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DE102011018627B4 Modified nucleotides  
Connection with structure (I): or a salt, a conjugate base, a tautomer or a dissociated form thereof, wherein P1 is a phosphate group; P2 is a phosphate group; Nus is a nucleoside structural unit...
DE19854973B4 A method for purifying nucleic acids  
Preparation comprising particles having a glass surface, which contains more than 75th% of these particles have a particle size between 0.5 and 15 microns have characterized in that the glass...
DE20122767U1 Massive parallel method for decoding DNA and RNA  
On Nucleotide analogue which comprises: a) a base selected from the group consisting of adenine or an analogue of adenine, Cytosine or an analogue of cytosine, guanine or an analogue of Guanine,...
DE10152376B4 Fluorescent phospholipase A2-samples and their membrane-permeable derivatives  
Phospholipasesubstrat of the general formula I wherein each A independently an alkylene or alkenylene group, branched or unbranched, having 1 to 20 carbon atoms, R1 and R2 each a different...
DE29825173U1 Fludarabine phosphate purification by precipitation from aqueous acetone as stable metal salt, useful as cytotoxic drug  
Fludarabine phosphate (FAP) is purified by treating an aqueous solution of crude FAP with base, precipitating the obtained metal salt (I) of FAP with acetone and treating (I) with acid....
DE10120797B4 A process for the analysis of nucleic acid chains  
process for highly parallel sequence analysis of nucleic acid sequences or nucleic acid chains (NACs), in which Fragments (NACFs) single NACs with a length produced from about 50 to 1000...
DE102004009977A1 New nucleic acid containing fluorescent tricyclic heterocyclic residue, useful as hybridization probes for detection and quantification of nucleic acids  
Nucleic acid (A) comprising a backbone to which at least one tricyclic heterocyclic group (I) is attached is new. Nucleic acid (A) comprising a backbone to which at least one tricyclic...
DE10356837A1 New conjugates useful for modifying nucleic acid chains comprise nucleotide or nucleoside molecules coupled to a label through water-soluble polymer linkers  
Conjugates (I) comprising 1-100 nucleotide or nucleoside molecules coupled to a label through water-soluble polymer linkers are new. Nucleotide or nucleoside conjugates of formula (I) are new:...
DE10303973A1 A method for detection of fertility enhancing or contraceptive agents  
The present invention relates to a method for the detection of changes of cellular messengers in sperms in a stopped-flow measurement apparatus or detecting the motility or the change in swimming...
DE10214395A1 Parallel sequencing of nucleic acid segments, useful for detecting single-nucleotide polymorphisms, by single-base extensions with labeled nucleotide  
Parallel sequence analysis of segments of a complete nucleic acid sequence, using sequence-specific primers, is new. Parallel sequence analysis of segments of a complete nucleic acid sequence,...
DE10152376A1 New substrates for phospholipase, useful e.g. for diagnosis and drug screening, contain two fluorophores that make a fluorescent energy-transfer pair  
Phospholipase substrates (I) containing two fluorophores are new. Phospholipase substrates of formula (I) are new. A = 1-20C alkylene or alkenylene; B = NH, NHCO, CONH, NHCONH, NHCSNH, oxygen or...
DE10132025A1 Stepwise synthesis of biopolymers, useful e.g. for preparing DNA chips, using synthons containing protecting group that requires photoactivation before cleavage  
Stepwise synthesis of biopolymers (A) using protected synthons (B) where at least one (B) carries a two-stage protecting group (PG). PG is activated in a light-irradiation step and cleaved in a...
DE10120797A1 A process for the analysis of nucleic acid chains  
The invention relates to a method for the analysis of nucleic acid chains. Basis of the method is the detection of fluorescence signals of individual, labeled with dyes nucleotide molecules, which...
DE10105079A1 Photolabile protecting groups for the synthesis of biopolymers  
The invention relates to photolabile protective groups for the synthesis of biopolymers, particularly nucleic acids.
DE10105077A1 Hybrid-protecting group  
The invention relates to photo-labile hybrid protecting groups and the application thereof in the synthesis of protected synthons for the light-controlled synthesis of biopolymers, in particular...
DE10024308C1 Purification of 3'-phosphoadenosine-5'-phosphosulfate, for use in determination of sulfotransferase activity, comprises ion exchange chromatography on a supported, functionalized acrylamide hydrogel  
The purification and/or concentration of 3'-phosphoadenosine-5'-phosphosulfate (PAPS) by ion exchange chromatography performed using an acrylamide hydrogel having quaternary ammonium functions,...
DE10021256A1 New Photolabile coumarinylmethyl esters of cyclic nucleotides, processes for their preparation and their use  
The invention relates to novel, photo-labile cumarinylmethyl esters of cyclic nucleotides of general formula (I): axial isomer (Ia), equatorial isomer (Ib); wherein R<1> represents hydrogen,...
DE10010118A1 Coating system, useful for the production of microelectronics, comprises a pyranosyl nucleic acid comprises a pyranosephosphate back bone bonded to purine or pyrimidine bases.  
A coating system, based on pyranosyl-nucleic acids for the formation of adhesion compounds, comprises at least two coating agents (A) containing a pyranosyl nucleic acid and (B) containing other...
DE19952113A1 Nucleoside derivatives having photolabile protecting groups  
The invention relates to nucleoside derivatives with photolabile protecting groups of general formula (I), where R<1> = H, F, Cl, Br, I, NO2; R<2> = H, CN, where R<1> and R<2> are not...
DE19915867A1 New nucleoside derivatives with photolabile protecting groups, useful in oligonucleotide synthesis, particularly on solid phases, e.g. for hybridization testing  
New nucleoside derivatives (I) with photolabile protecting groups. Nucleoside derivatives of formula (I) are new: R<1>-R<4> and R<7> = H, NO2, CN, halo, 1-4C alkyl, alkoxy or alkoxyalkoxy,...
DE19904795A1 Nucleic acid molecules for identifying particular bacteria, used to detect pathogens in foods, are specific for Bacillus cereus and B. thuringiensis  
One or more nucleic acid molecules (I) that are obtained from: (i) a group of bacteria that are to be detected, i.e. representatives of the species Bacillus cereus and B. thuringiensis, or these...
DE19856796A1 Cleavage of chemically synthesized oligo / polynucleotides at a predetermined site  
The invention relates to an oligonucleotide/polynucleotide characterized by the general formula A[-X-B]n, where n is 1 or an integer multiple of 1 and A and B represent identical or different...
DE19855963A1 Amphiphilic glyceryl, processes for their preparation and their use  
The invention relates to glyceryl nucleotides of formula (Ia), wherein a) one of the radicals A<1>, A<2> and A<3> represents a hydrogen atom, or a radical selected among hydroxyl, mecapto, alkyl,...
DE19855259A1 Composition comprising magnetic particles with glass coating, useful for purifying nucleic acids in diagnostic samples  
A composition comprises particles with a glass surface, where more than 75 % of the particles have a diameter of 0.5-15 mu m. A composition is claimed which comprises particles with a glass...
DE19854973A1 Process for the purification of nucleic acids uses glass particles with zinc oxide  
A composition (I) comprises particles with a glass surface and where more than 75 weight % (wt.%) of the particles have a diameter of 0.5-15.0 mu m. Independent claims are also included for the...
DE19850433A1 New coenzyme A derivatives useful for the synthesis of L(-)-carnitine and gamma-butyrobetaine  
Crotonobetainyl-coenzyme A and psi -butyrobetainyl-coenzyme A as characterized by various physical properties are claimed as well as their use in the activation of L-(-)-carnitine dehydratase, the...
DE19850426A1 New gamma-butyrobetainyl-coenzyme A, useful for activating L(-)-carnitine dehydratase, especially for preparing L(-)-carnitine from crotonobetaine  
psi -Butyrobetainyl-coenzyme A (I) is new. psi -Butyrobetainyl-coenzyme A (I) having the following characteristics is new: molecular weight 895.2; absorption maxima at 206 and 258 nm; molar...
DE19837387A1 New nucleic acid analogs useful in therapeutic or diagnostic agents or electronic components, consist of 3'-deoxypentopyranosyl nucleosides  
Nucleic acid analogs (I) consisting of 3'-deoxypentopyranosyl nucleosides are new. Nucleic acid analogs (I) consisting of 3'-deoxypentopyranosyl nucleosides of formula (Ia) or (Ib) are new: R<1>,...
DE19928591A1 Production of polymers from nucleotide and/or non-nucleotide units using RNA ligase, useful for  
An RNA ligase is used in a process for producing polymers from nucleotide and/or non-nucleotide units by coupling in the 3' to 5' direction. Independent claims are also included for the following:...
DE19815864A1 5'-modified nucleotides and their use in molecular biology and medicine  
The invention relates to 5'-modified nucleotides and nucleic acids containing said nucleotides. The invention also relates to methods for integrating 5'-modified nucleotides in nucleic acids and...
DE19812162A1 Nucleotidaktivierte di- and oligosaccharides, as well as processes for their preparation I  
The invention relates to a method for the production of nucleotide activated disaccharides and oligosaccharides with n saccharide units, whereby a nucleoside diphosphate sugar (NDP sugar) is...
DE19812156A1 Nucleotidaktivierte di- and oligosaccharides, as well as processes for their preparation II  
The invention relates to nucleotide activated disaccharides and oligosaccharides and to a method for the production thereof. According to the invention, a sugar which is substituted on the...
DE19750508A1 New phospholipid-nucleoside adducts useful for treating and preventing mammary tumors and leukemia  
Phospholipid-nucleoside adducts (I) are new. Phospholipid-nucleoside adducts of formula (I) are new. R = 4-22C hydrocarbon group which is saturated or unsaturated and may be substituted by one or...
DE19741738A1 Linker nucleoside(s) containing alkenyloxy or phthalimido-alkyl groups  
Linker nucleosides of formula (I)-(IV) are new: R1 = H, OH or halogen (preferably Br or Cl); R2-R4 = 2-12C alkenyloxy or phthalimido(1-12C)alkyl, where phthalimido is optionally substituted by 1-4...
DE19741715A1 New pentopyranosyl nucleoside compounds  
Pentopyranosyl nucleosides of formula (I) and (II) are new. : R1 = H, OH or halogen; R2-R4 = H, NR5R6, OR7, SR8, oxo, 1-12C alkyl or (CnH2n)R10R11; n = 1-12; R10, R11 = H or 1-12C alkyl, or...
DE19712530A1 New monomer to label peptide nucleic acids  
The invention relates to novel monomers elements for marking peptidic nucleic acids and similarly structured nucleic acid-binding oligomers with groups which are coupled to a nucleo-base or/and...
DE19647055A1 The stabilized aqueous solutions nucleoside triphosphate  
The invention relates to stable aqueous solutions containing one or more nucleoside triphosphates, wherein each solution has a pH value higher than 7.5 and no additional stabilizing substances....
DE19640974A1 Building blocks for DNA / PNA-co-oligomers  
The invention relates to compounds of the general formula (I) ## STR5 ## in which the substituents have the meanings given in the description. ## STR5 ## The compounds are suitable for the...
DE19640054A1 Di:nucleotide(s) with modified base, sugar and phosphate groups  
Dinucleotides with modified base, sugar and phosphate groups of formula (I) are new. R1, R6 = NH2, N3, OMe, allyl, OH, H or F; R2, R5 = O or NH; provided that when R5 is NH then R2 is not NH; and...
DE19628171A1 Apparatus for enriching charged molecules, especially nucleic acids or proteins  
Apparatus for enriching charged molecules comprises: (a) a container for receiving a solution containing the charged molecules; (b) \- 1 insert with a surface that can contact the solution and is...
DE19627898A1 Solid phase synthesis of oligonucleotides  
The invention therefore provides a process for the preparation of oligonucleotides by means of solid-phase synthesis by $ A a) sequential construction of the nucleotides on a solid support...
DE19627032A1 Non-radioactively labelling nucleoside-3'-phosphate  
Preparation of a non-radioactively labelled nucleoside-3'-phosphate (I), from a nucleoside-3'-phosphate (II) containing a nucleo-base, a pentose and a phosphate group, comprises: (a) coupling (II)...
DE19618727A1 Preparation of alkylated nucleoside-3'-phosphates  
The invention concerns a process for producing an alkylated nucleoside-3'-phosphate having a nucleobase, a pentose and a phosphate group, consisting of the following steps: (a) reaction of...
DE19543052A1 Purifying fludarabine phosphate  
Preparation and purification of fludarabine phosphate (I) from 9- beta -D-arabinofuranosyl-2-fluoroadenine, trimethyl phosphate and phosphorous oxychloride, comprises recrystallisation of the...
DE19529025A1 New 8-bromo-substituted cyclic Nucleotidester, processes for their preparation and their use  
The invention concerns photolabile 8-substituted guanosine-3',5'-cyclomonophosphate esters and 8-substituted adenosine-3',5'-cyclomonophosphate esters of formula (I) and methods of preparing these...
DE19611376A1 Nucleic acid cpds. contg. non-nucleic acid ring skeleton, pref. tri:terpenoid  
New nucleic acid cpds. contg. a non-nucleic acid ring skeleton to which two functional gps. are bound at a fixed distance and which also point in essentially the same direction, and attached to...
DE4444996A1 Nucleoside derivatives having photolabile protecting groups  
The invention concerns nucleoside derivatives with photolabile protective groups of general formula (I), in which R<1> is H, NO2, CN, OCH3, halogen or alkyl or alkoxyalkyl with 1 to 4 carbon...
DE19518278A1 Lipid-cleaving enzyme  
A membranous enzyme not yet described in the state-of-the-art can be extracted from cellular membrane fractions of blood leukocytes or monocytes/macrophages. Also disclosed is the use of...
DE4438918A1 Modified oligonucleotides, their preparation and their use  
The invention relates to novel modified oligonucleotides having at least one substituted 7-deazapurine base and forming more stable hybridization complexes with nucleic acids, the use thereof as...
DE19518216A1 New ß-L-nucleosides and their use  
The invention relates to novel beta -L-pyrimidine and beta -L-purine nucleosides and their use as pharmaceutical active substances and agents for the prophylaxis and/or treatment of infections...

Matches 1 - 50 out of 92 1 2 >