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DE60033927T2 L-RIBO-LNA ANALOG  
Provided are L-ribo bicyclic nucleotide compounds as well as syntheses of such compounds. The nucleoside compounds of the invention are useful in forming oligonucleotides that can produce...
DE69837208T2 NORMALIZED NUCLEIC LIBRARIES AND METHOD THEREOF  
The present invention relates generally to methods for producing normalized nucleic acid libraries in which each member of the library can be isolated with approximately equivalent probability. In...
DE69837007T2 USE OF 9A-azalides AS ANTIMICROBIAL AGENTS FOR ANIMAL  
9a-Azalides are useful in the treatment and prevention of bacterial respiratory and enteric infections in livestock animals, particularly in cattle and swine.
DE69636937T2 BY TRANS-CLEAVAGE GOT THERAPEUTIC molecules  
The molecules and methods of the present invention provide a means for in vivo production of a therapeutic molecule in a selected subset of cells. The pre-therapeutic molecules of the invention...
DE69334111T2 CD27 Ligand  
CD27 ligand (CD27L) polypeptide and DNA sequences, vectors and transformed host cells useful in providing CD27L polypeptides. The CD27L polypeptide binds to the CD27 receptor.
DE60311649T2 C-aryl glucosides SGLT2 inhibitors and method  
An SGLT2 inhibiting compound is provided having the formula A method is also provided for treating diabetes and related diseases employing an SGLT2 inhibiting amount of the above compound alone or...
DE60220024T2 PYRIMIDINNUKLEOSIDDERIVATKRISTALL  
The present invention provides crystalline forms of a pyrimidine nucleoside derivative having excellent anti-tumour activity. ÄSolutionÜ Crystalline forms of compound of the following formula (I):
DE60218503T2 USE OF PEPTIDE VECTORS TO IMPROVE THE IMMUNE RESPONSE AGAINST ANTIGENS  
The invention relates to conjugates of an antigen coupled to a linear derivative of a beta-stranded antibiotic peptide, which are useful for immunogenic agents to enhance a CTL response. Two...
DE60218165T2 Lipolysis for reducing body weight and medical application  
New lipolysis accelerator comprises a dihydroxyphenyl derivative (I). New lipolysis accelerator comprises a dihydroxyphenyl derivative of formula (I); [Image] Z : CHOHCH 3or COCH 3; R 1, R 2H or...
DE602004007662T2 RAPAMYCIN-carbohydrate DERIVATIVES  
This invention provides modified rapamycins that have specific monosaccharide(s), oligosaccharide(s), pseudosugar(s) or derivatives thereof attached through a linker to create rapamycin...
DE602004006133T2 NEW GALACTOOLIGOSACCHARIDZUSAMMENSETZUNG AND PREPARATION THEREOF  
Novel strains of Bifidobacterium hifidum capable of producing a novel galactosidase enzyme activity that converts lactose to a novel mixture of galactooligosaccharides. The mixture of...
DE69837295T2 Succinic acid ester of probucol for inhibiting the expression of VCAM-1  
This invention is in the area of methods and compositions for the inhibition of the expression of VCAM-1 and, in particular, for the treatment of diseases mediated by VCAM-1, including...
DE69736637T2 MULTIPLEX AMPLIFICATION SHORT TANDEM REPEAT LOCI  
The invention is directed to the simultaneous amplification of multiple distinct genetic loci using PCR or other amplification systems to determine in one multiplex reaction the alleles of each of...
DE69535405T2 Angiostatin AND METHOD FOR USE FOR THE AVOIDANCE OF ANGIOGENESIS  
The present invention comprises an endothelial inhibitor and method of use therefor. The endothelial inhibitor is a protein isolated from the blood or urine that is eluted as a single peak from...
DE69535365T2 PARALLEL SELEX METHOD  
This invention disclosures a method for coevolving products from two or more reactants, along with the nucleic acid that can facilitate the reaction for making the products. The invention further...
DE69434908T2 RECEPTOR ON THE SURFACE OF ACTIVATED T CELLS: ACT4  
The invention provides purified ACT-4 receptor polypeptides, antibodies against these polypeptides and nucleic acids encoding ACT-4 receptor polypeptides. Also provided are methods of diagnosis...
DE69233676T2 Receptor protein tyrosine kinase (FLK-1)  
isolated mammalian nucleic acid molecules encoding receptor protein tyrosine kinase expressed in primitive hematopoietic cells and not expressed in mature hemotopoietic cells are provided. Also...
DE60126416T2 TREATING ARTHRITIS AND RELATED COMPOSITIONS  
A 2-glucosamine derivative of the general formula (I):wherein R is an alkyl radical of the general formula CnH2n+1 and n is selected from 2-12; and pharmaceutically acceptable salts, esters and...
DE60126319T2 Immobilization of aminated BIOPOLYMERS ON SUBSTRATES BY DIRECT ADSORPTION  
An assay article for detection biopolymers contained in a sample is described. The assay article includes a substrate and a biopolymer directly adsorbed on the surface of the substrate. A...
DE60125212T2 Use of Aivlosin for the treatment and prevention of Lawsonia infections in pigs.  
The use of AIVLOSIN, as such or as a pharmaceutically acceptable (non-toxic) derivative such as an acid addition salt, for the preparation of a veterinary medicament for the treatment and...
DE60032235T2 Ribonukleinsäurederivate  
Provided is a preparative method for isolating RNA comprising an oligo-or polynucleotide from a sample, which method comprises: (a) treating the sample with a reactant capable of covalently...
DE69935248T2 DNA PROTEIN MERGERS AND APPLICATIONS OF THE SAME  
Disclosed herein are molecules that include a deoxyribonucleic acid (DNA) covalently bonded to a protein and uses thereof.
DE69737432T2 Farnesyl diphosphate synthase  
A mutant prenyl diphosphate synthase capable of synthesizing prenyl diphosphates, shorter than those synthesized by the original enzyme, by modifying the amino acid sequence in and upstream of the...
DE69535376T2 EXPRESSION VECTOR ABACAVIR  
The present invention is directed to alphavirus expression vectors comprising at least part of an alphavirus genome and heterologous RNA inserted downstream of an alphavirus base sequence having...
DE60126762T2 Combinatorial production of nucleotide and nucleoside (XITP) analogs  
Hydrazide-substituted nucleoside or nucleotide analogs (I) are new. Nucleoside or nucleotide analogs of formula (I) are new. [Image] R 1H; mono-, di- or tri-phosphate group; or protective group...
DE60033851T2 Biomolecules MULTIPLE CONNECTION SECTIONS FOR BINDING TO A SUBSTRATE SURFACE  
Biomolecules are provided having multiple binding sites for attachment to a substrate surface. The multiple attachment sites may be produced directly on the biomolecule or through use of branched...
DE60033648T2 mounted on a surface polyfunctional polymer networks for sensor chips  
The invention relates to polyfunctional polymer networks comprising an assembly of cross-linked polymer subchains attached to a surface, with each polymer subchain comprising a multitude of...
DE102006020885A1 Inserting a tag sequence into a nucleic acid comprises using an anchor oligonucleotide comprising a hybridizing anchor sequence and a nonhybridizing tag-template sequence  
Inserting a tag sequence into a nucleic acid comprises hybridizing an anchor sequence of an anchor oligonucleotide to a sequence segment of a template nucleic acid and synthesizing a new nucleic...
DE69935250T2 OLEANDOMYCIN DERIVATIVES  
The invention relates to novel compounds from the class of the macrolide antibiotic oleandomycin of the general formula (I)whereinR1 has the individual meaning of -CH2CH3 group, of a fragment of...
DE69736067T9 NEW cryptophycin derivatives as antineoplastic agents  
The invention provides novel cryptophycin compounds which can be useful for disrupting the microtubulin system, as anti-neoplastic agents, and for the treatment of cancer. The invention further...
DE69636936T2 FACTOR-1, inducible by hypoxemia, AND METHOD FOR APPLICATION  
The purified and characterization of hypoxia-inducible factor 1 (HIF-1) is described. HIF-1 is composed of subunits HIF-1± and HIF-1². Purified HIF-1± polypeptide, its amino acid sequence and...
DE60128395T2 NUTRITIONAL COMPOSITION WITH HEALTH PROMOTING EFFECT CONTAINING OLIGOSACCHARIDES  
A nutritional composition having beneficial effect in the gastrointestinal tract, especially an anti-adhesion effect on pathogenic micro-organisms and a bifidogenic effect, contains non-digestible...
DE102006019480A1 Use of gene expression profiles to detect any postoperative tissue incompatibility reactions after liver transplantation  
Gene expression profiles obtained from a patient sample in vitro are used to detect any postoperative tissue incompatibility reactions after liver transplantation. An independent claim is also...
DE10014639B4 cDNSen with a coding of enzymes for fructan synthesis with a low-temperature expression as well as methods for their isolation  
process to isolate a cDNA that encodes an enzyme for fructan synthesis, which is active at a temperature of about 4 ° C, characterized by the following steps: - Cold-conditioning a winter wheat...
DE69434839T2 Transferrin receptor GENES FROM HAEMOPHILUS  
Purified and isolated nucleic acid is provided which encodes a transferrin receptor protein of a strain of Haemophilus or a fragment or an analog of the transferrin receptor protein. The nucleic...
DE69334071T2 PROSTATE SPECIFIC MEMBRANE ANTIGEN  
This invention provides for an isolated mammalian nucleic acid molecule encoding a mammalian prostate-specific membrane antigen. This invention provides for nucleic acid probes which specifically...
DE69233669T2 BACTERIAL nitroreductase FOR REDUCING CB1954 AND ANALOG THEREOF cytotoxic FORM  
The invention provides a nitroreductase, obtainable from a bacterium having the following characteristics as exemplified by examples isolated from Escherichia coli B and Bacillus...
DE69133555T2 POLYPEPTIDES IN expressing the GLYKOPEPTIDANTIBIOTIKARESISTENZ INCLUDED ARE  
New polypeptide compsn. (A) comprises at least one protein (I) (or part of it) involved in resistance to glycoprotein antibiotics. (I) are identified by reference to a 10851 base DNA sequence...
DE602004003907T2 Avermectin and AVERMECTINMONOSACCHARIDDERIVATE IN THE 4 '' - or 4 position SUBSTITUTED ARE AND PESTICIDES PROPERTIES HAVING  
What is described are a compound of the formula (I) Wherein U is —N(R2)OR3 or —N+(O−)═C(RE)RZ); n is 0 or 1; X—Y is —CH═CH— or —CH2—CH2—; R1 is C1-C12alkyl, C3-C8cycloalkyl or C2-C12alkenyl; R2...
DE60125154T2 TEILDESULFATIERTE GLYKOSAMINOGLYKANDERIVATE WITH anti-angiogenic ACTIVITY AND WITHOUT anticoagulant EFFECT  
Partially desulfated glycosaminoglycan derivatives are described, particularly heparin, and more particularly formula (I) compounds where the U, R and R1 groups have the meanings indicated in the...
DE102007018551A1 Preparing gemcitabine comprises reducing a dihydro-furan-2-one compound to give a furan compound, activating the hydroxyl group and reacting with a protected cytosine to give a protected nucleoside and terminal protection of the nucleoside  
Preparation of gemcitabine comprises reducing a dihydro-furan-2-one compound (16A) to give a furan compound (19), activating the hydroxyl group by converting into a sulfonate (mesylate), reacting...
DE102006017492A1 Drug fixation on polymer surfaces  
Of the The present invention relates to compounds according to the general Formula 1, where R1. R2, R3, R4, R5, R6. R7, R8th, R9 and R10 independently selected are selected from the group...
DE69636734T2 Nucleosides WITH ANTI-HEPATITIS B VIRUS EFFECTIVENESS  
A method for the treatment of a host, and in particular, a human, infected with HB V is provided that includes administering an HBV-treatment amount of the stabilized nucleotide of a nucleoside...
DE69636720T2 THE fibroblast growth factor homologous FACTOR-1 (FHF-1) AND METHODS FOR ITS USE  
A novel protein, fibroblast growth factor homologous factor-1 (FHF-1), the polynucleotide sequence encoding FHF-1, and the deduced amino acid sequence are disclosed. Also disclosed are diagnostic...
DE69434890T2 CLONING AND RECOMBINANT PRODUCTION OF vespid venom HYALURONIDASE AND ON THE BASIS OF IMMUNOLOGICAL THERAPIES  
The present invention is directed to nucleic acids encoding vespid venom enzymes, or fragments thereof, recombinant vectors comprising such nucleic acids, and host cells containing the recombinant...
DE69334102T2 Arrangement for regulating the cytokine  
Substances comprising a N-sulfated or N-acetylated or non-sulfated N-acetylated 4-deoxy-4-en-iduronoglucosamine in substantially purified form, including compositions containing same and their...
DE60217465T2 Nucleoside AS INHIBITORS OF RNA-DEPENDENT RNA VIRAL POLYMERASE  
The present invention provides nucleoside derivatives (principally uracil, cytosine and uridine derivatives) which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are...
DE60216798T2 ACYCLIC LINKER CONTAINING OLIGONUCLEOTIDES AND USES THEREOF  
Oligonucleotides having an internal acyclic linker residue, and the preparation and uses thereof, are described. Such uses include the preparation of acyclic linker-containing antisense...
DE10045123B4 The C. albicans TEC1 GEN (CaTEC1) and the encoded protein Tec1p  
The present invention relates to nucleotide sequences which code for proteins modulating the virulence of pathogenic fungal strains; vectors which contain these sequences; host cells which have...
DE10006590B4 Using Functionalized membranes or matrices for purifying nucleic acids and corresponding methods  
Application of a functionalized porous membrane to purify nucleic acids, the binding properties of the membrane with respect to nucleic acids being adjustable by controlling the conditions of an...