Matches 1 - 50 out of 203 1 2 3 4 5 >


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DE102018211201B3 Sensor-effector cells for use in therapy  
The invention relates to the therapy of inflammation and / or cancer of the human or animal body and provides new cellular therapeutics that depend on a novel sensor-effector system in a...
DE102011118018B4 Minicircles with transposition cassettes and their use for transforming cells  
A minicircle comprising: a) at least one nucleic acid sequence of interest, and b) transposase recognition sequences on either side of the nucleic acid of interest, characterized in that the...
DE102011000036B4 Recombinant plasmid-containing multicopy CpG motifs and their transformants for use as DNA adjuvants in avian vaccines  
A transformant of a recombinant plasmid containing multi-copy CpG motifs is disclosed. The recombinant plasmid containing an immunostimulatory polynucleotide having a sequence of the continuous...
DE112014004537T5 Animal models and therapeutic molecules  
The invention discloses methods for generating chimeric human-nonhuman antibodies and chimeric antibody chains, thus produced include them fully humanized antibodies antibodies and antibody chains...
DE102011118018A1 New minicircle comprising nucleic acid sequence of interest and transposase recognition sequences on both sides of nucleic acid sequence of interest, useful for insertional mutagenesis or genetic transformation of eukaryotic target cell  
Minicircle comprising (a) at least one nucleic acid sequence of interest, and (b) transposase recognition sequences for both sides of (a), is new, where (b) are recognized for a specific...
DE102007003670B4 Double transgenic non-human mammal  
Double transgenic non-human mammal whose genome comprises a) a DNA sequence encoding (1), which codes for a proto-oncogene, and which is operatively connected to at least one regulatory sequence,...
DE102004031579B4 Peptides for inhibiting the interaction of protein kinase A and protein kinase A anchor proteins, the nucleic acid molecule comprising them, vector, host cell, the recognition molecule directed against them, the pharmaceutical composition containing them, the kit containing them and their use  
Polypeptide, characterized in that the polypeptide is selected from a group of amino acid sequences consisting of SEQ ID no. 20 to 27
DE102011018586A1 New vector system, useful e.g. as a part of a viral or non-viral gene transfer vector to control targeted expression of a therapeutic DNA sequence and as a part of transfer construct or gene construct for modifying embryonic stem cells  
Vector system is new, where the vector system is a part of a viral or non-viral gene transfer vector, in which a desired gene, a complementary DNA (cDNA) or a functional DNA segment linked to the...
DE102011000036A1 Recombinant plasmid-containing multicopy CpG motifs and their transformants for use as DNA adjuvants in bird vaccines  
A transformant of a recombinant plasmid containing multicopy CpG motifs is disclosed. The recombinant plasmid containing an immunostimulatory polynucleotide that has a sequence of the continuous...
DE102009013748B4 Determination of interactions constant antibody portions with Fc gamma receptors  
A recombinant expression vector comprising sequences for the recombinant expression of at least one fusion protein on the surface of a mammalian cell comprising a) an extracellular portion of a...
DE102009013748A1 Determination of interactions constant antibody portions with Fc gamma receptors  
The invention relates to a novel method for the exact determination of the binding of the Fc-portion of IgG antibodies to Fc-gamma receptors and for the simultaneous examination of the antigen...
DE102008063606A1 New nucleic acid construct, comprising first and second expression cassette comprising operatively linked e.g. constitutive expressing promoter, and minimal promoter, respectively, useful to prepare a product e.g. polypeptide or ribozyme  
Nucleic acid construct comprising (a) first expression cassette, which comprises operatively linked (i) a constitutive expressing promoter, and (ii) first component of transactivator system coding...
DE10053781B4 Nuclear Export Reporter System  
process for detecting RNA export from the nucleus of a eukaryotic Target cell, comprising the steps of: (A) providing a Nucleic acid, the for a reporter protein encoded and their transcript...
DE102007003670A1 Doubly transgenic nonhuman mammal useful as a lung cancer model has a genome including protooncogene and oncogene sequences  
Doubly transgenic nonhuman mammal (M1) has a genome including a protooncogene sequence (I) and an oncogene sequence (II), each linked to regulatory sequences. Independent claims are also included...
DE102004034461B4 Gene therapy of solid tumors by retroviral, with arena virus glycoprotein pseudotyped vectors  
use of packaging cells, retroviral, with arena virus glycoprotein pseudotyped virions produce, for preparing a pharmaceutical A composition for gene therapy of solid tumors, characterized in that...
DE19907485B4 Virus vaccine  
Protein vaccine, comprising a mixture of viral protein molecules, characterized in that the molecules are sequence variants a single viral protein or a portion thereof are.
DE60219221T2 DNA sequences having anti-repressor activity  
The invention is concerned with the systematic elucidation and identification of regulatory sequences. The invention provides among others screenings and detection methods with which regulatory...
DE60215502T2 A method of selecting a transcription-Modulatierenden DNA sequence using a vector with a transcriptional repression active element  
The invention is concerned with the systematic elucidation and identification of regulatory sequences. The invention provides among others screenings and detection methods with which regulatory...
DE19720839B4 Modular technology for the production of long, exact DNA constructs in vitro, in particular for the preparation of constructs for the production of artificial chromosomes (MAC, mammalian artificial chromosome) of two stable cloned DNA components and the prototype vector ditelomerische PTAT  
process for in vitro production of about 50 Kb long DNA constructs by directed, site-specific Recombination, characterized in that it comprises the steps of: a) Independent cloning of two DNA...
DE112004002170T5 Improved methods and compositions for RNA interference  
process to weaken the expression of a target nucleotide sequence in a eukaryotic Cell, said method comprising: introducing double-stranded RNA (DsRNA) into the eukaryotic cell to the expression of...
DE60210297T2 USE OF LONG pentraxin PTX3 FOR TREATING infertility in WOMEN  
The PTX3 gene or equivalent PTX3 activity is required for female fertility. Manipulation of PTX3 activity will regulate female fertility. The effects of female sterility may be ameliorated,...
DE10057014B4 A process for producing target cell-specific drugs  
process for producing a target cell-specific pharmaceutical composition comprising the steps: (A) Identification of at least two genes, whose expression in a target cell in comparison to the...
DE19754938B4 TGC method for inducing a targeted somatic transgenesis  
bacteria for use as a vehicle for gene and gene transfer in eukaryotic Cells of an organism for inducing a targeted somatic transgenesis in cells, tissues or organs, except the germ line of the...
DE20023745U1 Method of modulating expression of an endogenous cellular gene in a cell to prevent gene activation or prevent repression of gene expression comprising contacting a target sequence with a zinc finger protein  
Modulating expression of an endogenous cellular gene in a cell comprises contacting a first target site in the endogenous cellular gene with a first zinc finger protein (ZFP). ACTIVITY :...
DE102004034461A1 Gene therapy of solid tumors by retroviral, with arena virus glycoprotein pseudotyped vectors  
The This invention relates to the use of packaging cells, retroviral pseudotyped with arena virus glycoprotein virions produce, for preparing a pharmaceutical composition for gene therapy of solid...
DE102004031579A1 Peptides to inhibit the interaction of protein kinase A and protein kinase A anchor proteins  
The Invention relates to a nucleic acid sequence, the for Peptides encoded, the interaction of protein kinase A (PKA) and Protein kinase A anchor proteins (AKAP) inhibited, a host organism, the...
DE202004019129U1 Genetically-modified rodent for use in established experimental systems, exhibits homozygote knock-out of interferon receptor alpha-chain  
A genetically modified rodent exhibiting homozygote knock out of the interferon receptor alpha -chain, is new. An independent claim is also included for a cell from the transgenic animal.
DE10164819A1 A method for identifying target epitopes of the T-cell-mediated immune response and for the detection of epitope-specific T-cells  
The This invention relates to a method for the detection of epitope-specific T cells and target epitopes of reactive T-cells. The present invention relates to antigen Cells transduced with the...
DE10392358T5 Method and system for the in vivo analysis of developmental processes  
transgenic non-human animal comprising a HB9 Expressionsregulierelement, which is operably linked to a transgene.
DE10339927A1 A composition for prophylaxis / therapy of HBV infection and HBV-mediated diseases  
The This invention relates to compositions comprising at least two hepatitis B virus surface antigens (HBsAgs) containing fragments thereof and / or nucleic acids encoding them, which differ...
DE10311984A1 Using neutral endopeptidase-associated molecules for treatment, diagnosis, prophylaxis and monitoring of eating and metabolic disorders and dementia, also for drug development  
Use of NEP (= neutral endopeptidase)-associated molecules (I) to prepare a composition for diagnosis, prophylaxis, (secondary) treatment, and/or monitoring of non-immunological, non-hypertensive...
DE10256083A1 Expression vector, method for producing heterologous gene and selection methods for high producing recombinant cells  
An expression vector for eukaryotic cells comprising a gene encoding a protein of interest operably linked to a hamster ubiquitin / S27a promoter and a gene encoding a fluorescent protein....
DE10156863B4 A method for identifying target epitopes of the T-cell-mediated immune response and for the detection of epitope-specific T-cells  
Gene transfer vector containing a specific in antigen presenting cells inducible by the epitope-specific contact with a T-cell first promoter, a nucleic acid functionally linked to this first...
DE10254652A1 Knock-in mouse, useful in screening agents for treatment of epilepsy, contains a missense mutation in the beta2-subunit of the neuronal acetylcholine receptor  
Knock-in mouse (A) that has a missense mutation in the beta2 subunit (I) of the neuronal nicotinic acetylcholine receptor (R) Independent claims are also included for the following: (1) targeting...
DE10251918A1 Inheritable integration of DNA into germ-line invertebrate cells, useful for large-scale production of transgenic insects, includes post-transformational removal of mobilizable elements to increase stability  
Method for generating an inheritable integration of DNA into the genome of germ-line and somatic cells of an invertebrate, where the integration contains homologous or heterologous DNA sequences...
DE10141464A1 New nucleic acid representing a polymorphism in the 22444 gene, useful for diagnosis and treatment of neuropsychiatric diseases and in drug screening  
Nucleic acid (DNA) (I) comprising at least 10 nucleotides (nt) that represent a polymorphic fragment of the reference sequence of the 22444 gene (sequence of 10500 nt reproduced) or its...
DE10130155B3 Reporter gene construct for the detection of HIV-Rev-Tat and HIV  
The present invention relates to a reporter gene construct for the detection of the HIV rev and HIV-Tat proteins. The invention further relates to a Functionality Test method for recombinantly...
DE10248361A1 Method for suppressing the male sex in birds, specifically in laying poultry, by inserting a lethal DNA sequence into sex chromosomes that is active only in male embryos  
A method for suppressing the male sex in birds by altering the sex chromosomes, is new. Method for suppressing the male sex in birds by altering the sex chromosomes comprises introducing, into at...
DE10235733A1 Amplifying nucleic acid in animal cells, useful e.g. for gene therapy or vaccination, uses an RNA-dependent, RNA-polymerase of a plant virus  
Amplifying nucleic acid (I) in animal cells by introducing an RNA-dependent RNA polymerase (II) from a plant virus into the cells, is new. Independent claims are also included for the following:...
DE10221344A1 Transgenic rats and their use in animal models for human Huntington's disease as well as nucleic acid constructs, vectors and cells for their generation  
Huntington's disease (HD) is an autosomal dominant inherited progressive neurodegenerative disease from the group of "CAG-repeat" / polyglutamine diseases and imported through a triad of...
DE10211369A1 Screening method for identifying protective substances for the treatment of neurodegenerative and / or ischemic diseases  
The present invention relates to a screening method for identifying protective substances which influence hemoglobin formation in neuronal, myocardial and / or skeletal muscle cells, as well as...
DE10156863A1 New gene transfer vectors, useful e.g. for identifying target epitopes of reactive T cells, contains marker protein linked to promoter inducible in antigen-presenting cells  
The invention relates to a method for assaying epitope-specific T cells and target epitopes of reactive T cells. The present invention further relates to vectors, comprising a first promoter that...
DE10139874A1 Human mater proteins  
Two human MATER proteins and their use for fertility disorders, therapy and diagnosis are described.
DE10150783A1 Splicing as a target to identify new active ingredients  
The present invention relates to new deoxyribonucleic acid (DNA) constructs, vectors and host organisms which contain these DNA constructs and are suitable for use in certain processes to indicate...
DE10148195A1 Non-human animal model to study the development and therapy of organ fibrosis  
The present invention relates to a non-human animal model for studying the development and therapy of organ fibrosis. The animal model comprises a double transgenic, non-human animal capable of...
DE10150984A1 Expressing foreign nucleic acids with the adenoviral E2 late promoter, useful in the treatment of tumors, comprises selective activation by Y-box-binding protein-1 in tumor cell nuclei  
Expressing nucleic acids with adenoviral E2 late promoter (A), or its fragment, other than those genes or nucleic acid normally controlled by (A), comprising activation by Y-box-binding protein-1...
DE10137444A1 RNA amplification system from the plant in animal cells  
The invention relates to a novel system for constitutive or inducible, stable or transient intracellular amplification of foreign RNA in an animal cell or an organism. The system is based on...
DE10128832A1 Vector and its use in gene therapy processes  
The present invention relates to a vector particularly suitable for somatic gene therapy, pharmaceutical compositions containing this vector and uses of the vector.
DE10125839A1 Regulating gene expression and viral replication by switching off an active mutated promoter of a repressor allows selective expression of therapeutic genes and viral vectors in tumor cells  
Regulating gene expression and viral replication by switching off an active mutated promoter of a repressor, where a tumor-specific gene and viral vector is used where the repressor protein has...
DE10117381A1 Production of polyclonal, monospecific antibodies against uPAR variants del4, del5 and del4 + 5 and their use for diagnostic and therapeutic purposes  
The invention relates to the production of specific antibodies to detect human tumour-associated urokinase-type plasminogene activator receptor (uPAR) deletion variants in biological samples and...

Matches 1 - 50 out of 203 1 2 3 4 5 >