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DE102007038037A1 Eukaryotic promoters for gene expression  
The Invention provides promoters prepared from yeast Arxula adeninivorans which are nitrate inducible genes of nitrate reductase (AYNR1) Nitrite (AYNI1) or the nitrate transporter (AYNT1) descended.
DE60038038T2 phosphonate  
The present invention relates to phosphonate compounds, compositions containing them, processes for obtaining them, and their use for treating a variety of medical disorders, e.g., osteoporosis...
DE102004063099B4 A process for preparing Thiophenglycosidderivaten  
The present invention relates to a process for preparing thiophene-glycoside derivatives of the general formula (I)
DE69839133T2 Isolation of nucleic acids  
A method of extracting nucleic acids from blood comprises contacting blood cells, preferably after lysing with an activated solid phase at one pH to immobilise the nucleic acids and then removing...
DE69133591T2 CNP gene and precursor protein from pork  
The gene and cDNA of a procine derived CNP (C-type natriuretic peptide), and a procine derived CNP precursor protein and derivatives thereof are disclosed. The proceine derivative CNP precursor is...
DE60319103T2 SUBSTANCES FOR PREVENTION AND TREATMENT OF AUTOIMMUNE DISEASES  
A substance is disclosed for preventing, delaying the onset of or treating one or more than one autoimmune disease, the substance comprising a combination of a polynucleotide construct comprising...
DE60319083T2 PHARMACEUTICAL COMPOUND AND METHODS FOR TREATING HUMAN CARCINOMA USING ARGININE-WITHDRAWAL  
The present invention provides an isolated and substantially purified recombinant human arginase having sufficiently high enzymatic activity and stability to maintain Adequate Arginine Depletion...
DE19805822B4 11-acetyl-12,13-dioxabicyclo [8.2.1] tridecenon derivatives, processes for their preparation and pharmaceutical compositions containing them  
(2R,3S,4S,5R,6R,10R,11R)-2,4,6,8,10-Pentamethyl-11-acetyl-12 ,13- dioxabicyclo(8.2.1)tridec-8-en-1-one compounds are new. (2R,3S,4S,5R,6R,10R,11R)-2,4,6,8,10-pentamethyl-11-acetyl-12 ,13-...
DE102008028357A1 New Hybrid System for Brassica napus  
The present invention relates to a conditional kerngenisch inherited Male sterility system in Brassica napus. Embodiments of the present invention provide the (Male sterile) female line precursor...
DE102007035730A1 Determining linezolid-resistance in microorganism comprises contacting microorganism with oligonucleotide-probe that can bind to microorganism ribosomal RNA showing point mutation caused by linezolid-resistance and detecting microorganism  
Determination of linezolid-resistance in microorganisms present in a sample, comprises contacting the sample with at least an oligonucleotide-probe, which can bind under hybridization conditions...
DE69531678T3 REKOMBINATIE VIRUSES, THEIR PRODUCTION AND THEIR USE IN GENE THERAPY  
Recombinant viruses comprising a heterologous. DNA sequence coding for a lipase involved in lipoprotein metabolism. The invention also concerns the preparation and use in therapy of said...
DE69435071T2 THE TUMORS SUPPRESSIVE PROTEIN PRB2, RELATED gene, and encoding DNA  
The invention provides a tumor suppressor protein of the retinoblastoma family (pRb2) which binds to the E1A transforming domain and to DNA encoding for the pRb2 protein.
DE60037938T2 ANTISENSE THERAPY FOR TRPM-2  
A method for treating an individual suffering from a cancer comprising administering to the individual i) a chemotherapeutic agent, and ii) one antisense oligonucleotide having nucleotides in the...
DE60036534T2 SOLID PHARMACEUTICAL FORMULATIONS BASED ON SULFOALKYLETHERN the cyclodextrin FOR DELAYED RELEASE  
An osmotic solid pharmaceutical formulation for the controlled diffusional and osmotic delivery of a therapeutic agent to an environment of use comprising: a core comprising a physical mixture of...
DE102007035250A1 A method for separating non-proteinaceous biomolecules, in particular nucleic acids from protein-containing samples  
The This invention relates to a process for isolating non-proteinaceous biomolecules, in particular nucleic acids, wherein on a solid phase, a protein degradation is carried out.
DE60224816T2 Subcellular targeting of therapeutic proteins  
Targeted therapeutics that localize to a specific subcellular compartment such as the lysosome are provided. The targeted therapeutics include a therapeutic agent and a targeting moiety that binds...
DE102007032799A1 New sugar-containing polypyridine metal complexes e.g. useful as fluorescence markers in biological systems or for treating abnormal cells  
Sugar-containing polypyridine metal complexes (I) are new. Sugar-containing polypyridine metal complexes of formula (I) are new. (L1 n)(L2 m)(L3 o)(L4 p)(L5 q)M (I) L1-L5 : ligands, at least one...
DE69839060T2 VEGI, AN INHIBITOR OF ANGIOGENESIS AND TUMOR GROWTH  
The present invention relates to a vascular endothelial cell inhibitor, VEGI, capable of inhibiting angiogenesis in cellular models and tumourigenesis in animal models, and methods of use.
DE69334201T2 Dominant-negative membrane-bound Flk-1 receptor of the vascular endothelial growth factor VEGF  
The present invention relates to the use of ligands for the Flk-1 receptor for the modulation of angiogenesis and vasculogenesis. The invention is based, in part, on the demonstration that Flk-1...
DE60132471T2 Modulation of immunostimulatory ACTIVITY OF immunostimulatory oligonucleotide analogs BY POSITION ELLE CHEMICAL CHANGES  
The present invention relates to immunostimulatory oligonucleotide compounds and their use as immunostimulatory agents in immunotherapy applications.
DE60224569T2 MATERIALS AND METHODS FOR RELEASE GENETIC MATERIAL  
The invention provides methods for isolating and releasing genetic material from a solid medium, such as a DNA array, a filter, a card, or a multiple-well plate, using a wash solution comprising a...
DE60224401T2 HEPATITIS C VIRUS POLYMERASE INHIBITORS WITH HETEROBICYLISCHER STRUCTURE  
An isomer, enantiomer, diastereoisomer or tautomer of a compound, represented by formula I: wherein: A is O, S, N R 1 , or C R 1 , wherein R 1 is defined herein; ----- represents either a single...
DE10319917B4 Process for the selective carbohydrate oxidation using a supported gold catalysts  
Selective oxidation of a carbohydrate (mixture) or composition containing a carbohydrates comprises reacting an aqueous solution of the carbohydrate or composition in presence of oxygen and a gold...
DE69738466T2 Streptococcus pneumoniae methionyl tRNA SYNTHETASE  
The invention provides metS polypeptides and DNA (RNA) encoding metS polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing...
DE602004011272T2 SPECIFIC ANTAGONIST BOTH e AND AS P-selectins  
Compounds and methods are provided for modulating in vitro and in vivo processes mediated by selectin binding. More specifically, selectin modulators and their use are described, wherein the...
DE602004010741T2 Using Monosachharidphosphaten to improve intestinal function  
The present invention relates to an alternative agent with vitamin D-like activity or an improving agent for age-related depression of intestinal function, comprising a sugar-phosphate ester or a...
DE60037514T2 AQUEOUS IMMUNOLOGICAL ADJUVANTZUSAMMENSETZUNGEN OFF monophosphoryl lipid A  
An aqueous adjuvant composition comprising an attenuated lipid A derivative and a non-immunostimulatory surfactant or surfactants enhances the immunological response in a warm blooded animal to a...
DE102007028030A1 Biosurfactants and their preparation  
The Invention relates to a process for Biotensidherstellung wherein biotensiderzeugende microorganisms in a growing medium be moved. It is provided that the growing medium used in excess and a...
DE69637389T2 Covalent COUPLED Oligonucleotide (MINOR GROOVE BINDER) conjugates  
Conjugates between a minor groove binding molecule, such as the trimer of 1,2-dihydro-(3H)-pyrrolo[3,2-e]indole-7-carboxylate (CDPI3), and an oligonucleotide form unusually stable hybrids with...
DE60224400T2 HEPATITIS C VIRUS POLYMERASE INHIBITORS WITH HETEROBICYLISCHER STRUCTURE  
An isomer, enantiomer, diastereoisomer or tautomer of a compound, represented by formula I: wherein: A is O, S, N R 1 , or C R 1 , wherein R 1 is defined herein; ----- represents either a single...
DE602004010916T2 METHOD FOR LUNG hersel of 2 ', 3'-didehydro-2', 3'-dideoxynucleosides and 2 ', 3'-dideoxynucleosides  
A process for preparing 2',3'-didehydro-2',3'-dideoxynucleosides and 2',3'-dideoxynucleosides is described, which comprises the reductive elimination reaction of a compound of formula in which X,...
DE60132170T2 MODULATION BY CpG OLIGONUCLEOTIDES CAUSED BY IMMUNE STIMULATION POSITION CHANGES RELATED nucleosides  
The invention provides methods for modulating the immune response caused by CpG-containing oligonucleotides. The methods according to the invention enable both decreasing the immunostimulatory...
DE69334197T2 Helicobacter pylori cytotoxin used in vaccines and diagnostics  
Helicobacter pylori is known to cause or be a cofactor in type B gastritis, peptic ulcers, and gastric tumors. In both developed and developing countries, a high percentage of people are infected...
DE60224291T2 SYSTEM FOR ANTIBODY EXPRESSION AND SYNTHESIS  
The present invention provides methods and compositions for expression and production of recombinant antibodies in a host cell system, such as prokaryotic and eukaryotic expression systems....
DE60131970T2 GENETIC DIAGNOSIS TO THE IDENTIFICATION OF QT EXTENSIONS AS ADVERSE REACTION TO MEDICINES  
The specification is directed to a method of diagnosing whether a subject is predisposed to an adverse reaction to one or more pharmaceutical agents which may induce a prolonged QT interval or...
DE69738409T2 A method for producing surfaces with lower binding affinity  
Hydrophobic polymer surfaces whose level of protein binding is less than about 50-80 ng/cm2 are achieved by: (1) applying a coating solution composed of a solvent and a non-ionic surfactant having...
DE69738368T2 MURINE alpha (1,3) fucosyltransferase (Fuc-TVII)  
A gene which encodes a murine leukocyte α(1,3)fucosyltransferase capable of synthesizing the sialyl Lewis x determinant has been cloned.
DE69535669T2 RETRO VIRAL VECTORS WITH REDUCED recombination  
Retroviral vector constructs are described which have a 5' LTR, a tRNA binding site, a packaging signal, one or more heterologous sequences, an origin of second strand synthesis and a 3' LTR,...
DE69201441T3 AGENTS OF MYSTERIOUS SWINE DISEASE, VACCINE COMPOSITIONS AND DIAGNOSTIC KITS.  
Composition of matter comprising the causative agent of Mystery Swine Disease, Lelystad Agent, in a live, attenuated, dead, or recombinant form, or a part or component of it. Vaccine compositions...
DE60224163T2 COMBINATION of ezetimibe AND ASPIRIN FOR THE TREATMENT OF CARDIOVASCULAR DISEASES  
The present invention provides compositions, therapeutic combinations and methods including: (a) at least one sterol absorption inhibitor, and (b) at least one blood modifier, which can be useful...
DE602005003922T2 Synthesis of spongosine  
Reaction of 1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose with 2-methoxyadenine to form 9-(2′,3′,5′-tri-O-benzoyl-β-D-ribofuranosyl)-2-methoxyadenin e, then deprotection of the...
DE60131973T2 REGULATION OF UPA GEN EXPRESSION BY methylated NUCLEOTIDES  
The present invention provides a method of regulating the expression of the urokinase type plasminogen activator ("uPA") gene in a mammalian cell comprising the steps of: identifying a target...
DE60131903T2 DIRECT MULTIPLEX CHARACTERIZATION OF GENOMIC DNA  
The invention is directed to novel methods of multiplexing nucleic acid reactions, including amplification, detection and genotyping. The invention relies on the use of precircle probes that are...
DE60037313T2 PHARMACEUTICAL COMPOUNDS  
Compounds or their salts having general formula: A-B-C-NO2 wherein: A is a drug radical; B is a linker; and C is a bivalent radical.
DE60223812T2 METHOD FOR VIRUS PROPAGATION  
The present invention relates to a process for producing poxvirus, in particular Chordopoxvirus, wherein the poxvirus is cultivated at a temperature below 37° C. The process leads to increased...
DE60131769T2 Derivatized CARBS AND THEIR USE IN SOLID DELIVERY SYSTEMS  
In a composition comprising a therapeutic agent and a compound which is a trisaccharide or higher polysaccharide, that compound has the formula X[-Y-Z]n wherein X and Z are each saccharide...
DE19730408B4 Composition for topical application  
A composition for external application having excellent percutaneous absorption property and skin-lightening and whitening effects, is disclosed, which composition comprises at least one...
DE69838754T2 METHOD FOR PRODUCING sialyloligosaccharides FROM MILK  
The present invention provides methods for producing sialyloligosaccharides in situ in dairy sources and cheese processing waste streams, prior to, during, or after processing of the dairy source...
DE69838724T2 POLYMERASE improver FACTOR (PEF) -containing EXTRACTS, PEF PROTEIN COMPLEX, ISOLATED PEF PROTEIN AND METHOD FOR CLEANING AND IDENTIFICATION  
The invention provides novel extracts, proteins, and complexes that improve the polymerization activity of nucleic acid polymerases. Included within the aspects of the invention are methods for...
DE60223704T2 DEVICE FOR EXTRACTION OF NUCLEIC  
The test tubes containing test sample and glass beads of different grain sizes, are mounted in the centrifuge. The material that includes nucleic acid, is separated from glass beads by shaking the...