2589BuEt4-OMeSnMe3
2590BuEt4-OMeBr
2591BuEt4-OMeI
2592BuEt4-OMeFH
2593BuEt4-OMeFSnMe3
2594BuEt4-OMeFBr
2595BuEt4-OMeFI
2596BuEt4-OCF3H
2597BuEt4-OCF3SnMe3
2598BuEt4-OCF3Br
2599BuEt4-OCF3I
2600BuEt4-OEtFH
2601BuEt4-OEtFSnMe3
2602BuEt4-OEtFBr
2603BuEt4-OEtFI
2604BuEt4-OPrFH
2605BuEt4-OPrFSnMe3
2606BuEt4-OPrFBr
2607BuEt4-OPrFI
2608BuEt4-i-PrH
2609BuEt4-i-PrSnMe3
2610BuEt4-i-PrBr
2611BuEt4-i-PrI
2612BuEt2-Br, 4-CF3H
2613BuEt2-Br, 4-CF3SnMe3
2614BuEt2-Br, 4-CF3Br
2615BuEt2-Br, 4-CF3I
2616BuEt2-CF3, 4-BrH
2617BuEt2-CF3, 4-BrSnMe3
2618BuEt2-CF3, 4-BrBr
2619BuEt2-CF3, 4-BrI
2620BuEt2-Br, 4-BrH
2621BuEt2-Br, 4-BrSnMe3
2622BuEt2-Br, 4-BrBr
2623BuEt2-Br, 4-BrI
2624BuEt2-Br, 4-MeH
2625BuEt2-Br, 4-MeSnMe3
2626BuEt2-Br, 4-MeBr
2627BuEt2-Br, 4-MeI
2628PrPrHH
2629PrPrHSnMe3
2630PrPrHBr
2631PrPrHI
2632PrPr4-FH
2633PrPr4-FSnMe3
2634PrPr4-FBr
2635PrPr4-FI
2636PrPr5-FH
2637PrPr5-FSnMe3
2638PrPr5-FBr
2639PrPr5-FI
2640PrPr4-ClH
2641PrPr4-ClSnMe3
2642PrPr4-ClBr
2643PrPr4-ClI
2644PrPr4-BrH
2645PrPr4-BrSnMe3
2646PrPr4-BrBr
2647PrPr4-BrI
2648PrPr4-MeH
2649PrPr4-MeSnMe3
2650PrPr4-MeBr
2651PrPr4-MeI
2652PrPr4-CF3H
2653PrPr4-CF3SnMe3
2654PrPr4-CF3Br
2655PrPr4-CF3I
2656PrPr4-OHH
2657PrPr4-OHSnMe3
2658PrPr4-OHBr
2659PrPr4-OHI
2660PrPr4-OMeH
2661PrPr4-OMeSnMe3
2662PrPr4-OMeBr
2663PrPr4-OMeI
2664PrPr4-OMeFH
2665PrPr4-OMeFSnMe3
2666PrPr4-OMeFBr
2667PrPr4-OMeFI
2668PrPr4-OCF3H
2669PrPr4-OCF3SnMe3
2670PrPr4-OCF3Br
2671PrPr4-OCF3I
2672PrPr4-OEtFH
2673PrPr4-OEtFSnMe3
2674PrPr4-OEtFBr
2675PrPr4-OEtFI
2676PrPr4-OPrFH
2677PrPr4-OPrFSnMe3
2678PrPr4-OPrFBr
2679PrPr4-OPrFI
2680PrPr4-i-PrH
2681PrPr4-i-PrSnMe3
2682PrPr4-i-PrBr
2683PrPr4-i-PrI
2684PrPr2-Br, 4-CF3H
2685PrPr2-Br, 4-CF3SnMe3
2686PrPr2-Br, 4-CF3Br
2687PrPr2-Br, 4-CF3I
2688PrPr2-CF3, 4-BrH
2689PrPr2-CF3, 4-BrSnMe3
2690PrPr2-CF3, 4-BrBr
2691PrPr2-CF3, 4-BrI
2692PrPr2-Br, 4-BrH
2693PrPr2-Br, 4-BrSnMe3
2694PrPr2-Br, 4-BrBr
2695PrPr2-Br, 4-BrI
2696PrPr2-Br, 4-MeH
2697PrPr2-Br, 4-MeSnMe3
2698PrPr2-Br, 4-MeBr
2699PrPr2-Br, 4-MeI
2700PrPr-FHH
2701PrPr-FHSnMe3
2702PrPr-FHBr
2703PrPr-FHI
2704PrPr-F4-FH
2705PrPr-F4-FSnMe3
2706PrPr-F4-FBr
2707PrPr-F4-FI
2708PrPr-F5-FH
2709PrPr-F5-FSnMe3
2710PrPr-F5-FBr
2711PrPr-F5-FI
2712PrPr-F4-ClH
2713PrPr-F4-ClSnMe3
2714PrPr-F4-ClBr
2715PrPr-F4-ClI
2716PrPr-F4-BrH
2717PrPr-F4-BrSnMe3
2718PrPr-F4-BrBr
2719PrPr-F4-BrI
2720PrPr-F4-MeH
2721PrPr-F4-MeSnMe3
2722PrPr-F4-MeBr
2723PrPr-F4-MeI
2724PrPr-F4-CF3H
2725PrPr-F4-CF3SnMe3
2726PrPr-F4-CF3Br
2727PrPr-F4-CF3I
2728PrPr-F4-OHH
2729PrPr-F4-OHSnMe3
2730PrPr-F4-OHBr
2731PrPr-F4-OHI
2732PrPr-F4-OMeH
2733PrPr-F4-OMeSnMe3
2734PrPr-F4-OMeBr
2735PrPr-F4-OMeI
2736PrPr-F4-OMeFH
2737PrPr-F4-OMeFSnMe3
2738PrPr-F4-OMeFBr
2739PrPr-F4-OMeFI
2740PrPr-F4-OCF3H
2741PrPr-F4-OCF3SnMe3
2742PrPr-F4-OCF3Br
2743PrPr-F4-OCF3I
2744PrPr-F4-OEtFH
2745PrPr-F4-OEtFSnMe3
2746PrPr-F4-OEtFBr
2747PrPr-F4-OEtFI
2748PrPr-F4-OPrFH
2749PrPr-F4-OPrFSnMe3
2750PrPr-F4-OPrFBr
2751PrPr-F4-OPrFI
2752PrPr-F4-i-PrH
2753PrPr-F4-i-PrSnMe3
2754PrPr-F4-i-PrBr
2755PrPr-F4-i-PrI
2756PrPr-F2-Br, 4-CF3H
2757PrPr-F2-Br, 4-CF3SnMe3
2758PrPr-F2-Br, 4-CF3Br
2759PrPr-F2-Br, 4-CF3I
2760PrPr-F2-CF3, 4-BrH
2761PrPr-F2-CF3, 4-BrSnMe3
2762PrPr-F2-CF3, 4-BrBr
2763PrPr-F2-CF3, 4-BrI
2764PrPr-F2-Br, 4-BrH
2765PrPr-F2-Br, 4-BrSnMe3
2766PrPr-F2-Br, 4-BrBr
2767PrPr-F2-Br, 4-BrI
2768PrPr-F2-Br, 4-MeH
2769PrPr-F2-Br, 4-MeSnMe3
2770PrPr-F2-Br, 4-MeBr
2771PrPr-F2-Br, 4-MeI
2772PrEt-FHH
2773PrEt-FHSnMe3
2774PrEt-FHBr
2775PrEt-FHI
2776PrEt-F4-FH
2777PrEt-F4-FSnMe3
2778PrEt-F4-FBr
2779PrEt-F4-FI
2780PrEt-F5-FH
2781PrEt-F5-FSnMe3
2782PrEt-F5-FBr
2783PrEt-F5-FI
2784PrEt-F4-ClH
2785PrEt-F4-ClSnMe3
2786PrEt-F4-ClBr
2787PrEt-F4-ClI
2788PrEt-F4-BrH
2789PrEt-F4-BrSnMe3
2790PrEt-F4-BrBr
2791PrEt-F4-BrI
2792PrEt-F4-MeH
2793PrEt-F4-MeSnMe3
2794PrEt-F4-MeBr
2795PrEt-F4-MeI
2796PrEt-F4-CF3H
2797PrEt-F4-CF3SnMe3
2798PrEt-F4-CF3Br
2799PrEt-F4-CF3I
2800PrEt-F4-OHH
2801PrEt-F4-OHSnMe3
2802PrEt-F4-OHBr
2803PrEt-F4-OHI
2804PrEt-F4-OMeH
2805PrEt-F4-OMeSnMe3
2806PrEt-F4-OMeBr
2807PrEt-F4-OMeI
2808PrEt-F4-OMeFH
2809PrEt-F4-OMeFSnMe3
2810PrEt-F4-OMeFBr
2811PrEt-F4-OMeFI
2812PrEt-F4-OCF3H
2813PrEt-F4-OCF3SnMe3
2814PrEt-F4-OCF3Br
2815PrEt-F4-OCF3I
2816PrEt-F4-OEtFH
2817PrEt-F4-OEtFSnMe3
2818PrEt-F4-OEtFBr
2819PrEt-F4-OEtFI
2820PrEt-F4-OPrFH
2821PrEt-F4-OPrFSnMe3
2822PrEt-F4-OPrFBr
2823PrEt-F4-OPrFI
2824PrEt-F4-i-PrH
2825PrEt-F4-i-PrSnMe3
2826PrEt-F4-i-PrBr
2827PrEt-F4-i-PrI
2828PrEt-F2-Br, 4-CF3H
2829PrEt-F2-Br, 4-CF3SnMe3
2830PrEt-F2-Br, 4-CF3Br
2831PrEt-F2-Br, 4-CF3I
2832PrEt-F2-CF3, 4-BrH
2833PrEt-F2-CF3, 4-BrSnMe3
2834PrEt-F2-CF3, 4-BrBr
2835PrEt-F2-CF3, 4-BrI
2836PrEt-F2-Br, 4-BrH
2837PrEt-F2-Br, 4-BrSnMe3
2838PrEt-F2-Br, 4-BrBr
2839PrEt-F2-Br, 4-BrI
2840PrEt-F2-Br, 4-MeH
2841PrEt-F2-Br, 4-MeSnMe3
2842PrEt-F2-Br, 4-MeBr
2843PrEt-F2-Br, 4-MeI
2844Pr-FEtHH
2845Pr-FEtHSnMe3
2846Pr-FEtHBr
2847Pr-FEtHI
2848Pr-FEt4-FH
2849Pr-FEt4-FSnMe3
2850Pr-FEt4-FBr
2851Pr-FEt4-FI
2852Pr-FEt5-FH
2853Pr-FEt5-FSnMe3
2854Pr-FEt5-FBr
2855Pr-FEt5-FI
2856Pr-FEt4-ClH
2857Pr-FEt4-ClSnMe3
2858Pr-FEt4-ClBr
2859Pr-FEt4-ClI
2860Pr-FEt4-BrH
2861Pr-FEt4-BrSnMe3
2862Pr-FEt4-BrBr
2863Pr-FEt4-BrI
2864Pr-FEt4-MeH
2865Pr-FEt4-MeSnMe3
2866Pr-FEt4-MeBr
2867Pr-FEt4-MeI
2868Pr-FEt4-CF3H
2869Pr-FEt4-CF3SnMe3
2870Pr-FEt4-CF3Br
2871Pr-FEt4-CF3I
2872Pr-FEt4-OHH
2873Pr-FEt4-OHSnMe3
2874Pr-FEt4-OHBr
2875Pr-FEt4-OHI
2876Pr-FEt4-OMeH
2877Pr-FEt4-OMeSnMe3
2878Pr-FEt4-OMeBr
2879Pr-FEt4-OMeI
2880Pr-FEt4-OMeFH
2881Pr-FEt4-OMeFSnMe3
2882Pr-FEt4-OMeFBr
2883Pr-FEt4-OMeFI
2884Pr-FEt4-OCF3H
2885Pr-FEt4-OCF3SnMe3
2886Pr-FEt4-OCF3Br
2887Pr-FEt4-OCF3I
2888Pr-FEt4-OEtFH
2889Pr-FEt4-OEtFSnMe3
2890Pr-FEt4-OEtFBr
2891Pr-FEt4-OEtFI
2892Pr-FEt4-OPrFH
2893Pr-FEt4-OPrFSnMe3
2894Pr-FEt4-OPrFBr
2895Pr-FEt4-OPrFI
2896Pr-FEt4-i-PrH
2897Pr-FEt4-i-PrSnMe3
2898Pr-FEt4-i-PrBr
2899Pr-FEt4-i-PrI
2900Pr-FEt2-Br, 4-CF3H
2901Pr-FEt2-Br, 4-CF3SnMe3
2902Pr-FEt2-Br, 4-CF3Br
2903Pr-FEt2-Br, 4-CF3I
2904Pr-FEt2-CF3, 4-BrH
2905Pr-FEt2-CF3, 4-BrSnMe3
2906Pr-FEt2-CF3, 4-BrBr
2907Pr-FEt2-CF3, 4-BrI
2908Pr-FEt2-Br, 4-BrH
2909Pr-FEt2-Br, 4-BrSnMe3
2910Pr-FEt2-Br, 4-BrBr
2911Pr-FEt2-Br, 4-BrI
2912Pr-FEt2-Br, 4-MeH
2913Pr-FEt2-Br, 4-MeSnMe3
2914Pr-FEt2-Br, 4-MeBr
2915Pr-FEt2-Br, 4-MeI
2916BuEt-FHH
2917BuEt-FHSnMe3
2918BuEt-FHBr
2919BuEt-FHI
2920BuEt-F4-FH
2921BuEt-F4-FSnMe3
2922BuEt-F4-FBr
2923BuEt-F4-FI
2924BuEt-F5-FH
2925BuEt-F5-FSnMe3
2926BuEt-F5-FBr
2927BuEt-F5-FI
2928BuEt-F4-ClH
2929BuEt-F4-ClSnMe3
2930BuEt-F4-ClBr
2931BuEt-F4-ClI
2932BuEt-F4-BrH
2933BuEt-F4-BrSnMe3
2934BuEt-F4-BrBr
2935BuEt-F4-BrI
2936BuEt-F4-MeH
2937BuEt-F4-MeSnMe3
2938BuEt-F4-MeBr
2939BuEt-F4-MeI
2940BuEt-F4-CF3H
2941BuEt-F4-CF3SnMe3
2942BuEt-F4-CF3Br
2943BuEt-F4-CF3I
2944BuEt-F4-OHH
2945BuEt-F4-OHSnMe3
2946BuEt-F4-OHBr
2947BuEt-F4-OHI
2948BuEt-F4-OMeH
2949BuEt-F4-OMeSnMe3
2950BuEt-F4-OMeBr
2951BuEt-F4-OMeI
2952BuEt-F4-OMeFH
2953BuEt-F4-OMeFSnMe3
2954BuEt-F4-OMeFBr
2955BuEt-F4-OMeFI
2956BuEt-F4-OCF3H
2957BuEt-F4-OCF3SnMe3
2958BuEt-F4-OCF3Br
2959BuEt-F4-OCF3I
2960BuEt-F4-OEtFH
2961BuEt-F4-OEtFSnMe3
2962BuEt-F4-OEtFBr
2963BuEt-F4-OEtFI
2964BuEt-F4-OPrFH
2965BuEt-F4-OPrFSnMe3
2966BuEt-F4-OPrFBr
2967BuEt-F4-OPrFI
2968BuEt-F4-i-PrH
2969BuEt-F4-i-PrSnMe3
2970BuEt-F4-i-PrBr
2971BuEt-F4-i-PrI
2972BuEt-F2-Br, 4-CF3H
2973BuEt-F2-Br, 4-CF3SnMe3
2974BuEt-F2-Br, 4-CF3Br
2975BuEt-F2-Br, 4-CF3I
2976BuEt-F2-CF3, 4-BrH
2977BuEt-F2-CF3, 4-BrSnMe3
2978BuEt-F2-CF3, 4-BrBr
2979BuEt-F2-CF3, 4-BrI
2980BuEt-F2-Br, 4-BrH
2981BuEt-F2-Br, 4-BrSnMe3
2982BuEt-F2-Br, 4-BrBr
2983BuEt-F2-Br, 4-BrI
2984BuEt-F2-Br, 4-MeH
2985BuEt-F2-Br, 4-MeSnMe3
2986BuEt-F2-Br, 4-MeBr
2987BuEt-F2-Br, 4-MeI
2988Bu-FEtHH
2989Bu-FEtHSnMe3
2990Bu-FEtHBr
2991Bu-FEtHI
2992Bu-FEt4-FH
2993Bu-FEt4-FSnMe3
2994Bu-FEt4-FBr
2995Bu-FEt4-FI
2996Bu-FEt5-FH
2997Bu-FEt5-FSnMe3
2998Bu-FEt5-FBr
2999Bu-FEt5-FI
3000Bu-FEt4-ClH
3001Bu-FEt4-ClSnMe3
3002Bu-FEt4-ClBr
3003Bu-FEt4-ClI
3004Bu-FEt4-BrH
3005Bu-FEt4-BrSnMe3
3006Bu-FEt4-BrBr
3007Bu-FEt4-BrI
3008Bu-FEt4-MeH
3009Bu-FEt4-MeSnMe3
3010Bu-FEt4-MeBr
3011Bu-FEt4-MeI
3012Bu-FEt4-CF3H
3013Bu-FEt4-CF3SnMe3
3014Bu-FEt4-CF3Br
3015Bu-FEt4-CF3I
3016Bu-FEt4-OHH
3017Bu-FEt4-OHSnMe3
3018Bu-FEt4-OHBr
3019Bu-FEt4-OHI
3020Bu-FEt4-OMeH
3021Bu-FEt4-OMeSnMe3
3022Bu-FEt4-OMeBr
3023Bu-FEt4-OMeI
3024Bu-FEt4-OMeFH
3025Bu-FEt4-OMeFSnMe3
3026Bu-FEt4-OMeFBr
3027Bu-FEt4-OMeFI
3028Bu-FEt4-OCF3H
3029Bu-FEt4-OCF3SnMe3
3030Bu-FEt4-OCF3Br
3031Bu-FEt4-OCF3I
3032Bu-FEt4-OEtFH
3033Bu-FEt4-OEtFSnMe3
3034Bu-FEt4-OEtFBr
3035Bu-FEt4-OEtFI
3036Bu-FEt4-OPrFH
3037Bu-FEt4-OPrFSnMe3
3038Bu-FEt4-OPrFBr
3039Bu-FEt4-OPrFI
3040Bu-FEt4-i-PrH
3041Bu-FEt4-i-PrSnMe3
3042Bu-FEt4-i-PrBr
3043Bu-FEt4-i-PrI
3044Bu-FEt2-Br, 4-CF3H
3045Bu-FEt2-Br, 4-CF3SnMe3
3046Bu-FEt2-Br, 4-CF3Br
3047Bu-FEt2-Br, 4-CF3I
3048Bu-FEt2-CF3, 4-BrH
3049Bu-FEt2-CF3, 4-BrSnMe3
3050Bu-FEt2-CF3, 4-BrBr
3051Bu-FEt2-CF3, 4-BrI
3052Bu-FEt2-Br, 4-BrH
3053Bu-FEt2-Br, 4-BrSnMe3
3054Bu-FEt2-Br, 4-BrBr
3055Bu-FEt2-Br, 4-BrI
3056Bu-FEt2-Br, 4-MeH
3057Bu-FEt2-Br, 4-MeSnMe3
3058Bu-FEt2-Br, 4-MeBr
3059Bu-FEt2-Br, 4-MeI
3060FCH2—CH═CH—CH2MeHH
3061FCH2—CH═CH—CH2MeHSnMe3
3062FCH2—CH═CH—CH2MeHBr
3063FCH2—CH═CH—CH2MeHI
3064FCH2—CH═CH—CH2Me4-FH
3065FCH2—CH═CH—CH2Me4-FSnMe3
3066FCH2—CH═CH—CH2Me4-FBr
3067FCH2—CH═CH—CH2Me4-FI
3068FCH2—CH═CH—CH2Me5-FH
3069FCH2—CH═CH—CH2Me5-FSnMe3
3070FCH2—CH═CH—CH2Me5-FBr
3071FCH2—CH═CH—CH2Me5-FI
3072FCH2—CH═CH—CH2Me4-ClH
3073FCH2—CH═CH—CH2Me4-ClSnMe3
3074FCH2—CH═CH—CH2Me4-ClBr
3075FCH2—CH═CH—CH2Me4-ClI
3076FCH2—CH═CH—CH2Me4-BrH
3077FCH2—CH═CH—CH2Me4-BrSnMe3
3078FCH2—CH═CH—CH2Me4-BrBr
3079FCH2—CH═CH—CH2Me4-BrI
3080FCH2—CH═CH—CH2Me4-MeH
3081FCH2—CH═CH—CH2Me4-MeSnMe3
3082FCH2—CH═CH—CH2Me4-MeBr
3083FCH2—CH═CH—CH2Me4-MeI
3084FCH2—CH═CH—CH2Me4-CF3H
3085FCH2—CH═CH—CH2Me4-CF3SnMe3
3086FCH2—CH═CH—CH2Me4-CF3Br
3087FCH2—CH═CH—CH2Me4-CF3I
3088FCH2—CH═CH—CH2Me4-OHH
3089FCH2—CH═CH—CH2Me4-OHSnMe3
3090FCH2—CH═CH—CH2Me4-OHBr
3091FCH2—CH═CH—CH2Me4-OHI
3092FCH2—CH═CH—CH2Me4-OMeH
3093FCH2—CH═CH—CH2Me4-OMeSnMe3
3094FCH2—CH═CH—CH2Me4-OMeBr
3095FCH2—CH═CH—CH2Me4-OMeI
3096FCH2—CH═CH—CH2Me4-OMeFH
3097FCH2—CH═CH—CH2Me4-OMeFSnMe3
3098FCH2—CH═CH—CH2Me4-OMeFBr
3099FCH2—CH═CH—CH2Me4-OMeFI
3100FCH2—CH═CH—CH2Me4-OCF3H
3101FCH2—CH═CH—CH2Me4-OCF3SnMe3
3102FCH2—CH═CH—CH2Me4-OCF3Br
3103FCH2—CH═CH—CH2Me4-OCF3I
3104FCH2—CH═CH—CH2Me4-OEtFH
3105FCH2—CH═CH—CH2Me4-OEtFSnMe3
3106FCH2—CH═CH—CH2Me4-OEtFBr
3107FCH2—CH═CH—CH2Me4-OEtFI
3108FCH2—CH═CH—CH2Me4-OPrFH
3109FCH2—CH═CH—CH2Me4-OPrFSnMe3
3110FCH2—CH═CH—CH2Me4-OPrFBr
3111FCH2—CH═CH—CH2Me4-OPrFI
3112FCH2—CH═CH—CH2Me4-i-PrH
3113FCH2—CH═CH—CH2Me4-i-PrSnMe3
3114FCH2—CH═CH—CH2Me4-i-PrBr
3115FCH2—CH═CH—CH2Me4-i-PrI
3116FCH2—CH═CH—CH2Me2-Br, 4-CF3H
3117FCH2—CH═CH—CH2Me2-Br, 4-CF3SnMe3
3118FCH2—CH═CH—CH2Me2-Br, 4-CF3Br
3119FCH2—CH═CH—CH2Me2-Br, 4-CF3I
3120FCH2—CH═CH—CH2Me2-CF3, 4-BrH
3121FCH2—CH═CH—CH2Me2-CF3, 4-BrSnMe3
3122FCH2—CH═CH—CH2Me2-CF3, 4-BrBr
3123FCH2—CH═CH—CH2Me2-CF3, 4-BrI
3124FCH2—CH═CH—CH2Me2-Br, 4-BrH
3125FCH2—CH═CH—CH2Me2-Br, 4-BrSnMe3
3126FCH2—CH═CH—CH2Me2-Br, 4-BrBr
3127FCH2—CH═CH—CH2Me2-Br, 4-BrI
3128FCH2—CH═CH—CH2Me2-Br, 4-MeH
3129FCH2—CH═CH—CH2Me2-Br, 4-MeSnMe3
3130FCH2—CH═CH—CH2Me2-Br, 4-MeBr
3131FCH2—CH═CH—CH2Me2-Br, 4-MeI
3132FCH2—CH═CH—CH2EtHH
3133FCH2—CH═CH—CH2EtHSnMe3
3134FCH2—CH═CH—CH2EtHBr
3135FCH2—CH═CH—CH2EtHI
3136FCH2—CH═CH—CH2Et4-FH
3137FCH2—CH═CH—CH2Et4-FSnMe3
3138FCH2—CH═CH—CH2Et4-FBr
3139FCH2—CH═CH—CH2Et4-FI
3140FCH2—CH═CH—CH2Et5-FH
3141FCH2—CH═CH—CH2Et5-FSnMe3
3142FCH2—CH═CH—CH2Et5-FBr
3143FCH2—CH═CH—CH2Et5-FI
3144FCH2—CH═CH—CH2Et4-ClH
3145FCH2—CH═CH—CH2Et4-ClSnMe3
3146FCH2—CH═CH—CH2Et4-ClBr
3147FCH2—CH═CH—CH2Et4-ClI
3148FCH2—CH═CH—CH2Et4-BrH
3149FCH2—CH═CH—CH2Et4-BrSnMe3
3150FCH2—CH═CH—CH2Et4-BrBr
3151FCH2—CH═CH—CH2Et4-BrI
3152FCH2—CH═CH—CH2Et4-MeH
3153FCH2—CH═CH—CH2Et4-MeSnMe3
3154FCH2—CH═CH—CH2Et4-MeBr
3155FCH2—CH═CH—CH2Et4-MeI
3156FCH2—CH═CH—CH2Et4-CF3H
3157FCH2—CH═CH—CH2Et4-CF3SnMe3
3158FCH2—CH═CH—CH2Et4-CF3Br
3159FCH2—CH═CH—CH2Et4-CF3I
3160FCH2—CH═CH—CH2Et4-OHH
3161FCH2—CH═CH—CH2Et4-OHSnMe3
3162FCH2—CH═CH—CH2Et4-OHBr
3163FCH2—CH═CH—CH2Et4-OHI
3164FCH2—CH═CH—CH2Et4-OMeH
3165FCH2—CH═CH—CH2Et4-OMeSnMe3
3166FCH2—CH═CH—CH2Et4-OMeBr
3167FCH2—CH═CH—CH2Et4-OMeI
3168FCH2—CH═CH—CH2Et4-OMeFH
3169FCH2—CH═CH—CH2Et4-OMeFSnMe3
3170FCH2—CH═CH—CH2Et4-OMeFBr
3171FCH2—CH═CH—CH2Et4-OMeFI
3172FCH2—CH═CH—CH2Et4-OCF3H
3173FCH2—CH═CH—CH2Et4-OCF3SnMe3
3174FCH2—CH═CH—CH2Et4-OCF3Br
3175FCH2—CH═CH—CH2Et4-OCF3I
3176FCH2—CH═CH—CH2Et4-OEtFH
3177FCH2—CH═CH—CH2Et4-OEtFSnMe3
3178FCH2—CH═CH—CH2Et4-OEtFBr
3179FCH2—CH═CH—CH2Et4-OEtFI
3180FCH2—CH═CH—CH2Et4-OPrFH
3181FCH2—CH═CH—CH2Et4-OPrFSnMe3
3182FCH2—CH═CH—CH2Et4-OPrFBr
3183FCH2—CH═CH—CH2Et4-OPrFI
3184FCH2—CH═CH—CH2Et4-i-PrH
3185FCH2—CH═CH—CH2Et4-i-PrSnMe3
3186FCH2—CH═CH—CH2Et4-i-PrBr
3187FCH2—CH═CH—CH2Et4-i-PrI
3188FCH2—CH═CH—CH2Et2-Br, 4-CF3H
3189FCH2—CH═CH—CH2Et2-Br, 4-CF3SnMe3
3190FCH2—CH═CH—CH2Et2-Br, 4-CF3Br
3191FCH2—CH═CH—CH2Et2-Br, 4-CF3I
3192FCH2—CH═CH—CH2Et2-CF3, 4-BrH
3193FCH2—CH═CH—CH2Et2-CF3, 4-BrSnMe3
3194FCH2—CH═CH—CH2Et2-CF3, 4-BrBr
3195FCH2—CH═CH—CH2Et2-CF3, 4-BrI
3196FCH2—CH═CH—CH2Et2-Br, 4-BrH
3197FCH2—CH═CH—CH2Et2-Br, 4-BrSnMe3
3198FCH2—CH═CH—CH2Et2-Br, 4-BrBr
3199FCH2—CH═CH—CH2Et2-Br, 4-BrI
3200FCH2—CH═CH—CH2Et2-Br, 4-MeH
3201FCH2—CH═CH—CH2Et2-Br, 4-MeSnMe3
3202FCH2—CH═CH—CH2Et2-Br, 4-MeBr
3203FCH2—CH═CH—CH2Et2-Br, 4-MeI
3204FCH2—CH═CH—CH2Et-FHH
3205FCH2—CH═CH—CH2Et-FHSnMe3
3206FCH2—CH═CH—CH2Et-FHBr
3207FCH2—CH═CH—CH2Et-FHI
3208FCH2—CH═CH—CH2Et-F4-FH
3209FCH2—CH═CH—CH2Et-F4-FSnMe3
3210FCH2—CH═CH—CH2Et-F4-FBr
3211FCH2—CH═CH—CH2Et-F4-FI
3212FCH2—CH═CH—CH2Et-F5-FH
3213FCH2—CH═CH—CH2Et-F5-FSnMe3
3214FCH2—CH═CH—CH2Et-F5-FBr
3215FCH2—CH═CH—CH2Et-F5-FI
3216FCH2—CH═CH—CH2Et-F4-ClH
3217FCH2—CH═CH—CH2Et-F4-ClSnMe3
3218FCH2—CH═CH—CH2Et-F4-ClBr
3219FCH2—CH═CH—CH2Et-F4-ClI
3220FCH2—CH═CH—CH2Et-F4-BrH
3221FCH2—CH═CH—CH2Et-F4-BrSnMe3
3222FCH2—CH═CH—CH2Et-F4-BrBr
3223FCH2—CH═CH—CH2Et-F4-BrI
3224FCH2—CH═CH—CH2Et-F4-MeH
3225FCH2—CH═CH—CH2Et-F4-MeSnMe3
3226FCH2—CH═CH—CH2Et-F4-MeBr
3227FCH2—CH═CH—CH2Et-F4-MeI
3228FCH2—CH═CH—CH2Et-F4-CF3H
3229FCH2—CH═CH—CH2Et-F4-CF3SnMe3
3230FCH2—CH═CH—CH2Et-F4-CF3Br
3231FCH2—CH═CH—CH2Et-F4-CF3I
3232FCH2—CH═CH—CH2Et-F4-OHH
3233FCH2—CH═CH—CH2Et-F4-OHSnMe3
3234FCH2—CH═CH—CH2Et-F4-OHBr
3235FCH2—CH═CH—CH2Et-F4-OHI
3236FCH2—CH═CH—CH2Et-F4-OMeH
3237FCH2—CH═CH—CH2Et-F4-OMeSnMe3
3238FCH2—CH═CH—CH2Et-F4-OMeBr
3239FCH2—CH═CH—CH2Et-F4-OMeI
3240FCH2—CH═CH—CH2Et-F4-OMeFH
3241FCH2—CH═CH—CH2Et-F4-OMeFSnMe3
3242FCH2—CH═CH—CH2Et-F4-OMeFBr
3243FCH2—CH═CH—CH2Et-F4-OMeFI
3244FCH2—CH═CH—CH2Et-F4-OCF3H
3245FCH2—CH═CH—CH2Et-F4-OCF3SnMe3
3246FCH2—CH═CH—CH2Et-F4-OCF3Br
3247FCH2—CH═CH—CH2Et-F4-OCF3I
3248FCH2—CH═CH—CH2Et-F4-OEtFH
3249FCH2—CH═CH—CH2Et-F4-OEtFSnMe3
3250FCH2—CH═CH—CH2Et-F4-OEtFBr
3251FCH2—CH═CH—CH2Et-F4-OEtFI
3252FCH2—CH═CH—CH2Et-F4-OPrFH
3253FCH2—CH═CH—CH2Et-F4-OPrFSnMe3
3254FCH2—CH═CH—CH2Et-F4-OPrFBr
3255FCH2—CH═CH—CH2Et-F4-OPrFI
3256FCH2—CH═CH—CH2Et-F4-i-PrH
3257FCH2—CH═CH—CH2Et-F4-i-PrSnMe3
3258FCH2—CH═CH—CH2Et-F4-i-PrBr
3259FCH2—CH═CH—CH2Et-F4-i-PrI
3260FCH2—CH═CH—CH2Et-F2-Br, 4-CF3H
3261FCH2—CH═CH—CH2Et-F2-Br, 4-CF3SnMe3
3262FCH2—CH═CH—CH2Et-F2-Br, 4-CF3Br
3263FCH2—CH═CH—CH2Et-F2-Br, 4-CF3I
3264FCH2—CH═CH—CH2Et-F2-CF3, 4-BrH
3265FCH2—CH═CH—CH2Et-F2-CF3, 4-BrSnMe3
3266FCH2—CH═CH—CH2Et-F2-CF3, 4-BrBr
3267FCH2—CH═CH—CH2Et-F2-CF3, 4-BrI
3268FCH2—CH═CH—CH2Et-F2-Br, 4-BrH
3269FCH2—CH═CH—CH2Et-F2-Br, 4-BrSnMe3
3270FCH2—CH═CH—CH2Et-F2-Br, 4-BrBr
3271FCH2—CH═CH—CH2Et-F2-Br, 4-BrI
3272FCH2—CH═CH—CH2Et-F2-Br, 4-MeH
3273FCH2—CH═CH—CH2Et-F2-Br, 4-MeSnMe3
3274FCH2—CH═CH—CH2Et-F2-Br, 4-MeBr
3275FCH2—CH═CH—CH2Et-F2-Br, 4-MeI

TABLE 3
Substituent list for compounds of general structure VIII.
VIII
embedded image
Compound #R1 =R2 =R5 =X2 =
3276BuEtHH
3277BuEtHSnMe3
3278BuEtHBr
3279BuEtHI
3280BuEt2-FH
3281BuEt2-FSnMe3
3282BuEt2-FBr
3283BuEt2-FI
3284BuEt2-ClH
3285BuEt2-ClSnMe3
3286BuEt2-ClBr
3287BuEt2-ClI
3288BuEt2-BrH
3289BuEt2-BrSnMe3
3290BuEt2-BrBr
3291BuEt2-BrI
3292BuEt2-MeH
3293BuEt2-MeSnMe3
3294BuEt2-MeBr
3295BuEt2-MeI
3296BuEt2-EtH
3297BuEt2-EtSnMe3
3298BuEt2-EtBr
3299BuEt2-EtI
3300BuEt2-Me, 6-MeH
3301BuEt2-Me, 6-MeSnMe3
3302BuEt2-Me, 6-MeBr
3303BuEt2-Me, 6-MeI
3304BuEt2-OHH
3305BuEt2-OHSnMe3
3306BuEt2-OHBr
3307BuEt2-OHI
3308BuEt2-OMeH
3309BuEt2-OMeSnMe3
3310BuEt2-OMeBr
3311BuEt2-OMeI
3312BuEt2-OMeFH
3313BuEt2-OMeFSnMe3
3314BuEt2-OMeFBr
3315BuEt2-OMeFI
3316BuEt2-OCF3H
3317BuEt2-OCF3SnMe3
3318BuEt2-OCF3Br
3319BuEt2-OCF3I
3320BuEt2-OEtFH
3321BuEt2-OEtFSnMe3
3322BuEt2-OEtFBr
3323BuEt2-OEtFI
3324BuEt2-OPrFH
3325BuEt2-OPrFSnMe3
3326BuEt2-OPrFBr
3327BuEt2-OPrFI
3328BuEt2-CF3H
3329BuEt2-CF3SnMe3
3330BuEt2-CF3Br
3331BuEt2-CF3I
3332BuEt2-Br, 6-CF3H
3333BuEt2-Br, 6-CF3SnMe3
3334BuEt2-Br, 6-CF3Br
3335BuEt2-Br, 6-CF3I
3336BuEt2-Br, 6-BrH
3337BuEt2-Br, 6-BrSnMe3
3338BuEt2-Br, 6-BrBr
3339BuEt2-Br, 6-BrI
3340PrPrHH
3341PrPrHSnMe3
3342PrPrHBr
3343PrPrHI
3344PrPr2-FH
3345PrPr2-FSnMe3
3346PrPr2-FBr
3347PrPr2-FI
3348PrPr2-ClH
3349PrPr2-ClSnMe3
3350PrPr2-ClBr
3351PrPr2-ClI
3352PrPr2-BrH
3353PrPr2-BrSnMe3
3354PrPr2-BrBr
3355PrPr2-BrI
3356PrPr2-MeH
3357PrPr2-MeSnMe3
3358PrPr2-MeBr
3359PrPr2-MeI
3360PrPr2-EtH
3361PrPr2-EtSnMe3
3362PrPr2-EtBr
3363PrPr2-EtI
3364PrPr2-Me, 6-MeH
3365PrPr2-Me, 6-MeSnMe3
3366PrPr2-Me, 6-MeBr
3367PrPr2-Me, 6-MeI
3368PrPr2-OHH
3369PrPr2-OHSnMe3
3370PrPr2-OHBr
3371PrPr2-OHI
3372PrPr2-OMeH
3373PrPr2-OMeSnMe3
3374PrPr2-OMeBr
3375PrPr2-OMeI
3376PrPr2-OMeFH
3377PrPr2-OMeFSnMe3
3378PrPr2-OMeFBr
3379PrPr2-OMeFI
3380PrPr2-OCF3H
3381PrPr2-OCF3SnMe3
3382PrPr2-OCF3Br
3383PrPr2-OCF3I
3384PrPr2-OEtFH
3385PrPr2-OEtFSnMe3
3386PrPr2-OEtFBr
3387PrPr2-OEtFI
3388PrPr2-OPrFH
3389PrPr2-OPrFSnMe3
3390PrPr2-OPrFBr
3391PrPr2-OPrFI
3392PrPr2-CF3H
3393PrPr2-CF3SnMe3
3394PrPr2-CF3Br
3395PrPr2-CF3I
3396PrPr2-Br, 6-CF3H
3397PrPr2-Br, 6-CF3SnMe3
3398PrPr2-Br, 6-CF3Br
3399PrPr2-Br, 6-CF3I
3400PrPr2-Br, 6-BrH
3401PrPr2-Br, 6-BrSnMe3
3402PrPr2-Br, 6-BrBr
3403PrPr2-Br, 6-BrI
3404PrPr-FHH
3405PrPr-FHSnMe3
3406PrPr-FHBr
3407PrPr-FHI
3408PrPr-F2-FH
3409PrPr-F2-FSnMe3
3410PrPr-F2-FBr
3411PrPr-F2-FI
3412PrPr-F2-ClH
3413PrPr-F2-ClSnMe3
3414PrPr-F2-ClBr
3415PrPr-F2-ClI
3416PrPr-F2-BrH
3417PrPr-F2-BrSnMe3
3418PrPr-F2-BrBr
3419PrPr-F2-BrI
3420PrPr-F2-MeH
3421PrPr-F2-MeSnMe3
3422PrPr-F2-MeBr
3423PrPr-F2-MeI
3424PrPr-F2-EtH
3425PrPr-F2-EtSnMe3
3426PrPr-F2-EtBr
3427PrPr-F2-EtI
3428PrPr-F2-Me, 6-MeH
3429PrPr-F2-Me, 6-MeSnMe3
3430PrPr-F2-Me, 6-MeBr
3431PrPr-F2-Me, 6-MeI
3432PrPr-F2-OHH
3433PrPr-F2-OHSnMe3
3434PrPr-F2-OHBr
3435PrPr-F2-OHI
3436PrPr-F2-OMeH
3437PrPr-F2-OMeSnMe3
3438PrPr-F2-OMeBr
3439PrPr-F2-OMeI
3440PrPr-F2-OMeFH
3441PrPr-F2-OMeFSnMe3
3442PrPr-F2-OMeFBr
3443PrPr-F2-OMeFI
3444PrPr-F2-OCF3H
3445PrPr-F2-OCF3SnMe3
3446PrPr-F2-OCF3Br
3447PrPr-F2-OCF3I
3448PrPr-F2-OEtFH
3449PrPr-F2-OEtFSnMe3
3450PrPr-F2-OEtFBr
3451PrPr-F2-OEtFI
3452PrPr-F2-OPrFH
3453PrPr-F2-OPrFSnMe3
3454PrPr-F2-OPrFBr
3455PrPr-F2-OPrFI
3456PrPr-F2-CF3H
3457PrPr-F2-CF3SnMe3
3458PrPr-F2-CF3Br
3459PrPr-F2-CF3I
3460PrPr-F2-Br, 6-CF3H
3461PrPr-F2-Br, 6-CF3SnMe3
3462PrPr-F2-Br, 6-CF3Br
3463PrPr-F2-Br, 6-CF3I
3464PrPr-F2-Br, 6-BrH
3465PrPr-F2-Br, 6-BrSnMe3
3466PrPr-F2-Br, 6-BrBr
3467PrPr-F2-Br, 6-BrI
3468PrEt-FHH
3469PrEt-FHSnMe3
3470PrEt-FHBr
3471PrEt-FHI
3472PrEt-F2-FH
3473PrEt-F2-FSnMe3
3474PrEt-F2-FBr
3475PrEt-F2-FI
3476PrEt-F2-ClH
3477PrEt-F2-ClSnMe3
3478PrEt-F2-ClBr
3479PrEt-F2-ClI
3480PrEt-F2-BrH
3481PrEt-F2-BrSnMe3
3482PrEt-F2-BrBr
3483PrEt-F2-BrI
3484PrEt-F2-MeH
3485PrEt-F2-MeSnMe3
3486PrEt-F2-MeBr
3487PrEt-F2-MeI
3488PrEt-F2-EtH
3489PrEt-F2-EtSnMe3
3490PrEt-F2-EtBr
3491PrEt-F2-EtI
3492PrEt-F2-Me, 6-MeH
3493PrEt-F2-Me, 6-MeSnMe3
3494PrEt-F2-Me, 6-MeBr
3495PrEt-F2-Me, 6-MeI
3496PrEt-F2-OHH
3497PrEt-F2-OHSnMe3
3498PrEt-F2-OHBr
3499PrEt-F2-OHI
3500PrEt-F2-OMeH
3501PrEt-F2-OMeSnMe3
3502PrEt-F2-OMeBr
3503PrEt-F2-OMeI
3504PrEt-F2-OMeFH
3505PrEt-F2-OMeFSnMe3
3506PrEt-F2-OMeFBr
3507PrEt-F2-OMeFI
3508PrEt-F2-OCF3H
3509PrEt-F2-OCF3SnMe3
3510PrEt-F2-OCF3Br
3511PrEt-F2-OCF3I
3512PrEt-F2-OEtFH
3513PrEt-F2-OEtFSnMe3
3514PrEt-F2-OEtFBr
3515PrEt-F2-OEtFI
3516PrEt-F2-OPrFH
3517PrEt-F2-OPrFSnMe3
3518PrEt-F2-OPrFBr
3519PrEt-F2-OPrFI
3520PrEt-F2-CF3H
3521PrEt-F2-CF3SnMe3
3522PrEt-F2-CF3Br
3523PrEt-F2-CF3I
3524PrEt-F2-Br, 6-CF3H
3525PrEt-F2-Br, 6-CF3SnMe3
3526PrEt-F2-Br, 6-CF3Br
3527PrEt-F2-Br, 6-CF3I
3528PrEt-F2-Br, 6-BrH
3529PrEt-F2-Br, 6-BrSnMe3
3530PrEt-F2-Br, 6-BrBr
3531PrEt-F2-Br, 6-BrI
3532Pr-FEtHH
3533Pr-FEtHSnMe3
3534Pr-FEtHBr
3535Pr-FEtHI
3536Pr-FEt2-FH
3537Pr-FEt2-FSnMe3
3538Pr-FEt2-FBr
3539Pr-FEt2-FI
3540Pr-FEt2-ClH
3541Pr-FEt2-ClSnMe3
3542Pr-FEt2-ClBr
3543Pr-FEt2-ClI
3544Pr-FEt2-BrH
3545Pr-FEt2-BrSnMe3
3546Pr-FEt2-BrBr
3547Pr-FEt2-BrI
3548Pr-FEt2-MeH
3549Pr-FEt2-MeSnMe3
3550Pr-FEt2-MeBr
3551Pr-FEt2-MeI
3552Pr-FEt2-EtH
3553Pr-FEt2-EtSnMe3
3554Pr-FEt2-EtBr
3555Pr-FEt2-EtI
3556Pr-FEt2-Me, 6-MeH
3557Pr-FEt2-Me, 6-MeSnMe3
3558Pr-FEt2-Me, 6-MeBr
3559Pr-FEt2-Me, 6-MeI
3560Pr-FEt2-OHH
3561Pr-FEt2-OHSnMe3
3562Pr-FEt2-OHBr
3563Pr-FEt2-OHI
3564Pr-FEt2-OMeH
3565Pr-FEt2-OMeSnMe3
3566Pr-FEt2-OMeBr
3567Pr-FEt2-OMeI
3568Pr-FEt2-OMeFH
3569Pr-FEt2-OMeFSnMe3
3570Pr-FEt2-OMeFBr
3571Pr-FEt2-OMeFI
3572Pr-FEt2-OCF3H
3573Pr-FEt2-OCF3SnMe3
3574Pr-FEt2-OCF3Br
3575Pr-FEt2-OCF3I
3576Pr-FEt2-OEtFH
3577Pr-FEt2-OEtFSnMe3
3578Pr-FEt2-OEtFBr
3579Pr-FEt2-OEtFI
3580Pr-FEt2-OPrFH
3581Pr-FEt2-OPrFSnMe3
3582Pr-FEt2-OPrFBr
3583Pr-FEt2-OPrFI
3584Pr-FEt2-CF3H
3585Pr-FEt2-CF3SnMe3
3586Pr-FEt2-CF3Br
3587Pr-FEt2-CF3I
3588Pr-FEt2-Br, 6-CF3H
3589Pr-FEt2-Br, 6-CF3SnMe3
3590Pr-FEt2-Br, 6-CF3Br
3591Pr-FEt2-Br, 6-CF3I
3592Pr-FEt2-Br, 6-BrH
3593Pr-FEt2-Br, 6-BrSnMe3
3594Pr-FEt2-Br, 6-BrBr
3595Pr-FEt2-Br, 6-BrI
3596BuEt-FHH
3597BuEt-FHSnMe3
3598BuEt-FHBr
3599BuEt-FHI
3600BuEt-F2-FH
3601BuEt-F2-FSnMe3
3602BuEt-F2-FBr
3603BuEt-F2-FI
3604BuEt-F2-ClH
3605BuEt-F2-ClSnMe3
3606BuEt-F2-ClBr
3607BuEt-F2-ClI
3608BuEt-F2-BrH
3609BuEt-F2-BrSnMe3
3610BuEt-F2-BrBr
3611BuEt-F2-BrI
3612BuEt-F2-MeH
3613BuEt-F2-MeSnMe3
3614BuEt-F2-MeBr
3615BuEt-F2-MeI
3616BuEt-F2-EtH
3617BuEt-F2-EtSnMe3
3618BuEt-F2-EtBr
3619BuEt-F2-EtI
3620BuEt-F2-Me, 6-MeH
3621BuEt-F2-Me, 6-MeSnMe3
3622BuEt-F2-Me, 6-MeBr
3623BuEt-F2-Me, 6-MeI
3624BuEt-F2-OHH
3625BuEt-F2-OHSnMe3
3626BuEt-F2-OHBr
3627BuEt-F2-OHI
3628BuEt-F2-OMeH
3629BuEt-F2-OMeSnMe3
3630BuEt-F2-OMeBr
3631BuEt-F2-OMeI
3632BuEt-F2-OMeFH
3633BuEt-F2-OMeFSnMe3
3634BuEt-F2-OMeFBr
3635BuEt-F2-OMeFI
3636BuEt-F2-OCF3H
3637BuEt-F2-OCF3SnMe3
3638BuEt-F2-OCF3Br
3639BuEt-F2-OCF3I
3640BuEt-F2-OEtFH
3641BuEt-F2-OEtFSnMe3
3642BuEt-F2-OEtFBr
3643BuEt-F2-OEtFI
3644BuEt-F2-OPrFH
3645BuEt-F2-OPrFSnMe3
3646BuEt-F2-OPrFBr
3647BuEt-F2-OPrFI
3648BuEt-F2-CF3H
3649BuEt-F2-CF3SnMe3
3650BuEt-F2-CF3Br
3651BuEt-F2-CF3I
3652BuEt-F2-Br, 6-CF3H
3653BuEt-F2-Br, 6-CF3SnMe3
3654BuEt-F2-Br, 6-CF3Br
3655BuEt-F2-Br, 6-CF3I
3656BuEt-F2-Br, 6-BrH
3657BuEt-F2-Br, 6-BrSnMe3
3658BuEt-F2-Br, 6-BrBr
3659BuEt-F2-Br, 6-BrI
3660Bu-FEtHH
3661Bu-FEtHSnMe3
3662Bu-FEtHBr
3663Bu-FEtHI
3664Bu-FEt2-FH
3665Bu-FEt2-FSnMe3
3666Bu-FEt2-FBr
3667Bu-FEt2-FI
3668Bu-FEt2-ClH
3669Bu-FEt2-ClSnMe3
3670Bu-FEt2-ClBr
3671Bu-FEt2-ClI
3672Bu-FEt2-BrH
3673Bu-FEt2-BrSnMe3
3674Bu-FEt2-BrBr
3675Bu-FEt2-BrI
3676Bu-FEt2-MeH
3677Bu-FEt2-MeSnMe3
3678Bu-FEt2-MeBr
3679Bu-FEt2-MeI
3680Bu-FEt2-EtH
3681Bu-FEt2-EtSnMe3
3682Bu-FEt2-EtBr
3683Bu-FEt2-EtI
3684Bu-FEt2-Me, 6-MeH
3685Bu-FEt2-Me, 6-MeSnMe3
3686Bu-FEt2-Me, 6-MeBr
3687Bu-FEt2-Me, 6-MeI
3688Bu-FEt2-OHH
3689Bu-FEt2-OHSnMe3
3690Bu-FEt2-OHBr
3691Bu-FEt2-OHI
3692Bu-FEt2-OMeH
3693Bu-FEt2-OMeSnMe3
3694Bu-FEt2-OMeBr
3695Bu-FEt2-OMeI
3696Bu-FEt2-OMeFH
3697Bu-FEt2-OMeFSnMe3
3698Bu-FEt2-OMeFBr
3699Bu-FEt2-OMeFI
3700Bu-FEt2-OCF3H
3701Bu-FEt2-OCF3SnMe3
3702Bu-FEt2-OCF3Br
3703Bu-FEt2-OCF3I
3704Bu-FEt2-OEtFH
3705Bu-FEt2-OEtFSnMe3
3706Bu-FEt2-OEtFBr
3707Bu-FEt2-OEtFI
3708Bu-FEt2-OPrFH
3709Bu-FEt2-OPrFSnMe3
3710Bu-FEt2-OPrFBr
3711Bu-FEt2-OPrFI
3712Bu-FEt2-CF3H
3713Bu-FEt2-CF3SnMe3
3714Bu-FEt2-CF3Br
3715Bu-FEt2-CF3I
3716Bu-FEt2-Br, 6-CF3H
3717Bu-FEt2-Br, 6-CF3SnMe3
3718Bu-FEt2-Br, 6-CF3Br
3719Bu-FEt2-Br, 6-CF3I
3720Bu-FEt2-Br, 6-BrH
3721Bu-FEt2-Br, 6-BrSnMe3
3722Bu-FEt2-Br, 6-BrBr
3723Bu-FEt2-Br, 6-BrI
3724FCH2—CH═CH—CH2MeHH
3725FCH2—CH═CH—CH2MeHSnMe3
3726FCH2—CH═CH—CH2MeHBr
3727FCH2—CH═CH—CH2MeHI
3728FCH2—CH═CH—CH2Me2-FH
3729FCH2—CH═CH—CH2Me2-FSnMe3
3730FCH2—CH═CH—CH2Me2-FBr
3731FCH2—CH═CH—CH2Me2-FI
3732FCH2—CH═CH—CH2Me2-ClH
3733FCH2—CH═CH—CH2Me2-ClSnMe3
3734FCH2—CH═CH—CH2Me2-ClBr
3735FCH2—CH═CH—CH2Me2-ClI
3736FCH2—CH═CH—CH2Me2-BrH
3737FCH2—CH═CH—CH2Me2-BrSnMe3
3738FCH2—CH═CH—CH2Me2-BrBr
3739FCH2—CH═CH—CH2Me2-BrI
3740FCH2—CH═CH—CH2Me2-MeH
3741FCH2—CH═CH—CH2Me2-MeSnMe3
3742FCH2—CH═CH—CH2Me2-MeBr
3743FCH2—CH═CH—CH2Me2-MeI
3744FCH2—CH═CH—CH2Me2-EtH
3745FCH2—CH═CH—CH2Me2-EtSnMe3
3746FCH2—CH═CH—CH2Me2-EtBr
3747FCH2—CH═CH—CH2Me2-EtI
3748FCH2—CH═CH—CH2Me2-Me, 6-MeH
3749FCH2—CH═CH—CH2Me2-Me, 6-MeSnMe3
3750FCH2—CH═CH—CH2Me2-Me, 6-MeBr
3751FCH2—CH═CH—CH2Me2-Me, 6-MeI
3752FCH2—CH═CH—CH2Me2-OHH
3753FCH2—CH═CH—CH2Me2-OHSnMe3
3754FCH2—CH═CH—CH2Me2-OHBr
3755FCH2—CH═CH—CH2Me2-OHI
3756FCH2—CH═CH—CH2Me2-OMeH
3757FCH2—CH═CH—CH2Me2-OMeSnMe3
3758FCH2—CH═CH—CH2Me2-OMeBr
3759FCH2—CH═CH—CH2Me2-OMeI
3760FCH2—CH═CH—CH2Me2-OMeFH
3761FCH2—CH═CH—CH2Me2-OMeFSnMe3
3762FCH2—CH═CH—CH2Me2-OMeFBr
3763FCH2—CH═CH—CH2Me2-OMeFI
3764FCH2—CH═CH—CH2Me2-OCF3H
3765FCH2—CH═CH—CH2Me2-OCF3SnMe3
3766FCH2—CH═CH—CH2Me2-OCF3Br
3767FCH2—CH═CH—CH2Me2-OCF3I
3768FCH2—CH═CH—CH2Me2-OEtFH
3769FCH2—CH═CH—CH2Me2-OEtFSnMe3
3770FCH2—CH═CH—CH2Me2-OEtFBr
3771FCH2—CH═CH—CH2Me2-OEtFI
3772FCH2—CH═CH—CH2Me2-OPrFH
3773FCH2—CH═CH—CH2Me2-OPrFSnMe3
3774FCH2—CH═CH—CH2Me2-OPrFBr
3775FCH2—CH═CH—CH2Me2-OPrFI
3776FCH2—CH═CH—CH2Me2-CF3H
3777FCH2—CH═CH—CH2Me2-CF3SnMe3
3778FCH2—CH═CH—CH2Me2-CF3Br
3779FCH2—CH═CH—CH2Me2-CF3I
3780FCH2—CH═CH—CH2Me2-Br, 6-CF3H
3781FCH2—CH═CH—CH2Me2-Br, 6-CF3SnMe3
3782FCH2—CH═CH—CH2Me2-Br, 6-CF3Br
3783FCH2—CH═CH—CH2Me2-Br, 6-CF3I
3784FCH2—CH═CH—CH2Me2-Br, 6-BrH
3785FCH2—CH═CH—CH2Me2-Br, 6-BrSnMe3
3786FCH2—CH═CH—CH2Me2-Br, 6-BrBr
3787FCH2—CH═CH—CH2Me2-Br, 6-BrI
3788FCH2—CH═CH—CH2EtHH
3789FCH2—CH═CH—CH2EtHSnMe3
3790FCH2—CH═CH—CH2EtHBr
3791FCH2—CH═CH—CH2EtHI
3792FCH2—CH═CH—CH2Et2-FH
3793FCH2—CH═CH—CH2Et2-FSnMe3
3794FCH2—CH═CH—CH2Et2-FBr
3795FCH2—CH═CH—CH2Et2-FI
3796FCH2—CH═CH—CH2Et2-ClH
3797FCH2—CH═CH—CH2Et2-ClSnMe3
3798FCH2—CH═CH—CH2Et2-ClBr
3799FCH2—CH═CH—CH2Et2-ClI
3800FCH2—CH═CH—CH2Et2-BrH
3801FCH2—CH═CH—CH2Et2-BrSnMe3
3802FCH2—CH═CH—CH2Et2-BrBr
3803FCH2—CH═CH—CH2Et2-BrI
3804FCH2—CH═CH—CH2Et2-MeH
3805FCH2—CH═CH—CH2Et2-MeSnMe3
3806FCH2—CH═CH—CH2Et2-MeBr
3807FCH2—CH═CH—CH2Et2-MeI
3808FCH2—CH═CH—CH2Et2-EtH
3809FCH2—CH═CH—CH2Et2-EtSnMe3
3810FCH2—CH═CH—CH2Et2-EtBr
3811FCH2—CH═CH—CH2Et2-EtI
3812FCH2—CH═CH—CH2Et2-Me, 6-MeH
3813FCH2—CH═CH—CH2Et2-Me, 6-MeSnMe3
3814FCH2—CH═CH—CH2Et2-Me, 6-MeBr
3815FCH2—CH═CH—CH2Et2-Me, 6-MeI
3816FCH2—CH═CH—CH2Et2-OHH
3817FCH2—CH═CH—CH2Et2-OHSnMe3
3818FCH2—CH═CH—CH2Et2-OHBr
3819FCH2—CH═CH—CH2Et2-OHI
3820FCH2—CH═CH—CH2Et2-OMeH
3821FCH2—CH═CH—CH2Et2-OMeSnMe3
3822FCH2—CH═CH—CH2Et2-OMeBr
3823FCH2—CH═CH—CH2Et2-OMeI
3824FCH2—CH═CH—CH2Et2-OMeFH
3825FCH2—CH═CH—CH2Et2-OMeFSnMe3
3826FCH2—CH═CH—CH2Et2-OMeFBr
3827FCH2—CH═CH—CH2Et2-OMeFI
3828FCH2—CH═CH—CH2Et2-OCF3H
3829FCH2—CH═CH—CH2Et2-OCF3SnMe3
3830FCH2—CH═CH—CH2Et2-OCF3Br
3831FCH2—CH═CH—CH2Et2-OCF3I
3832FCH2—CH═CH—CH2Et2-OEtFH
3833FCH2—CH═CH—CH2Et2-OEtFSnMe3
3834FCH2—CH═CH—CH2Et2-OEtFBr
3835FCH2—CH═CH—CH2Et2-OEtFI
3836FCH2—CH═CH—CH2Et2-OPrFH
3837FCH2—CH═CH—CH2Et2-OPrFSnMe3
3838FCH2—CH═CH—CH2Et2-OPrFBr
3839FCH2—CH═CH—CH2Et2-OPrFI
3840FCH2—CH═CH—CH2Et2-CF3H
3841FCH2—CH═CH—CH2Et2-CF3SnMe3
3842FCH2—CH═CH—CH2Et2-CF3Br
3843FCH2—CH═CH—CH2Et2-CF3I
3844FCH2—CH═CH—CH2Et2-Br, 6-CF3H
3845FCH2—CH═CH—CH2Et2-Br, 6-CF3SnMe3
3846FCH2—CH═CH—CH2Et2-Br, 6-CF3Br
3847FCH2—CH═CH—CH2Et2-Br, 6-CF3I
3848FCH2—CH═CH—CH2Et2-Br, 6-BrH
3849FCH2—CH═CH—CH2Et2-Br, 6-BrSnMe3
3850FCH2—CH═CH—CH2Et2-Br, 6-BrBr
3851FCH2—CH═CH—CH2Et2-Br, 6-BrI
3852FCH2—CH═CH—CH2Et-FHH
3853FCH2—CH═CH—CH2Et-FHSnMe3
3854FCH2—CH═CH—CH2Et-FHBr
3855FCH2—CH═CH—CH2Et-FHI
3856FCH2—CH═CH—CH2Et-F2-FH
3857FCH2—CH═CH—CH2Et-F2-FSnMe3
3858FCH2—CH═CH—CH2Et-F2-FBr
3859FCH2—CH═CH—CH2Et-F2-FI
3860FCH2—CH═CH—CH2Et-F2-ClH
3861FCH2—CH═CH—CH2Et-F2-ClSnMe3
3862FCH2—CH═CH—CH2Et-F2-ClBr
3863FCH2—CH═CH—CH2Et-F2-ClI
3864FCH2—CH═CH—CH2Et-F2-BrH
3865FCH2—CH═CH—CH2Et-F2-BrSnMe3
3866FCH2—CH═CH—CH2Et-F2-BrBr
3867FCH2—CH═CH—CH2Et-F2-BrI
3868FCH2—CH═CH—CH2Et-F2-MeH
3869FCH2—CH═CH—CH2Et-F2-MeSnMe3
3870FCH2—CH═CH—CH2Et-F2-MeBr
3871FCH2—CH═CH—CH2Et-F2-MeI
3872FCH2—CH═CH—CH2Et-F2-EtH
3873FCH2—CH═CH—CH2Et-F2-EtSnMe3
3874FCH2—CH═CH—CH2Et-F2-EtBr
3875FCH2—CH═CH—CH2Et-F2-EtI
3876FCH2—CH═CH—CH2Et-F2-Me, 6-MeH
3877FCH2—CH═CH—CH2Et-F2-Me, 6-MeSnMe3
3878FCH2—CH═CH—CH2Et-F2-Me, 6-MeBr
3879FCH2—CH═CH—CH2Et-F2-Me, 6-MeI
3880FCH2—CH═CH—CH2Et-F2-OHH
3881FCH2—CH═CH—CH2Et-F2-OHSnMe3
3882FCH2—CH═CH—CH2Et-F2-OHBr
3883FCH2—CH═CH—CH2Et-F2-OHI
3884FCH2—CH═CH—CH2Et-F2-OMeH
3885FCH2—CH═CH—CH2Et-F2-OMeSnMe3
3886FCH2—CH═CH—CH2Et-F2-OMeBr
3887FCH2—CH═CH—CH2Et-F2-OMeI
3888FCH2—CH═CH—CH2Et-F2-OMeFH
3889FCH2—CH═CH—CH2Et-F2-OMeFSnMe3
3890FCH2—CH═CH—CH2Et-F2-OMeFBr
3891FCH2—CH═CH—CH2Et-F2-OMeFI
3892FCH2—CH═CH—CH2Et-F2-OCF3H
3893FCH2—CH═CH—CH2Et-F2-OCF3SnMe3
3894FCH2—CH═CH—CH2Et-F2-OCF3Br
3895FCH2—CH═CH—CH2Et-F2-OCF3I
3896FCH2—CH═CH—CH2Et-F2-OEtFH
3897FCH2—CH═CH—CH2Et-F2-OEtFSnMe3
3898FCH2—CH═CH—CH2Et-F2-OEtFBr
3899FCH2—CH═CH—CH2Et-F2-OEtFI
3900FCH2—CH═CH—CH2Et-F2-OPrFH
3901FCH2—CH═CH—CH2Et-F2-OPrFSnMe3
3902FCH2—CH═CH—CH2Et-F2-OPrFBr
3903FCH2—CH═CH—CH2Et-F2-OPrFI
3904FCH2—CH═CH—CH2Et-F2-CF3H
3905FCH2—CH═CH—CH2Et-F2-CF3SnMe3
3906FCH2—CH═CH—CH2Et-F2-CF3Br
3907FCH2—CH═CH—CH2Et-F2-CF3I
3908FCH2—CH═CH—CH2Et-F2-Br, 6-CF3H
3909FCH2—CH═CH—CH2Et-F2-Br, 6-CF3SnMe3
3910FCH2—CH═CH—CH2Et-F2-Br, 6-CF3Br
3911FCH2—CH═CH—CH2Et-F2-Br, 6-CF3I
3912FCH2—CH═CH—CH2Et-F2-Br, 6-BrH
3913FCH2—CH═CH—CH2Et-F2-Br, 6-BrSnMe3
3914FCH2—CH═CH—CH2Et-F2-Br, 6-BrBr
3915FCH2—CH═CH—CH2Et-F2-Br, 6-BrI

TABLE 4
Substituents list for compounds of general structure IX.
IXa
embedded image
IXb
embedded image
Compound #R1 =R2 =R4 =n =
3916BuEtH1
3917BuEtH2
3918BuEtH3
3919BuEt4-F1
3920BuEt4-F2
3921BuEt4-F3
3922BuEt5-F1
3923BuEt5-F2
3924BuEt5-F3
3925BuEt4-Cl1
3926BuEt4-Cl2
3927BuEt4-Cl3
3928BuEt4-Br1
3929BuEt4-Br2
3930BuEt4-Br3
3931BuEt4-Me1
3932BuEt4-Me2
3933BuEt4-Me3
3934BuEt4-CF31
3935BuEt4-CF32
3936BuEt4-CF33
3937BuEt4-OH1
3938BuEt4-OH2
3939BuEt4-OH3
3940BuEt4-OMe1
3941BuEt4-OMe2
3942BuEt4-OMe3
3943BuEt4-OMeF1
3944BuEt4-OMeF2
3945BuEt4-OMeF3
3946BuEt4-OCF31
3947BuEt4-OCF32
3948BuEt4-OCF33
3949BuEt4-OEtF1
3950BuEt4-OEtF2
3951BuEt4-OEtF3
3952BuEt4-OPrF1
3953BuEt4-OPrF2
3954BuEt4-OPrF3
3955BuEt4-i-Pr1
3956BuEt4-i-Pr2
3957BuEt4-i-Pr3
3958BuEt2-Br, 4-CF31
3959BuEt2-Br, 4-CF32
3960BuEt2-Br, 4-CF33
3961BuEt2-CF3, 4-Br1
3962BuEt2-CF3, 4-Br2
3963BuEt2-CF3, 4-Br3
3964BuEt2-Br, 4-Br1
3965BuEt2-Br, 4-Br2
3966BuEt2-Br, 4-Br3
3967BuEt2-Br, 4-Me1
3968BuEt2-Br, 4-Me2
3969BuEt2-Br, 4-Me3
3970PrPrH1
3971PrPrH2
3972PrPrH3
3973PrPr4-F1
3974PrPr4-F2
3975PrPr4-F3
3976PrPr5-F1
3977PrPr5-F2
3978PrPr5-F3
3979PrPr4-Cl1
3980PrPr4-Cl2
3981PrPr4-Cl3
3982PrPr4-Br1
3983PrPr4-Br2
3984PrPr4-Br3
3985PrPr4-Me1
3986PrPr4-Me2
3987PrPr4-Me3
3988PrPr4-CF31
3989PrPr4-CF32
3990PrPr4-CF33
3991PrPr4-OH1
3992PrPr4-OH2
3993PrPr4-OH3
3994PrPr4-OMe1
3995PrPr4-OMe2
3996PrPr4-OMe3
3997PrPr4-OMeF1
3998PrPr4-OMeF2
3999PrPr4-OMeF3
4000PrPr4-OCF31
4001PrPr4-OCF32
4002PrPr4-OCF33
4003PrPr4-OEtF1
4004PrPr4-OEtF2
4005PrPr4-OEtF3
4006PrPr4-OPrF1
4007PrPr4-OPrF2
4008PrPr4-OPrF3
4009PrPr4-i-Pr1
4010PrPr4-i-Pr2
4011PrPr4-i-Pr3
4012PrPr2-Br, 4-CF31
4013PrPr2-Br, 4-CF32
4014PrPr2-Br, 4-CF33
4015PrPr2-CF3, 4-Br1
4016PrPr2-CF3, 4-Br2
4017PrPr2-CF3, 4-Br3
4018PrPr2-Br, 4-Br1
4019PrPr2-Br, 4-Br2
4020PrPr2-Br, 4-Br3
4021PrPr2-Br, 4-Me1
4022PrPr2-Br, 4-Me2
4023PrPr2-Br, 4-Me3
4024PrPr-FH1
4025PrPr-FH2
4026PrPr-FH3
4027PrPr-F4-F1
4028PrPr-F4-F2
4029PrPr-F4-F3
4030PrPr-F5-F1
4031PrPr-F5-F2
4032PrPr-F5-F3
4033PrPr-F4-Cl1
4034PrPr-F4-Cl2
4035PrPr-F4-Cl3
4036PrPr-F4-Br1
4037PrPr-F4-Br2
4038PrPr-F4-Br3
4039PrPr-F4-Me1
4040PrPr-F4-Me2
4041PrPr-F4-Me3
4042PrPr-F4-CF31
4043PrPr-F4-CF32
4044PrPr-F4-CF33
4045PrPr-F4-OH1
4046PrPr-F4-OH2
4047PrPr-F4-OH3
4048PrPr-F4-OMe1
4049PrPr-F4-OMe2
4050PrPr-F4-OMe3
4051PrPr-F4-OMeF1
4052PrPr-F4-OMeF2
4053PrPr-F4-OMeF3
4054PrPr-F4-OCF31
4055PrPr-F4-OCF32
4056PrPr-F4-OCF33
4057PrPr-F4-OEtF1
4058PrPr-F4-OEtF2
4059PrPr-F4-OEtF3
4060PrPr-F4-OPrF1
4061PrPr-F4-OPrF2
4062PrPr-F4-OPrF3
4063PrPr-F4-i-Pr1
4064PrPr-F4-i-Pr2
4065PrPr-F4-i-Pr3
4066PrPr-F2-Br, 4-CF31
4067PrPr-F2-Br, 4-CF32
4068PrPr-F2-Br, 4-CF33
4069PrPr-F2-CF3, 4-Br1
4070PrPr-F2-CF3, 4-Br2
4071PrPr-F2-CF3, 4-Br3
4072PrPr-F2-Br, 4-Br1
4073PrPr-F2-Br, 4-Br2
4074PrPr-F2-Br, 4-Br3
4075PrPr-F2-Br, 4-Me1
4076PrPr-F2-Br, 4-Me2
4077PrPr-F2-Br, 4-Me3
4078PrEt-FH1
4079PrEt-FH2
4080PrEt-FH3
4081PrEt-F4-F1
4082PrEt-F4-F2
4083PrEt-F4-F3
4084PrEt-F5-F1
4085PrEt-F5-F2
4086PrEt-F5-F3
4087PrEt-F4-Cl1
4088PrEt-F4-Cl2
4089PrEt-F4-Cl3
4090PrEt-F4-Br1
4091PrEt-F4-Br2
4092PrEt-F4-Br3
4093PrEt-F4-Me1
4094PrEt-F4-Me2
4095PrEt-F4-Me3
4096PrEt-F4-CF31
4097PrEt-F4-CF32
4098PrEt-F4-CF33
4099PrEt-F4-OH1
4100PrEt-F4-OH2
4101PrEt-F4-OH3
4102PrEt-F4-OMe1
4103PrEt-F4-OMe2
4104PrEt-F4-OMe3
4105PrEt-F4-OMeF1
4106PrEt-F4-OMeF2
4107PrEt-F4-OMeF3
4108PrEt-F4-OCF31
4109PrEt-F4-OCF32
4110PrEt-F4-OCF33
4111PrEt-F4-OEtF1
4112PrEt-F4-OEtF2
4113PrEt-F4-OEtF3
4114PrEt-F4-OPrF1
4115PrEt-F4-OPrF2
4116PrEt-F4-OPrF3
4117PrEt-F4-i-Pr1
4118PrEt-F4-i-Pr2
4119PrEt-F4-i-Pr3
4120PrEt-F2-Br, 4-CF31
4121PrEt-F2-Br, 4-CF32
4122PrEt-F2-Br, 4-CF33
4123PrEt-F2-CF3, 4-Br1
4124PrEt-F2-CF3, 4-Br2
4125PrEt-F2-CF3, 4-Br3
4126PrEt-F2-Br, 4-Br1
4127PrEt-F2-Br, 4-Br2
4128PrEt-F2-Br, 4-Br3
4129PrEt-F2-Br, 4-Me1
4130PrEt-F2-Br, 4-Me2
4131PrEt-F2-Br, 4-Me3
4132Pr-FEtH1
4133Pr-FEtH2
4134Pr-FEtH3
4135Pr-FEt4-F1
4136Pr-FEt4-F2
4137Pr-FEt4-F3
4138Pr-FEt5-F1
4139Pr-FEt5-F2
4140Pr-FEt5-F3
4141Pr-FEt4-Cl1
4142Pr-FEt4-Cl2
4143Pr-FEt4-Cl3
4144Pr-FEt4-Br1
4145Pr-FEt4-Br2
4146Pr-FEt4-Br3
4147Pr-FEt4-Me1
4148Pr-FEt4-Me2
4149Pr-FEt4-Me3
4150Pr-FEt4-CF31
4151Pr-FEt4-CF32
4152Pr-FEt4-CF33
4153Pr-FEt4-OH1
4154Pr-FEt4-OH2
4155Pr-FEt4-OH3
4156Pr-FEt4-OMe1
4157Pr-FEt4-OMe2
4158Pr-FEt4-OMe3
4159Pr-FEt4-OMeF1
4160Pr-FEt4-OMeF2
4161Pr-FEt4-OMeF3
4162Pr-FEt4-OCF31
4163Pr-FEt4-OCF32
4164Pr-FEt4-OCF33
4165Pr-FEt4-OEtF1
4166Pr-FEt4-OEtF2
4167Pr-FEt4-OEtF3
4168Pr-FEt4-OPrF1
4169Pr-FEt4-OPrF2
4170Pr-FEt4-OPrF3
4171Pr-FEt4-i-Pr1
4172Pr-FEt4-i-Pr2
4173Pr-FEt4-i-Pr3
4174Pr-FEt2-Br, 4-CF31
4175Pr-FEt2-Br, 4-CF32
4176Pr-FEt2-Br, 4-CF33
4177Pr-FEt2-CF3, 4-Br1
4178Pr-FEt2-CF3, 4-Br2
4179Pr-FEt2-CF3, 4-Br3
4180Pr-FEt2-Br, 4-Br1
4181Pr-FEt2-Br, 4-Br2
4182Pr-FEt2-Br, 4-Br3
4183Pr-FEt2-Br, 4-Me1
4184Pr-FEt2-Br, 4-Me2
4185Pr-FEt2-Br, 4-Me3
4186BuEt-FH1
4187BuEt-FH2
4188BuEt-FH3
4189BuEt-F4-F1
4190BuEt-F4-F2
4191BuEt-F4-F3
4192BuEt-F5-F1
4193BuEt-F5-F2
4194BuEt-F5-F3
4195BuEt-F4-Cl1
4196BuEt-F4-Cl2
4197BuEt-F4-Cl3
4198BuEt-F4-Br1
4199BuEt-F4-Br2
4200BuEt-F4-Br3
4201BuEt-F4-Me1
4202BuEt-F4-Me2
4203BuEt-F4-Me3
4204BuEt-F4-CF31
4205BuEt-F4-CF32
4206BuEt-F4-CF33
4207BuEt-F4-OH1
4208BuEt-F4-OH2
4209BuEt-F4-OH3
4210BuEt-F4-OMe1
4211BuEt-F4-OMe2
4212BuEt-F4-OMe3
4213BuEt-F4-OMeF1
4214BuEt-F4-OMeF2
4215BuEt-F4-OMeF3
4216BuEt-F4-OCF31
4217BuEt-F4-OCF32
4218BuEt-F4-OCF33
4219BuEt-F4-OEtF1
4220BuEt-F4-OEtF2
4221BuEt-F4-OEtF3
4222BuEt-F4-OPrF1
4223BuEt-F4-OPrF2
4224BuEt-F4-OPrF3
4225BuEt-F4-i-Pr1
4226BuEt-F4-i-Pr2
4227BuEt-F4-i-Pr3
4228BuEt-F2-Br, 4-CF31
4229BuEt-F2-Br, 4-CF32
4230BuEt-F2-Br, 4-CF33
4231BuEt-F2-CF3, 4-Br1
4232BuEt-F2-CF3, 4-Br2
4233BuEt-F2-CF3, 4-Br3
4234BuEt-F2-Br, 4-Br1
4235BuEt-F2-Br, 4-Br2
4236BuEt-F2-Br, 4-Br3
4237BuEt-F2-Br, 4-Me1
4238BuEt-F2-Br, 4-Me2
4239BuEt-F2-Br, 4-Me3
4240Bu-FEtH1
4241Bu-FEtH2
4242Bu-FEtH3
4243Bu-FEt4-F1
4244Bu-FEt4-F2
4245Bu-FEt4-F3
4246Bu-FEt5-F1
4247Bu-FEt5-F2
4248Bu-FEt5-F3
4249Bu-FEt4-Cl1
4250Bu-FEt4-Cl2
4251Bu-FEt4-Cl3
4252Bu-FEt4-Br1
4253Bu-FEt4-Br2
4254Bu-FEt4-Br3
4255Bu-FEt4-Me1
4256Bu-FEt4-Me2
4257Bu-FEt4-Me3
4258Bu-FEt4-CF31
4259Bu-FEt4-CF32
4260Bu-FEt4-CF33
4261Bu-FEt4-OH1
4262Bu-FEt4-OH2
4263Bu-FEt4-OH3
4264Bu-FEt4-OMe1
4265Bu-FEt4-OMe2
4266Bu-FEt4-OMe3
4267Bu-FEt4-OMeF1
4268Bu-FEt4-OMeF2
4269Bu-FEt4-OMeF3
4270Bu-FEt4-OCF31
4271Bu-FEt4-OCF32
4272Bu-FEt4-OCF33
4273Bu-FEt4-OEtF1
4274Bu-FEt4-OEtF2
4275Bu-FEt4-OEtF3
4276Bu-FEt4-OPrF1
4277Bu-FEt4-OPrF2
4278Bu-FEt4-OPrF3
4279Bu-FEt4-i-Pr1
4280Bu-FEt4-i-Pr2
4281Bu-FEt4-i-Pr3
4282Bu-FEt2-Br, 4-CF31
4283Bu-FEt2-Br, 4-CF32
4284Bu-FEt2-Br, 4-CF33
4285Bu-FEt2-CF3, 4-Br1
4286Bu-FEt2-CF3, 4-Br2
4287Bu-FEt2-CF3, 4-Br3
4288Bu-FEt2-Br, 4-Br1
4289Bu-FEt2-Br, 4-Br2
4290Bu-FEt2-Br, 4-Br3
4291Bu-FEt2-Br, 4-Me1
4292Bu-FEt2-Br, 4-Me2
4293Bu-FEt2-Br, 4-Me3
4294FCH2—CH═CH—CH2MeH1
4295FCH2—CH═CH—CH2MeH2
4296FCH2—CH═CH—CH2MeH3
4297FCH2—CH═CH—CH2Me4-F1
4298FCH2—CH═CH—CH2Me4-F2
4299FCH2—CH═CH—CH2Me4-F3
4300FCH2—CH═CH—CH2Me5-F1
4301FCH2—CH═CH—CH2Me5-F2
4302FCH2—CH═CH—CH2Me5-F3
4303FCH2—CH═CH—CH2Me4-Cl1
4304FCH2—CH═CH—CH2Me4-Cl2
4305FCH2—CH═CH—CH2Me4-Cl3
4306FCH2—CH═CH—CH2Me4-Br1
4307FCH2—CH═CH—CH2Me4-Br2
4308FCH2—CH═CH—CH2Me4-Br3
4309FCH2—CH═CH—CH2Me4-Me1
4310FCH2—CH═CH—CH2Me4-Me2
4311FCH2—CH═CH—CH2Me4-Me3
4312FCH2—CH═CH—CH2Me4-CF31
4313FCH2—CH═CH—CH2Me4-CF32
4314FCH2—CH═CH—CH2Me4-CF33
4315FCH2—CH═CH—CH2Me4-OH1
4316FCH2—CH═CH—CH2Me4-OH2
4317FCH2—CH═CH—CH2Me4-OH3
4318FCH2—CH═CH—CH2Me4-OMe1
4319FCH2—CH═CH—CH2Me4-OMe2
4320FCH2—CH═CH—CH2Me4-OMe3
4321FCH2—CH═CH—CH2Me4-OMeF1
4322FCH2—CH═CH—CH2Me4-OMeF2
4323FCH2—CH═CH—CH2Me4-OMeF3
4324FCH2—CH═CH—CH2Me4-OCF31
4325FCH2—CH═CH—CH2Me4-OCF32
4326FCH2—CH═CH—CH2Me4-OCF33
4327FCH2—CH═CH—CH2Me4-OEtF1
4328FCH2—CH═CH—CH2Me4-OEtF2
4329FCH2—CH═CH—CH2Me4-OEtF3
4330FCH2—CH═CH—CH2Me4-OPrF1
4331FCH2—CH═CH—CH2Me4-OPrF2
4332FCH2—CH═CH—CH2Me4-OPrF3
4333FCH2—CH═CH—CH2Me4-i-Pr1
4334FCH2—CH═CH—CH2Me4-i-Pr2
4335FCH2—CH═CH—CH2Me4-i-Pr3
4336FCH2—CH═CH—CH2Me2-Br, 4-CF31
4337FCH2—CH═CH—CH2Me2-Br, 4-CF32
4338FCH2—CH═CH—CH2Me2-Br, 4-CF33
4339FCH2—CH═CH—CH2Me2-CF3, 4-Br1
4340FCH2—CH═CH—CH2Me2-CF3, 4-Br2
4341FCH2—CH═CH—CH2Me2-CF3, 4-Br3
4342FCH2—CH═CH—CH2Me2-Br, 4-Br1
4343FCH2—CH═CH—CH2Me2-Br, 4-Br2
4344FCH2—CH═CH—CH2Me2-Br, 4-Br3
4345FCH2—CH═CH—CH2Me2-Br, 4-Me1
4346FCH2—CH═CH—CH2Me2-Br, 4-Me2
4347FCH2—CH═CH—CH2Me2-Br, 4-Me3
4348FCH2—CH═CH—CH2EtH1
4349FCH2—CH═CH—CH2EtH2
4350FCH2—CH═CH—CH2EtH3
4351FCH2—CH═CH—CH2Et4-F1
4352FCH2—CH═CH—CH2Et4-F2
4353FCH2—CH═CH—CH2Et4-F3
4354FCH2—CH═CH—CH2Et5-F1
4355FCH2—CH═CH—CH2Et5-F2
4356FCH2—CH═CH—CH2Et5-F3
4357FCH2—CH═CH—CH2Et4-Cl1
4358FCH2—CH═CH—CH2Et4-Cl2
4359FCH2—CH═CH—CH2Et4-Cl3
4360FCH2—CH═CH—CH2Et4-Br1
4361FCH2—CH═CH—CH2Et4-Br2
4362FCH2—CH═CH—CH2Et4-Br3
4363FCH2—CH═CH—CH2Et4-Me1
4364FCH2—CH═CH—CH2Et4-Me2
4365FCH2—CH═CH—CH2Et4-Me3
4366FCH2—CH═CH—CH2Et4-CF31
4367FCH2—CH═CH—CH2Et4-CF32
4368FCH2—CH═CH—CH2Et4-CF33
4369FCH2—CH═CH—CH2Et4-OH1
4370FCH2—CH═CH—CH2Et4-OH2
4371FCH2—CH═CH—CH2Et4-OH3
4372FCH2—CH═CH—CH2Et4-OMe1
4373FCH2—CH═CH—CH2Et4-OMe2
4374FCH2—CH═CH—CH2Et4-OMe3
4375FCH2—CH═CH—CH2Et4-OMeF1
4376FCH2—CH═CH—CH2Et4-OMeF2
4377FCH2—CH═CH—CH2Et4-OMeF3
4378FCH2—CH═CH—CH2Et4-OCF31
4379FCH2—CH═CH—CH2Et4-OCF32
4380FCH2—CH═CH—CH2Et4-OCF33
4381FCH2—CH═CH—CH2Et4-OEtF1
4382FCH2—CH═CH—CH2Et4-OEtF2
4383FCH2—CH═CH—CH2Et4-OEtF3
4384FCH2—CH═CH—CH2Et4-OPrF1
4385FCH2—CH═CH—CH2Et4-OPrF2
4386FCH2—CH═CH—CH2Et4-OPrF3
4387FCH2—CH═CH—CH2Et4-i-Pr1
4388FCH2—CH═CH—CH2Et4-i-Pr2
4389FCH2—CH═CH—CH2Et4-i-Pr3
4390FCH2—CH═CH—CH2Et2-Br, 4-CF31
4391FCH2—CH═CH—CH2Et2-Br, 4-CF32
4392FCH2—CH═CH—CH2Et2-Br, 4-CF33
4393FCH2—CH═CH—CH2Et2-CF3, 4-Br1
4394FCH2—CH═CH—CH2Et2-CF3, 4-Br2
4395FCH2—CH═CH—CH2Et2-CF3, 4-Br3
4396FCH2—CH═CH—CH2Et2-Br, 4-Br1
4397FCH2—CH═CH—CH2Et2-Br, 4-Br2
4398FCH2—CH═CH—CH2Et2-Br, 4-Br3
4399FCH2—CH═CH—CH2Et2-Br, 4-Me1
4400FCH2—CH═CH—CH2Et2-Br, 4-Me2
4401FCH2—CH═CH—CH2Et2-Br, 4-Me3
4402FCH2—CH═CH—CH2Et-FH1
4403FCH2—CH═CH—CH2Et-FH2
4404FCH2—CH═CH—CH2Et-FH3
4405FCH2—CH═CH—CH2Et-F4-F1
4406FCH2—CH═CH—CH2Et-F4-F2
4407FCH2—CH═CH—CH2Et-F4-F3
4408FCH2—CH═CH—CH2Et-F5-F1
4409FCH2—CH═CH—CH2Et-F5-F2
4410FCH2—CH═CH—CH2Et-F5-F3
4411FCH2—CH═CH—CH2Et-F4-Cl1
4412FCH2—CH═CH—CH2Et-F4-Cl2
4413FCH2—CH═CH—CH2Et-F4-Cl3
4414FCH2—CH═CH—CH2Et-F4-Br1
4415FCH2—CH═CH—CH2Et-F4-Br2
4416FCH2—CH═CH—CH2Et-F4-Br3
4417FCH2—CH═CH—CH2Et-F4-Me1
4418FCH2—CH═CH—CH2Et-F4-Me2
4419FCH2—CH═CH—CH2Et-F4-Me3
4420FCH2—CH═CH—CH2Et-F4-CF31
4421FCH2—CH═CH—CH2Et-F4-CF32
4422FCH2—CH═CH—CH2Et-F4-CF33
4423FCH2—CH═CH—CH2Et-F4-OH1
4424FCH2—CH═CH—CH2Et-F4-OH2
4425FCH2—CH═CH—CH2Et-F4-OH3
4426FCH2—CH═CH—CH2Et-F4-OMe1
4427FCH2—CH═CH—CH2Et-F4-OMe2
4428FCH2—CH═CH—CH2Et-F4-OMe3
4429FCH2—CH═CH—CH2Et-F4-OMeF1
4430FCH2—CH═CH—CH2Et-F4-OMeF2
4431FCH2—CH═CH—CH2Et-F4-OMeF3
4432FCH2—CH═CH—CH2Et-F4-OCF31
4433FCH2—CH═CH—CH2Et-F4-OCF32
4434FCH2—CH═CH—CH2Et-F4-OCF33
4435FCH2—CH═CH—CH2Et-F4-OEtF1
4436FCH2—CH═CH—CH2Et-F4-OEtF2
4437FCH2—CH═CH—CH2Et-F4-OEtF3
4438FCH2—CH═CH—CH2Et-F4-OPrF1
4439FCH2—CH═CH—CH2Et-F4-OPrF2
4440FCH2—CH═CH—CH2Et-F4-OPrF3
4441FCH2—CH═CH—CH2Et-F4-i-Pr1
4442FCH2—CH═CH—CH2Et-F4-i-Pr2
4443FCH2—CH═CH—CH2Et-F4-i-Pr3
4444FCH2—CH═CH—CH2Et-F2-Br, 4-CF31
4445FCH2—CH═CH—CH2Et-F2-Br, 4-CF32
4446FCH2—CH═CH—CH2Et-F2-Br, 4-CF33
4447FCH2—CH═CH—CH2Et-F2-CF3, 4-Br1
4448FCH2—CH═CH—CH2Et-F2-CF3, 4-Br2
4449FCH2—CH═CH—CH2Et-F2-CF3, 4-Br3
4450FCH2—CH═CH—CH2Et-F2-Br, 4-Br1
4451FCH2—CH═CH—CH2Et-F2-Br, 4-Br2
4452FCH2—CH═CH—CH2Et-F2-Br, 4-Br3
4453FCH2—CH═CH—CH2Et-F2-Br, 4-Me1
4454FCH2—CH═CH—CH2Et-F2-Br, 4-Me2
4455FCH2—CH═CH—CH2Et-F2-Br, 4-Me3

TABLE 5
Substituent list for compounds of general structure X.
X
embedded image
Compound #R1 =R2 =R3 =
4456BuEtH
4457BuEt2-t-Bu
4458BuEt2-Br
4459BuEt3-Br
4460BuEt4-Br
4461BuEt2-I
4462BuEt3-I
4463BuEt4-I
4464BuEt2-SnMe3
4465BuEt3-SnMe3
4466BuEt4-SnMe3
4467BuEt2-Me
4468BuEt3-Me
4469BuEt4-Me
4470BuEt2-OH
4471BuEt3-OH
4472BuEt4-OH
4473BuEt2-OMe
4474BuEt3-OMe
4475BuEt4-OMe
4476BuEt2-OMeF
4477BuEt3-OMeF
4478BuEt4-OMeF
4479BuEt2-OCF3
4480BuEt3-OCF3
4481BuEt4-OCF3
4482BuEt2-OEtF
4483BuEt3-OEtF
4484BuEt4-OEtF
4485BuEt2-OPrF
4486BuEt3-OPrF
4487BuEt4-OPrF
4488BuEt2-SH
4489BuEt3-SH
4490BuEt4-SH
4491BuEt2-SMe
4492BuEt3-SMe
4493BuEt4-SMe
4494BuEt2-SMeF
4495BuEt3-SMeF
4496BuEt4-SMeF
4497BuEt2-SCF3
4498BuEt3-SCF3
4499BuEt4-SCF3
4500BuEt2-SEtF
4501BuEt3-SEtF
4502BuEt4-SEtF
4503BuEt2-SPrF
4504BuEt3-SPrF
4505BuEt4-SPrF
4506BuEt2-OMe, 4-OMe
4507BuEt2-Me, 5-OH
4508BuEt2-Me, 5-OMe
4509BuEt2-Me, 5-OMeF
4510BuEt2-Me, 5-OEtF
4511BuEt2-Me, 5-OPrF
4512BuEt2-Me, 4-OH
4513BuEt2-Me, 4-OMe
4514BuEt2-Me, 4-OMeF
4515BuEt2-Me, 4-OCF3
4516BuEt2-Me, 4-OEtF
4517BuEt2-Me, 4-OPrF
4518BuEt2-OH, 4-Me
4519BuEt2-OMe, 4-Me
4520BuEt2-OMeF, 4-Me
4521BuEt2-OCF3, 4-Me
4522BuEt2-OEtF, 4-Me
4523BuEt2-OPrF, 4-Me
4524BuEt2-Cl, 4-OH
4525BuEt2-Cl, 4-OMe
4526BuEt2-Cl, 4-OMeF
4527BuEt2-Cl, 4-OCF3
4528BuEt2-Cl, 4-OEtF
4529BuEt2-Cl, 4-OPrF
4530BuEt2-F, 4-F
4531BuEt2-Cl, 4-Cl
4532BuEt2-Cl, 4-F
4533BuEt2-Cl, 4-NO2
4534BuEt2-Cl, 4-NH2
4535BuEt2-Cl, 4-NHMe
4536BuEt2-Cl, 4-NMe2
4537BuEt2-Cl, 4-NMe3OTf
4538BuEt2-Cl, 4-NMe3I
4539BuEt2-Cl, 5-F
4540BuEt2-Cl, 5-NO2
4541BuEt2-Cl, 5-NH2
4542BuEt2-Cl, 5-NHMe
4543BuEt2-Cl, 5-NMe2
4544BuEt2-Cl, 5-NMe3OTf
4545BuEt2-Cl, 5-NMe3I
4546BuEt2-F, 4-Cl
4547BuEt2-NO2, 4-Cl
4548BuEt2-NH2, 4-Cl
4549BuEt2-NHMe, 4-Cl
4550BuEt2-NMe2, 4-Cl
4551BuEt2-NMe3OTf, 4-Cl
4552BuEt2-NMe3I, 4-Cl
4553BuEt2-F, 5-Cl
4554BuEt2-NO2, 5-Cl
4555BuEt2-NH2, 5-Cl
4556BuEt2-NHMe, 5-Cl
4557BuEt2-NMe2, 5-Cl
4558BuEt2-NMe3OTF, 5-Cl
4559BuEt2-NMe3I, 5-Cl
4560BuEt2-Br, 4-F
4561BuEt2-Br, 4-NO2
4562BuEt2-Br, 4-NH2
4563BuEt2-Br, 4-NHMe
4564BuEt2-Br, 4-NMe2
4565BuEt2-Br, 4-NMe3OTf
4566BuEt2-Br, 4-NMe3I
4567BuEt2-Br, 5-F
4568BuEt2-Br, 5-NO2
4569BuEt2-Br, 5-NH2
4570BuEt2-Br, 5-NHMe
4571BuEt2-Br, 5-NMe3
4572BuEt2-Br, 5-NMe3OTf
4573BuEt2-Br, 5-NMe3I
4574BuEt2-F, 4-Br
4575BuEt2-NO2, 4-Br
4576BuEt2-NH2, 4-Br
4577BuEt2-NHMe, 4-Br
4578BuEt2-NMe3, 4-Br
4579BuEt2-NMe3OTf, 4-Br
4580BuEt2-NMe3I, 4-Br
4581BuEt2-I, 4-F
4582BuEt2-I, 4-NO2
4583BuEt2-I, 4-NH2
4584BuEt2-I, 4-NHMe
4585BuEt2-I, 4-NMe2
4586BuEt2-I, 4-NMe3OTf
4587BuEt2-I, 4-NMe3I
4588BuEt2-F, 4-I
4589BuEt2-NO2, 4-I
4590BuEt2-NH2, 4-I
4591BuEt2-NHMe, 4-I
4592BuEt2-NMe2, 4-I
4593BuEt2-NMe3OTf, 4-I
4594BuEt2-NMe3I, 4-I
4595BuEt2-Me, 3-F
4596BuEt2-Me, 3-NO2
4597BuEt2-Me, 3-NH2
4598BuEt2-Me, 3-NHMe
4599BuEt2-Me, 3-NMe2
4600BuEt2-Me, 3-NMe3OTf
4601BuEt2-Me, 3-NMe3I
4602BuEt2-Me, 4-F
4603BuEt2-Me, 4-NO2
4604BuEt2-Me, 4-NH2
4605BuEt2-Me, 4-NHMe
4606BuEt2-Me, 4-NMe2
4607BuEt2-Me, 4-NMe3OTf
4608BuEt2-Me, 4-NMe3I
4609BuEt2-Me, 5-F
4610BuEt2-Me, 5-NO2
4611BuEt2-Me, 5-NH2
4612BuEt2-Me, 5-NHMe
4613BuEt2-Me, 5-NMe2
4614BuEt2-Me, 5-NMe3OTf
4615BuEt2-Me, 5-NMe3I
4616BuEt2-F, 4-Me
4617BuEt2-NO2, 4-Me
4618BuEt2-NH2, 4-Me
4619BuEt2-NHMe, 4-Me
4620BuEt2-NMe2, 4-Me
4621BuEt2-NMe3, 4-Me
4622BuEt2-NMe3OTf, 4-Me
4623BuEt2-NMe3I, 4-Me
4624BuEt2-SnMe3, 4-F
4625BuEt2-SnMe3, 5-F
4626BuEt2-F, 4-SnMe3
4627BuEt2-Br, 6-Cl, 4-F
4628BuEt2-Br, 6-Cl, 4-NO2
4629BuEt2-Br, 6-Cl, 4-NH2
4630BuEt2-Br, 6-Cl, 4-NHMe
4631BuEt2-Br, 6-Cl, 4-NMe2
4632BuEt2-Br, 6-Cl, 4-NMe3OTf
4633BuEt2-Br, 6-Cl, 4-NMe3I
4634BuEt2-Me, 6-Cl, 4-F
4635BuEt2-SnMe3, 6-Cl, 4-F
4636BuEt2-Cl, 4-Me
4637BuEt2-Cl, 4-Br
4638BuEt2-Cl, 4-SnMe3
4639BuEt2-Br, 4-Cl
4640BuEt2-SnMe3, 4-Cl
4641BuEt2-Me, 4-Cl
4642BuEt2-Br, 4-Br
4643BuEt2-Br, 4-Me
4644BuEt2-Br, 4-SnMe3
4645BuEt2-SnMe3, 4-Br
4646BuEt2-Me, 4-Br
4647BuEt2-Me, 4-SnMe3
4648BuEt2-SnMe3, 4-Me
4649BuEt2-Me, 4-Me
4650BuEt2-Et, 4-Br
4651BuEt2-Et, 4-SnMe3
4652BuEt2-Et, 4-Me
4653BuEt2-Me, 4-Me, 6-Me
4654BuEt2-Me, 4-Br, 6-Me
4655BuEt2-Me, 4-SnMe3, 6-Me
4656BuEt2-Et, 6-Me
4657BuEt2-Br, 4-i-Pr
4658BuEt2-SnMe3, 4-i-Pr
4659BuEt2-Me, 4-i-Pr
4660BuEt2-Br, 4-Br, 6-Br
4661BuEt2-Br, 4-Me, 6-Br
4662BuEt2-Br, 4-SnMe3, 6-Br
4663BuEt2-SnMe3, 4-Br, 6-Br
4664BuEt2-Br, 4-Br, 6-Me
4665BuEt2-Br, 4-CF3, 6-Br
4666BuEt2-Br, 4-Br, 6-CF3
4667BuEt2-CF3, 4-CF3
4668BuEt2-Cl, 4-CF3
4669BuEt2-CF3, 4-Cl
4670BuEt2-Br, 4-CF3
4671BuEt2-SnMe3, 4-CF3
4672BuEt2-Me, 4-CF3
4673BuEt2-CF3, 4-Br
4674BuEt2-CF3, 4-SnMe3
4675BuEt2-CF3, 4-Me
4676BuEt2-Br, 4-OH
4677BuEt2-Br, 4-OMe
4678BuEt2-Br, 4-OMeF
4679BuEt2-Br, 4-OCF3
4680BuEt2-Br, 4-OEtF
4681BuEt2-Br, 4-OPrF
4682BuEt2-OH, 4-Br
4683BuEt2-OMe, 4-Br
4684BuEt2-OMeF, 4-Br
4685BuEt2-OCF3, 4-Br
4686BuEt2-OEtF, 4-Br
4687BuEt2-OPrF, 4-Br
4688BuEt2-I, 4-OH
4689BuEt2-I, 4-OMe
4690BuEt2-I, 4-OMeF
4691BuEt2-I, 4-OCF3
4692BuEt2-I, 4-OEtF
4693BuEt2-I, 4-OPrF
4694BuEt2-OH, 4-I
4695BuEt2-OMe, 4-I
4696BuEt2-OMeF, 4-I
4697BuEt2-OCF3, 4-I
4698BuEt2-OEtF, 4-I
4699BuEt2-OPrF, 4-I
4700BuEt2-SnMe3, 4-OH
4701BuEt2-SnMe3, 4-OMe
4702BuEt2-SnMe3, 4-OMeF
4703BuEt2-SnMe3, 4-OCF3
4704BuEt2-SnMe3, 4-OEtF
4705BuEt2-SnMe3, 4-OPrF
4706BuEt2-OH, 2-SnMe3
4707BuEt2-OMe, 4-SnMe3
4708BuEt2-OMeF, 4-SnMe3
4709BuEt4-OCF3, 4-SnMe3
4710PrPrH
4711PrPr2-t-Bu
4712PrPr2-Br
4713PrPr3-Br
4714PrPr4-Br
4715PrPr2-I
4716PrPr3-I
4717PrPr4-I
4718PrPr2-SnMe3
4719PrPr3-SnMe3
4720PrPr4-SnMe3
4721PrPr2-Me
4722PrPr3-Me
4723PrPr4-Me
4724PrPr2-OH
4725PrPr3-OH
4726PrPr4-OH
4727PrPr2-OMe
4728PrPr3-OMe
4729PrPr4-OMe
4730PrPr2-OMeF
4731PrPr3-OMeF
4732PrPr4-OMeF
4733PrPr2-OCF3
4734PrPr3-OCF3
4735PrPr4-OCF3
4736PrPr2-OEtF
4737PrPr3-OEtF
4738PrPr4-OEtF
4739PrPr2-OPrF
4740PrPr3-OPrF
4741PrPr4-OPrF
4742PrPr2-SH
4743PrPr3-SH
4744PrPr4-SH
4745PrPr2-SMe
4746PrPr3-SMe
4747PrPr4-SMe
4748PrPr2-SMeF
4749PrPr3-SMeF
4750PrPr4-SMeF
4751PrPr2-SCF3
4752PrPr3-SCF3
4753PrPr4-SCF3
4754PrPr2-SEtF
4755PrPr3-SEtF
4756PrPr4-SEtF
4757PrPr2-SPrF
4758PrPr3-SPrF
4759PrPr4-SPrF
4760PrPr2-OMe, 4-OMe
4761PrPr2-Me, 5-OH
4762PrPr2-Me, 5-OMe
4763PrPr2-Me, 5-OMeF
4764PrPr2-Me, 5-OEtF
4765PrPr2-Me, 5-OPrF
4766PrPr2-Me, 4-OH
4767PrPr2-Me, 4-OMe
4768PrPr2-Me, 4-OMeF
4769PrPr2-Me, 4-OCF3
4770PrPr2-Me, 4-OEtF
4771PrPr2-Me, 4-OPrF
4772PrPr2-OH, 4-Me
4773PrPr2-OMe, 4-Me
4774PrPr2-OMeF, 4-Me
4775PrPr2-OCF3, 4-Me
4776PrPr2-OEtF, 4-Me
4777PrPr2-OPrF, 4-Me
4778PrPr2-Cl, 4-OH
4779PrPr2-Cl, 4-OMe
4780PrPr2-Cl, 4-OMeF
4781PrPr2-Cl, 4-OCF3
4782PrPr2-Cl, 4-OEtF
4783PrPr2-Cl, 4-OPrF
4784PrPr2-F, 4-F
4785PrPr2-Cl, 4-Cl
4786PrPr2-Cl, 4-F
4787PrPr2-Cl, 4-NO2
4788PrPr2-Cl, 4-NH2
4789PrPr2-Cl, 4-NHMe
4790PrPr2-Cl, 4-NMe2
4791PrPr2-Cl, 4-NMe3OTf
4792PrPr2-Cl, 4-NMe3I
4793PrPr2-Cl, 5-F
4794PrPr2-Cl, 5-NO2
4795PrPr2-Cl, 5-NH2
4796PrPr2-Cl, 5-NHMe
4797PrPr2-Cl, 5-NMe2
4798PrPr2-Cl, 5-NMe3OTf
4799PrPr2-Cl, 5-NMe3I
4800PrPr2-F, 4-Cl
4801PrPr2-NO2, 4-Cl
4802PrPr2-NH2, 4-Cl
4803PrPr2-NHMe, 4-Cl
4804PrPr2-NMe2, 4-Cl
4805PrPr2-NMe3OTf, 4-Cl
4806PrPr2-NMe3I, 4-Cl
4807PrPr2-F, 5-Cl
4808PrPr2-NO2, 5-Cl
4809PrPr2-NH2, 5-Cl
4810PrPr2-NHMe, 5-Cl
4811PrPr2-NMe2, 5-Cl
4812PrPr2-NMe3OTF, 5-Cl
4813PrPr2-NMe3I, 5-Cl
4814PrPr2-Br, 4-F
4815PrPr2-Br, 4-NO2
4816PrPr2-Br, 4-NH2
4817PrPr2-Br, 4-NHMe
4818PrPr2-Br, 4-NMe2
4819PrPr2-Br, 4-NMe3OTf
4820PrPr2-Br, 4-NMe3I
4821PrPr2-Br, 5-F
4822PrPr2-Br, 5-NO2
4823PrPr2-Br, 5-NH2
4824PrPr2-Br, 5-NHMe
4825PrPr2-Br, 5-NMe3
4826PrPr2-Br, 5-NMe3OTf
4827PrPr2-Br, 5-NMe3I
4828PrPr2-F, 4-Br
4829PrPr2-NO2, 4-Br
4830PrPr2-NH2, 4-Br
4831PrPr2-NHMe, 4-Br
4832PrPr2-NMe3, 4-Br
4833PrPr2-NMe3OTf, 4-Br
4834PrPr2-NMe3I, 4-Br
4835PrPr2-I, 4-F
4836PrPr2-I, 4-NO2
4837PrPr2-I, 4-NH2
4838PrPr2-I, 4-NHMe
4839PrPr2-I, 4-NMe2
4840PrPr2-I, 4-NMe3OTf
4841PrPr2-I, 4-NMe3I
4842PrPr2-F, 4-I
4843PrPr2-NO2, 4-I
4844PrPr2-NH2, 4-I
4845PrPr2-NHMe, 4-I
4846PrPr2-NMe2, 4-I
4847PrPr2-NMe3OTf, 4-I
4848PrPr2-NMe3I, 4-I
4849PrPr2-Me, 3-F
4850PrPr2-Me, 3-NO2
4851PrPr2-Me, 3-NH2
4852PrPr2-Me, 3-NHMe
4853PrPr2-Me, 3-NMe2
4854PrPr2-Me, 3-NMe3OTf
4855PrPr2-Me, 3-NMe3I
4856PrPr2-Me, 4-F
4857PrPr2-Me, 4-NO2
4858PrPr2-Me, 4-NH2
4859PrPr2-Me, 4-NHMe
4860PrPr2-Me, 4-NMe2
4861PrPr2-Me, 4-NMe3OTf
4862PrPr2-Me, 4-NMe3I
4863PrPr2-Me, 5-F
4864PrPr2-Me, 5-NO2
4865PrPr2-Me, 5-NH2
4866PrPr2-Me, 5-NHMe
4867PrPr2-Me, 5-NMe2
4868PrPr2-Me, 5-NMe3OTf
4869PrPr2-Me, 5-NMe3I
4870PrPr2-F, 4-Me
4871PrPr2-NO2, 4-Me
4872PrPr2-NH2, 4-Me
4873PrPr2-NHMe, 4-Me
4874PrPr2-NMe2, 4-Me
4875PrPr2-NMe3, 4-Me
4876PrPr2-NMe3OTf, 4-Me
4877PrPr2-NMe3I, 4-Me
4878PrPr2-SnMe3, 4-F
4879PrPr2-SnMe3, 5-F
4880PrPr2-F, 4-SnMe3
4881PrPr2-Br, 6-Cl, 4-F
4882PrPr2-Br, 6-Cl, 4-NO2
4883PrPr2-Br, 6-Cl, 4-NH2
4884PrPr2-Br, 6-Cl, 4-NHMe
4885PrPr2-Br, 6-Cl, 4-NMe2
4886PrPr2-Br, 6-Cl, 4-NMe3OTf
4887PrPr2-Br, 6-Cl, 4-NMe3I
4888PrPr2-Me, 6-Cl, 4-F
4889PrPr2-SnMe3, 6-Cl, 4-F
4890PrPr2-Cl, 4-Me
4891PrPr2-Cl, 4-Br
4892PrPr2-Cl, 4-SnMe3
4893PrPr2-Br, 4-Cl
4894PrPr2-SnMe3, 4-Cl
4895PrPr2-Me, 4-Cl
4896PrPr2-Br, 4-Br
4897PrPr2-Br, 4-Me
4898PrPr2-Br, 4-SnMe3
4899PrPr2-SnMe3, 4-Br
4900PrPr2-Me, 4-Br
4901PrPr2-Me, 4-SnMe3
4902PrPr2-SnMe3, 4-Me
4903PrPr2-Me, 4-Me
4904PrPr2-Et, 4-Br
4905PrPr2-Et, 4-SnMe3
4906PrPr2-Et, 4-Me
4907PrPr2-Me, 4-Me, 6-Me
4908PrPr2-Me, 4-Br, 6-Me
4909PrPr2-Me, 4-SnMe3, 6-Me
4910PrPr2-Et, 6-Me
4911PrPr2-Br, 4-i-Pr
4912PrPr2-SnMe3, 4-i-Pr
4913PrPr2-Me, 4-i-Pr
4914PrPr2-Br, 4-Br, 6-Br
4915PrPr2-Br, 4-Me, 6-Br
4916PrPr2-Br, 4-SnMe3, 6-Br
4917PrPr2-SnMe3, 4,6-Br
4918PrPr2-Br, 4-Br, 6-Me
4919PrPr2-Br, 4-CF3, 6-Br
4920PrPr2-Br, 4-Br, 6-CF3
4921PrPr2-CF3, 4-CF3
4922PrPr2-Cl, 4-CF3
4923PrPr2-CF3, 4-Cl
4924PrPr2-Br, 4-CF3
4925PrPr2-SnMe3, 4-CF3
4926PrPr2-Me, 4-CF3
4927PrPr2-CF3, 4-Br
4928PrPr2-CF3, 4-SnMe3
4929PrPr2-CF3, 4-Me
4930PrPr2-Br, 4-OH
4931PrPr2-Br, 4-OMe
4932PrPr2-Br, 4-OMeF
4933PrPr2-Br, 4-OCF3
4934PrPr2-Br, 4-OEtF
4935PrPr2-Br, 4-OPrF
4936PrPr2-OH, 4-Br
4937PrPr2-OMe, 4-Br
4938PrPr2-OMeF, 4-Br
4939PrPr2-OCF3, 4-Br
4940PrPr2-OEtF, 4-Br
4941PrPr2-OPrF, 4-Br
4942PrPr2-I, 4-OH
4943PrPr2-I, 4-OMe
4944PrPr2-I, 4-OMeF
4945PrPr2-I, 4-OCF3
4946PrPr2-I, 4-OEtF
4947PrPr2-I, 4-OPrF
4948PrPr2-OH, 4-I
4949PrPr2-OMe, 4-I
4950PrPr2-OMeF, 4-I
4951PrPr2-OCF3, 4-I
4952PrPr2-OEtF, 4-I
4953PrPr2-OPrF, 4-I
4954PrPr2-SnMe3, 4-OH
4955PrPr2-SnMe3, 4-OMe
4956PrPr2-SnMe3, 4-OMeF
4957PrPr2-SnMe3, 4-OCF3
4958PrPr2-SnMe3, 4-OEtF
4959PrPr2-SnMe3, 4-OPrF
4960PrPr2-OH, 2-SnMe3
4961PrPr2-OMe, 4-SnMe3
4962PrPr2-OMeF, 4-SnMe3
4963PrPr4-OCF3, 4-SnMe3
4964PrPr2-OEtF, 4-SnMe3
4965PrPr2-OPrF, 4-SnMe3
4966PrPr-FH
4967PrPr-F2-t-Bu
4968PrPr-F2-Br
4969PrPr-F3-Br
4970PrPr-F4-Br
4971PrPr-F2-I
4972PrPr-F3-I
4973PrPr-F4-I
4974PrPr-F2-SnMe3
4975PrPr-F3-SnMe3
4976PrPr-F4-SnMe3
4977PrPr-F2-Me
4978PrPr-F3-Me
4979PrPr-F4-Me
4980PrPr-F2-OH
4981PrPr-F3-OH
4982PrPr-F4-OH
4983PrPr-F2-OMe
4984PrPr-F3-OMe
4985PrPr-F4-OMe
4986PrPr-F2-OMeF
4987PrPr-F3-OMeF
4988PrPr-F4-OMeF
4989PrPr-F2-OCF3
4990PrPr-F3-OCF3
4991PrPr-F4-OCF3
4992PrPr-F2-OEtF
4993PrPr-F3-OEtF
4994PrPr-F4-OEtF
4995PrPr-F2-OPrF
4996PrPr-F3-OPrF
4997PrPr-F4-OPrF
4998PrPr-F2-SH
4999PrPr-F3-SH
5000PrPr-F4-SH
5001PrPr-F2-SMe
5002PrPr-F3-SMe
5003PrPr-F4-SMe
5004PrPr-F2-SMeF
5005PrPr-F3-SMeF
5006PrPr-F4-SMeF
5007PrPr-F2-SCF3
5008PrPr-F3-SCF3
5009PrPr-F4-SCF3
5010PrPr-F2-SEtF
5011PrPr-F3-SEtF
5012PrPr-F4-SEtF
5013PrPr-F2-SPrF
5014PrPr-F3-SPrF
5015PrPr-F4-SPrF
5016PrPr-F2-OMe, 4-OMe
5017PrPr-F2-Me, 5-OH
5018PrPr-F2-Me, 5-OMe
5019PrPr-F2-Me, 5-OMeF
5020PrPr-F2-Me, 5-OEtF
5021PrPr-F2-Me, 5-OPrF
5022PrPr-F2-Me, 4-OH
5023PrPr-F2-Me, 4-OMe
5024PrPr-F2-Me, 4-OMeF
5025PrPr-F2-Me, 4-OCF3
5026PrPr-F2-Me, 4-OEtF
5027PrPr-F2-Me, 4-OPrF
5028PrPr-F2-OH, 4-Me
5029PrPr-F2-OMe, 4-Me
5030PrPr-F2-OMeF, 4-Me
5031PrPr-F2-OCF3, 4-Me
5032PrPr-F2-OEtF, 4-Me
5033PrPr-F2-OPrF, 4-Me
5034PrPr-F2-Cl, 4-OH
5035PrPr-F2-Cl, 4-OMe
5036PrPr-F2-Cl, 4-OMeF
5037PrPr-F2-Cl, 4-OCF3
5038PrPr-F2-Cl, 4-OEtF
5039PrPr-F2-Cl, 4-OPrF
5040PrPr-F2-F, 4-F
5041PrPr-F2-Cl, 4-Cl
5042PrPr-F2-Cl, 4-F
5043PrPr-F2-Cl, 4-NO2
5044PrPr-F2-Cl, 4-NH2
5045PrPr-F2-Cl, 4-NHMe
5046PrPr-F2-Cl, 4-NMe2
5047PrPr-F2-Cl, 4-NMe3OTf
5048PrPr-F2-Cl, 4-NMe3I
5049PrPr-F2-Cl, 5-F
5050PrPr-F2-Cl, 5-NO2
5051PrPr-F2-Cl, 5-NH2
5052PrPr-F2-Cl, 5-NHMe
5053PrPr-F2-Cl, 5-NMe2
5054PrPr-F2-Cl, 5-NMe3OTf
5055PrPr-F2-Cl, 5-NMe3I
5056PrPr-F2-F, 4-Cl
5057PrPr-F2-NO2, 4-Cl
5058PrPr-F2-NH2, 4-Cl
5059PrPr-F2-NHMe, 4-Cl
5060PrPr-F2-NMe2, 4-Cl
5061PrPr-F2-NMe3OTf, 4-Cl
5062PrPr-F2-NMe3I, 4-Cl
5063PrPr-F2-F, 5-Cl
5064PrPr-F2-NO2, 5-Cl
5065PrPr-F2-NH2, 5-Cl
5066PrPr-F2-NHMe, 5-Cl
5067PrPr-F2-NMe2, 5-Cl
5068PrPr-F2-NMe3OTF, 5-Cl
5069PrPr-F2-NMe3I, 5-Cl
5070PrPr-F2-Br, 4-F
5071PrPr-F2-Br, 4-NO2
5072PrPr-F2-Br, 4-NH2
5073PrPr-F2-Br, 4-NHMe
5074PrPr-F2-Br, 4-NMe2
5075PrPr-F2-Br, 4-NMe3OTf
5076PrPr-F2-Br, 4-NMe3I
5077PrPr-F2-Br, 5-F
5078PrPr-F2-Br, 5-NO2
5079PrPr-F2-Br, 5-NH2
5080PrPr-F2-Br, 5-NHMe
5081PrPr-F2-Br, 5-NMe3
5082PrPr-F2-Br, 5-NMe3OTf
5083PrPr-F2-Br, 5-NMe3I
5084PrPr-F2-F, 4-Br
5085PrPr-F2-NO2, 4-Br
5086PrPr-F2-NH2, 4-Br
5087PrPr-F2-NHMe, 4-Br
5088PrPr-F2-NMe3, 4-Br
5089PrPr-F2-NMe3OTf, 4-Br
5090PrPr-F2-NMe3I, 4-Br
5091PrPr-F2-I, 4-F
5092PrPr-F2-I, 4-NO2
5093PrPr-F2-I, 4-NH2
5094PrPr-F2-I, 4-NHMe
5095PrPr-F2-I, 4-NMe2
5096PrPr-F2-I, 4-NMe3OTf
5097PrPr-F2-I, 4-NMe3I
5098PrPr-F2-F, 4-I
5099PrPr-F2-NO2, 4-I
5100PrPr-F2-NH2, 4-I
5101PrPr-F2-NHMe, 4-I
5102PrPr-F2-NMe2, 4-I
5103PrPr-F2-NMe3OTf, 4-I
5104PrPr-F2-NMe3I, 4-I
5105PrPr-F2-Me, 3-F
5106PrPr-F2-Me, 3-NO2
5107PrPr-F2-Me, 3-NH2
5108PrPr-F2-Me, 3-NHMe
5109PrPr-F2-Me, 3-NMe2
5110PrPr-F2-Me, 3-NMe3OTf
5111PrPr-F2-Me, 3-NMe3I
5112PrPr-F2-Me, 4-F
5113PrPr-F2-Me, 4-NO2
5114PrPr-F2-Me, 4-NH2
5115PrPr-F2-Me, 4-NHMe
5116PrPr-F2-Me, 4-NMe2
5117PrPr-F2-Me, 4-NMe3OTf
5118PrPr-F2-Me, 4-NMe3I
5119PrPr-F2-Me, 5-F
5120PrPr-F2-Me, 5-NO2
5121PrPr-F2-Me, 5-NH2
5122PrPr-F2-Me, 5-NHMe
5123PrPr-F2-Me, 5-NMe2
5124PrPr-F2-Me, 5-NMe3OTf
5125PrPr-F2-Me, 5-NMe3I
5126PrPr-F2-F, 4-Me
5127PrPr-F2-NO2, 4-Me
5128PrPr-F2-NH2, 4-Me
5129PrPr-F2-NHMe, 4-Me
5130PrPr-F2-NMe2, 4-Me
5131PrPr-F2-NMe3, 4-Me
5132PrPr-F2-NMe3OTf, 4-Me
5133PrPr-F2-NMe3I, 4-Me
5134PrPr-F2-SnMe3, 4-F
5135PrPr-F2-SnMe3, 5-F
5136PrPr-F2-F, 4-SnMe3
5137PrPr-F2-Br, 6-Cl, 4-F
5138PrPr-F2-Br, 6-Cl, 4-NO2
5139PrPr-F2-Br, 6-Cl, 4-NH2
5140PrPr-F2-Br, 6-Cl, 4-NHMe
5141PrPr-F2-Br, 6-Cl, 4-NMe2
5142PrPr-F2-Br, 6-Cl, 4-NMe3OTf
5143PrPr-F2-Br, 6-Cl, 4-NMe3I
5144PrPr-F2-Me, 6-Cl, 4-F
5145PrPr-F2-SnMe3, 6-Cl, 4-F
5146PrPr-F2-Cl, 4-Me
5147PrPr-F2-Cl, 4-Br
5148PrPr-F2-Cl, 4-SnMe3
5149PrPr-F2-Br, 4-Cl
5150PrPr-F2-SnMe3, 4-Cl
5151PrPr-F2-Me, 4-Cl
5152PrPr-F2-Br, 4-Br
5153PrPr-F2-Br, 4-Me
5154PrPr-F2-Br, 4-SnMe3
5155PrPr-F2-SnMe3, 4-Br
5156PrPr-F2-Me, 4-Br
5157PrPr-F2-Me, 4-SnMe3
5158PrPr-F2-SnMe3, 4-Me
5159PrPr-F2-Me, 4-Me
5160PrPr-F2-Et, 4-Br
5161PrPr-F2-Et, 4-SnMe3
5162PrPr-F2-Et, 4-Me
5163PrPr-F2-Me, 4-Me, 6-Me
5164PrPr-F2-Me, 4-Br, 6-Me
5165PrPr-F2-Me, 4-SnMe3, 6-Me
5166PrPr-F2-Et, 6-Me
5167PrPr-F2-Br, 4-i-Pr
5168PrPr-F2-SnMe3, 4-i-Pr
5169PrPr-F2-Me, 4-i-Pr
5170PrPr-F2-Br, 4-Br, 6-Br
5171PrPr-F2-Br, 4-Me, 6-Br
5172PrPr-F2-Br, 4-SnMe3, 6-Br
5173PrPr-F2-SnMe3, 4-Br, 6-Br
5174PrPr-F2-Br, 4-Br, 6-Me
5175PrPr-F2-Br, 4-CF3, 6-Br
5176PrPr-F2-Br, 4-Br, 6-CF3
5177PrPr-F2-CF3, 4-CF3
5178PrPr-F2-Cl, 4-CF3
5179PrPr-F2-CF3, 4-Cl
5180PrPr-F2-Br, 4-CF3
5181PrPr-F2-SnMe3, 4-CF3
5182PrPr-F2-Me, 4-CF3
5183PrPr-F2-CF3, 4-Br
5184PrPr-F2-CF3, 4-SnMe3
5185PrPr-F2-CF3, 4-Me
5186PrPr-F2-Br, 4-OH
5187PrPr-F2-Br, 4-OMe
5188PrPr-F2-Br, 4-OMeF
5189PrPr-F2-Br, 4-OCF3
5190PrPr-F2-Br, 4-OEtF
5191PrPr-F2-Br, 4-OPrF
5192PrPr-F2-OH, 4-Br
5193PrPr-F2-OMe, 4-Br
5194PrPr-F2-OMeF, 4-Br
5195PrPr-F2-OCF3, 4-Br
5196PrPr-F2-OEtF, 4-Br
5197PrPr-F2-OPrF, 4-Br
5198PrPr-F2-I, 4-OH
5199PrPr-F2-I, 4-OMe
5200PrPr-F2-I, 4-OMeF
5201PrPr-F2-I, 4-OCF3
5202PrPr-F2-I, 4-OEtF
5203PrPr-F2-I, 4-OPrF
5204PrPr-F2-OH, 4-I
5205PrPr-F2-OMe, 4-I
5206PrPr-F2-OMeF, 4-I
5207PrPr-F2-OCF3, 4-I
5208PrPr-F2-OEtF, 4-I
5209PrPr-F2-OPrF, 4-I
5210PrPr-F2-SnMe3, 4-OH
5211PrPr-F2-SnMe3, 4-OMe
5212PrPr-F2-SnMe3, 4-OMeF
5213PrPr-F2-SnMe3, 4-OCF3
5214PrPr-F2-SnMe3, 4-OEtF
5215PrPr-F2-SnMe3, 4-OPrF
5216PrPr-F2-OH, 2-SnMe3
5217PrPr-F2-OMe, 4-SnMe3
5218PrPr-F2-OMeF, 4-SnMe3
5219PrPr-F4-OCF3, 4-SnMe3
5220PrPr-F2-OEtF, 4-SnMe3
5221PrPr-F2-OPrF, 4-SnMe3
5222PrEt-FH
5223PrEt-F2-t-Bu
5224PrEt-F2-Br
5225PrEt-F3-Br
5226PrEt-F4-Br
5227PrEt-F2-I
5228PrEt-F3-I
5229PrEt-F4-I
5230PrEt-F2-SnMe3
5231PrEt-F3-SnMe3
5232PrEt-F4-SnMe3
5233PrEt-F2-Me
5234PrEt-F3-Me
5235PrEt-F4-Me
5236PrEt-F2-OH
5237PrEt-F3-OH
5238PrEt-F4-OH
5239PrEt-F2-OMe
5240PrEt-F3-OMe
5241PrEt-F4-OMe
5242PrEt-F2-OMeF
5243PrEt-F3-OMeF
5244PrEt-F4-OMeF
5245PrEt-F2-OCF3
5246PrEt-F3-OCF3
5247PrEt-F4-OCF3
5248PrEt-F2-OEtF
5249PrEt-F3-OEtF
5250PrEt-F4-OEtF
5251PrEt-F2-OPrF
5252PrEt-F3-OPrF
5253PrEt-F4-OPrF
5254PrEt-F2-SH
5255PrEt-F3-SH
5256PrEt-F4-SH
5257PrEt-F2-SMe
5258PrEt-F3-SMe
5259PrEt-F4-SMe
5260PrEt-F2-SMeF
5261PrEt-F3-SMeF
5262PrEt-F4-SMeF
5263PrEt-F2-SCF3
5264PrEt-F3-SCF3
5265PrEt-F4-SCF3
5266PrEt-F2-SEtF
5267PrEt-F3-SEtF
5268PrEt-F4-SEtF
5269PrEt-F2-SPrF
5270PrEt-F3-SPrF
5271PrEt-F4-SPrF
5272PrEt-F2-OMe, 4-OMe
5273PrEt-F2-Me, 5-OH
5274PrEt-F2-Me, 5-OMe
5275PrEt-F2-Me, 5-OMeF
5276PrEt-F2-Me, 5-OEtF
5277PrEt-F2-Me, 5-OPrF
5278PrEt-F2-Me, 4-OH
5279PrEt-F2-Me, 4-OMe
5280PrEt-F2-Me, 4-OMeF
5281PrEt-F2-Me, 4-OCF3
5282PrEt-F2-Me, 4-OEtF
5283PrEt-F2-Me, 4-OPrF
5284PrEt-F2-OH, 4-Me
5285PrEt-F2-OMe, 4-Me
5286PrEt-F2-OMeF, 4-Me
5287PrEt-F2-OCF3, 4-Me
5288PrEt-F2-OEtF, 4-Me
5289PrEt-F2-OPrF, 4-Me
5290PrEt-F2-Cl, 4-OH
5291PrEt-F2-Cl, 4-OMe
5292PrEt-F2-Cl, 4-OMeF
5293PrEt-F2-Cl, 4-OCF3
5294PrEt-F2-Cl, 4-OEtF
5295PrEt-F2-Cl, 4-OPrF
5296PrEt-F2-F, 4-F
5297PrEt-F2-Cl, 4-Cl
5298PrEt-F2-Cl, 4-F
5299PrEt-F2-Cl, 4-NO2
5300PrEt-F2-Cl, 4-NH2
5301PrEt-F2-Cl, 4-NHMe
5302PrEt-F2-Cl, 4-NMe2
5303PrEt-F2-Cl, 4-NMe3OTf
5304PrEt-F2-Cl, 4-NMe3I
5305PrEt-F2-Cl, 5-F
5306PrEt-F2-Cl, 5-NO2
5307PrEt-F2-Cl, 5-NH2
5308PrEt-F2-Cl, 5-NHMe
5309PrEt-F2-Cl, 5-NMe2
5310PrEt-F2-Cl, 5-NMe3OTf
5311PrEt-F2-Cl, 5-NMe3I
5312PrEt-F2-F, 4-Cl
5313PrEt-F2-NO2, 4-Cl
5314PrEt-F2-NH2, 4-Cl
5315PrEt-F2-NHMe, 4-Cl
5316PrEt-F2-NMe2, 4-Cl
5317PrEt-F2-NMe3OTf, 4-Cl
5318PrEt-F2-NMe3I, 4-Cl
5319PrEt-F2-F, 5-Cl
5320PrEt-F2-NO2, 5-Cl
5321PrEt-F2-NH2, 5-Cl
5322PrEt-F2-NHMe, 5-Cl
5323PrEt-F2-NMe2, 5-Cl
5324PrEt-F2-NMe3OTF, 5-Cl
5325PrEt-F2-NMe3I, 5-Cl
5326PrEt-F2-Br, 4-F
5327PrEt-F2-Br, 4-NO2
5328PrEt-F2-Br, 4-NH2
5329PrEt-F2-Br, 4-NHMe
5330PrEt-F2-Br, 4-NMe2
5331PrEt-F2-Br, 4-NMe3OTf
5332PrEt-F2-Br, 4-NMe3I
5333PrEt-F2-Br, 5-F
5334PrEt-F2-Br, 5-NO2
5335PrEt-F2-Br, 5-NH2
5336PrEt-F2-Br, 5-NHMe
5337PrEt-F2-Br, 5-NMe3
5338PrEt-F2-Br, 5-NMe3OTf
5339PrEt-F2-Br, 5-NMe3I
5340PrEt-F2-F, 4-Br
5341PrEt-F2-NO2, 4-Br
5342PrEt-F2-NH2, 4-Br
5343PrEt-F2-NHMe, 4-Br
5344PrEt-F2-NMe3, 4-Br
5345PrEt-F2-NMe3OTf, 4-Br
5346PrEt-F2-NMe3I, 4-Br
5347PrEt-F2-I, 4-F
5348PrEt-F2-I, 4-NO2
5349PrEt-F2-I, 4-NH2
5350PrEt-F2-I, 4-NHMe
5351PrEt-F2-I, 4-NMe2
5352PrEt-F2-I, 4-NMe3OTf
5353PrEt-F2-I, 4-NMe3I
5354PrEt-F2-F, 4-I
5355PrEt-F2-NO2, 4-I
5356PrEt-F2-NH2, 4-I
5357PrEt-F2-NHMe, 4-I
5358PrEt-F2-NMe2, 4-I
5359PrEt-F2-NMe3OTf, 4-I
5360PrEt-F2-NMe3I, 4-I
5361PrEt-F2-Me, 3-F
5362PrEt-F2-Me, 3-NO2
5363PrEt-F2-Me, 3-NH2
5364PrEt-F2-Me, 3-NHMe
5365PrEt-F2-Me, 3-NMe2
5366PrEt-F2-Me, 3-NMe3OTf
5367PrEt-F2-Me, 3-NMe3I
5368PrEt-F2-Me, 4-F
5369PrEt-F2-Me, 4-NO2
5370PrEt-F2-Me, 4-NH2
5371PrEt-F2-Me, 4-NHMe
5372PrEt-F2-Me, 4-NMe2
5373PrEt-F2-Me, 4-NMe3OTf
5374PrEt-F2-Me, 4-NMe3I
5375PrEt-F2-Me, 5-F
5376PrEt-F2-Me, 5-NO2
5377PrEt-F2-Me, 5-NH2
5378PrEt-F2-Me, 5-NHMe
5379PrEt-F2-Me, 5-NMe2
5380PrEt-F2-Me, 5-NMe3OTf
5381PrEt-F2-Me, 5-NMe3I
5382PrEt-F2-F, 4-Me
5383PrEt-F2-NO2, 4-Me
5384PrEt-F2-NH2, 4-Me
5385PrEt-F2-NHMe, 4-Me
5386PrEt-F2-NMe2, 4-Me
5387PrEt-F2-NMe3, 4-Me
5388PrEt-F2-NMe3OTf, 4-Me
5389PrEt-F2-NMe3I, 4-Me
5390PrEt-F2-SnMe3, 4-F
5391PrEt-F2-SnMe3, 5-F
5392PrEt-F2-F, 4-SnMe3
5393PrEt-F2-Br, 6-Cl, 4-F
5394PrEt-F2-Br, 6-Cl, 4-NO2
5395PrEt-F2-Br, 6-Cl, 4-NH2
5396PrEt-F2-Br, 6-Cl, 4-NHMe
5397PrEt-F2-Br, 6-Cl, 4-NMe2
5398PrEt-F2-Br, 6-Cl, 4-NMe3OTf
5399PrEt-F2-Br, 6-Cl, 4-NMe3I
5400PrEt-F2-Me, 6-Cl, 4-F
5401PrEt-F2-SnMe3, 6-Cl, 4-F
5402PrEt-F2-Cl, 4-Me
5403PrEt-F2-Cl, 4-Br
5404PrEt-F2-Cl, 4-SnMe3
5405PrEt-F2-Br, 4-Cl
5406PrEt-F2-SnMe3, 4-Cl
5407PrEt-F2-Me, 4-Cl
5408PrEt-F2-Br, 4-Br
5409PrEt-F2-Br, 4-Me
5410PrEt-F2-Br, 4-SnMe3
5411PrEt-F2-SnMe3, 4-Br
5412PrEt-F2-Me, 4-Br
5413PrEt-F2-Me, 4-SnMe3
5414PrEt-F2-SnMe3, 4-Me
5415PrEt-F2-Me, 4-Me
5416PrEt-F2-Et, 4-Br
5417PrEt-F2-Et, 4-SnMe3
5418PrEt-F2-Et, 4-Me
5419PrEt-F2-Me, 4-Me, 6-Me
5420PrEt-F2-Me, 4-Br, 6-Me
5421PrEt-F2-Me, 4-SnMe3, 6-Me
5422PrEt-F2-Et, 6-Me
5423PrEt-F2-Br, 4-i-Pr
5424PrEt-F2-SnMe3, 4-i-Pr
5425PrEt-F2-Me, 4-i-Pr
5426PrEt-F2-Br, 4-Br, 6-Br
5427PrEt-F2-Br, 4-Me, 6-Br
5428PrEt-F2-Br, 4-SnMe3, 6-Br
5429PrEt-F2-SnMe3, 4-Br, 6-Br
5430PrEt-F2-Br, 4-Br, 6-Me
5431PrEt-F2-Br, 4-CF3, 6-Br
5432PrEt-F2-Br, 4-Br, 6-CF3
5433PrEt-F2-CF3, 4-CF3
5434PrEt-F2-Cl, 4-CF3
5435PrEt-F2-CF3, 4-Cl
5436PrEt-F2-Br, 4-CF3
5437PrEt-F2-SnMe3, 4-CF3
5438PrEt-F2-Me, 4-CF3
5439PrEt-F2-CF3, 4-Br
5440PrEt-F2-CF3, 4-SnMe3
5441PrEt-F2-CF3, 4-Me
5442PrEt-F2-Br, 4-OH
5443PrEt-F2-Br, 4-OMe
5444PrEt-F2-Br, 4-OMeF
5445PrEt-F2-Br, 4-OCF3
5446PrEt-F2-Br, 4-OEtF
5447PrEt-F2-Br, 4-OPrF
5448PrEt-F2-OH, 4-Br
5449PrEt-F2-OMe, 4-Br
5450PrEt-F2-OMeF, 4-Br
5451PrEt-F2-OCF3, 4-Br
5452PrEt-F2-OEtF, 4-Br
5453PrEt-F2-OPrF, 4-Br
5454PrEt-F2-I, 4-OH
5455PrEt-F2-I, 4-OMe
5456PrEt-F2-I, 4-OMeF
5457PrEt-F2-I, 4-OCF3
5458PrEt-F2-I, 4-OEtF
5459PrEt-F2-I, 4-OPrF
5460PrEt-F2-OH, 4-I
5461PrEt-F2-OMe, 4-I
5462PrEt-F2-OMeF, 4-I
5463PrEt-F2-OCF3, 4-I
5464PrEt-F2-OEtF, 4-I
5465PrEt-F2-OPrF, 4-I
5466PrEt-F2-SnMe3, 4-OH
5467PrEt-F2-SnMe3, 4-OMe
5468PrEt-F2-SnMe3, 4-OMeF
5469PrEt-F2-SnMe3, 4-OCF3
5470PrEt-F2-SnMe3, 4-OEtF
5471PrEt-F2-SnMe3, 4-OPrF
5472PrEt-F2-OH, 2-SnMe3
5473PrEt-F2-OMe, 4-SnMe3
5474PrEt-F2-OMeF, 4-SnMe3
5475PrEt-F4-OCF3, 4-SnMe3
5476PrEt-F2-OEtF, 4-SnMe3
5477PrEt-F2-OPrF, 4-SnMe3
5478Pr-FEtH
5479Pr-FEt2-t-Bu
5480Pr-FEt2-Br
5481Pr-FEt3-Br
5482Pr-FEt4-Br
5483Pr-FEt2-I
5484Pr-FEt3-I
5485Pr-FEt4-I
5486Pr-FEt2-SnMe3
5487Pr-FEt3-SnMe3
5488Pr-FEt4-SnMe3
5489Pr-FEt2-Me
5490Pr-FEt3-Me
5491Pr-FEt4-Me
5492Pr-FEt2-OH
5493Pr-FEt3-OH
5494Pr-FEt4-OH
5495Pr-FEt2-OMe
5496Pr-FEt3-OMe
5497Pr-FEt4-OMe
5498Pr-FEt2-OMeF
5499Pr-FEt3-OMeF
5500Pr-FEt4-OMeF
5501Pr-FEt2-OCF3
5502Pr-FEt3-OCF3
5503Pr-FEt4-OCF3
5504Pr-FEt2-OEtF
5505Pr-FEt3-OEtF
5506Pr-FEt4-OEtF
5507Pr-FEt2-OPrF
5508Pr-FEt3-OPrF
5509Pr-FEt4-OPrF
5510Pr-FEt2-SH
5511Pr-FEt3-SH
5512Pr-FEt4-SH
5513Pr-FEt2-SMe
5514Pr-FEt3-SMe
5515Pr-FEt4-SMe
5516Pr-FEt2-SMeF
5517Pr-FEt3-SMeF
5518Pr-FEt4-SMeF
5519Pr-FEt2-SCF3
5520Pr-FEt3-SCF3
5521Pr-FEt4-SCF3
5522Pr-FEt2-SEtF
5523Pr-FEt3-SEtF
5524Pr-FEt4-SEtF
5525Pr-FEt2-SPrF
5526Pr-FEt3-SPrF
5527Pr-FEt4-SPrF
5528Pr-FEt2-OMe, 4-OMe
5529Pr-FEt2-Me, 5-OH
5530Pr-FEt2-Me, 5-OMe
5531Pr-FEt2-Me, 5-OMeF
5532Pr-FEt2-Me, 5-OEtF
5533Pr-FEt2-Me, 5-OPrF
5534Pr-FEt2-Me, 4-OH
5535Pr-FEt2-Me, 4-OMe
5536Pr-FEt2-Me, 4-OMeF
5537Pr-FEt2-Me, 4-OCF3
5538Pr-FEt2-Me, 4-OEtF
5539Pr-FEt2-Me, 4-OPrF
5540Pr-FEt2-OH, 4-Me
5541Pr-FEt2-OMe, 4-Me
5542Pr-FEt2-OMeF, 4-Me
5543Pr-FEt2-OCF3, 4-Me
5544Pr-FEt2-OEtF, 4-Me
5545Pr-FEt2-OPrF, 4-Me
5546Pr-FEt2-Cl, 4-OH
5547Pr-FEt2-Cl, 4-OMe
5548Pr-FEt2-Cl, 4-OMeF
5549Pr-FEt2-Cl, 4-OCF3
5550Pr-FEt2-Cl, 4-OEtF
5551Pr-FEt2-Cl, 4-OPrF
5552Pr-FEt2-F, 4-F
5553Pr-FEt2-Cl, 4-Cl
5554Pr-FEt2-Cl, 4-F
5555Pr-FEt2-Cl, 4-NO2
5556Pr-FEt2-Cl, 4-NH2
5557Pr-FEt2-Cl, 4-NHMe
5558Pr-FEt2-Cl, 4-NMe2
5559Pr-FEt2-Cl, 4-NMe3OTf
5560Pr-FEt2-Cl, 4-NMe3I
5561Pr-FEt2-Cl, 5-F
5562Pr-FEt2-Cl, 5-NO2
5563Pr-FEt2-Cl, 5-NH2
5564Pr-FEt2-Cl, 5-NHMe
5565Pr-FEt2-Cl, 5-NMe2
5566Pr-FEt2-Cl, 5-NMe3OTf
5567Pr-FEt2-Cl, 5-NMe3I
5568Pr-FEt2-F, 4-Cl
5569Pr-FEt2-NO2, 4-Cl
5570Pr-FEt2-NH2, 4-Cl
5571Pr-FEt2-NHMe, 4-Cl
5572Pr-FEt2-NMe2, 4-Cl
5573Pr-FEt2-NMe3OTf, 4-Cl
5574Pr-FEt2-NMe3I, 4-Cl
5575Pr-FEt2-F, 5-Cl
5576Pr-FEt2-NO2, 5-Cl
5577Pr-FEt2-NH2, 5-Cl
5578Pr-FEt2-NHMe, 5-Cl
5579Pr-FEt2-NMe2, 5-Cl
5580Pr-FEt2-NMe3OTF, 5-Cl
5581Pr-FEt2-NMe3I, 5-Cl
5582Pr-FEt2-Br, 4-F
5583Pr-FEt2-Br, 4-NO2
5584Pr-FEt2-Br, 4-NH2
5585Pr-FEt2-Br, 4-NHMe
5586Pr-FEt2-Br, 4-NMe2
5587Pr-FEt2-Br, 4-NMe3OTf
5588Pr-FEt2-Br, 4-NMe3I
5589Pr-FEt2-Br, 5-F
5590Pr-FEt2-Br, 5-NO2
5591Pr-FEt2-Br, 5-NH2
5592Pr-FEt2-Br, 5-NHMe
5593Pr-FEt2-Br, 5-NMe3
5594Pr-FEt2-Br, 5-NMe3OTf
5595Pr-FEt2-Br, 5-NMe3I
5596Pr-FEt2-F, 4-Br
5597Pr-FEt2-NO2, 4-Br
5598Pr-FEt2-NH2, 4-Br
5599Pr-FEt2-NHMe, 4-Br
5600Pr-FEt2-NMe3, 4-Br
5601Pr-FEt2-NMe3OTf, 4-Br
5602Pr-FEt2-NMe3I, 4-Br
5603Pr-FEt2-I, 4-F
5604Pr-FEt2-I, 4-NO2
5605Pr-FEt2-I, 4-NH2
5606Pr-FEt2-I, 4-NHMe
5607Pr-FEt2-I, 4-NMe2
5608Pr-FEt2-I, 4-NMe3OTf
5609Pr-FEt2-I, 4-NMe3I
5610Pr-FEt2-F, 4-I
5611Pr-FEt2-NO2, 4-I
5612Pr-FEt2-NH2, 4-I
5613Pr-FEt2-NHMe, 4-I
5614Pr-FEt2-NMe2, 4-I
5615Pr-FEt2-NMe3OTf, 4-I
5616Pr-FEt2-NMe3I, 4-I
5617Pr-FEt2-Me, 3-F
5618Pr-FEt2-Me, 3-NO2
5619Pr-FEt2-Me, 3-NH2
5620Pr-FEt2-Me, 3-NHMe
5621Pr-FEt2-Me, 3-NMe2
5622Pr-FEt2-Me, 3-NMe3OTf
5623Pr-FEt2-Me, 3-NMe3I
5624Pr-FEt2-Me, 4-F
5625Pr-FEt2-Me, 4-NO2
5626Pr-FEt2-Me, 4-NH2
5627Pr-FEt2-Me, 4-NHMe
5628Pr-FEt2-Me, 4-NMe2
5629Pr-FEt2-Me, 4-NMe3OTf
5630Pr-FEt2-Me, 4-NMe3I
5631Pr-FEt2-Me, 5-F
5632Pr-FEt2-Me, 5-NO2
5633Pr-FEt2-Me, 5-NH2
5634Pr-FEt2-Me, 5-NHMe
5635Pr-FEt2-Me, 5-NMe2
5636Pr-FEt2-Me, 5-NMe3OTf
5637Pr-FEt2-Me, 5-NMe3I
5638Pr-FEt2-F, 4-Me
5639Pr-FEt2-NO2, 4-Me
5640Pr-FEt2-NH2, 4-Me
5641Pr-FEt2-NHMe, 4-Me
5642Pr-FEt2-NMe2, 4-Me
5643Pr-FEt2-NMe3, 4-Me
5644Pr-FEt2-NMe3OTf, 4-Me
5645Pr-FEt2-NMe3I, 4-Me
5646Pr-FEt2-SnMe3, 4-F
5647Pr-FEt2-SnMe3, 5-F
5648Pr-FEt2-F, 4-SnMe3
5649Pr-FEt2-Br, 6-Cl, 4-F
5650Pr-FEt2-Br, 6-Cl, 4-NO2
5651Pr-FEt2-Br, 6-Cl, 4-NH2
5652Pr-FEt2-Br, 6-Cl, 4-NHMe
5653Pr-FEt2-Br, 6-Cl, 4-NMe2
5654Pr-FEt2-Br, 6-Cl, 4-NMe3OTf
5655Pr-FEt2-Br, 6-Cl, 4-NMe3I
5656Pr-FEt2-Me, 6-Cl, 4-F
5657Pr-FEt2-SnMe3, 6-Cl, 4-F
5658Pr-FEt2-Cl, 4-Me
5659Pr-FEt2-Cl, 4-Br
5660Pr-FEt2-Cl, 4-SnMe3
5661Pr-FEt2-Br, 4-Cl
5662Pr-FEt2-SnMe3, 4-Cl
5663Pr-FEt2-Me, 4-Cl
5664Pr-FEt2-Br, 4-Br
5665Pr-FEt2-Br, 4-Me
5666Pr-FEt2-Br, 4-SnMe3
5667Pr-FEt2-SnMe3, 4-Br
5668Pr-FEt2-Me, 4-Br
5669Pr-FEt2-Me, 4-SnMe3
5670Pr-FEt2-SnMe3, 4-Me
5671Pr-FEt2-Me, 4-Me
5672Pr-FEt2-Et, 4-Br
5673Pr-FEt2-Et, 4-SnMe3
5674Pr-FEt2-Et, 4-Me
5675Pr-FEt2-Me, 4-Me, 6-Me
5676Pr-FEt2-Me, 4-Br, 6-Me
5677Pr-FEt2-Me, 4-SnMe3, 6-Me
5678Pr-FEt2-Et, 6-Me
5679Pr-FEt2-Br, 4-i-Pr
5680Pr-FEt2-SnMe3, 4-i-Pr
5681Pr-FEt2-Me, 4-i-Pr
5682Pr-FEt2-Br, 4-Br, 6-Br
5683Pr-FEt2-Br, 4-Me, 6-Br
5684Pr-FEt2-Br, 4-SnMe3, 6-Br
5685Pr-FEt2-SnMe3, 4-Br, 6-Br
5686Pr-FEt2-Br, 4-Br, 6-Me
5687Pr-FEt2-Br, 4-CF3, 6-Br
5688Pr-FEt2-Br, 4-Br, 6-CF3
5689Pr-FEt2-CF3, 4-CF3
5690Pr-FEt2-Cl, 4-CF3
5691Pr-FEt2-CF3, 4-Cl
5692Pr-FEt2-Br, 4-CF3
5693Pr-FEt2-SnMe3, 4-CF3
5694Pr-FEt2-Me, 4-CF3
5695Pr-FEt2-CF3, 4-Br
5696Pr-FEt2-CF3, 4-SnMe3
5697Pr-FEt2-CF3, 4-Me
5698Pr-FEt2-Br, 4-OH
5699Pr-FEt2-Br, 4-OMe
5700Pr-FEt2-Br, 4-OMeF
5701Pr-FEt2-Br, 4-OCF3
5702Pr-FEt2-Br, 4-OEtF
5703Pr-FEt2-Br, 4-OPrF
5704Pr-FEt2-OH, 4-Br
5705Pr-FEt2-OMe, 4-Br
5706Pr-FEt2-OMeF, 4-Br
5707Pr-FEt2-OCF3, 4-Br
5708Pr-FEt2-OEtF, 4-Br
5709Pr-FEt2-OPrF, 4-Br
5710Pr-FEt2-I, 4-OH
5711Pr-FEt2-I, 4-OMe
5712Pr-FEt2-I, 4-OMeF
5713Pr-FEt2-I, 4-OCF3
5714Pr-FEt2-I, 4-OEtF
5715Pr-FEt2-I, 4-OPrF
5716Pr-FEt2-OH, 4-I
5717Pr-FEt2-OMe, 4-I
5718Pr-FEt2-OMeF, 4-I
5719Pr-FEt2-OCF3, 4-I
5720Pr-FEt2-OEtF, 4-I
5721Pr-FEt2-OPrF, 4-I
5722Pr-FEt2-SnMe3, 4-OH
5723Pr-FEt2-SnMe3, 4-OMe
5724Pr-FEt2-SnMe3, 4-OMeF
5725Pr-FEt2-SnMe3, 4-OCF3
5726Pr-FEt2-SnMe3, 4-OEtF
5727Pr-FEt2-SnMe3, 4-OPrF
5728Pr-FEt2-OH, 2-SnMe3
5729Pr-FEt2-OMe, 4-SnMe3
5730Pr-FEt2-OMeF, 4-SnMe3
5731Pr-FEt4-OCF3, 4-SnMe3
5732Pr-FEt2-OEtF, 4-SnMe3
5733Pr-FEt2-OPrF, 4-SnMe3
5734BuEt-FH
5735BuEt-F2-t-Bu
5736BuEt-F2-Br
5737BuEt-F3-Br
5738BuEt-F4-Br
5739BuEt-F2-I
5740BuEt-F3-I
5741BuEt-F4-I
5742BuEt-F2-SnMe3
5743BuEt-F3-SnMe3
5744BuEt-F4-SnMe3
5745BuEt-F2-Me
5746BuEt-F3-Me
5747BuEt-F4-Me
5748BuEt-F2-OH
5749BuEt-F3-OH
5750BuEt-F4-OH
5751BuEt-F2-OMe
5752BuEt-F3-OMe
5753BuEt-F4-OMe
5754BuEt-F2-OMeF
5755BuEt-F3-OMeF
5756BuEt-F4-OMeF
5757BuEt-F2-OCF3
5758BuEt-F3-OCF3
5759BuEt-F4-OCF3
5760BuEt-F2-OEtF
5761BuEt-F3-OEtF
5762BuEt-F4-OEtF
5763BuEt-F2-OPrF
5764BuEt-F3-OPrF
5765BuEt-F4-OPrF
5766BuEt-F2-SH
5767BuEt-F3-SH
5768BuEt-F4-SH
5769BuEt-F2-SMe
5770BuEt-F3-SMe
5771BuEt-F4-SMe
5772BuEt-F2-SMeF
5773BuEt-F3-SMeF
5774BuEt-F4-SMeF
5775BuEt-F2-SCF3
5776BuEt-F3-SCF3
5777BuEt-F4-SCF3
5778BuEt-F2-SEtF
5779BuEt-F3-SEtF
5780BuEt-F4-SEtF
5781BuEt-F2-SPrF
5782BuEt-F3-SPrF
5783BuEt-F4-SPrF
5784BuEt-F2-OMe, 4-OMe
5785BuEt-F2-Me, 5-OH
5786BuEt-F2-Me, 5-OMe
5787BuEt-F2-Me, 5-OMeF
5788BuEt-F2-Me, 5-OEtF
5789BuEt-F2-Me, 5-OPrF
5790BuEt-F2-Me, 4-OH
5791BuEt-F2-Me, 4-OMe
5792BuEt-F2-Me, 4-OMeF
5793BuEt-F2-Me, 4-OCF3
5794BuEt-F2-Me, 4-OEtF
5795BuEt-F2-Me, 4-OPrF
5796BuEt-F2-OH, 4-Me
5797BuEt-F2-OMe, 4-Me
5798BuEt-F2-OMeF, 4-Me
5799BuEt-F2-OCF3, 4-Me
5800BuEt-F2-OEtF, 4-Me
5801BuEt-F2-OPrF, 4-Me
5802BuEt-F2-Cl, 4-OH
5803BuEt-F2-Cl, 4-OMe
5804BuEt-F2-Cl, 4-OMeF
5805BuEt-F2-Cl, 4-OCF3
5806BuEt-F2-Cl, 4-OEtF
5807BuEt-F2-Cl, 4-OPrF
5808BuEt-F2-F, 4-F
5809BuEt-F2-Cl, 4-Cl
5810BuEt-F2-Cl, 4-F
5811BuEt-F2-Cl, 4-NO2
5812BuEt-F2-Cl, 4-NH2
5813BuEt-F2-Cl, 4-NHMe
5814BuEt-F2-Cl, 4-NMe2
5815BuEt-F2-Cl, 4-NMe3OTf
5816BuEt-F2-Cl, 4-NMe3I
5817BuEt-F2-Cl, 5-F
5818BuEt-F2-Cl, 5-NO2
5819BuEt-F2-Cl, 5-NH2
5820BuEt-F2-Cl, 5-NHMe
5821BuEt-F2-Cl, 5-NMe2
5822BuEt-F2-Cl, 5-NMe3OTf
5823BuEt-F2-Cl, 5-NMe3I
5824BuEt-F2-F, 4-Cl
5825BuEt-F2-NO2, 4-Cl
5826BuEt-F2-NH2, 4-Cl
5827BuEt-F2-NHMe, 4-Cl
5828BuEt-F2-NMe2, 4-Cl
5829BuEt-F2-NMe3OTf, 4-Cl
5830BuEt-F2-NMe3I, 4-Cl
5831BuEt-F2-F, 5-Cl
5832BuEt-F2-NO2, 5-Cl
5833BuEt-F2-NH2, 5-Cl
5834BuEt-F2-NHMe, 5-Cl
5835BuEt-F2-NMe2, 5-Cl
5836BuEt-F2-NMe3OTF, 5-Cl
5837BuEt-F2-NMe3I, 5-Cl
5838BuEt-F2-Br, 4-F
5839BuEt-F2-Br, 4-NO2
5840BuEt-F2-Br, 4-NH2
5841BuEt-F2-Br, 4-NHMe
5842BuEt-F2-Br, 4-NMe2
5843BuEt-F2-Br, 4-NMe3OTf
5844BuEt-F2-Br, 4-NMe3I
5845BuEt-F2-Br, 5-F
5846BuEt-F2-Br, 5-NO2
5847BuEt-F2-Br, 5-NH2
5848BuEt-F2-Br, 5-NHMe
5849BuEt-F2-Br, 5-NMe3
5850BuEt-F2-Br, 5-NMe3OTf
5851BuEt-F2-Br, 5-NMe3I
5852BuEt-F2-F, 4-Br
5853BuEt-F2-NO2, 4-Br
5854BuEt-F2-NH2, 4-Br
5855BuEt-F2-NHMe, 4-Br
5856BuEt-F2-NMe3, 4-Br
5857BuEt-F2-NMe3OTf, 4-Br
5858BuEt-F2-NMe3I, 4-Br
5859BuEt-F2-I, 4-F
5860BuEt-F2-I, 4-NO2
5861BuEt-F2-I, 4-NH2
5862BuEt-F2-I, 4-NHMe
5863BuEt-F2-I, 4-NMe2
5864BuEt-F2-I, 4-NMe3OTf
5865BuEt-F2-I, 4-NMe3I
5866BuEt-F2-F, 4-I
5867BuEt-F2-NO2, 4-I
5868BuEt-F2-NH2, 4-I
5869BuEt-F2-NHMe, 4-I
5870BuEt-F2-NMe2, 4-I
5871BuEt-F2-NMe3OTf, 4-I
5872BuEt-F2-NMe3I, 4-I
5873BuEt-F2-Me, 3-F
5874BuEt-F2-Me, 3-NO2
5875BuEt-F2-Me, 3-NH2
5876BuEt-F2-Me, 3-NHMe
5877BuEt-F2-Me, 3-NMe2
5878BuEt-F2-Me, 3-NMe3OTf
5879BuEt-F2-Me, 3-NMe3I
5880BuEt-F2-Me, 4-F
5881BuEt-F2-Me, 4-NO2
5882BuEt-F2-Me, 4-NH2
5883BuEt-F2-Me, 4-NHMe
5884BuEt-F2-Me, 4-NMe2
5885BuEt-F2-Me, 4-NMe3OTf
5886BuEt-F2-Me, 4-NMe3I
5887BuEt-F2-Me, 5-F
5888BuEt-F2-Me, 5-NO2
5889BuEt-F2-Me, 5-NH2
5890BuEt-F2-Me, 5-NHMe
5891BuEt-F2-Me, 5-NMe2
5892BuEt-F2-Me, 5-NMe3OTf
5893BuEt-F2-Me, 5-NMe3I
5894BuEt-F2-F, 4-Me
5895BuEt-F2-NO2, 4-Me
5896BuEt-F2-NH2, 4-Me
5897BuEt-F2-NHMe, 4-Me
5898BuEt-F2-NMe2, 4-Me
5899BuEt-F2-NMe3, 4-Me
5900BuEt-F2-NMe3OTf, 4-Me
5901BuEt-F2-NMe3I, 4-Me
5902BuEt-F2-SnMe3, 4-F
5903BuEt-F2-SnMe3, 5-F
5904BuEt-F2-F, 4-SnMe3
5905BuEt-F2-Br, 6-Cl, 4-F
5906BuEt-F2-Br, 6-Cl, 4-NO2
5907BuEt-F2-Br, 6-Cl, 4-NH2
5908BuEt-F2-Br, 6-Cl, 4-NHMe
5909BuEt-F2-Br, 6-Cl, 4-NMe2
5910BuEt-F2-Br, 6-Cl, 4-NMe3OTf
5911BuEt-F2-Br, 6-Cl, 4-NMe3I
5912BuEt-F2-Me, 6-Cl, 4-F
5913BuEt-F2-SnMe3, 6-Cl, 4-F
5914BuEt-F2-Cl, 4-Me
5915BuEt-F2-Cl, 4-Br
5916BuEt-F2-Cl, 4-SnMe3
5917BuEt-F2-Br, 4-Cl
5918BuEt-F2-SnMe3, 4-Cl
5919BuEt-F2-Me, 4-Cl
5920BuEt-F2-Br, 4-Br
5921BuEt-F2-Br, 4-Me
5922BuEt-F2-Br, 4-SnMe3
5923BuEt-F2-SnMe3, 4-Br
5924BuEt-F2-Me, 4-Br
5925BuEt-F2-Me, 4-SnMe3
5926BuEt-F2-SnMe3, 4-Me
5927BuEt-F2-Me, 4-Me
5928BuEt-F2-Et, 4-Br
5929BuEt-F2-Et, 4-SnMe3
5930BuEt-F2-Et, 4-Me
5931BuEt-F2-Me, 4-Me, 6-Me
5932BuEt-F2-Me, 4-Br, 6-Me
5933BuEt-F2-Me, 4-SnMe3, 6-Me
5934BuEt-F2-Et, 6-Me
5935BuEt-F2-Br, 4-i-Pr
5936BuEt-F2-SnMe3, 4-i-Pr
5937BuEt-F2-Me, 4-i-Pr
5938BuEt-F2-Br, 4-Br, 6-Br
5939BuEt-F2-Br, 4-Me, 6-Br
5940BuEt-F2-Br, 4-SnMe3, 6-Br
5941BuEt-F2-SnMe3, 4-Br, 6-Br
5942BuEt-F2-Br, 4-Br, 6-Me
5943BuEt-F2-Br, 4-CF3, 6-Br
5944BuEt-F2-Br, 4-Br, 6-CF3
5945BuEt-F2-CF3, 4-CF3
5946BuEt-F2-Cl, 4-CF3
5947BuEt-F2-CF3, 4-Cl
5948BuEt-F2-Br, 4-CF3
5949BuEt-F2-SnMe3, 4-CF3
5950BuEt-F2-Me, 4-CF3
5951BuEt-F2-CF3, 4-Br
5952BuEt-F2-CF3, 4-SnMe3
5953BuEt-F2-CF3, 4-Me
5954BuEt-F2-Br, 4-OH
5955BuEt-F2-Br, 4-OMe
5956BuEt-F2-Br, 4-OMeF
5957BuEt-F2-Br, 4-OCF3
5958BuEt-F2-Br, 4-OEtF
5959BuEt-F2-Br, 4-OPrF
5960BuEt-F2-OH, 4-Br
5961BuEt-F2-OMe, 4-Br
5962BuEt-F2-OMeF, 4-Br
5963BuEt-F2-OCF3, 4-Br
5964BuEt-F2-OEtF, 4-Br
5965BuEt-F2-OPrF, 4-Br
5966BuEt-F2-I, 4-OH
5967BuEt-F2-I, 4-OMe
5968BuEt-F2-I, 4-OMeF
5969BuEt-F2-I, 4-OCF3
5970BuEt-F2-I, 4-OEtF
5971BuEt-F2-I, 4-OPrF
5972BuEt-F2-OH, 4-I
5973BuEt-F2-OMe, 4-I
5974BuEt-F2-OMeF, 4-I
5975BuEt-F2-OCF3, 4-I
5976BuEt-F2-OEtF, 4-I
5977BuEt-F2-OPrF, 4-I
5978BuEt-F2-SnMe3, 4-OH
5979BuEt-F2-SnMe3, 4-OMe
5980BuEt-F2-SnMe3, 4-OMeF
5981BuEt-F2-SnMe3, 4-OCF3
5982BuEt-F2-SnMe3, 4-OEtF
5983BuEt-F2-SnMe3, 4-OPrF
5984BuEt-F2-OH, 2-SnMe3
5985BuEt-F2-OMe, 4-SnMe3
5986BuEt-F2-OMeF, 4-SnMe3
5987BuEt-F4-OCF3, 4-SnMe3
5988BuEt-F2-OEtF, 4-SnMe3
5989BuEt-F2-OPrF, 4-SnMe3
5990Bu-FEtH
5991Bu-FEt2-t-Bu
5992Bu-FEt2-Br
5993Bu-FEt3-Br
5994Bu-FEt4-Br
5995Bu-FEt2-I
5996Bu-FEt3-I
5997Bu-FEt4-I
5998Bu-FEt2-SnMe3
5999Bu-FEt3-SnMe3
6000Bu-FEt4-SnMe3
6001Bu-FEt2-Me
6002Bu-FEt3-Me
6003Bu-FEt4-Me
6004Bu-FEt2-OH
6005Bu-FEt3-OH
6006Bu-FEt4-OH
6007Bu-FEt2-OMe
6008Bu-FEt3-OMe
6009Bu-FEt4-OMe
6010Bu-FEt2-OMeF
6011Bu-FEt3-OMeF
6012Bu-FEt4-OMeF
6013Bu-FEt2-OCF3
6014Bu-FEt3-OCF3
6015Bu-FEt4-OCF3
6016Bu-FEt2-OEtF
6017Bu-FEt3-OEtF
6018Bu-FEt4-OEtF
6019Bu-FEt2-OPrF
6020Bu-FEt3-OPrF
6021Bu-FEt4-OPrF
6022Bu-FEt2-SH
6023Bu-FEt3-SH
6024Bu-FEt4-SH
6025Bu-FEt2-SMe
6026Bu-FEt3-SMe
6027Bu-FEt4-SMe
6028Bu-FEt2-SMeF
6029Bu-FEt3-SMeF
6030Bu-FEt4-SMeF
6031Bu-FEt2-SCF3
6032Bu-FEt3-SCF3
6033Bu-FEt4-SCF3
6034Bu-FEt2-SEtF
6035Bu-FEt3-SEtF
6036Bu-FEt4-SEtF
6037Bu-FEt2-SPrF
6038Bu-FEt3-SPrF
6039Bu-FEt4-SPrF
6040Bu-FEt2-OMe, 4-OMe
6041Bu-FEt2-Me, 5-OH
6042Bu-FEt2-Me, 5-OMe
6043Bu-FEt2-Me, 5-OMeF
6044Bu-FEt2-Me, 5-OEtF
6045Bu-FEt2-Me, 5-OPrF
6046Bu-FEt2-Me, 4-OH
6047Bu-FEt2-Me, 4-OMe
6048Bu-FEt2-Me, 4-OMeF
6049Bu-FEt2-Me, 4-OCF3
6050Bu-FEt2-Me, 4-OEtF
6051Bu-FEt2-Me, 4-OPrF
6052Bu-FEt2-OH, 4-Me
6053Bu-FEt2-OMe, 4-Me
6054Bu-FEt2-OMeF, 4-Me
6055Bu-FEt2-OCF3, 4-Me
6056Bu-FEt2-OEtF, 4-Me
6057Bu-FEt2-OPrF, 4-Me
6058Bu-FEt2-Cl, 4-OH
6059Bu-FEt2-Cl, 4-OMe
6060Bu-FEt2-Cl, 4-OMeF
6061Bu-FEt2-Cl, 4-OCF3
6062Bu-FEt2-Cl, 4-OEtF
6063Bu-FEt2-Cl, 4-OPrF
6064Bu-FEt2-F, 4-F
6065Bu-FEt2-Cl, 4-Cl
6066Bu-FEt2-Cl, 4-F
6067Bu-FEt2-Cl, 4-NO2
6068Bu-FEt2-Cl, 4-NH2
6069Bu-FEt2-Cl, 4-NHMe
6070Bu-FEt2-Cl, 4-NMe2
6071Bu-FEt2-Cl, 4-NMe3OTf
6072Bu-FEt2-Cl, 4-NMe3I
6073Bu-FEt2-Cl, 5-F
6074Bu-FEt2-Cl, 5-NO2
6075Bu-FEt2-Cl, 5-NH2
6076Bu-FEt2-Cl, 5-NHMe
6077Bu-FEt2-Cl, 5-NMe2
6078Bu-FEt2-Cl, 5-NMe3OTf
6079Bu-FEt2-Cl, 5-NMe3I
6080Bu-FEt2-F, 4-Cl
6081Bu-FEt2-NO2, 4-Cl
6082Bu-FEt2-NH2, 4-Cl
6083Bu-FEt2-NHMe, 4-Cl
6084Bu-FEt2-NMe2, 4-Cl
6085Bu-FEt2-NMe3OTf, 4-Cl
6086Bu-FEt2-NMe3I, 4-Cl
6087Bu-FEt2-F, 5-Cl
6088Bu-FEt2-NO2, 5-Cl
6089Bu-FEt2-NH2, 5-Cl
6090Bu-FEt2-NHMe, 5-Cl
6091Bu-FEt2-NMe2, 5-Cl
6092Bu-FEt2-NMe3OTF, 5-Cl
6093Bu-FEt2-NMe3I, 5-Cl
6094Bu-FEt2-Br, 4-F
6095Bu-FEt2-Br, 4-NO2
6096Bu-FEt2-Br, 4-NH2
6097Bu-FEt2-Br, 4-NHMe
6098Bu-FEt2-Br, 4-NMe2
6099Bu-FEt2-Br, 4-NMe3OTf
6100Bu-FEt2-Br, 4-NMe3I
6101Bu-FEt2-Br, 5-F
6102Bu-FEt2-Br, 5-NO2
6103Bu-FEt2-Br, 5-NH2
6104Bu-FEt2-Br, 5-NHMe
6105Bu-FEt2-Br, 5-NMe3
6106Bu-FEt2-Br, 5-NMe3OTf
6107Bu-FEt2-Br, 5-NMe3I
6108Bu-FEt2-F, 4-Br
6109Bu-FEt2-NO2, 4-Br
6110Bu-FEt2-NH2, 4-Br
6111Bu-FEt2-NHMe, 4-Br
6112Bu-FEt2-NMe3, 4-Br
6113Bu-FEt2-NMe3OTf, 4-Br
6114Bu-FEt2-NMe3I, 4-Br
6115Bu-FEt2-I, 4-F
6116Bu-FEt2-I, 4-NO2
6117Bu-FEt2-I, 4-NH2
6118Bu-FEt2-I, 4-NHMe
6119Bu-FEt2-I, 4-NMe2
6120Bu-FEt2-I, 4-NMe3OTf
6121Bu-FEt2-I, 4-NMe3I
6122Bu-FEt2-F, 4-I
6123Bu-FEt2-NO2, 4-I
6124Bu-FEt2-NH2, 4-I
6125Bu-FEt2-NHMe, 4-I
6126Bu-FEt2-NMe2, 4-I
6127Bu-FEt2-NMe3OTf, 4-I
6128Bu-FEt2-NMe3I, 4-I
6129Bu-FEt2-Me, 3-F
6130Bu-FEt2-Me, 3-NO2
6131Bu-FEt2-Me, 3-NH2
6132Bu-FEt2-Me, 3-NHMe
6133Bu-FEt2-Me, 3-NMe2
6134Bu-FEt2-Me, 3-NMe3OTf
6135Bu-FEt2-Me, 3-NMe3I
6136Bu-FEt2-Me, 4-F
6137Bu-FEt2-Me, 4-NO2
6138Bu-FEt2-Me, 4-NH2
6139Bu-FEt2-Me, 4-NHMe
6140Bu-FEt2-Me, 4-NMe2
6141Bu-FEt2-Me, 4-NMe3OTf
6142Bu-FEt2-Me, 4-NMe3I
6143Bu-FEt2-Me, 5-F
6144Bu-FEt2-Me, 5-NO2
6145Bu-FEt2-Me, 5-NH2
6146Bu-FEt2-Me, 5-NHMe
6147Bu-FEt2-Me, 5-NMe2
6148Bu-FEt2-Me, 5-NMe3OTf
6149Bu-FEt2-Me, 5-NMe3I
6150Bu-FEt2-F, 4-Me
6151Bu-FEt2-NO2, 4-Me
6152Bu-FEt2-NH2, 4-Me
6153Bu-FEt2-NHMe, 4-Me
6154Bu-FEt2-NMe2, 4-Me
6155Bu-FEt2-NMe3, 4-Me
6156Bu-FEt2-NMe3OTf, 4-Me
6157Bu-FEt2-NMe3I, 4-Me
6158Bu-FEt2-SnMe3, 4-F
6159Bu-FEt2-SnMe3, 5-F
6160Bu-FEt2-F, 4-SnMe3
6161Bu-FEt2-Br, 6-Cl, 4-F
6162Bu-FEt2-Br, 6-Cl, 4-NO2
6163Bu-FEt2-Br, 6-Cl, 4-NH2
6164Bu-FEt2-Br, 6-Cl, 4-NHMe
6165Bu-FEt2-Br, 6-Cl, 4-NMe2
6166Bu-FEt2-Br, 6-Cl, 4-NMe3OTf
6167Bu-FEt2-Br, 6-Cl, 4-NMe3I
6168Bu-FEt2-Me, 6-Cl, 4-F
6169Bu-FEt2-SnMe3, 6-Cl, 4-F
6170Bu-FEt2-Cl, 4-Me
6171Bu-FEt2-Cl, 4-Br
6172Bu-FEt2-Cl, 4-SnMe3
6173Bu-FEt2-Br, 4-Cl
6174Bu-FEt2-SnMe3, 4-Cl
6175Bu-FEt2-Me, 4-Cl
6176Bu-FEt2-Br, 4-Br
6177Bu-FEt2-Br, 4-Me
6178Bu-FEt2-Br, 4-SnMe3
6179Bu-FEt2-SnMe3, 4-Br
6180Bu-FEt2-Me, 4-Br
6181Bu-FEt2-Me, 4-SnMe3
6182Bu-FEt2-SnMe3, 4-Me
6183Bu-FEt2-Me, 4-Me
6184Bu-FEt2-Et, 4-Br
6185Bu-FEt2-Et, 4-SnMe3
6186Bu-FEt2-Et, 4-Me
6187Bu-FEt2-Me, 4-Me, 6-Me
6188Bu-FEt2-Me, 4-Br, 6-Me
6189Bu-FEt2-Me, 4-SnMe3, 6-Me
6190Bu-FEt2-Et, 6-Me
6191Bu-FEt2-Br, 4-i-Pr
6192Bu-FEt2-SnMe3, 4-i-Pr
6193Bu-FEt2-Me, 4-i-Pr
6194Bu-FEt2-Br, 4-Br, 6-Br
6195Bu-FEt2-Br, 4-Me, 6-Br
6196Bu-FEt2-Br, 4-SnMe3, 6-Br
6197Bu-FEt2-SnMe3, 4-Br, 6-Br
6198Bu-FEt2-Br, 4-Br, 6-Me
6199Bu-FEt2-Br, 4-CF3, 6-Br
6200Bu-FEt2-Br, 4-Br, 6-CF3
6201Bu-FEt2-CF3, 4-CF3
6202Bu-FEt2-Cl, 4-CF3
6203Bu-FEt2-CF3, 4-Cl
6204Bu-FEt2-Br, 4-CF3
6205Bu-FEt2-SnMe3, 4-CF3
6206Bu-FEt2-Me, 4-CF3
6207Bu-FEt2-CF3, 4-Br
6208Bu-FEt2-CF3, 4-SnMe3
6209Bu-FEt2-CF3, 4-Me
6210Bu-FEt2-Br, 4-OH
6211Bu-FEt2-Br, 4-OMe
6212Bu-FEt2-Br, 4-OMeF
6213Bu-FEt2-Br, 4-OCF3
6214Bu-FEt2-Br, 4-OEtF
6215Bu-FEt2-Br, 4-OPrF
6216Bu-FEt2-OH, 4-Br
6217Bu-FEt2-OMe, 4-Br
6218Bu-FEt2-OMeF, 4-Br
6219Bu-FEt2-OCF3, 4-Br
6220Bu-FEt2-OEtF, 4-Br
6221Bu-FEt2-OPrF, 4-Br
6222Bu-FEt2-I, 4-OH
6223Bu-FEt2-I, 4-OMe
6224Bu-FEt2-I, 4-OMeF
6225Bu-FEt2-I, 4-OCF3
6226Bu-FEt2-I, 4-OEtF
6227Bu-FEt2-I, 4-OPrF
6228Bu-FEt2-OH, 4-I
6229Bu-FEt2-OMe, 4-I
6230Bu-FEt2-OMeF, 4-I
6231Bu-FEt2-OCF3, 4-I
6232Bu-FEt2-OEtF, 4-I
6233Bu-FEt2-OPrF, 4-I
6234Bu-FEt2-SnMe3, 4-OH
6235Bu-FEt2-SnMe3, 4-OMe
6236Bu-FEt2-SnMe3, 4-OMeF
6237Bu-FEt2-SnMe3, 4-OCF3
6238Bu-FEt2-SnMe3, 4-OEtF
6239Bu-FEt2-SnMe3, 4-OPrF
6240Bu-FEt2-OH, 2-SnMe3
6241Bu-FEt2-OMe, 4-SnMe3
6242Bu-FEt2-OMeF, 4-SnMe3
6243Bu-FEt4-OCF3, 4-SnMe3
6244Bu-FEt2-OEtF, 4-SnMe3
6245Bu-FEt2-OPrF, 4-SnMe3
6246FCH2—CH═CH—CH2MeH
6247FCH2—CH═CH—CH2Me2-t-Bu
6248FCH2—CH═CH—CH2Me2-Br
6249FCH2—CH═CH—CH2Me3-Br
6250FCH2—CH═CH—CH2Me4-Br
6251FCH2—CH═CH—CH2Me2-I
6252FCH2—CH═CH—CH2Me3-I
6253FCH2—CH═CH—CH2Me4-I
6254FCH2—CH═CH—CH2Me2-SnMe3
6255FCH2—CH═CH—CH2Me3-SnMe3
6256FCH2—CH═CH—CH2Me4-SnMe3
6257FCH2—CH═CH—CH2Me2-Me
6258FCH2—CH═CH—CH2Me3-Me
6259FCH2—CH═CH—CH2Me4-Me
6260FCH2—CH═CH—CH2Me2-OH
6261FCH2—CH═CH—CH2Me3-OH
6262FCH2—CH═CH—CH2Me4-OH
6263FCH2—CH═CH—CH2Me2-OMe
6264FCH2—CH═CH—CH2Me3-OMe
6265FCH2—CH═CH—CH2Me4-OMe
6266FCH2—CH═CH—CH2Me2-OMeF
6267FCH2—CH═CH—CH2Me3-OMeF
6268FCH2—CH═CH—CH2Me4-OMeF
6269FCH2—CH═CH—CH2Me2-OCF3
6270FCH2—CH═CH—CH2Me3-OCF3
6271FCH2—CH═CH—CH2Me4-OCF3
6272FCH2—CH═CH—CH2Me2-OEtF
6273FCH2—CH═CH—CH2Me3-OEtF
6274FCH2—CH═CH—CH2Me4-OEtF
6275FCH2—CH═CH—CH2Me2-OPrF
6276FCH2—CH═CH—CH2Me3-OPrF
6277FCH2—CH═CH—CH2Me4-OPrF
6278FCH2—CH═CH—CH2Me2-SH
6279FCH2—CH═CH—CH2Me3-SH
6280FCH2—CH═CH—CH2Me4-SH
6281FCH2—CH═CH—CH2Me2-SMe
6282FCH2—CH═CH—CH2Me3-SMe
6283FCH2—CH═CH—CH2Me4-SMe
6284FCH2—CH═CH—CH2Me2-SMeF
6285FCH2—CH═CH—CH2Me3-SMeF
6286FCH2—CH═CH—CH2Me4-SMeF
6287FCH2—CH═CH—CH2Me2-SCF3
6288FCH2—CH═CH—CH2Me3-SCF3
6289FCH2—CH═CH—CH2Me4-SCF3
6290FCH2—CH═CH—CH2Me2-SEtF
6291FCH2—CH═CH—CH2Me3-SEtF
6292FCH2—CH═CH—CH2Me4-SEtF
6293FCH2—CH═CH—CH2Me2-SPrF
6294FCH2—CH═CH—CH2Me3-SPrF
6295FCH2—CH═CH—CH2Me4-SPrF
6296FCH2—CH═CH—CH2Me2-OMe, 4-OMe
6297FCH2—CH═CH—CH2Me2-Me, 5-OH
6298FCH2—CH═CH—CH2Me2-Me, 5-OMe
6299FCH2—CH═CH—CH2Me2-Me, 5-OMeF
6300FCH2—CH═CH—CH2Me2-Me, 5-OEtF
6301FCH2—CH═CH—CH2Me2-Me, 5-OPrF
6302FCH2—CH═CH—CH2Me2-Me, 4-OH
6303FCH2—CH═CH—CH2Me2-Me, 4-OMe
6304FCH2—CH═CH—CH2Me2-Me, 4-OMeF
6305FCH2—CH═CH—CH2Me2-Me, 4-OCF3
6306FCH2—CH═CH—CH2Me2-Me, 4-OEtF
6307FCH2—CH═CH—CH2Me2-Me, 4-OPrF
6308FCH2—CH═CH—CH2Me2-OH, 4-Me
6309FCH2—CH═CH—CH2Me2-OMe, 4-Me
6310FCH2—CH═CH—CH2Me2-OMeF, 4-Me
6311FCH2—CH═CH—CH2Me2-OCF3, 4-Me
6312FCH2—CH═CH—CH2Me2-OEtF, 4-Me
6313FCH2—CH═CH—CH2Me2-OPrF, 4-Me
6314FCH2—CH═CH—CH2Me2-Cl, 4-OH
6315FCH2—CH═CH—CH2Me2-Cl, 4-OMe
6316FCH2—CH═CH—CH2Me2-Cl, 4-OMeF
6317FCH2—CH═CH—CH2Me2-Cl, 4-OCF3
6318FCH2—CH═CH—CH2Me2-Cl, 4-OEtF
6319FCH2—CH═CH—CH2Me2-Cl, 4-OPrF
6320FCH2—CH═CH—CH2Me2-F, 4-F
6321FCH2—CH═CH—CH2Me2-Cl, 4-Cl
6322FCH2—CH═CH—CH2Me2-Cl, 4-F
6323FCH2—CH═CH—CH2Me2-Cl, 4-NO2
6324FCH2—CH═CH—CH2Me2-Cl, 4-NH2
6325FCH2—CH═CH—CH2Me2-Cl, 4-NHMe
6326FCH2—CH═CH—CH2Me2-Cl, 4-NMe2
6327FCH2—CH═CH—CH2Me2-Cl, 4-NMe3OTf
6328FCH2—CH═CH—CH2Me2-Cl, 4-NMe3I
6329FCH2—CH═CH—CH2Me2-Cl, 5-F
6330FCH2—CH═CH—CH2Me2-Cl, 5-NO2
6331FCH2—CH═CH—CH2Me2-Cl, 5-NH2
6332FCH2—CH═CH—CH2Me2-Cl, 5-NHMe
6333FCH2—CH═CH—CH2Me2-Cl, 5-NMe2
6334FCH2—CH═CH—CH2Me2-Cl, 5-NMe3OTf
6335FCH2—CH═CH—CH2Me2-Cl, 5-NMe3I
6336FCH2—CH═CH—CH2Me2-F, 4-Cl
6337FCH2—CH═CH—CH2Me2-NO2, 4-Cl
6338FCH2—CH═CH—CH2Me2-NH2, 4-Cl
6339FCH2—CH═CH—CH2Me2-NHMe, 4-Cl
6340FCH2—CH═CH—CH2Me2-NMe2, 4-Cl
6341FCH2—CH═CH—CH2Me2-NMe3OTf, 4-Cl
6342FCH2—CH═CH—CH2Me2-NMe3I, 4-Cl
6343FCH2—CH═CH—CH2Me2-F, 5-Cl
6344FCH2—CH═CH—CH2Me2-NO2, 5-Cl
6345FCH2—CH═CH—CH2Me2-NH2, 5-Cl
6346FCH2—CH═CH—CH2Me2-NHMe, 5-Cl
6347FCH2—CH═CH—CH2Me2-NMe2, 5-Cl
6348FCH2—CH═CH—CH2Me2-NMe3OTF, 5-Cl
6349FCH2—CH═CH—CH2Me2-NMe3I, 5-Cl
6350FCH2—CH═CH—CH2Me2-Br, 4-F
6351FCH2—CH═CH—CH2Me2-Br, 4-NO2
6352FCH2—CH═CH—CH2Me2-Br, 4-NH2
6353FCH2—CH═CH—CH2Me2-Br, 4-NHMe
6354FCH2—CH═CH—CH2Me2-Br, 4-NMe2
6355FCH2—CH═CH—CH2Me2-Br, 4-NMe3OTf
6356FCH2—CH═CH—CH2Me2-Br, 4-NMe3I
6357FCH2—CH═CH—CH2Me2-Br, 5-F
6358FCH2—CH═CH—CH2Me2-Br, 5-NO2
6359FCH2—CH═CH—CH2Me2-Br, 5-NH2
6360FCH2—CH═CH—CH2Me2-Br, 5-NHMe
6361FCH2—CH═CH—CH2Me2-Br, 5-NMe3
6362FCH2—CH═CH—CH2Me2-Br, 5-NMe3OTf
6363FCH2—CH═CH—CH2Me2-Br, 5-NMe3I
6364FCH2—CH═CH—CH2Me2-F, 4-Br
6365FCH2—CH═CH—CH2Me2-NO2, 4-Br
6366FCH2—CH═CH—CH2Me2-NH2, 4-Br
6367FCH2—CH═CH—CH2Me2-NHMe, 4-Br
6368FCH2—CH═CH—CH2Me2-NMe3, 4-Br
6369FCH2—CH═CH—CH2Me2-NMe3OTf, 4-Br
6370FCH2—CH═CH—CH2Me2-NMe3I, 4-Br
6371FCH2—CH═CH—CH2Me2-I, 4-F
6372FCH2—CH═CH—CH2Me2-I, 4-NO2
6373FCH2—CH═CH—CH2Me2-I, 4-NH2
6374FCH2—CH═CH—CH2Me2-I, 4-NHMe
6375FCH2—CH═CH—CH2Me2-I, 4-NMe2
6376FCH2—CH═CH—CH2Me2-I, 4-NMe3OTf
6377FCH2—CH═CH—CH2Me2-I, 4-NMe3I
6378FCH2—CH═CH—CH2Me2-F, 4-I
6379FCH2—CH═CH—CH2Me2-NO2, 4-I
6380FCH2—CH═CH—CH2Me2-NH2, 4-I
6381FCH2—CH═CH—CH2Me2-NHMe, 4-I
6382FCH2—CH═CH—CH2Me2-NMe2, 4-I
6383FCH2—CH═CH—CH2Me2-NMe3OTf, 4-I
6384FCH2—CH═CH—CH2Me2-NMe3I, 4-I
6385FCH2—CH═CH—CH2Me2-Me, 3-F
6386FCH2—CH═CH—CH2Me2-Me, 3-NO2
6387FCH2—CH═CH—CH2Me2-Me, 3-NH2
6388FCH2—CH═CH—CH2Me2-Me, 3-NHMe
6389FCH2—CH═CH—CH2Me2-Me, 3-NMe2
6390FCH2—CH═CH—CH2Me2-Me, 3-NMe3OTf
6391FCH2—CH═CH—CH2Me2-Me, 3-NMe3I
6392FCH2—CH═CH—CH2Me2-Me, 4-F
6393FCH2—CH═CH—CH2Me2-Me, 4-NO2
6394FCH2—CH═CH—CH2Me2-Me, 4-NH2
6395FCH2—CH═CH—CH2Me2-Me, 4-NHMe
6396FCH2—CH═CH—CH2Me2-Me, 4-NMe2
6397FCH2—CH═CH—CH2Me2-Me, 4-NMe3OTf
6398FCH2—CH═CH—CH2Me2-Me, 4-NMe3I
6399FCH2—CH═CH—CH2Me2-Me, 5-F
6400FCH2—CH═CH—CH2Me2-Me, 5-NO2
6401FCH2—CH═CH—CH2Me2-Me, 5-NH2
6402FCH2—CH═CH—CH2Me2-Me, 5-NHMe
6403FCH2—CH═CH—CH2Me2-Me, 5-NMe2
6404FCH2—CH═CH—CH2Me2-Me, 5-NMe3OTf
6405FCH2—CH═CH—CH2Me2-Me, 5-NMe3I
6406FCH2—CH═CH—CH2Me2-F, 4-Me
6407FCH2—CH═CH—CH2Me2-NO2, 4-Me
6408FCH2—CH═CH—CH2Me2-NH2, 4-Me
6409FCH2—CH═CH—CH2Me2-NHMe, 4-Me
6410FCH2—CH═CH—CH2Me2-NMe2, 4-Me
6411FCH2—CH═CH—CH2Me2-NMe3, 4-Me
6412FCH2—CH═CH—CH2Me2-NMe3OTf, 4-Me
6413FCH2—CH═CH—CH2Me2-NMe3I, 4-Me
6414FCH2—CH═CH—CH2Me2-SnMe3, 4-F
6415FCH2—CH═CH—CH2Me2-SnMe3, 5-F
6416FCH2—CH═CH—CH2Me2-F, 4-SnMe3
6417FCH2—CH═CH—CH2Me2-Br, 6-Cl, 4-F
6418FCH2—CH═CH—CH2Me2-Br, 6-Cl, 4-NO2
6419FCH2—CH═CH—CH2Me2-Br, 6-Cl, 4-NH2
6420FCH2—CH═CH—CH2Me2-Br, 6-Cl, 4-NHMe
6421FCH2—CH═CH—CH2Me2-Br, 6-Cl, 4-NMe2
6422FCH2—CH═CH—CH2Me2-Br, 6-Cl, 4-NMe3OTf
6423FCH2—CH═CH—CH2Me2-Br, 6-Cl, 4-NMe3I
6424FCH2—CH═CH—CH2Me2-Me, 6-Cl, 4-F
6425FCH2—CH═CH—CH2Me2-SnMe3, 6-Cl, 4-F
6426FCH2—CH═CH—CH2Me2-Cl, 4-Me
6427FCH2—CH═CH—CH2Me2-Cl, 4-Br
6428FCH2—CH═CH—CH2Me2-Cl, 4-SnMe3
6429FCH2—CH═CH—CH2Me2-Br, 4-Cl
6430FCH2—CH═CH—CH2Me2-SnMe3, 4-Cl
6431FCH2—CH═CH—CH2Me2-Me, 4-Cl
6432FCH2—CH═CH—CH2Me2-Br, 4-Br
6433FCH2—CH═CH—CH2Me2-Br, 4-Me
6434FCH2—CH═CH—CH2Me2-Br, 4-SnMe3
6435FCH2—CH═CH—CH2Me2-SnMe3, 4-Br
6436FCH2—CH═CH—CH2Me2-Me, 4-Br
6437FCH2—CH═CH—CH2Me2-Me, 4-SnMe3
6438FCH2—CH═CH—CH2Me2-SnMe3, 4-Me
6439FCH2—CH═CH—CH2Me2-Me, 4-Me
6440FCH2—CH═CH—CH2Me2-Et, 4-Br
6441FCH2—CH═CH—CH2Me2-Et, 4-SnMe3
6442FCH2—CH═CH—CH2Me2-Et, 4-Me
6443FCH2—CH═CH—CH2Me2-Me, 4-Me, 6-Me
6444FCH2—CH═CH—CH2Me2-Me, 4-Br, 6-Me
6445FCH2—CH═CH—CH2Me2-Me, 4-SnMe3, 6-Me
6446FCH2—CH═CH—CH2Me2-Et, 6-Me
6447FCH2—CH═CH—CH2Me2-Br, 4-i-Pr
6448FCH2—CH═CH—CH2Me2-SnMe3, 4-i-Pr
6449FCH2—CH═CH—CH2Me2-Me, 4-i-Pr
6450FCH2—CH═CH—CH2Me2-Br, 4-Br, 6-Br
6451FCH2—CH═CH—CH2Me2-Br, 4-Me, 6-Br
6452FCH2—CH═CH—CH2Me2-Br, 4-SnMe3, 6-Br
6453FCH2—CH═CH—CH2Me2-SnMe3, 4-Br, 6-Br
6454FCH2—CH═CH—CH2Me2-Br, 4-Br, 6-Me
6455FCH2—CH═CH—CH2Me2-Br, 4-CF3, 6-Br
6456FCH2—CH═CH—CH2Me2-Br, 4-Br, 6-CF3
6457FCH2—CH═CH—CH2Me2-CF3, 4-CF3
6458FCH2—CH═CH—CH2Me2-Cl, 4-CF3
6459FCH2—CH═CH—CH2Me2-CF3, 4-Cl
6460FCH2—CH═CH—CH2Me2-Br, 4-CF3
6461FCH2—CH═CH—CH2Me2-SnMe3, 4-CF3
6462FCH2—CH═CH—CH2Me2-Me, 4-CF3
6463FCH2—CH═CH—CH2Me2-CF3, 4-Br
6464FCH2—CH═CH—CH2Me2-CF3, 4-SnMe3
6465FCH2—CH═CH—CH2Me2-CF3, 4-Me
6466FCH2—CH═CH—CH2Me2-Br, 4-OH
6467FCH2—CH═CH—CH2Me2-Br, 4-OMe
6468FCH2—CH═CH—CH2Me2-Br, 4-OMeF
6469FCH2—CH═CH—CH2Me2-Br, 4-OCF3
6470FCH2—CH═CH—CH2Me2-Br, 4-OEtF
6471FCH2—CH═CH—CH2Me2-Br, 4-OPrF
6472FCH2—CH═CH—CH2Me2-OH, 4-Br
6473FCH2—CH═CH—CH2Me2-OMe, 4-Br
6474FCH2—CH═CH—CH2Me2-OMeF, 4-Br
6475FCH2—CH═CH—CH2Me2-OCF3, 4-Br
6476FCH2—CH═CH—CH2Me2-OEtF, 4-Br
6477FCH2—CH═CH—CH2Me2-OPrF, 4-Br
6478FCH2—CH═CH—CH2Me2-I, 4-OH
6479FCH2—CH═CH—CH2Me2-I, 4-OMe
6480FCH2—CH═CH—CH2Me2-I, 4-OMeF
6481FCH2—CH═CH—CH2Me2-I, 4-OCF3
6482FCH2—CH═CH—CH2Me2-I, 4-OEtF
6483FCH2—CH═CH—CH2Me2-I, 4-OPrF
6484FCH2—CH═CH—CH2Me2-OH, 4-I
6485FCH2—CH═CH—CH2Me2-OMe, 4-I
6486FCH2—CH═CH—CH2Me2-OMeF, 4-I
6487FCH2—CH═CH—CH2Me2-OCF3, 4-I
6488FCH2—CH═CH—CH2Me2-OEtF, 4-I
6489FCH2—CH═CH—CH2Me2-OPrF, 4-I
6490FCH2—CH═CH—CH2Me2-SnMe3, 4-OH
6491FCH2—CH═CH—CH2Me2-SnMe3, 4-OMe
6492FCH2—CH═CH—CH2Me2-SnMe3, 4-OMeF
6493FCH2—CH═CH—CH2Me2-SnMe3, 4-OCF3
6494FCH2—CH═CH—CH2Me2-SnMe3, 4-OEtF
6495FCH2—CH═CH—CH2Me2-SnMe3, 4-OPrF
6496FCH2—CH═CH—CH2Me2-OH, 2-SnMe3
6497FCH2—CH═CH—CH2Me2-OMe, 4-SnMe3
6498FCH2—CH═CH—CH2Me2-OMeF, 4-SnMe3
6499FCH2—CH═CH—CH2Me4-OCF3, 4-SnMe3
6500FCH2—CH═CH—CH2Me2-OEtF, 4-SnMe3
6501FCH2—CH═CH—CH2Me2-OPrF, 4-SnMe3
6502FCH2—CH═CH—CH2EtH
6503FCH2—CH═CH—CH2Et2-t-Bu
6504FCH2—CH═CH—CH2Et2-Br
6505FCH2—CH═CH—CH2Et3-Br
6506FCH2—CH═CH—CH2Et4-Br
6507FCH2—CH═CH—CH2Et2-I
6508FCH2—CH═CH—CH2Et3-I
6509FCH2—CH═CH—CH2Et4-I
6510FCH2—CH═CH—CH2Et2-SnMe3
6511FCH2—CH═CH—CH2Et3-SnMe3
6512FCH2—CH═CH—CH2Et4-SnMe3
6513FCH2—CH═CH—CH2Et2-Me
6514FCH2—CH═CH—CH2Et3-Me
6515FCH2—CH═CH—CH2Et4-Me
6516FCH2—CH═CH—CH2Et2-OH
6517FCH2—CH═CH—CH2Et3-OH
6518FCH2—CH═CH—CH2Et4-OH
6519FCH2—CH═CH—CH2Et2-OMe
6520FCH2—CH═CH—CH2Et3-OMe
6521FCH2—CH═CH—CH2Et4-OMe
6522FCH2—CH═CH—CH2Et2-OMeF
6523FCH2—CH═CH—CH2Et3-OMeF
6524FCH2—CH═CH—CH2Et4-OMeF
6525FCH2—CH═CH—CH2Et2-OCF3
6526FCH2—CH═CH—CH2Et3-OCF3
6527FCH2—CH═CH—CH2Et4-OCF3
6528FCH2—CH═CH—CH2Et2-OEtF
6529FCH2—CH═CH—CH2Et3-OEtF
6530FCH2—CH═CH—CH2Et4-OEtF
6531FCH2—CH═CH—CH2Et2-OPrF
6532FCH2—CH═CH—CH2Et3-OPrF
6533FCH2—CH═CH—CH2Et4-OPrF
6534FCH2—CH═CH—CH2Et2-SH
6535FCH2—CH═CH—CH2Et3-SH
6536FCH2—CH═CH—CH2Et4-SH
6537FCH2—CH═CH—CH2Et2-SMe
6538FCH2—CH═CH—CH2Et3-SMe
6539FCH2—CH═CH—CH2Et4-SMe
6540FCH2—CH═CH—CH2Et2-SMeF
6541FCH2—CH═CH—CH2Et3-SMeF
6542FCH2—CH═CH—CH2Et4-SMeF
6543FCH2—CH═CH—CH2Et2-SCF3
6544FCH2—CH═CH—CH2Et3-SCF3
6545FCH2—CH═CH—CH2Et4-SCF3
6546FCH2—CH═CH—CH2Et2-SEtF
6547FCH2—CH═CH—CH2Et3-SEtF
6548FCH2—CH═CH—CH2Et4-SEtF
6549FCH2—CH═CH—CH2Et2-SPrF
6550FCH2—CH═CH—CH2Et3-SPrF
6551FCH2—CH═CH—CH2Et4-SPrF
6552FCH2—CH═CH—CH2Et2-OMe, 4-OMe
6553FCH2—CH═CH—CH2Et2-Me, 5-OH
6554FCH2—CH═CH—CH2Et2-Me, 5-OMe
6555FCH2—CH═CH—CH2Et2-Me, 5-OMeF
6556FCH2—CH═CH—CH2Et2-Me, 5-OEtF
6557FCH2—CH═CH—CH2Et2-Me, 5-OPrF
6558FCH2—CH═CH—CH2Et2-Me, 4-OH
6559FCH2—CH═CH—CH2Et2-Me, 4-OMe
6560FCH2—CH═CH—CH2Et2-Me, 4-OMeF
6561FCH2—CH═CH—CH2Et2-Me, 4-OCF3
6562FCH2—CH═CH—CH2Et2-Me, 4-OEtF
6563FCH2—CH═CH—CH2Et2-Me, 4-OPrF
6564FCH2—CH═CH—CH2Et2-OH, 4-Me
6565FCH2—CH═CH—CH2Et2-OMe, 4-Me
6566FCH2—CH═CH—CH2Et2-OMeF, 4-Me
6567FCH2—CH═CH—CH2Et2-OCF3, 4-Me
6568FCH2—CH═CH—CH2Et2-OEtF, 4-Me
6569FCH2—CH═CH—CH2Et2-OPrF, 4-Me
6570FCH2—CH═CH—CH2Et2-Cl, 4-OH
6571FCH2—CH═CH—CH2Et2-Cl, 4-OMe
6572FCH2—CH═CH—CH2Et2-Cl, 4-OMeF
6573FCH2—CH═CH—CH2Et2-Cl, 4-OCF3
6574FCH2—CH═CH—CH2Et2-Cl, 4-OEtF
6575FCH2—CH═CH—CH2Et2-Cl, 4-OPrF
6576FCH2—CH═CH—CH2Et2-F, 4-F
6577FCH2—CH═CH—CH2Et2-Cl, 4-Cl
6578FCH2—CH═CH—CH2Et2-Cl, 4-F
6579FCH2—CH═CH—CH2Et2-Cl, 4-NO2
6580FCH2—CH═CH—CH2Et2-Cl, 4-NH2
6581FCH2—CH═CH—CH2Et2-Cl, 4-NHMe
6582FCH2—CH═CH—CH2Et2-Cl, 4-NMe2
6583FCH2—CH═CH—CH2Et2-Cl, 4-NMe3OTf
6584FCH2—CH═CH—CH2Et2-Cl, 4-NMe3I
6585FCH2—CH═CH—CH2Et2-Cl, 5-F
6586FCH2—CH═CH—CH2Et2-Cl, 5-NO2
6587FCH2—CH═CH—CH2Et2-Cl, 5-NH2
6588FCH2—CH═CH—CH2Et2-Cl, 5-NHMe
6589FCH2—CH═CH—CH2Et2-Cl, 5-NMe2
6590FCH2—CH═CH—CH2Et2-Cl, 5-NMe3OTf
6591FCH2—CH═CH—CH2Et2-Cl, 5-NMe3I
6592FCH2—CH═CH—CH2Et2-F, 4-Cl
6593FCH2—CH═CH—CH2Et2-NO2, 4-Cl
6594FCH2—CH═CH—CH2Et2-NH2, 4-Cl
6595FCH2—CH═CH—CH2Et2-NHMe, 4-Cl
6596FCH2—CH═CH—CH2Et2-NMe2, 4-Cl
6597FCH2—CH═CH—CH2Et2-NMe3OTf, 4-Cl
6598FCH2—CH═CH—CH2Et2-NMe3I, 4-Cl
6599FCH2—CH═CH—CH2Et2-F, 5-Cl
6600FCH2—CH═CH—CH2Et2-NO2, 5-Cl
6601FCH2—CH═CH—CH2Et2-NH2, 5-Cl
6602FCH2—CH═CH—CH2Et2-NHMe, 5-Cl
6603FCH2—CH═CH—CH2Et2-NMe2, 5-Cl
6604FCH2—CH═CH—CH2Et2-NMe3OTF, 5-Cl
6605FCH2—CH═CH—CH2Et2-NMe3I, 5-Cl
6606FCH2—CH═CH—CH2Et2-Br, 4-F
6607FCH2—CH═CH—CH2Et2-Br, 4-NO2
6608FCH2—CH═CH—CH2Et2-Br, 4-NH2
6609FCH2—CH═CH—CH2Et2-Br, 4-NHMe
6610FCH2—CH═CH—CH2Et2-Br, 4-NMe2
6611FCH2—CH═CH—CH2Et2-Br, 4-NMe3OTf
6612FCH2—CH═CH—CH2Et2-Br, 4-NMe3I
6613FCH2—CH═CH—CH2Et2-Br, 5-F
6614FCH2—CH═CH—CH2Et2-Br, 5-NO2
6615FCH2—CH═CH—CH2Et2-Br, 5-NH2
6616FCH2—CH═CH—CH2Et2-Br, 5-NHMe
6617FCH2—CH═CH—CH2Et2-Br, 5-NMe3
6618FCH2—CH═CH—CH2Et2-Br, 5-NMe3OTf
6619FCH2—CH═CH—CH2Et2-Br, 5-NMe3I
6620FCH2—CH═CH—CH2Et2-F, 4-Br
6621FCH2—CH═CH—CH2Et2-NO2, 4-Br
6622FCH2—CH═CH—CH2Et2-NH2, 4-Br
6623FCH2—CH═CH—CH2Et2-NHMe, 4-Br
6624FCH2—CH═CH—CH2Et2-NMe3, 4-Br
6625FCH2—CH═CH—CH2Et2-NMe3OTf, 4-Br
6626FCH2—CH═CH—CH2Et2-NMe3I, 4-Br
6627FCH2—CH═CH—CH2Et2-I, 4-F
6628FCH2—CH═CH—CH2Et2-I, 4-NO2
6629FCH2—CH═CH—CH2Et2-I, 4-NH2
6630FCH2—CH═CH—CH2Et2-I, 4-NHMe
6631FCH2—CH═CH—CH2Et2-I, 4-NMe2
6632FCH2—CH═CH—CH2Et2-I, 4-NMe3OTf
6633FCH2—CH═CH—CH2Et2-I, 4-NMe3I
6634FCH2—CH═CH—CH2Et2-F, 4-I
6635FCH2—CH═CH—CH2Et2-NO2, 4-I
6636FCH2—CH═CH—CH2Et2-NH2, 4-I
6637FCH2—CH═CH—CH2Et2-NHMe, 4-I
6638FCH2—CH═CH—CH2Et2-NMe2, 4-I
6639FCH2—CH═CH—CH2Et2-NMe3OTf, 4-I
6640FCH2—CH═CH—CH2Et2-NMe3I, 4-I
6641FCH2—CH═CH—CH2Et2-Me, 3-F
6642FCH2—CH═CH—CH2Et2-Me, 3-NO2
6643FCH2—CH═CH—CH2Et2-Me, 3-NH2
6644FCH2—CH═CH—CH2Et2-Me, 3-NHMe
6645FCH2—CH═CH—CH2Et2-Me, 3-NMe2
6646FCH2—CH═CH—CH2Et2-Me, 3-NMe3OTf
6647FCH2—CH═CH—CH2Et2-Me, 3-NMe3I
6648FCH2—CH═CH—CH2Et2-Me, 4-F
6649FCH2—CH═CH—CH2Et2-Me, 4-NO2
6650FCH2—CH═CH—CH2Et2-Me, 4-NH2
6651FCH2—CH═CH—CH2Et2-Me, 4-NHMe
6652FCH2—CH═CH—CH2Et2-Me, 4-NMe2
6653FCH2—CH═CH—CH2Et2-Me, 4-NMe3OTf
6654FCH2—CH═CH—CH2Et2-Me, 4-NMe3I
6655FCH2—CH═CH—CH2Et2-Me, 5-F
6656FCH2—CH═CH—CH2Et2-Me, 5-NO2
6657FCH2—CH═CH—CH2Et2-Me, 5-NH2
6658FCH2—CH═CH—CH2Et2-Me, 5-NHMe
6659FCH2—CH═CH—CH2Et2-Me, 5-NMe2
6660FCH2—CH═CH—CH2Et2-Me, 5-NMe3OTf
6661FCH2—CH═CH—CH2Et2-Me, 5-NMe3I
6662FCH2—CH═CH—CH2Et2-F, 4-Me
6663FCH2—CH═CH—CH2Et2-NO2, 4-Me
6664FCH2—CH═CH—CH2Et2-NH2, 4-Me
6665FCH2—CH═CH—CH2Et2-NHMe, 4-Me
6666FCH2—CH═CH—CH2Et2-NMe2, 4-Me
6667FCH2—CH═CH—CH2Et2-NMe3, 4-Me
6668FCH2—CH═CH—CH2Et2-NMe3OTf, 4-Me
6669FCH2—CH═CH—CH2Et2-NMe3I, 4-Me
6670FCH2—CH═CH—CH2Et2-SnMe3, 4-F
6671FCH2—CH═CH—CH2Et2-SnMe3, 5-F
6672FCH2—CH═CH—CH2Et2-F, 4-SnMe3
6673FCH2—CH═CH—CH2Et2-Br, 6-Cl, 4-F
6674FCH2—CH═CH—CH2Et2-Br, 6-Cl, 4-NO2
6675FCH2—CH═CH—CH2Et2-Br, 6-Cl, 4-NH2
6676FCH2—CH═CH—CH2Et2-Br, 6-Cl, 4-NHMe
6677FCH2—CH═CH—CH2Et2-Br, 6-Cl, 4-NMe2
6678FCH2—CH═CH—CH2Et2-Br, 6-Cl, 4-NMe3OTf
6679FCH2—CH═CH—CH2Et2-Br, 6-Cl, 4-NMe3I
6680FCH2—CH═CH—CH2Et2-Me, 6-Cl, 4-F
6681FCH2—CH═CH—CH2Et2-SnMe3, 6-Cl, 4-F
6682FCH2—CH═CH—CH2Et2-Cl, 4-Me
6683FCH2—CH═CH—CH2Et2-Cl, 4-Br
6684FCH2—CH═CH—CH2Et2-Cl, 4-SnMe3
6685FCH2—CH═CH—CH2Et2-Br, 4-Cl
6686FCH2—CH═CH—CH2Et2-SnMe3, 4-Cl
6687FCH2—CH═CH—CH2Et2-Me, 4-Cl
6688FCH2—CH═CH—CH2Et2-Br, 4-Br
6689FCH2—CH═CH—CH2Et2-Br, 4-Me
6690FCH2—CH═CH—CH2Et2-Br, 4-SnMe3
6691FCH2—CH═CH—CH2Et2-SnMe3, 4-Br
6692FCH2—CH═CH—CH2Et2-Me, 4-Br
6693FCH2—CH═CH—CH2Et2-Me, 4-SnMe3
6694FCH2—CH═CH—CH2Et2-SnMe3, 4-Me
6695FCH2—CH═CH—CH2Et2-Me, 4-Me
6696FCH2—CH═CH—CH2Et2-Et, 4-Br
6697FCH2—CH═CH—CH2Et2-Et, 4-SnMe3
6698FCH2—CH═CH—CH2Et2-Et, 4-Me
6699FCH2—CH═CH—CH2Et2-Me, 4-Me, 6-Me
6700FCH2—CH═CH—CH2Et2-Me, 4-Br, 6-Me
6701FCH2—CH═CH—CH2Et2-Me, 4-SnMe3, 6-Me
6702FCH2—CH═CH—CH2Et2-Et, 6-Me
6703FCH2—CH═CH—CH2Et2-Br, 4-i-Pr
6704FCH2—CH═CH—CH2Et2-SnMe3, 4-i-Pr
6705FCH2—CH═CH—CH2Et2-Me, 4-i-Pr
6706FCH2—CH═CH—CH2Et2-Br, 4-Br, 6-Br
6707FCH2—CH═CH—CH2Et2-Br, 4-Me, 6-Br
6708FCH2—CH═CH—CH2Et2-Br, 4-SnMe3, 6-Br
6709FCH2—CH═CH—CH2Et2-SnMe3, 4-Br, 6-Br
6710FCH2—CH═CH—CH2Et2-Br, 4-Br, 6-Me
6711FCH2—CH═CH—CH2Et2-Br, 4-CF3, 6-Br
6712FCH2—CH═CH—CH2Et2-Br, 4-Br, 6-CF3
6713FCH2—CH═CH—CH2Et2-CF3, 4-CF3
6714FCH2—CH═CH—CH2Et2-Cl, 4-CF3
6715FCH2—CH═CH—CH2Et2-CF3, 4-Cl
6716FCH2—CH═CH—CH2Et2-Br, 4-CF3
6717FCH2—CH═CH—CH2Et2-SnMe3, 4-CF3
6718FCH2—CH═CH—CH2Et2-Me, 4-CF3
6719FCH2—CH═CH—CH2Et2-CF3, 4-Br
6720FCH2—CH═CH—CH2Et2-CF3, 4-SnMe3
6721FCH2—CH═CH—CH2Et2-CF3, 4-Me
6722FCH2—CH═CH—CH2Et2-Br, 4-OH
6723FCH2—CH═CH—CH2Et2-Br, 4-OMe
6724FCH2—CH═CH—CH2Et2-Br, 4-OMeF
6725FCH2—CH═CH—CH2Et2-Br, 4-OCF3
6726FCH2—CH═CH—CH2Et2-Br, 4-OEtF
6727FCH2—CH═CH—CH2Et2-Br, 4-OPrF
6728FCH2—CH═CH—CH2Et2-OH, 4-Br
6729FCH2—CH═CH—CH2Et2-OMe, 4-Br
6730FCH2—CH═CH—CH2Et2-OMeF, 4-Br
6731FCH2—CH═CH—CH2Et2-OCF3, 4-Br
6732FCH2—CH═CH—CH2Et2-OEtF, 4-Br
6733FCH2—CH═CH—CH2Et2-OPrF, 4-Br
6734FCH2—CH═CH—CH2Et2-I, 4-OH
6735FCH2—CH═CH—CH2Et2-I, 4-OMe
6736FCH2—CH═CH—CH2Et2-I, 4-OMeF
6737FCH2—CH═CH—CH2Et2-I, 4-OCF3
6738FCH2—CH═CH—CH2Et2-I, 4-OEtF
6739FCH2—CH═CH—CH2Et2-I, 4-OPrF
6740FCH2—CH═CH—CH2Et2-OH, 4-I
6741FCH2—CH═CH—CH2Et2-OMe, 4-I
6742FCH2—CH═CH—CH2Et2-OMeF, 4-I
6743FCH2—CH═CH—CH2Et2-OCF3, 4-I
6744FCH2—CH═CH—CH2Et2-OEtF, 4-I
6745FCH2—CH═CH—CH2Et2-OPrF, 4-I
6746FCH2—CH═CH—CH2Et2-SnMe3, 4-OH
6747FCH2—CH═CH—CH2Et2-SnMe3, 4-OMe
6748FCH2—CH═CH—CH2Et2-SnMe3, 4-OMeF
6749FCH2—CH═CH—CH2Et2-SnMe3, 4-OCF3
6750FCH2—CH═CH—CH2Et2-SnMe3, 4-OEtF
6751FCH2—CH═CH—CH2Et2-SnMe3, 4-OPrF
6752FCH2—CH═CH—CH2Et2-OH, 2-SnMe3
6753FCH2—CH═CH—CH2Et2-OMe, 4-SnMe3
6754FCH2—CH═CH—CH2Et2-OMeF, 4-SnMe3
6755FCH2—CH═CH—CH2Et4-OCF3, 4-SnMe3
6756FCH2—CH═CH—CH2Et2-OEtF, 4-SnMe3
6757FCH2—CH═CH—CH2Et2-OPrF, 4-SnMe3
6758FCH2—CH═CH—CH2Et-FH
6759FCH2—CH═CH—CH2Et-F2-t-Bu
6760FCH2—CH═CH—CH2Et-F2-Br
6761FCH2—CH═CH—CH2Et-F3-Br
6762FCH2—CH═CH—CH2Et-F4-Br
6763FCH2—CH═CH—CH2Et-F2-I
6764FCH2—CH═CH—CH2Et-F3-I
6765FCH2—CH═CH—CH2Et-F4-I
6766FCH2—CH═CH—CH2Et-F2-SnMe3
6767FCH2—CH═CH—CH2Et-F3-SnMe3
6768FCH2—CH═CH—CH2Et-F4-SnMe3
6769FCH2—CH═CH—CH2Et-F2-Me
6770FCH2—CH═CH—CH2Et-F3-Me
6771FCH2—CH═CH—CH2Et-F4-Me
6772FCH2—CH═CH—CH2Et-F2-OH
6773FCH2—CH═CH—CH2Et-F3-OH
6774FCH2—CH═CH—CH2Et-F4-OH
6775FCH2—CH═CH—CH2Et-F2-OMe
6776FCH2—CH═CH—CH2Et-F3-OMe
6777FCH2—CH═CH—CH2Et-F4-OMe
6778FCH2—CH═CH—CH2Et-F2-OMeF
6779FCH2—CH═CH—CH2Et-F3-OMeF
6780FCH2—CH═CH—CH2Et-F4-OMeF
6781FCH2—CH═CH—CH2Et-F2-OCF3
6782FCH2—CH═CH—CH2Et-F3-OCF3
6783FCH2—CH═CH—CH2Et-F4-OCF3
6784FCH2—CH═CH—CH2Et-F2-OEtF
6785FCH2—CH═CH—CH2Et-F3-OEtF
6786FCH2—CH═CH—CH2Et-F4-OEtF
6787FCH2—CH═CH—CH2Et-F2-OPrF
6788FCH2—CH═CH—CH2Et-F3-OPrF
6789FCH2—CH═CH—CH2Et-F4-OPrF
6790FCH2—CH═CH—CH2Et-F2-SH
6791FCH2—CH═CH—CH2Et-F3-SH
6792FCH2—CH═CH—CH2Et-F4-SH
6793FCH2—CH═CH—CH2Et-F2-SMe
6794FCH2—CH═CH—CH2Et-F3-SMe
6795FCH2—CH═CH—CH2Et-F4-SMe
6796FCH2—CH═CH—CH2Et-F2-SMeF
6797FCH2—CH═CH—CH2Et-F3-SMeF
6798FCH2—CH═CH—CH2Et-F4-SMeF
6799FCH2—CH═CH—CH2Et-F2-SCF3
6800FCH2—CH═CH—CH2Et-F3-SCF3
6801FCH2—CH═CH—CH2Et-F4-SCF3
6802FCH2—CH═CH—CH2Et-F2-SEtF
6803FCH2—CH═CH—CH2Et-F3-SEtF
6804FCH2—CH═CH—CH2Et-F4-SEtF
6805FCH2—CH═CH—CH2Et-F2-SPrF
6806FCH2—CH═CH—CH2Et-F3-SPrF
6807FCH2—CH═CH—CH2Et-F4-SPrF
6808FCH2—CH═CH—CH2Et-F2-OMe, 4-OMe
6809FCH2—CH═CH—CH2Et-F2-Me, 5-OH
6810FCH2—CH═CH—CH2Et-F2-Me, 5-OMe
6811FCH2—CH═CH—CH2Et-F2-Me, 5-OMeF
6812FCH2—CH═CH—CH2Et-F2-Me, 5-OEtF
6813FCH2—CH═CH—CH2Et-F2-Me, 5-OPrF
6814FCH2—CH═CH—CH2Et-F2-Me, 4-OH
6815FCH2—CH═CH—CH2Et-F2-Me, 4-OMe
6816FCH2—CH═CH—CH2Et-F2-Me, 4-OMeF
6817FCH2—CH═CH—CH2Et-F2-Me, 4-OCF3
6818FCH2—CH═CH—CH2Et-F2-Me, 4-OEtF
6819FCH2—CH═CH—CH2Et-F2-Me, 4-OPrF
6820FCH2—CH═CH—CH2Et-F2-OH, 4-Me
6821FCH2—CH═CH—CH2Et-F2-OMe, 4-Me
6822FCH2—CH═CH—CH2Et-F2-OMeF, 4-Me
6823FCH2—CH═CH—CH2Et-F2-OCF3, 4-Me
6824FCH2—CH═CH—CH2Et-F2-OEtF, 4-Me
6825FCH2—CH═CH—CH2Et-F2-OPrF, 4-Me
6826FCH2—CH═CH—CH2Et-F2-Cl, 4-OH
6827FCH2—CH═CH—CH2Et-F2-Cl, 4-OMe
6828FCH2—CH═CH—CH2Et-F2-Cl, 4-OMeF
6829FCH2—CH═CH—CH2Et-F2-Cl, 4-OCF3
6830FCH2—CH═CH—CH2Et-F2-Cl, 4-OEtF
6831FCH2—CH═CH—CH2Et-F2-Cl, 4-OPrF
6832FCH2—CH═CH—CH2Et-F2-F, 4-F
6833FCH2—CH═CH—CH2Et-F2-Cl, 4-Cl
6834FCH2—CH═CH—CH2Et-F2-Cl, 4-F
6835FCH2—CH═CH—CH2Et-F2-Cl, 4-NO2
6836FCH2—CH═CH—CH2Et-F2-Cl, 4-NH2
6837FCH2—CH═CH—CH2Et-F2-Cl, 4-NHMe
6838FCH2—CH═CH—CH2Et-F2-Cl, 4-NMe2
6839FCH2—CH═CH—CH2Et-F2-Cl, 4-NMe3OTf
6840FCH2—CH═CH—CH2Et-F2-Cl, 4-NMe3I
6841FCH2—CH═CH—CH2Et-F2-Cl, 5-F
6842FCH2—CH═CH—CH2Et-F2-Cl, 5-NO2
6843FCH2—CH═CH—CH2Et-F2-Cl, 5-NH2
6844FCH2—CH═CH—CH2Et-F2-Cl, 5-NHMe
6845FCH2—CH═CH—CH2Et-F2-Cl, 5-NMe2
6846FCH2—CH═CH—CH2Et-F2-Cl, 5-NMe3OTf
6847FCH2—CH═CH—CH2Et-F2-Cl, 5-NMe3I
6848FCH2—CH═CH—CH2Et-F2-F, 4-Cl
6849FCH2—CH═CH—CH2Et-F2-NO2, 4-Cl
6850FCH2—CH═CH—CH2Et-F2-NH2, 4-Cl
6851FCH2—CH═CH—CH2Et-F2-NHMe, 4-Cl
6852FCH2—CH═CH—CH2Et-F2-NMe2, 4-Cl
6853FCH2—CH═CH—CH2Et-F2-NMe3OTf, 4-Cl
6854FCH2—CH═CH—CH2Et-F2-NMe3I, 4-Cl
6855FCH2—CH═CH—CH2Et-F2-F, 5-Cl
6856FCH2—CH═CH—CH2Et-F2-NO2, 5-Cl
6857FCH2—CH═CH—CH2Et-F2-NH2, 5-Cl
6858FCH2—CH═CH—CH2Et-F2-NHMe, 5-Cl
6859FCH2—CH═CH—CH2Et-F2-NMe2, 5-Cl
6860FCH2—CH═CH—CH2Et-F2-NMe3OTF, 5-Cl
6861FCH2—CH═CH—CH2Et-F2-NMe3I, 5-Cl
6862FCH2—CH═CH—CH2Et-F2-Br, 4-F
6863FCH2—CH═CH—CH2Et-F2-Br, 4-NO2
6864FCH2—CH═CH—CH2Et-F2-Br, 4-NH2
6865FCH2—CH═CH—CH2Et-F2-Br, 4-NHMe
6866FCH2—CH═CH—CH2Et-F2-Br, 4-NMe2
6867FCH2—CH═CH—CH2Et-F2-Br, 4-NMe3OTf
6868FCH2—CH═CH—CH2Et-F2-Br, 4-NMe3I
6869FCH2—CH═CH—CH2Et-F2-Br, 5-F
6870FCH2—CH═CH—CH2Et-F2-Br, 5-NO2
6871FCH2—CH═CH—CH2Et-F2-Br, 5-NH2
6872FCH2—CH═CH—CH2Et-F2-Br, 5-NHMe
6873FCH2—CH═CH—CH2Et-F2-Br, 5-NMe3
6874FCH2—CH═CH—CH2Et-F2-Br, 5-NMe3OTf
6875FCH2—CH═CH—CH2Et-F2-Br, 5-NMe3I
6876FCH2—CH═CH—CH2Et-F2-F, 4-Br
6877FCH2—CH═CH—CH2Et-F2-NO2, 4-Br
6878FCH2—CH═CH—CH2Et-F2-NH2, 4-Br
6879FCH2—CH═CH—CH2Et-F2-NHMe, 4-Br
6880FCH2—CH═CH—CH2Et-F2-NMe3, 4-Br
6881FCH2—CH═CH—CH2Et-F2-NMe3OTf, 4-Br
6882FCH2—CH═CH—CH2Et-F2-NMe3I, 4-Br
6883FCH2—CH═CH—CH2Et-F2-I, 4-F
6884FCH2—CH═CH—CH2Et-F2-I, 4-NO2
6885FCH2—CH═CH—CH2Et-F2-I, 4-NH2
6886FCH2—CH═CH—CH2Et-F2-I, 4-NHMe
6887FCH2—CH═CH—CH2Et-F2-I, 4-NMe2
6888FCH2—CH═CH—CH2Et-F2-I, 4-NMe3OTf
6889FCH2—CH═CH—CH2Et-F2-I, 4-NMe3I
6890FCH2—CH═CH—CH2Et-F2-F, 4-I
6891FCH2—CH═CH—CH2Et-F2-NO2, 4-I
6892FCH2—CH═CH—CH2Et-F2-NH2, 4-I
6893FCH2—CH═CH—CH2Et-F2-NHMe, 4-I
6894FCH2—CH═CH—CH2Et-F2-NMe2, 4-I
6895FCH2—CH═CH—CH2Et-F2-NMe3OTf, 4-I
6896FCH2—CH═CH—CH2Et-F2-NMe3I, 4-I
6897FCH2—CH═CH—CH2Et-F2-Me, 3-F
6898FCH2—CH═CH—CH2Et-F2-Me, 3-NO2
6899FCH2—CH═CH—CH2Et-F2-Me, 3-NH2
6900FCH2—CH═CH—CH2Et-F2-Me, 3-NHMe
6901FCH2—CH═CH—CH2Et-F2-Me, 3-NMe2
6902FCH2—CH═CH—CH2Et-F2-Me, 3-NMe3OTf
6903FCH2—CH═CH—CH2Et-F2-Me, 3-NMe3I
6904FCH2—CH═CH—CH2Et-F2-Me, 4-F
6905FCH2—CH═CH—CH2Et-F2-Me, 4-NO2
6906FCH2—CH═CH—CH2Et-F2-Me, 4-NH2
6907FCH2—CH═CH—CH2Et-F2-Me, 4-NHMe
6908FCH2—CH═CH—CH2Et-F2-Me, 4-NMe2
6909FCH2—CH═CH—CH2Et-F2-Me, 4-NMe3OTf
6910FCH2—CH═CH—CH2Et-F2-Me, 4-NMe3I
6911FCH2—CH═CH—CH2Et-F2-Me, 5-F
6912FCH2—CH═CH—CH2Et-F2-Me, 5-NO2
6913FCH2—CH═CH—CH2Et-F2-Me, 5-NH2
6914FCH2—CH═CH—CH2Et-F2-Me, 5-NHMe
6915FCH2—CH═CH—CH2Et-F2-Me, 5-NMe2
6916FCH2—CH═CH—CH2Et-F2-Me, 5-NMe3OTf
6917FCH2—CH═CH—CH2Et-F2-Me, 5-NMe3I
6918FCH2—CH═CH—CH2Et-F2-F, 4-Me
6919FCH2—CH═CH—CH2Et-F2-NO2, 4-Me
6920FCH2—CH═CH—CH2Et-F2-NH2, 4-Me
6921FCH2—CH═CH—CH2Et-F2-NHMe, 4-Me
6922FCH2—CH═CH—CH2Et-F2-NMe2, 4-Me
6923FCH2—CH═CH—CH2Et-F2-NMe3, 4-Me
6924FCH2—CH═CH—CH2Et-F2-NMe3OTf, 4-Me
6925FCH2—CH═CH—CH2Et-F2-NMe3I, 4-Me
6926FCH2—CH═CH—CH2Et-F2-SnMe3, 4-F
6927FCH2—CH═CH—CH2Et-F2-SnMe3, 5-F
6928FCH2—CH═CH—CH2Et-F2-F, 4-SnMe3
6929FCH2—CH═CH—CH2Et-F2-Br, 6-Cl, 4-F
6930FCH2—CH═CH—CH2Et-F2-Br, 6-Cl, 4-NO2
6931FCH2—CH═CH—CH2Et-F2-Br, 6-Cl, 4-NH2
6932FCH2—CH═CH—CH2Et-F2-Br, 6-Cl, 4-NHMe
6933FCH2—CH═CH—CH2Et-F2-Br, 6-Cl, 4-NMe2
6934FCH2—CH═CH—CH2Et-F2-Br, 6-Cl, 4-NMe3OTf
6935FCH2—CH═CH—CH2Et-F2-Br, 6-Cl, 4-NMe3I
6936FCH2—CH═CH—CH2Et-F2-Me, 6-Cl, 4-F
6937FCH2—CH═CH—CH2Et-F2-SnMe3, 6-Cl, 4-F
6938FCH2—CH═CH—CH2Et-F2-Cl, 4-Me
6939FCH2—CH═CH—CH2Et-F2-Cl, 4-Br
6940FCH2—CH═CH—CH2Et-F2-Cl, 4-SnMe3
6941FCH2—CH═CH—CH2Et-F2-Br, 4-Cl
6942FCH2—CH═CH—CH2Et-F2-SnMe3, 4-Cl
6943FCH2—CH═CH—CH2Et-F2-Me, 4-Cl
6944FCH2—CH═CH—CH2Et-F2-Br, 4-Br
6945FCH2—CH═CH—CH2Et-F2-Br, 4-Me
6946FCH2—CH═CH—CH2Et-F2-Br, 4-SnMe3
6947FCH2—CH═CH—CH2Et-F2-SnMe3, 4-Br
6948FCH2—CH═CH—CH2Et-F2-Me, 4-Br
6949FCH2—CH═CH—CH2Et-F2-Me, 4-SnMe3
6950FCH2—CH═CH—CH2Et-F2-SnMe3, 4-Me
6951FCH2—CH═CH—CH2Et-F2-Me, 4-Me
6952FCH2—CH═CH—CH2Et-F2-Et, 4-Br
6953FCH2—CH═CH—CH2Et-F2-Et, 4-SnMe3
6954FCH2—CH═CH—CH2Et-F2-Et, 4-Me
6955FCH2—CH═CH—CH2Et-F2-Me, 4-Me, 6-Me
6956FCH2—CH═CH—CH2Et-F2-Me, 4-Br, 6-Me
6957FCH2—CH═CH—CH2Et-F2-Me, 4-SnMe3, 6-Me
6958FCH2—CH═CH—CH2Et-F2-Et, 6-Me
6959FCH2—CH═CH—CH2Et-F2-Br, 4-i-Pr
6960FCH2—CH═CH—CH2Et-F2-SnMe3, 4-i-Pr
6961FCH2—CH═CH—CH2Et-F2-Me, 4-i-Pr
6962FCH2—CH═CH—CH2Et-F2-Br, 4-Br, 6-Br
6963FCH2—CH═CH—CH2Et-F2-Br, 4-Me, 6-Br
6964FCH2—CH═CH—CH2Et-F2-Br, 4-SnMe3, 6-Br
6965FCH2—CH═CH—CH2Et-F2-SnMe3, 4-Br, 6-Br
6966FCH2—CH═CH—CH2Et-F2-Br, 4-Br, 6-Me
6967FCH2—CH═CH—CH2Et-F2-Br, 4-CF3, 6-Br
6968FCH2—CH═CH—CH2Et-F2-Br, 4-Br, 6-CF3
6969FCH2—CH═CH—CH2Et-F2-CF3, 4-CF3
6970FCH2—CH═CH—CH2Et-F2-Cl, 4-CF3
6971FCH2—CH═CH—CH2Et-F2-CF3, 4-Cl
6972FCH2—CH═CH—CH2Et-F2-Br, 4-CF3
6973FCH2—CH═CH—CH2Et-F2-SnMe3, 4-CF3
6974FCH2—CH═CH—CH2Et-F2-Me, 4-CF3
6975FCH2—CH═CH—CH2Et-F2-CF3, 4-Br
6976FCH2—CH═CH—CH2Et-F2-CF3, 4-SnMe3
6977FCH2—CH═CH—CH2Et-F2-CF3, 4-Me
6978FCH2—CH═CH—CH2Et-F2-Br, 4-OH
6979FCH2—CH═CH—CH2Et-F2-Br, 4-OMe
6980FCH2—CH═CH—CH2Et-F2-Br, 4-OMeF
6981FCH2—CH═CH—CH2Et-F2-Br, 4-OCF3
6982FCH2—CH═CH—CH2Et-F2-Br, 4-OEtF
6983FCH2—CH═CH—CH2Et-F2-Br, 4-OPrF
6984FCH2—CH═CH—CH2Et-F2-OH, 4-Br
6985FCH2—CH═CH—CH2Et-F2-OMe, 4-Br
6986FCH2—CH═CH—CH2Et-F2-OMeF, 4-Br
6987FCH2—CH═CH—CH2Et-F2-OCF3, 4-Br
6988FCH2—CH═CH—CH2Et-F2-OEtF, 4-Br
6989FCH2—CH═CH—CH2Et-F2-OPrF, 4-Br
6990FCH2—CH═CH—CH2Et-F2-I, 4-OH
6991FCH2—CH═CH—CH2Et-F2-I, 4-OMe
6992FCH2—CH═CH—CH2Et-F2-I, 4-OMeF
6993FCH2—CH═CH—CH2Et-F2-I, 4-OCF3
6994FCH2—CH═CH—CH2Et-F2-I, 4-OEtF
6995FCH2—CH═CH—CH2Et-F2-I, 4-OPrF
6996FCH2—CH═CH—CH2Et-F2-OH, 4-I
6997FCH2—CH═CH—CH2Et-F2-OMe, 4-I
6998FCH2—CH═CH—CH2Et-F2-OMeF, 4-I
6999FCH2—CH═CH—CH2Et-F2-OCF3, 4-I
7000FCH2—CH═CH—CH2Et-F2-OEtF, 4-I
7001FCH2—CH═CH—CH2Et-F2-OPrF, 4-I
7002FCH2—CH═CH—CH2Et-F2-SnMe3, 4-OH
7003FCH2—CH═CH—CH2Et-F2-SnMe3, 4-OMe
7004FCH2—CH═CH—CH2Et-F2-SnMe3, 4-OMeF
7005FCH2—CH═CH—CH2Et-F2-SnMe3, 4-OCF3
7006FCH2—CH═CH—CH2Et-F2-SnMe3, 4-OEtF
7007FCH2—CH═CH—CH2Et-F2-SnMe3, 4-OPrF
7008FCH2—CH═CH—CH2Et-F2-OH, 2-SnMe3
7009FCH2—CH═CH—CH2Et-F2-OMe, 4-SnMe3
7010FCH2—CH═CH—CH2Et-F2-OMeF, 4-SnMe3
7011FCH2—CH═CH—CH2Et-F4-OCF3, 4-SnMe3
7012FCH2—CH═CH—CH2Et-F2-OEtF, 4-SnMe3
7013FCH2—CH═CH—CH2Et-F2-OPrF, 4-SnMe3

TABLE 6
Substituent list for compounds of general structure XI.
XI
embedded image
Compound
#R1 =R2 =R4 =X2 =
7014BuEtHH
7015BuEtHSnMe3
7016BuEtHBr
7017BuEtHI
7018BuEt4-FH
7019BuEt4-FSnMe3
7020BuEt4-FBr
7021BuEt4-FI
7022BuEt5-FH
7023BuEt5-FSnMe3
7024BuEt5-FBr
7025BuEt5-FI
7026BuEt4-ClH
7027BuEt4-ClSnMe3
7028BuEt4-ClBr
7029BuEt4-ClI
7030BuEt4-BrH
7031BuEt4-BrSnMe3
7032BuEt4-BrBr
7033BuEt4-BrI
7034BuEt4-MeH
7035BuEt4-MeSnMe3
7036BuEt4-MeBr
7037BuEt4-MeI
7038BuEt4-CF3H
7039BuEt4-CF3SnMe3
7040BuEt4-CF3Br
7041BuEt4-CF3I
7042BuEt4-OHH
7043BuEt4-OHSnMe3
7044BuEt4-OHBr
7045BuEt4-OHI
7046BuEt4-OMeH
7047BuEt4-OMeSnMe3
7048BuEt4-OMeBr
7049BuEt4-OMeI
7050BuEt4-OMeFH
7051BuEt4-OMeFSnMe3
7052BuEt4-OMeFBr
7053BuEt4-OMeFI
7054BuEt4-OCF3H
7055BuEt4-OCF3SnMe3
7056BuEt4-OCF3Br
7057BuEt4-OCF3I
7058BuEt4-OEtFH
7059BuEt4-OEtFSnMe3
7060BuEt4-OEtFBr
7061BuEt4-OEtFI
7062BuEt4-OPrFH
7063BuEt4-OPrFSnMe3
7064BuEt4-OPrFBr
7065BuEt4-OPrFI
7066BuEt4-i-PrH
7067BuEt4-i-PrSnMe3
7068BuEt4-i-PrBr
7069BuEt4-i-PrI
7070BuEt2-Br, 4-H
CF3
7071BuEt2-Br, 4-SnMe3
CF3
7072BuEt2-Br, 4-Br
CF3
7073BuEt2-Br, 4-I
CF3
7074BuEt2-CF3, 4-H
Br
7075BuEt2-CF3, 4-SnMe3
Br
7076BuEt2-CF3, 4-Br
Br
7077BuEt2-CF3, 4-I
Br
7078BuEt2-Br, 4-BrH
7079BuEt2-Br, 4-BrSnMe3
7080BuEt2-Br, 4-BrBr
7081BuEt2-Br, 4-BrI
7082BuEt2-Br, 4-H
Me
7083BuEt2-Br, 4-SnMe3
Me
7084BuEt2-Br, 4-Br
Me
7085BuEt2-Br, 4-I
Me
7086PrPrHH
7087PrPrHSnMe3
7088PrPrHBr
7089PrPrHI
7090PrPr4-FH
7091PrPr4-FSnMe3
7092PrPr4-FBr
7093PrPr4-FI
7094PrPr5-FH
7095PrPr5-FSnMe3
7096PrPr5-FBr
7097PrPr5-FI
7098PrPr4-ClH
7099PrPr4-ClSnMe3
7100PrPr4-ClBr
7101PrPr4-ClI
7102PrPr4-BrH
7103PrPr4-BrSnMe3
7104PrPr4-BrBr
7105PrPr4-BrI
7106PrPr4-MeH
7107PrPr4-MeSnMe3
7108PrPr4-MeBr
7109PrPr4-MeI
7110PrPr4-CF3H
7111PrPr4-CF3SnMe3
7112PrPr4-CF3Br
7113PrPr4-CF3I
7114PrPr4-OHH
7115PrPr4-OHSnMe3
7116PrPr4-OHBr
7117PrPr4-OHI
7118PrPr4-OMeH
7119PrPr4-OMeSnMe3
7120PrPr4-OMeBr
7121PrPr4-OMeI
7122PrPr4-OMeFH
7123PrPr4-OMeFSnMe3
7124PrPr4-OMeFBr
7125PrPr4-OMeFI
7126PrPr4-OCF3H
7127PrPr4-OCF3SnMe3
7128PrPr4-OCF3Br
7129PrPr4-OCF3I
7130PrPr4-OEtFH
7131PrPr4-OEtFSnMe3
7132PrPr4-OEtFBr
7133PrPr4-OEtFI
7134PrPr4-OPrFH
7135PrPr4-OPrFSnMe3
7136PrPr4-OPrFBr
7137PrPr4-OPrFI
7138PrPr4-i-PrH
7139PrPr4-i-PrSnMe3
7140PrPr4-i-PrBr
7141PrPr4-i-PrI
7142PrPr2-Br, 4-H
CF3
7143PrPr2-Br, 4-SnMe3
CF3
7144PrPr2-Br, 4-Br
CF3
7145PrPr2-Br, 4-I
CF3
7146PrPr2-CF3, 4-H
Br
7147PrPr2-CF3, 4-SnMe3
Br
7148PrPr2-CF3, 4-Br
Br
7149PrPr2-CF3, 4-I
Br
7150PrPr2-Br, 4-BrH
7151PrPr2-Br, 4-BrSnMe3
7152PrPr2-Br, 4-BrBr
7153PrPr2-Br, 4-BrI
7154PrPr2-Br, 4-H
Me
7155PrPr2-Br, 4-SnMe3
Me
7156PrPr2-Br, 4-Br
Me
7157PrPr2-Br, 4-I
Me
7158PrPr—FHH
7159PrPr—FHSnMe3
7160PrPr—FHBr
7161PrPr—FHI
7162PrPr—F4-FH
7163PrPr—F4-FSnMe3
7164PrPr—F4-FBr
7165PrPr—F4-FI
7166PrPr—F5-FH
7167PrPr—F5-FSnMe3
7168PrPr—F5-FBr
7169PrPr—F5-FI
7170PrPr—F4-ClH
7171PrPr—F4-ClSnMe3
7172PrPr—F4-ClBr
7173PrPr—F4-ClI
7174PrPr—F4-BrH
7175PrPr—F4-BrSnMe3
7176PrPr—F4-BrBr
7177PrPr—F4-BrI
7178PrPr—F4-MeH
7179PrPr—F4-MeSnMe3
7180PrPr—F4-MeBr
7181PrPr—F4-MeI
7182PrPr—F4-CF3H
7183PrPr—F4-CF3SnMe3
7184PrPr—F4-CF3Br
7185PrPr—F4-CF3I
7186PrPr—F4-OHH
7187PrPr—F4-OHSnMe3
7188PrPr—F4-OHBr
7189PrPr—F4-OHI
7190PrPr—F4-OMeH
7191PrPr—F4-OMeSnMe3
7192PrPr—F4-OMeBr
7193PrPr—F4-OMeI
7194PrPr—F4-OMeFH
7195PrPr—F4-OMeFSnMe3
7196PrPr—F4-OMeFBr
7197PrPr—F4-OMeFI
7198PrPr—F4-OCF3H
7199PrPr—F4-OCF3SnMe3
7200PrPr—F4-OCF3Br
7201PrPr—F4-OCF3I
7202PrPr—F4-OEtFH
7203PrPr—F4-OEtFSnMe3
7204PrPr—F4-OEtFBr
7205PrPr—F4-OEtFI
7206PrPr—F4-OPrFH
7207PrPr—F4-OPrFSnMe3
7208PrPr—F4-OPrFBr
7209PrPr—F4-OPrFI
7210PrPr—F4-i-PrH
7211PrPr—F4-i-PrSnMe3
7212PrPr—F4-i-PrBr
7213PrPr—F4-i-PrI
7214PrPr—F2-Br, 4-H
CF3
7215PrPr—F2-Br, 4-SnMe3
CF3
7216PrPr—F2-Br, 4-Br
CF3
7217PrPr—F2-Br, 4-I
CF3
7218PrPr—F2-CF3, 4-H
Br
7219PrPr—F2-CF3, 4-SnMe3
Br
7220PrPr—F2-CF3, 4-Br
Br
7221PrPr—F2-CF3, 4-I
Br
7222PrPr—F2-Br, 4-BrH
7223PrPr—F2-Br, 4-BrSnMe3
7224PrPr—F2-Br, 4-BrBr
7225PrPr—F2-Br, 4-BrI
7226PrPr—F2-Br, 4-H
Me
7227PrPr—F2-Br, 4-SnMe3
Me
7228PrPr—F2-Br, 4-Br
Me
7229PrPr—F2-Br, 4-I
Me
7230PrEt—FHH
7231PrEt—FHSnMe3
7232PrEt—FHBr
7233PrEt—FHI
7234PrEt—F4-FH
7235PrEt—F4-FSnMe3
7236PrEt—F4-FBr
7237PrEt—F4-FI
7238PrEt—F5-FH
7239PrEt—F5-FSnMe3
7240PrEt—F5-FBr
7241PrEt—F5-FI
7242PrEt—F4-ClH
7243PrEt—F4-ClSnMe3
7244PrEt—F4-ClBr
7245PrEt—F4-ClI
7246PrEt—F4-BrH
7247PrEt—F4-BrSnMe3
7248PrEt—F4-BrBr
7249PrEt—F4-BrI
7250PrEt—F4-MeH
7251PrEt—F4-MeSnMe3
7252PrEt—F4-MeBr
7253PrEt—F4-MeI
7254PrEt—F4-CF3H
7255PrEt—F4-CF3SnMe3
7256PrEt—F4-CF3Br
7257PrEt—F4-CF3I
7258PrEt—F4-OHH
7259PrEt—F4-OHSnMe3
7260PrEt—F4-OHBr
7261PrEt—F4-OHI
7262PrEt—F4-OMeH
7263PrEt—F4-OMeSnMe3
7264PrEt—F4-OMeBr
7265PrEt—F4-OMeI
7266PrEt—F4-OMeFH
7267PrEt—F4-OMeFSnMe3
7268PrEt—F4-OMeFBr
7269PrEt—F4-OMeFI
7270PrEt—F4-OCF3H
7271PrEt—F4-OCF3SnMe3
7272PrEt—F4-OCF3Br
7273PrEt—F4-OCF3I
7274PrEt—F4-OEtFH
7275PrEt—F4-OEtFSnMe3
7276PrEt—F4-OEtFBr
7277PrEt—F4-OEtFI
7278PrEt—F4-OPrFH
7279PrEt—F4-OPrFSnMe3
7280PrEt—F4-OPrFBr
7281PrEt—F4-OPrFI
7282PrEt—F4-i-PrH
7283PrEt—F4-i-PrSnMe3
7284PrEt—F4-i-PrBr
7285PrEt—F4-i-PrI
7286PrEt—F2-Br, 4-H
CF3
7287PrEt—F2-Br, 4-SnMe3
CF3
7288PrEt—F2-Br, 4-Br
CF3
7289PrEt—F2-Br, 4-I
CF3
7290PrEt—F2-CF3, 4-H
Br
7291PrEt—F2-CF3, 4-SnMe3
Br
7292PrEt—F2-CF3, 4-Br
Br
7293PrEt—F2-CF3, 4-I
Br
7294PrEt—F2-Br, 4-BrH
7295PrEt—F2-Br, 4-BrSnMe3
7296PrEt—F2-Br, 4-BrBr
7297PrEt—F2-Br, 4-BrI
7298PrEt—F2-Br, 4-H
Me
7299PrEt—F2-Br, 4-SnMe3
Me
7300PrEt—F2-Br, 4-Br
Me
7301PrEt—F2-Br, 4-I
Me
7302Pr—FEtHH
7303Pr—FEtHSnMe3
7304Pr—FEtHBr
7305Pr—FEtHI
7306Pr—FEt4-FH
7307Pr—FEt4-FSnMe3
7308Pr—FEt4-FBr
7309Pr—FEt4-FI
7310Pr—FEt5-FH
7311Pr—FEt5-FSnMe3
7312Pr—FEt5-FBr
7313Pr—FEt5-FI
7314Pr—FEt4-ClH
7315Pr—FEt4-ClSnMe3
7316Pr—FEt4-ClBr
7317Pr—FEt4-ClI
7318Pr—FEt4-BrH
7319Pr—FEt4-BrSnMe3
7320Pr—FEt4-BrBr
7321Pr—FEt4-BrI
7322Pr—FEt4-MeH
7323Pr—FEt4-MeSnMe3
7324Pr—FEt4-MeBr
7325Pr—FEt4-MeI
7326Pr—FEt4-CF3H
7327Pr—FEt4-CF3SnMe3
7328Pr—FEt4-CF3Br
7329Pr—FEt4-CF3I
7330Pr—FEt4-OHH
7331Pr—FEt4-OHSnMe3
7332Pr—FEt4-OHBr
7333Pr—FEt4-OHI
7334Pr—FEt4-OMeH
7335Pr—FEt4-OMeSnMe3
7336Pr—FEt4-OMeBr
7337Pr—FEt4-OMeI
7338Pr—FEt4-OMeFH
7339Pr—FEt4-OMeFSnMe3
7340Pr—FEt4-OMeFBr
7341Pr—FEt4-OMeFI
7342Pr—FEt4-OCF3H
7343Pr—FEt4-OCF3SnMe3
7344Pr—FEt4-OCF3Br
7345Pr—FEt4-OCF3I
7346Pr—FEt4-OEtFH
7347Pr—FEt4-OEtFSnMe3
7348Pr—FEt4-OEtFBr
7349Pr—FEt4-OEtFI
7350Pr—FEt4-OPrFH
7351Pr—FEt4-OPrFSnMe3
7352Pr—FEt4-OPrFBr
7353Pr—FEt4-OPrFI
7354Pr—FEt4-i-PrH
7355Pr—FEt4-i-PrSnMe3
7356Pr—FEt4-i-PrBr
7357Pr—FEt4-i-PrI
7358Pr—FEt2-Br, 4-H
CF3
7359Pr—FEt2-Br, 4-SnMe3
CF3
7360Pr—FEt2-Br, 4-Br
CF3
7361Pr—FEt2-Br, 4-I
CF3
7362Pr—FEt2-CF3, 4-H
Br
7363Pr—FEt2-CF3, 4-SnMe3
Br
7364Pr—FEt2-CF3, 4-Br
Br
7365Pr—FEt2-CF3, 4-I
Br
7366Pr—FEt2-Br, 4-BrH
7367Pr—FEt2-Br, 4-BrSnMe3
7368Pr—FEt2-Br, 4-BrBr
7369Pr—FEt2-Br, 4-BrI
7370Pr—FEt2-Br, 4-H
Me
7371Pr—FEt2-Br, 4-SnMe3
Me
7372Pr—FEt2-Br, 4-Br
Me
7373Pr—FEt2-Br, 4-I
Me
7374BuEt—FHH
7375BuEt—FHSnMe3
7376BuEt—FHBr
7377BuEt—FHI
7378BuEt—F4-FH
7379BuEt—F4-FSnMe3
7380BuEt—F4-FBr
7381BuEt—F4-FI
7382BuEt—F5-FH
7383BuEt—F5-FSnMe3
7384BuEt—F5-FBr
7385BuEt—F5-FI
7386BuEt—F4-ClH
7387BuEt—F4-ClSnMe3
7388BuEt—F4-ClBr
7389BuEt—F4-ClI
7390BuEt—F4-BrH
7391BuEt—F4-BrSnMe3
7392BuEt—F4-BrBr
7393BuEt—F4-BrI
7394BuEt—F4-MeH
7395BuEt—F4-MeSnMe3
7396BuEt—F4-MeBr
7397BuEt—F4-MeI
7398BuEt—F4-CF3H
7399BuEt—F4-CF3SnMe3
7400BuEt—F4-CF3Br
7401BuEt—F4-CF3I
7402BuEt—F4-OHH
7403BuEt—F4-OHSnMe3
7404BuEt—F4-OHBr
7405BuEt—F4-OHI
7406BuEt—F4-OMeH
7407BuEt—F4-OMeSnMe3
7408BuEt—F4-OMeBr
7409BuEt—F4-OMeI
7410BuEt—F4-OMeFH
7411BuEt—F4-OMeFSnMe3
7412BuEt—F4-OMeFBr
7413BuEt—F4-OMeFI
7414BuEt—F4-OCF3H
7415BuEt—F4-OCF3SnMe3
7416BuEt—F4-OCF3Br
7417BuEt—F4-OCF3I
7418BuEt—F4-OEtFH
7419BuEt—F4-OEtFSnMe3
7420BuEt—F4-OEtFBr
7421BuEt—F4-OEtFI
7422BuEt—F4-OPrFH
7423BuEt—F4-OPrFSnMe3
7424BuEt—F4-OPrFBr
7425BuEt—F4-OPrFI
7426BuEt—F4-i-PrH
7427BuEt—F4-i-PrSnMe3
7428BuEt—F4-i-PrBr
7429BuEt—F4-i-PrI
7430BuEt—F2-Br, 4-H
CF3
7431BuEt—F2-Br, 4-SnMe3
CF3
7432BuEt—F2-Br, 4-Br
CF3
7433BuEt—F2-Br, 4-I
CF3
7434BuEt—F2-CF3, 4-H
Br
7435BuEt—F2-CF3, 4-SnMe3
Br
7436BuEt—F2-CF3, 4-Br
Br
7437BuEt—F2-CF3, 4-I
Br
7438BuEt—F2-Br, 4-BrH
7439BuEt—F2-Br, 4-BrSnMe3
7440BuEt—F2-Br, 4-BrBr
7441BuEt—F2-Br, 4-BrI
7442BuEt—F2-Br, 4-H
Me
7443BuEt—F2-Br, 4-SnMe3
Me
7444BuEt—F2-Br, 4-Br
Me
7445BuEt—F2-Br, 4-I
Me
7446Bu—FEtHH
7447Bu—FEtHSnMe3
7448Bu—FEtHBr
7449Bu—FEtHI
7450Bu—FEt4-FH
7451Bu—FEt4-FSnMe3
7452Bu—FEt4-FBr
7453Bu—FEt4-FI
7454Bu—FEt5-FH
7455Bu—FEt5-FSnMe3
7456Bu—FEt5-FBr
7457Bu—FEt5-FI
7458Bu—FEt4-ClH
7459Bu—FEt4-ClSnMe3
7460Bu—FEt4-ClBr
7461Bu—FEt4-ClI
7462Bu—FEt4-BrH
7463Bu—FEt4-BrSnMe3
7464Bu—FEt4-BrBr
7465Bu—FEt4-BrI
7466Bu—FEt4-MeH
7467Bu—FEt4-MeSnMe3
7468Bu—FEt4-MeBr
7469Bu—FEt4-MeI
7470Bu—FEt4-CF3H
7471Bu—FEt4-CF3SnMe3
7472Bu—FEt4-CF3Br
7473Bu—FEt4-CF3I
7474Bu—FEt4-OHH
7475Bu—FEt4-OHSnMe3
7476Bu—FEt4-OHBr
7477Bu—FEt4-OHI
7478Bu—FEt4-OMeH
7479Bu—FEt4-OMeSnMe3
7480Bu—FEt4-OMeBr
7481Bu—FEt4-OMeI
7482Bu—FEt4-OMeFH
7483Bu—FEt4-OMeFSnMe3
7484Bu—FEt4-OMeFBr
7485Bu—FEt4-OMeFI
7486Bu—FEt4-OCF3H
7487Bu—FEt4-OCF3SnMe3
7488Bu—FEt4-OCF3Br
7489Bu—FEt4-OCF3I
7490Bu—FEt4-OEtFH
7191Bu—FEt4-OEtFSnMe3
7492Bu—FEt4-OEtFBr
7493Bu—FEt4-OEtFI
7494Bu—FEt4-OPrFH
7495Bu—FEt4-OPrFSnMe3
7496Bu—FEt4-OPrFBr
7497Bu—FEt4-OPrFI
7498Bu—FEt4-i-PrH
7499Bu—FEt4-i-PrSnMe3
7500Bu—FEt4-i-PrBr
7501Bu—FEt4-i-PrI
7502Bu—FEt2-Br, 4-H
CF3
7503Bu—FEt2-Br, 4-SnMe3
CF3
7504Bu—FEt2-Br, 4-Br
CF3
7505Bu—FEt2-Br, 4-I
CF3
7506Bu—FEt2-CF3, 4-H
Br
7507Bu—FEt2-CF3, 4-SnMe3
Br
7508Bu—FEt2-CF3, 4-Br
Br
7509Bu—FEt2-CF3, 4-I
Br
7510Bu—FEt2-Br, 4-BrH
7511Bu—FEt2-Br, 4-BrSnMe3
7512Bu—FEt2-Br, 4-BrBr
7513Bu—FEt2-Br, 4-BrI
7514Bu—FEt2-Br, 4-H
Me
7515Bu—FEt2-Br, 4-SnMe3
Me
7516Bu—FEt2-Br, 4-Br
Me
7517Bu—FEt2-Br, 4-I
Me
7518FCH2—CH═CH—CH2MeHH
7519FCH2—CH═CH—CH2MeHSnMe3
7520FCH2—CH═CH—CH2MeHBr
7521FCH2—CH═CH—CH2MeHI
7522FCH2—CH═CH—CH2Me4-FH
7523FCH2—CH═CH—CH2Me4-FSnMe3
7524FCH2—CH═CH—CH2Me4-FBr
7525FCH2—CH—CH—CH2Me4-FI
7526FCH2—CH═CH—CH2Me5-FH
7527FCH2—CH═CH—CH2Me5-FSnMe3
7528FCH2—CH═CH—CH2Me5-FBr
7529FCH2—CH═CH—CH2Me5-FI
7530FCH2—CH═CH—CH2Me4-ClH
7531FCH2—CH═CH—CH2Me4-ClSnMe3
7532FCH2—CH═CH—CH2Me4-ClBr
7533FCH2—CH═CH—CH2Me4-ClI
7534FCH2—CH═CH—CH2Me4-BrH
7535FCH2—CH═CH—CH2Me4-BrSnMe3
7536FCH2—CH═CH—CH2Me4-BrBr
7537FCH2—CH═CH—CH2Me4-BrI
7538FCH2—CH═CH—CH2Me4-MeH
7539FCH2—CH═CH—CH2Me4-MeSnMe3
7540FCH2—CH═CH—CH2Me4-MeBr
7541FCH2—CH═CH—CH2Me4-MeI
7542FCH2—CH═CH—CH2Me4-CF3H
7543FCH2—CH═CH—CH2Me4-CF3SnMe3
7544FCH2—CH═CH—CH2Me4-CF3Br
7545FCH2—CH═CH—CH2Me4-CF3I
7546FCH2—CH═CH—CH2Me4-OHH
7547FCH2—CH═CH—CH2Me4-OHSnMe3
7548FCH2—CH═CH—CH2Me4-OHBr
7549FCH2—CH═CH—CH2Me4-OHI
7550FCH2—CH═CH—CH2Me4-OMeH
7551FCH2—CH═CH—CH2Me4-OMeSnMe3
7552FCH2—CH═CH—CH2Me4-OMeBr
7553FCH2—CH—CH—CH2Me4-OMeI
7554FCH2—CH═CH—CH2Me4-OMeFH
7555FCH2—CH═CH—CH2Me4-OMeFSnMe3
7556FCH2—CH═CH—CH2Me4-OMeFBr
7557FCH2—CH═CH—CH2Me4-OMeFI
7558FCH2—CH═CH—CH2Me4-OCF3H
7559FCH2—CH═CH—CH2Me4-OCF3SnMe3
7560FCH2—CH═CH—CH2Me4-OCF3Br
7561FCH2—CH═CH—CH2Me4-OCF3I
7562FCH2—CH═CH—CH2Me4-OEtFH
7563FCH2—CH═CH—CH2Me4-OEtFSnMe3
7564FCH2—CH═CH—CH2Me4-OEtFBr
7565FCH2—CH═CH—CH2Me4-OEtFI
7566FCH2—CH═CH—CH2Me4-OPrFH
7567FCH2—CH═CH—CH2Me4-OPrFSnMe3
7568FCH2—CH═CH—CH2Me4-OPrFBr
7569FCH2—CH═CH—CH2Me4-OPrFI
7570FCH2—CH═CH—CH2Me4-i-PrH
7571FCH2—CH═CH—CH2Me4-i-PrSnMe3
7572FCH2—CH═CH—CH2Me4-i-PrBr
7573FCH2—CH═CH—CH2Me4-i-PrI
7574FCH2—CH═CH—CH2Me2-Br, 4-H
CF3
7575FCH2—CH═CH—CH2Me2-Br, 4-SnMe3
CF3
7576FCH2—CH═CH—CH2Me2-Br, 4-Br
CF3
7577FCH2—CH═CH—CH2Me2-Br, 4-I
CF3
7578FCH2—CH═CH—CH2Me2-CF3, 4-H
Br
7579FCH2—CH═CH—CH2Me2-CF3, 4-SnMe3
Br
7580FCH2—CH═CH—CH2Me2-CF3, 4-Br
Br
7581FCH2—CH═CH—CH2Me2-CF3, 4-I
Br
7582FCH2—CH═CH—CH2Me2-Br, 4-BrH
7583FCH2—CH═CH—CH2Me2-Br, 4-BrSnMe3
7584FCH2—CH═CH—CH2Me2-Br, 4-BrBr
7585FCH2—CH═CH—CH2Me2-Br, 4-BrI
7586FCH2—CH═CH—CH2Me2-Br, 4-H
Me
7587FCH2—CH═CH—CH2Me2-Br, 4-SnMe3
Me
7588FCH2—CH═CH—CH2Me2-Br, 4-BI-
Me
7589FCH2—CH═CH—CH2Me2-Br, 4-I
Me
7590FCH2—CH═CH—CH2EtHPI
7591FCH2—CH═CH—CH2EtHSnMe3
7592FCH2—CH═CH—CH2EtHBr
7593FCH2—CH═CH—CH2EtHI
7594FCH2—CH═CH—CH2Et4-FH
7595FCH2—CH═CH—CH2Et4-FSnMe3
7596FCH2—CH═CH—CH2Et4-FBr
7597FCH2—CH═CH—CH2Et4-FI
7598FCH2—CH═CH—CH2Et5-FH
7599FCH2—CH═CH—CH2Et5-FSnMe3
7600FCH2—CH═CH—CH2Et5-FBr
7601FCH2—CH═CH—CH2Et5-FI
7602FCH2—CH═CH—CH2Et4-ClH
7603FCH2—CH═CH—CH2Et4-ClSnMe3
7604FCH2—CH═CH—CH2Et4-ClBr
7605FCH2—CH═CH—CH2Et4-ClI
7606FCH2—CH═CH—CH2Et4-BrH
7607FCH2—CH═CH—CH2Et4-BrSnMe3
7608FCH2—CH═CH—CH2Et4-BrBr
7609FCH2—CH═CH—CH2Et4-BrI
7610FCH2—CH═CH—CH2Et4-MeH
7611FCH2—CH═CH—CH2Et4-MeSnMe3
7612FCH2—CH═CH—CH2Et4-MeBr
7613FCH2—CH═CH—CH2Et4-MeI
7614FCH2—CH═CH—CH2Et4-CF3H
7615FCH2—CH═CH—CH2Et4-CF3SnMe3
7616FCH2—CH═CH—CH2Et4-CF3Br
7617FCH2—CH═CH—CH2Et4-CF3I
7618FCH2—CH═CH—CH2Et4-OHH
7619FCH2—CH═CH—CH2Et4-OHSnMe3
7620FCH2—CH═CH—CH2Et4-OHBr
7621FCH2—CH═CH—CH2Et4-OHI
7622FCH2—CH═CH—CH2Et4-OMeH
7623FCH2—CH═CH—CH2Et4-OMeSnMe3
7624FCH2—CH═CH—CH2Et4-OMeBr
7625FCH2—CH═CH—CH2Et4-OMeI
7626FCH2—CH═CH—CH2Et4-OMeFH
7627FCH2—CH═CH—CH2Et4-OMeFSnMe3
7628FCH2—CH═CH—CH2Et4-OMeFBr
7629FCH2—CH═CH—CH2Et4-OMeFI
7630FCH2—CH═CH—CH2Et4-OCF3H
7631FCH2—CH═CH—CH2Et4-OCF3SnMe3
7632FCH2—CH═CH—CH2Et4-OCF3Br
7633FCH2—CH═CH—CH2Et4-OCF3I
7634FCH2—CH═CH—CH2Et4-OEtFH
7635FCH2—CH═CH—CH2Et4-OEtFSnMe3
7636FCH2—CH═CH—CH2Et4-OEtFBr
7637FCH2—CH═CH—CH2Et4-OEtFI
7638FCH2—CH═CH—CH2Et4-OPrFH
7639FCH2—CH═CH—CH2Et4-OPrFSnMe3
7640FCH2—CH═CH—CH2Et4-OPrFBr
7641FCH2—CH═CH—CH2Et4-OPrFI
7642FCH2—CH═CH—CH2Et4-i-PrH
7643FCH2—CH═CH—CH2Et4-i-PrSnMe3
7644FCH2—CH═CH—CH2Et4-i-PrBr
7645FCH2—CH═CH—CH2Et4-i-PrI
7646FCH2—CH═CH—CH2Et2-Br, 4-H
CF3
7647FCH2—CH═CH—CH2Et2-Br, 4-SnMe3
CF3
7648FCH2—CH═CH—CH2Et2-Br, 4-Br
CF3
7649FCH2—CH═CH—CH2Et2-Br, 4-I
CF3
7650FCH2—CH═CH—CH2Et2-CFI, 4-H
Br
7651FCH2—CH═CH—CH2Et2-CF3, 4-SnMe3
Br
7652FCH2—CH═CH—CH2Et2-CF3, 4-Br
Br
7653FCH2—CH═CH—CH2Et2-CF3, 4-I
Br
7654FCH2—CH═CH—CH2Et2-Br, 4-BrH
7655FCH2—CH═CH—CH2Et2-Br, 4-BrSnMe3
7656FCH2—CH═CH—CH2Et2-Br, 4-BrBr
7657FCH2—CH═CH—CH2Et2-Br, 4-BrI
7658FCH2—CH═CH—CH2Et2-Br, 4-H
Me
7659FCH2—CH═CH—CH2Et2-Br, 4-SnMe3
Me
7660FCH2—CH═CH—CH2Et2-Br, 4-Br
Me
7661FCH2—CH═CH—CH2Et2-Br, 4-I
Me
7662FCH2—CH═CH—CH2Et—FHH
7663FCH2—CH═CH—CH2Et—FHSnMe3
7664FCH2—CH═CH—CH2Et—FHBr
7665FCH2—CH═CH—CH2Et—FHI
7666FCH2—CH═CH—CH2Et—F4-FH
7667FCH2—CH═CH—CH2Et—F4-FSnMe3
7668FCH2—CH═CH—CH2Et—F4-FBr
7669FCH2—CH═CH—CH2Et—F4-FI
7670FCH2—CH═CH—CH2Et—F5-FH
7671FCH2—CH═CH—CH2Et—F5-FSnMe3
7672FCH2—CH═CH—CH2Et—F5-FBr
7673FCH2—CH═CH—CH2Et—F5-FI
7674FCH2—CH═CH—CH2Et—F4-ClH
7675FCH2—CH═CH—CH2Et—F4-ClSnMe3
7676FCH2—CH═CH—CH2Et—F4-ClBr
7677FCH2—CH═CH—CH2Et—F4-ClI
7678FCH2—CH═CH—CH2Et—F4-BrH
7679FCH2—CH═CH—CH2Et—F4-BrSnMe3
7680FCH2—CH═CH—CH2Et—F4-BrBr
7681FCH2—CH═CH—CH2Et—F4-BrI
7682FCH2—CH═CH—CH2Et—F4-MeH
7683FCH2—CH═CH—CH2Et—F4-MeSnMe3
7684FCH2—CH═CH—CH2Et—F4-MeBr
7685FCH2—CH═CH—CH2Et—F4-MeI
7686FCH2—CH═CH—CH2Et—F4-CF3H
7687FCH2—CH═CH—CH2Et—F4-CF3SnMe3
7688FCH2—CH═CH—CH2Et—F4-CF3Br
7689FCH2—CH═CH—CH2Et—F4-CF3I
7690FCH2—CH═CH—CH2Et—F4-OHH
7691FCH2—CH═CH—CH2Et—F4-OHSnMe3
7692FCH2—CH═CH—CH2Et—F4-OHBr
7693FCH2—CH═CH—CH2Et—F4-OHI
7694FCH2—CH═CH—CH2Et—F4-OMeH
7695FCH2—CH═CH—CH2Et—F4-OMeSnMe3
7696FCH2—CH═CH—CH2Et—F4-OMeBr
7697FCH2—CH═CH—CH2Et—F4-OMeI
7698FCH2—CH═CH—CH2Et—F4-OMeFH
7699FCH2—CH═CH—CH2Et—F4-UMel,SnMe3
7700FCH2—CH═CH—CH2Et—F4-OMeFBr
7701FCH2—CH═CH—CH2Et—F4-OMeFI
7702FCH2—CH═CH—CH2Et—F4-OCF3H
7703FCH2—CH═CH—CH2Et—F4-OCF3SnMe3
7704FCH2—CH═CH—CH2Et—F4-OCF3Br
7705FCH2—CH═CH—CH2Et—F4-OCF3I
7706FCH2—CH═CH—CH2Et—F4-OEtFH
7707FCH2—CH═CH—CH2Et—F4-OEtFSnMe3
7708FCH2—CH═CH—CH2Et—F4-OEtFBr
7709FCH2—CH═CH—CH2Et—F4-OEtFI
7710FCH2—CH═CH—CH2Et—F4-OPrFH
7711FCH2—CH═CH—CH2Et—F4-OPrFSnMe3
7712FCH2—CH═CH—CH2Et—F4-OPrFBr
7713FCH2—CH═CH—CH2Et—F4-OPrFI
7714FCH2—CH═CH—CH2Et—F4-i-PrH
7715FCH2—CH═CH—CH2Et—F4-i-PrSnMe3
7716FCH2—CH═CH—CH2Et—F4-i-PrBr
7717FCH2—CH═CH—CH2Et—F4-i-PrI
7718FCH2—CH═CH—CH2Et—F2-Br, 4-H
CF3
7719FCH2—CH═CH—CH2Et—F2-Br, 4-SnMe3
CF3
7720FCH2—CH═CH—CH2Et—F2-Br, 4-Br
CF3
7721FCH2—CH═CH—CH2Et—F2-Br, 4-I
CF3
7722FCH2—CH═CH—CH2Et—F2-CF3, 4-H
Br
7723FCH2—CH═CH—CH2Et—F2-CF3, 4-SnMe3
Br
7724FCH2—CH═CH—CH2Et—F2-CF3, 4-Br
Br
7725FCH2—CH═CH—CH2Et—F2-CF3, 4-I
Br
7726FCH2—CH═CH—CH2Et—F2-Br, 4-BrH
7727FCH2—CH═CH—CH2Et—F2-Br, 4-BrSnMe3
7728FCH2—CH═CH—CH2Et—F2-Br, 4-BrBr
7729FCH2—CH═CH—CH2Et—F2-Br, 4-BrI
7730FCH2—CH═CH—CH2Et—F2-Br, 4-H
Me
7731FCH2—CH═CH—CH2Et—F2-Br, 4-SnMe3
Me
7732FCH2—CH═CH—CH2Et—F2-Br, 4-Br
Me
7733FCH2—CH═CH—CH2Et—F2-Br, 4-I
Me

TABLE 7
Substituent list for compounds of general structure XII.
XII
embedded image
Compound #R1 R2 =R5 =X2 =
7734BuEtHH
7735BuEtHSnMe3
7736BuEtHBr
7737BuEtHI
7738BuEt2-FH
7739BuEt2-FSnMe3
7740BuEt2-FBr
7741BuEt2-FI
7742BuEt2-ClH
7743BuEt2-ClSnMe3
7744BuEt2-ClBr
7745BuEt2-ClI
7746BuEt2-BrH
7747BuEt2-BrSnMe3
7748BuEt2-BrBr
7749BuEt2-BrI
7750BuEt2-MeH
7751BuEt2-MeSnMe3
7752BuEt2-MeBr
7753BuEt2-MeI
7754BuEt2-EtH
7755BuEt2-EtSnMe3
7756BuEt2-EtBr
7757BuEt2-EtI
7758BuEt2-Me,H
6-Me
7759BuEt2-Me,SnMe3
6-Me
7760BuEt2-Me,Br
6-Me
7761BuEt2-Me,I
6-Me
7762BuEt2-OHH
7763BuEt2-OHSnMe3
7764BuEt2-OHBr
7765BuEt2-OHI
7766BuEt2-OMeH
7767BuEt2-OMeSnMe3
7768BuEt2-OMeBr
7769BuEt2-OMeI
7770BuEt2-H
OMeF
7771BuEt2-SnMe3
OMeF
7772BuEt2-Br
OMeF
7773BuEt2-I
OMeF
7774BuEt2-OCF3H
7775BuEt2-OCF3SnMe3
7776BuEt2-OCF3Br
7777BuEt2-OCF3I
7778BuEt2-OEtFH
7779BuEt2-OEtFSnMe3
7780BuEt2-OEtFBr
7781BuEt2-OEtFI
7782BuEt2-OPrFH
7783BuEt2-OPrFSnMe3
7784BuEt2-OPrFBr
7785BuEt2-OPrFI
7786BuEt2-CF3H
7787BuEt2-CF3SnMe3
7788BuEt2-CF3Br
7789BuEt2-CF3I
7790BuEt2-Br, 6-H
CF3
7791BuEt2-Br, 6-SnMe3
CF3
7792BuEt2-Br, 6-Br
CF3
7793BuEt2-Br, 6-I
CF3
7794BuEt2-Br, 6-H
Br
7795BuEt2-Br, 6-SnMe3
Br
7796BuEt2-Br, 6-Br
Br
7797BuEt2-Br, 6-I
Br
7798PrPrHH
7799PrPrHSnMe3
7800PrPrHBr
7801PrPrHI
7802PrPr2-FH
7803PrPr2-FSnMe3
7804PrPr2-FBr
7805PrPr2-FI
7806PrPr2-ClH
7807PrPr2-ClSnMe3
7808PrPr2-ClBr
7809PrPr2-ClI
7810PrPr2-BrH
7811PrPr2-BrSnMe3
7812PrPr2-BrBr
7813PrPr2-BrI
7814PrPr2-MeH
7815PrPr2-MeSnMe3
7816PrPr2-MeBr
7817PrPr2-MeI
7818PrPr2-EtH
7819PrPr2-EtSnMe3
7820PrPr2-EtBr
7821PrPr2-EtI
7822PrPr2-Me,H
6-Me
7823PrPr2-Me,SnMe3
6-Me
7824PrPr2-Me,Br
6-Me
7825PrPr2-Me,I
6-Me
7826PrPr2-OHH
7827PrPr2-OHSnMe3
7828PrPr2-OHBr
7829PrPr2-OHI
7830PrPr2-OMeH
7831PrPr2-OMeSnMe3
7832PrPr2-OMeBr
7833PrPr2-OMeI
7834PrPr2-H
OMeF
7835PrPr2-SnMe3
OMeF
7836PrPr2-Br
OMeF
7837PrPr2-I
OMeF
7838PrPr2-OCF3H
7839PrPr2-OCF3SnMe3
7840PrPr2-OCF3Br
7841PrPr2-OCF3I
7842PrPr2-OEtFH
7843PrPr2-OEtFSnMe3
7844PrPr2-OEtFBr
7845PrPr2-OEtFI
7846PrPr2-OPrFH
7847PrPr2-OPrFSnMe3
7848PrPr2-OPrFBr
7849PrPr2-OPrFI
7850PrPr2-CF3H
7851PrPr2-CF3SnMe3
7852PrPr2-CF3Br
7853PrPr2-CF3I
7854PrPr2-Br, 6-H
CF3
7855PrPr2-Br, 6-SnMe3
CF3
7856PrPr2-Br, 6-Br
CF3
7857PrPr2-Br, 6-I
CF3
7858PrPr2-Br, 6-H
Br
7859PrPr2-Br, 6-SnMe3
Br
7860PrPr2-Br, 6-Br
Br
7861PrPr2-Br, 6-I
Br
7862PrPr—FHH
7863PrPr—FHSnMe3
7864PrPr—FHBr
7865PrPr—FHI
7866PrPr—F2-FH
7867PrPr—F2-FSnMe3
7868PrPr—F2-FBr
7869PrPr—F2-FI
7870PrPr—F2-ClH
7871PrPr—F2-ClSnMe3
7872PrPr—F2-ClBr
7873PrPr—F2-ClI
7874PrPr—F2-BrH
7875PrPr—F2-BrSnMe3
7876PrPr—F2-BrBr
7877PrPr—F2-BrI
7878PrPr—F2-MeH
7879PrPr—F2-MeSnMe3
7880PrPr—F2-MeBr
7881PrPr—F2-MeI
7882PrPr—F2-EtH
7883PrPr—F2-EtSnMe3
7884PrPr—F2-EtBr
7885PrPr—F2-EtI
7886PrPr—F2-Me,H
6-Me
7887PrPr—F2-Me,SnMe3
6-Me
7888PrPr—F2-Me,Br
6-Me
7889PrPr—F2-Me,I
6-Me
7890PrPr—F2-OHH
7891PrPr—F2-OHSnMe3
7892PrPr—F2-OHBr
7893PrPr—F2-OHI
7894PrPr—F2-OMeH
7895PrPr—F2-OMeSnMe3
7896PrPr—F2-OMeBr
7897PrPr—F2-OMeI
7898PrPr—F2-H
OMeF
7899PrPr—F2-SnMe3
OMeF
7900PrPr—F2-Br
OMeF
7901PrPr—F2-I
OMeF
7902PrPr—F2-OCF3H
7903PrPr—F2-OCF3SnMe3
7904PrPr—F2-OCF3Br
7905PrPr—F2-OCF3I
7906PrPr—F2-OEtFH
7907PrPr—F2-OEtFSnMe3
7908PrPr—F2-OEtFBr
7909PrPr—F2-OEtFI
7910PrPr—F2-OPrFH
7911PrPr—F2-OPrFSnMe3
7912PrPr—F2-OPrFBr
7913PrPr—F2-OPrFI
7914PrPr—F2-CF3H
7915PrPr—F2-CF3SnMe3
7916PrPr—F2-CF3Br
7917PrPr—F2-CF3I
7918PrPr—F2-Br, 6-H
CF3
7919PrPr—F2-Br, 6-SnMe3
CF3
7920PrPr—F2-Br, 6-Br
CF3
7921PrPr—F2-Br, 6-I
CF3
7922PrPr—F2-Br, 6-H
Br
7923PrPr—F2-Br, 6-SnMe3
Br
7924PrPr—F2-Br, 6-Br
Br
7925PrPr—F2-Br, 6-I
Br
7926PrEt—FHH
7927PrEt—FHSnMe3
7928PrEt—FHBr
7929PrEt—FHI
7930PrEt—F2-FH
7931PrEt—F2-FSnMe3
7932PrEt—F2-FBr
7933PrEt—F2-FI
7934PrEt—F2-ClH
7935PrEt—F2-ClSnMe3
7936PrEt—F2-ClBr
7937PrEt—F2-ClI
7938PrEt—F2-BrH
7939PrEt—F2-BrSnMe3
7940PrEt—F2-BrBr
7941PrEt—F2-BrI
7942PrEt—F2-MeH
7943PrEt—F2-MeSnMe3
7944PrEt—F2-MeBr
7945PrEt—F2-MeI
7946PrEt—F2-EtH
7947PrEt—F2-EtSnMe3
7948PrEt—F2-EtBr
7949PrEt—F2-EtI
7950PrEt—F2-Me,H
6-Me
7951PrEt—F2-Me,SnMe3
6-Me
7952PrEt—F2-Me,Br
6-Me
7953PrEt—F2-Me,I
6-Me
7954PrEt—F2-OHH
7955PrEt—F2-OHSnMe3
7956PrEt—F2-OHBr
7957PrEt—F2-OHI
7958PrEt—F2-OMeH
7959PrEt—F2-OMeSnMe3
7960PrEt—F2-OMeBr
7961PrEt—F2-OMeI
7962PrEt—F2-H
OMeF
7963PrEt—F2-SnMe3
OMeF
7964PrEt—F2-Br
OMeF
7965PrEt—F2-I
OMeF
7966PrEt—F2-OCF3H
7967PrEt—F2-OCF3SnMe3
7968PrEt—F2-OCF3Br
7969PrEt—F2-OCF3I
7970PrEt—F2-OEtFH
7971PrEt—F2-OEtFSnMe3
7972PrEt—F2-OEtFBr
7973PrEt—F2-OEtFI
7974PrEt—F2-OPrFH
7975PrEt—F2-OPrFSnMe3
7976PrEt—F2-OPrFBr
7977PrEt—F2-OPrFI
7978PrEt—F2-CF3H
7979PrEt—F2-CF3SnMe3
7980PrEt—F2-CF3Br
7981PrEt—F2-CF3I
7982PrEt—F2-Br, 6-H
CF3
7983PrEt—F2-Br, 6-SnMe3
CF3
7984PrEt—F2-Br, 6-Br
CF3
7985PrEt—F2-Br, 6-I
CF3
7986PrEt—F2-Br, 6-H
Br
7987PrEt—F2-Br, 6-SnMe3
Br
7988PrEt—F2-Br, 6-Br
Br
7989PrEt—F2-Br, 6-I
Br
7990Pr—FEtHH
7991Pr—FEtHSnMe3
7992Pr—FEtHBr
7993Pr—FEtHI
7994Pr—FEt2-FH
7995Pr—FEt2-FSnMe3
7996Pr—FEt2-FBr
7997Pr—FEt2-FI
7998Pr—FEt2-ClH
7999Pr—FEt2-ClSnMe3
8000Pr—FEt2-ClBr
8001Pr—FEt2-ClI
8002Pr—FEt2-BrH
8003Pr—FEt2-BrSnMe3
8004Pr—FEt2-BrBr
8005Pr—FEt2-BrI
8006Pr—FEt2-MeH
8007Pr—FEt2-MeSnMe3
8008Pr—FEt2-MeBr
8009Pr—FEt2-MeI
8010Pr—FEt2-EtH
8011Pr—FEt2-EtSnMe3
8012Pr—FEt2-EtBr
8013Pr—FEt2-EtI
8014Pr—FEt2-Me,H
6-Me
8015Pr—FEt2-Me,SnMe3
6-Me
8016Pr—FEt2-Me,Br
6-Me
8017Pr—FEt2-Me,I
6-Me
8018Pr—FEt2-OHH
8019Pr—FEt2-OHSnMe3
8020Pr—FEt2-OHBr
8021Pr—FEt2-OHI
8022Pr—FEt2-OMeH
8023Pr—FEt2-OMeSnMe3
8024Pr—FEt2-OMeBr
8025Pr—FEt2-OMeI
8026Pr—FEt2-H
OMeF
8027Pr—FEt2-SnMe3
OMeF
8028Pr—FEt2-Br
OMeF
8029Pr—FEt2-I
OMeF
8030Pr—FEt2-OCF3H
8031Pr—FEt2-OCF3SnMe3
8032Pr—FEt2-OCF3Br
8033Pr—FEt2-OCF3I
8034Pr—FEt2-OEtFH
8035Pr—FEt2-OEtFSnMe3
8036Pr—FEt2-OEtFBr
8037Pr—FEt2-OEtFI
8038Pr—FEt2-OPrFH
8039Pr—FEt2-OPrFSnMe3
8040Pr—FEt2-OPrFBr
8041Pr—FEt2-OPrFI
8042Pr—FEt2-CF3H
8043Pr—FEt2-CF3SnMe3
8044Pr—FEt2-CF3Br
8045Pr—FEt2-CF3I
8046Pr—FEt2-Br, 6-H
CF3
8047Pr—FEt2-Br, 6-SnMe3
CF3
8048Pr—FEt2-Br, 6-Br
CF3
8049Pr—FEt2-Br, 6-I
CF3
8050Pr—FEt2-Br, 6-H
Br
8051Pr—FEt2-Br, 6-SnMe3
Br
8052Pr—FEt2-Br, 6-Br
Br
8053Pr—FEt2-Br, 6-I
Br
8054BuEt—FHH
8055BuEt—FHSnMe3
8056BuEt—FHBr
8057BuEt—FHI
8058BuEt—F2-FH
8059BuEt—F2-FSnMe3
8060BuEt—F2-FBr
8061BuEt—F2-FI
8062BuEt—F2-ClH
8063BuEt—F2-ClSnMe3
8064BuEt—F2-ClBr
8065BuEt—F2-ClI
8066BuEt—F2-BrH
8067BuEt—F2-BrSnMe3
8068BuEt—F2-BrBr
8069BuEt—F2-BrI
8070BuEt—F2-MeH
8071BuEt—F2-MeSnMe3
8072BuEt—F2-MeBr
8073BuEt—F2-MeI
8074BuEt—F2-EtH
8075BuEt—F2-EtSnMe3
8076BuEt—F2-EtBr
8077BuEt—F2-EtI
8078BuEt—F2-Me,H
6-Me
8079BuEt—F2-Me,SnMe3
6-Me
8080BuEt—F2-Me,Br
6-Me
8081BuEt—F2-Me,I
6-Me
8082BuEt—F2-OHH
8083BuEt—F2-OHSnMe3
8084BuEt—F2-OHBr
8085BuEt—F2-OHI
8086BuEt—F2-OMeH
8087BuEt—F2-OMeSnMe3
8088BuEt—F2-OMeBr
8089BuEt—F2-OMeI
8090BuEt—F2-H
OMeF
8091BuEt—F2-SnMe3
OMeF
8092BuEt—F2-Br
OMeF
8093BuEt—F2-I
OMeF
8094BuEt—F2-OCF3H
8095BuEt—F2-OCF3SnMe3
8096BuEt—F2-OCF3Br
8097BuEt—F2-OCF3I
8098BuEt—F2-OEtFH
8099BuEt—F2-OEtFSnMe3
8100BuEt—F2-OEtFBr
8101BuEt—F2-OEtFI
8102BuEt—F2-OPrFH
8103BuEt—F2-OPrFSnMe3
8104BuEt—F2-OPrFBr
8105BuEt—F2-OPrFI
8106BuEt—F2-CF3H
8107BuEt—F2-CF3SnMe3
8108BuEt—F2-CF3Br
8109BuEt—F2-CF3I
8110BuEt—F2-Br, 6-H
CF3
8111BuEt—F2-Br, 6-SnMe3
CF3
8112BuEt—F2-Br, 6-Br
CF3
8113BuEt—F2-Br, 6-I
CF3
8114BuEt—F2-Br, 6-H
Br
8115BuEt—F2-Br, 6-SnMe3
Br
8116BuEt—F2-Br, 6-Br
Br
8117BuEt—F2-Br, 6-I
Br
8118Bu—FEtHH
8119Bu—FEtHSnMe3
8120Bu—FEtHBr
8121Bu—FEtHI
8122Bu—FEt2-FH
8123Bu—FEt2-FSnMe3
8124Bu—FEt2-FBr
8125Bu—FEt2-FI
8126Bu—FEt2-ClH
8127Bu—FEt2-ClSnMe3
8128Bu—FEt2-ClBr
8129Bu—FEt2-ClI
8130Bu—FEt2-BrH
8131Bu—FEt2-BrSnMe3
8132Bu—FEt2-BrBr
8133Bu—FEt2-BrI
8134Bu—FEt2-MeH
8135Bu—FEt2-MeSnMe3
8136Bu—FEt2-MeBr
8137Bu—FEt2-MeI
8138Bu—FEt2-EtH
8139Bu—FEt2-EtSnMe3
8140Bu—FEt2-EtBr
8141Bu—FEt2-EtI
8142Bu—FEt2-Me,H
6-Me
8143Bu—FEt2-Me,SnMe3
6-Me
8144Bu—FEt2-Me,Br
6-Me
8145Bu—FEt2-Me,I
6-Me
8146Bu—FEt2-OHH
8147Bu—FEt2-OHSnMe3
8148Bu—FEt2-OHBr
8149Bu—FEt2-OHI
8150Bu—FEt2-OMeH
8151Bu—FEt2-OMeSnMe3
8152Bu—FEt2-OMeBr
8153Bu—FEt2-OMeI
8154Bu—FEt2-H
OMeF
8155Bu—FEt2-SnMe3
OMeF
8156Bu—FEt2-Br
OMeF
8157Bu—FEt2-I
OMeF
8158Bu—FEt2-OCF3H
8159Bu—FEt2-OCF3SnMe3
8160Bu—FEt2-OCF3Br
8161Bu—FEt2-OCF3I
8162Bu—FEt2-OEtFH
8163Bu—FEt2-OEtFSnMe3
8164Bu—FEt2-OEtFBr
8165Bu—FEt2-OEtFI
8166Bu—FEt2-OPrFH
8167Bu—FEt2-OPrFSnMe3
8168Bu—FEt2-OPrFBr
8169Bu—FEt2-OPrFI
8170Bu—FEt2-CF3H
8171Bu—FEt2-CF3SnMe3
8172Bu—FEt2-CF3Br
8173Bu—FEt2-CF3I
8174Bu—FEt2-Br, 6-H
CF3
8175Bu—FEt2-Br, 6-SnMe3
CF3
8176Bu—FEt2-Br, 6-Br
CF3
8177Bu—FEt2-Br, 6-I
CF3
8178Bu—FEt2-Br, 6-H
Br
8179Bu—FEt2-Br, 6-SnMe3
Br
8180Bu—FEt2-Br, 6-Br
Br
8181Bu—FEt2-Br, 6-I
Br
8182FCH2—CH═CH—CH2MeHH
8183FCH2—CH═CH—CH2MeHSnMe3
8184FCH2—CH═CH—CH2MeHBr
8185FCH2—CH═CH—CH2MeHI
8186FCH2—CH═CH—CH2Me2-FH
8187FCH2—CH═CH—CH2Me2-FSnMe3
8188FCH2—CH═CH—CH2Me2-FBr
8189FCH2—CH═CH—CH2Me2-FI
8190FCH2—CH═CH—CH2Me2-ClH
8191FCH2—CH═CH—CH2Me2-ClSnMe3
8192FCH2—CH═CH—CH2Me2-ClBr
8193FCH2—CH═CH—CH2Me2-ClI
8194FCH2—CH═CH—CH2Me2-BrH
8195FCH2—CH═CH—CH2Me2-BrSnMe3
8196FCH2—CH═CH—CH2Me2-BrBr
8197FCH2—CH═CH—CH2Me2-BrI
8198FCH2—CH═CH—CH2Me2-MeH
8199FCH2—CH═CH—CH2Me2-MeSnMe3
8200FCH2—CH═CH—CH2Me2-MeBr
8201FCH2—CH═CH—CH2Me2-MeI
8202FCH2—CH═CH—CH2Me2-EtH
8203FCH2—CH═CH—CH2Me2-EtSnMe3
8204FCH2—CH═CH—CH2Me2-EtBr
8205FCH2—CH═CH—CH2Me2-EtI
8206FCH2—CH═CH—CH2Me2-Me,H
6-Me
8207FCH2—CH═CH—CH2Me2-Me,SnMe3
6-Me
8208FCH2—CH═CH—CH2Me2-Me,Br
6-Me
8209FCH2—CH═CH—CH2Me2-Me,I
6-Me
8210FCH2—CH═CH—CH2Me2-OHH
8211FCH2—CH═CH—CH2Me2-OHSnMe3
8212FCH2—CH═CH—CH2Me2-OHBr
8213FCH2—CH═CH—CH2Me2-OHI
8214FCH2—CH═CH—CH2Me2-OMeH
8215FCH2—CH═CH—CH2Me2-OMeSnMe3
8216FCH2—CH═CH—CH2Me2-OMeBr
8217FCH2—CH═CH—CH2Me2-OMeI
8218FCH2—CH═CH—CH2Me2-H
OMeF
8219FCH2—CH═CH—CH2Me2-SnMe3
OMeF
8220FCH2—CH═CH—CH2Me2-Br
OMeF
8221FCH2—CH═CH—CH2Me2-I
OMeF
8222FCH2—CH═CH—CH2Me2-OCF3H
8223FCH2—CH═CH—CH2Me2-OCF3SnMe3
8224FCH2—CH═CH—CH2Me2-OCF3Br
8225FCH2—CH═CH—CH2Me2-OCF3I
8226FCH2—CH═CH—CH2Me2-OEtFH
8227FCH2—CH═CH—CH2Me2-OEtFSnMe3
8228FCH2—CH═CH—CH2Me2-OEtFBr
8229FCH2—CH═CH—CH2Me2-OEtFI
8230FCH2—CH═CH—CH2Me2-OPrFH
8231FCH2—CH═CH—CH2Me2-OPrFSnMe3
8232FCH2—CH═CH—CH2Me2-OPrFBr
8233FCH2—CH═CH—CH2Me2-OPrFI
8234FCH2—CH═CH—CH2Me2-CF3H
8235FCH2—CH═CH—CH2Me2-CF3SnMe3
8236FCH2—CH═CH—CH2Me2-CF3Br
8237FCH2—CH═CH—CH2Me2-CF3I
8238FCH2—CH═CH—CH2Me2-Br, 6-H
CF3
8239FCH2—CH═CH—CH2Me2-Br, 6-SnMe3
CF3
8240FCH2—CH═CH—CH2Me2-Br, 6-Br
CF3
8241FCH2—CH═CH—CH2Me2-Br, 6-I
CF3
8242FCH2—CH═CH—CH2Me2-Br, 6-H
Br
8243FCH2—CH═CH—CH2Me2-Br, 6-SnMe3
Br
8244FCH2—CH═CH—CH2Me2-Br, 6-Br
Br
8245FCH2—CH═CH—CH2Me2-Br, 6-I
Br
8246FCH2—CH═CH—CH2EtHH
8247FCH2—CH═CH—CH2EtHSnMe3
8248FCH2—CH═CH—CH2EtHBr
8249FCH2—CH═CH—CH2EtHI
8250FCH2—CH═CH—CH2Et2-FH
8251FCH2—CH═CH—CH2Et2-FSnMe3
8252FCH2—CH═CH—CH2Et2-FBr
8253FCH2—CH═CH—CH2Et2-FI
8254FCH2—CH═CH—CH2Et2-ClH
8255FCH2—CH═CH—CH2Et2-ClSnMe3
8256FCH2—CH═CH—CH2Et2-ClBr
8257FCH2—CH═CH—CH2Et2-ClI
8258FCH2—CH═CH—CH2Et2-BrH
8259FCH2—CH═CH—CH2Et2-BrSnMe3
8260FCH2—CH═CH—CH2Et2-BrBr
8261FCH2—CH═CH—CH2Et2-BrI
8262FCH2—CH═CH—CH2Et2-MeH
8263FCH2—CH═CH—CH2Et2-MeSnMe3
8264FCH2—CH═CH—CH2Et2-MeBr
8265FCH2—CH═CH—CH2Et2-MeI
8266FCH2—CH═CH—CH2Et2-EtH
8267FCH2—CH═CH—CH2Et2-EtSnMe3
8268FCH2—CH═CH—CH2Et2-EtBr
8269FCH2—CH═CH—CH2Et2-EtI
8270FCH2—CH═CH—CH2Et2-Me,H
6-Me
8271FCH2—CH═CH—CH2Et2-Me,SnMe3
6-Me
8272FCH2—CH═CH—CH2Et2-Me,Br
6-Me
8273FCH2—CH═CH—CH2Et2-Me,I
6-Me
8274FCH2—CH═CH—CH2Et2-OHH
8275FCH2—CH═CH—CH2Et2-OHSnMe3
8276FCH2—CH═CH—CH2Et2-OHBr
8277FCH2—CH═CH—CH2Et2-OHI
8278FCH2—CH═CH—CH2Et2-OMeH
8279FCH2—CH═CH—CH2Et2-OMeSnMe3
8280FCH2—CH═CH—CH2Et2-OMeBr
8281FCH2—CH═CH—CH2Et2-OMeI
8282FCH2—CH═CH—CH2Et2-H
OMeF
8283FCH2—CH═CH—CH2Et2-SnMe3
OMeF
8284FCH2—CH═CH—CH2Et2-Br
OMeF
8285FCH2—CH═CH—CH2Et2-I
OMeF
8286FCH2—CH═CH—CH2Et2-OCF3H
8287FCH2—CH═CH—CH2Et2-OCF3SnMe3
8288FCH2—CH═CH—CH2Et2-OCF3Br
8289FCH2—CH═CH—CH2Et2-OCF3I
8290FCH2—CH═CH—CH2Et2-OEtFH
8291FCH2—CH═CH—CH2Et2-OEtFSnMe3
8292FCH2—CH═CH—CH2Et2-OEtFBr
8293FCH2—CH═CH—CH2Et2-OEtFI
8294FCH2—CH═CH—CH2Et2-OPrFH
8295FCH2—CH═CH—CH2Et2-OPrFSnMe3
8296FCH2—CH═CH—CH2Et2-OPrFBr
8297FCH2—CH═CH—CH2Et2-OPrFI
8298FCH2—CH═CH—CH2Et2-CF3H
8299FCH2—CH═CH—CH2Et2-CF3SnMe3
8300FCH2—CH═CH—CH2Et2-CF3Br
8301FCH2—CH═CH—CH2Et2-CF3I
8302FCH2—CH═CH—CH2Et2-Br, 6-H
CF3
8303FCH2—CH═CH—CH2Et2-Br, 6-SnMe3
CF3
8304FCH2—CH═CH—CH2Et2-Br, 6-Br
CF3
8305FCH2—CH═CH—CH2Et2-Br, 6-I
CF3
8306FCH2—CH═CH—CH2Et2-Br, 6-H
Br
8307FCH2—CH═CH—CH2Et2-Br, 6-SnMe3
Br
8308FCH2—CH═CH—CH2Et2-Br, 6-Br
Br
8309FCH2—CH═CH—CH2Et2-Br, 6-I
Br
8310FCH2—CH═CH—CH2Et—FHH
8311FCH2—CH═CH—CH2Et—FHSnMe3
8312FCH2—CH═CH—CH2Et—FHBr
8313FCH2—CH═CH—CH2Et—FHI
8314FCH2—CH═CH—CH2Et—F2-FH
8315FCH2—CH═CH—CH2Et—F2-FSnMe3
8316FCH2—CH═CH—CH2Et—F2-FBr
8317FCH2—CH═CH—CH2Et—F2-FI
8318FCH2—CH═CH—CH2Et—F2-ClH
8319FCH2—CH═CH—CH2Et—F2-ClSnMe3
8320FCH2—CH═CH—CH2Et—F2-ClBr
8321FCH2—CH═CH—CH2Et—F2-ClI
8322FCH2—CH═CH—CH2Et—F2-BrH
8323FCH2—CH═CH—CH2Et—F2-BrSnMe3
8324FCH2—CH═CH—CH2Et—F2-BrBr
8325FCH2—CH═CH—CH2Et—F2-BrI
8326FCH2—CH═CH—CH2Et—F2-MeH
8327FCH2—CH═CH—CH2Et—F2-MeSnMe3
8328FCH2—CH═CH—CH2Et—F2-MeBr
8329FCH2—CH═CH—CH2Et—F2-MeI
8330FCH2—CH═CH—CH2Et—F2-EtH
8331FCH2—CH═CH—CH2Et—F2-EtSnMe3
8332FCH2—CH═CH—CH2Et—F2-EtBr
8333FCH2—CH═CH—CH2Et—F2-EtI
8334FCH2—CH═CH—CH2Et—F2-Me,H
6-Me
8335FCH2—CH═CH—CH2Et—F2-Me,SnMe3
6-Me
8336FCH2—CH═CH—CH2Et—F2-Me,Br
6-Me
8337FCH2—CH═CH—CH2Et—F2-Me,I
6-Me
8338FCH2—CH═CH—CH2Et—F2-OHH
8339FCH2—CH═CH—CH2Et—F2-OHSnMe3
8340FCH2—CH═CH—CH2Et—F2-OHBr
8341FCH2—CH═CH—CH2Et—F2-OHI
8342FCH2—CH═CH—CH2Et—F2-OMeH
8343FCH2—CH═CH—CH2Et—F2-OMeSnMe3
8344FCH2—CH═CH—CH2Et—F2-OMeBr
8345FCH2—CH═CH—CH2Et—F2-OMeI
8346FCH2—CH═CH—CH2Et—F2-H
OMeF
8347FCH2—CH═CH—CH2Et—F2-SnMe3
OMeF
8348FCH2—CH═CH—CH2Et—F2-Br
OMeF
8349FCH2—CH═CH—CH2Et—F2-I
OMeF
8350FCH2—CH═CH—CH2Et—F2-OCF3H
8351FCH2—CH═CH—CH2Et—F2-OCF3SnMe3
8352FCH2—CH═CH—CH2Et—F2-OCF3Br
8353FCH2—CH═CH—CH2Et—F2-OCF3I
8354FCH2—CH═CH—CH2Et—F2-OEtFH
8355FCH2—CH═CH—CH2Et—F2-OEtFSnMe3
8356FCH2—CH═CH—CH2Et—F2-OEtFBr
8357FCH2—CH═CH—CH2Et—F2-OEtFI
8358FCH2—CH═CH—CH2Et—F2-OPrFH
8359FCH2—CH═CH—CH2Et—F2-OPrFSnMe3
8360FCH2—CH═CH—CH2Et—F2-OPrFBr
8361FCH2—CH═CH—CH2Et—F2-OPrFI
8362FCH2—CH═CH—CH2Et—F2-CF3H
8363FCH2—CH═CH—CH2Et—F2-CF3SnMe3
8364FCH2—CH═CH—CH2Et—F2-CF3Br
8365FCH2—CH═CH—CH2Et—F2-CF3I
8366FCH2—CH═CH—CH2Et—F2-Br, 6-H
CF3
8367FCH2—CH═CH—CH2Et—F2-Br, 6-SnMe3
CF3
8368FCH2—CH═CH—CH2Et—F2-Br, 6-Br
CF3
8369FCH2—CH═CH—CH2Et—F2-Br, 6-I
CF3
8370FCH2—CH═CH—CH2Et—F2-Br, 6-H
Br
8371FCH2—CH═CH—CH2Et—F2-Br, 6-SnMe3
Br
8372FCH2—CH═CH—CH2Et—F2-Br, 6-Br
Br
8373FCH2—CH═CH—CH2Et—F2-Br, 6-I
Br

TABLE 8
Substituent list for compounds of general structure XIII.
XIII
embedded image
Com-
pound
#R1 =R2 =R6 =R7 =
8374BuEtHH
8375BuEt2-Cl, 4-ClH
8376BuEt2-OMe,H
4-OMe
8377BuEt2-OHH
8378BuEt3-OHH
8379BuEt4-OHH
8380BuEt2-OMeH
8381BuEt3-OMeH
8382BuEt4-OMeH
8383BuEt2-OMeFH
8384BuEt3-OMeFH
8385BuEt4-OMeFH
8386BuEt2-OCF3H
8387BuEt3-OCF3H
8388BuEt4-OCF3H
8389BuEt2-OEtFH
8390BuEt3-OEtFH
8391BuEt4-OEtFH
8392BuEt2-OPrFH
8393BuEt3-OPrFH
8394BuEt4-OPrFH
8395BuEt2-MeH
8396BuEt3-MeH
8397BuEt4-MeH
8398BuEt2-BrH
8399BuEt3-BrH
8400BuEt4-BrH
8401BuEt2-SnMe3H
8402BuEt3-SnMe3H
8403BuEt4-SnMe3H
8404BuEtHMe
8405BuEt4-MeMe
8406BuEt4-BrMe
8407BuEt4-SnMe3Me
8408BuEt4-OHMe
8409BuEt4-OMeMe
8410BuEt4-OMeFMe
8411BuEt4-OCF3Me
8412BuEt4-OEtFMe
8413BuEt4-OPrFMe
8414PrPrHH
8415PrPr2-Cl, 4-ClH
8416PrPr2-OMe,H
4-OMe
8417PrPr2-OHH
8418PrPr3-OHH
8419PrPr4-OHH
8420PrPr2-OMeH
8421PrPr3-OMeH
8422PrPr4-OMeH
8423PrPr2-OMeFH
8424PrPr3-OMeFH
8425PrPr4-OMeFH
8426PrPr2-OCF3H
8427PrPr3-OCF3H
8428PrPr4-OCF3H
8429PrPr2-OEtFH
8430PrPr3-OEtFH
8431PrPr4-OEtFH
8432PrPr2-OPrFH
8433PrPr3-OPrFH
8434PrPr4-OPrFH
8435PrPr2-MeH
8436PrPr3-MeH
8437PrPr4-MeH
8438PrPr2-BrH
8439PrPr3-BrH
8440PrPr4-BrH
8441PrPr2-SnMe3H
8442PrPr3-SnMe3H
8443PrPr4-SnMe3H
8444PrPrHMe
8445PrPr4-MeMe
8446PrPr4-BrMe
8447PrPr4-SnMe3Me
8448PrPr4-OHMe
8449PrPr4-OMeMe
8450PrPr4-OMeFMe
8451PrPr4-OCF3Me
8452PrPr4-OEtFMe
8453PrPr4-OPrFMe
8454PrPr—FHH
8455PrPr—F2-Cl, 4-ClH
8456PrPr—F2-OMe,H
4-OMe
8457PrPr—F2-OHH
8458PrPr—F3-OHH
8459PrPr—F4-OHH
8460PrPr—F2-OMeH
8461PrPr—F3-OMeH
8462PrPr—F4-OMeH
8463PrPr—F2-OMeFH
8464PrPr—F3-OMeFH
8465PrPr—F4-OMeFH
8466PrPr—F2-OCF3H
8467PrPr—F3-OCF3H
8468PrPr—F4-OCF3H
8469PrPr—F2-OEtFH
8470PrPr—F3-OEtFH
8471PrPr—F4-OEtFH
8472PrPr—F2-OPrFH
8473PrPr—F3-OPrFH
8474PrPr—F4-OPrFH
8475PrPr—F2-MeH
8476PrPr—F3-MeH
8477PrPr—F4-MeH
8478PrPr—F2-BrH
8479PrPr—F3-BrH
8480PrPr—F4-BrH
8481PrPr—F2-SnMe3H
8482PrPr—F3-SnMe3H
8483PrPr—F4-SnMe3H
8484PrPr—FHMe
8485PrPr—F4-MeMe
8486PrPr—F4-BrMe
8487PrPr—F4-SnMe3Me
8488PrPr—F4-OHMe
8489PrPr—F4-OMeMe
8490PrPr—F4-OMeFMe
8491PrPr—F4-OCF3Me
8492PrPr—F4-OEtFMe
8493PrPr—F4-OPrFMe
8494PrEt—FHH
8495PrEt—F2-Cl, 4-ClH
8496PrEt—F2-OMe,H
4-OMe
8497PrEt—F2-OHH
8498PrEt—F3-OHH
8499PrEt—F4-OHH
8500PrEt—F2-OMeH
8501PrEt—F3-OMeH
8502PrEt—F4-OMeH
8503PrEt—F2-OMeFH
8504PrEt—F3-OMeFH
8505PrEt—F4-OMeFH
8506PrEt—F2-OCF3H
8507PrEt—F3-OCF3H
8508PrEt—F4-OCF3H
8509PrEt—F2-OEtFH
8510PrEt—F3-OEtFH
8511PrEt—F4-OEtFH
8512PrEt—F2-OPrFH
8513PrEt—F3-OPrFH
8514PrEt—F4-OPrFH
8515PrEt—F2-MeH
8516PrEt—F3-MeH
8517PrEt—F4-MeH
8518PrEt—F2-BrH
8519PrEt—F3-BrH
8520PrEt—F4-BrH
8521PrEt—F2-SnMe3H
8522PrEt—F3-SnMe3H
8523PrEt—F4-SnMe3H
8524PrEt—FHMe
8525PrEt—F4-MeMe
8526PrEt—F4-BrMe
8527PrEt—F4-SnMe3Me
8528PrEt—F4-OHMe
8529PrEt—F4-OMeMe
8530PrEt—F4-OMeFMe
8531PrEt—F4-OCF3Me
8532PrEt—F4-OEtFMe
8533PrEt—F4-OPrFMe
8534Pr—FEtHH
8535Pr—FEt2-Cl, 4-ClH
8536Pr—FEt2-OMe,H
4-OMe
8537Pr—FEt2-OHH
8538Pr—FEt3-OHH
8539Pr—FEt4-OHH
8540Pr—FEt2-OMeH
8541Pr—FEt3-OMeH
8542Pr—FEt4-OMeH
8543Pr—FEt2-OMeFH
8544Pr—FEt3-OMeFH
8545Pr—FEt4-OMeFH
8546Pr—FEt2-OCF3H
8547Pr—FEt3-OCF3H
8548Pr—FEt4-OCF3H
8549Pr—FEt2-OEtFH
8550Pr—FEt3-OEtFH
8551Pr—FEt4-OEtFH
8552Pr—FEt2-OPrFH
8553Pr—FEt3-OPrFH
8554Pr—FEt4-OPrFH
8555Pr—FEt2-MeH
8556Pr—FEt3-MeH
8557Pr—FEt4-MeH
8558Pr—FEt2-BrH
8559Pr—FEt3-BrH
8560Pr—FEt4-BrH
8561Pr—FEt2-SnMe3H
8562Pr—FEt3-SnMe3H
8563Pr—FEt4-SnMe3H
8564Pr—FEtHMe
8565Pr—FEt4-MeMe
8566Pr—FEt4-BrMe
8567Pr—FEt4-SnMe3Me
8568Pr—FEt4-OHMe
8569Pr—FEt4-OMeMe
8570Pr—FEt4-OMeFMe
8571Pr—FEt4-OCF3Me
8572Pr—FEt4-OEtFMe
8573Pr—FEt4-OPrFMe
8574BuEt—FHH
8575BuEt—F2-Cl, 4-ClH
8576BuEt—F2-OMe,H
4-OMe
8577BuEt—F2-OHH
8578BuEt—F3-OHH
8579BuEt—F4-OHH
8580BuEt—F2-OMeH
8581BuEt—F3-OMeH
8582BuEt—F4-OMeH
8583BuEt—F2-OMeFH
8584BuEt—F3-OMeFH
8585BuEt—F4-OMeFH
8586BuEt—F2-OCF3H
8587BuEt—F3-OCF3H
8588BuEt—F4-OCF3H
8589BuEt—F2-OEtFH
8590BuEt—F3-OEtFH
8591BuEt—F4-OEtFH
8592BuEt—F2-OPrFH
8593BuEt—F3-OPrFH
8594BuEt—F4-OPrFH
8595BuEt—F2-MeH
8596BuEt—F3-MeH
8597BuEt—F4-MeH
8598BuEt—F2-BrH
8599BuEt—F3-BrH
8600BuEt—F4-BrH
8601BuEt—F2-SnMe3H
8602BuEt—F3-SnMe3H
8603BuEt—F4-SnMe3H
8604BuEt—FHMe
8605BuEt—F4-MeMe
8606BuEt—F4-BrMe
8607BuEt—F4-SnMe3Me
8608BuEt—F4-OHMe
8609BeEt—F4-OMeMe
8610BuEt—F4-OMeFMe
8611BuEt—F4-OCF3Me
8612BuEt—F4-OEtFMe
8613BuEt—F4-OPrFMe
8614Bu—FEtHH
8615Bu—FEt2-Cl, 4-ClH
8616Bu—FEt2-OMe,H
4-OMe
8617Bu—FEt2-OHH
8618Bu—FEt3-OHH
8619Bu—FEt4-OHH
8620Bu—FEt2-OMeH
8621Bu—FEt3-OMeH
8622Bu—FEt4-OMeH
8623Bu—FEt2-OMeFH
8624Bu—FEt3-OMeFH
8625Bu—FEt4-OMeFH
8626Bu—FEt2-OCF3H
8627Bu—FEt3-OCF3H
8628Bu—FEt4-OCF3H
8629Bu—FEt2-OEtFH
8630Bu—FEt3-OEtFH
8631Bu—FEt4-OEtFH
8632Bu—FEt2-OPrFH
8633Bu—FEt3-OPrFH
8634Bu—FEt4-OPrFH
8635Bu—FEt2-MeH
8636Bu—FEt3-MeH
8637Bu—FEt4-MeH
8638Bu—FEt2-BrH
8639Bu—FEt3-BrH
8640Bu—FEt4-BrH
8641Bu—FEt2-SnMe3H
8642Bu—FEt3-SnMe3H
8643Bu—FEt4-SnMe3H
8644Bu—FEtHMe
8645Bu—FEt4-MeMe
8646Bu—FEt4-BrMe
8647Bu—FEt4-SnMe3Me
8648Bu—FEt4-OHMe
8649Bu—FEt4-OMeMe
8650Bu—FEt4-OMeFMe
8651Bu—FEt4-OCF3Me
8652Bu—FEt4-OEtFMe
8653Bu—FEt4-OPrFMe
8654FCH2—CH═CH—CH2MeHH
8655FCH2—CH═CH—CH2Me2-Cl, 4-ClH
8656FCH2—CH═CH—CH2Me2-OMe,H
4-OMe
8657FCH2—CH═CH—CH2Me2-OHH
8658FCH2—CH═CH—CH2Me3-OHH
8659FCH2—CH═CH—CH2Me4-OHH
8660FCH2—CH═CH—CH2Me2-OMeH
8661FCH2—CH═CH—CH2Me3-OMeH
8662FCH2—CH═CH—CH2Me4-OMeH
8663FCH2—CH═CH—CH2Me2-OMeFH
8664FCH2—CH═CH—CH2Me3-OMeFH
8665FCH2—CH═CH—CH2Me4-OMeFH
8666FCH2—CH═CH—CH2Me2-OCF3H
8667FCH2—CH═CH—CH2Me3-OCF3H
8668FCH2—CH═CH—CH2Me4-OCF3H
8669FCH2—CH═CH—CH2Me2-OEtFH
8670FCH2—CH═CH—CH2Me3-OEtFH
8671FCH2—CH═CH—CH2Me4-OEtFH
8672FCH2—CH═CH—CH2Me2-OPrFH
8673FCH2—CH═CH—CH2Me3-OPrFH
8674FCH2—CH═CH—CH2Me4-OPrFH
8675FCH2—CH═CH—CH2Me2-MeH
8676FCH2—CH═CH—CH2Me3-MeH
8677FCH2—CH═CH—CH2Me4-MeH
8678FCH2—CH—CH—CH2Me2-BrH
8679FCH2—CH═CH—CH2Me3-BrH
8680FCH2—CH═CH—CH2Me4-BrH
8681FCH2—CH═CH—CH2Me2-SnMe3H
8682FCH2—CH═CH—CH2Me3-SnMe3H
8683FCH2—CH═CH—CH2Me4-SnMe3H
8684FCH2—CH═CH—CH2MeHMe
8685FCH2—CH═CH—CH2Me4-MeMe
8686FCH2—CH═CH—CH2Me4-BrMe
8687FCH2—CH═CH—CH2Me4-SnMe3Me
8688FCH2—CH═CH—CH2Me4-OHMe
8689FCH2—CH═CH—CH2Me4-OMeMe
8690FCH2—CH═CH—CH2Me4-OMeFMe
8691FCH2—CH═CH—CH2Me4-OCF3Me
8692FCH2—CH═CH—CH2Me4-OEtFMe
8693FCH2—CH═CH—CH2Me4-OPrFMe
8694FCH2—CH═CH—CH2EtHH
8695FCH2—CH═CH—CH2Et2-Cl, 4-ClH
8696FCH2—CH═CH—CH2Et2-OMe,H
4-OMe
8697FCH2—CH═CH—CH2Et2-OHH
8698FCH2—CH═CH—CH2Et3-OHH
8699FCH2—CH═CH—CH2Et4-OHH
8700FCH2—CH═CH—CH2Et2-OMeH
8701FCH2—CH═CH—CH2Et3-OMeH
8702FCH2—CH═CH—CH2Et4-OMeH
8703FCH2—CH═CH—CH2Et2-OMeFH
8704FCH2—CH═CH—CH2Et3-OMeFH
8705FCH2—CH═CH—CH2Et4-OMeFH
8706FCH2—CH═CH—CH2Et2-OCF3H
8707FCH2—CH═CH—CH2Et3-OCF3H
8708FCH2—CH═CH—CH2Et4-OCF3H
8709FCH2—CH═CH—CH2Et2-OEtFH
8710FCH2—CH═CH—CH2Et3-OEtFH
8711FCH2—CH═CH—CH2Et4-OEtFH
8712FCH2—CH═CH—CH2Et2-OPrFH
8713FCH2—CH═CH—CH2Et3-OPrFH
8714FCH2—CH═CH—CH2Et4-OPrFH
8715FCH2—CH═CH—CH2Et2-MeH
8716FCH2—CH═CH—CH2Et3-MeH
8717FCH2—CH═CH—CH2Et4-MeH
8718FCH2—CH═CH—CH2Et2-BrH
8719FCH2—CH═CH—CH2Et3-BrH
8720FCH2—CH═CH—CH2Et4-BrH
8721FCH2—CH═CH—CH2Et2-SnMe3H
8722FCH2—CH═CH—CH2Et3-SnMe3H
8723FCH2—CH═CH—CH2Et4-SnMe3H
8724FCH2—CH═CH—CH2EtHMe
8725FCH2—CH═CH—CH2Et4-MeMe
8726FCH2—CH═CH—CH2Et4-BrMe
8727FCH2—CH═CH—CH2Et4-SnMe3Me
8728FCH2—CH═CH—CH2Et4-OHMe
8729FCH2—CH═CH—CH2Et4-OMeMe
8730FCH2—CH═CH—CH2Et4-OMeFMe
8731FCH2—CH═CH—CH2Et4-OCF3Me
8732FCH2—CH═CH—CH2Et4-OEtFMe
8733FCH2—CH═CH—CH2Et4-OPrFMe
8734FCH2—CH═CH—CH2Et—FHH
8735FCH2—CH═CH—CH2Et—F2-Cl, 4-ClH
8736FCH2—CH═CH—CH2Et—F2-OMe,H
4-OMe
8737FCH2—CH═CH—CH2Et—F2-OHH
8738FCH2—CH═CH—CH2Et—F3-OHH
8739FCH2—CH═CH—CH2Et—F4-OHH
8740FCH2—CH═CH—CH2Et—F2-OMeH
8741FCH2—CH═CH—CH2Et—F3-OMeH
8742FCH2—CH═CH—CH2Et—F4-OMeH
8743FCH2—CH═CH—CH2Et—F2-OMeFH
8744FCH2—CH═CH—CH2Et—F3-OMeFH
8745FCH2—CH═CH—CH2Et—F4-OMeFH
8746FCH2—CH═CH—CH2Et—F2-OCF3H
8747FCH2—CH═CH—CH2Et—F3-OCF3H
8748FCH2—CH═CH—CH2Et—F4-OCF3H
8749FCH2—CH═CH—CH2Et—F2-OEtFH
8750FCH2—CH═CH—CH2Et—F3-OEtFH
8751FCH2—CH═CH—CH2Et—F4-OEtFH
8752FCH2—CH═CH—CH2Et—F2-OPrFH
8753FCH2—CH═CH—CH2Et—F3-OPrFH
8754FCH2—CH═CH—CH2Et—F4-OPrFH
8755FCH2—CH═CH—CH2Et—F2-MeH
8756FCH2—CH═CH—CH2Et—F3-MeH
8757FCH2—CH═CH—CH2Et—F4-MeH
8758FCH2—CH═CH—CH2Et—F2-BrH
8759FCH2—CH═CH—CH2Et—F3-BrH
8760FCH2—CH═CH—CH2Et—F4-BrH
8761FCH2—CH═CH—CH2Et—F2-SnMe3H
8762FCH2—CH═CH—CH2Et—F3-SnMe3H
8763FCH2—CH═CH—CH2Et—F4-SnMe3H
8764FCH2—CH═CH—CH2Et—FHMe
8765FCH2—CH═CH—CH2Et—F4-MeMe
8766FCH2—CH═CH—CH2Et—F4-BrMe
8767FCH2—CH═CH—CH2Et—F4-SnMe3Me
8768FCH2—CH═CH—CH2Et—F4-OHMe
8769FCH2—CH═CH—CH2Et—F4-OMeMe
8770FCH2—CH═CH—CH2Et—F4-OMeFMe
8771FCH2—CH═CH—CH2Et—F4-OCF3Me
8772FCH2—CH═CH—CH2Et—F4-OEtFMe
8773FCH2—CH═CH—CH2Et—F4-OPrFMe

TABLE 9
Substituent list for compounds of general structure XIV.
XIV
embedded image
Com-
pound
#R8 =R3 =n =
8774BuH1
8775Bu2-t-Bu1
8776Bu2-Br1
8777Bu3-Br1
8778Bu4-Br1
8779Bu2-I1
8780Bu3-I1
8781Bu4-I1
8782Bu2-SnMe31
8783Bu3-SnMe31
8784Bu4-SnMe31
8785Bu2-Me1
8786Bu3-Me1
8787Bu4-Me1
8788Bu2-OH1
8789Bu3-OH1
8790Bu4-OH1
8791Bu2-OMe1
8792Bu3-OMe1
8793Bu4-OMe1
8794Bu2-OMeF1
8795Bu3-OMeF1
8796Bu4-OMeF1
8797Bu2-OCF31
8798Bu3-OCF31
8799Bu4-OCF31
8800Bu2-OEtF1
8801Bu3-OEtF1
8802Bu4-OEtF1
8803Bu2-OPrF1
8804Bu3-OPrF1
8805Bu4-OPrF1
8806Bu2-SH1
8807Bu3-SH1
8808Bu4-SH1
8809Bu2-SMe1
8810Bu3-SMe1
8811Bu4-SMe1
8812Bu2-SMeF1
8813Bu3-SMeF1
8814Bu4-SMeF1
8815Bu2-SCF31
8816Bu3-SCF31
8817Bu4-SCF31
8818Bu2-SEtF1
8819Bu3-SEtF1
8820Bu4-SEtF1
8821Bu2-SPrF1
8822Bu3-SPrF1
8823Bu4-SPrF1
8824Bu2-OMe, 4-OMe1
8825Bu2-Me, 5-OH1
8826Bu2-Me, 5-OMe1
8827Bu2-Me, 5-OMeF1
8828Bu2-Me, 5-OEtF1
8829Bu2-Me, 5-OPrF1
8830Bu2-Me, 4-OH1
8831Bu2-Me, 4-OMe1
8832Bu2-Me, 4-OMeF1
8833Bu2-Me, 4-OCF31
8834Bu2-Me, 4-OEtF1
8835Bu2-Me, 4-OPrF1
8836Bu2-OH, 4-Me1
8837Bu2-OMe, 4-Me1
8838Bu2-OMeF, 4-Me1
8839Bu2-OCF3, 4-Me1
8840Bu2-OEtF, 4-Me1
8841Bu2-OPrF, 4-Me1
8842Bu2-Cl, 4-OH1
8843Bu2-Cl, 4-OMe1
8844Bu2-Cl, 4-OMeF1
8845Bu2-Cl, 4-OCF31
8846Bu2-Cl, 4-OEtF1
8847Bu2-Cl, 4-OPrF1
8848Bu2-F, 4-F1
8849Bu2-Cl, 4-Cl1
8850Bu2-Cl, 4-F1
8851Bu2-Cl, 4-NO21
8852Bu2-Cl, 4-NH21
8853Bu2-Cl, 4-NHMe1
8854Bu2-Cl, 4-NMe21
8855Bu2-Cl, 4-NMe3OTf1
8856Bu2-Cl, 4-NMe3I1
8857Bu2-Cl, 5-F1
8858Bu2-Cl, 5-NO21
8859Bu2-Cl, 5-NH21
8860Bu2-Cl, 5-NHMe1
8861Bu2-Cl, 5-NMe21
8862Bu2-Cl, 5-NMe3OTf1
8863Bu2-Cl, 5-NMe3I1
8864Bu2-F, 4-Cl1
8865Bu2-NO2, 4-Cl1
8866Bu2-NH2, 4-Cl1
8867Bu2-NHMe, 4-Cl1
8868Bu2-NMe2, 4-Cl1
8869Bu2-NMe3OTf, 4-Cl1
8870Bu2-NMe3I, 4-Cl1
8871Bu2-F, 5-Cl1
8872Bu2-NO2, 5-Cl1
8873Bu2-NH2, 5-Cl1
8874Bu2-NHMe, 5-Cl1
8875Bu2-NMe2, 5-Cl1
8876Bu2-NMe3OTf, 5-Cl1
8877Bu2-NMe3I, 5-Cl1
8878Bu2-Br, 4-F1
8879Bu2-Br, 4-NO21
8880Bu2-Br, 4-NH21
8881Bu2-Br, 4-NHMe1
8882Bu2-Br, 4-NMe21
8883Bu2-Br, 4-NMe3OTf1
8884Bu2-Br, 4-NMe3I1
8885Bu2-Br, 5-F1
8886Bu2-Br, 5-NO21
8887Bu2-Br, 5-NH21
8888Bu2-Br, 5-NHMe1
8889Bu2-Br, 5-NMe21
8890Bu2-Br, 5-NMe3OTf1
8891Bu2-Br, 5-NMe3I1
8892Bu2-F, 4-Br1
8893Bu2-NO2, 4-Br1
8894Bu2-NH2, 4-Br1
8895Bu2-NHMe, 4-Br1
8896Bu2-NMe2, 4-Br1
8897Bu2-NMe3OTf, 4-Br1
8898Bu2-NMe3I, 4-Br1
8899Bu2-I, 4-F1
8900Bu2-I, 4-NO21
8901Bu2-I, 4-NH21
8902Bu2-I, 4-NHMe1
8903Bu2-I, 4-NMe21
8904Bu2-I, 4-NMe3OTf1
8905Bu2-I, 4-NMe3I1
8906Bu2-F, 4-I1
8907Bu2-NO2, 4-I1
8908Bu2-NH2, 4-I1
8909Bu2-NHMe, 4-I1
8910Bu2-NMe2, 4-I1
8911Bu2-NMe3OTf, 4-I1
8912Bu2-NMe3I, 4-I1
8913Bu2-Me, 3-F1
8914Bu2-Me, 3-NO21
8915Bu2-Me, 3-NH21
8916Bu2-Me, 3-NHMe1
8917Bu2-Me, 3-NMe21
8918Bu2-Me, 3-NMe3OTf1
8919Bu2-Me, 3-NMe3I1
8920Bu2-Me, 4-F1
8921Bu2-Me, 4-NO21
8922Bu2-Me, 4-NH21
8923Bu2-Me, 4-NHMe1
8924Bu2-Me, 4-NMe21
8925Bu2-Me, 4-NMe3OTf1
8926Bu2-Me, 4-NMe3I1
8927Bu2-Me, 5-F1
8928Bu2-Me, 5-NO21
8929Bu2-Me, 5-NH21
8930Bu2-Me, 5-NHMe1
8931Bu2-Me, 5-NMe21
8932Bu2-Me, 5-NMe3OTf1
8933Bu2-Me, 5-NMe3I1
8934Bu2-F, 4-Me1
8935Bu2-NO2, 4-Me1
8936Bu2-NH2, 4-Me1
8937Bu2-NHMe, 4-Me1
8938Bu2-NMe2, 4-Me1
8939Bu2-NMe3, 4-Me1
8940Bu2-NMe3OTf, 4-Me1
8941Bu2-NMe3I, 4-Me1
8942Bu2-SnMe3, 4-F1
8943Bu2-SnMe3, 5-F1
8944Bu2-F, 4-SnMe31
8945Bu2-Br, 6-Cl, 4-F1
8946Bu2-Br, 6-Cl, 4-NO21
8947Bu2-Br, 6-Cl, 4-NH21
8948Bu2-Br, 6-Cl, 4-1
NHMe
8949Bu2-Br, 6-Cl, 4-NMe21
8950Bu2-Br, 6-Cl, 4-1
NMe3OTf
8951Bu2-Br, 6-Cl, 4-1
NMe3I
8952Bu2-Me, 6-Cl, 4-F1
8953Bu2-SnMe3, 6-Cl, 4-F1
8954Bu2-Cl, 4-Me1
8955Bu2-Cl, 4-Br1
8956Bu2-Cl, 4-SnMe31
8957Bu2-Br, 4-Cl1
8958Bu2-SnMe3, 4-Cl1
8959Bu2-Me, 4-Cl1
8960Bu2-Br, 4-Br1
8961Bu2-Br, 4-Me1
8962Bu2-Br, 4-SnMe31
8963Bu2-SnMe3, 4-Br1
8964Bu2-Me, 4-Br1
8965Bu2-Me, 4-SnMe31
8966Bu2-SnMe3, 4-Me1
8967Bu2-Me, 4-Me1
8968Bu2-Et, 4-Br1
8969Bu2-Et, 4-SnMe31
8970Bu2-Et, 4-Me1
8971Bu2-Me, 4-Me, 6-Me1
8972Bu2-Me, 4-Br, 6-Me1
8973Bu2-Me, 4-SnMe3, 6-1
Me
8974Bu2-Et, 6-Me1
8975Bu2-Br, 4-i-Pr1
8976Bu2-SnMe3, 4-i-Pr1
8977Bu2-Me, 4-i-Pr1
8978Bu2-Br, 4-Br, 6-Br1
8979Bu2-Br, 4-Me, 6-Br1
8980Bu2-Br, 4-SnMe3, 6-1
Br
8981Bu2-SnMe3, 4-Br, 6-1
Br
8982Bu2-Br, 4-Br, 6-Me1
8983Bu2-Br, 4-CF3, 6-Br1
8984Bu2-Br, 4-Br, 6-CF31
8985Bu2-CF3, 4-CF31
8986Bu2-Cl, 4-CF31
8987Bu2-CF3, 4-Cl1
8988Bu2-Br, 4-CF31
8989Bu2-SnMe3, 4-CF31
8990Bu2-Me, 4-CF31
8991Bu2-CF3, 4-Br1
8992Bu2-CF3, 4-SnMe31
8993Bu2-CF3, 4-Me1
8994Bu2-Br, 4-OH1
8995Bu2-Br, 4-OMe1
8996Bu2-Br, 4-OMeF1
8997Bu2-Br, 4-OCF31
8998Bu2-Br, 4-OEtF1
8999Bu2-Br, 4-OPrF1
9000Bu2-OH, 4-Br1
9001Bu2-OMe, 4-Br1
9002Bu2-OMeF, 4-Br1
9003Bu2-OCF3, 4-Br1
9004Bu2-OEtF, 4-Br1
9005Bu2-OPrF, 4-Br1
9006Bu2-I, 4-OH1
9007Bu2-I, 4-OMe1
9008Bu2-I, 4-OMeF1
9009Bu2-I, 4-OCF31
9010Bu2-I, 4-OEtF1
9011Bu2-I, 4-OPrF1
9012Bu2-OH, 4-I1
9013Bu2-OMe, 4-I1
9014Bu2-OMeF, 4-I1
9015Bu2-OCF3, 4-I1
9016Bu2-OEtF, 4-I1
9017Bu2-OPrF, 4-I1
9018Bu2-SnMe3, 4-OH1
9019Bu2-SnMe3, 4-OMe1
9020Bu2-SnMe3, 4-OMeF1
9021Bu2-SnMe3, 4-OCF31
9022Bu2-SnMe3, 4-OEtF1
9023Bu2-SnMe3, 4-OPrF1
9024Bu2-OH, 4-SnMe31
9025Bu2-OMe, 4-SnMe31
9026Bu2-OMeF, 4-SnMe31
9027Bu2-OCF3, 4-SnMe31
9028Bu2-OEtF, 4-SnMe31
9029Bu2-OPrF, 4-SnMe31
9030BuH2
9031Bu2-t-Bu2
9032Bu2-Br2
9033Bu3-Br2
9034Bu4-Br2
9035Bu2-I2
9036Bu3-I2
9037Bu4-I2
9038Bu2-SnMe32
9039Bu3-SnMe32
9040Bu4-SnMe32
9041Bu2-Me2
9042Bu3-Me2
9043Bu4-Me2
9044Bu2-OH2
9045Bu3-OH2
9046Bu4-OH2
9047Bu2-OMe2
9048Bu3-OMe2
9049Bu4-OMe2
9050Bu2-OMeF2
9051Bu3-OMeF2
9052Bu4-OMeF2
9053Bu2-OCF32
9054Bu3-OCF32
9055Bu4-OCF32
9056Bu2-OEtF2
9057Bu3-OEtF2
9058Bu4-OEtF2
9059Bu2-OPrF2
9060Bu3-OPrF2
9061Bu4-OPrF2
9062Bu2-SH2
9063Bu3-SH2
9064Bu4-SH2
9065Bu2-SMe2
9066Bu3-SMe2
9067Bu4-SMe2
9068Bu2-SMeF2
9069Bu3-SMeF2
9070Bu4-SMeF2
9071Bu2-SCF32
9072Bu3-SCF32
9073Bu4-SCF32
9074Bu2-SEtF2
9075Bu3-SEtF2
9076Bu4-SEtF2
9077Bu2-SPrF2
9078Bu3-SPrF2
9079Bu4-SPrF2
9080Bu2-OMe, 4-OMe2
9081Bu2-Me, 5-OH2
9082Bu2-Me, 5-OMe2
9083Bu2-Me, 5-OMeF2
9084Bu2-Me, 5-OEtF2
9085Bu2-Me, 5-OPrF2
9086Bu2-Me, 4-OH2
9087Bu2-Me, 4-OMeF2
9088Bu2-Me, 4-OCF32
9089Bu2-Me, 4-OEtF2
9090Bu2-Me, 4-OPrF2
9091Bu2-OH, 4-Me2
9092Bu2-OMe, 4-Me2
9093Bu2-OMeF, 4-Me2
9094Bu2-OCF3, 4-Me2
9095Bu2-OEtF, 4-Me2
9096Bu2-OPrF, 4-Me2
9097Bu2-Cl, 4-OH2
9098Bu2-Cl, 4-OMeF2
9099Bu2-Cl, 4-OCF32
9100Bu2-Cl, 4-OEtF2
9101Bu2-Cl, 4-OPrF2
9102Bu2-F, 4-F2
9103Bu2-Cl, 4-F2
9104Bu2-Cl, 4-NO22
9105Bu2-Cl, 4-NH22
9106Bu2-Cl, 4-NHMe2
9107Bu2-Cl, 4-NMe22
9108Bu2-Cl, 4-NMe3OTf2
9109Bu2-Cl, 4-NMe3I2
9110Bu2-Cl, 5-F2
9111Bu2-Cl, 5-NO22
9112Bu2-Cl, 5-NH22
9113Bu2-Cl, 5-NHMe2
9114Bu2-Cl, 5-NMe22
9115Bu2-Cl, 5-NMe3OTf2
9116Bu2-Cl, 5-NMe3I2
9117Bu2-F, 4-Cl2
9118Bu2-NO2, 4-Cl2
9119Bu2-NH2, 4-Cl2
9120Bu2-NHMe, 4-Cl2
9121Bu2-NMe2, 4-Cl2
9122Bu2-NMe3OTf, 4-Cl2
9123Bu2-NMe3I, 4-Cl2
9124Bu2-F, 5-Cl2
9125Bu2-NO2, 5-Cl2
9126Bu2-NH2, 5-Cl2
9127Bu2-NHMe, 5-Cl2
9128Bu2-NMe2, 5-Cl2
9129Bu2-NMe3OTf, 5-Cl2
9130Bu2-NMe3I, 5-Cl2
9131Bu2-Br, 4-F2
9132Bu2-Br, 4-NO22
9133Bu2-Br, 4-NH22
9134Bu2-Br, 4-NHMe2
9135Bu2-Br, 4-NMe22
9136Bu2-Br, 4-NMe3OTf2
9137Bu2-Br, 4-NMe3I2
9138Bu2-Br, 5-F2
9139Bu2-Br, 5-NO22
9140Bu2-Br, 5-NH22
9141Bu2-Br, 5-NHMe2
9142Bu2-Br, 5-NMe22
9143Bu2-Br, 5-NMe3OTf2
9144Bu2-Br, 5-NMe3I2
9145Bu2-F, 4-Br2
9146Bu2-NO2, 4-Br2
9147Bu2-NH2, 4-Br2
9148Bu2-NHMe, 4-Br2
9149Bu2-NMe2, 4-Br2
9150Bu2-NMe3OTf, 4-Br2
9151Bu2-NMe3I, 4-Br2
9152Bu2-I, 4-F2
9153Bu2-I, 4-NO22
9154Bu2-I, 4-NH22
9155Bu2-I, 4-NHMe2
9156Bu2-I, 4-NMe22
9157Bu2-I, 4-NMe3OTf2
9158Bu2-I, 4-NMe3I2
9159Bu2-F, 4-I2
9160Bu2-NO2, 4-I2
9161Bu2-NH2, 4-I2
9162Bu2-NHMe, 4-I2
9163Bu2-NMe2, 4-I2
9164Bu2-NMe3OTf, 4-I2
9165Bu2-NMe3I, 4-I2
9166Bu2-Me, 3-F2
9167Bu2-Me, 3-NO22
9168Bu2-Me, 3-NH22
9169Bu2-Me, 3-NHMe2
9170Bu2-Me, 3-NMe22
9171Bu2-Me, 3-NMe3OTf2
9172Bu2-Me, 3-NMe3I2
9173Bu2-Me, 4-F2
9174Bu2-Me, 4-NO22
9175Bu2-Me, 4-NH22
9176Bu2-Me, 4-NHMe2
9177Bu2-Me, 4-NMe22
9178Bu2-Me, 4-NMe3OTf2
9179Bu2-Me, 4-NMe3I2
9180Bu2-Me, 5-F2
9181Bu2-Me, 5-NO22
9182Bu2-Me, 5-NH22
9183Bu2-Me, 5-NHMe2
9184Bu2-Me, 5-NMe22
9185Bu2-Me, 5-NMe3OTf2
9186Bu2-Me, 5-NMe3I2
9187Bu2-F, 4-Me2
9188Bu2-NO2, 4-Me2
9189Bu2-NH2, 4-Me2
9190Bu2-NHMe, 4-Me2
9191Bu2-NMe2, 4-Me2
9192Bu2-NMe3, 4-Me2
9193Bu2-NMe3OTf, 4-Me2
9194Bu2-NMe3I, 4-Me2
9195Bu2-SnMe3, 4-F2
9196Bu2-SnMe3, 5-F2
9197Bu2-F, 4-SnMe32
9198Bu2-Br, 6-Cl, 4-F2
9199Bu2-Br, 6-Cl, 4-NO22
9200Bu2-Br, 6-Cl, 4-NH22
9201Bu2-Br, 6-Cl, 4-2
NHMe
9202Bu2-Br, 6-Cl, 4-NMe22
9203Bu2-Br, 6-Cl, 4-2
NMe3OTf
9204Bu2-Br, 6-Cl, 4-2
NMe3I
9205Bu2-Me, 6-Cl, 4-F2
9206Bu2-SnMe3, 6-Cl, 4-F2
9207Bu2-Cl, 4-Me2
9208Bu2-Cl, 4-Br2
9209Bu2-Cl, 4-SnMe32
9210Bu2-Br, 4-Cl2
9211Bu2-SnMe3, 4-Cl2
9212Bu2-Me, 4-Cl2
9213Bu2-Br, 4-Br2
9214Bu2-Br, 4-Me2
9215Bu2-Br, 4-SnMe32
9216Bu2-SnMe3, 4-Br2
9217Bu2-Me, 4-Br2
9218Bu2-Me, 4-SnMe32
9219Bu2-SnMe3, 4-Me2
9220Bu2-Me, 4-Me2
9221Bu2-Et, 4-Br2
9222Bu2-Et, 4-SnMe32
9223Bu2-Et, 4-Me2
9224Bu2-Me, 4-Br, 6-Me2
9225Bu2-Me, 4-SnMe3, 6-2
Me
9226Bu2-Et, 6-Me2
9227Bu2-SnMe3, 4-i-Pr2
9228Bu2-Me, 4-i-Pr2
9229Bu2-Br, 4-Br, 6-Br2
9230Bu2-Br, 4-Me, 6-Br2
9231Bu2-Br, 4-SnMe3, 6-2
Br
9232Bu2-SnMe3, 4-Br, 6-2
Br
9233Bu2-Br, 4-Br, 6-Me2
9234Bu2-Br, 4-CF3, 6-Br2
9235Bu2-Br, 4-Br, 6-CF32
9236Bu2-CF3, 4-CF32
9237Bu2-Cl, 4-CF32
9238Bu2-CF3, 4-Cl2
9239Bu2-Br, 4-CF32
9240Bu2-SnMe3, 4-CF32
9241Bu2-Me, 4-CF32
9242Bu2-CF3, 4-Br2
9243Bu2-CF3, 4-SnMe32
9244Bu2-CF3, 4-Me2
9245Bu2-Br, 4-OH2
9246Bu2-Br, 4-OMe2
9247Bu2-Br, 4-OMeF2
9248Bu2-Br, 4-OCF32
9249Bu2-Br, 4-OEtF2
9250Bu2-Br, 4-OPrF2
9251Bu2-OH, 4-Br2
9252Bu2-OMe, 4-Br2
9253Bu2-OMeF, 4-Br2
9254Bu2-OCF3, 4-Br2
9255Bu2-OEtF, 4-Br2
9256Bu2-OPrF, 4-Br2
9257Bu2-I, 4-OH2
9258Bu2-I, 4-OMe2
9259Bu2-I, 4-OMeF2
9260Bu2-I, 4-OCF32
9261Bu2-I, 4-OEtF2
9262Bu2-I, 4-OPrF2
9263Bu2-OH, 4-I2
9264Bu2-OMe, 4-I2
9265Bu2-OMeF, 4-I2
9266Bu2-OCF3, 4-I2
9267Bu2-OEtF, 4-I2
9268Bu2-OPrF, 4-I2
9269Bu2-SnMe3, 4-OH2
9270Bu2-SnMe3, 4-OMe2
9271Bu2-SnMe3, 4-OMeF2
9272Bu2-SnMe3, 4-OCF32
9273Bu2-SnMe3, 4-OEtF2
9274Bu2-SnMe3, 4-OPrF2
9275Bu2-OH, 4-SnMe32
9276Bu2-OMe, 4-SnMe32
9277Bu2-OMeF, 4-SnMe32
9278Bu2-OCF3, 4-SnMe32
9279Bu2-OEtF, 4-SnMe32
9280Bu2-OPrF, 4-SnMe32
9281Bu—FH1
9282Bu—F2-t-Bu1
9283Bu—F2-Br1
9284Bu—F3-Br1
9285Bu—F4-Br1
9286Bu—F2-I1
9287Bu—F3-I1
9288Bu—F4-I1
9289Bu—F2-SnMe31
9290Bu—F3-SnMe31
9291Bu—F4-SnMe31
9292Bu—F2-Me1
9293Bu—F3-Me1
9294Bu—F4-Me1
9295Bu—F2-OH1
9296Bu—F3-OH1
9297Bu—F4-OH1
9298Bu—F2-OMe1
9299Bu—F3-OMe1
9300Bu—F4-OMe1
9301Bu—F2-OMeF1
9302Bu—F3-OMeF1
9303Bu—F4-OMeF1
9304Bu—F2-OCF31
9305Bu—F3-OCF31
9306Bu—F4-OCF31
9307Bu—F2-OEtF1
9308Bu—F3-OEtF1
9309Bu—F4-OEtF1
9310Bu—F2-OPrF1
9311Bu—F3-OPrF1
9312Bu—F4-OPrF1
9313Bu—F2-SH1
9314Bu—F3-SH1
9315Bu—F4-SH1
9316Bu—F2-SMe1
9317Bu—F3-SMe1
9318Bu—F4-SMe1
9319Bu—F2-SMeF1
9320Bu—F3-SMeF1
9321Bu—F4-SMeF1
9322Bu—F2-SCF31
9323Bu—F3-SCF31
9324Bu—F4-SCF31
9325Bu—F2-SEtF1
9326Bu—F3-SEtF1
9327Bu—F4-SEtF1
9328Bu—F2-SPrF1
9329Bu—F3-SPrF1
9330Bu—F4-SPrF1
9331Bu—F2-OMe, 4-OMe1
9332Bu—F2-Me, 5-OH1
9333Bu—F2-Me, 5-OMe1
9334Bu—F2-Me, 5-OMeF1
9335Bu—F2-Me, 5-OEtF1
9336Bu—F2-Me, 5-OPrF1
9337Bu—F2-Me, 4-OH1
9338Bu—F2-Me, 4-OMe1
9339Bu—F2-Me, 4-OMeF1
9340Bu—F2-Me, 4-OCF31
9341Bu—F2-Me, 4-OEtF1
9342Bu—F2-Me, 4-OPrF1
9343Bu—F2-OH, 4-Me1
9344Bu—F2-OMe, 4-Me1
9345Bu—F2-OMeF, 4-Me1
9346Bu—F2-OCF3, 4-Me1
9347Bu—F2-OEtF, 4-Me1
9348Bu—F2-OPrF, 4-Me1
9349Bu—F2-Cl, 4-OH1
9350Bu—F2-Cl, 4-OMe1
9351Bu—F2-Cl, 4-OMeF1
9352Bu—F2-Cl, 4-OCF31
9353Bu—F2-Cl, 4-OEtF1
9354Bu—F2-Cl, 4-OPrF1
9355Bu—F2-F, 4-F1
9356Bu—F2-Cl, 4-Cl1
9357Bu—F2-Cl, 4-F1
9358Bu—F2-Cl, 4-NO21
9359Bu—F2-Cl, 4-NH21
9360Bu—F2-Cl, 4-NHMe1
9361Bu—F2-Cl, 4-NMe21
9362Bu—F2-Cl, 4-NMe3OTf1
9363Bu—F2-Cl, 4-NMe3I1
9364Bu—F2-Cl, 5-F1
9365Bu—F2-Cl, 5-NO21
9366Bu—F2-Cl, 5-NH21
9367Bu—F2-Cl, 5-NHMe1
9368Bu—F2-Cl, 5-NMe21
9369Bu—F2-Cl, 5-NMe3OTf1
9370Bu—F2-Cl, 5-NMe3I1
9371Bu—F2-F, 4-Cl1
9372Bu—F2-NO2, 4-Cl1
9373Bu—F2-NH2, 4-Cl1
9374Bu—F2-NHMe, 4-Cl1
9375Bu—F2-NMe2, 4-Cl1
9376Bu—F2-NMe3OTf, 4-Cl1
9377Bu—F2-NMe3I, 4-Cl1
9378Bu—F2-F, 5-Cl1
9379Bu—F2-NO2, 5-Cl1
9380Bu—F2-NH2, 5-Cl1
9381Bu—F2-NHMe, 5-Cl1
9382Bu—F2-NMe2, 5-Cl1
9383Bu—F2-NMe3OTf, 5-Cl1
9384Bu—F2-NMe3I, 5-Cl1
9385Bu—F2-Br, 4-F1
9386Bu—F2-Br, 4-NO21
9387Bu—F2-Br, 4-NH21
9388Bu—F2-Br, 4-NHMe1
9389Bu—F2-Br, 4-NMe21
9390Bu—F2-Br, 4-NMe3OTf1
9391Bu—F2-Br, 4-NMe3I1
9392Bu—F2-Br, 5-F1
9393Bu—F2-Br, 5-NO21
9394Bu—F2-Br, 5-NH21
9395Bu—F2-Br, 5-NHMe1
9396Bu—F2-Br, 5-NMe21
9397Bu—F2-Br, 5-NMe3OTf1
9398Bu—F2-Br, 5-NMe3I1
9399Bu—F2-F, 4-Br1
9400Bu—F2-NO2, 4-Br1
9401Bu—F2-NH2, 4-Br1
9402Bu—F2-NHMe, 4-Br1
9403Bu—F2-NMe2, 4-Br1
9404Bu—F2-NMe3OTf, 4-Br1
9405Bu—F2-NMe3I, 4-Br1
9406Bu—F2-I, 4-F1
9407Bu—F2-I, 4-NO21
9408Bu—F2-I, 4-NH21
9409Bu—F2-I, 4-NHMe1
9410Bu—F2-I, 4-NMe21
9411Bu—F2-I, 4-NMe3OTf1
9412Bu—F2-I, 4-NMe3I1
9413Bu—F2-F, 4-I1
9414Bu—F2-NO2, 4-I1
9415Bu—F2-NH2, 4-I1
9416Bu—F2-NHMe, 4-I1
9417Bu—F2-NMe2, 4-I1
9418Bu—F2-NMe3OTf, 4-I1
9419Bu—F2-NMe3I, 4-I1
9420Bu—F2-Me, 3-F1
9421Bu—F2-Me, 3-NO21
9422Bu—F2-Me, 3-NH21
9423Bu—F2-Me, 3-NHMe1
9424Bu—F2-Me, 3-NMe21
9425Bu—F2-Me, 3-NMe3OTf1
9426Bu—F2-Me, 3-NMe3I1
9427Bu—F2-Me, 4-F1
9428Bu—F2-Me, 4-NO21
9429Bu—F2-Me, 4-NH21
9430Bu—F2-Me, 4-NHMe1
9431Bu—F2-Me, 4-NMe21
9432Bu—F2-Me, 4-NMe3OTf1
9433Bu—F2-Me, 4-NMe3I1
9434Bu—F2-Me, 5-F1
9435Bu—F2-Me, 5-NO21
9436Bu—F2-Me, 5-NH21
9437Bu—F2-Me, 5-NHMe1
9438Bu—F2-Me, 5-NMe21
9439Bu—F2-Me, 5-NMe3OTf1
9440Bu—F2-Me, 5-NMe3I1
9441Bu—F2-F, 4-Me1
9442Bu—F2-NO2, 4-Me1
9443Bu—F2-NH2, 4-Me1
9444Bu—F2-NHMe, 4-Me1
9445Bu—F2-NMe2, 4-Me1
9446Bu—F2-NMe3, 4-Me1
9447Bu—F2-NMe3OTf, 4-Me1
9448Bu—F2-NMe3I, 4-Me1
9449Bu—F2-SnMe3, 4-F1
9450Bu—F2-SnMe3, 5-F1
9451Bu—F2-F, 4-SnMe31
9452Bu—F2-Br, 6-Cl, 4-F1
9453Bu—F2-Br, 6-Cl, 4-NO21
9454Bu—F2-Br, 6-Cl, 4-NH21
9455Bu—F2-Br, 6-Cl, 4-1
NHMe
9456Bu—F2-Br, 6-Cl, 4-NMe21
9457Bu—F2-Br, 6-Cl, 4-1
NMe3OTf
9458Bu—F2-Br, 6-Cl, 4-1
NMe3I
9459Bu—F2-Me, 6-Cl, 4-F1
9460Bu—F2-SnMe3, 6-Cl, 4-F1
9461Bu—F2-Cl, 4-Me1
9462Bu—F2-Cl, 4-Br1
9463Bu—F2-Cl, 4-SnMe31
9464Bu—F2-Br, 4-Cl1
9465Bu—F2-SnMe3, 4-Cl1
9466Bu—F2-Me, 4-Cl1
9467Bu—F2-Br, 4-Br1
9468Bu—F2-Br, 4-Me1
9469Bu—F2-Br, 4-SnMe31
9470Bu—F2-SnMe3, 4-Br1
9471Bu—F2-Me, 4-Br1
9472Bu—F2-Me, 4-SnMe31
9473Bu—F2-SnMe3, 4-Me1
9474Bu—F2-Me, 4-Me1
9475Bu—F2-Et, 4-Br1
9476Bu—F2-Et, 4-SnMe31
9477Bu—F2-Et, 4-Me1
9478Bu—F2-Me, 4-Me, 6-Me1
9479Bu—F2-Me, 4-Br, 6-Me1
9480Bu—F2-Me, 4-SnMe3, 6-1
Me
9481Bu—F2-Et, 6-Me1
9482Bu—F2-Br, 4-i-Pr1
9483Bu—F2-SnMe3, 4-i-Pr1
9484Bu—F2-Me, 4-i-Pr1
9485Bu—F2-Br, 4-Br, 6-Br1
9486Bu—F2-Br, 4-Me, 6-Br1
9487Bu—F2-Br, 4-SnMe3, 6-1
Br
9488Bu—F2-SnMe3, 4-Br, 6-1
Br
9489Bu—F2-Br, 4-Br, 6-Me1
9490Bu—F2-Br, 4-CF3, 6-Br1
9491Bu—F2-Br, 4-Br, 6-CF31
9492Bu—F2-CF3, 4-CF31
9493Bu—F2-Cl, 4-CF31
9494Bu—F2-CF3, 4-Cl1
9495Bu—F2-Br, 4-CF31
9496Bu—F2-SnMe3, 4-CF31
9497Bu—F2-Me, 4-CF31
9498Bu—F2-CF3, 4-Br1
9499Bu—F2-CF3, 4-SnMe31
9500Bu—F2-CF3, 4-Me1
9501Bu—F2-Br, 4-OH1
9502Bu—F2-Br, 4-OMe1
9503Bu—F2-Br, 4-OMeF1
9504Bu—F2-Br, 4-OCF31
9505Bu—F2-Br, 4-OEtF1
9506Bu—F2-Br, 4-OPrF1
9507Bu—F2-OH, 4-Br1
9508Bu—F2-OMe, 4-Br1
9509Bu—F2-OMeF, 4-Br1
9510Bu—F2-OCF3, 4-Br1
9511Bu—F2-OEtF, 4-Br1
9512Bu—F2-OPrF, 4-Br1
9513Bu—F2-I, 4-OH1
9514Bu—F2-I, 4-OMe1
9515Bu—F2-I, 4-OMeF1
9516Bu—F2-I, 4-OCF31
9517Bu—F2-I, 4-OEtF1
9518Bu—F2 I, 4-OPrF1
9519Bu—F2-OH, 4-I1
9520Bu—F2-OMe, 4-I1
9521Bu—F2-OMeF, 4-I1
9522Bu—F2-OCF3, 4-I1
9523Bu—F2-OEtF, 4-I1
9524Bu—F2-OPrF, 4-I1
9525Bu—F2-SnMe3, 4-OH1
9526Bu—F2-SnMe3, 4-OMe1
9527Bu—F2-SnMe3, 4-OMeF1
9528Bu—F2-SnMe3, 4-OCF31
9529Bu—F2-SnMe3, 4-OEtF1
9530Bu—F2-SnMe3, 4-OPrF1
9531Bu—F2-OH, 4-SnMe31
9532Bu—F2-OMe, 4-SnMe31
9533Bu—F2-OMeF, 4-SnMe31
9534Bu—F2-OCF3, 4-SnMe31
9535Bu—F2-OEtF, 4-SnMe31
9536Bu—F2-OPrF, 4-SnMe31
9537Bu—FH2
9538Bu—F2-t-Bu2
9539Bu—F2-Br2
9540Bu—F3-Br2
9541Bu—F4-Br2
9542Bu—F2-I2
9543Bu—F3-I2
9544Bu—F4-I2
9545Bu—F2-SnMe32
9546Bu—F3-SnMe32
9547Bu—F4-SnMe32
9548Bu—F2-Me2
9549Bu—F3-Me2
9550Bu—F4-Me2
9551Bu—F2-OH2
9552Bu—F3-OH2
9553Bu—F4-OH2
9554Bu—F2-OMe2
9555Bu—F3-OMe2
9556Bu—F4-OMe2
9557Bu—F2-OMeF2
9558Bu—F3-OMeF2
9559Bu—F4-OMeF2
9560Bu—F2-OCF32
9561Bu—F3-OCF32
9562Bu—F4-OCF32
9563Bu—F2-OEtF2
9564Bu—F3-OEtF2
9565Bu—F4-OEtF2
9566Bu—F2-OPrF2
9567Bu—F3-OPrF2
9568Bu—F4-OPrF2
9569Bu—F2-SH2
9570Bu—F3-SH2
9571Bu—F4-SH2
9572Bu—F2-SMe2
9573Bu—F3-SMe2
9574Bu—F4-SMe2
9575Bu—F2-SMeF2
9576Bu—F3-SMeF2
9577Bu—F4-SMeF2
9578Bu—F2-SCF32
9579Bu—F3-SCF32
9580Bu—F4-SCF32
9581Bu—F2-SEtF2
9582Bu—F3-SEtF2
9583Bu—F4-SEtF2
9584Bu—F2-SPrF2
9585Bu—F3-SPrF2
9586Bu—F4-SPrF2
9587Bu—F2-OMe, 4-OMe2
9588Bu—F2-Me, 5-OH2
9589Bu—F2-Me, 5-OMe2
9590Bu—F2-Me, 5-OMeF2
9591Bu—F2-Me, 5-OEtF2
9592Bu—F2-Me, 5-OPrF2
9593Bu—F2-Me, 4-OH2
9594Bu—F2-Me, 4-OMe2
9595Bu—F2-Me, 4-OMeF2
9596Bu—F2-Me, 4-OCF32
9597Bu—F2-Me, 4-OEtF2
9598Bu—F2-Me, 4-OPrF2
9599Bu—F2-OH, 4-Me2
9600Bu—F2-OMe, 4-Me2
9601Bu—F2-OMeF, 4-Me2
9602Bu—F2-OCF3, 4-Me2
9603Bu—F2-OEtF, 4-Me2
9604Bu—F2-OPrF, 4-Me2
9605Bu—F2-Cl, 4-OH2
9606Bu—F2-Cl, 4-OMe2
9607Bu—F2-Cl, 4-OMeF2
9608Bu—F2-Cl, 4-OCF32
9609Bu—F2-Cl, 4-OEtF2
9610Bu—F2-Cl, 4-OPrF2
9611Bu—F2-F, 4-F2
9612Bu—F2-Cl, 4-Cl2
9613Bu—F2-Cl, 4-F2
9614Bu—F2-Cl, 4-NO22
9615Bu—F2-Cl, 4-NH22
9616Bu—F2-Cl, 4-NHMe2
9617Bu—F2-Cl, 4-NMe22
9618Bu—F2-Cl, 4-NMe3OTf2
9619Bu—F2-Cl, 4-NMe3I2
9620Bu—F2-Cl, 5-F2
9621Bu—F2-Cl, 5-NO22
9622Bu—F2-Cl, 5-NH22
9623Bu—F2-Cl, 5-NHMe2
9624Bu—F2-Cl, 5-NMe22
9625Bu—F2-Cl, 5-NMe3OTf2
9626Bu—F2-Cl, 5-NMe3I2
9627Bu—F2-F, 4-Cl2
9628Bu—F2-NO2, 4-Cl2
9629Bu—F2-NH2, 4-Cl2
9630Bu—F2-NHMe, 4-Cl2
9631Bu—F2-NMe2, 4-Cl2
9632Bu—F2-NMe3OTf, 4-Cl2
9633Bu—F2-NMe3I, 4-Cl2
9634Bu—F2-F, 5-Cl2
9635Bu—F2-NO2, 5-Cl2
9636Bu—F2-NH2, 5-Cl2
9637Bu—F2-NHMe, 5-Cl2
9638Bu—F2-NMe2, 5-Cl2
9639Bu—F2-NMe3OTf, 5-Cl2
9640Bu—F2-NMe3I, 5-Cl2
9641Bu—F2-Br, 4-F2
9642Bu—F2-Br, 4-NO22
9643Bu—F2-Br, 4-NH22
9644Bu—F2-Br, 4-NHMe2
9645Bu—F2-Br, 4-NMe22
9646Bu—F2-Br, 4-NMe3OTf2
9647Bu—F2-Br, 4-NMe3I2
9648Bu—F2-Br, 5-F2
9649Bu—F2-Br, 5-NO22
9650Bu—F2-Br, 5-NH22
9651Bu—F2-Br, 5-NHMe2
9652Bu—F2-Br, 5-NMe22
9653Bu—F2-Br, 5-NMe3OTf2
9654Bu—F2-Br, 5-NMe3I2
9655Bu—F2-F, 4-Br2
9656Bu—F2-NO2, 4-Br2
9657Bu—F2-NH2, 4-Br2
9658Bu—F2-NHMe, 4-Br2
9659Bu—F2-NMe2, 4-Br2
9660Bu—F2-NMe3OTf, 4-Br2
9661Bu—F2-NMe3I, 4-Br2
9662Bu—F2-I, 4-F2
9663Bu—F2-I, 4-NO22
9664Bu—F2-I, 4-NH22
9665Bu—F2-I, 4-NHMe2
9666Bu—F2-I, 4-NMe22
9667Bu—F2-I, 4-NMe3OTf2
9668Bu—F2-I, 4-NMe3I2
9669Bu—F2-F, 4-I2
9670Bu—F2-NO2, 4-I2
9671Bu—F2-NH2, 4-I2
9672Bu—F2-NHMe, 4-I2
9673Bu—F2-NMe2, 4-I2
9674Bu—F2-NMe3OTf, 4-I2
9675Bu—F2-NMe3I, 4-I2
9676Bu—F2-Me, 3-F2
9677Bu—F2-Me, 3-NO22
9678Bu—F2-Me, 3-NH22
9679Bu—F2-Me, 3-NHMe2
9680Bu—F2-Me, 3-NMe22
9681Bu—F2-Me, 3-NMe3OTf2
9682Bu—F2-Me, 3-NMe3I2
9683Bu—F2-Me, 4-F2
9684Bu—F2-Me, 4-NO22
9685Bu—F2-Me, 4-NH22
9686Bu—F2-Me, 4-NHMe2
9687Bu—F2-Me, 4-NMe22
9688Bu—F2-Me, 4-NMe3OTf2
9689Bu—F2-Me, 4-NMe3I2
9690Bu—F2-Me, 5-F2
9691Bu—F2-Me, 5-NO22
9692Bu—F2-Me, 5-NH22
9693Bu—F2-Me, 5-NHMe2
9694Bu—F2-Me, 5-NMe22
9695Bu—F2-Me, 5-NMe3OTf2
9696Bu—F2-Me, 5-NMe3I2
9697Bu—F2-F, 4-Me2
9698Bu—F2-NO2, 4-Me2
9699Bu—F2-NH2, 4-Me2
9700Bu—F2-NHMe, 4-Me2
9701Bu—F2-NMe2, 4-Me2
9702Bu—F2-NMe3, 4-Me2
9703Bu—F2-NMe3OTf, 4-Me2
9704Bu—F2-NMe3I, 4-Me2
9705Bu—F2-SnMe3, 4-F2
9706Bu—F2-SnMe3, 5-F2
9707Bu—F2-F, 4-SnMe32
9708Bu—F2-Br, 6-Cl, 4-F2
9709Bu—F2-Br, 6-Cl, 4-NO22
9710Bu—F2-Br, 6-Cl, 4-NH22
9711Bu—F2-Br, 6-Cl, 4-2
NHMe
9712Bu—F2-Br, 6-Cl, 4-NMe22
9713Bu—F2-Br, 6-Cl, 4-2
NMe3OTf
9714Bu—F2-Br, 6-Cl, 4-2
NMe3I
9715Bu—F2-Me, 6-Cl, 4-F2
9716Bu—F2-SnMe3, 6-Cl, 4-F2
9717Bu—F2-Cl, 4-Me2
9718Bu—F2-Cl, 4-Br2
9719Bu—F2-Cl, 4-SnMe32
9720Bu—F2-Br, 4-Cl2
9721Bu—F2-SnMe3, 4-Cl2
9722Bu—F2-Me, 4-Cl2
9723Bu—F2-Br, 4-Br2
9724Bu—F2-Br, 4-Me2
9725Bu—F2-Br, 4-SnMe32
9726Bu—F2-SnMe3, 4-Br2
9727Bu—F2-Me, 4-Br2
9728Bu—F2-Me, 4-SnMe32
9729Bu—F2-SnMe3, 4-Me2
9730Bu—F2-Me, 4-Me2
9731Bu—F2-Et, 4-Br2
9732Bu—F2-Et, 4-SnMe32
9733Bu—F2-Et, 4-Me2
9734Bu—F2-Me, 4-Me, 6-Me2
9735Bu—F2-Me, 4-Br, 6-Me2
9736Bu—F2-Me, 4-SnMe3, 6-2
Me
9737Bu—F2-Et, 6-Me2
9738Bu—F2-Br, 4-i-Pr2
9739Bu—F2-SnMe3, 4-i-Pr2
9740Bu—F2-Me, 4-i-Pr2
9741Bu—F2-Br, 4-Br, 6-Br2
9742Bu—F2-Br, 4-Me, 6-Br2
9743Bu—F2-Br, 4-SnMe3, 6-2
Br
9744Bu—F2-SnMe3, 4-Br, 6-2
Br
9745Bu—F2-Br, 4-Br, 6-Me2
9746Bu—F2-Br, 4-CF3, 6-Br2
9747Bu—F2-Br, 4-Br, 6-CF32
9748Bu—F2-CF3, 4-CF32
9749Bu—F2-Cl, 4-CF32
9750Bu—F2-CF3, 4-Cl2
9751Bu—F2-Br, 4-CF32
9752Bu—F2-SnMe3, 4-CF32
9753Bu—F2-Me, 4-CF32
9754Bu—F2-CF3, 4-Br2
9755Bu—F2-CF3, 4-SnMe32
9756Bu—F2-CF3, 4-Me2
9757Bu—F2-Br, 4-OH2
9758Bu—F2-Br, 4-OMe2
9759Bu—F2-Br, 4-OMeF2
9760Bu—F2-Br, 4-OCF32
9761Bu—F2-Br, 4-OEtF2
9762Bu—F2-Br, 4-OPrF2
9763Bu—F2-OH, 4-Br2
9764Bu—F2-OMe, 4-Br2
9765Bu—F</