Matches 1 - 50 out of 50


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DE102018116200A1 METHOD FOR PRODUCING A NUCLEOTIDE SUGAR  
In a process for producing a monosaccharide-1-nucleoside diphosphate, a monosaccharide, a monosaccharide-1-phosphate kinase, a nucleoside triphosphate sugar-1-phosphate nucleosidyl transferase, a...
DE202017002052U1 Nucleoside pearl necklaces sequencing  
An apparatus for DNA sequencing by passing a single-stranded DNA or RNA strand with anhybridized, chemically modified (nucleo-) bases, nucleosides or nucleotides by a biological or non-biological...
DE102012110740A1 Preparing carbohydrate-analogs from five- or six-membered ring glycals, comprises reacting glycal by addition of ketene to corresponding cycloketone, converting cycloketonic to ketoxime, and converting ketoxime in lactam by rearrangement  
Preparing carbohydrate-analogs from five- or six-membered ring glycals, comprises: (a) reacting the glycal by the addition of ketene to the corresponding cycloketone; (b) converting cycloketonic...
DE69314239C5 Stereoselective glycosylation method  
Process for the synthesis of a nucleoside of the formula enriched in β-anomer which, if appropriate in a suitable solvent, involves carrying out a nucleophilic SN2-Substitution of a sulfonyloxy...
DE102008050273A1 Apparatus and method for synthesizing a biopolymer and method for recovering a reagent for synthesizing a biopolymer  
A Apparatus for synthesizing a biopolymer has a reaction chamber (100), an outlet (410b) connected to the reaction chamber (100) is connected, a plurality of recovery tanks (461A, 461C, 461g,...
DE202005021489U1 A composition as for the synthesis of compounds phosphitylated  
Composition, containing a compound capable of forming enolates, and a phosphoramidite.
DE102004019098A1 Caging Groups  
The This invention relates to novel nucleoside derivatives of the general Formula I, where R1 equal H, halogen, NO2, CN, OCH3. an alkyl, alkoxy or alkoxyalkyl group having 1 to 4 carbon atoms,...
DE10105077A1 Hybrid-protecting group  
The invention relates to photo-labile hybrid protecting groups and the application thereof in the synthesis of protected synthons for the light-controlled synthesis of biopolymers, in particular...
DE19837387A1 New nucleic acid analogs useful in therapeutic or diagnostic agents or electronic components, consist of 3'-deoxypentopyranosyl nucleosides  
Nucleic acid analogs (I) consisting of 3'-deoxypentopyranosyl nucleosides are new. Nucleic acid analogs (I) consisting of 3'-deoxypentopyranosyl nucleosides of formula (Ia) or (Ib) are new: R<1>,...
DE19827777A1 New nikkomycin antibiotics with antifungal, fungicidal, miticidal and insecticidal activity produced by recombinant microorganisms  
Nikkomycins Lz, Lx, Lj and Li are new. Nikkomycins of formula (I) are new: R1 = a group of formula (i) or (ii): R2 = OH or NHCH(COOH)CH2CH2COOH. An Independent claim is also included for...
DE19838506A1 The indole derivatives and their use for the treatment of malignant and other diseases based on pathological cell proliferations  
The invention relates to tyrosine kinase inhibitors of bis-indolyl compounds of formula (I), to the medicaments containing said inhibitors and to their use in treating malignant and other diseases...
DE19815901A1 A process for preparing pentopyranosylnucleosides  
The invention relates to a method for the production of a pentopyranosyl nucleoside 3', 4'-cyclic acetal, whereby a pentopyranosyl nucleoside is made to react with an aldehyde, ketone, acetal or...
DE19812162A1 Nucleotidaktivierte di- and oligosaccharides, as well as processes for their preparation I  
The invention relates to a method for the production of nucleotide activated disaccharides and oligosaccharides with n saccharide units, whereby a nucleoside diphosphate sugar (NDP sugar) is...
DE19741738A1 Linker nucleoside(s) containing alkenyloxy or phthalimido-alkyl groups  
Linker nucleosides of formula (I)-(IV) are new: R1 = H, OH or halogen (preferably Br or Cl); R2-R4 = 2-12C alkenyloxy or phthalimido(1-12C)alkyl, where phthalimido is optionally substituted by 1-4...
DE19741715A1 New pentopyranosyl nucleoside compounds  
Pentopyranosyl nucleosides of formula (I) and (II) are new. : R1 = H, OH or halogen; R2-R4 = H, NR5R6, OR7, SR8, oxo, 1-12C alkyl or (CnH2n)R10R11; n = 1-12; R10, R11 = H or 1-12C alkyl, or...
DE19703031A1 Process for the preparation of NDP-sugar  
The invention relates to a method for the production of nucleoside-diphosphate sugar (NDP-sugar), in which one sugar-1-phosphate reacts with a nucleoside-triphosophate in the presence of a...
DE19640974A1 Building blocks for DNA / PNA-co-oligomers  
The invention relates to compounds of the general formula (I) ## STR5 ## in which the substituents have the meanings given in the description. ## STR5 ## The compounds are suitable for the...
DE19640054A1 Di:nucleotide(s) with modified base, sugar and phosphate groups  
Dinucleotides with modified base, sugar and phosphate groups of formula (I) are new. R1, R6 = NH2, N3, OMe, allyl, OH, H or F; R2, R5 = O or NH; provided that when R5 is NH then R2 is not NH; and...
DE19637042A1 Heterocyclic compounds and their use in the detection of nucleic acids  
The present invention pertains to compounds of general formula (I), where R1 to R7 have the notations given in the application, as well as preparation thereof. Compounds can be used as substrates...
DE19627898A1 Solid phase synthesis of oligonucleotides  
The invention therefore provides a process for the preparation of oligonucleotides by means of solid-phase synthesis by $ A a) sequential construction of the nucleotides on a solid support...
DE19620170A1 Nucleoside derivatives having photolabile protecting groups  
The invention relates to nucleoside derivatives with photo-unstable protective groups of the general formula (I) in which R<1> is H, NO2, CN, OCH3, halogen, alkyl or alkoxyalkyl with 1 to 4 C...
DE19632823C1 Complexes of (+)-S-adenosyl-methionine and 3'-azido-2',3'-di:deoxy nucleoside compounds  
Non-covalent molecular complexes of (+)-S-adenosylmethionine (SAM) and 3'-azido-2',3'-dideoxy nucleosides are new.
DE19537334A1 New piperidine carboxylic acid and pyrrolidine carboxylic acid derivs.  
Piperidine and pyrrolidine derivs. of formula (I) are new. Z = pyranoside, pyranosyl residue bound via. the 6-position, alkyl pyranoside bound via the 6-position, furanoside, furanosyl residue...
DE19512484A1 Carbohydrate-modified cytostatics  
The invention relates to cytostatics which are made tumour-specific by modification with sugar. Suitable spacers ensure serum-stability and intracellular effect at the same time.
DE19509038A1 C-nucleoside derivatives and their use in the detection of nucleic acids  
The invention concerns pyrrolo-[3, 2-d]pyrimidine, pyrazolo-[4, 3-d]pyrimidine and pyrimidine-furanosides, i.e. so-called C-nucleosides of general formulae (I) - (V), and corresponding derivatives...
DE4444996A1 Nucleoside derivatives having photolabile protecting groups  
The invention concerns nucleoside derivatives with photolabile protective groups of general formula (I), in which R<1> is H, NO2, CN, OCH3, halogen or alkyl or alkoxyalkyl with 1 to 4 carbon...
DE4438918A1 Modified oligonucleotides, their preparation and their use  
The invention relates to novel modified oligonucleotides having at least one substituted 7-deazapurine base and forming more stable hybridization complexes with nucleic acids, the use thereof as...
DE4418691A1 3 '- (4'-) non-radioactively labeled nucleosides and nucleotides with aminocarboxylic acid, peptide or carboxylic acid-spacer  
Disclosed are 3'-(4'-) modified nucleosides and nucleotides of general formula (1), wherein R' is hydrogen, mono-, di- or triphosphate, alkyl phosphonate, dialkyl phosphinate or phosphoramidite; X...
DE4418690A1 Nucleoside 5'-mono-phosphate ester(s) of glyceryl di:ether derivs.  
Nucleoside 5'-monophosphate esters of glyceryl diether derivs. of formula (I), their salts, tautomers, optically active forms, and racemic mixts., are new: R1 = 1-20C satd. or unsatd. alkyl chain,...
DE4418842A1 Colourless, thermostable, non-toxic cyclised oligo- or poly:saccharide use as charge controller or enhancer  
The use of cyclised oligo- or polysaccharides (I) with 3-100 monomeric saccharide units as charge controllers and charge enhancers for electrophotographic toners and developers, in...
DE4335729A1 Using provided with enzymatically cleavable protecting groups nucleosides and nucleoside derivatives in the synthesis of oligonucleotides  
Process for the preparation of oligonucleotides of the formula II, in which the exocyclic amino groups of the bases adenine, guanine, cytosine, 7-deaza-adenine and 7-deaza-guanine carry...
DE4326466A1 Infrared dye-labeled nucleotides and their use in nucleic acid detection  
Nucleoside 5'-triphosphates and phosphoramidites, which at the base part or on the phosphorus atom, a long-wave absorbing radical, preferably carry a carbocyanine group of general formula (I) $...
DE4344742A1 A process for the immobilization of nucleic acids  
A method for the immobilization of nucleic acids by hybridization of the nucleic acid with a capture probe, wherein the capture probe is protected against enzymatic extension and / or enzymatic...
DE4213703A1 Fluorescence-labeled compounds, their preparation and use  
The invention relates to novel fluorescently labeled nucleosides, nucleotides and oligonucleotides of the general formula I, a process for their preparation and their use for the detection of DNA,...
DE4207363A1 Antiviral nucleoside analogs, PRODUCTION AND PHARMACEUTICAL USE  
New and known nucleoside analogues particularly effective against hepatitis B and HIV infections are disclosed, as well as their production and use.
DE4140463A1 2'-deoxy-isoguanosine WHOSE isosteres ANALOG AND USE THEREOF  
2'-desoxy-isoguanosine, isoster analogues and isoguanosine derivates having the formulas (I) to (V) are disclosed, as well as a process for preparing the same from compounds having the general...
DE4037363A1 New 2-O-alkyl nucleotide(s) and polymers contg. them - for nuclease-resistant anti-sense probes and to treat viral infection including herpes influenza and AIDS and cancer  
Nucleotide analogues of formula (I) are new. In (I) B = nucleobase; A = O or CH2; C = OR. R = alkyl, alkenyl or alkynyl comprising at least 2C atoms (especially allyl). D and E = reactive groups...
DE4005969A1 NEW trisubstituted pyrroles, METHOD FOR THE PRODUCTION AND MEDICAMENTS CONTAINING THESE COMPOUNDS  
Compounds of the formula (I) in which the substituents R<1> - R<6> have the significance set out in the claims, process for their production and medicaments containing these compounds for the...
DE3928900A1 New psoralen-modified nucleotide derivatives - used as anti-sense nucleotide(s) in the treatment of viral infections, e.g. AIDS  
Cpds. of formula (I) are mew. where B = a gp. of formula (1), (2), or (3), X4, X5 = independently H or a protecting gp, or X4 and X5 together form = CR1-NR2. n, m = 0 or 1. H1 = NH, NR2, O or S,...
DE3924424A1 NUCLEOSIDE DERIVATIVES, PROCESS FOR THEIR PRODUCTION, THEIR USE AS DRUGS AND THEIR USE IN THE nucleic SEQUENCING  
Derivatives of nucleosides and nucleotides, process for their manufacture, and use of said nucleoside derivatives as medicaments and their use in the sequencing of nucleic acids. The invention...
DE3916871A1 MODIFIED phosphoramidite METHOD FOR PRODUCING modified nucleic acids  
The invention relates to a modified phosphoramidite method for the synthesis of nucleotide sequences. By using a modified nucleoside phosphoramidite, it is possible to prepare nucleotide sequences...
DE3843117A1 NEW XANTHI DERIVATIVES WITH ADENOSINE ANTAGONISTIC EFFECT  
The invention relates to novel xanthine derivatives of general formula I, to processes for their preparation and to their use as medicaments.
DE3537877C2 D-luciferin derivatives and their use  
The invention relates to D-luciferin derivatives of the general formula (I) ## STR1 ## in which R1 = OH; alkoxy; alkenyloxy; Amino acid; NH2 or oligopeptide and R2 = H; H2PO3-; HSO3-; Alkyl or...
DE3514637C2 Novel pyran derivatives, processes for their preparation and therapeutic compositions containing these compounds  
The invention relates to novel pyran derivatives of the formula $ F1 in which X1 is H, Cl or Br and Z stands for $ F2, where X2 is H, Cl or Br is, T is O or S and Y is an arabinose, Xylose or...
DE3514641C2 New Bornanderivate, process for their preparation and therapeutic compositions containing these compounds  
The invention relates to bornane derivatives of formula $ F1 wherein X = H, Cl or Br T = O or S and Y is an arabinose, xylose or ribose residue in acetylated or non-acetylated form having either...
DE3508356C2 β-linked sialic acid derivatives, processes for their preparation and their use  
The invention relates to novel N-acetylneuraminic acid derivatives of the general formula I $ F1 in which the radicals R1 independently of one another are hydrogen atoms or acetyl groups, R2 is a...
DE2122529C2 Thiophosphate analogues of the nucleoside di- and triphosphates and process for their preparation  
The invention relates to a thiophosphate analogues of nucleoside di-thyrosphates in which an oxygen atom on the terminal phosphorus atom of the phosphoric anhydride chain is replaced by a sulfur...
DE3606395A1 Nucleic acid building blocks, process for their preparation and their use  
2'-Deoxyribonucleosides whose 5'-OH group is protected by a base-labile group, and use of these 2'-deoxyribonucleosides for preparing oligodeoxyribonucleotides.
DE3606394A1 Ribonucleosides, process for their preparation and their use  
Ribonucleosides whose 2'-OH group is blocked by a beta -activated alkylsulphonyl group, process for their preparation and use of these ribonucleosides for preparing oligoribonucleotides.
DE3531102A1 Epiminopyranosides, process for their preparation, and their use  
3,4-Dideoxy-3,4-epiminopyranosides are described, in which the free hydroxy group is in the 2-position in the trans-position to the epimino group, and 2,3-dideoxy-2,3-epiminopyranosides in which...

Matches 1 - 50 out of 50