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DE69836809T2 Improvements in the adapters based sequence analysis  
An improvement in adaptor-based sequence analysis is provided that addresses the problems created by self-ligation of target polynucleotides that have complementary ends. The improvement includes...
DE69836587T2 NUCLEIC COLLECTION  
This invention is directed to a process for irreversibly binding nucleic acid to solid phase and corresponding processes for the utilization thereof. Nucleic acid is bound to solid phase matrixes...
DE69636752T2 HUMAN GROWTH FACTOR 2 SPECIFIC FOR VASCULAR ENDOTHELIAL  
Disclosed is a human VEGF2 polypeptide and DNA(RNA) encoding such VEGF2 polypeptides. Also provided is a procedure for producing such polypeptide by recombinant techniques and antibodies and...
DE60310944T2 NEW FORMS of interfering RNA MOLECULES  
The present invention is related to a ribonucleic acid comprising a double stranded structure whereby the double- stranded structure comprises a first strand and a second strand, whereby the first...
DE60309779T2 A process for producing cellulose acetate  
A process for manufacturing xyloligosaccharides comprises: steaming a corncob meal under conditions of a temperature of 150 to 250 DEG C and a pressure of 20 to 29 Mpa; filtering the steamed...
DE602004003948T2 PRODUCING 2-18F-2-deoxy-D-GLUCOSE BY SOLID PHASE SYNTHESIS  
The invention relates to a compound of formula (I): wherein P1, P2, P3, and P4 are each independently hydrogen or a protecting group; and n is an integer of from 2 to 20 and to the use of such...
DE602004003809T2 NEW 14- AND 15-PRONGED RING COMPOUNDS  
The present invention relates to 14- or 15-membered macrolides substituted at the 4'' position of formula (I) and pharmaceutically acceptable derivatives thereof, to processes for their...
DE602004003755T2 Thermostable Taq Polymerase fragment  
It was found that a fragment of native Thermus aquaticus DNA polymerase (TaqWT) lacking 288 N-terminal amino acids (Taq DELTA 288) possesses an increased thermostability over TaqWT, Taq DELTA 279,...
DE60124411T2 IONIC LIQUIDS AND THEIR USE AS SOLVENTS  
Ionic compounds with a freezing point of up to 100° C. are formed by the reaction of an one amine salt of formula (I) R1R2R3R4N+X-, such as choline chloride with an organic compound (II) capable...
DE60032470T2 CURE THE SULFOPYRANOSYLACYLGLYCEROLDERIVATE CONTAIN  
A medicament containing at least one compound selected from the group consisting of compounds represented by General formula (1): wherein R101 represents an acyl residue of an unsaturated higher...
DE19811540B4 Apicularen A, processes for its preparation and cytostatic agent with apicularen A  
apicularen A of formula
DE69934227T2 On beta-arabinose and its analogues based antisense oligonucleotides  
The present invention relates to modified oligonucleotide therapeutic agents to selectively prevent gene transcription and expression in a sequence-specific manner. In particular, this invention...
DE69836697T2 New 3.6-hemi-9a-Azalidklasse  
Novel macrolide antibiotics (I) comprise 3,6-hemiketals of 9a-azalides. Macrolides of formula (I) and their addition salts with inorganic or organic acids are new. [Image] R1OH or L-cladinosyl of...
DE60310525T2 ULTRAVIOLET LIGHT TO LIGHT ACTIVATED AT gene transduction gene delivery  
This application relates to a method for increasing transduction of a vector into a cell in vitro, said method comprising exposing a cell to UV light having a wavelength of 320 to 400 nm, thereby...
DE60124594T2 macrolide antibiotics  
The present invention relates to 11,12 gamma lactone ketolides of formula (I) wherein R, R1, R2, R3 are as defined herein and pharmaceutically acceptable salts and solvates thereof, to process for...
DE60122791T2 A process for preparing clarithromycin with non-pharmaceutical grade  
High purity clarithromycin of Form II crystals can be easily prepared in a high yield by a process comprising the steps of: protecting the 9-oxime hydroxy group of erythromycin A 9-oxime or a salt...
DE10228785B4 Detection of toxic algae  
oligonucleotide characterized in that one of the sequences SEQ ID No.1 to 19 exhibits.
DE69836428T2 carcinostatic SUBSTANCES  
Agents capable of inhibiting the proliferation of cancer cells and cancers in the tissues therearound or unaffected tissues. Specifically, carcinostatic agents containing as the active ingredient...
DE69836395T2 Primers for the detection of HIV-1  
The present invention provides improved primers for the polymerase chain reaction (PCR) amplification of a nucleic acid sequence from the gag gene of the human immunodeficiency virus type 1...
DE60216468T2 KOMBINATIONSOLIGOMERE RELATED METHOD, KITS AND COMPOSITIONS  
This invention pertains to the field of combination oligomers, including the block synthesis of combination oligomers in the absence of a template, as well as related methods, kits, libraries and...
DE60216447T2 DEVICE AND METHOD FOR PROCESSING BIOLOGICAL SAMPLES  
Compositions containing a near-IR dye and greater than about 0.5 wt-% of a surfactant selected from the group of a nonionic surfactant, a zwitterionic surfactant, and a mixture thereof, and...
DE602005001414T2 Caging Groups  
The present invention relates to novel nucleoside derivatives of general formula (I) wherein R<1> = H, halogen, NO2, CN, OCH3, an alkyl, alkoxy or alkoxyalkyl residue having 1 to 4 C atoms,...
DE60035107T2 SPLICE VARIANTS OF LIM MINERALIZATION PROTEIN  
The present invention is directed to isolated nucleic acid molecules that encode LIM mineralization protein, or LMP. The invention further provides vectors comprising nucleotide sequences that...
DE69933186T2 Method for purifying and manipulating nucleic acid using paramagnetic particles  
The present invention relates to a composition which is useful for the reversible binding of a nucleic acid molecule. The composition, which may be packaged in a kit, includes a paramagnetic...
DE69736950T2 TRICYCLIC piperdinyl DERIVATIVES SUITABLE AS farnesyl PROTEIN TRANSFERASE INHIBITORS  
Novel tricyclic compounds of formula (1.0) or a pharmaceutically acceptable salt or solvate thereof, wherein: one of a, b, c, and d represents N or NR<9>, wherein R<9> is O-, -CH3 or -(CH2)nCO2H...
DE69736699T2 A method for producing L-lysine  
A recombinant DNA autonomously replicable in cells of coryneform bacteria, comprising a DNA sequence coding for an aspartokinase in which feedback inhibition by L-lysine and L-threonine is...
DE69229556T3 METHOD FOR SELECTION OF GENETICALLY TRANSFORMED CELLS AND ENSURE SUITABLE COMPOUNDS  
A method for selecting from a population of cells genetically transformed cells into which a desired nucleotide sequence has been introduced, wherein in the transformed cells the desired...
DE60313855T2 GROWTH-REGULATING GENE  
The application discloses a new family of proteins, namely the epsin like proteins (ELP). Said proteins comprise an ENTH domain (Epsin NH2 Terminal Homology domain) and have growth inhibiting...
DE60306750T2 PEPTIDE FRAGMENT OF LIGAND BINDING POCKET OF ESTROGEN RECEPTOR 3 (ERR3) CRYSTAL STRUCTURE THEREOF, AND THEIR USE  
The present invention relates to the identification of novel biologically active compounds having an agonist or an antagonist effect on the transcriptional-activating activity of the...
DE60216440T2 Immobilization of Oligonucleotides ON SOLID SUPPORT  
A solid support bound polynucleotide, preferably a 3'-O- or 5'-O-substituted polynucleotide, is disclosed. The polynucleotides are of formula: wherein Q is a substantially pure polynucleotide,...
DE60216416T2 METHOD FOR DETECTION OF chloral hydrate in dichloroacetic  
Methods for detecting chloral hydrate in dichloroacetic acid are described.
DE60214412T2 Simplified SARCODICTYN DERIVATIVES AS ANTI-TUMOR AGENTS  
There are provided sarcodictyin derivatives or pharmaceutically acceptable salts thereof, which are characterized by a simplified chemical structure and have anti-tumor activity. A process for...
DE60024660T4 HUMAN RNASE H AND RELEVANT oligonucleotide compounds  
The present invention provides oligonucleotides that can serve as substrates for human Type 2 RNase H. The present invention is also directed to methods of using these oligonucleotides in...
DE69933738T2 Composition containing trehalose and amino acids  
An amino acid-sugar composition comprising an amino acid composition which comprises proline, alanine, glycine, valine, threonine, leucine, histidine, lysine, isoleucine, arginine, phenylalanine,...
DE69636563T2 Include matrices for sequencing nucleic acids in the sample mixtures at intertwined polymer networks  
A capillary electrophoresis system and method of electrokinetically loading a capillary electrophoresis sample into a separation medium in a capillary tube in which an entangled polymer matrix is...
DE60309817T2 Multi-purpose primers and probes for improved hybridization assays by destruction of secondary structures  
A kit for determining the genotype of an individual by amplifying a target nucleic acid sequence in a target molecule, wherein the target nucleotide sequence contains a site of interest proximal...
DE602004003389T2 METHOD FOR PRODUCING 4'-AZIDONUKLEOSIDDERIVATEN  
A process for the preparation of a 4'-azido-2',3',5'-triacyl-nucleoside compound (I; B=B1; R<1 >is R<1a>CO- and R<2 >is R<2a>CO-) or a 4'-azidonucleoside compounds (I; B is B1 or B2 and R<1 >and...
DE60124678T2 PROTEIN SCAFFOLDS FOR ANTIBODY mimetics AND OTHER BINDING PROTEINS  
Disclosed herein are proteins that include a fibronectin type III domain having at least one randomized loop. Also disclosed herein are nucleic acids encoding such proteins and the use of such...
DE60123277T2 macrolide antibiotics  
11,12 gamma lactone ketolides of the following formula: and pharmaceutically acceptable salts and solvates thereof, wherein R, R1, R2, and R3 are as described herein. The disclosure also relates...
DE60031957T2 COMBINATORIAL COMPLEX CARBOHYDRATE LIBRARIES AND METHOD FOR PRODUCING AND USE THEREOF  
The present invention concerns a carbohydrate library comprising a plurality of carbohydrate structures each being attached at a specific and addressable location of an array, whereas a...
DE202007003784U1 Apparatus for the purification of biomolecules  
device for the purification of biomolecules having by adsorptive separation in a a flat adsorbent (6) Chromatography module (2), the housing (3) at least one inlet (4) and at least one outlet (5)...
DE102006011077A1 A method for degradation of cellulose with nucleophiles  
The This invention describes a method for degradation of cellulose, by dissolving cellulose in an ionic liquid and with a nucleophile treated.
DE102006011076A1 Degradation of poly-, oligo- or di-saccharide or derivative e.g. partial degradation of cellulose for fiber or film production or complete degradation to glucose involves heating solution in ionic liquid e.g. quaternary ammonium compound  
Process for degradation of poly-, oligo- or di-saccharides or their derivatives comprises dissolving the material in ionic liquid(s) and treated at elevated temperature, optionally with addition...
DE102006011075A1 Process for the degradation of cellulose in solution  
The This invention describes a method for degradation of cellulose, by dissolving the cellulose in an ionic liquid and with an acid, optionally the addition of water, treated.
DE102004028241B4 New fluoroglycoside derivatives of pyrazoles, pharmaceutical compositions containing them and the preparation of these drugs  
The invention relates to substituted fluoroglycoside derivatives of pyrazoles of formula (I) as further defined in the specification, to the physiologically compatible salts thereof, to a method...
DE69736667T2 METHODS FOR THE DETECTION AND AMPLIFICATION nucleic acid sequences CONSUMPTION OF MODIFIED Oligonucleotides WITH INCREASED GOAL MELTING TEMPERATURE (TM)  
The present invention concerns oligonucleotides containing one or more modified nucleotides which increase the binding affinity of the oligonucleotides to target nucleic acids having a...
DE69434875T2 BMP-11 compositions  
Purified BMP-11 proteins and processes for producing them are disclosed. Recombinant DNA molecules encoding the BMP-11 proteins arc also disclosed. The proteins may be useful in regulating...
DE60311941T2 TANKS FOR THE POLYMERASE CHAIN ​​REACTION AND METHOD FOR PRODUCING  
The present invention provides a kit employed for polymerase chain reaction. The kit has a cavity and a flow channel on a substrate. The flow channel is separated from the cavity by at least a...
DE60216601T2 WITH AN ALUMINIUM SALT TREATED ANTHOCYANINDERIVATE AS FOOD COLOURS  
A process for modifying the taste and/or odour properties of a food colouring substance having unpleasant taste and/or odour properties is disclosed. Secondly, there is provided a process for...
DE60214778T2 METHOD FOR ISOLATION OF eupalitin (3-O-BETA-D-GALACTOPYRANOSIDE) OFF Boerhavia diffusa  
The present invention relates to a process of isolation of bioactive eupalitin (3-O-O-D-galactopyranoside) of formula 1 possessing anti-osteoporosis activity by extraction of powdered leaves of...