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DE102014016901B4 Process for the production of new dextran derivatives as active ingredient carrier systems and their use  
Process for the preparation of dextran amino acid esters of the general formula I:in which R, independently of one another, can be H and at least one amino acid with at least one amino group which...
DE202019005567U1 New CRISPR DNA Targeting Enzymes and Systems  
A constructed, non-naturally occurring Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR) - associated (Cas) system, comprising: (a) a guide RNA or a nucleic acid encoding the guide...
DE102016216657B4 Eukaryotic adult cells comprising a transfection system and its preparation and use  
A eukaryotic adult cell comprising a transfection system, wherein the transfection system (i) a cationic polymer having amino groups which are at least partially biotinylated, (ii) magnetic...
DE102017003004A1 Cationic polymers with D-fructose substituents  
The invention relates to novel cationic polymers which are D-fructose conjugated, whereby they are able to interact selectively with specific structural elements on cell surfaces. The task was to...
DE102017103383A1 System and method for cell-type specific translation of RNA molecules in eukaryotes  
The present technology encompasses methods and RNA constructs for the targeted translation of a polypeptide of interest into a target eukaryotic cell, as well as their use in therapeutically...
DE102016113714A1 Transfection procedures with non-viral gene delivery systems  
The present invention discloses a transfection method for introducing nucleic acids into eukaryotic cells by means of a non-viral gene delivery system, the cells before and / or during the...
DE102015101838A1 Method and apparatus for reprogramming of living cells  
The invention relates to a method and apparatus for reprogramming of living cells. The object, a new way to direct, efficient and rapid cell reprogramming without the use of viruses to find in...
DE102014016901A1 New dextran derivatives as drug delivery systems  
The task was to find vectors for the transfection of active substances in cells which are characterized by a high transfection rate, low toxicity and high biocompatibility and which can be...
DE102014015418B3 Microsystems and methods for manipulation of biological material  
A microsystem (2) for the manipulation of biological materials, especially living cells (4), with a first arm (6), one to the first arm (6) the second arm (10) mechanically connected, and a drive...
DE69034168T3 Expression of exogenous polynucleotide sequences in vertebrates  
A method for delivering an isolated polynucleotide to the interior of a cell in a vertebrate, comprising the interstitial introduction of an isolated polynucleotide into a tissue of the vertebrate...
DE69535540T9 COMPOSITION CONTAINING NUCLEIC AND CATIONIC POLYMERS, PREPARATION AND USE  
PCT No. PCT/FR95/00914 Sec. 371 Date Feb. 28, 1997 Sec. 102(e) Date Feb. 28, 1997 PCT Filed Jul. 7, 1995 PCT Pub. No. WO96/02655 PCT Pub. Date Feb. 1, 1996Compositions containing one or more...
DE19925052B4 Protein complexes for the targeted transport of (poly) peptides and nucleic acids and site-specific integration of DNA vectors  
Transport system to protein complex-based composition comprising a recombinase, z. B. HIV-1 integrase (10) which is fused to a sequence-specific DNA-binding domain (DBD) (6), which replaces a...
DE102005030986B4 Use of rotating magnetic nanoparticles  
Use of magnetic nanoparticles, which are set into rotating and longitudinal movements by superimposed alternating magnetic fields, - for transfection of cells, - for the identification, counting...
DE69534295T4 FIBRINOGENPRODUKTION IN TRANSGENIC ANIMALS  
Materials and methods for producing fibrinogen in transgenic non-human mammals are disclosed. DNA segments encoding Aα, Bβ and γ chains of fibrinogen are introduced into the germ line of a...
DE69534295T3 FIBRINOGENPRODUKTION IN TRANSGENIC ANIMALS  
Materials and methods for producing fibrinogen in transgenic non-human mammals are disclosed. DNA segments encoding Aα, Bβ and γ chains of fibrinogen are introduced into the germ line of a...
DE102008031666B4 cryocontainer  
Cryocontainer (40), suitable for storage and delivery of frozen particles (50), comprising: - A thermally insulating container element (41) having at least one receiving space (41a) for frozen...
DE102008045830A1 Method of treating a living biological material containing cells  
It is inter alia provided a method for treating a living biological material containing cells, by means of a plasma and at least one reactive species agents are at least partially placed in a part...
DE102008032829A1 Promoting and regulating biotechnological processes, comprises introducing polar crystals in form of nanoparticles and applying crystals into contact with biological material, stimulating crystals and promoting enzyme production process  
Promoting and regulating biotechnological processes, comprises: introducing electrically polar crystals in the form of nano- or micro-particles, either in bulk or enclosed in a filter basket, as...
DE102008031666A1 cryocontainer  
A storage and provision of frozen particles suitable cryogenic container comprising a thermally insulating container element having at least one receiving space for frozen particles and at least...
DE60226343T2 FOR GLUCOSE REGULATED PRODUCTION OF HUMAN INSULIN IN SOMATIC CELL LINES SUITABLE NUCLEIC CONSTRUCTS  
Unique multifunctional nucleotide expression cassettes comprising a nucleotide sequence encoding a human protease driven by a glucose-regulatable promoter, a nucleotide sequence encoding human...
DE60133585T2 MEMBRANE PENETRATING PEPTIDES AND THEIR APPLICATIONS  
The present invention is directed to membrane penetrating peptides useful as in vivo, ex vivo and in vitro intracellular delivery devices for compound of interest. More particularly, the invention...
DE60319103T2 SUBSTANCES FOR PREVENTION AND TREATMENT OF AUTOIMMUNE DISEASES  
A substance is disclosed for preventing, delaying the onset of or treating one or more than one autoimmune disease, the substance comprising a combination of a polynucleotide construct comprising...
DE60132670T2 Oligonucleotide-SUPPORTED COALESCENCE  
Coalescence of cells or other membrane-bound entities is facilitated by anchoring an outwardly projecting first oligonucleotide in one member and an outwardly projecting second oligonucleotide,...
DE60319161T2 Apparatus and method for the production, sorting and integration of materials by means of holographic optical traps  
An apparatus and method for manipulating, effecting interaction of, photochemically transforming and/or sorting small dielectric particles or other materials are disclosed. The apparatus and...
DE69334195T2 FORMATION OF ANTIBODY xenogeneic  
The subject invention provides non-human mammalian hosts characterized by inactivated endogenous Ig loci and functional human Ig loci for response to an immunogen to produce human antibodies or...
DE60131498T2 VIRUSHÜLLNVEKTOR FOR THE GENE  
A gene transfer vector is prepared by introducing an exogenous gene into an inactivated virus envelope, through a freezing and thawing treatment or mixing with a detergent. There are also provided...
DE102007015377A1 A process for preparing a transformed cell  
The This invention relates to a method for preparing a transformed cell comprising the steps of:i) Providing a nucleic acid,ii) incubating the Nucleic acid complex with a KI a transition metal and...
DE60037200T2 LOCAL-specific recombination FOR MANIPULATION plastid IN HIGHER PLANTS  
A site specific recombination system and methods of use thereof are disclosed for manipulating the genome of higher plants.
DE202008000954U1 Femtosecond laser system for material processing  
laser microscope for optical gene transfer, consisting of 1. Structure of the laser microscope 1 Femtosecond (NIR) laser with laser head and laser control 2 Dispersion compensation unit to achieve...
DE10251429B4 A rapid method to transform competent cells  
On fast method to transform competent cells with the steps: Thawing of competent cells in a container at room temperature or in a water bath; Mixing a plasmid DNA and the competent cells in the...
DE69232132T3 METHOD FOR CREATION OF A TRANSFORMED PLANT RICE  
A method of transforming rice is disclosed. The method begins with the preparation of copies of a nucleic acid construct that are coated onto biologically inert carrier particles. In one...
DE60223058T2 COMPOSITIONS AND METHODS FOR TREATING DIABETES  
The invention relates generally to chimeric peptides and compositions that facilitate the transport of insulin across biological membranes, methods for preparing the chimeric peptides, and a...
DE602005002621T2 EMPTY capsids (VLPs (-VP4)) OF THE Gumboro VERUSACHENDEN VIRUS (IBDV), METHOD FOR THE PRODUCTION AND APPLICATIONS  
The empty capsids of the infectious bursal disease virus (IBDV), VLP(-VP4), are characterized in that they are constituted only by assembly of IBDV pVP2 proteins and IBDV VP3 proteins. Said...
DE69535540T2 COMPOSITION CONTAINING NUCLEIC AND CATIONIC POLYMERS, PREPARATION AND USE  
PCT No. PCT/FR95/00914 Sec. 371 Date Feb. 28, 1997 Sec. 102(e) Date Feb. 28, 1997 PCT Filed Jul. 7, 1995 PCT Pub. No. WO96/02655 PCT Pub. Date Feb. 1, 1996Compositions containing one or more...
DE60316303T2 DEVICE AND METHOD FOR THE PRODUCTION, GRADING AND INTEGRATION OF MATERIALS PROCESSING HOLOGRAPHISCHEROPTISCHER FALLEN  
An apparatus and method for manipulating, effecting interaction of, photochemically transforming and/or sorting small dielectric particles or other materials are disclosed. The apparatus and...
DE60130324T2 OF HUMAN PROTEINS WHICH WITH HEPARIN REACT, amino acid sequences derived TO THE TRANSFER OF PRODUCTS OF INTEREST IN THE HEART OF CELLS AND / OR CELL CORES FACILITATE  
Amino acid sequences (I) that facilitate penetration of a substance of interest (II) into the inside of a cell and/or its nucleus. (I) can react in vivo with aminoglycans (AG) or can react with AG...
DE102005031427B4 Programmable apparatus and method for optimizing, and real-time monitoring of gene transfection on the basis of a user-configured arbitrary waveform pulse sequence  
device for generating arbitrary Waveform pulse sequences for a Elekroporationsprozeß, With - a Power module comprises: - A DC power supply array (DC) for providing an output voltage; - A...
DE60315296T2 Cell-selective delivery system  
The present invention relates to a method for predicting or designing, detecting, and/or verifying a novel cell-penetrating peptide (CPP) and to a method for using said new CPP and/or a novel...
DE60129206T2 METHOD FOR INCREASING THE GENE EXPRESSION OF GENES TRANSFECTED  
The present invention provides a method of increasing the gene expression of transfected genes which includes the administration of a carnitine.
DE19955576B4 Transfer compounds, their preparation and their use  
The invention relates to the use of a carboxy-terminal fragment of the Ki-67 protein or of an active part, fragment or homologue thereof as a compound that can be used for intracellular transfer...
DE19900284B4 A method for efficiently introducing DNA into eukaryotic cells using an adenoviral vector  
process for introducing DNA into eukaryotic cells, characterized that adenoviruses that contain the DNA to be inserted, with liposomes are preincubated and then with eukaryotic are brought into...
DE69837819T2 CONDENSED PLASMID LIPOSOME COMPLEX FOR Transfection  
An improvement in a method of preparing plasmid-liposome complexes for in vivo transfection is described. The improvement includes selecting a condensing agent to condense the plasmid prior to...
DE60034947T2 VIRUS LIKE PARTICLES, PREPARATION AND USE IN SCREENING AND FUNCTIONAL GENOME APPLICATION  
The invention relates to virus like particles, their preparation and their use in pharmaceutical screening and functional genomics. The invention further provides a variety of assay formats to be...
DE69837602T2 MICROPARTICLES FOR administration of nucleic acids  
Disclosed is a preparation of microparticles made up of a polymeric matrix and a nucleic acid expression vector. The polymeric matrix includes one or more synthetic polymers having a solubility in...
DE60128368T2 DIAGNOSIS AND TREATMENT OF PROSTATE CANCER  
A method of diagnosing cancer in a human patient comprising the steps of (i) obtaining a sample containing nucleic acid and/or protein from the patient; and (ii) determining whether the sample...
DE19933492B4 A conjugate for placement of a cell, or membrane compartment-specific transport of active substances, a process for its preparation and its use  
conjugate the presentation of a cell-, compartment-specific or membrane Transport, wherein the conjugate is in the order given the following components: - A penetratin having the following...
DE10109466B4 Method and means for modification of human angiogenesis  
process to induce angiogenic processes in tissues of a mammalian organism, comprising the steps of: - Preparation of a ternary complex by complexing a nucleic acid molecule as a functional...
DE69934690T2 GENE TRANSFER METHODS  
Improved methods for transferring a gene into target cells by using a retrovirus, wherein the gene transfer efficiency is improved and the target cells are efficiently transformed by binding the...
DE60033180T2 ON THE CATTLE IMMUNODEFICIENCY VIRUS (BIV) BASED VECTORS  
This invention pertains to BIV constructs encompassing BIV combination vectors, BIV vectors and BIV packaging vectors and particularly the invention pertains to a three vector system comprising:...
DE60217393T2 METHOD FOR COMBINED PARALLEL FEEDING AGENTS AND ELECTROPORATION FOR CELL STRUCTURES AND USE THEREOF  
Disclosed is a method for parallel delivery of agents to and/or into a cell structure, wherein at least two electrolyte-filled tubes are provided together with a counter electrode, the tubes being...

Matches 1 - 50 out of 250 1 2 3 4 5 >