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DE102011018627B4 Modified nucleotides  
Connection with structure (I): or a salt, a conjugate base, a tautomer or a dissociated form thereof, wherein P1 is a phosphate group; P2 is a phosphate group; Nus is a nucleoside structural unit...
DE202008018643U1 Nucleoside phosphoramidate drugs  
Compound according to the following formula: in which (a) R1 Is hydrogen, methyl, ethyl, n-propyl, i-propyl or a substituted or unsubstituted phenyl, the substituent of the substituted phenyl...
DE102006037786A1 Nucleosides, containing these drugs and their use  
The Invention relates to specific nucleosides, and drugs which these nucleosides contained. Furthermore, the invention relates to the Use of such nucleosides for the preparation of a medicament,...
DE20122767U1 Massive parallel method for decoding DNA and RNA  
On Nucleotide analogue which comprises: a) a base selected from the group consisting of adenine or an analogue of adenine, Cytosine or an analogue of cytosine, guanine or an analogue of Guanine,...
DE102004051804A1 Beta-L-N4-hydroxycytosine-deoxynucleosides and their use as pharmaceutical agents for the prophylaxis or therapy of viral diseases  
The Invention relates to β-L-N4-hydroxycytosine nucleosides and pharmaceutical compositions comprising them and the use of the β-L-N4-hydroxycytosine nucleosides and the pharmaceutical agent for...
DE10120797B4 A process for the analysis of nucleic acid chains  
process for highly parallel sequence analysis of nucleic acid sequences or nucleic acid chains (NACs), in which Fragments (NACFs) single NACs with a length produced from about 50 to 1000...
DE10356837A1 New conjugates useful for modifying nucleic acid chains comprise nucleotide or nucleoside molecules coupled to a label through water-soluble polymer linkers  
Conjugates (I) comprising 1-100 nucleotide or nucleoside molecules coupled to a label through water-soluble polymer linkers are new. Nucleotide or nucleoside conjugates of formula (I) are new:...
DE10214395A1 Parallel sequencing of nucleic acid segments, useful for detecting single-nucleotide polymorphisms, by single-base extensions with labeled nucleotide  
Parallel sequence analysis of segments of a complete nucleic acid sequence, using sequence-specific primers, is new. Parallel sequence analysis of segments of a complete nucleic acid sequence,...
DE10209564A1 Antitumoral and antineoplastic medicaments, effective against carcinoma, sarcoma, lymphoma and leukemia, comprise new or known nucleoside-sulfur containing phospholipid derivatives  
Nucleoside-sulfur containing phospholipid derivatives (I), which on adminstration to humans directly or indirectly provide (I) or other antitumoral or antiproliferative active metabolites or their...
DE10156910A1 Antitumoral and antineoplastic medicaments, effective against carcinoma, sarcoma, lymphoma and leukemia, comprise new or known nucleoside-sulfur containing phospholipid derivatives  
Nucleoside-sulfur containing phospholipid derivatives (I), which on adminstration to humans directly or indirectly provide (I) or other antitumoral or antiproliferative active metabolites or their...
DE10132025A1 Stepwise synthesis of biopolymers, useful e.g. for preparing DNA chips, using synthons containing protecting group that requires photoactivation before cleavage  
Stepwise synthesis of biopolymers (A) using protected synthons (B) where at least one (B) carries a two-stage protecting group (PG). PG is activated in a light-irradiation step and cleaved in a...
DE10120797A1 A process for the analysis of nucleic acid chains  
The invention relates to a method for the analysis of nucleic acid chains. Basis of the method is the detection of fluorescence signals of individual, labeled with dyes nucleotide molecules, which...
DE10201458A1 New proteins involved in isoprenoid biosynthesis, useful in screening for inhibitors, also new intermediates, potential therapeutic agents, nucleic acids and antibodies  
A protein (P1) capable of enzymatic conversion of 2C-methyl-D-erythritol-2,4-cyclodiphosphate (I) to 1-hydroxy-2-methyl-2-butenyl-4-diphosphate (II), especially the (E) form, is new. Independent...
DE10108851A1 Use of 5'-substituted nucleosides and / or their prodrugs for the resistance-free therapy of infectious diseases  
The invention relates to the use of 5-substituted nucleosides and/or prodrugs thereof together with at least one active substance in order to produce a medicament or combination preparation used...
DE10105079A1 Photolabile protecting groups for the synthesis of biopolymers  
The invention relates to photolabile protective groups for the synthesis of biopolymers, particularly nucleic acids.
DE10105077A1 Hybrid-protecting group  
The invention relates to photo-labile hybrid protecting groups and the application thereof in the synthesis of protected synthons for the light-controlled synthesis of biopolymers, in particular...
DE19952113A1 Nucleoside derivatives having photolabile protecting groups  
The invention relates to nucleoside derivatives with photolabile protecting groups of general formula (I), where R<1> = H, F, Cl, Br, I, NO2; R<2> = H, CN, where R<1> and R<2> are not...
DE19915867A1 New nucleoside derivatives with photolabile protecting groups, useful in oligonucleotide synthesis, particularly on solid phases, e.g. for hybridization testing  
New nucleoside derivatives (I) with photolabile protecting groups. Nucleoside derivatives of formula (I) are new: R<1>-R<4> and R<7> = H, NO2, CN, halo, 1-4C alkyl, alkoxy or alkoxyalkoxy,...
DE19855963A1 Amphiphilic glyceryl, processes for their preparation and their use  
The invention relates to glyceryl nucleotides of formula (Ia), wherein a) one of the radicals A<1>, A<2> and A<3> represents a hydrogen atom, or a radical selected among hydroxyl, mecapto, alkyl,...
DE19837387A1 New nucleic acid analogs useful in therapeutic or diagnostic agents or electronic components, consist of 3'-deoxypentopyranosyl nucleosides  
Nucleic acid analogs (I) consisting of 3'-deoxypentopyranosyl nucleosides are new. Nucleic acid analogs (I) consisting of 3'-deoxypentopyranosyl nucleosides of formula (Ia) or (Ib) are new: R<1>,...
DE19913206A1 Production of CMP-sialate synthetase protein useful for producing CMP-activated N-acetylneuraminic acid analogs and non-naturally sialylated oligosaccharides and glycoconjugates  
The production of a CMP (cytidine monophosphate)-sialate synthetase protein is new and comprises culturing a prokaryotic host organism transformed with an expression vector containing a structural...
DE19812162A1 Nucleotidaktivierte di- and oligosaccharides, as well as processes for their preparation I  
The invention relates to a method for the production of nucleotide activated disaccharides and oligosaccharides with n saccharide units, whereby a nucleoside diphosphate sugar (NDP sugar) is...
DE19812156A1 Nucleotidaktivierte di- and oligosaccharides, as well as processes for their preparation II  
The invention relates to nucleotide activated disaccharides and oligosaccharides and to a method for the production thereof. According to the invention, a sugar which is substituted on the...
DE19647055A1 The stabilized aqueous solutions nucleoside triphosphate  
The invention relates to stable aqueous solutions containing one or more nucleoside triphosphates, wherein each solution has a pH value higher than 7.5 and no additional stabilizing substances....
DE19640974A1 Building blocks for DNA / PNA-co-oligomers  
The invention relates to compounds of the general formula (I) ## STR5 ## in which the substituents have the meanings given in the description. ## STR5 ## The compounds are suitable for the...
DE19640054A1 Di:nucleotide(s) with modified base, sugar and phosphate groups  
Dinucleotides with modified base, sugar and phosphate groups of formula (I) are new. R1, R6 = NH2, N3, OMe, allyl, OH, H or F; R2, R5 = O or NH; provided that when R5 is NH then R2 is not NH; and...
DE19627898A1 Solid phase synthesis of oligonucleotides  
The invention therefore provides a process for the preparation of oligonucleotides by means of solid-phase synthesis by $ A a) sequential construction of the nucleotides on a solid support...
DE19627032A1 Non-radioactively labelling nucleoside-3'-phosphate  
Preparation of a non-radioactively labelled nucleoside-3'-phosphate (I), from a nucleoside-3'-phosphate (II) containing a nucleo-base, a pentose and a phosphate group, comprises: (a) coupling (II)...
DE19618727A1 Preparation of alkylated nucleoside-3'-phosphates  
The invention concerns a process for producing an alkylated nucleoside-3'-phosphate having a nucleobase, a pentose and a phosphate group, consisting of the following steps: (a) reaction of...
DE19611376A1 Nucleic acid cpds. contg. non-nucleic acid ring skeleton, pref. tri:terpenoid  
New nucleic acid cpds. contg. a non-nucleic acid ring skeleton to which two functional gps. are bound at a fixed distance and which also point in essentially the same direction, and attached to...
DE19533093C1 New conjugate of metallocene with phosphor-amidite  
The invention concerns metallocene-phosphoramidite conjugates comprising one or a plurality of metallocenes and one or a plurality of phosphoramidites. The invention further concerns a process for...
DE19505168A1 Specific lipid conjugates of nucleoside diphosphonates and their use as medicaments  
The invention pertains to novel phospholipid derivatives of nucleosides of the general formula (I), wherein R<1> is an optionally mono- or polysubstituted, straight-chain or branched, saturated or...
DE4444996A1 Nucleoside derivatives having photolabile protecting groups  
The invention concerns nucleoside derivatives with photolabile protective groups of general formula (I), in which R<1> is H, NO2, CN, OCH3, halogen or alkyl or alkoxyalkyl with 1 to 4 carbon...
DE19518278A1 Lipid-cleaving enzyme  
A membranous enzyme not yet described in the state-of-the-art can be extracted from cellular membrane fractions of blood leukocytes or monocytes/macrophages. Also disclosed is the use of...
DE19518216A1 New ß-L-nucleosides and their use  
The invention relates to novel beta -L-pyrimidine and beta -L-purine nucleosides and their use as pharmaceutical active substances and agents for the prophylaxis and/or treatment of infections...
DE4431280A1 A process for the isolation and purification of sugars from biological sources nukleotidaktivierten  
The present invention relates to an improved process for the isolation and purification of sugar nucleotides, in particular cytidine monophosphate-activated N-acetyl-neuraminic acid (CMP-Nana),...
DE4418690A1 Nucleoside 5'-mono-phosphate ester(s) of glyceryl di:ether derivs.  
Nucleoside 5'-monophosphate esters of glyceryl diether derivs. of formula (I), their salts, tautomers, optically active forms, and racemic mixts., are new: R1 = 1-20C satd. or unsatd. alkyl chain,...
DE4402492A1 A process for the preparation of unsymmetrical phosphoric diesters  
The method proposed is characterized in that a phosphoric acid ester is condensed with a hydroxy-group-containing compound in the presence of an aryl sulphonic acid chloride and an organic base....
DE4400310A1 New nucleoside-lipid adducts, their preparation and their pharmaceutical use  
The invention relates to novel nucleoside-lipid adducts of the general formula I, including all enantiomeric forms and all pharmaceutically usable salts of these compounds. Areas of application...
DE4341161A1 Continuous membrane drug to disrupt the DNA biosynthesis  
The invention relates to an active substance which is essentially the same effect on the dUTP in its interactions with the enzyme dUTPase.
DE4325317A1 A method for radiolabeling immunoglobulin  
The invention relates to a method for labeling immunoglobulins, in particular monoclonal antibodies, or their fragments with radioactive nuclides, which are used in medicine, preferably in nuclear...
DE4326466A1 Infrared dye-labeled nucleotides and their use in nucleic acid detection  
Nucleoside 5'-triphosphates and phosphoramidites, which at the base part or on the phosphorus atom, a long-wave absorbing radical, preferably carry a carbocyanine group of general formula (I) $...
DE4321978A1 Liponucleotide of deoxynucleosides, their preparation and their use as antiviral drugs  
The present invention relates to novel phospholipid derivatives of deoxynucleosides which link a lipid moiety, which is a substituted C ↓ 3 ↓ backbone, with a deoxynucleoside via a phosphate or...
DE4344742A1 A process for the immobilization of nucleic acids  
A method for the immobilization of nucleic acids by hybridization of the nucleic acid with a capture probe, wherein the capture probe is protected against enzymatic extension and / or enzymatic...
DE4320570A1 Nucleosides, their preparation and their use as therapeutic agents and as building blocks for synthetic oligonucleotides  
The invention relates to novel nucleosides of the general formula I (see formula sheet), their preparation and their use. They have a therapeutic, in particular virostatic and cancerostatic...
DE4304038A1 Cytarabine derivatives, their preparation and use  
Cytarabine derivatives of the formula in which R<1> to R<4> have the meaning stated in the description, and their preparation are described. The compounds are suitable, directly or in the form of...
DE4302459A1 Sulfocumarinhaltige nucleotides and their use in detection procedures for nucleic acids  
The invention relates to the preparation of nucleotides with a fluorescent coumarin residue as substituents, the enzymatic incorporation of these nucleotides into nucleic acids and the detection...
DE4239531A1 Reagent for the coupling of different substances to nucleic acids, and methods for its preparation  
The invention concerns a ribooligonucleotide of the formula I or II, in which R1 is a hydroxyl or phosphate group or at least one 3', 5'-nucleotide bisphosphate; R2 is a nucleobase; R3 is the...
DE4322884A1 Biologically active polymers  
The present invention relates to novel, biologically active polymers, processes for their preparation and their use for biochemical recognition reactions and / or for further reaction with...
DE4224878A1 Amphiphilic nucleoside phosphate analogues  
Amphiphilic nucleoside phosphate analogues of formula (I) and their salts are new. R1 = OH, amino (opt. acylated or alkylated or substd. with polyoxyethylene, and in which the acyl and alkyl gps...

Matches 1 - 50 out of 78 1 2 >