Match Document Document Title Score
WO/2010/056795A1 NOVEL SYNTHETIC DINUCLEOSIDE POLYPHOSPHATE ANALOGS AND THEIR USE AS NEW THERAPEUTIC AND/OR DIAGNOSTIC MODALITIES  
The invention provides novel synthetic dinucleoside polyphosphate analogs and their use as therapeutic compounds and/or diagnostic tools for the treatment and diagnosis of various human diseases...
1000
WO/1997/040840A1 P1, P4-DITHIO-P2,P3-MONOCHLOROMETHYLENE 5', 5'''-DIADENOSINE P1, P4-TETRAPHOSPHATE AS ANTITHROMBOTIC AGENT  
A novel composition, P1, P4-dithio-P2, P3-monochloromethylene 5', 5'''-diadenosine P1, P4-tetraphosphate, is disclosed. The composition is useful as a therapeutic agent for prevention of...
945
WO/2002/094848A1 TREATMENT OF MYCOBACTERIUM TUBERCULOSIS WITH ANTISENSE OLIGONUCLEOTIDES  
Methods of inhibiting the proliferation of Mycobacterium tuberculosis comprising contacting Mycobacterium tuberculosis with an effective amount of a polynucleotide complementary to an mRNA...
927
WO/2009/029868A1 PHOSPHORAMIDITE NUCLEOSIDE ANALOGS  
Described are phosphoramidite nucleoside analog monomers, precursors thereof, and oligonucleotides including one or more of the monomers. The monomers can be used during automated synthesis of...
893
WO/2008/063806A3 MEDICAL DEVICE COATINGS AND COATED STENTS  
The invention provides a medical device coated with Ap4A and/or an Ap4A analog. In a preferred embodiment the medical device is a vascular stent.
891
WO/2008/063806A2 MEDICAL DEVICE COATINGS AND COATED STENTS  
The invention provides a medical device coated with Ap4A and/or an Ap4A analog. In a preferred embodiment the medical device is a vascular stent.
891
WO/1998/002448A1 CONJUGATES OF MINOR GROOVE DNA BINDERS WITH ANTISENSE OLIGONUCLEOTIDES  
Compositions of antisense oligonucleotides conjugated to peptides of a plurality of N-methylpyrrolecarboxamides linked by peptide bonds is provided. The compositions form stable hybridization...
878
US20060183676 Treatment of mycobacterium tuberculosis with antisense oligonucleotides  
Methods of inhibiting the proliferation of Mycobacterium tuberculosis comprising contacting Mycobacterium tuberculosis with an effective amount of a polynucleotide complementary to an mRNA...
871
5049550 Diadenosine 5', 5'"-p1, p4,-tetraphosphate analogs as antithrombotic agents  
A component of blood platelets analogues thereof are described. The invention is based on the discovery that this component, a dinucleotide, as well as several of its chemically synthesized...
828
US20100286765 Medical Device Coatings and Coated Stents  
The invention provides a medical device coated with Ap4A and/or an Ap4A analog. In a preferred embodiment the medical device is a vascular stent.
819
5681823 P1, P4 -dithio-P2 -P3 -monochloromethylene 5', 5'"-diadenosine P1, P4 -tetraphosphate as antithrombotic agent  
A novel composition, P1, P4 -dithio-P2, P3 -monochloromethylene 5', 5'"-diadenosine P1, P4 -tetraphosphate, is disclosed. The composition is useful as a therapeutic agent for prevention of...
816
WO/2005/094370A2 OLIGONUCLEOTIDE COMPLEX COMPOSITIONS AND METHODS OF USE AS GENE ALTERATION TOOLS  
Compositions and methods of treatments of cells are provided for altering the phenotype of a cell by administering an oligonucleotide complex to the cell, the complex having two strands and...
758
5616564 Antiparasitic oligonucleotides active against drug resistant malaria  
The invention provides methods and materials for antisense oligonucleotide therapy against active pathogenic infection by drug resistant or drug sensitive pathogens, including Plasmodium falciparum.
738
WO/2001/046473A1 TREATMENT OF MYCOBACTERIUM TUBERCULOSIS WITH ANTISENSE POLYNUCLEOTIDES  
Methods of inhibiting the proliferation of Mycobacterium tuberculosis comprising contacting Mycobacterium tuberculosis with an effective amount of a polynucleotide complementary to an mRNA...
732
WO/1998/021323A2 REVERSAL OF DRUG RESISTANCE THROUGH OLIGONUCLEOTIDE COMPLEMENTARY TO PLASMODIUM FALCIPARUM SPECIFIC REGION  
The present invention provides methods of resensitizing an anti-drug-resistant infectious agent to a drug. Also disclosed are synthetic oligonucleotides having a nucleotide sequence complementary...
725
US20040033972 Treatment of mycobacterium tuberculosis with antisense polynucleotides  
Methods of inhibiting the proliferation of Mycobacterium tuberculosis comprising contacting Mycobacterium tuberculosis with an effective amount of a polynucleotide complementary to an mRNA...
708
8084589 Phosphoramidite nucleoside analogs  
Described are phosphoramidite nucleoside analog monomers, precursors thereof, and oligonucleotides including one or more of the monomers. The monomers can be used during automated synthesis of...
703
US20090136940 PHOSPHORAMIDITE NUCLEOSIDE ANALOGS  
Described are phosphoramidite nucleoside analog monomers, precursors thereof, and oligonucleotides including one or more of the monomers. The monomers can be used during automated synthesis of...
685
WO/2010/030751A2 NEW MODALITIES FOR TREATMENT OF DRUG-RESISTANT TUBERCULOSIS AND OTHER DISEASES  
The invention provides antibacterial compounds comprising an oligonucleotide having a sequence complementary to a translation initiation region of an mRNA encoding a mycolyl transferase of...
682
US20120252880 Oligonucleotide Complex Compositions And Methods Of Use As Gene Alteration Tools  
Compositions and methods of treatments of cells are provided for altering the phenotype of a cell by administering an oligonucleotide complex to the cell, the complex having two strands and...
675
5929226 Antisense oligonucleotide alkylphosphonothioates and arylphospohonothioates  
The invention provides improved oligonucleotides having greater resistance to nucleolytic degradation by virtue of having alkylphosphonothioate or arylphosphonothioate internucleotide linkages.
661
6335436 Oligonucleotides active against drug-resistant bacteria  
The invention discloses methods and materials for the utilization of chemically modified oligonucleotides in the treatment of drug-resistant bacterial infections including drug-resistant tuberculosis.
660
8841271 Oligonucleotide complex compositions and methods of use as gene alteration tools  
Compositions and methods of treatments of cells are provided for altering the phenotype of a cell by administering an oligonucleotide complex to the cell, the complex having two strands and...
653
5149798 Process for synthesizing oligonucleotides and their analogs adaptable to large scale syntheses  
A process of producing synthetic oligonucleotides on a small or large scale using H-phosphonate nucleoside monomers is described. The process can be used to synthesize oligonucleotides of any...
650
4806463 Inhibition of HTLV-III by exogenous oligonucleotides  
Inhibition of HTLV-III by adminstration of an oligonucleotide complementary to highly conserved regions of the HTLV-III genome necessary for HTLV-III replication and/or gene expression is...
635
US20030186911 Inhibition of infectious agents by exogenous oligonucleotides  
Inhibition of replication of an infectious agent, gene expression of an infectious agent, or both, by administration of an oligonucleotide complementary to highly conserved regions of the...
621
US20030191078 Inhibition of infectious agents by exogenous oligonucleotides  
Inhibition of replication of an infectious agent, gene expression of an infectious agent, or both, by administration of an oligonucleotide complementary to highly conserved regions of the...
621
US20080287379 Oligonucleotide Complex Compositions and Methods of Use as Gene Alteration Tools  
Compositions and methods of treatments of cells are provided for altering the phenotype of a cell by administering an oligonucleotide complex to the cell, the complex having two strands and...
615
WO/1997/024146A1 CARDIOVASCULAR AND THROMBUS IMAGING AGENTS, METHODS AND KITS  
The invention provides cardiovascular imaging agents comprising a radionuclide in association with a nucleotide polyphosphate targeting molecule. Methods for using the cardiovascular imaging...
609
WO/2010/030751A9 NEW MODALITIES FOR TREATMENT OF DRUG-RESISTANT TUBERCULOSIS AND OTHER DISEASES   598
WO/1997/011170A2 ANTISENSE OLIGONUCLEOTIDE CHEMOTHERAPY FOR BENIGN HYPERPLASIA OR CANCER OF THE PROSTATE  
Methods of selectively inhibiting the growth of or killing prostatic cells, using antisense oligonucleotides to prostate specific genes, are disclosed. The oligonucleotides may have natural...
594
WO/1991/012323A1 METHOD OF SITE-SPECIFIC ALTERATION OF RNA AND PRODUCTION OF ENCODED POLYPEPTIDES  
A method of site-directed alteration (removal or removal followed by replacement) of selected nucleotides in an RNA molecule, as well as to mixed phosphate backbone oligonucleotides useful in the...
592
WO/1997/011172A1 ANTISENSE OLIGONUCLEOTIDE CHEMOTHERAPY FOR BENIGN HYPERPLASIA OR CANCER OF THE PROSTATE  
Methods of selectively inhibiting the growth of or killing prostatic cells, using antisense oligonucleotides to prostate specific genes, are disclosed. The oligonucleotides may have natural...
586
8314226 Oligonucleotide complex compositions and methods of use as gene alteration tools  
Compositions and methods of treatments of cells are provided for altering the phenotype of a cell by administering an oligonucleotide complex to the cell, the complex having two strands and...
586
WO/1997/011170A1 ANTISENSE OLIGONUCLEOTIDE CHEMOTHERAPY FOR BENIGN HYPERPLASIA OR CANCER OF THE PROSTATE  
Methods of selectively inhibiting the growth of or killing prostatic cells, using antisense oligonucleotides to prostate specific genes, are disclosed. The oligonucleotides may have natural...
571
WO/1996/023878A1 HUMAN IMMUNODEFICIENCY VIRUS TRANSCRIPTION INHIBITORS AND METHODS OF THEIR USE  
Disclosed are methods of inhibiting transcription using a synthetic oligonucleotide complementary to the Watson strand of a double-stranded DNA genome. Also disclosed are synthetic...
570
5635377 Method of site-specific alteration of RNA and production of encoded polypeptides  
A method of site-directed alteration (removal or removal followed by replacement) of selected nucleotides in an RNA molecule, as well as to mixed phosphate backbone oligonucleotides useful in the...
555
US20150284708 Oligonucleotide Complex Compositions  
Compositions and methods of treatments of cells are provided for altering the phenotype of a cell by administering an oligonucleotide complex to the cell, the complex having two strands and...
552
5366878 Method of site-specific alteration of RNA and production of encoded polypeptides  
A method of site-directed alteration (removal or removal followed by replacement) of selected nucleotides in an RNA molecule, as well as to mixed phosphate backbone oligonucleotides useful in the...
539
9617535 Oligonucleotide complex compositions and methods of use as gene alteration tools  
Compositions and methods of treatments of cells are provided for altering the phenotype of a cell by administering an oligonucleotide complex to the cell, the complex having two strands and...
535
5637573 Influenza virus replication inhibiting oligonucleotide analogues and their pharmaceutical compositions  
A method of inhibiting influenza virus replication through the activity of natural (unmodified) or modified oligonucleotides (oligodeoxynucleotides or oligoribonucleotides) which hybridize to a...
534
5898066 Trophic factors for central nervous system regeneration  
Cell culture conditions were developed which maintain the nerve cells of the retina in well-defined, serum-free conditions. The molecular factors that stimulate axonal regeneration from these...
525
5998602 RNase L activators and antisense oligonucleotides effective to treat RSV infections  
The invention concerns a compounds and methods for treating infection with Respiratory Syncytial Virus. The compounds comprise an antisense portion, which is complementary to a normally single...
521
US20100204310 NEW MODALITIES FOR TREATMENT OF DRUG-RESISTANT TUBERCULOSIS AND OTHER DISEASES  
The invention provides antibacterial compounds comprising an oligonucleotide having a sequence complementary to a translation initiation region of an mRNA encoding a mycolyl transferase of...
517
6214805 RNase L activators and antisense oligonucleotides effective to treat RSV infections  
The present invention relates to methods of inhibiting infection by RNA viruses with complexes of an activator of RNase L and an oligonucleotide that is capable of binding to the genome,...
510
WO/2001/003668A1 PULMONARY DELIVERY OF LIPOSOME-ENCAPSULATED CANNABINOIDS  
A liposomal composition containing a cannabinoid or cannabimimetic agent and methods of systemic delivery by contacting pulmonary tissue of a mammal with the liposomal composition to achieve a...
499
6197944 DNA molecules stabilized by modifications of the 3'-terminal phosphodiester linkage  
The use of oligodeoxynucleotides modified at the 3'-terminal internucleotide link as therapeutic agents by a method of hybridizing the modified oligonucleotide to a complementary sequence within a...
498
6440660 Oligonucleotide mediated reversal of drug resistance  
The present invention provides methods of resensitizing an anti-drug-resistant infectious agent to a drug. Also disclosed are synthetic oligonucleotides having a nucleotide sequence complementary...
498
5149797 Method of site-specific alteration of RNA and production of encoded polypeptides  
A method of site-directed alteration (removal or removal followed by replacement) of selected nucleotides in an RNA molecule, as well as to mixed phosphate backbone oligonucleotides useful in the...
496
5220007 Method of site-specific alteration of RNA and production of encoded polypeptides  
A method of site-directed alteration (removal or removal followed by replacement) of selected nucleotides in an RNA molecule, as well as to mixed phosphate backbone oligonucleotides useful in the...
484


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