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DE212016000236U1 Human endothelin receptor binding antibody and its use  
A specifically binding to human endothelin receptors antibody, characterized in that the antibody comprises one of the following schemes of amino acid sequences: a. CDR3 light chain sequence...
DE112016004398T5 THE ANTIBODIES THAT SPECIFICALLY BIND THE TYPE-1 RECEPTOR OF THE FIBROBLAST GROWTH FACTOR, THE USE OF ANTIBODIES FOR THE TREATMENT OF ONCOLOGICAL DISEASES, A PROCESS FOR THE MANUFACTURE OF THE ANTIBODIES  
The group of inventions relates to biotechnology and medicine and refers to antibodies for the treatment of oncological diseases. The antibodies of the invention specifically bind and block...
DE102011118022B4 Antibodies against the prostate-specific stem cell antigen and its use  
The invention relates to recombinant antibodies that bind to prostate-specific stem cell antigen (PSCA). The antibody according to the invention contains complementarity-determining regions (CDR)...
DE19845436C5 Intaglio printing of contiguous color areas of different ink layer thickness, disk-formed in intaglio print image, printing plate and method for producing a printing plate  
A process for printing a data carrier in intaglio printing with a print image, the at least one first color surface (12a) with a first ink layer thickness (Da) And at least one of the first color...
DE212011100195U9 Antibody that stops or delays tumor growth (variants)  
Monoclonal antibody with a hypervariable 1-3 CDR section according to SEQ ID NO: 1 and / or 2 and / or 3, which has an affinity of at least 2 × 10–9 to domains II and IIIc of fibroblast growth...
DE212011100195U1 Antibody will stop the growth of tumors or delayed (variants)  
A monoclonal antibody having a hypervariable CDR-section 1-3 according to SEQ ID NO: 1 and / or 2 and / or 3, which has an affinity of at least 2 x 109 has to domains II and IIIc of the fibroblast...
DE69132920C5 Method for the production of filamentous bacteriophage antibody-presenting by use of phagemids and the bacteriophage produced Daduchus  
A filamentous bacteriophage particle, on whose surface a binding molecule is presented, which is a Fab or single-chain Fv antibody molecule comprising a binding domain capable of binding to the...
DE112008003232T5 Antigen binding constructs  
An antigen-binding construct consisting of a protein backbone that is associated with one or more epitope binding domains, wherein the antigen-binding construct has at least two antigen binding...
DE202009017108U1 Monoclonal antibody to Microcephalin (MCPH1)  
A monoclonal antibody or fragment thereof, characterized in that it specifically binds to Microcephalin (MCHP1) and recognizes an epitope which is located in the area of ​​amino acids 1 to 267 of...
DE19845436B4 Intaglio printing of contiguous color areas of different ink layer thickness, disk-formed in intaglio print image, printing plate and method for producing a printing plate  
Disk (10) produced in intaglio print image, the at least one first color surface (12a) with a first ink layer thickness (Da) And at least one of the first color surface (12a) adjacent the second...
DE102007001370A1 RNA encoded antibody  
The This application describes an antibody coding, unmodified or modified RNA and their use for the expression of this antibody for the preparation of a pharmaceutical composition, in particular a...
DE10346627A1 Single-chain antibody against the 37 kDa / 67 kDa laminin as tools for diagnosis and therapy of prion diseases and cancer, their preparation and use  
described are single chain antibodies, called. "single-chain" antibodies, specific both the 37 kDa precursor form of the laminin receptor (37 kDa LRP) as well as the 67 kDa high-affinity form of...
DE10303664A1 Recognition molecules for the treatment and detection of tumors  
The invention relates to recognition molecules, which are directed against tumors, pharmaceutical compositions comprising said recognition molecules, method for production of the recognition...
DE10256900A1 Tumor-specific recognition molecules  
The invention relates to recognition molecules, which are directed against tumors and can be used for diagnosis and therapy of tumor diseases.
DE10229906A1 New purified polypeptide (e.g. an antibody) that induces apoptosis of a neoplastic cell, useful for diagnosing or treating a neoplasm or a proliferative disorder in mammals, including humans  
A purified polypeptide that induces apoptosis of a neoplastic cell to which it binds, but does not induce apoptosis of a non-neoplastic cell, is new. The polypeptide specifically binds to at least...
DE10210427A1 Human monoclonal antibody  
A human monoclonal antibody with heavy and light chain molecules is described, each of which has an antibody-to-antibody constant and an antibody-to-antibody-variable region. According to the...
DE10139874A1 Human mater proteins  
Two human MATER proteins and their use for fertility disorders, therapy and diagnosis are described.
DE10143647A1 New DNA sequences encoding antibody variable regions, useful for preparation of polypeptides for treatment, prevention and diagnosis of prion diseases  
A DNA sequence (I) that encodes the variable region of an antibody (Ab) that binds to prion protein (PrP) contains at least one of four fully defined 330 or 324 base pair sequences given in the...
DE10123041A1 New single-chain human antibody fragment, useful for treating or diagnosing hepatitis C virus infection, has affinity for an essential viral protein  
Single-chain fragment (I) of a human antibody that inhibits replication of hepatitis C virus (HCV), and comprises the variable regions (Vl and Vh) of the light and heavy chains of an antibody...
DE10063048A1 Single-chain antibody with improved stability  
Disclosed is a single-chain antibody which is characterized in that the C-terminus of V¶H¶ domain is linked directly without a linker to the N-terminal of V¶L¶ domain, the domain V¶H¶ a deletion...
DE10060140A1 Multimeric multi-antigen-binding single chain antibody  
The invention relates to multimers of single-chain antibodies with multiple antigen binding, in particular cyclic homodimers, the production and use thereof.
DE10041541A1 New nucleic acid encoding moth allergens, related polypeptides and antibodies, useful in the diagnosis and treatment of arthropod allergies  
A nucleic acid (I) encoding an allergenic polypeptide (II), is new. A nucleic acid (I) encoding an allergenic polypeptide (II) comprises: (a) a sequence (1; 1294 bp), (3; 1092 bp), (5; 2230 bp) or...
DE10038722A1 A process for the reduction of specific immune responses  
The invention is based on a reduction of specific immune reactions. In the process of antigen-producing cells for the presentation of defined antigens are initiated with the simultaneous...
DE10037111A1 Producing a recombinant protein in a prokaryotic host cell  
The invention relates to advantageous processes for preparing heterologous proteins in prokaryotic host cells by improved codon use and/or expression of tRNAs which code for codons occurring...
DE10019119A1 New leukotriene Bx receptor gene, LTBx, useful for diagnosis and treatment of LTBx-related diseases  
The human LTBx gene (I) of 5750 bp, including 5' and 3'-untranslated regions, reproduced. (I) overlaps the leukotriene B4 receptor on chromosome 14, strongly implying common transcriptional...
DE10019967A1 New recombinant antibody specific for native gp96, useful for isolating gp96 as complex with endogenous peptides, used for autologous immunotherapy of e.g. tumor  
Recombinant antibody (Ab) that binds native gp96, is new. Independent claims are also included for the following: (1) purifying gp96 by applying a clarified cell lysate to a matrix containing...
DE10027695A1 Vaccines against conformation-dependent or non-peptide antigens, based on DNA encoding peptide which mimics the antigen, useful e.g. as antitumor vaccines  
A vaccine (V1) against conformation-dependent antigens (CDA) comprising DNA (I) and/or an antibody, or peptide which immunologically imitates CDA, is new. A vaccine (V1) against...
DE19930433A1 New tetrameric Fv antibody construct having high affinity for antigen without causing immune reactions, useful for treating tumors and infections  
Tetrameric Fv antibody constructs (I) in which the variable heavy and light (Vh, Vl) domains of the individual monomers are linked through an amino acid (aa). Independent claims are also included...
DE4193302C2 Using recombinant antibody specific for TNF-alpha  
Recombinant, particularly humanized, for example, humanized, chimeric and CDR-grafted humanised antibody molecules having specificity for human TNF-alpha, are intended for use in diagnosis and...
DE19903495A1 Ewing tumor antigen and nucleic acid  
The invention relates to a nucleic acid coding for a polypeptide which is expressed by Ewing's tumours and is detected by antibodies or cytolytic cells as a characteristic antigen of the tumour.
DE19845436A1 Intaglio printing for printing of adjacent areas of color varying ink layer thickness  
The invention relates to a data carrier with a printed image that is produced by means of a gravure process. The printed image comprises at least one first colour surface with a first colour...
DE19846979A1 New human and murine G-coupled receptor EDG (endothelial differentiation gene) 6, useful for modulating inflammatory and immune reactions and for treatment of allergy or tumors  
Human and murine G-coupled receptors EDG (endothelial differentiation gene) 6 (I and II), with the 338 and the 386 amino acid sequences, respectively, both fully defined in the specification, or...
DE19820663A1 Recombinant antibodies  
The invention relates to novel nucleic acid sequences encoding human autoantibodies and antiidiotypic antibodies to platelet membrane proteins, novel amino acid sequences of human antibodies and...
DE19739685A1 Monoclonal antibodies for the therapy and prophylaxis of diseases caused by Cl ostridium difficile  
The invention relates to monoclonal antibodies capable of recognizing and neutralizing epitopes from the ligand domain, the translocation domain or the catalytic domain for the enterotoxin (toxin...
DE19718251A1 Expression of fungicide-binding polypeptides in plants for the production of fungicide tolerance  
The invention relates to a method for producing fungicide-tolerant plants by expressing a fungicide-binding antibody therein.
DE19716892C1 Vector for expressing immunoglobulin-cytokine fusion protein  
Vector for expressing an immunoglobulin (Ig)-cytokine fusion protein (I) in malignant B cells comprises: (a) a region (II) \- 1.5 kb homologous to a region of the mu or kappa intron; (b) at least...
DE19638745A1 Monoclonal antibodies to the extracellular domain of human VEGF - receptor protein (KDR)  
Monoclonal antibodies, secreted by hybridoma cell lines, that are directed against an epitope of the extracellular domain of human VEGF-receptor KDR, methods of determining human VEGF-receptor KDR...
DE19513676A1 Cytoplasmic expression of antibodies, antibody fragments and antibody fragment fusion molecules in E. coli  
The invention relates to the cytoplasmic expression of antibodies, antibody fragments and antibody fragment fusion molecules in E. coli. In particular, antibody fragment fusion molecules with an...
DE19500723A1 New variable domains of antibody recognising cancer specific mucin  
Variable domains of the heavy (H) and light (L) chains of an antibody that recognises a cancer-specific mucin (A) contain the 122 (H) and the 112 (L) amino acid sequences given in the...
DE4326573A1 By exon v5 of the CD44 gene polypeptides encoded as targets for immunotherapy and immunoscintigraphy of tumors  
The present invention relates to means for the therapy and in vivo diagnostics of tumors based on the selective binding of antibodies to epitopes encoded by variant exons of the CD44 gene. The...
DE4225853A1 Granulozytenbindende antibody fragments, their preparation and use  
The present invention describes heavy and light antibody chains with specificity for NCA 95 derived from mouse monoclonal antibody BW 250/183, as well as a method for its production and its use in...
DE4122599C2 Phagemid for screening of antibodies  
A phagemid was constructed which expresses a single chain antibody fused to coliphage pIII protein. The phagemid is suitable for the selection of specific antibodies from large libraries using...
DE4203545A1 Antibodies specific for activated platelets, THEIR PRODUCTION AND THEIR USE IN DIAGNOSIS AND THERAPY  
The invention relates to monoclonal antibodies and portions thereof preferentially binding to active human platelets, the heavy and light chain heavy chain MAK BW 2128 nucleotide and amino acid...
DE4142077A1 METHOD FOR EXPRESSION OF RECOMBINANT ANTIKOERPER  
The present invention relates to a method for producing an immunoglobulin expression vector which allows the expression of immunoglobulin without sequence changes in the coding regions....
DE4122599A1 SURFACES EXPRESSION VECTOR FOR SCREENING OF ANTIBODIES  
A phagemide has been constructed that expresses an antibody merged to coliphage pIII protein. The phagemide is suitable for selecting specific antibodies from large gene banks with small...
DE4118120A1 TETRA VALENTE bispecific RECEPTORS, THEIR PRODUCTION AND USE  
the invention relates to tetravalent bispecific receptors, genetically engineered by fusion of DNA, the heavy chain of an F (ab) '↓ 2 ↓ fragment of an antibody (I) encodes with (a) DNA, which...
DE4122598C1 Recombinant antibodies on the surface of E. coli  
A vector expresses a single chain of antibody variable domains coupled to the peptidoglycane-associated lipoprotein (PAL) of E.coli. Also disclosed are the use of this vector and a process for...
DE4033120A1 Genomic DNA fragment encoding antibody variable region prodn. - by attaching primers to hybridoma DNA then subjecting to polymerase chain reaction, for constructing genes encoding chimeric antibodies  
Isolation of a DNA fragment (I) which encodes the variable region of an antibody (Ab) comprises (1) isolating DNA from a hybridoma cell line which secretes the required Ab; (2) converting the DNA...
DE4018442A1 RECOMBINANT DNA AND METHOD FOR PRODUCING A chimeric antibody  
A recombinant DNA, which codes for the light or heavy chain of an antibody, whose constant regions are of human origin and whose variable regions are not of human origin, has a cDNA sequence...
DE4014510A1 VARIANT CD44 OBERFLAECHENPROTEINE THIS CODING C DNA Sequences, antibodies against these proteins AND THEIR USE IN DIAGNOSIS AND THERAPY  
The invention relates to variant CD44 surface proteins. Antibodies against the variant determinant of these proteins and a process for producing them, and in addition the C-DNA sequences which...

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