Matches 1 - 50 out of 116 1 2 3 >


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DE112017002818T5 Compound for use in an enzymatic reaction and mass spectrometry methods  
A compound used in the conventional enzymatic reactions and mass spectrometry methods must be changed in structure as a substrate compound, such as the length of an alkyl chain contained therein,...
DE102015008631A1 Medicines for cancer therapy  
The present invention relates to novel chemical compounds, in particular benzophenone derivatives, which are suitable as active ingredients in the medicinal treatment of cancer.
DE69434744T3 POSITIVE SELEKTION AUF MANNOSE ODER XYLOSE BASIEREND  
PCT No. PCT/EP94/00575 Sec. 371 Date Oct. 3, 1995 Sec. 102(e) Date Oct. 3, 1995 PCT Filed Feb. 28, 1994 PCT Pub. No. WO94/20627 PCT Pub. Date Sep. 15, 1994The present invention provides a method...
DE10085149B4 A process for preparing acarbose with high purity  
Disclosed herein is a process for preparing highly pure acarbose of formula (I) useful as medicine for the treatment of diabetes. The disclosed process comprises prepurifying an...
DE69838449T2 Aminooxy-modified oligonucleotides  
Nucleotide compositions containing aminooxy moieties are provided. In accordance with preferred embodiments, oligonucleotides and oligonucleotide analogs are provided which are specifically...
DE69434940T2 1,2-dioxetanes with improved chemiluminescence  
Novel 1,2-dioxetanes with improved chemiluminescent properties, such as signal intensity, S/N ratio, T½, -etc. are provided by spiroadamantyl 1,2-dioxetanes, wherein the remaining carbon atom of...
DE60311649T2 C-aryl glucosides SGLT2 inhibitors and method  
An SGLT2 inhibiting compound is provided having the formula A method is also provided for treating diabetes and related diseases employing an SGLT2 inhibiting amount of the above compound alone or...
DE60218165T2 Lipolysis for reducing body weight and medical application  
New lipolysis accelerator comprises a dihydroxyphenyl derivative (I). New lipolysis accelerator comprises a dihydroxyphenyl derivative of formula (I); [Image] Z : CHOHCH 3or COCH 3; R 1, R 2H or...
DE69837295T2 Succinic acid ester of probucol for inhibiting the expression of VCAM-1  
This invention is in the area of methods and compositions for the inhibition of the expression of VCAM-1 and, in particular, for the treatment of diseases mediated by VCAM-1, including...
DE60121557T2 METABOLITES OF ESTROGEN agonists / antagonists  
This invention relates to compounds that are mammalian metabolites of (-)-cis-6-phenyl-5-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-5,6 ,7,8-tetrahydro-naphthalene-2-ol. The compounds of the invention...
DE60122193T2 Glucopyranosyloxybenzylbenzene DERIVATIVES AND MEDICAL COMPOSITIONS CONTAINING THESE COMPOUNDS  
The present invention relates to glucopyranosyloxybenzylbenzene derivatives represented by the general formula: wherein P represents a group forming a prodrug; and R represents a lower alkyl...
DE60119562T2 IMPROVED SYNTHESIS OF BLOCKED PURIN-Nucleic Acid Analogs  
The present invention relates to a new method for the synthesis of purine LNA (Locked Nucleic Acid) analogues which provides a higher overall yield. The method comprising a regioselective 9-N...
DE69434744T2 POSITIVE SELECTION TO MANNOSE OR BASED xylose  
PCT No. PCT/EP94/00575 Sec. 371 Date Oct. 3, 1995 Sec. 102(e) Date Oct. 3, 1995 PCT Filed Feb. 28, 1994 PCT Pub. No. WO94/20627 PCT Pub. Date Sep. 15, 1994The present invention provides a method...
DE60124030T2 Treatment of rumen acidosis with Amylasehemmern  
Inhibitors of rumen bacterial alpha-amylase and/or alpha-glucosidase are useful in the preparation of medicaments for the curative, palliative and prophylactic treatment of rumen acidosis and...
DE69434814T2 1,2-dioxetanes with improved chemiluminescence  
Novel 1,2-dioxetanes with improved chemiluminescent properties, such as signal intensity, S/N ratio, T½, -etc. are provided by spiroadamantyl 1,2-dioxetanes, wherein the remaining carbon atom of...
DE60118774T2 SUBSTITUTED PHENOL DERIVATIVES AND THEIR SALTS AS INHIBITORS OF coagulation FACTOR X  
There are provided compounds having an anticoagulant action on the basis of inhibition of activated blood coagulation factor X and being useful as anticoagulants or preventive/therapeutic agents...
DE60208809T2 Enzyme substrates for the detection of ß-D-ribofuranosidase activity  
A method of detecting β-D-ribofuranosidase activity in bacterial samples includes the step of incubating a sample to allow bacterial growth in the presence of chromogenic β-D-ribofuranosidase...
DE60209343T2 AMINO COMPLEX OF C-ARYLGLYCOSIDEN FOR THE TREATMENT OF DIABETES AND METHOD  
Crystalline complexes are obtained from a 1:1 or 2:1 mixtures of either the (D) or (L) enantiomer of natural amino acids and compounds of formulawhereinR<1>, R<2 >and R<2a >are independently...
DE60117012T2 O-glucoside SGLT2 INHIBITORS AND METHOD ARYL  
whereinwhen Y isor heteroaryl;A is -O(CH2)m, S, -NH(CH2)m, or (CH2)n where n is 0-3 and m is 0-2;and R<1 >to R<6 >are as defined herein.A method is also provided for treating diabetes and related...
DE60208063T2 Chromogenic ENZYME SUBSTRATES AND METHOD FOR DETECTION OF BETA-D-ribofuranosidase EFFECTIVENESS  
A method of detecting β-D-ribofuranosidase activity in bacterial samples includes the step of incubating a sample to allow bacterial growth in the presence of chromogenic β-D-ribofuranosidase...
DE60208351T2 GLUKOPYRANOSYLOXYBENZYLBENZOLDERIVATE AND THEIR MEDICAL USE  
The present invention provides glucopyranosyloxybenzylbenzene derivatives represented by the general formula: wherein P represents a hydrogen atom or a group forming a prodrug; R<1> represents a...
DE60115623T2 Glucopyranosyloxy-BENZYLBENZEN DERIVATIVES, MEDICINAL COMPOSITION AND INTERMEDIATE PRODUCTS FOR THE PRODUCTION OF DERIVATIVES  
The present invention relates to glucopyranosyloxybenzylbenzene derivatives represented by the general formula: wherein R<1> represents a hydrogen atom or a hydroxy( lower alkyl) group; and R<2>...
DE69832825T2 Chromogenic SIALIDASESUBSTRATE AND METHOD FOR THEIR PRODUCTION AND USE  
The subject invention discloses materials and methods for the design, synthesis, and biochemical evaluation of chromogenic substrate compounds for sialidases of bacterial, viral, protozoa, and...
DE69831566T2 PROBUCOL MONOESTER ZUR BEHANDLUNG VON KREISLAUF- UND ENTZÜNDUNGSERKRANKUNGEN  
This invention is in the area of methods and compositions for the inhibition of the expression of VCAM-1 and, in particular, for the treatment of diseases mediated by VCAM-1, including...
DE60113418T2 ANTI-CARCINOGENIC ACTIVITY OF FROM LIQUORICE ROOT ISOLATED hydroxylated chalcone COMPOUNDS  
Compositions and methods are provided for prevention and treatment of cancer. The compositions comprise pure hydroxylated chalcone compounds of licorice root (Glycyrrhiza glabra) including...
DE60112769T2 Tetraphenylbacteriochlorinderivate and these compositions enthaltdenden  
Provided is a tetraphenylbacteriochlorin derivative represented by the formula (I): Äwherein R<1>, R<2>, R<3> and R<4>, independently from each other, are a residue of a monosaccharide represented...
DE69133471T2 Azole derivatives and their use as inhibitors of superoxide radicals  
A superoxide radical inhibitor containing, as an effective ingredient, an azole derivative represented by the general formula (1), Äwherein R<1> represents a phenyl group which may have 1-3 lower...
DE60111467T2 A hollow fibrous organic nanotube and process for its preparation  
A novel hollow fibrous organic nanbtube can be produced by a simple procedure from a readily available and inexpensive natural material, which is regenerable and has a wide range of application....
DE69829966T2 A monoether of probucol AND METHODS FOR INHIBITING VCAM-1 EXPRESSION  
This invention is in the area of methods and compositions for the inhibition of the expression of VCAM-1 and, in particular, for the treatment of diseases mediated by VCAM-1, including...
DE10258007B4 Aromatic Fluorglycosidderivate, medicaments containing these compounds and methods for making these medicines  
Novel aromatic fluoroglycoside derivatives, medicaments containing these compounds, and the use thereof. The invention relates to substituted aromatic fluoroglycoside derivatives of the formula I...
DE10258008B4 Heterocyclic Fluorglycosidderivate, medicaments containing these compounds and methods for making these medicines  
Novel heterocyclic fluoroglycoside derivatives, medicaments containing these compounds, and the use thereof The invention relates to substituted heterocyclic fluoroglycoside derivatives of the...
DE60020259T2 C-ARYL-glucoside SGLT2 INHIBITORS  
SGLT2 inhibiting compounds are provided having the formulawhereR1, R2, and R2a are independently hydrogen, OH, OR5, lower alkyl, CF3, OCHF2, OCF3, SR5i or halogen, or two of R1, R2 and R2a...
DE60013161T2 NEW fucosylated oligosaccharides and AND METHOD FOR PRODUCING  
The present invention relates to a process for the preparation of oligosaccharides or oligosaccharide containing compounds, especially N-acetyl-chitooligosaccharides having a fucosylated...
DE69034194T2 N-acyl derivatives of the antitumor antibiotics of the type LL-E33288  
The invention is N-acyl and dihydro-N-acyl analogs of the family of antibacterial and antitumor agents known collectively as the E33288 complex.
DE69533615T2 Anthracycline prodrugs, processes for their preparation and their use in selective chemotherapy  
Anthracycline derivatives are disclosed which are coupled to an enzymatically cleavable N-phenyl-O-glycosyl carbamate spacer group, which derivatives are represented by the formula as well as the...
DE69333611T2 RADIO MARKED polyhydric phenol COMPOUNDS  
PCT No. PCT/US93/12272 Sec. 371 Date Jun. 20, 1995 Sec. 102(e) Date Jun. 20, 1995 PCT Filed Dec. 16, 1993 PCT Pub. No. WO94/14477 PCT Pub. Date Jul. 7, 1994The invention relates to polyhydric...
DE69729958T2 LINKS WITH ANTIVIRAL ACTIVITY  
In order to provide the anti-retrovirus active compound with low anti-coagulant action and low cytotoxicity, compounds comprising glycoside or the salt thereof wherein lipid is linked to position...
DE69433901T2 COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT AND PREVENTION OF BACTERIAL INFECTIONS  
Novel methods for the treatment and/or prophylaxis of diseases caused by tissue-adhering bacteria are disclosed. By interacting with periplasmic molecular chaperones it is achieved that the...
DE10361133A1 Glucopyranosyloxy-substituted aromatics, pharmaceutical compositions containing them, their use and processes for their preparation  
The present invention relates to glucopyranosyloxy-substituted aromatics of the general formula, in theR1 to R6 and R7a, R7b, R7c the claim 1 are defined, the tautomers, the stereoisomers, the...
DE69915848T2 USE OF NEOHESPERIDINE DIHYDROCHALCONE FOR PRODUCING A MEDICAMENT FOR PREVENTION OR TREATING DISEASES DUE high blood fats  
A pharmaceutical composition for treating or preventing an elevated blood lipid or glucose level-related disease such as hyperlipidemia, arteriosclerosis, angina pectoris, stroke, hepatic diseases...
DE60008111T2 USE OF BETA-NAPHTAQUINON DERIVATIVES FOR PRODUCING A PRODUCT WITH A inhibitory effect on glutamate release THROUGH THE BRAIN  
The present invention relates to the use of beta-naphthoquinone derivatives, and salts thereof, for the prevention and/or the treatment of glutamate cytotoxicity. It further relates to the use of...
DE69913333T2 HYGROMYCIN A DERIVATE  
This invention relates to compounds of the formulaand to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R1 and R2 are as defined herein. The compounds of formula 1 are...
DE10258007A1 New aromatic Fluorglycosidderivate, pharmaceutical compositions containing them and their use  
The invention relates to substituted aromatic Fluorglycosidderivate of the formula I, wherein the radicals have the meanings indicated, and their physiologically acceptable salts and processes for...
DE10300049A1 New compounds which inhibit factor VIIa  
The present invention relates to novel compounds of formula (I): These compounds are very potent factor VIIa inhibitors and are therefore especially in the treatment and / or prevention of...
DE10258008A1 New heterocyclic Fluorglycosidderivate, pharmaceutical compositions containing them and their use  
The invention relates to substituted heterocyclic Fluorglycosidderivate of the formula I, wherein the radicals have the meanings indicated, and their physiologically acceptable salts and processes...
DE69629721T2 CARNAMOYLOXY DERIVATIVES of mutilin AND THEIR USE AS ANTIBACTERIAL AGENT  
PCT No. PCT/EP96/05874 Sec. 371 Date Dec. 4, 1998 Sec. 102(e) Date Dec. 4, 1998 PCT Filed Dec. 19, 1996 PCT Pub. No. WO97/25309 PCT Pub. Date Jul. 17, 1997Derivatives of mutiline of formula (1A)...
DE69908936T2 2 '' - DEOXYHYGROMYCINDERIVATE  
This invention relates to compounds of the formulaand to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R1 and R2 are as defined herein. The compounds of formula 1 are...
DE69912058T2 Proactive anti tumors compounds  
The present invention features proactive antitumor compounds of the following formula: wherein R<1> is COOZ; Z being H, alkali metal, alkaline earth metal, an ammonium group which is optionally...
DE60003718T2 BENZOPHENONE ALPHA GLYCOPYRANOSIDE, PREPARATION AND THERAPEUTIC USE  
The invention concerns (i) [4-(4-cyanobenzyl)phenyl] alpha -D-glycopyranosides of formula (I) wherein: the group alpha -D-glycopyranosyl R represents a alpha -D-glycopyranosyl, alpha...
DE10111682B4 Caloporoside derivatives, processes for their preparation and their use  
The present invention relates to novel caloporoside derivatives and method of their use. The caloporoside derivatives may be formed by fermentation of microorganisms, such as Gloeoporus dichrous...

Matches 1 - 50 out of 116 1 2 3 >