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9034826 |
Use of epidermal growth factor for the morphofunctional restoration of peripheral nerves in diabetic neuropathy
The present invention is relevant to human medicine, and, in particular, to the use of Epidermal Growth Factor (EGF) in a pharmaceutical composition, said composition is administered through... |
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9006180 |
Methods for treating tourniquet-induced injuries
The present invention relates to treating a tissue in a mammal from the effects of reperfusion using flagellin. |
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8969532 |
Methods for the purification of polypeptide conjugates comprising polyalkylene oxide using hydrophobic interaction chromatography
The present invention provides processes for the manufacturing of polypeptide conjugates. In particular, the invention provides methods for the purification of polypeptide conjugates, which... |
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8952127 |
Peptoids useful for catalyzing the mineralization of calcium carbonate
The present invention provides for a bio-mimetic polymer capable of catalyzing CO2 into a carbonate. |
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8945558 |
Methods for treating myocardial infarction comprising administering an IL-6 inhibitor
The present inventors investigated the effects of anti-IL-6 receptor antibodies on improving the condition of infarcted areas in myocardial infarction, and on suppressing left ventricular... |
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8945940 |
Mass- and property-tuned variable mass labeling reagents and analytical methods for simultaneous peptide sequencing and multiplexed protein quantification using thereof
The present invention provides variable mass labeling reagents, a set of the variable mass labeling reagents, and a multiplexed set of variable mass labeling reagents. |
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8906866 |
Antibiotic compositions for the treatment of gram negative infections
Provided herein are novel compounds and novel protected compounds that can be derived from polymyxin, including, e.g., polymyxin A. The novel compounds have antibacterial properties against a... |
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8841250 |
Method for promoting muscle repair comprising administering G-CSF at the site of injury
The present invention relates to muscle repair promoters for local application that contain a colony-stimulating factor (CSF) as an active ingredient. The muscle repair promoters of the present... |
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8772450 |
Beta-amino acids
Disclosed are β-amino acid monomers containing cylcoalkyl, cycloalkenyl, and heterocylic substituents which encompass the α and β carbons of the peptide backbone and β-polypeptides made from such... |
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8765678 |
Inhibition of the renin-angiotensin system for the treatment of renal, vascular and cartilage pathology
A method of treating a disease or condition in which up-regulating GAGs is therapeutically beneficial is disclosed, in particular osteoarthritis and skin diseases. The method comprises locally... |
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8759317 |
Method of treatment of cancer using guanosine 3′, 5′ cyclic monophosphate (cyclic GMP)
A method of treating cancer through use of guanosine 3′,5′-cyclic monophosphate (cyclic GMP). Cyclic GMP decreases the number of human breast cancer and prostate adenocarcinoma as well as... |
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8729020 |
Methods for the treatment of aortic fibrosis with VIP fragments
The invention relates to compositions comprising vasoactive intestinal peptide (VIP) or fragments thereof, and the use of such compositions in the treatment of aortic fibrosis and other associated... |
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8729027 |
Therapeutic agent for fibromyalgia containing etanercept
Disclosed is a drug effective in the treatment of fibromyalgia. Basically, the disclosed therapeutic agent was created on the basis of experiments showing improvement in symptoms when etanercept... |
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8722618 |
IL4/IL13 binding repeat proteins and uses
IL4/IL13-binding proteins comprise binding domains, which inhibit IL4/IL13 binding to IL4Ralpaha and common gamma chain complexes (Type 1) and inhibit IL4 binding to IL4Ralpha and IL13Ralpha1... |
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8722626 |
Method for controlling fibrosis and other pathological deposits in tissues comprising administering a GHRP-6 composition
The present invention is related to the use of secretagogue peptides repeatedly administered as part of a pharmaceutical composition that prevent and eradicate the deposition of pathological... |
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8673842 |
Polypeptoid pulmonary surfactants
The present invention provides spreading agents based on sequence-specific oligomers comprising a peptoid, a peptide-peptoid chimera, a retropeptoid or a retro(peptoid-peptide) chimera, and... |
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8658600 |
Antineoplastic hydrogels, and enzyme-instructed preparations thereof
Disclosed is a general methodology to create nano fibers of therapeutic molecules that have a dual role, as both the delivery vehicle and the drug itself. It is shown that with proper molecular... |
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8653332 |
Extracellular plant ferredoxin-like protein and uses thereof
Disclosed are polypeptides, nucleic acids, and related compositions that render plants resistant to bacterial pathogens. Also disclosed are transgenic plants having the nucleic acids and resistant... |
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8642552 |
Use of epidermal growth factor for the morphofunctional restoration of peripheral nerves in diabetic neuropathy
The invention relates to human medicine and to the use of epidermal growth factor (EGF) for preparing a pharmaceutical composition which is administered by infiltration into the periphery of nerve... |
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8637636 |
Peptide synthesis apparatuses
Methods, apparatus, systems, computer programs and computing devices related to biologically assembling and/or synthesizing peptides and/or proteins are disclosed. |
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8624085 |
Insect resistant protein and insect-resistance gene encoding the insect-resistant protein
An insect-resistant protein exhibiting a sufficient resistance to insects; an insect-resistance gene encoding the insect-resistant protein; a recombinant vector containing the insect-resistance... |
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8618059 |
Methods for treating reperfusion injuries using flagellin
The present invention relates to treating a tissue in a mammal from the effects of reperfusion using flagellin. |
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8617624 |
Compositions, systems and methods for the diagnosis, prevention and treatment of disorders associated with azetidine-2-carboxylic acid
Methods and systems for detecting azetidine-2-carboxylic acid (Aze) in food consumable by humans and animals are provided. Also provided are methods and systems for inactivating Aze in food and... |
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8614184 |
HCG formulations for achieving weight loss
A formulation of human chorionic gonadotropin (HCG) for promoting weight loss comprising reconstituted HCG in an amount sufficient to promote weight loss; at least one vitamin selected from the... |
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8598120 |
Methods for treatment using amylin family peptides
The present invention relates to novel compounds having a function of a peptide in the amylin family, related nucleic acids, expression constructs, host cells, and processes production of the... |
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8586526 |
DNA-binding proteins and uses thereof
Disclosed herein are polypeptides, polynucleotides encoding, cells and organisms comprising novel DNA-binding domains, including TALE DNA-binding domains. Also disclosed are methods of using these... |
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8586330 |
Methods for producing secreted polypeptides having biological activity
The present invention relates to methods for producing a polypeptide having biological activity, comprising: (a) cultivating a fungal host cell in a medium conducive for the production of the... |
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8569235 |
Treatment of kidney disorders with VIP fragments
The invention relates to compositions comprising vasoactive intestinal peptide (VIP) or fragments thereof, and the use of such compositions in the treatment of kidney disease, in particular kidney... |
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8569229 |
Compositions and methods which modulate G-protein signaling for the treatment of inflammatory disorders such as asthma and allergic conjunctivitis
Compositions and methods for the treatment of asthma and inflammatory ocular disorders are disclosed. |
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8541670 |
Compositions and methods for inhibiting tumor cell growth
The present invention relates to compositions and methods for inhibiting the activity of an enzyme, for example, Protein Kinase B, p70S6K and/or Abl using the catalytic subunit of Protein Kinase A... |
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8541221 |
Primate T-lymphotropic viruses
Disclosed are compositions and methods related to the isolation and identification of the primate T-lymphotropic viruses, HTLV-3 and HTLV-4. The diversity of HTLVs was investigated among central... |
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8536231 |
Methods for treating diabetic foot ulcers
The present invention provides methods and pharmaceutical formulations for treating diabetic foot ulcers. |
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8530191 |
Method for preventing formation of trisulfide derivatives of polypeptides
A method for reducing or substantially preventing formation of a trisulfide derivative of a polypeptide in a liquid medium containing the polypeptide ijn question comprises stripping the liquid... |
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8513397 |
DNA replicon system for high-level rapid production of vaccines and monoclonal antibody therapeutics in plants
Plant viral vectors have great potential in rapid production of proteins, but no simple. Here a geminivirus-based system for high-yield and rapid production of oligomeric protein complexes,... |
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8507433 |
Cardioprotective effects of GHRH agonists
Whether the growth hormone (GH)/Insulin-like growth factor 1(IGF-I) axis exerts cardioprotective effects remains controversial; and the underlying mechanism(s) for such actions are unclear. Here... |
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8507245 |
Site-directed pegylation of arginases and the use thereof as anti-cancer and anti-viral agents
Mono-pegylated arginase conjugate and method producing thereof. The mono-pegylated arginase is homogeneous in molecular weight and shows therapeutic effect for treating cancers and viral... |
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8501918 |
Immobilized tumor necrosis factor-α muteins for enhancing immune response in mammals
The present invention provides a method for enhancing an immune response in a mammal to facilitate the elimination of a chronic pathology. The method involves the removal of immune system... |
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8481679 |
Immobilizing an entity in a desired orientation on a support material
The present invention relates to the identification and selection of attachment molecules that attach/immobilize an entity having a detectable activity or property on a support in an orientation... |
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8461110 |
Heterodimeric peptide compounds displaying NGF activity and their use to treat neurodegenerative disorders
Peptides having a structure characterized by the presence of two loops constrained in cyclic structure by the presence of covalent bonds between amino acid side chains, the amino acid sequences of... |
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8455445 |
Methods for inhibiting lymphotoxin-β receptor signaling in TH1 cell-associated disorders
This invention relates to compositions and methods comprising “lymphotoxin-β-receptor blocking agents”, which block lymphotoxin-β receptor signalling. Lymphotoxin-β receptor blocking agents are... |
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8431720 |
Indolesulfonyl protecting groups for protection of guanidino and amino groups
The invention relates to indolesulfonyl halogenides which are useful for the protection of organic compounds comprising at least one guanidino moiety and/or at least one amino group. The invention... |
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8415307 |
Antibiotic compositions for the treatment of gram negative infections
Provided herein are novel compounds and novel protected compounds that can be derived from polymyxin, including, e.g., polymyxin A. The novel compounds have antibacterial properties against a... |
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8404814 |
Anti-EDB antibody-targeted IL-10 cytokine for therapy of rheumatoid arthritis
The present invention relates to fusion proteins comprising an antibody, functional fragment or functional derivative thereof having specific binding affinity to either the extracellular domain of... |
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8372799 |
Reverse protein
A protein which is composed N-terminally of one or several C-terminal parts of the amino acid sequence of the mature tumor necrosis factor and C-terminally of one or several N-terminal parts of... |
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8361965 |
Recombinant chimeric protein of neutrophil inhibitory factor and hirugen, and pharmaceutical composition thereof
A chimeric protein containing neutrophil inhibitory factor and hirugen, the chimeric protein having an amino acid sequence that includes FPRPGSGG (SEQ ID NO:21) Also provided is a pharmaceutical... |
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8349805 |
Use of Gonadorelin as a therapeutic agent
The present invention is directed to the use of the peptide compound Pyr-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2 as a therapeutic agent for the prophylaxis and/or treatment of cancer, autoimmune... |
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8338380 |
Use of the peptide RFMWMR as a therapeutic agent
The present invention is directed to the use of the peptide compound Ac-Arg-Phe-Met-Trp-Met-Arg-NH2 as a therapeutic agent for the prophylaxis and/or treatment of cancer, autoimmune diseases,... |
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8330026 |
Derivatives of the NF-κB inducing enzyme, their preparation and use
The invention relates to the use of NF-κB inducing kinase (NIK) and related molecules for the modulation of signal activities controlled by cytokines, and some new such molecules. |
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8329637 |
Method for the treatment of automimmune diseases comprising administering rapamycin and IL-10
The invention discloses a combined preparation containing IL-10 and rapamycin, able to induce immunosuppression and antigen-specific immune tolerance, and the use thereof in the treatment of... |
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8324363 |
Microarray for detection of the deletion of exon 3 of the G-CSF gene
Disclosed are a method, a composition, a microarray, an antibody and a kit for diagnosis and prognosis of cancer, based on detection of deletion of the exon 3 region of G-CSF gene or levels of a... |