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DE102017125888A1 New engineered T cell receptors and their use in immunotherapy  
The present invention relates to antigen-recognizing constructs against COL6A3 antigens. In particular, the invention provides novel engineered T cell receptor (TCR) based molecules which are...
DE102017115966A1 Polypeptide molecule with improved dual specificity  
The present invention relates to a bispecific polypeptide molecule, comprising a first polypeptide chain and a second polypeptide chain, which provide a binding region, derived from a T cell...
DE10113265B4 Use of a stabilized nucleic acid for the production of a protein  
The invention teaches the use of a linear nucleic acid stabilized against exonuclease degradation in a method of producing a protein encoded by a base sequence of the nucleic acid in a cell-free...
DE102011118022B4 Antibodies against the prostate-specific stem cell antigen and its use  
The invention relates to recombinant antibodies that bind to prostate-specific stem cell antigen (PSCA). The antibody according to the invention contains complementarity-determining regions (CDR)...
DE102007063902B3 Aptamers that bind to a target molecule involved in hemostasis  
Aptamer that binds to a target molecule involved in hemostasis, the aptamer being an aptamer that binds to activated protein C, the aptamer having a dissociation constant KD binds to activated...
DE102015009439B4 Triple target HIV-1 NAT for the detection of all known genotypes  
A primer / sample set for the detection of HIV, in particular HIV-1, comprising at least one primer / sample set 1 consisting of oligonucleotides comprising SEQ ID NOs 1, 2 and 3; Primer / sample...
DE102007041476B4 Aptamers that bind to a target molecule involved in hemostasis  
Aptamer that binds to a target molecule involved in hemostasis, the aptamer being a thrombin-binding fusion aptamer, comprising at least two thrombin-binding aptamers and at least one linker, the...
DE19549875B4 Use of magnetic particles to isolate nucleic acids  
Magnetic particles with an outer glass surface that is essentially pore-free or has pores with a diameter of less than 10 nm and ferromagnetic particles with a glass surface can preferably be used...
DE112015001085T5 Antibodies, uses and procedures  
The present invention relates to anti-human OX40L antibodies, new medical uses and methods.
DE102015216558A1 PROCEDURE AND TEST KIT FOR FAST ISOLATION OF NUCLEIC ACIDS BY SMOKE SURFACES  
The invention relates to a method for isolating nucleic acids from nucleic acid-containing samples, characterized in that free nucleic acids released by lysis are bound to a solid phase with a...
DE19858588B4 The dye-labeled oligonucleotide for labeling a nucleic acid molecule  
The dye-labeled oligonucleotide for labeling a a target sequence section comprising a nucleic acid molecule, wherein the dye-labeled oligonucleotide comprises the following components: a) - a loop...
DE102014001464A1 RNAi technology  
Ribonucleic acids (RNAs) can be blocked by small inhibitory RNAs. In this way, genes off. This mechanism known as RNA interference was first described by Andrew Fire and Craig Mello. For the...
DE102013111487A1 The bispecific antibody fragment and pharmaceutical combination preparation with such a  
The invention relates to a bispecific antibody fragment (10) with a first detection point (12) and at least a second detection point (14), which specifically recognize each at least one structure...
DE102013006487A9 Iterative assembly and disassembly of predetermined, artificial DNA constructs and the specific exchange of functional genetic elements  
A variety of assembly methods for higher-order DNA constructs for the integration of molecular function have been described and also patented. There are no uniform concepts for the targeted...
DE102013105144A1 The pharmaceutical combination product with an anti-idiotype antibody fragment  
The invention relates to a pharmaceutical combination preparation (10), in particular to suppression of an immune response, preferably a humoral immune response against a therapeutic organism...
DE112004000265B4 Novel photolabile protecting groups for improved processes for the production of oligonucleotide arrays  
Use of a compound having the general formula (1): in which R1 Is COOY, where Y is selected from the group consisting of an optionally substituted alkyl group having up to 10 carbon atoms on the...
DE102013006487A1 Iterative assembly and disassembly of predetermined, artificial DNA constructs and the specific exchange of functional genetic elements  
A variety of assembly methods for higher-order DNA constructs for the integration of molecular function have been described and also patented. There are no uniform concepts for the targeted...
DE102012110664A1 In coatings, bonding agents or adhesives for oxide surfaces usable peptides  
The present invention relates to peptides, particularly dodecapeptides containing coating agents, adhesion promoters or adhesives for oxide surfaces, a multilayer composite or a coated substrate...
DE102012103730A1 Detection method for Mycobacterium avium ssp. paratuberculosis  
The present application relates to a method for the specific detection and optionally quantification of Mycobacterium avium ssp. paratuberculosis (MAP) in a sample of an individual. According to...
DE102011120550B4 Compositions, methods and kits for the detection of adenovirus nucleic acids  
A method for specifically detecting an adenovirus target nucleic acid in a sample, comprising the steps: (a) contacting a sample suspected of containing at least one adenovirus nucleic acid with...
DE102008025328B4 Compositions and methods for the amplification of HI viruses by means of multiplex-PCR in multiple genome areas  
A method of detecting HIV-1 and HIV-2 in blood-derived samples, comprising a) providing samples derived from blood, b) concentrating the blood-derived samples, c) extracting the viral nucleic...
DE102012101557A1 Use of microRNAs or genes as markers for the identification, diagnosis and therapy of individual non-ischemic cardiomyopathies or memory diseases of the heart  
The invention relates to the use of certain microRNAs and / or genes both individually and in combination in the form of profiles as markers for the identification of individual non-ischemic...
DE102007010252B4 Control genes for normalizing gene expression analysis data  
Control gene set for the normalization of gene expression analysis data from blood samples of a patient with diseases with a systemic immune reaction, in particular SIRS, sepsis, severe sepsis,...
DE102011121238A1 SINGLE DOMAIN ANTIBODIES AGAINST CLOSTRIDIUM DIFFICILE TOXINE  
The invention relates to antigen-binding polypeptides which comprise the CDR1, CDR2 and CDR3 region of a VHH domain of a camelide heavy chain antibody. The polypeptides bind specifically in the...
DE102006020463B4 A method of removing nucleic acids from a fluid, method for producing adsorber and using Membranadsorbermaterial-blend  
A method for at least partial removal of nucleic acids (18) from a liquid (12), as they occur during the digestion of microorganisms such as bacteria, yeasts, fungi, protozoa or eukaryotic cell...
DE69132920C5 Method for the production of filamentous bacteriophage antibody-presenting by use of phagemids and the bacteriophage produced Daduchus  
A filamentous bacteriophage particle, on whose surface a binding molecule is presented, which is a Fab or single-chain Fv antibody molecule comprising a binding domain capable of binding to the...
DE4321904B4 A process for chromatographic purification and separation of Nucleinsäuregemischen  
A process for chromatographic purification and separation of Nucleinsäuregemischen from biological sources such as cell cultures, tissues, body fluids, microorganisms or viruses to be separated by...
DE102011055247A1 Multianalyt reporter system  
The invention relates to a mediator probe for binding to a target molecule and / or a detection molecule comprising a probe region and a mediator-region as well as a method for detecting at least...
DE102011054413A1 Anti-idiotype monoclonal antibody ganglidiomab  
The present invention relates to an anti-idiotypic antibody that mimics the disialoganglioside GD2. GD2 is expressed on neuroectodermal tumors. Also included is a corresponding hybridoma cell line...
DE102011107197A1 Use of a crosslinked sulfonated polymer to separate macromolecules from a solution derived from a biological source, where the crosslinked sulfonated polymer is optionally bonded to a scaffolding containing a sulfonated aryl moiety  
Use of a crosslinked sulfonated polymer for the separation of macromolecules from a solution derived from a biological source, is claimed, where the crosslinked sulfonated polymer is optionally...
DE102011118022A1 Antibodies to the prostate specific antigen stem cells and the use thereof  
The invention relates to recombinant to prostate-specific stem cell antigen (PSCA) antibody binding. The antibody of the invention comprises complementarity determining regions (CDR) having the...
DE102011056606B3 Method for the electrochemical detection of nucleic acid oligomer hybridization events  
A method for the electrochemical detection of nucleic acid oligomer hybridization events comprising the steps is described a) providing a modified surface, the modification consisting in the...
DE602004036672C5 Nucleic acid-based emulsion beads  
Method for enriching an amplicon comprising: (A) distributing an amplification solution, which comprises a sufficient mixture of reagents that are required for carrying out an amplification...
DE102012008759A1 Nucleoside-triphosphate conjugates and methods of using them  
The invention describes a new method for the enzymatic labeling of nucleic acid chains (target sequences) with nucleotide conjugates. These nucleotide conjugates are able to bind to a target...
DE10352433B4 Polypeptide a Silicatein ß from Suberites domuncula, nucleic acid coding therefor, their uses, this nucleic acid vector comprising and expressing this polypeptide host cell  
Polypeptide a Silicatein β from Suberites domuncula according to SEQ ID NO. 1, recombinant polypeptide comprising an amino acid sequence of β-Silicatein domain identical to the sequence shown in...
DE112010004821T5 Processing of amplified DNA fragments for sequencing  
A processing method for trimming the ends of DNA fragments to expose the inner DNA portion for forwarding the original DNA sequence information that allows the application of next generation...
DE102011009470A1 Biologically active nucleotide molecules for targeted cell killing, use of the same and application kit  
The task was to kill cells in a wide range of applications, effectively, reliably and as effectively as possible in the organism, without the above-mentioned disadvantages of known chemical,...
DE10113776B4 Isolated streptavidin-binding, competitively elutable peptide, this comprehensive fusion peptide, nucleic acid coding therefor, expression vector, method for producing a recombinant fusion protein and method for detecting and / or obtaining the fusion protein  
Isolated streptavidin-binding, competitively elutable peptide, comprising at least two streptavidin-binding individual modules, the distance between the two individual modules being 0 and a...
DE102011006610B3 Aptamers that are specific for immunoglobulin binding cell wall proteins  
The invention relates to an aptamer which binds to substances containing protein A, G or L, protein A, G or L and to microorganisms containing protein A, G or L, in particular Staphylococcus...
DE10237517B4 A process for the enrichment or depletion of biomolecules from liquid or fluid media using Schichtdoppelhydroxiden and use of other on a layered double hydroxide or incorporated biomolecules as inorganic Vector  
A process for the removal or recovery or purification of at least one biomolecule, which contains, as building blocks nucleotides, nucleosides, amino acids, monosaccharides and / or fatty acids...
DE102011006612B3 Aminoglycoside-specific aptamers  
The invention relates to aptamers that bind to one or more compounds from the group of aminoglycosides, uses of the aptamers and methods for the detection and enrichment of compounds from the...
DE102009013748B4 Determination of interactions constant antibody portions with Fc gamma receptors  
A recombinant expression vector comprising sequences for the recombinant expression of at least one fusion protein on the surface of a mammalian cell comprising a) an extracellular portion of a...
DE102009024757B4 Methods and devices for controlling a chemical reaction using pressure using high-pressure-optimized biocomponents  
Method for controlling a chemical reaction by means of pressure using high-pressure-optimized biocomponents, a combination of high-pressure-optimized and low-pressure-optimized biocomponents,...
DE102008063592B4 Multifunctional laboratory process bags for the clean production of biomolecules  
Process for as many times repeatable providing subsets purified biomolecules or Biologicals a whole the same clonal origin for quality tests or functional tests with steps a) introducing at least...
DE202011103324U1 Therapeutic anti-TIRC7 antibody for use in immune and other diseases  
Monoclonal antibody or antigen-binding molecule which is able to bind to an antigen comprising or consisting of the amino acid sequence of one of the SEQ ID NOs: 9 to 11.
DE102009044085A1 Procedure for in vitro detection and differentiation of pathophysiological conditions  
The present invention relates to the use of defined polynucleotides for the formation of at least one multi-gene marker for the production of a multiplex assay as an aid for in vitro detection and...
DE102010010052A1 Signaling binding molecules, devices, and methods of use thereof  
The invention relates to signaling binding molecules, also referred to as the sensor-actuator molecules, as well as devices and methods for their use. The sensor-actuator molecules comprise at...
DE102010007548A1 Microarray consisting of spots, at which mixture of polymerase and sequence specific primers is immobilized and coated with substrate, in which enzyme enabling sequence specific amplification is added, useful to genotype and quantify DNA  
Microarray consisting of spots, at which a mixture of polymerase and sequence-specific primers is immobilized using a method and is additionally coated with a precipitation efficient substrate, in...
DE102010007097A1 Conjugates from [F-18] carriers with bioactive, organic compounds and their representation  
The present invention relates to novel chemical compounds that are used under particularly mild conditions 18Can be F-fluorinated. In this way, they enable the use of a novel fluorination process...
DE102006022569B4 Species-independent detection method for biological material  
Use of at least one first primer for DNA fingerprint analysis, wherein the at least first primer contains a sequence derived from an 8 bp palindromic or GC rich sequence, wherein 5 'to the...