Match Document Document Title
10783627 Predicting cancer recurrence using local co-occurrence of cell morphology (LoCoM)  
Embodiments include apparatus for predicting cancer recurrence based on local co-occurrence of cell morphology (LoCoM). The apparatus includes image acquisition circuitry that identifies and...
10782302 Detectors of serum biomarkers for predicting ovarian cancer recurrence  
Polypeptide marker antigens for detecting the presence of autoantibody biomarkers associated with ovarian cancer recurrence, each of the polypeptide marker antigens binding specifically to at...
10782301 Biomarkers for pancreatic cancer  
The present invention relates to pancreatic cancers and the use of biomarkers in biological samples for the diagnosis of such conditions, in particular pancreatic ductal adenocarcinoma. The...
10782296 Antibody that specifically recognizes and binds to REIC/Dkk-3 protein having active structure and monitoring of cancer treatment using such anti-REIC/Dkk-3 antibody  
This invention provides an anti-REIC antibody that specifically recognizes a cancer-associated protein (REIC/Dkk-3) and enables monitoring of cancer treatment effects involving the use of the...
10781471 NRAS related cancer therapy  
The present invention encompasses the recognition that identification of alternative means to block RAS oncogenic signaling may be required for developing novel cancer therapies. Among other...
10781446 RNA nanoparticle for treatment of gastric cancer  
The presently-disclosed subject matter relates to RNA-based composition and method to treat gastric cancer in a subject. More particularly, the presently disclosed subject matter relates to a RNA...
10781265 Humanized antibodies against Globo H and uses thereof in cancer treatments  
A humanized anti-Globo H antibody, or an scFv or Fab fragment thereof, comprising a heavy-chain variable domain having three complementary regions consisting of HCDR1, HCDR2, and HCDR3 and a...
10781244 Peptides and combination of peptides for use in immunotherapy against ovarian cancer and other cancers  
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The...
10781243 Combined T cell receptor gene therapy of cancer against MHC I and MHC II-restricted epitopes of the tumor antigen NY-ESO-1  
The present invention relates to the field of immunotherapy, in particular adoptive T cell therapy or T cell receptor (TCR) gene therapy of cancer. The invention provides a nucleic acid encoding...
10781226 Photoactivatable cancer prodrug  
Described herein is photocaging methodology using ruthenium (II) complexes with 7-deazahypoxanthine-based anticancer agents. Specifically, 7-deazahypoxanthines are converted into photoactivatable...
10780182 Methods and compositions for treating metastatic breast cancer and other cancers in the brain  
A composition comprising at least one AAV vector formulated for central nervous system delivery is described. The composition comprises at least one expression cassette which contains sequences...
10780179 Conjugates for the treatment of cancer targeted at intracellular tumor-associated antigens  
The present disclosure relates to conjugates, preferably, antibody-drug conjugates, directed against select non-transmembrane tumor antigens that are normally intracellular but can be secreted...
10780152 Use of toll-like receptor agonist for treating cancer  
The present invention is directed to methods and agents used for treating cancer in Toll-Like Receptor 5-expressing tissues by providing a Toll-Like Receptor agonist such as flagellin. The present...
10780117 Macrophages eat cancer cells using their own calreticulin as a guide  
Therapeutic and diagnostic methods are provided, which methods relate to the induction of expression of calreticulin on phagocytic cells. Specifically, the methods relate to macrophage-mediated...
10780084 Antibody-recruiting molecules for the treatment of cancer  
The present invention relates to chimeric (including bifunctional) compounds, compositions comprising those compounds and methods of treating cancer in a patient or subject, especially including...
10780076 Inhibition of cancer cell motility  
Provided herein are compositions and methods for inhibiting cancer cell motility and/or metastasis. In particular embodiments, KBU2046 (or an analog thereof) and one or more additional therapies...
10779785 Semantic segmentation for cancer detection in digital breast tomosynthesis  
A method, apparatus and non-transitory computer readable medium are for segmenting different types of structures, including cancerous lesions and regular structures like vessels and skin, in a...
10776607 Predicting prostate cancer biochemical recurrence and metastasis with computer extracted features from tumor nuclei and benign regions  
Embodiments predict biochemical recurrence (BCR) or metastasis by accessing a set of images of a region of tissue demonstrating cancerous pathology, including a tumor region and a tumor adjacent...
10775336 Electromechanical approach for cancer detection  
An electrical probe is disclosed for measuring an electrical response from a biological cell. The electrical probe includes a tungsten microwire having a sharpened tip section, a catalyst layer...
10774387 Methods for identifying androgen receptor splice variants in subjects having castration resistant prostate cancer  
Methods of the present disclosure provide for detection of mutations and splice variants of the androgen receptor using a non-invasive approach, RNAseq, for examining circulating tumor cells.
10774386 Serum or plasma microRNA as biomarkers for non-small cell lung cancer  
Provided are non-small cell lung cancer markers and the use thereof in diagnosing and monitoring diseases in vitro. The non-small cell lung cancer markers include at least one of 26 selected...
10774309 Natural killer cell immunotherapy for treating cancer  
The invention provides a chimeric receptor comprising NKG2D, DAP10 and CD3 zeta. Also disclosed is a composition comprising this chimeric receptor and methods for making and using it to enhance...
10774130 Method of treating cancer by administering multivalent fibronectin based scaffold domain proteins  
The present invention relates to multivalent polypeptides comprising at least two fibronectin scaffold domains connected via a polypeptide linker. The invention also relates to multivalent...
10774047 Dimeric quinacrine derivatives as autophagy inhibitors for cancer therapy  
The invention provides dimeric quinacrine derivatives and related compounds and compositions, methods of treatment and syntheses. The novel compounds exhibit unexpected anticancer activity and are...
10774046 Inhibitors for the treatment of cancer and related methods  
Some embodiments of the invention include inventive compounds. Other embodiments include compositions (e.g., pharmaceutical compositions) comprising the inventive compound. Still other embodiments...
10773095 Direct magnetic imaging with metamaterial for focusing and thermal ablation using SPION nanoparticles for cancer diagnosis and treatment  
Devices and methods for identifying and destroying cancer cells are disclosed. Devices and methods may relate to techniques of imaging and/or irradiating cells bearing a plurality of...
10772944 Bacterial ghosts for the treatment of cancer  
The present invention relates to a composition comprising Bacterial Ghosts, optionally an active agent, and a pharmaceutically acceptable carrier and/or excipient for use in the treatment of cancer.
10772918 Probiotic prevention and treatment of colon cancer  
Methods are provided herein for preventing, delaying the onset of or reducing the progression of colorectal tumorigenesis in a subject identified as at risk of colorectal tumorigenesis, comprising...
10772907 Immune modulation with TLR9 agonists for cancer treatment  
The present invention relates to methods for treating a tumor, including a metastatic tumor, with TLR9 agonist in combination with an immune checkpoint inhibitor therapy.
10772903 Targeting fungi in combination with cancer therapy  
Described herein are methods for the treatment of cancer by modulating fungal populations to enhance the therapeutic response to a cancer therapy. In particular, the present invention discloses...
10772898 Combination therapies and methods of use thereof for treating cancer  
Pharmaceutical compositions including an effective amount of an antiandrogen or androgen antagonist in combination with a Plk inhibitor and methods of use thereof for treating cancer are...
10772878 Demethylpenclomedine analogs and their use as anti-cancer agents  
This disclosure concerns novel demethylpenclomedine analogs. Also disclosed are pharmaceutical compositions and methods for using such compositions to treat hyperproliferative disorders. In one...
10772872 Antimitotic amides for the treatment of cancer and proliferative disorders  
Novel, antimitotic heteroaryl amides and pharmaceutically acceptable salts of Formula I where Ar, R5, R6, R8, R9, R11, X1, and X2 are as defined herein, as compounds for treatment and prevention...
10772671 System and method for treating cancer through DNA damage with cold atmospheric plasma with self-organized patterns  
Cold atmospheric plasma is an emerging technology in the treatment of cancer. Meanwhile, different types of self-organized pattern (SOP) phenomenon have been reported in a wide of range of...
10772670 Systems and methods for treating prostate cancer  
A vapor delivery needle and method is provided that is adapted for treating prostate cancer. The energy delivery probe can apply condensable vapor energy to tissue, such as a peripheral zone...
10772318 Methods and reagents for maintaining the visability of cancer cells in surgically removed tissue  
A composition and method for generating reagents and the composition of these reagents for the stabilization and preservation of viability of cancer tissue which has been surgically excised and...
10769790 Methods of cancer detection  
The present invention provides, among other things, methods of identifying cancerous or pre-cancerous tissue including providing a first region of tissue from a subject, calculating a roughness...
10769783 Predicting prostate cancer biochemical recurrence using combined nuclear NF-KB/P65 localization and gland morphology  
Embodiments include controlling a processor to perform operations for predicting biochemical recurrence (BCR) in prostate cancer (PCa), including accessing a first digitized pathology slide having...
10768179 Method for predicting responsiveness to cancer treatment using p300-inhibiting compound  
It has been found that CBP and p300 are in the relationship of synthetic lethality, and treatment inhibiting p300 is a promising approach for the treatment of CBP-mutated cancer. It has also been...
10768167 Plasma membrane citrate transporter for use in the diagnosis and treatment of cancer  
The present invention is directed to a method for the diagnosis of cancer involving the plasma membrane citrate transporter (pmCiC). The invention is further directed to a modified substrate or...
10767231 Method for detecting lung cancer using lung cancer-specific methylation marker gene  
The present invention relates to a method for detecting lung cancer using a lung cancer-specific biomarker, and more particularly to a biomarker for lung cancer diagnosis, which can detect...
10767230 MicroRNA biomarker for the diagnosis and treatment of gastric cancer  
Disclosed are methods of determining the likelihood of a subject having or developing a gastric cancer. The methods comprise measuring the expression level of at least one miRNA having at least...
10767183 Combination vectors and methods for treating cancer  
A composition for treating cancer is disclosed. The composition includes a lentiviral particle and an aminobisphosphonate drug. The lentiviral particle is capable of infecting a target cell, such...
10767182 Direct and selective inhibition of MDM4 for treatment of cancer  
The present application relates to the field of cancer, particularly that of cancers with high MDM4 protein levels (such as melanoma, breast, colon or lung cancers, glioblastoma, retinoblastoma,...
10767178 Compositions and methods of using piRNAS in cancer diagnostics and therapeutics  
Aberrantly expressed piRNAs, genetically associated piRNAs and their relationship with cancer risk and severity are provided. Compositions and methods of using piRNA for treating cancer are...
10766968 Methods and compositions relating to anti-CHI3L1 antibody reagents to treat cancer  
It is demonstrated herein that inhibitors of immune checkpoints and CHI3L1 are synergistic. Accordingly, described herein are methods and compositions relating to combinatorial therapies for...
10766962 FZD7 specific antibodies and vaccines to treat cancer and control stem cell function  
The present invention is directed to antibodies and fragments thereof having binding specificity for FZD7, which preferably do not substantially interact with (bind to) other FZD family members,...
10766943 Universal chimeric antigen expressing immune cells for targeting of diverse multiple antigens and method of manufacturing the same and use of the same for treatment of cancer, infections and autoimmune disorders  
The present invention relates to immune cell-based anti-cancer therapeutics and methods of using the therapeutics in the treatment of cancer.
10766937 Compositions and methods of treating cancer  
The present invention provides compositions and methods of treating various disorders associated with aberrant cell growth.
10766926 Composition for autophagy inhibiting in cell, and pharmaceutical composition for preventing or treating tumor disease, or inhibiting anti-cancer agents resistance containing the same  
Provided are a polypeptide having the activity of inhibiting autophagy in a cell, a composition for inhibiting autophagy in a cell, and particularly in a tumor cell, containing the polypeptide as...