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DE60126416T2 TREATING ARTHRITIS AND RELATED COMPOSITIONS  
A 2-glucosamine derivative of the general formula (I):wherein R is an alkyl radical of the general formula CnH2n+1 and n is selected from 2-12; and pharmaceutically acceptable salts, esters and...
DE60126319T2 Immobilization of aminated BIOPOLYMERS ON SUBSTRATES BY DIRECT ADSORPTION  
An assay article for detection biopolymers contained in a sample is described. The assay article includes a substrate and a biopolymer directly adsorbed on the surface of the substrate. A...
DE60125212T2 Use of Aivlosin for the treatment and prevention of Lawsonia infections in pigs.  
The use of AIVLOSIN, as such or as a pharmaceutically acceptable (non-toxic) derivative such as an acid addition salt, for the preparation of a veterinary medicament for the treatment and...
DE60032235T2 Ribonukleinsäurederivate  
Provided is a preparative method for isolating RNA comprising an oligo-or polynucleotide from a sample, which method comprises: (a) treating the sample with a reactant capable of covalently...
DE69935248T2 DNA PROTEIN MERGERS AND APPLICATIONS OF THE SAME  
Disclosed herein are molecules that include a deoxyribonucleic acid (DNA) covalently bonded to a protein and uses thereof.
DE69737432T2 Farnesyl diphosphate synthase  
A mutant prenyl diphosphate synthase capable of synthesizing prenyl diphosphates, shorter than those synthesized by the original enzyme, by modifying the amino acid sequence in and upstream of the...
DE69535376T2 EXPRESSION VECTOR ABACAVIR  
The present invention is directed to alphavirus expression vectors comprising at least part of an alphavirus genome and heterologous RNA inserted downstream of an alphavirus base sequence having...
DE60126762T2 Combinatorial production of nucleotide and nucleoside (XITP) analogs  
Hydrazide-substituted nucleoside or nucleotide analogs (I) are new. Nucleoside or nucleotide analogs of formula (I) are new. [Image] R 1H; mono-, di- or tri-phosphate group; or protective group...
DE60033851T2 Biomolecules MULTIPLE CONNECTION SECTIONS FOR BINDING TO A SUBSTRATE SURFACE  
Biomolecules are provided having multiple binding sites for attachment to a substrate surface. The multiple attachment sites may be produced directly on the biomolecule or through use of branched...
DE60033648T2 mounted on a surface polyfunctional polymer networks for sensor chips  
The invention relates to polyfunctional polymer networks comprising an assembly of cross-linked polymer subchains attached to a surface, with each polymer subchain comprising a multitude of...
DE102006020885A1 Inserting a tag sequence into a nucleic acid comprises using an anchor oligonucleotide comprising a hybridizing anchor sequence and a nonhybridizing tag-template sequence  
Inserting a tag sequence into a nucleic acid comprises hybridizing an anchor sequence of an anchor oligonucleotide to a sequence segment of a template nucleic acid and synthesizing a new nucleic...
DE69935250T2 OLEANDOMYCIN DERIVATIVES  
The invention relates to novel compounds from the class of the macrolide antibiotic oleandomycin of the general formula (I)whereinR1 has the individual meaning of -CH2CH3 group, of a fragment of...
DE69736067T9 NEW cryptophycin derivatives as antineoplastic agents  
The invention provides novel cryptophycin compounds which can be useful for disrupting the microtubulin system, as anti-neoplastic agents, and for the treatment of cancer. The invention further...
DE69636936T2 FACTOR-1, inducible by hypoxemia, AND METHOD FOR APPLICATION  
The purified and characterization of hypoxia-inducible factor 1 (HIF-1) is described. HIF-1 is composed of subunits HIF-1± and HIF-1². Purified HIF-1± polypeptide, its amino acid sequence and...
DE60128395T2 NUTRITIONAL COMPOSITION WITH HEALTH PROMOTING EFFECT CONTAINING OLIGOSACCHARIDES  
A nutritional composition having beneficial effect in the gastrointestinal tract, especially an anti-adhesion effect on pathogenic micro-organisms and a bifidogenic effect, contains non-digestible...
DE102006019480A1 Use of gene expression profiles to detect any postoperative tissue incompatibility reactions after liver transplantation  
Gene expression profiles obtained from a patient sample in vitro are used to detect any postoperative tissue incompatibility reactions after liver transplantation. An independent claim is also...
DE10014639B4 cDNSen with a coding of enzymes for fructan synthesis with a low-temperature expression as well as methods for their isolation  
process to isolate a cDNA that encodes an enzyme for fructan synthesis, which is active at a temperature of about 4 ° C, characterized by the following steps: - Cold-conditioning a winter wheat...
DE69434839T2 Transferrin receptor GENES FROM HAEMOPHILUS  
Purified and isolated nucleic acid is provided which encodes a transferrin receptor protein of a strain of Haemophilus or a fragment or an analog of the transferrin receptor protein. The nucleic...
DE69334071T2 PROSTATE SPECIFIC MEMBRANE ANTIGEN  
This invention provides for an isolated mammalian nucleic acid molecule encoding a mammalian prostate-specific membrane antigen. This invention provides for nucleic acid probes which specifically...
DE69233669T2 BACTERIAL nitroreductase FOR REDUCING CB1954 AND ANALOG THEREOF cytotoxic FORM  
The invention provides a nitroreductase, obtainable from a bacterium having the following characteristics as exemplified by examples isolated from Escherichia coli B and Bacillus...
DE602004003907T2 Avermectin and AVERMECTINMONOSACCHARIDDERIVATE IN THE 4 '' - or 4 position SUBSTITUTED ARE AND PESTICIDES PROPERTIES HAVING  
What is described are a compound of the formula (I) Wherein U is —N(R2)OR3 or —N+(O−)═C(RE)RZ); n is 0 or 1; X—Y is —CH═CH— or —CH2—CH2—; R1 is C1-C12alkyl, C3-C8cycloalkyl or C2-C12alkenyl; R2...
DE60125154T2 TEILDESULFATIERTE GLYKOSAMINOGLYKANDERIVATE WITH anti-angiogenic ACTIVITY AND WITHOUT anticoagulant EFFECT  
Partially desulfated glycosaminoglycan derivatives are described, particularly heparin, and more particularly formula (I) compounds where the U, R and R1 groups have the meanings indicated in the...
DE102007018551A1 Preparing gemcitabine comprises reducing a dihydro-furan-2-one compound to give a furan compound, activating the hydroxyl group and reacting with a protected cytosine to give a protected nucleoside and terminal protection of the nucleoside  
Preparation of gemcitabine comprises reducing a dihydro-furan-2-one compound (16A) to give a furan compound (19), activating the hydroxyl group by converting into a sulfonate (mesylate), reacting...
DE102006017492A1 Drug fixation on polymer surfaces  
Of the The present invention relates to compounds according to the general Formula 1, where R1. R2, R3, R4, R5, R6. R7, R8th, R9 and R10 independently selected are selected from the group...
DE69636734T2 Nucleosides WITH ANTI-HEPATITIS B VIRUS EFFECTIVENESS  
A method for the treatment of a host, and in particular, a human, infected with HB V is provided that includes administering an HBV-treatment amount of the stabilized nucleotide of a nucleoside...
DE69636720T2 THE fibroblast growth factor homologous FACTOR-1 (FHF-1) AND METHODS FOR ITS USE  
A novel protein, fibroblast growth factor homologous factor-1 (FHF-1), the polynucleotide sequence encoding FHF-1, and the deduced amino acid sequence are disclosed. Also disclosed are diagnostic...
DE69434890T2 CLONING AND RECOMBINANT PRODUCTION OF vespid venom HYALURONIDASE AND ON THE BASIS OF IMMUNOLOGICAL THERAPIES  
The present invention is directed to nucleic acids encoding vespid venom enzymes, or fragments thereof, recombinant vectors comprising such nucleic acids, and host cells containing the recombinant...
DE69334102T2 Arrangement for regulating the cytokine  
Substances comprising a N-sulfated or N-acetylated or non-sulfated N-acetylated 4-deoxy-4-en-iduronoglucosamine in substantially purified form, including compositions containing same and their...
DE60217465T2 Nucleoside AS INHIBITORS OF RNA-DEPENDENT RNA VIRAL POLYMERASE  
The present invention provides nucleoside derivatives (principally uracil, cytosine and uridine derivatives) which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are...
DE60216798T2 ACYCLIC LINKER CONTAINING OLIGONUCLEOTIDES AND USES THEREOF  
Oligonucleotides having an internal acyclic linker residue, and the preparation and uses thereof, are described. Such uses include the preparation of acyclic linker-containing antisense...
DE10045123B4 The C. albicans TEC1 GEN (CaTEC1) and the encoded protein Tec1p  
Nucleic acid molecule which for cloning a gene encoding a transcription factor is suitable and / or a protein having the biological activity of a transcription factor coded and as a means for...
DE10006590B4 Using Functionalized membranes or matrices for purifying nucleic acids and corresponding methods  
use a functionalized porous Membrane for purifying nucleic acids, the binding properties for nucleic acids over the Conditions in a surrounding medium can be adjusted, characterized in that the...
DE69636752T2 HUMAN GROWTH FACTOR 2 SPECIFIC FOR VASCULAR ENDOTHELIAL  
Disclosed is a human VEGF2 polypeptide and DNA(RNA) encoding such VEGF2 polypeptides. Also provided is a procedure for producing such polypeptide by recombinant techniques and antibodies and...
DE60310944T2 NEW FORMS of interfering RNA MOLECULES  
The present invention is related to a ribonucleic acid comprising a double stranded structure whereby the double- stranded structure comprises a first strand and a second strand, whereby the first...
DE60309779T2 A process for producing cellulose acetate  
A process for manufacturing xyloligosaccharides comprises: steaming a corncob meal under conditions of a temperature of 150 to 250 DEG C and a pressure of 20 to 29 Mpa; filtering the steamed...
DE602004003948T2 PRODUCING 2-18F-2-deoxy-D-GLUCOSE BY SOLID PHASE SYNTHESIS  
The invention relates to a compound of formula (I): wherein P1, P2, P3, and P4 are each independently hydrogen or a protecting group; and n is an integer of from 2 to 20 and to the use of such...
DE602004003809T2 NEW 14- AND 15-PRONGED RING COMPOUNDS  
The present invention relates to 14- or 15-membered macrolides substituted at the 4'' position of formula (I) and pharmaceutically acceptable derivatives thereof, to processes for their...
DE602004003755T2 Thermostable Taq Polymerase fragment  
It was found that a fragment of native Thermus aquaticus DNA polymerase (TaqWT) lacking 288 N-terminal amino acids (Taq DELTA 288) possesses an increased thermostability over TaqWT, Taq DELTA 279,...
DE60124411T2 IONIC LIQUIDS AND THEIR USE AS SOLVENTS  
Ionic compounds with a freezing point of up to 100° C. are formed by the reaction of an one amine salt of formula (I) R1R2R3R4N+X-, such as choline chloride with an organic compound (II) capable...
DE60032470T2 CURE THE SULFOPYRANOSYLACYLGLYCEROLDERIVATE CONTAIN  
A medicament containing at least one compound selected from the group consisting of compounds represented by General formula (1): wherein R101 represents an acyl residue of an unsaturated higher...
DE19811540B4 Apicularen A, processes for its preparation and cytostatic agent with apicularen A  
apicularen A of formula
DE69934227T2 On beta-arabinose and its analogues based antisense oligonucleotides  
The present invention relates to modified oligonucleotide therapeutic agents to selectively prevent gene transcription and expression in a sequence-specific manner. In particular, this invention...
DE69836697T2 New 3.6-hemi-9a-Azalidklasse  
Novel macrolide antibiotics (I) comprise 3,6-hemiketals of 9a-azalides. Macrolides of formula (I) and their addition salts with inorganic or organic acids are new. [Image] R1OH or L-cladinosyl of...
DE60124594T2 macrolide antibiotics  
The present invention relates to 11,12 gamma lactone ketolides of formula (I) wherein R, R1, R2, R3 are as defined herein and pharmaceutically acceptable salts and solvates thereof, to process for...
DE60122791T2 A process for preparing clarithromycin with non-pharmaceutical grade  
High purity clarithromycin of Form II crystals can be easily prepared in a high yield by a process comprising the steps of: protecting the 9-oxime hydroxy group of erythromycin A 9-oxime or a salt...
DE10228785B4 Detection of toxic algae  
oligonucleotide characterized in that one of the sequences SEQ ID No.1 to 19 exhibits.
DE69836428T2 carcinostatic SUBSTANCES  
Agents capable of inhibiting the proliferation of cancer cells and cancers in the tissues therearound or unaffected tissues. Specifically, carcinostatic agents containing as the active ingredient...
DE69836395T2 Primers for the detection of HIV-1  
The present invention provides improved primers for the polymerase chain reaction (PCR) amplification of a nucleic acid sequence from the gag gene of the human immunodeficiency virus type 1...
DE60035107T2 SPLICE VARIANTS OF LIM MINERALIZATION PROTEIN  
The present invention is directed to isolated nucleic acid molecules that encode LIM mineralization protein, or LMP. The invention further provides vectors comprising nucleotide sequences that...
DE69933186T2 Method for purifying and manipulating nucleic acid using paramagnetic particles  
The present invention relates to a composition which is useful for the reversible binding of a nucleic acid molecule. The composition, which may be packaged in a kit, includes a paramagnetic...