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DE102015216558A1 PROCEDURE AND TEST KIT FOR FAST ISOLATION OF NUCLEIC ACIDS BY SMOKE SURFACES  
The invention relates to a method for isolating nucleic acids from nucleic acid-containing samples, characterized in that free nucleic acids released by lysis are bound to a solid phase with a...
DE102014018527A1 CYCLO - NUCLEOSIDE  
The present invention relates to cyclo-nucleosides of the formula (I) where R is hydrogen, alkyl or acyl, R1 is hydrogen or alkyl, X is hydrogen or the radical OR and Y is oxygen or NH.
DE10328887B4 Alkaline protease  
Alkaline protease with a prepro sequence, the prepro sequence being a mutated sequence of the amino acid sequence of SEQ ID NO. 1 represents or an amino acid sequence with at least 80%, 87%, 90%,...
DE102015008631A1 Medicines for cancer therapy  
The present invention relates to novel chemical compounds, in particular benzophenone derivatives, which are suitable as active ingredients in the medicinal treatment of cancer.
DE202014010612U1 Double Run cassette  
Cassette (1) for synthesizing a plurality of batches of a [18F] -labelled positron emission tomography (PET) -Tracers, said cartridge comprising: (i) an anion exchange column (3, 4) for each of...
DE19858588B4 The dye-labeled oligonucleotide for labeling a nucleic acid molecule  
The dye-labeled oligonucleotide for labeling a a target sequence section comprising a nucleic acid molecule, wherein the dye-labeled oligonucleotide comprises the following components: a) - a loop...
DE102014013397A1 Perlenketten sequencing  
There will be described using labeled nucleotides, a method for sequencing nucleic acids. Firstly, the nucleotides on the ribose or deoxyribose may be labeled and be integrated by means of a...
DE102014112055A1 Di- and triphosphate drugs  
The invention relates to compounds that can be used as prodrugs, in particular nucleoside and triphosphate prodrugs, and a method for producing these compounds. The object of the present invention...
DE102014210662A1 Device and method for obtaining glycoglycerolipids and glycosphingolipids from lipoid phases  
The present invention relates to a device and method for the gentle and hydrolysis-free separation of glycoglycerolipids as well as glycoglycerolipids and glycosphingolipids from a lipoid phase...
DE102014208194A1 Purification of epidaunorubicin  
The present invention relates to a process for the purification of epidaunorubicin, in particular the removal of the impurity epi-feudomycin as occurs as a by-product in the biotechnological...
DE102014001464A1 RNAi technology  
Ribonucleic acids (RNAs) can be blocked by small inhibitory RNAs. In this way, genes off. This mechanism known as RNA interference was first described by Andrew Fire and Craig Mello. For the...
DE112013004650T5 Multiplexpyrosequenzierung using nichtinterferierender, noise-terminating Polynukleotididentifikationstags  
The present disclosure relates generally to a multiplexing method for analyzing samples, comprising the Polynukleotidamplifikation to production of amplified products, wherein one or more target...
DE102013111487A1 The bispecific antibody fragment and pharmaceutical combination preparation with such a  
The invention relates to a bispecific antibody fragment (10) with a first detection point (12) and at least a second detection point (14), which specifically recognize each at least one structure...
DE19547958B4 Anthracycline derivatives  
Anthracycline analog of formula A wherein R1 is a hydrogen atom or a hydroxy or methoxy group; R2 and R3 are each hydroxyl groups or one of R2 and R3 is a hydroxy group and the other is a hydrogen...
DE102013006487A9 Iterative assembly and disassembly of predetermined, artificial DNA constructs and the specific exchange of functional genetic elements  
A variety of assembly methods for higher-order DNA constructs for the integration of molecular function have been described and also patented. There are no uniform concepts for the targeted...
DE102013105144A1 The pharmaceutical combination product with an anti-idiotype antibody fragment  
The invention relates to a pharmaceutical combination preparation (10), in particular to suppression of an immune response, preferably a humoral immune response against a therapeutic organism...
DE112004000265B4 Novel photolabile protecting groups for improved processes for the production of oligonucleotide arrays  
Use of a compound having the general formula (1): in which R1 Is COOY, where Y is selected from the group consisting of an optionally substituted alkyl group having up to 10 carbon atoms on the...
DE102013006487A1 Iterative assembly and disassembly of predetermined, artificial DNA constructs and the specific exchange of functional genetic elements  
A variety of assembly methods for higher-order DNA constructs for the integration of molecular function have been described and also patented. There are no uniform concepts for the targeted...
DE112012003416T5 A process for the preparation of 2- (4-Methoxycarbonylpyrazol-1-yl) adenosine and 2- (4-ethoxycarbonyl-1-yl) adenosine  
A process for the preparation of 2- (4-Methoxycarbonylpyrazol-1-yl) adenosine of the formula Ia and 2- (4-ethoxycarbonyl-1-yl) adenosine of the formula Ib by reaction of 2-Hydrazinoadenosin of...
DE102012221519A1 Process for the isolation of rhamnolipids  
The invention relates to a method for isolating rhamnolipids
DE10362249B4 C1-selective oxidation of oligosaccharides and the use of a carbon supported gold catalyst for this oxidation  
Process for the selective oxidation of the C1-aldehyde group of a used as starting material oligosaccharide, oligosaccharide mixture or an oligosaccharide or composition containing an...
DE102012110740A1 Preparing carbohydrate-analogs from five- or six-membered ring glycals, comprises reacting glycal by addition of ketene to corresponding cycloketone, converting cycloketonic to ketoxime, and converting ketoxime in lactam by rearrangement  
Preparing carbohydrate-analogs from five- or six-membered ring glycals, comprises: (a) reacting the glycal by the addition of ketene to the corresponding cycloketone; (b) converting cycloketonic...
DE112012003470T5 A process for preparing 2- [4 - [(methylamino) carbonyl] -1-H-pyrazol-1-yl] adenosinmonohydrat  
A process for preparing 2- [4 - [(methylamino) carbonyl] -1-H-pyrazol-1-yl] adenosinmonohydrat of the formula I by reaction of 2- (4-Methoxycarbonylpyrazol-1-yl) adenosine of the formula III with...
DE102012110664A1 In coatings, bonding agents or adhesives for oxide surfaces usable peptides  
The present invention relates to peptides, particularly dodecapeptides containing coating agents, adhesion promoters or adhesives for oxide surfaces, a multilayer composite or a coated substrate...
DE102006053385B4 Enterococcus faecalis antigen  
Enterococcus faecalis strain type 5 antigen, which comprises at least one disaccharide unit, which has the following formula: where R1 OH is X = O, Y = O and CA Lactyl is.
DE102012216955A1 A method comprising a continuous crystallization of isomaltulose  
The invention provides methods comprising a continuous crystallisation of isomaltulose.
DE102010006245B4 Mayamycin compounds, processes for their preparation, their uses and cosmetic product containing them  
Connection of the general structure in which R is a hydrogen atom (H) or an unsubstituted, monosubstituted or polysubstituted C1-C20-Alkyl, where the alkyl can be straight, branched, cyclic or...
DE102012103730A1 Detection method for Mycobacterium avium ssp. paratuberculosis  
The present application relates to a method for the specific detection and optionally quantification of Mycobacterium avium ssp. paratuberculosis (MAP) in a sample of an individual. According to...
DE102011120550B4 Compositions, methods and kits for the detection of adenovirus nucleic acids  
A method for specifically detecting an adenovirus target nucleic acid in a sample, comprising the steps: (a) contacting a sample suspected of containing at least one adenovirus nucleic acid with...
DE102008025328B4 Compositions and methods for the amplification of HI viruses by means of multiplex-PCR in multiple genome areas  
A method of detecting HIV-1 and HIV-2 in blood-derived samples, comprising a) providing samples derived from blood, b) concentrating the blood-derived samples, c) extracting the viral nucleic...
DE102012101557A1 Use of microRNAs or genes as markers for the identification, diagnosis and therapy of individual non-ischemic cardiomyopathies or memory diseases of the heart  
The invention relates to the use of certain microRNAs and / or genes both individually and in combination in the form of profiles as markers for the identification of individual non-ischemic...
DE102007010252B4 Control genes for normalizing gene expression analysis data  
Control gene set for the normalization of gene expression analysis data from blood samples of a patient with diseases with a systemic immune reaction, in particular SIRS, sepsis, severe sepsis,...
DE102011121238A1 SINGLE DOMAIN ANTIBODIES AGAINST CLOSTRIDIUM DIFFICILE TOXINE  
The invention relates to antigen-binding polypeptides which comprise the CDR1, CDR2 and CDR3 region of a VHH domain of a camelide heavy chain antibody. The polypeptides bind specifically in the...
DE102011056679A1 A process for the acid-catalyzed oligomerization of mono- or di-saccharides  
There is a process for the acid-catalyzed oligomerization of mono- and / or di-saccharides is disclosed wherein the mono- or Disa ccharide in the presence of inorganic and / or organic acid to a...
DE102006020463B4 A method of removing nucleic acids from a fluid, method for producing adsorber and using Membranadsorbermaterial-blend  
A method for at least partial removal of nucleic acids (18) from a liquid (12), as they occur during the digestion of microorganisms such as bacteria, yeasts, fungi, protozoa or eukaryotic cell...
DE69132920C5 Method for the production of filamentous bacteriophage antibody-presenting by use of phagemids and the bacteriophage produced Daduchus  
A filamentous bacteriophage particle, on whose surface a binding molecule is presented, which is a Fab or single-chain Fv antibody molecule comprising a binding domain capable of binding to the...
DE4321904B4 A process for chromatographic purification and separation of Nucleinsäuregemischen  
A process for chromatographic purification and separation of Nucleinsäuregemischen from biological sources such as cell cultures, tissues, body fluids, microorganisms or viruses to be separated by...
DE102011055247A1 Multianalyt reporter system  
The invention relates to a mediator probe for binding to a target molecule and / or a detection molecule comprising a probe region and a mediator-region as well as a method for detecting at least...
DE102011117874A1 New dimethyl sulfoxide solvate hydrate of erythromycin useful for combating germs e.g. Bacillus anthracis and Streptococcus and treating lower respiratory tract disorder e.g. bronchitis, pneumonia and whooping cough  
Dimethyl sulfoxide (DMSO) solvate hydrate of erythromycin (I) is new. Dimethyl sulfoxide (DMSO) solvate hydrate of erythromycin of formula (E.xDMSO.yH 2O) (I) is new. E : erythromycin; x :...
DE4420157B4 New growth / differentiation factor of the TGF-β family  
Use of a pharmaceutical composition containing a protein which is encoded by a DNA sequence which (a) nucleotides 1783-2142, 640-2142 or 1837-2142 of SEQ ID NO: 1, (b) one of the sequences from...
DE102011054413A1 Anti-idiotype monoclonal antibody ganglidiomab  
The present invention relates to an anti-idiotypic antibody that mimics the disialoganglioside GD2. GD2 is expressed on neuroectodermal tumors. Also included is a corresponding hybridoma cell line...
DE102011113652A1 Crystallization of idarubicin  
The patent application relates to a method for preparing crystalline idarubicin hydrochloride comprising the steps of (I) preparing a mixture comprising (a) idarubicin hydrochloride, (b) at least...
DE102011082891A1 Preservative containing glycolipids  
The invention relates to a preservative containing a glycolipid of the formula (I): in which R1 H or COCH3 means and R2 is the same or different and H or means, where n is 1, 2 or 3 and R3 is...
DE102011112496A1 4-methylcatechol derivatives and their use  
The invention relates to phenoxy derivatives with glycosidically bound sugar residues, pharmaceutical compositions with such compounds, uses of such compounds and compositions and processes for...
DE102011107197A1 Use of a crosslinked sulfonated polymer to separate macromolecules from a solution derived from a biological source, where the crosslinked sulfonated polymer is optionally bonded to a scaffolding containing a sulfonated aryl moiety  
Use of a crosslinked sulfonated polymer for the separation of macromolecules from a solution derived from a biological source, is claimed, where the crosslinked sulfonated polymer is optionally...
DE102011118022A1 Antibodies to the prostate specific antigen stem cells and the use thereof  
The invention relates to recombinant to prostate-specific stem cell antigen (PSCA) antibody binding. The antibody of the invention comprises complementarity determining regions (CDR) having the...
DE102011056606B3 Method for the electrochemical detection of nucleic acid oligomer hybridization events  
A method for the electrochemical detection of nucleic acid oligomer hybridization events comprising the steps is described a) providing a modified surface, the modification consisting in the...
DE102011103751A1 Crystallization of epirubicin hydrochloride  
The invention relates to crystalline epirubicin hydrochloride and a method for its production. The method for producing crystalline epirubicin hydrochloride comprises the steps (a) providing...
DE69314239C5 Stereoselective glycosylation method  
Process for the synthesis of a nucleoside of the formula enriched in β-anomer which, if appropriate in a suitable solvent, involves carrying out a nucleophilic SN2-Substitution of a sulfonyloxy...
DE602004036672C5 Nucleic acid-based emulsion beads  
Method for enriching an amplicon comprising: (A) distributing an amplification solution, which comprises a sufficient mixture of reagents that are required for carrying out an amplification...