Matches 1 - 50 out of 53 1 2 >


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WO/2020/086970A1 DETECTION METHOD FOR NATURAL AND MODIFIED SMALL NUCLEIC ACIDS  
The invention relates to a method for the detection of natural or modified nucleic acids by their sequence specific hybridization with charge-modified oligonucleotide probes having...
1000
WO/2005/094370A3 OLIGONUCLEOTIDE COMPLEX COMPOSITIONS AND METHODS OF USE AS GENE ALTERATION TOOLS  
Compositions and methods of treatments of cells are provided for altering the phenotype of a cell by administering an oligonucleotide complex to the cell, the complex having two strands and...
744
WO/2010/030751A2 NEW MODALITIES FOR TREATMENT OF DRUG-RESISTANT TUBERCULOSIS AND OTHER DISEASES  
The invention provides antibacterial compounds comprising an oligonucleotide having a sequence complementary to a translation initiation region of an mRNA encoding a mycolyl transferase of...
732
WO/2010/030751A9 NEW MODALITIES FOR TREATMENT OF DRUG-RESISTANT TUBERCULOSIS AND OTHER DISEASES   732
WO/2002/094848A8 TREATMENT OF MYCOBACTERIUM TUBERCULOSIS WITH ANTISENSE OLIGONUCLEOTIDES  
Methods of inhibiting the proliferation of Mycobacterium tuberculosis comprising contacting Mycobacterium tuberculosis with an effective amount of a polynucleotide complementary to an mRNA...
732
WO/2010/056795A1 NOVEL SYNTHETIC DINUCLEOSIDE POLYPHOSPHATE ANALOGS AND THEIR USE AS NEW THERAPEUTIC AND/OR DIAGNOSTIC MODALITIES  
The invention provides novel synthetic dinucleoside polyphosphate analogs and their use as therapeutic compounds and/or diagnostic tools for the treatment and diagnosis of various human diseases...
722
WO/2005/094370A2 OLIGONUCLEOTIDE COMPLEX COMPOSITIONS AND METHODS OF USE AS GENE ALTERATION TOOLS  
Compositions and methods of treatments of cells are provided for altering the phenotype of a cell by administering an oligonucleotide complex to the cell, the complex having two strands and...
722
WO/2002/094848A1 TREATMENT OF MYCOBACTERIUM TUBERCULOSIS WITH ANTISENSE OLIGONUCLEOTIDES  
Methods of inhibiting the proliferation of Mycobacterium tuberculosis comprising contacting Mycobacterium tuberculosis with an effective amount of a polynucleotide complementary to an mRNA...
708
WO/2009/029868A1 PHOSPHORAMIDITE NUCLEOSIDE ANALOGS  
Described are phosphoramidite nucleoside analog monomers, precursors thereof, and oligonucleotides including one or more of the monomers. The monomers can be used during automated synthesis of...
708
WO/2004/065008A1 METHODS FOR REMOVING MICROBICIDAL COMPOUNDS FROM COMPOSITIONS  
Methods for removal of positively charged microbicidal compound, in particular an aziridino compound, from composition such as a blood product by contacting the composition with a cation exchange...
708
WO/2005/099369A3 EMR TREATED ISLETS  
Methods of treatment of tissue (204) with electromagnetic radiation (EMR) to produce lattices of EMR-treated islets (244) in the tissue (204) are disclosed. Also disclosed are devices and systems...
708
WO/2005/099369A2 EMR TREATED ISLETS  
Methods of treatment of tissue (204) with electromagnetic radiation (EMR) to produce lattices of EMR-treated islets (244) in the tissue (204) are disclosed. Also disclosed are devices and systems...
708
WO/2014/011053A1 OLIGONUCLEOTIDES FOR MAKING A CHANGE IN THE SEQUENCE OF A TARGET RNA MOLECULE PRESENT IN A LIVING CELL  
The present invention relates to the field of gene therapy, more specifically to oligonucleotides for making a change in the sequence of a target RNA molecule present in a living cell
700
US20120252880 Oligonucleotide Complex Compositions And Methods Of Use As Gene Alteration Tools  
Compositions and methods of treatments of cells are provided for altering the phenotype of a cell by administering an oligonucleotide complex to the cell, the complex having two strands and...
662
8841271 Oligonucleotide complex compositions and methods of use as gene alteration tools  
Compositions and methods of treatments of cells are provided for altering the phenotype of a cell by administering an oligonucleotide complex to the cell, the complex having two strands and...
637
10738005 Aziridinyl containing compounds and methods of inactivating nucleic acid molecules using the same  
Described herein are compositions and compounds having one or more aziridinyl groups, and methods of making the same. The compounds can also have one or more nitrogen atoms that each can be...
627
US20190106386 AZIRIDINYL CONTAINING COMPOUNDS AND METHODS OF INACTIVATING NUCLEIC ACID MOLECULES USING THE SAME  
Described herein are compositions and compounds having one or more aziridinyl groups, and methods of making the same. The compounds can also have one or more nitrogen atoms that each can be...
623
WO/2020/023881A1 METHOD FOR PATHOGENS, MICROORGANISMS, AND PARASITES INACTIVATION  
The invention provides a method for inactivation or reduction of pathogens, microorganisms or parasites in a sample, media, composition, utility, device, surface or organism by treatment with an...
604
US20080287379 Oligonucleotide Complex Compositions and Methods of Use as Gene Alteration Tools  
Compositions and methods of treatments of cells are provided for altering the phenotype of a cell by administering an oligonucleotide complex to the cell, the complex having two strands and...
601
US20150284708 Oligonucleotide Complex Compositions  
Compositions and methods of treatments of cells are provided for altering the phenotype of a cell by administering an oligonucleotide complex to the cell, the complex having two strands and...
593
10173976 Aziridinyl containing compounds and methods of inactivating nucleic acid molecules using the same  
Described herein are compositions and compounds having one or more aziridinyl groups, and methods of making the same. The compounds can also have one or more nitrogen atoms that each can be...
593
US20160289182 AZIRIDINYL CONTAINING COMPOUNDS AND METHODS OF INACTIVATING NUCLEIC ACID MOLECULES USING THE SAME  
Described herein are compositions and compounds having one or more aziridinyl groups, and methods of making the same. The compounds can also have one or more nitrogen atoms that each can be...
593
US20170320902 PHOSPHORAMIDITE SYNTHONES FOR THE SYNTHESIS OF SELF-NEUTRALIZING OLIGONUCLEOTIDE COMPOUNDS  
Compositions and compounds having nucleoside phosphoramidites, and methods of making the same are provided. The compounds can also have one or more amino groups that each can be positively...
593
US20120277659 SENSOR-LOTION SYSTEM FOR USE WITH BODY TREATMENT DEVICES  
Controls improve skin and/or eye safety for use of a light based photocosmetic device. The sensors having high spatial resolution and the low probability of sensor failure and improve skin and/or...
556
US20060183676 Treatment of mycobacterium tuberculosis with antisense oligonucleotides  
Methods of inhibiting the proliferation of Mycobacterium tuberculosis comprising contacting Mycobacterium tuberculosis with an effective amount of a polynucleotide complementary to an mRNA...
556
WO/2016/081600A1 PHOSPHORAMIDITE SYNTHONES FOR THE SYNTHESIS OF SELF-NEUTRALIZING OLIGONUCLEOTIDE COMPOUNDS  
Compositions and compounds having nucleoside phosphoramidites, and methods of making the same are provided. The compounds can also have one or more amino groups that each can be positively...
556
WO/2015/073622A1 AZIRIDINYL CONTAINING COMPOUNDS AND METHODS OF INACTIVATING NUCLEIC ACID MOLECULES COMPRISING THE SAME  
Described herein are compositions and compounds having one or more aziridinyl groups, and methods of making the same. The compounds can also have one or more nitrogen atoms that each can be...
556
10723755 Phosphoramidite synthones for the synthesis of self-neutralizing oligonucleotide compounds  
Compositions and compounds of nucleoside phosphoramidites and modified oligonucleotides, each comprising one or more charge-neutralizing moieties according to the formula V wherein represents the...
552
9617535 Oligonucleotide complex compositions and methods of use as gene alteration tools  
Compositions and methods of treatments of cells are provided for altering the phenotype of a cell by administering an oligonucleotide complex to the cell, the complex having two strands and...
497
US20090069741 Methods And Devices For Fractional Ablation Of Tissue For Substance Delivery  
Methods and devices for ablating portions of a tissue volume with electromagnetic radiation (EMR) to produce lattices of EMR-treated ablation islets in the tissue are disclosed, including lattices...
482
US20100204310 NEW MODALITIES FOR TREATMENT OF DRUG-RESISTANT TUBERCULOSIS AND OTHER DISEASES  
The invention provides antibacterial compounds comprising an oligonucleotide having a sequence complementary to a translation initiation region of an mRNA encoding a mycolyl transferase of...
478
8314226 Oligonucleotide complex compositions and methods of use as gene alteration tools  
Compositions and methods of treatments of cells are provided for altering the phenotype of a cell by administering an oligonucleotide complex to the cell, the complex having two strands and...
476
WO/2003/089462A2 TUBERCULOSIS VACCINES INCLUDING RECOMBINANT BCG STRAINS EXPRESSING ALANINE DEHYDROGENASE, SERINE DEHYDRATASE AND/OR GLUTAMINE SYNTHETASE  
The invention relates to a live recombinant Mycobacterium bovis-BCG strain comprising a nucleic acid capable of expression, the nucleic acid encoding at least one protein or polypeptide that...
462
7611720 Tuberculosis vaccines including recombinant BCG strains expressing alanine dehydrogenase, serine dehydratase and/or glutamine synthetase  
The invention relates to a live recombinant Mycobacterium bovis-BCG strain comprising a nucleic acid capable of expression, the nucleic acid encoding at least one protein or polypeptide that...
422
US20070264286 Tuberculosis Vaccines Including Recombinant BCG Strains Expressing Alanine Dehydrogenase, Serine Dehydratase and/or Glutamine Synthetase  
The invention relates to a live recombinant Mycobacterium bovis-BCG strain comprising a nucleic acid capable of expression, the nucleic acid encoding at least one protein or polypeptide that...
422
US20040137419 Methods for removing microbicidal compounds from compositions  
Methods for removal of positively charged microbicidal compounds from biological compositions are provided.
421
8084589 Phosphoramidite nucleoside analogs  
Described are phosphoramidite nucleoside analog monomers, precursors thereof, and oligonucleotides including one or more of the monomers. The monomers can be used during automated synthesis of...
414
WO/2019/094434A1 THERAPEUTIC COMBINATION FOR TREATMENT OF CEREBELLAR ATAXIA  
Provided herein are combinations of therapeutic agents useful for the treatment of cerebellar ataxia and methods of use thereof. In particular, embodiments herein baclofen and chlorzoxazone are...
397
US20110257584 METHODS AND DEVICES FOR INJECTION OF A SUBSTANCE INTO TISSUE  
Substances are injected (e.g. laser injected) into skin tissue in order to change optical and/or mechanical properties of the tissue. Methods include ablating one or more micro-holes into tissue,...
382
US20090136940 PHOSPHORAMIDITE NUCLEOSIDE ANALOGS  
Described are phosphoramidite nucleoside analog monomers, precursors thereof, and oligonucleotides including one or more of the monomers. The monomers can be used during automated synthesis of...
382
US20080069802 Modified Virus  
Modified viral particles wherein the viral particles, typically adenoviral particles, are modified by glycosylation and the use of the modified viral particles to deliver heterologous nucleic acid...
355
8815563 Modified virus  
Modified viral particles wherein the viral particles, typically adenoviral particles, are modified by glycosylation and the use of the modified viral particles to deliver heterologous nucleic acid...
355
WO/2006/008513A1 MODIFIED VIRUS  
We disclose modified viral particles wherein the viral particles, typically adenoviral particles, are modified by glycosylation and the use of the use of the modified viral particles to deliver...
355
US20190134007 THERAPEUTIC COMBINATION FOR TREATMENT OF CEREBELLAR ATAXIA  
Provided herein are combinations of therapeutic agents useful for the treatment of cerebellar ataxia and methods of use thereof. In particular, embodiments herein baclofen and chlorzoxazone are...
311
US20060004347 Methods and products for producing lattices of EMR-treated islets in tissues, and uses therefor  
Methods of treatment of tissue with electromagnetic radiation (EMR) to produce lattices of EMR-treated islets in the tissue are disclosed. Also disclosed are devices and systems for producing...
237
US20060058712 Methods and products for producing lattices of EMR-treated islets in tissues, and uses therefor  
Methods of treatment of tissue with electromagnetic radiation (EMR) to produce lattices of EMR-treated islets in the tissue are disclosed. Also disclosed are devices and systems for producing...
237
US20100145321 METHODS AND PRODUCTS FOR PRODUCING LATTICES OF EMR-TREATED ISLETS IN TISSUES, AND USES THEREFOR  
Methods of treatment of tissue with electromagnetic radiation (EMR) to produce lattices of EMR-treated islets in the tissue are disclosed. Also disclosed are devices and systems for producing...
237
10093924 Multimetric oligonucleotide compounds  
The disclosure provides multimeric oligonucleotide compounds, comprising two or more target-specific oligonucleotides (e.g., antisense oligonucleotides (ASOs)), each being resistant to cleavage,...
194
9732341 Methods of delivering multiple targeting oligonucleotides to a cell using cleavable linkers  
The disclosure provides multimeric oligonucleotide compounds, comprising two or more target-specific oligonucleotides (e.g., antisense oligonucleotides (ASOs)), each being resistant to cleavage,...
194
9732340 Multimeric oligonucleotides compounds having cleavable linkers  
The disclosure provides multimeric oligonucleotide compounds, comprising two or more target-specific oligonucleotides (e.g., antisense oligonucleotides (ASOs)), each being resistant to cleavage,...
194


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