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DE69532958T2 CONJUGATES MADE OF METAL COMPLEX AND Oligonucleotides  
This invention relates to chemically modified oligonucleotide conjugates that contain a complexing agent or complex that is bound by a connecting component to the oligonucleotides. In this case,...
DE60038495T2 Oligonucleotide N3 '→ P5' thiophosphoramidates: THEIR SYNTHESIS AND USE  
Oligonucleotides with a novel sugar-phosphate backbone containing at least one internucleoside 3'-NHP(O)(S-)O-5' linkage, and methods of synthesizing and using the inventive oligonucleotides are...
DE60038449T2 MEDICINES SUBSTANCES WITH TWO LINKED COVALENTLY SUBSTANCES (SODIUM CHANNEL BLOCKER / P2Y2 RECEPTOR AGONIST) FOR THE TREATMENT OF MUCOUS MEMBRANES  
Compounds of the general formula P1-L-P2; wherein "P1" is a pyrazinoylguanidine sodium channel blocker, "L" is a linking group, and "P2" is either (i) a pyrazinoylguanidine sodium channel blocker...
DE102008012336A1 Separation of charged absolute electrostatic repulsion / hydrophilic interaction  
In one aspect includes a method of conducting an electrostatic repulsion / hydrophilic interaction chromatography to a protein, a peptide or an amino acid, the Providing a column with an...
DE102007041476A1 Aptamers that bind to a party to the hemostasis target molecule  
The Invention relates to an aptamer that binds to an haemostasis participating target molecule binds with the aptamer an aptamer is that binds to activated protein C, wherein the aptamer with a...
DE60225652T2 Oligonukleotidmarkierungsreagenzien on the basis of acyclic nucleosides, and their derivatized conjugates  
The invention relates to a labeling reactant of formula (I) useful for labeling an oligonucleotide wherein: R is a temporary protecting group. A is either a phosphorylating moiety or a solid...
DE102007044765A1 A process for the liquid phase synthesis of a polymer  
The Invention relates to a process for the liquid phase synthesis of a n monomers formed polymer.
DE602004012404T2 PROCESS FOR THE SELECTIVE INHIBITION OF HUMAN N-MYC GENE IN N-MYC EXPRESSING TUMORS THROUGH antisense and sense peptidonucleic (PNA)  
The present invention refers to sense and antisense peptide nucleic acids (PNAs). The present invention further refers to the use of said PNAs for preparing drugs for treating genetic diseases.
DE69535719T2 FAS ANTIGEN BINDING LIGAND  
Novel human and murine proteins designated Fas ligand (Fas-L) bind to the cell surface protein known as Fas antigen. DNA sequences, expression vectors and transformed host cells useful in...
DE60133011T2 METHOD FOR PRODUCING disaccharide and trisaccharide C6-C12 FATTY ACID ESTERS WITH HIGH ALPHA CONTENT AND MATERIALS THEREOF  
The present invention provides disaccharide and trisaccharide C6 to C12 mixed fatty acid esters having a high alpha content. Yet still further, the invention provides chemical processes for the...
DE202007018725U1 Oligonucleotide probes and containing these diagnostic kits for the determination of linezolid resistance  
Oligonucleotide probe hybridizing specifically with ribosomal RNA of microorganisms, the specific ribosomal to an under hybridization conditions RNA of the microorganism, the induced by a...
DE60225299T2 Nucleophilic Fluorination TO SOLID PHASE  
The present invention relates to novel solid-phase processes for the production of radiolabelled tracers, in particular for the production of <18>F-labelled compounds which may be suitable for use...
DE602005005240T2 4'-C-substituted 2-halo adenosine derivatives  
The present invention provides a 4'-C-substituted-2-haloadenosine derivative represented by the following formula ÄIÜ, ÄIIÜ, or ÄIIIÜ: (wherein X represents a halogen atom, R<1> represents an...
DE60133102T2 FISCHIMPSTOFF AGAINST Piscirickettsia salmonis  
The present invention relates to a fish vaccine. More specifically the invention relates to a vaccine to protect salmon against infection by Piscirickettsia salmonis. The invention is based on or...
DE60038248T2 MONO- AND disaccharide  
The present invention relates to a novel family of monosaccharide derivatives and disaccharide derivatives and to methods of preparation thereof. The novel mono- and disaccharide derivatives have...
DE60038220T2 Chimeric antisense oligonucleotides AND ZELLTRANSFEKTIONS COMPOSITIONS THEREOF  
Chimeric oligonucleotide of the formula 5'-W-X<1>-Y-X<2>-Z-3', where W represents a 5'-O-alkyl nucleotide, each of X<1> and X<2> represented a block of seven to twelve phosphodiester-linked...
DE102005029811B4 Oligonucleotide arrays, methods for their use, and their use  
oligonucleotide arrays comprising at least two by at least one spacer linked hybridizable oligonucleotide as primer sequences, characterized in that the spacer is selected from functionalized...
DE60225141T2 METHOD FOR INCREASING THE IN VIVO EFFICACY OF Oligonucleotides AND IGNITION RESISTANCE IN MAMMALS  
The invention relates to the use of nucleotide substitutes for increasing the in vivo efficacy of nucleic acid molecules and also for inhibiting inflammation in mammals. More particularly, the...
DE60132986T2 COMPOUNDS AND METHODS FOR REDUCING CHOLESTEROL MIRROR WITHOUT INDUCTION hypertriglyceridemia  
This invention provides methods of lowering cholesterol, delaying the onset of atherosclerosis, or treating atherosclerosis in a mammal without inducing hypertriglyceridemia. These methods involve...
DE102005011003B9 Method and means for the differential diagnosis of thyroid tumors  
process for the differential diagnosis of thyroid tumors to differentiate of benign tumors to malicious Tumors wherein: 1) RNA is isolated from a tissue sample of the thyroid gland, 2.) in the...
DE69435075T2 IMMUNOGENIC CHIMERA COMPRISING nucleic acid sequences SIGNAL SEQUENCE PEPTIDES endoplasmic reticulum AND AT LEAST ANOTHER PEPTIDE CODING, THEIR USE IN VACCINES AND FOR THE TREATMENT OF DISEASES  
Immunogenic chimeric proteins comprising an endoplasmic reticulum signal sequence and at least one other peptide are disclosed. The invention relates to the design of vaccinia virus constructs...
DE102007038037A1 Eukaryotic promoters for gene expression  
The Invention provides promoters prepared from yeast Arxula adeninivorans which are nitrate inducible genes of nitrate reductase (AYNR1) Nitrite (AYNI1) or the nitrate transporter (AYNT1) descended.
DE60038038T2 phosphonate  
The present invention relates to phosphonate compounds, compositions containing them, processes for obtaining them, and their use for treating a variety of medical disorders, e.g., osteoporosis...
DE102004063099B4 A process for preparing Thiophenglycosidderivaten  
The present invention relates to a process for preparing thiophene-glycoside derivatives of the general formula (I)
DE69839133T2 Isolation of nucleic acids  
A method of extracting nucleic acids from blood comprises contacting blood cells, preferably after lysing with an activated solid phase at one pH to immobilise the nucleic acids and then removing...
DE60319103T2 SUBSTANCES FOR PREVENTION AND TREATMENT OF AUTOIMMUNE DISEASES  
A substance is disclosed for preventing, delaying the onset of or treating one or more than one autoimmune disease, the substance comprising a combination of a polynucleotide construct comprising...
DE60319083T2 PHARMACEUTICAL COMPOUND AND METHODS FOR TREATING HUMAN CARCINOMA USING ARGININE-WITHDRAWAL  
The present invention provides an isolated and substantially purified recombinant human arginase having sufficiently high enzymatic activity and stability to maintain Adequate Arginine Depletion...
DE19805822B4 11-acetyl-12,13-dioxabicyclo [8.2.1] tridecenon derivatives, processes for their preparation and pharmaceutical compositions containing them  
(2R,3S,4S,5R,6R,10R,11R)-2,4,6,8,10-Pentamethyl-11-acetyl-12 ,13- dioxabicyclo(8.2.1)tridec-8-en-1-one compounds are new. (2R,3S,4S,5R,6R,10R,11R)-2,4,6,8,10-pentamethyl-11-acetyl-12 ,13-...
DE102008028357A1 New Hybrid System for Brassica napus  
The present invention relates to a conditional kerngenisch inherited Male sterility system in Brassica napus. Embodiments of the present invention provide the (Male sterile) female line precursor...
DE102007035730A1 Determining linezolid-resistance in microorganism comprises contacting microorganism with oligonucleotide-probe that can bind to microorganism ribosomal RNA showing point mutation caused by linezolid-resistance and detecting microorganism  
Determination of linezolid-resistance in microorganisms present in a sample, comprises contacting the sample with at least an oligonucleotide-probe, which can bind under hybridization conditions...
DE69531678T3 REKOMBINATIE VIRUSES, THEIR PRODUCTION AND THEIR USE IN GENE THERAPY  
Recombinant viruses comprising a heterologous. DNA sequence coding for a lipase involved in lipoprotein metabolism. The invention also concerns the preparation and use in therapy of said...
DE60037938T2 ANTISENSE THERAPY FOR TRPM-2  
A method for treating an individual suffering from a cancer comprising administering to the individual i) a chemotherapeutic agent, and ii) one antisense oligonucleotide having nucleotides in the...
DE60036534T2 SOLID PHARMACEUTICAL FORMULATIONS BASED ON SULFOALKYLETHERN the cyclodextrin FOR DELAYED RELEASE  
An osmotic solid pharmaceutical formulation for the controlled diffusional and osmotic delivery of a therapeutic agent to an environment of use comprising: a core comprising a physical mixture of...
DE102007035250A1 A method for separating non-proteinaceous biomolecules, in particular nucleic acids from protein-containing samples  
The This invention relates to a process for isolating non-proteinaceous biomolecules, in particular nucleic acids, wherein on a solid phase, a protein degradation is carried out.
DE60224816T2 Subcellular targeting of therapeutic proteins  
Targeted therapeutics that localize to a specific subcellular compartment such as the lysosome are provided. The targeted therapeutics include a therapeutic agent and a targeting moiety that binds...
DE102007032799A1 New sugar-containing polypyridine metal complexes e.g. useful as fluorescence markers in biological systems or for treating abnormal cells  
Sugar-containing polypyridine metal complexes (I) are new. Sugar-containing polypyridine metal complexes of formula (I) are new. (L1 n)(L2 m)(L3 o)(L4 p)(L5 q)M (I) L1-L5 : ligands, at least one...
DE69839060T2 VEGI, AN INHIBITOR OF ANGIOGENESIS AND TUMOR GROWTH  
The present invention relates to a vascular endothelial cell inhibitor, VEGI, capable of inhibiting angiogenesis in cellular models and tumourigenesis in animal models, and methods of use.
DE69334201T2 Dominant-negative membrane-bound Flk-1 receptor of the vascular endothelial growth factor VEGF  
The present invention relates to the use of ligands for the Flk-1 receptor for the modulation of angiogenesis and vasculogenesis. The invention is based, in part, on the demonstration that Flk-1...
DE60132471T2 Modulation of immunostimulatory ACTIVITY OF immunostimulatory oligonucleotide analogs BY POSITION ELLE CHEMICAL CHANGES  
The present invention relates to immunostimulatory oligonucleotide compounds and their use as immunostimulatory agents in immunotherapy applications.
DE60224401T2 HEPATITIS C VIRUS POLYMERASE INHIBITORS WITH HETEROBICYLISCHER STRUCTURE  
An isomer, enantiomer, diastereoisomer or tautomer of a compound, represented by formula I: wherein: A is O, S, N R 1 , or C R 1 , wherein R 1 is defined herein; ----- represents either a single...
DE10319917B4 Process for the selective carbohydrate oxidation using a supported gold catalysts  
Selective oxidation of a carbohydrate (mixture) or composition containing a carbohydrates comprises reacting an aqueous solution of the carbohydrate or composition in presence of oxygen and a gold...
DE69738466T2 Streptococcus pneumoniae methionyl tRNA SYNTHETASE  
The invention provides metS polypeptides and DNA (RNA) encoding metS polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing...
DE602004011272T2 SPECIFIC ANTAGONIST BOTH e AND AS P-selectins  
Compounds and methods are provided for modulating in vitro and in vivo processes mediated by selectin binding. More specifically, selectin modulators and their use are described, wherein the...
DE602004010741T2 Using Monosachharidphosphaten to improve intestinal function  
The present invention relates to an alternative agent with vitamin D-like activity or an improving agent for age-related depression of intestinal function, comprising a sugar-phosphate ester or a...
DE60037514T2 AQUEOUS IMMUNOLOGICAL ADJUVANTZUSAMMENSETZUNGEN OFF monophosphoryl lipid A  
An aqueous adjuvant composition comprising an attenuated lipid A derivative and a non-immunostimulatory surfactant or surfactants enhances the immunological response in a warm blooded animal to a...
DE102007028030A1 Biosurfactants and their preparation  
The Invention relates to a process for Biotensidherstellung wherein biotensiderzeugende microorganisms in a growing medium be moved. It is provided that the growing medium used in excess and a...
DE60224400T2 HEPATITIS C VIRUS POLYMERASE INHIBITORS WITH HETEROBICYLISCHER STRUCTURE  
An isomer, enantiomer, diastereoisomer or tautomer of a compound, represented by formula I: wherein: A is O, S, N R 1 , or C R 1 , wherein R 1 is defined herein; ----- represents either a single...
DE602004010916T2 METHOD FOR LUNG hersel of 2 ', 3'-didehydro-2', 3'-dideoxynucleosides and 2 ', 3'-dideoxynucleosides  
A process for preparing 2',3'-didehydro-2',3'-dideoxynucleosides and 2',3'-dideoxynucleosides is described, which comprises the reductive elimination reaction of a compound of formula in which X,...
DE60132170T2 MODULATION BY CpG OLIGONUCLEOTIDES CAUSED BY IMMUNE STIMULATION POSITION CHANGES RELATED nucleosides  
The invention provides methods for modulating the immune response caused by CpG-containing oligonucleotides. The methods according to the invention enable both decreasing the immunostimulatory...
DE69334197T2 Helicobacter pylori cytotoxin used in vaccines and diagnostics  
Helicobacter pylori is known to cause or be a cofactor in type B gastritis, peptic ulcers, and gastric tumors. In both developed and developing countries, a high percentage of people are infected...