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8957239 Process for the eco-friendly preparation of 3, 5-dibromo-4-hydroxybenzonitrile  
A highly pure 3,5-dibromo-4-hydroxybenzonitrile (bromoxynil) has been prepared in high yield from 4-hydroxybenzonitrile using eco-friendly brominating reagent comprising of 2:1 mole ratio of...
8420235 Emissive diaryl acetylenes  
Disclosed herein are compounds represented by a formula: Compositions and light-emitting devices related thereto are also disclosed.
8378044 Living radical polymerization method using alcohol as catalyst  
Provided is a low-cost, environmentally friendly living radical polymerization catalyst having high activity. The catalyst is used for a living radical polymerization method, and contains a...
8314137 Monocyclic cyanoenones and methods of use thereof  
The present invention features monocyclic cyanoenone compositions and methods for using the same in the treatment of diseases such as cancer, inflammatory diseases and neurodegenerative diseases.
8063102 Tetrahydronaphthalen-2-ol derivatives  
The present invention relates to novel tetrahydronaphthalen-2-ol derivatives, to pharmaceutical compositions comprising these compounds and to their use in therapy, in particular to their use for...
8034955 Therapeutic compounds and methods of use  
Compounds and methods useful for chemopreventative treatment of diseases such as cancer, Alzheimer's disease, Parkinson's disease, inflammatory bowel diseases, and multiple sclerosis.
7977491 Dendron and dendrimer, method of producing the same, and method of producing a thioacetal compound  
A dendron or dendrimer, which has, as a recurring unit of each branch, a structure of formula (I): wherein TC designates a linkage to a former generation in the direction to a focal point of the...
7863327 Therapeutic compounds and methods of use  
Compounds and methods useful for chemopreventative treatment of diseases such as cancer, Alzheimer's disease, Parkinson's disease, inflammatory bowel diseases, and multiple sclerosis.
7732544 Titanium compound and process for producing optically active cyanohydrins  
The present invention relates to a titanium compound produced from a reaction mixture of a titanium tetraalkoxide compound with water and an optically active ligand represented by the following...
7718684 Methods and materials for assessing prostate cancer therapies and compounds  
A modest (2-5 fold) increase in androgen receptor (AR) mRNA is the only expression change consistently associated with developing resistance to antiandrogen therapy. Increased levels of AR confer...
7576128 Androgen receptor modulators  
The present invention is directed to a new class of 4-oxo-benzonitriles, their use as androgen modulators, and to their use in the treatment of alopecia.
7470806 Process for the synthesis of (7-methoxy-1-naphthyl) acetonitrile and its application in the synthesis of agomelatine  
A process for the industrial synthesis of the compound of formula (I) Application in the synthesis of agomelatine.
RE39682 Farnesyl derivatives and pharmaceutical compositions containing them  
Novel farnesyl derivatives which are inhibitors of the prenylated protein methyltransferase enzyme, and useful as anti-cancer drugs, have the following formula: wherein R1represents farnesyl,...
6914074 Substituted phenyl naphthalenes as estrogenic agents  
This invention provides estrogen receptor modulators of formula I, having the structure wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10, are as defined in the specification, or a...
6875882 Synthesis of benzonitriles from substituted benzoic acid  
There is a significant demand for organic nitriles, based on their versatility in reactions. Compounds prepared from nitriles have properties including superoxide inhibition, ferrielectric liquid...
6875895 Bis (diphenylvinyl) arene compound  
Provided is a bis(diphenylvinyl)arene compound having a reactive functional group on phenyl group, represented by below formula (1), wherein, Ar is an arylene group and has one or more...
6827876 Difluoromethyl ether derivative and process for producing the same  
A liquid crystalline compound represented by Formula (1c′): wherein R1 and R2, rings A1, A2, A3, A4 and A5, Z1, Z2, Z3 and Z4, Y1, Y2, Y3 and Y4, and k, l, m and n are as defined in the...
6790853 Contraception method using competitive progesterone antagonists and novel compounds useful therein  
Competitive progesterone antagonists, including two novel steroids, viz., 11β,19-[4-(cyanophenyl)-o-phenylene]-17β-hydroxy-17α-(3-hydr oxyprop-1(Z)-enyl)-4-androsten-3-one and...
6790977 Process for preparing 3,4-dihydroxy-benzonitrile  
A process for preparing 3,4-dihydroxybenzonitrile includes the steps of reacting a nitrile compound with an alkali metal halide, followed by treating with an acid.
6770463 Process for the preparation of chiral isofluoroenes  
There is provided a process for the preparation of a chiral insecticidal and acaricidal compound of formula I. Also provided are intermediate compounds useful in the process of the present invention.
6630509 Phenalkyloxy-phenyl derivatives  
The present invention relates to certain phenalkyloxy-phenyl derivatives of formula (I) and analogs, to a process for preparing such compounds, which compounds have utility in treating clinical...
6573397 Process for producing 3,4-dihydroxybenzonitrile  
3,4-dihydroxybenzonitrile useful as a starting compound for synthesis of medicines and agricultural chemicals is produced, with a high yield by chlorinating 3,4-methylenedioxybenzonitrile with...
6525092 Pesticidal bis-oxime compounds  
Bis-oxime compounds of the general formula (I) are provided wherein X, Y, R1, R2 R3 and n are as defined in the specification. The bis-oxime compounds possess pesticidal activity, which may...
6426422 Method for the preparation of citalopram  
Disclosed is a method for the preparation of citalopram comprising conversion of a compound of Formula VIII wherein Z is halogen, to a compound of Formula IV followed by conversion of the compound...
6379590 Method for making unsymmetrically substituted fluorenyl compounds for nonlinear optical applications  
A new method for producing unsymmetrically substituted fluorenyl compounds, one step of which is the preparation of 2,7-disubstituted fluoren-9-one derivatives via the nucleophilic substitution of...
6372933 Process for preparing certain phenyl urea compounds  
This invention relates to a process for making certain phenyl urea compounds by using a Lewis acid to effect the ring opening of a benzoxazolinone by an amine.
6340688 Contraception method using competitive progesterone antagonists and novel compounds useful therein  
Competitive progesterone antagonists, including two novel steroids, viz., 11β,19-[4-(cyanophenyl)-o-phenylene]-17β-hydroxy-17α-(3-hydr oxyprop-1(Z)-enyl)-4-androsten-3-one and...
6326507 Therapeutic compounds and methods of use  
Compounds and methods useful for chemopreventative treatment of diseases such as cancer, Alzheimer's disease, Parkinson's disease, inflammatory bowel diseases, and multiple sclerosis.
6291689 Method for the preparation of citalopram  
A method for the preparation of citalopram is described comprising reduction of the oxo group of a compound of formula (IV), ##STR1##wherein R1 is CN, C1-6 alkyloxycarbonyl or C1-6...
6288262 Process for the preparation of 2-methoxyethoxy-benzenes and novel 2-methoxyethoxy-benzyl cyanides  
2-Methoxyethoxy-benzenes are obtained in an advantageous manner from the corresponding phenol compounds by reaction with 2-chloroethyl methyl ether if the process is carried out without the...
6288260 Process for making 2-alkyl-3-hydroxybenzoic acids  
A two step process is described for making 2-alkyl-3-hydroxybenzoic acids or derivatives of benzoic acids by first reacting an allenyl ester or equivalent with furan followed by the ring-opening...
6211234 Substituted phenyl compounds  
Compounds of formula (I) are described wherein R1 is hydrogen, -(lower alkyl)q (CO2 R6 or OH), --CN, --C(R7)NOR8, NO2, --O(lower alkyl)R9, --C.tbd.C--R10, --CR11C(R12)(R13), --C(O)CH2 C(O)CO2...
RE37087 Insecticidal triffluormethyl alkane derivatives  
There are provided new alkane and alkoxyalkane derivatives of the general formula I ##STR1##in which R1, R2, R3, R4 and A have the meanings given in the description, processes for their...
6187945 Process for producing cyanobenzyl compounds  
An industrially advantageous process for producing cyanobenzyl compounds under mild conditions from relatively easily available cyanobenzylamine having a cyano group on the benzene ring or a...
6184249 Androgen receptor suppressors in the therapy and diagnosis of prostate cancer, alopecia and other hyper-androgenic syndromes  
Substituted phenylalanines are provided comprising an hydantoin, urea or 2-hydroxyl, 2-methylpropionyl group, dimers thereof and alkyl, polyfluoroamido and haloarylamino derivatives thereof, as...
6166226 Synthesis of aryl ethers  
A method for preparing an aryl ether compound is provided in which an alcohol is reacted with an aromatic compound in the presence of a base, and a transition metal catalyst selected from the...
6160157 Preparation of 4-cyano-4'-hydroxybiphenyl  
The invention relates to a preparation process for 4-cyano-4'-hydroxybiphenyl, said process comprising the protection of the hydroxy group of 4-phenyl-phenol, acylation of the protected...
6150304 2-aryl-cyclopentane-1,3-dione derivatives  
The present invention relates to novel 2-aryl-3-hydroxy-cyclopent-2-en-1-one derivatives of the formula (I) ##STR1## in which X represents halogen, nitro, cyano, alkyl, alkoxy, alkenyloxy,...
6143311 Iodopropargyl derivatives and antimicrobial agents comprising them as an active ingredient  
The present invention provides novel iodopropargyl derivatives represented by the following formula (1): ##STR1## wherein R1 is a methoxy group or a cyano group, which have a reduced unpleasant...
6121480 Method for producing unsymmetrically substituted biphenyls  
The invention concerns a method for the production of unsymmetrically substituted cyanobiphenyls by the slow addition of an aryl Grignard compound to an optionally substituted bromobenzonitrile in...
RE36849 Anisotropic compounds and liquid crystal mixtures therewith  
Anisotropic compounds of the formula (1) specified in claim 1 are suitable, owing to their low Δε/ε⊥ values for liquid crystal displays which have high information densities of for examples up to...
6090969 Process for the preparation of an asymmetric compound using a metal complex  
A process for producing an asymmetric compound using a metal complex containing no rare earth metal element is disclosed. The process affords an optically active compound having high optical...
6008400 Orthoester reagents for use as protecting groups in oligonucleotide synthesis  
Phosphoramidite oligonucleotide synthesis is facilitated by the use of fluoride-labile 5' silyl protecting groups. RNA synthesis is improved by the use of 2 orthoester protecting groups. Reactions...
6008401 Process for producing an optically active compound  
A process is disclosed for producing an optical active alkoxybenzonitrile derivative in which process a benzonitrile derivative is subjected to condensation reaction with an optical active...
5998673 1, 4-diaryl-2-fluoro-2-butene insecticidal and acaricidal agents  
Pesticidal 1,4-diaryl-2-fluoro-2-butene compounds having the structural formula I ##STR1## and compositions and methods comprising those compounds for the control of insect and acarid pests.
5984975 3-substituted para-aminophenols and use thereof in dyeing keratinous fibers  
A method or composition for dyeing keratinous fibres using as an oxidation dye precursor a 3-substituted para-aminophenol of formula: ##STR1## where R1 represents alkyl, alkenyl, mono- or...
5965766 Process for synthesizing benzoic acids  
Nucleophilic substitution reactions on halobenzenes or triflyl substituted benzenes are carried out in the presence of catalysts. In particular the present invention provides a process leading to...
5952386 Dihalopropene compounds, insecticides containing them as active ingredients, and intermediates for their production  
The present invention provides dihalopropene compounds of the general formula: ##STR1## wherein R1 is C1 -C10 alkyl or the like; L is C(O)NH or the like; R2, R3 and R4 are independently halogen...
5917079 Process for synthesizing benzoic acids  
Nucleophilic substitution reactions on halobenzenes are carried out in the presence of catalysts. In particular the present invention provides a process leading to optionally substituted...
5883283 Process for the preparation of substituted 3-aminobenzonitriles  
The invention relates to a process for the preparation of substituted 3-amninobenzonitriles, which comprises reacting the appropriate substituted 3-aminochlorobenzene with a cyano-donating...

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