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10682388 Targeting of PELP1 in cancer therapy  
The disclosure describes PELP1 binding peptides and peptoids and their use the interaction of PELP1 with molecules that lead to oncogenic signaling in cancers.
10682356 Combination therapies for treatment of cancer  
Combination therapies for treatment of cancer are provided. The disclosed methods comprise administration of a cyclin-dependent kinase inhibitor and a DNA methyltransferase inhibitor to a mammal...
10682353 Varlitinib for use in the treatment of resistant or refractory cancer  
The present disclosure provides a method of treating a patient with refractory or resistant cancer by administering a therapeutically effective amount of a compound of formula (I), such as...
10682348 Molecules for administration to ROS1 mutant cancer cells  
Substituted indazole derivatives of formula (I) or formula 2.(I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical...
10682339 Pharmaceutical compositions directly targeting FKBP52 for the treatment of prostate cancer and methods of using same  
Embodiments of the current invention include methods and compositions for regulating the activity of hormone receptors.
10679752 System and method for computing survivorship risk associated with delaying therapy in breast cancer  
An estimate is made of a time since a given presenting cancer would have first been detectable using a known diagnostic technique, and an estimate is also made of initial characteristics of the...
10679730 Prognostic and predictive breast cancer signature  
Embodiments of the invention are directed to methods of determining the prognosis of a breast cancer patient by evaluating a specified set of genes. Specifically, methods may comprise calculating...
10677801 Diagnosis and treatment of breast cancer  
The present invention relates to compositions and methods for-determining a treatment course of action. In particular, the present invention relates to compositions and methods for the prediction...
10677800 Biomarkers for diagnosis and prognosis of lung cancer  
Provided herein are methods for non-invasively diagnosing and/or prognosing a lung cancer and for determining the efficacy of a therapeutic treatment regimen for the lung cancer. Expression levels...
10676792 Prognostic and diagnostic methods for colorectal cancer  
Provided herein are methods for selecting a drug therapy for a patient with cancer, such as colorectal cancer, pancreatic cancer, lung cancer or breast cancer. The method includes determining or...
10676531 Anti-CD43 antibody and use thereof for cancer treatment  
Provided is an antibody for treating a cancer, more specifically, an anti-CD43 antibody binding to an extracellular domain of CD43, compositions for treating a cancer or inhibiting a cancer stem...
10676487 Synthesis and composition of photodynamic therapeutic agents for the targeted treatment of cancer  
The present invention describes new compounds that are useful for image-guided surgery and photodynamic therapy. In particular the compounds may be targeted to the nucleus or the mitochondria...
10676480 Anti-cancer compounds targeting Ral GTPases and methods of using the same  
Methods of inhibiting the growth or metastasis of a cancer in a subject by inhibiting a Ral GTPase in the subject, and small molecule inhibitors of Ral GTPases useful in the methods of the...
10675338 Peptides and combination of peptides for use in immunotherapy against breast cancer and other cancers  
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The...
10675337 Cancer vaccine for cats  
The present invention provides a nucleic acid, or an immunogenic composition thereof, that comprises a sequence encoding a cat telomerase deprived of telomerase catalytic activity, or a fragment...
10675326 Compositions comprising cupredoxins for treating cancer  
The present invention discloses methods and materials for killing and/or inhibiting the growth of a cancer cell via preferential entry of a cytotoxic compound. Preferential entry of the cytotoxic...
10675304 Combination immunotherapies for treatment of cancer  
Described herein are compositions and methods for treating a disease, particularly a cancer, with an immune checkpoint modulatory agent and a strain of an Arbovirus or a strain of an Alphavirus....
10675303 Extracellular matrix compositions for the treatment of cancer  
The present invention is directed to methods of inhibiting cancer cell growth or proliferation by contacting the cancer cell with an extracellular matrix (ECM) composition. Also provided are...
10675289 Methods of treating pancreatic cancer  
Described herein are methods and compositions for the treatment of pancreatic cancer in a subject in need thereof. The pancreatic cancer may be resistant to other therapeutic regimens. The methods...
10675262 Development of dietary therapy in cancer  
The invention provides new compositions or combinations thereof for the treatment of cancer. More specifically, the invention provides compositions or combinations thereof for cancer treatment...
10675257 Method of treating cancer with a combination of benzylideneguanidine derivatives and chemotherapeutic agent  
The present invention relates to a composition for use in treating a glioma or ameliorating the effects of a glioma, particularly glioblastoma, wherein said composition comprises a first active...
10671885 Cancer diagnostic method and system  
A method and system for classifying tissue suspected of being abnormal as being malignant or benign. The method includes generating a set of selection features, performing statistical applications...
10670603 Diagnosis and treatment of cancer expressing ILT3 or ILT3 ligand  
The present invention relates to methods of using the expression of ILTL3 ligand or ILT3 on certain types of cancer cells as a diagnostic tool. Methods are provided for treating ILT3-ligand...
10669589 Method to determine responsiveness of cancer to epidermal growth factor receptor targeting treatments  
Disclosed herein are methods and reagents for determining the responsiveness of cancer to an epidermal growth factor receptor (EGFR) targeting treatment. The detection of these mutations will...
10669588 Methods for sub-typing and treating cancer  
This invention relates to a novel approach for the identification and stratification of subtypes of cancer, particularly pancreatic ductal adenocarcinoma (PDAC). The invention furthermore relates...
10669584 Cancer antigen-specific T-cell receptor gene, peptide encoded by the gene, and use of them  
Disclosed are: a nucleotide sequence and an amino acid sequence for CDR3 region of T-cell receptor (TCR) gene of WT1-specific cytotoxic T-cell (CTL) for WT1 protein; a method for the detection or...
10669536 Diagnosis of prostate cancer  
The invention provides methods for isolating RNA from whole urine and urine fractions for the diagnosis of prostate cancer and/or benign prostate hyperplasia. An exemplary method for diagnosing...
10669349 Compositions and methods for treatment of cancer  
Compositions, e.g., compositions comprising cellular therapeutics and/or protein therapeutics, and methods of using such compositions for treating cancer are described.
10669326 Peptides, combination of peptides as targets and for use in immunotherapy against gallbladder cancer and cholangiocarcinoma and other cancers  
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The...
10669325 Uterine cancer treatments  
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The...
10669310 Peptide for cancer treatment and pharmaceutical composition containing same  
The present invention provides peptides containing a structure in which a portion of the dominant negative peptide of BIG3 which inhibits the interaction between BIG3 and PHB2 is substituted with...
10669234 Cyanopyrrolidines as dub inhibitors for the treatment of cancer  
The present invention relates to novel compounds and method for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In particular, the invention relates to the inhibition of...
10668174 Organ protection in PSMA-targeted radionuclide therapy of prostate cancer  
A method of reducing radiation exposure of a non-cancerous tissue of a patient diagnosed with a cancer includes administering to the patient an agent capable of competing for binding sites on a...
10668166 Antibody-drug-conjugates comprising novel anthracycline-derivatives for cancer treatment  
The present invention relates to novel anthracycline derivatives comprising two oxazolidine cycles and the preparation of said anthracycline derivatives. Furthermore, antibody-drug conjugates...
10668152 Use of anti-PD-1 antibody in combination with anti-CD27 antibody in cancer treatment  
This disclosure provides methods for treating cancer in a subject comprising administering to the subject an anti-PD-1 antibody and an anti-CD27 antibody. In some embodiments, the cancer is...
10668151 Nanoparticle complexes of albumin, paclitaxel, and panitumumab for treatment of cancer  
This invention relates to antibody-albumin nanoparticle complexes comprising albumin, an antibody with binding specificity for a cancer antigen (e.g. panitumumab), and paclitaxel, wherein the...
10668138 Peptides and combination of peptides for use in immunotherapy against pancreatic cancer and other cancers  
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The...
10668130 Formulation for targeting cancer in humans and canines using chlorotoxin  
The present invention provides formulation/composition comprising phytonutrients with natural chlorotoxins for targeting cancer, infection, inflammation and pain without any side effects and a...
10668125 Peptide having highly-shifted accumulation to pancreatic cancer cells and tissues, and use of said peptide  
Disclosed is a peptide of the following (a) or (b): (a) a peptide containing an amino acid sequence including a sequence set forth in any one of SEQ ID NOS: 1, 2, 3, and 4; and (b) a peptide...
10668113 Formulation for targeting cancer in humans and canines using venom  
The present invention provides formulation/composition comprising phytonutrients with natural chlorotoxins for targeting cancer, infection, inflammation and pain without any side effects and a...
10668112 Formulation for targeting cancer in humans and canines  
The present invention provides formulation/composition comprising phytonutrients with natural chlorotoxins for targeting cancer, infection, inflammation and pain without any side effects and a...
10668093 Method for prolonging the over survival of a cancer patient  
The present invention relates to a method for treating a cancer with the combination of a topoisomerase II inhibitor (TOP2 inhibitor) and a histone deacetylation inhibitor (HDACi), provides...
10668078 Methods and compositions for treating mesothelioma and small lung cancer that express midkine  
Embodiments provided herein relate to methods and compositions for treating mesothelioma and/or a small cell lung cancer that express midkine.
10668068 Treating cancer with drug combinations  
Embodiments of the invention find application in the field of cancer therapy. Receptor protein kinases (RPTKs) transmit extracellular signals across the plasma membrane to cytosolic proteins,...
10668063 Method of treating cancer associated with a RAS mutation  
Disclosed herein are methods of treating a cancer characterized by expressing a mutant form of a RAS protein. Some embodiments relate to treatment of cancer by administering Plinabulin to a...
10668055 Cancer treatment using combinations of ERK and RAF inhibitors  
The present invention provides, inter alia, methods of treating or ameliorating the effects of a cancer in a subject. The methods include administering to the subject an effective amount of (i) a...
10668028 Methods and use of inducing apoptosis in cancer cells  
The present disclosure relates to a method of inducing apoptosis in a cancer cell by delivery of exogenous Coenzyme Q1O or its metabolites thereof in a pharmaceutically acceptable carrier to...
10667749 Device, method and system for implementing a physical area network for cancer immunotherapy  
A physical area network described herein enables significantly improved health monitoring and treatment by utilizing internal (in-body) mechanisms and information and external mechanisms and...
10667718 Quantitative prostate cancer imaging with magnetic resonance fingerprinting (MRF)  
Example embodiments associated with characterizing a sample using NMR fingerprinting are described. One example NMR apparatus includes an NMR logic that repetitively and variably samples a (k, t,...
10663470 Immunoassay of S-adenosylmethionine in personalized medicine and health or cancer evaluation  
The invention provides a method of detecting the presence or absence of a disease in a patient wherein said disease is accompanied by deficient levels of S-adenosylmethionine comprising:...