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DE60224291T2 SYSTEM FOR ANTIBODY EXPRESSION AND SYNTHESIS  
The present invention provides methods and compositions for expression and production of recombinant antibodies in a host cell system, such as prokaryotic and eukaryotic expression systems....
DE60131970T2 GENETIC DIAGNOSIS TO THE IDENTIFICATION OF QT EXTENSIONS AS ADVERSE REACTION TO MEDICINES  
The specification is directed to a method of diagnosing whether a subject is predisposed to an adverse reaction to one or more pharmaceutical agents which may induce a prolonged QT interval or...
DE69738409T2 A method for producing surfaces with lower binding affinity  
Hydrophobic polymer surfaces whose level of protein binding is less than about 50-80 ng/cm2 are achieved by: (1) applying a coating solution composed of a solvent and a non-ionic surfactant having...
DE69738368T2 MURINE alpha (1,3) fucosyltransferase (Fuc-TVII)  
A gene which encodes a murine leukocyte α(1,3)fucosyltransferase capable of synthesizing the sialyl Lewis x determinant has been cloned.
DE69535669T2 RETRO VIRAL VECTORS WITH REDUCED recombination  
Retroviral vector constructs are described which have a 5' LTR, a tRNA binding site, a packaging signal, one or more heterologous sequences, an origin of second strand synthesis and a 3' LTR,...
DE69201441T3 AGENTS OF MYSTERIOUS SWINE DISEASE, VACCINE COMPOSITIONS AND DIAGNOSTIC KITS.  
Composition of matter comprising the causative agent of Mystery Swine Disease, Lelystad Agent, in a live, attenuated, dead, or recombinant form, or a part or component of it. Vaccine compositions...
DE60224163T2 COMBINATION of ezetimibe AND ASPIRIN FOR THE TREATMENT OF CARDIOVASCULAR DISEASES  
The present invention provides compositions, therapeutic combinations and methods including: (a) at least one sterol absorption inhibitor, and (b) at least one blood modifier, which can be useful...
DE602005003922T2 Synthesis of spongosine  
Reaction of 1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose with 2-methoxyadenine to form 9-(2′,3′,5′-tri-O-benzoyl-β-D-ribofuranosyl)-2-methoxyadenin e, then deprotection of the...
DE60131973T2 REGULATION OF UPA GEN EXPRESSION BY methylated NUCLEOTIDES  
The present invention provides a method of regulating the expression of the urokinase type plasminogen activator ("uPA") gene in a mammalian cell comprising the steps of: identifying a target...
DE60131903T2 DIRECT MULTIPLEX CHARACTERIZATION OF GENOMIC DNA  
The invention is directed to novel methods of multiplexing nucleic acid reactions, including amplification, detection and genotyping. The invention relies on the use of precircle probes that are...
DE60037313T2 PHARMACEUTICAL COMPOUNDS  
Compounds or their salts having general formula: A-B-C-NO2 wherein: A is a drug radical; B is a linker; and C is a bivalent radical.
DE60223812T2 METHOD FOR VIRUS PROPAGATION  
The present invention relates to a process for producing poxvirus, in particular Chordopoxvirus, wherein the poxvirus is cultivated at a temperature below 37° C. The process leads to increased...
DE19730408B4 Composition for topical application  
A composition for external application having excellent percutaneous absorption property and skin-lightening and whitening effects, is disclosed, which composition comprises at least one...
DE60223704T2 DEVICE FOR EXTRACTION OF NUCLEIC  
The test tubes containing test sample and glass beads of different grain sizes, are mounted in the centrifuge. The material that includes nucleic acid, is separated from glass beads by shaking the...
DE60037012T2 INHIBITORS OF ENDOTHELIN-1 SYNTHESIS  
Sequences in human preproendothelin-1 mRNA are described against which antisense oligonucleotides can be used to inhibit the synthesis of endothelin-1. This inhibition of endothelin-1 synthesis...
DE102007053947A1 A process for the synthesis of sucrose-6-acetic acid ester  
The This invention discloses a method for the synthesis of sucrose-6-acetic acid esters, comprising the steps of: adding sucrose in a polar, aprotic solvent and stirring the solvent, to solve...
DE60131430T2 Oligodeoxynucleotides AND THEIR USE FOR inducing an immune response  
Compositions including multiple oligodeoxynucleotides with a CpG motif are disclosed herein. The compositions can include either D or K type oligodeoxynucleotides. These compositions are of use in...
DE102006035392A1 Prognostic markers for predicting the five-year progression-free survival of patients with colon cancer based on expression profiles of biological samples  
The Invention relates to the use of gene expression profiles for Prediction of the five-year progression-or relapse-free survival of patients undergoing colorectal a was removed carcinoma in UICC...
DE69637332T2 Combining of PDGF, KGF, IGF and IGFBP for wound healing  
The invention provides a therapeutical composition for epithelial wound repair that is a combination of PDGF and KGF. Further, the invention provides a composition for epithelial wound repair that...
DE102007016367A1 Polymorph of Clarithromycin (Form V)  
The Invention relates to a polymorphic form of clarithromycin (form V), their preparation and use.
DE102007015775A1 A method for detecting Paratuberkolose  
The This invention relates to a method for specifically and sensitive detection of Mycobacterium avium ssp. paratuberculosis (MAP). In fecal, tissue and organ samples using a real-time PCR methods
DE69435048T2 SYSTEMATIC EVOLUTION OF LIGANDS BY EXPONENTIAL ENRICHMENT: PHOTO SELECTION OF NUCLEIC LIGANDS  
A method for identifying nucleic acid ligands to target molecules using the SELEX procedure wherein the candidate nucleic acids contain photoreactive groups and nucleic acid ligands identified...
DE60037195T2 COMPOUNDS FOR THE TREATMENT OF INFECTIOUS DISEASES AND DISORDERS OF THE IMMUNE SYSTEM AND METHODS OF THEIR USE  
The present invention provides polypeptides comprising an immunogenic epitope of a M. vaccae protein, polynucleotides encoding such polypeptides, and fusion proteins comprising at least one such...
DE69838903T2 Sulfonamide derivatives as prodrugs of inhibitors of aspartyl protease  
The present invention relates to prodrugs of a class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of prodrugs of HIV aspartyl...
DE602004010110T2 NEW 14- AND 15-PRONGED RING COMPOUNDS  
The present invention relates to 15-membered macrolides substituted at the 4'' position of formula (I) and pharmaceutically acceptable derivatives thereof, to processes for their preparation and...
DE102006050091A1 Process for the selective localization of active ingredients to and in mitochondria and corresponding active ingredients  
The This invention relates to novel processes for the selective localization of active ingredients both at and in mitochondria within living cells and agents that through without further aids...
DE69435043T2 CHECKING THE expression of IGF-I GENE  
Double-stranded DNA (I) encoding an RNA (II) able to form a triple helix with a single-stranded nucleic acid target (III) is new. Also claimed are: (1) expression vectors contg. (I) and (2) (II),...
DE102007010252A1 Set of control genes for normalizing gene expression data from blood samples comprises seven RNA sequences  
Set of control genes for normalizing gene expression data from blood samples comprises seven RNA sequences corresponding to GenBank accession numbers NM001562, NM001228, NM001993, NM002209,...
DE69535634T2 MODULATORS OF THE FUNCTION OF FAS / AP01 RECEPTOR  
Proteins capable of modulating the function of FAS/APO1 are provided. The proteins may be prepared by culturing a host cell transformed with a vector containing the DNA encoding such a protein...
DE60222812T2 IN LEPTOSPIRA SPECIES EXISTING PROTEINS with repetitive BACTERIA-IG-LIKE (BIG) DOMAINS  
The invention relates to three isolated DNA molecules that encode for proteins, BigL1, BigL2 and BigL3, in the Leptospira sp bacterium which have repetitive Bacterial-Ig-like (Big) domains and...
DE60131250T2 Nucleoside analogues WITH MONO CYCLIC ALKALINE CARBOXAMIDINGRUPPEN  
The inventions relates to the use of the carboxamidine of Formula 1, or a pharmaceutically acceptable salt thereof, for the manufacture of a medicament for the treatment of a Hepatitis C Virus...
DE102007010311A1 Organism-specific hybridizable nucleic acid molecule  
The This invention relates to a method for producing a organism-specific hybridizable nucleic acid molecule, a product made by this method nucleic acid molecule, a kit which comprises at least one...
DE102007009073A1 Crosslinked poly(meth)acrylic acid cation exchanger, e.g. for water treatment, is obtained by polymerizing pearl-form monomer drops while supplying monomers, crosslinker and optionally initiator  
Production of crosslinked poly(meth)acrylic acid type cation exchangers (I) involves polymerizing pearl-form monomer drops in a (preferably aqueous) continuous phase, while supplying a mixture of...
DE69937450T2 METHODS FOR THE DESIGN OF PROTEIN LINKED lipidic MICROPARTICLES AND CONNECTIONS IN ORDER  
The present invention relates to lipidic microparticles with attached proteins which have been first conjugated to linker molecules having a hydrophilic polymer domain and a hydrophobic domain...
DE69937439T2 Improved deprotection procedure for the synthesis of oligomer compounds  
Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, phosphorodithioate, or other covalent linkages. The oligomers have substantially...
DE69535133T2 HUMANIZED ANTIBODY AGAINST THE leukocyte VLA-4  
The invention provides humanized immunoglobulins that specifically bind to the VLA-4 ligand, and methods of treatment using the same. The methods are particularly useful for the treatment of...
DE102007007644A1 New aminocoumarin compounds, designated novclobiocins, useful as broad-spectrum antibiotics and cytotoxic agents, prepared sing genetically modified bacterial strains  
New aminocoumarin compounds (I), designated novclobiocins, consist of clorobiocin analogs containing modified N-acyl residues and/or 8-substituents. Aminocoumarin compounds of formula (I) are new....
DE69637391T2 MODIFIED MYELIN PROTEIN MOLECULES  
Compositions and methods are provided for the clinical assessment, diagnosis, and treatment of multiple sclerosis. The compositions of the invention are molecules related to the human proteolipid...
DE60223232T2 MUCINPEPTID WITH immune boosting PROPERTIES  
An isolated peptide or polypeptide containing the sequence VSIGLSFPMLP (SEQ ID NO:1), found in the secreted form of human MUC1, that enhances an immune response when administered to a mammal,...
DE102007007738A1 Color-coded oligosaccharides or polysaccharides  
The Invention relates to color-marked oligosaccharides or polysaccharides, process for producing these color-marked oligosaccharides or polysaccharides and their use for kidney function determination.
DE102005047736B4 Method and system for isolating nucleic acids from any complex starting materials  
systems without chaotropic and antichaotropic components for isolating nucleic acids from nucleic acids containing materials comprising • at least a per se known Buffer for proteolytic digestion...
DE69435038T2 Activin Receptor-LIKE KINASE (ALK), belonging to TGF RECEPTOR FAMILY AND / OR FOR BMP RECEPTOR FAMILY  
Novel serine/threonine receptor proteins and BMP receptor proteins are disclosed, as well as DNA molecules encoding said proteins and methods of using the receptor proteins. Further disclosed are...
DE60131194T2 SEQUENCE DETERMINATION IN REAL TIME  
A method for determining if or when a monomer is incorporated into a growing DNA chain associated with a polymerase, where a tag is located on the polymerase so that as the pyrophosphate group is...
DE102007005804A1 Secreted luciferase Lu164M3 and their use  
The Invention relates to the nucleotide and amino acid sequence and the type and use of Lu164M3 and the Use of secreted luciferases.
DE102007005803A1 Secreted luciferase MLuc7 and their use  
The Invention relates to the nucleotide and amino acid sequence and the type and use of the secreted luciferase MLuc7.
DE102007005655A1 Apparatus and method for purification of nucleic acids  
disclosed A device for purification of nucleic acids by negative chromatography comprising a hollow body each having an opening at the upper and at the lower end, which includes a stationary solid...
DE60316953T2 METHOD FOR CONTROL OF HAIR BALES  
Disclosed are methods for increasing fecal hair excretion and for treating hairballs in a mammal by administering a composition comprising polyol fatty acid polyester. Further disclosed are...
DE102005011003B4 Method and means for the differential diagnosis of thyroid tumors  
process for the differential diagnosis of thyroid tumors to differentiate of benign tumors to malicious Tumors wherein: 1) RNA is isolated from a tissue sample of the thyroid gland, 2.) in the...
DE602004013276T2 METHOD FOR PRODUCING isomalto-oligosaccharides EXTENDED CHAIN ​​AND LOW glycemic index  
The invention relates to a process for preparing isomalto-oligosaccharides with elongated chain length. Isomalto-oligosaccharides are directly converted to isomalto-oligosaccharides with elongated...
DE602004009435T2 BY CD26 FISSILE HIV PRODRUGS  
The present invention provides new prodrugs which are conjugates of a therapeutic compound and a peptide wherein the conjugate is cleavable by dipeptidyl-peptidases, more preferably by CD26, also...