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DE10259713A1 A method for expressing stabilization and improvement of specific effector function of single-chain antigen knower genetic constructs (scARC) and corresponding mutant MDM2 protein specific SCT-cell receptors  
The present invention relates to a process for preparing stabilized single chain antigen recognized genetic constructs (scARC), in which in addition to the conventional V1/2-Li-V2/1-C4/3-sc...
DE10259374A1 Carboxamide-substituted dyes for analytical applications  
The present invention relates to carboxamide-substituted dyes, their preparation and to the use of such dyes as labeling groups in the analysis.
DE10258924A1 coated with the adhesion of biological material mediating substances device  
The invention relates to devices with at least one with tissues and / or fluids of the human or animal body by coming into contact surface. These surfaces are at least partially coated with...
DE10258008A1 New heterocyclic Fluorglycosidderivate, pharmaceutical compositions containing them and their use  
The invention relates to substituted heterocyclic Fluorglycosidderivate of the formula I, wherein the radicals have the meanings indicated, and their physiologically acceptable salts and processes...
DE10361928A1 Analyzing the condition of the uterine mucosa, useful for assessing endometrial receptivity or diagnosing uterine tumor, based on measuring expression of specific beta subunits of chorionic gonadotrophin  
Method for determining defined conditions or alterations in the uterine mucosa, or in the epithelium of other organs, by: (i) isolating mRNA from a blood and/or tissue sample; and (ii) quantifying...
DE10261782A1 New nucleic acid encoding a staphylococcal serine protease, useful for treating bacterial infections or modifying biomolecules, also encoded enzymes and related antibodies  
Nucleic acid molecule (I) encoding a staphylococcal serine protease, is new. (I) is at least 82, best 90, % identical with either a 1623 bp sequence (SEQ ID. 1), defined in the specification, or...
DE10260592A1 New 2-(1-((hetero)aryl(oxy))-ethyl)-nitrobenzene derivatives, useful for introducing intramolecular triplet sensitized photolabile protecting groups into synthons for light-controlled biopolymer production  
2-(1-((Hetero)aryl or (hetero)aryloxy)-ethyl)-nitrobenzene derivatives (I) are new. Also new are nucleotide synthon compounds (II) containing a photolabile protecting group derived from (I)....
DE10260591A1 Stepwise synthesis of biopolymer, e.g. nucleic acid, using synthons having two-stage protecting group activated by cleavage of triplet-sensitized and/or labeled photoactivatable group to allow quality control  
Synthesis of biopolymers (A) by stepwise construction from protected synthons, where at least one of which has a two-stage protecting group (i.e. a group activated by irradiation and cleaved by...
DE10260085A1 Selective extraction of 2-keto-L-gulonic acid from polar solution, especially reaction mixture obtained in preparing ascorbic acid by lactonization, using mixture of tertiary amine and polar organic diluent  
2-Keto-L-gulonic acid (KGA) is extracted from a polar solvent, by contacting the solvent with an extractant (E1) comprising a tertiary amine (I) and a polar organic diluent (II) in a mixing...
DE10259844A1 New mannopyranoside-based peptidomimetic compounds, useful for treatment or diagnosis of e.g. intestinal, autoimmune or tumor diseases, are selective alpha4, beta7-integrin antagonists  
Mannopyranoside-based peptidomimetic compounds (I) are new. Mannopyranoside-based peptidomimetic compounds of formula (I) are new. X = O or CHR15; R1-R5, R15 = 1-30C organic group optionally...
DE10259403A1 A process for the production of alkyl and / or salts Alkenyloliglykosidcarbons√§ure  
Disclosed is a new process for the production of aqueous pastes of alkyl and / or alkenyl oligoglycoside carboxylic acid salts with a reduced content of organic chlorine compounds, which is...
DE10259245A1 Derivatives of Asimadolins with covalently bonded acids  
The present invention relates to derivatives of N-methyl-N - [(1S) -1-phenyl-2 - ((3S) -3-hydroxypyrrolidine-1-yl) -ethyl] -2,2- diphenylacetamide with covalently bound acids and the salts,...
DE10257523A1 Process for the preparation of carboxyl groups, alkyl or alkenyl polyglycosides  
The invention relates to methods for the preparation of acid group-containing alkyl polyglycosides, wherein a reaction mixture containing at least one alkyl polyglycoside, having a at least two...
DE10258258A1 Isolating nucleic acids from liquid samples, for isolating viral nucleic acid from donated blood, by retention on an inorganic oxide carrier, comprises treatment with protease to improve sensitivity and efficiency  
Isolating nucleic acid (NA) from liquid samples comprises: mixing the sample with binding buffer (BB) to give a mixture of pH below 7, treating with a carrier (A) so that NA binds to it,...
DE10254214A1 Oligoribonucleotides for treating degenerative skin symptoms by RNA interference  
Oligoribonucleotides which are able to induce the degradation of the mRNA of connective tissue degrading enzymes, and pharmaceutical and cosmetic compositions for topical application, containing...
DE10253514A1 Production of new or known monomeric uronic acid compounds, useful e.g. as immunosuppressive or antiarthritic agents, by hydrolyzing bacterially produced polyuronic acid  
Production of monomeric uronic acids (or their derivatives) (I) involves (a) fermenting a bacterial strain producing a polyuronic acid (II) formed from (I) units, (b) isolating (II) from the...
DE10253351A1 Isolation of nucleic acid by binding to solid phase, useful e.g. in forensic or diagnostic medicine, uses binding buffer containing monovalent and multivalent ions, eliminates need for alcohol in wash buffer  
Method for isolating nucleic acid (NA) from solution by binding it to a solid phase, comprises treating the NA-containing solution with additives, contacting with the solid phase and optionally...
DE60101056T2 Process for the preparation of ribavirin  
A process for the preparation of ribavirin on an industrial scale is described which comprises the reaction of glycosylation of 3-substituted triazoles in the presence of a Lewis acid. Said...
DE10251246A1 New antagonists of calcitonin gene-related peptide or amylin, useful for treating or preventing e.g. migraine or inflammation, are specific binding nucleic acids  
An antagonist (I) of CGRP (calcitonin gene-related peptide), especially a nucleic acid, preferably one that binds to CGRP, is new. Independent claims are also included for: (1) antagonist (Ia) of...
DE10262018A1 Condensed palatinose and processes for their preparation  
The invention relates to a novel palatinose condensation product obtained by condensation of the disaccharide palatinose in a melt of palatinose, water and an organic acid.
DE10249795A1 Nucleotide support, useful for assessing genetic risk of arteriosclerosis, comprises probes directed against nine risk-associated genes or their variants  
Nucleotide support (A) for determining the genetic risk of arteriosclerosis comprises oligonucleotide probes (I) for investigating nine specified genes (II) in a patient sample, and each (I) is at...
DE10249552A1 Water soluble iron carbohydrate complexes, their preparation and pharmaceutical compositions containing them  
Water-soluble iron-carbohydrate complex obtainable from an aqueous iron (III) salt solution and an aqueous solution of the product of the oxidation of one or more maltodextrins with an aqueous...
DE10249171A1 Polymerase chain reaction method for detecting Salmonella in an animal, environmental or food samples, based on specific amplification of part of the invA gene, also provides indication of virulence  
A PCR method for detecting Salmonella, is new. A PCR method for detecting Salmonella comprises: (a) incubating a sample first in peptone broth and then in Rappaport-Vassiliadis medium; (b)...
DE10248453A1 Chalcomycin derivatives  
The invention relates to novel chalcomycin derivatives, to pharmaceutical compositions containing them or their salts, and the use of the chalcomycin derivatives for the treatment of diseases,...
DE10135098B4 A process for the production of peracylated 1-O-glycosides  
A process for the production of peracylated 1-O-glycosides of general formula I in the sugar1 a functionalized in 1-OH position monosaccharide, R is methyl, ethyl, propyl, isopropyl, t-butyl,...
DE10328887A1 alkaline protease  
The invention relates to an alkaline protease having a prepro, the prepro represents a mutant sequence of the amino acid sequence of SEQ ID NO .: 1 or owned an amino acid sequence having a 80% or...
DE10247476A1 Concentration and isolation of oregonin from alder bark, useful as antioxidant in cosmetic or therapeutic compositions, includes treating hot water extract with adsorber resin  
Improved method for concentration and isolation of oregonin (I) from alder (Alnus) bark. Improved method for concentration and isolation of oregonin (I) from alder (Alnus) bark comprises...
DE10245779A1 Predicting responsiveness of a subject with breast cell proliferative disorder, useful for treating or differentiating breast cell proliferative disorders comprises analyzing methylation pattern of a genomic DNA from the subject  
Predicting the responsiveness of a subject with a cell proliferative disorder of the breast tissues to a therapy comprising analyzing the methylation pattern of a target nucleic acid by contacting...
DE19714255B4 A process for the production of alkyl and / or alkenyl oligoglycosides by acetalization of a direct glucose / fatty alcohol suspension in the presence of acid catalysts  
A process for the production of alkyl and / or alkenyl oligoglycosides by direct acetalization of a glucose / fatty alcohol suspension in the presence of acidic catalysts, wherein the total molar...
DE10247790A1 Solid phase synthesis of labelled oligonucleotide conjugate, by nucleophilic substitution of labile protecting group on terminal hydroxy group with labeling reagent  
A solid phase-supported method for the production of oligonucleotide conjugates (I) involves the reaction of 3'-5'- or 5'-3'-structured oligonucleotide (II), having the terminal hydroxy group...
DE10247073A1 Monomeric uronic acid compound production, for use e.g. as immunosuppressive, antirheumatic or cardiovascular agents, by hydrolyzing bacterially produced polyuronic acid  
Production of monomeric uronic acids (I) involves (a) fermenting a bacterial strain producing a polyuronic acid (II) formed from (I) units, (b) isolating (II) from the supernatant of the...
DE10246824A1 Analyzing nucleic acid mixture by hybridization to an array, useful e.g. for expression analysis, using sample mixture of labeled restriction fragments of uniform size  
Method for analyzing a nucleic acid (NA) mixture by hybridization to a DNA array of immobilized NA, which uses a labeled NA mixture of reduced complexity as the hybridization sample. Method for...
DE10244456A1 A method for the detection and differentiation of bacteria  
The present invention relates to the field of diagnosis of micro-organisms, in particular the detection of bacteria. The invention relates in particular hybridization methods and amplification...
DE10238434A1 A method for identifying herbicidally active substances  
The present invention relates to a method for identifying compounds with herbicidal activity. Furthermore, the invention nucleic acid constructs, vectors containing the nucleic acid constructs,...
DE10239585A1 New nucleic acid molecules, useful for detecting plant material, e.g. genetically modified material in food, are designed to amplify the chloroplast tRNA-Leu gene  
Nucleic acid molecules (A) comprising 4 defined sequences given in the specification (and below), which are designed to amplify the chloroplast tRNA-Leu gene or their complements or derivatives,...
DE10232776A1 New oligonucleotides for specific detection of microorganisms, useful e.g. for detecting or quantifying microbes on the skin, in foods, clinical samples or water, by in situ hybridization  
Oligonucleotides (ON) for specific detection of microorganisms, are (i) are any of 30 sequences reproduced; (ii) have at least 80, best 95, % correspondence with (i); (iii) are derived from (i) or...
DE3912046B4 A method for marking a component of an aqueous liquid and lumineszenzphotostabiles reaction product  
A method of labeling a component of an aqueous liquid, characterized in that (a) to which said component-containing liquid has a luminescence dye from the group of cyanine, merocyanine and styryl...
DE10262005A1 Foodstuff or pharmaceutical compositions containing hydrogenated condensed palatinose, useful e.g. as sweetener or soluble dietary fiber source and/or for combating intestinal inflammation or cancer  
Foodstuffs, sweeteners or pharmaceutical compositions containing hydrogenated condensed palatinose (I) are new. Foodstuffs, sweeteners or pharmaceutical compositions containing hydrogenated...
DE10242433A1 Chip carrying probes for specific genes, useful for rapid monitoring of organism status, particularly during fermentation  
Chip (A) that carries probes (I) for at least one of 34 specified genes, or from similarly regulated genes involved in the corresponding metabolic pathways in other organisms. Chip (A) that...
DE10242062A1 New hydrogenated condensed palatinose products, useful in food, feed or medicament compositions, e.g. for combating diabetes or cancer, obtained by catalytic hydrogenation of condensed palatinose solution  
Production of hydrogenated condensed palatinose (I) involves catalytic hydrogenation of a solution containing a condensed palatinose (II). Independent claims are included for: (1) (I) obtained by...
DE10241938A1 Selecting specific-bonding nucleic acid, by a modified SELEX process that includes purification by ultrafiltration to facilitate automation  
Selecting, from a mixture of candidates, at least one nucleic acid (NA) that is a ligand able to bind a target molecule (TM), is new. Selecting, from a mixture of candidates, at least one nucleic...
DE10111682B4 Caloporoside derivatives, processes for their preparation and their use  
Compounds of formula I in which: R1, R2, R3, Independently of one another H or acyl radicals having 1 to 10 carbon atoms; and R4 Is H or -C (O) (CH2)nCOOH, wherein n is 1 to 7; except that R1, R2,...
DE10244057A1 Use of nucleic acid for detecting explosives, by specific binding interaction, also new aptamers for the process and test device  
Use of a nucleic acid (I) for detecting an explosive (II). (I) binds specifically to at least part of the molecular structure of (II) and this binding is detected. Independent claims are also...
DE10241152A1 Tubulysin biosynthesis genes  
ssDNA molecule selected from the group consisting of: (i) an ssDNA molecule according to a sequence1; (Ii) an ssDNA molecule with a ss-DNA-molecule according to (i) with respect to its nucleotide...
DE10241116A1 Process for the recovery of uridine from molasses  
The present invention relates to a process for the recovery of uridine from molasses by chromatographic method, said enriched uridine and obtained in high yield and high purity, and in particular...
DE10255104A1 Methods and nucleic acids for the analysis of breast cell proliferative disorders  
The present invention relates to modified and genomic sequences, oligonucleotides and / or PNA-oligomers for detecting the cytosine methylation state of genomic DNA, and a method for ascertaining...
DE10240417A1 Decoy oligonucleotide inhibition of CD40 expression  
The present invention relates to decoy oligonucleotides with the nucleic acid sequence according to SEQ ID NO: 1 to 36 and their use as medicaments.
DE10237704A1 Method and apparatus for intermolecular transfer of activation energy for bond cleavage through space  
The present invention relates to a method for the cleavage of chemical bonds, whereby the activation energy is supplied to the bond cleavage through the space from a carrier molecule that can move...
DE10237393A1 Determining risk of developing arteriosclerosis or coronary artery disease, by detecting both polymorphisms in the mbl2 gene and infection by Chlamydia pneumoniae  
Method for determining an indicator of the risk of developing arteriosclerosis and severe heart disease of the coronary artery type by detecting both: (a) polymorphisms in the human mbl2 gene; and...
DE10240923A1 Flavonoid derivatives for eczema treatment  
It is the use of certain flavonoid derivatives for the preparation of formulations described suitable for the prophylaxis and / or therapy of eczema. In particular, the preparations are suitable...