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DE69736950T2 TRICYCLIC piperdinyl DERIVATIVES SUITABLE AS farnesyl PROTEIN TRANSFERASE INHIBITORS  
Novel tricyclic compounds of formula (1.0) or a pharmaceutically acceptable salt or solvate thereof, wherein: one of a, b, c, and d represents N or NR<9>, wherein R<9> is O-, -CH3 or -(CH2)nCO2H...
DE69736699T2 A method for producing L-lysine  
A recombinant DNA autonomously replicable in cells of coryneform bacteria, comprising a DNA sequence coding for an aspartokinase in which feedback inhibition by L-lysine and L-threonine is...
DE60313855T2 GROWTH-REGULATING GENE  
The application discloses a new family of proteins, namely the epsin like proteins (ELP). Said proteins comprise an ENTH domain (Epsin NH2 Terminal Homology domain) and have growth inhibiting...
DE60216440T2 Immobilization of Oligonucleotides ON SOLID SUPPORT  
A solid support bound polynucleotide, preferably a 3'-O- or 5'-O-substituted polynucleotide, is disclosed. The polynucleotides are of formula: wherein Q is a substantially pure polynucleotide,...
DE60216416T2 METHOD FOR DETECTION OF chloral hydrate in dichloroacetic  
Methods for detecting chloral hydrate in dichloroacetic acid are described.
DE60214412T2 Simplified SARCODICTYN DERIVATIVES AS ANTI-TUMOR AGENTS  
There are provided sarcodictyin derivatives or pharmaceutically acceptable salts thereof, which are characterized by a simplified chemical structure and have anti-tumor activity. A process for...
DE69933738T2 Composition containing trehalose and amino acids  
An amino acid-sugar composition comprising an amino acid composition which comprises proline, alanine, glycine, valine, threonine, leucine, histidine, lysine, isoleucine, arginine, phenylalanine,...
DE602004003389T2 METHOD FOR PRODUCING 4'-AZIDONUKLEOSIDDERIVATEN  
A process for the preparation of a 4'-azido-2',3',5'-triacyl-nucleoside compound (I; B=B1; R<1 >is R<1a>CO- and R<2 >is R<2a>CO-) or a 4'-azidonucleoside compounds (I; B is B1 or B2 and R<1 >and...
DE60123277T2 macrolide antibiotics  
11,12 gamma lactone ketolides of the following formula: and pharmaceutically acceptable salts and solvates thereof, wherein R, R1, R2, and R3 are as described herein. The disclosure also relates...
DE60031957T2 COMBINATORIAL COMPLEX CARBOHYDRATE LIBRARIES AND METHOD FOR PRODUCING AND USE THEREOF  
The present invention concerns a carbohydrate library comprising a plurality of carbohydrate structures each being attached at a specific and addressable location of an array, whereas a...
DE202007003784U1 Apparatus for the purification of biomolecules  
device for the purification of biomolecules having by adsorptive separation in a a flat adsorbent (6) Chromatography module (2), the housing (3) at least one inlet (4) and at least one outlet (5)...
DE102006011077A1 A method for degradation of cellulose with nucleophiles  
The This invention describes a method for degradation of cellulose, by dissolving cellulose in an ionic liquid and with a nucleophile treated.
DE102006011076A1 Degradation of poly-, oligo- or di-saccharide or derivative e.g. partial degradation of cellulose for fiber or film production or complete degradation to glucose involves heating solution in ionic liquid e.g. quaternary ammonium compound  
Process for degradation of poly-, oligo- or di-saccharides or their derivatives comprises dissolving the material in ionic liquid(s) and treated at elevated temperature, optionally with addition...
DE102006011075A1 Process for the degradation of cellulose in solution  
The This invention describes a method for degradation of cellulose, by dissolving the cellulose in an ionic liquid and with an acid, optionally the addition of water, treated.
DE102004028241B4 New fluoroglycoside derivatives of pyrazoles, pharmaceutical compositions containing them and the preparation of these drugs  
The invention relates to substituted fluoroglycoside derivatives of pyrazoles of formula (I) as further defined in the specification, to the physiologically compatible salts thereof, to a method...
DE69736667T2 METHODS FOR THE DETECTION AND AMPLIFICATION nucleic acid sequences CONSUMPTION OF MODIFIED Oligonucleotides WITH INCREASED GOAL MELTING TEMPERATURE (TM)  
The present invention concerns oligonucleotides containing one or more modified nucleotides which increase the binding affinity of the oligonucleotides to target nucleic acids having a...
DE69434875T2 BMP-11 compositions  
Purified BMP-11 proteins and processes for producing them are disclosed. Recombinant DNA molecules encoding the BMP-11 proteins arc also disclosed. The proteins may be useful in regulating...
DE60214778T2 METHOD FOR ISOLATION OF eupalitin (3-O-BETA-D-GALACTOPYRANOSIDE) OFF Boerhavia diffusa  
The present invention relates to a process of isolation of bioactive eupalitin (3-O-O-D-galactopyranoside) of formula 1 possessing anti-osteoporosis activity by extraction of powdered leaves of...
DE60214725T2 METHOD FOR DETERMINING THE EXPRESSION OF DIHYDROPYRIMIDINDEHYDROGENASEGENS  
The present invention relates to prognostic methods which are useful in medicine, particularly cancer chemotherapy. The object of the invention to provide a method for assessing Dihydropyrimidine...
DE602004002692T2 Process for the preparation of Topiramate  
The present invention relates to a process for the preparation of topiramate, intermediates in this process and a process for the preparation of these intermediates.
DE602004002366T2 Lipid A and lipid A containing topical, particularly cosmetic, composition  
Lipid A compounds (I) are new. Lipid A compounds of formula (I) are new: [Image] AG 13-hydroxydecanoyl; AG 23-dodecanoyloxydecanoyl; R : H or PO(OR') 2; R' : H, M, 1-6C (un)saturated alkyl, phenyl...
DE60128296T2 Saccharide-alkyleneoxy and ink  
A saccharide-alkyleneoxy derivative comprising a compound represented by the following formula (1): A-(EP)n-OH wherein A represents a skeleton of a saccharide selected from the group consisting of...
DE10262018B4 Compositions, foodstuffs, foods, and beverages, confectionery, pet food, dietary special diet, child nutrition, sweeteners and pharmaceutical compositions containing condensed Palatinose  
The Invention relates to compositions, food, food and beverages, Confectionery, Animal feed, dietary Special diet, Child nutrition, sweeteners and to pharmaceutical compositions containing a new...
DE69233331T3 Combinatorial Strategies for Polymer Synthesis  
A method of forming an array of polymers on a solid support, comprising:(a) moving a dispenser containing a solution of a polymer toward a surface of a solid support until a tip of the dispenser...
DE60124170T2 Use of ascorbic acid derivatives to improve the synthesis of the epidermal ceramides  
Use of ascorbic acid derivative of formula (I) as stimulant of epidermic lipogenesis. Use of at least one ascorbic acid derivative of formula (I) for improving synthesis of epidermic ceramides. R1...
DE60122777T2 RECOVERING xylose  
The invention relates to a process of producing a xylose solution from a biomass hydrolysate by subjecting the biomass hydrolysate to nanofiltration and recovering as the nanofiltration permeate a...
DE60122345T2 PKSs WITH MODIFIED SPECIFICITY, THEIR PRODUCTION AND USE  
Biosyntheses of compounds whereof at least portions are polyketides produced by means of polyketide synthase (PKS) enzyme complexes are carried out after specific alterations have been made within...
DE60030286T2 CONTROL OF GENE EXPRESSION IN CELLS EUCARYOTIC  
DNA constructs and other compositions and methods for controlling gene expression in eukaryotic cells and organisms are derived from bacterial quorum sensing systems. One or more cis elements from...
DE4411176B4 Developer for PS plates and supplemental fluids for developer  
developer for presensitized photosensitive plates for making lithographic printing plates, containing an alkali metal silicate having a molar ratio SiO2/ M2O (wherein M represents an alkali metal...
DE102006008701A1 Procedure for transferring biomolecules into a cell, comprises preparing a complex from biomolecule and polymer, and transferring the biomolecule into a cell by contacting the cell with the complex  
Procedure for transferring biomolecule into a cell, comprises preparing a complex from the biomolecule, preferably nucleic acid, and a polymer, which is obtained through reacting an amine-monomer...
DE69133552T2 Non-A, non-B hepatitis virus antigen, and diagnostic procedures.  
Sequence (I) comprises (a) the Hutch c59 DNA sequence shown in SEQ ID NO:46 of the spec; (b) degenerate sequences of the sequence of (a); (c) a mutant variant of the NANBV Hutch c59 strain with...
DE60215157T2 USES OF ANTIVIRAL NUCLEOSIDE DERIVATIVES FOR THE PREPARATION OF A MEDICAMENT FOR THE TREATMENT OF HEPATITIS C INFECTION  
The present invention comprises nucleoside derivatives for use in the treatment or prophylaxis of hepatitis C virus infections. In particular, the present invention discloses the novel use of...
DE60213407T2 COMPOSITIONS FOR INHIBITING ANGIOGENESIS  
Methods for inhibiting angiogenisis are disclosed the comprise administering oleouropein and/or the products of its hydrolysis in therapeutically effective amounts. The methods and compositions of...
DE60122156T2 NEW disaccharides ANTI-arthritic EFFECT  
This invention refers to new disaccharides of formula (I), where R<1> is selected from the group consisting of hydrogen, linear or branched (C1-C4)-alkyl, phenylalkyl of less than ten carbon atoms...
DE60031793T2 Doxorubicin and daunorubicin-CONTAINING AGENTS AND THEIR THERAPEUTIC APPLICATIONS cytotoxic  
A cytotoxic agent comprising one or more modified doxorubicins/daunorubicin linked to a cell binding agent. A therapeutic composition for killing selected cell populations comprising: (A) a...
DE69935782T2 BREAST CANCER RESISTANCE PROTEIN (BCRP) AND FOR THIS CODING DNA  
The Breast Cancer Resistance Protein is described, as well as the cDNA encoding said protein. This protein has been found to confer resistance to cancer chemotherapeutic drugs.
DE69133556T2 Methods and compositions for the synthesis of BCH-189 and related compounds  
The present invention relates to a method of preparing BCH-189 and various analogues of BCH-189 from inexpensive precursors with the option of introducing functionality as needed. This synthetic...
DE60307749T2 Use of flavonoid derivatives for the treatment of atopic eczema  
The invention relates to the use of certain flavonoid derivatives for the preparation of formulations which are suitable for the prophylaxis and/or therapy of eczema. The formulations are...
DE60307503T2 Antiviral nucleoside  
The present invention relates to nucleoside derivatives for the treatment of Hepatitis C viral infections including compounds of formula I, pharmaceutical compositions comprising these compounds...
DE602004002696T2 NEW 14- AND 15-PRONGED RING COMPOUNDS  
The present invention relates to 14- or 15-membered macrolides substituted at the 4'' position of formula (I) and pharmaceutically acceptable derivatives thereof, to processes for their...
DE19720839B4 Modular technology for the production of long, exact DNA constructs in vitro, in particular for the preparation of constructs for the production of artificial chromosomes (MAC, mammalian artificial chromosome) of two stable cloned DNA components and the prototype vector ditelomerische PTAT  
The invention relates to a method for producing a DNA construct, whereby two or several DNAs are recombined in melted agarose. The invention also relates to vectors which can be used therefor, in...
DE69835308T2 Prodrugs and conjugates of Selenoenthaltenden compounds and their use  
Disclosed are prodrugs as follows:(I) a prodrug of the formulawhere A is a sulfur or a selenium, and R is a mono- di- or oligo-saccharide;(II) a prodrug of the formulawhere A is sulfur or...
DE69736840T2 Synthesis of nucleosides and polynucleotides  
Novel nucleosides, process for chemical synthesis of nucleosides and incorporation of the nucleosides into polynucleotides are disclosed. Also described are polynucleotides, such as antisense, TFO...
DE69736331T2 IMMUNE STIMULATING NUKLEINSAEUREMOLEKUELE  
An isolated immunostimulatory oligonucleotide comprising two or more unmethylated CpG dinucleotides, and having a sequence including the following formula: €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ5'N 1 X 1 X 2 CGTTN 2 3'...
DE69535260T2 Using a non-neutralizing antibody specific for the beta-subunit of luteinizing hormone for enhancing fertility  
The present invention relates to methods for enhancing fertility by reducing the activities and/or levels of circulating glycoprotein hormones having lutropin (LH) activity. The molecules of the...
DE60121615T2 PROCESS FOR PRODUCING OPTICALLY ACTIVE anthracyclines  
It is described a process for the synthesis of optically active anthracyclines by the fact that the key intermediate (R)2-acetyl-2-hydroxy-1,2,3,4-tetrahydronaphtalene...
DE20122767U1 Massive parallel method for decoding DNA and RNA  
This invention provides methods for attaching a nucleic acid to a solid surface and for sequencing nucleic acid by detecting the identity of each nucleotide analogue after the nucleotide analogue...
DE102005033903B4 Perfluoroalkyl-containing complexes, processes for their preparation, and their use and pharmaceutical compositions containing them  
Perfluoroalkyl-containing metal complexes (I) are new. Perfluoroalkyl-containing metal complexes of formula K1>-L(Q-R)-N(A)-X-Rf (I), are new. R : mono- or oligosaccharide bound with one hydroxy...
DE10138935B4 Synthetic compounds from non-mucin or its conjugated with a carrier compounds, monoclonal antibodies produced using them, this comprehensive anti-tumor agent and immune stimulants means to human immunodeficiency virus  
The purposes of this invention are preparation of the non-mucin type synthetic compounds-carrier conjugated compounds which are stable against enzymes, and which have the ability of specific...
DE69636339T2 GROWTH INHIBITORS AGAINST leukemic CELLS OF ANTISENSE oligonucleotide derivatives AGAINST Wilms' tumor gene CONTAINS  
A leukemic cell growth inhibitor containing antisense oligonucleotide derivatives against Wilms' tumor gene (WT1).