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9000110 Fluoroalkyl group-containing n-substituted (meth)acrylamide compound, polymer thereof, and use thereof  
A compound represented by the following formula (a): CH2═CR1—CONJ-CGR2—(CH2)n—COO-Q1-Rf1 (a) is provided. This compound is capable of forming a polymer having an oil repellency equivalent to...
8957061 Azetidine derivatives as sphingosine 1-phosphate (S1P) receptor modulators  
The present invention relates to novel azetidine derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of...
8927527 Cyclic nitro compounds, pharmaceutical compositions thereof and uses thereof  
The present invention provides cyclic nitro compound, pharmaceutical compositions of cyclic nitro compounds and methods of using cyclic nitro compounds and/or pharmaceutical compositions thereof...
8906899 Azetidine derivatives as sphingosine 1-phosphate (S1P) receptor modulators  
The present invention relates to novel azetidine derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of...
8889683 Substituted quinoxalines as inhibitors of fatty acid binding protein  
The present invention relates to novel quinoxaline compounds of Formula I: as Fatty Acid Binding Protein (“FABP”) inhibitors, pharmaceutical compositions comprising the quinoxaline compounds and...
8871755 Alkene azetidine derivatives as sphingosine 1-phosphate (S1P) receptor modulators  
The present invention relates to alkene azetidine derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of...
8859550 Heterocyclic inhibitors of histamine receptors for the treatment of disease  
The present invention relates to salts, hydrates, and polymorphs of bicyclic heteroaryl compounds, and pharmaceutical compositions thereof, which may be useful as inhibitors of H4R for the...
8853392 Benzamide mGluR5 positive allosteric modulators and methods of making and using same  
In one aspect, the invention relates to compounds, including phenylethynylbenzamide derivatives, cycloalkylethynylbenzamide derivatives, styrylbenzamide derivatives,...
8828985 Carbamate and urea inhibitors of 11-beta-hydroxysteroid dehydrogenase 1  
This invention relates to novel compounds of the Formula (I) pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of...
8809552 Azetidine compounds, compositions and methods of use  
Provided are compounds of Formula I, R1-L1-A-L2-R2 (I), and stereoisomers, tautomers and pharmaceutically acceptable salts thereof, wherein A, L1, L2, R1 and R2 are defined herein. The present...
8802659 Bicyclic aryl sphingosine 1-phosphate analogs  
Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at S1P receptors.
8791100 Aryl benzylamine compounds  
The present invention relates to substituted aryl-benzylamine compounds, to processes for their production, to their use as pharmaceuticals and to pharmaceutical compositions comprising them.
8759533 Di-azetidinyl diamide as monoacylglcerol lipase inhibitors  
Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows:...
8759333 Di-azetidinyl diamide as monoacylglycerol lipase inhibitors  
Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows:...
8759334 Compounds useful for the treatment of metabolic and inflammatory diseases  
Compounds are disclosed that have a formula represented by the following: These compounds may be prepared as a pharmaceutical composition, and may be used for the prevention and treatment of a...
8697682 Salts  
This invention relates to a hydrochloride, malate, oxalate and tartrate salt forms of 1-(4-{1-[(E)-4-cyclohexyl-3-trifluoromethyl-benzyloxyimino]- ethyl}-2-ethyl-benzyl)-azetidine-3-carboxylic...
8685958 Therapeutic agents  
Disclosed herein are azetidinyl compounds of formula I, as described herein, pharmaceutical compositions comprising an azetidinyl compound, and a method of using an azetidinyl compound in the...
8664213 Spiro bicyclic diamine derivatives as HIV attachment inhibitors  
Compounds of Formula I, including pharmaceutically acceptable salts thereof: wherein A is selected from the group consisting of: are useful as HIV attachment inhibitors.
8653062 Compounds as receptor modulators with therapeutic utility  
The present invention relates to novel cyclic amine and cycloalkyl derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as...
8623856 Phenoxy-azetidine derivatives as sphingosine 1-phosphate (S1P) receptor modulators  
The present invention relates to novel phenoxy-azetidine derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of...
8614332 Substituted pyrazolylamides useful as glucokinase activators  
Compounds are provided which are phosphonate and phosphinate activators and thus are useful in treating diabetes and related diseases and have the structure is a heteroaryl ring; R4 is...
8575349 Derivatives of 1-alkyl-6-oxo-piperidine-3-carboxylic acids and 1-alkyl-5-oxo-pyrrolidine-3-carboxylic acids and their uses as cooling compounds  
The present invention relates to novel derivatives of 1-alkyl-6-oxo-piperidine-3-carboxylic acids and 1-alkyl-5-oxo-pyrrolidine-3-carboxylic acids represented by Formula I: wherein n is an integer...
8569300 Substituted tetrazolo[1,5-A]pyrazine inhibitors of histamine receptors for the treatment of disease  
The present invention relates to substituted tetrazolo[1,5-a]pyrazine compounds for Formula IX: as well as pharmaceutical compositions thereof, which may be useful as inhibitors of H4R for the...
8563714 Bridged spiro [2.4] heptane derivatives as ALX receptor and/or FPRL2 agonists  
The present invention relates to bridged spiro[2.4]heptane derivatives of formula (I), wherein W, Y, Z, R1 and R2 are as defined in the description, their preparation and their use as...
8530461 Azetidine derivatives  
Azetidine derivatives of which the following is exemplary and their use in the treatment of obesity, diabetes or dyslipidemia.
8518932 Oxime azetidine derivatives as sphingosine 1-phosphate (S1P) receptor modulators  
The present invention relates to novel oxime azetidine derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of...
8513229 4-Azetidinyl-1-phenyl-cyclohexane antagonists of CCR2  
The present invention comprises compounds of Formula (I): wherein: X, R1, R2, R3, and R4 are as defined in the specification. The invention also comprises a method of preventing, treating or...
8501726 Azetidine derivatives as sphingosine 1-phosphate (S1P) receptor modulators  
The present invention relates to novel azetidine derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of...
8492372 Modulators of dopamine neurotransmission  
The present invention relates to novel 1-(4H-1,3-benzodioxin-2-yl)methanamine derivatives, useful as modulators of dopamine neurotransmission, and more specifically asdopaminergic stabilizers. In...
8486930 Salts  
This invention relates to a hydrochloride, malate, oxalate and tartrate salt forms of 1-(4-{1-[(E)-4-cyclohexyl-3-trifluoromethyl-benzyloxyimino]- ethyl}-2-ethyl-benzyl)-azetidine-3-carboxylic...
8471041 Methods of synthesizing and isolating N-(bromoacetyl)-3,3-dinitroazetidine and a composition including the same  
A method of synthesizing and isolating N-(bromoacetyl)-3,3-dinitroazetidine (ABDNAZ) by reacting DNAZ with bromoacetyl bromide and boron trifluoride etherate to produce a mixture comprising ABDNAZ...
8450304 4-azetidinyl-1-heteroaryl-cyclohexanol antagonists of CCR2  
The present invention comprises compounds of Formula (I). wherein: R1, R2, R3, and R4 are as defined in the specification. The invention also comprises pharmaceutical compositions comprising the...
8394787 7-aza-spiro[3.5]nonane-7-carboxylate derivatives, preparation thereof and therapeutic use thereof  
The invention relates to compounds of the general formula (I) where: R2 is a hydrogen or fluorine atom or a hydroxyl, cyano, trifluoromethyl, C1-6-alkyl, C1-6-alkoxy, or NR8R9 group; m, n, o and p...
8383615 Azetidine 2-carboxamide derivatives which modulate the CB2 receptor  
Compounds of the formula (I), (II) and (III) which modulate the CB2 receptor are disclosed. Compounds according to the invention bind to and are agonists of the CB2 receptor, and are useful for...
8338623 Compounds as cannabinoid receptor ligands  
The present application relates to cannabinoid receptor ligands containing compounds of formula (I) wherein A, R1, R2, and R3 are as defined in the specification. The present application also...
8299053 Cyclic nitro compounds, pharmaceutical compositions thereof and uses thereof  
The present invention provides cyclic nitro compound, pharmaceutical compositions of cyclic nitro compounds and methods of using cyclic nitro compounds and/or pharmaceutical compositions thereof...
8273902 Process for production of 1-(3-(2-(1-benzothiophen-5-yl)-ethoxy)propyl)azetidin-3-ol or salts thereof  
A Process for production of 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or salts thereof which comprises using as a starting compound as a (phenylthio)acetic acid derivative or salts...
RE43676 Alkyl ether derivatives or salts thereof  
An alkyl ether represented by the general formula: or its salt. This compound has activity to protect neurons, activity to accelerate nerve regeneration and activity to accelerate neurite...
8236792 Substituted pyrrolidine amides as modulators of the histamine H3 receptor  
Certain substituted pyrrolidine amide compounds are histamine H3 receptor modulators useful in the treatment of histamine H3 receptor-mediated diseases.
8232269 Amide compounds useful in therapy  
A compound of Formula (I), or a pharmaceutically acceptable salt or solvate thereof, wherein, R1 and R2 each independently represent H, halogen, CF3, C1-3 alkyl or C1-3 alkoxy;R3 represents C1-6...
8207355 Method for preparing azetidine derivatives  
This invention discloses and claims an industrial method for the production of azetidine derivatives, such as, N-(1-benzhydrylazetidin-3-yl)-N-phenylmethylsulphonamide.
8207155 Sulfonyl-azetidin-3-yl-methylamine amide analogs as GlyTl inhibitors, methods for making same, and use of same in treating psychiatric disorders  
In one aspect, the invention relates to compounds which are useful as inhibitors of glycine type 1 transporter (GlyT1) activity; synthetic methods for making the compounds; pharmaceutical...
8188090 Naphthylacetic acids  
The invention is concerned with the compounds of formula I: and pharmaceutically acceptable salts and esters thereof, wherein X, Q and R1-R3 are defined in the detailed description and claims. The...
8178698 Methods of synthesizing cyclic nitro compounds  
The present invention provides cyclic nitro compounds, pharmaceutical compositions of cyclic nitro compounds and methods of using cyclic nitro compounds and/or pharmaceutical compositions thereof...
8173634 Polymorphic form of 1-(4-{1-[(E)-4-cyclohexyl-3-trifluoromethyl-benzyloxyimino]-ethyl}-2-ethyl-benzyl)-azetidine-3-carboxylic  
This invention relates to a novel crystalline form (Form A) of 1-(4-{1-[(E)-4-cyclohexyl-3-trifluoromethyl-benzyloxyimino]- ethyl}-2-ethyl-benzyl)-azetidine-3-carboxylic acid (Compound I), to...
8106191 Synthetic multimerizing agents  
New compounds are disclosed for multimerizing immunophilins and proteins containing immunophilin or immunophilin-related domains. The compounds are of the formula M-L-Q where M is a synthetic...
8093252 Crystalline polymorphic form of glucokinase activator  
A new polymorphic form of 3-{[5-(azetidin-1-ylcarbonyl)pyrazin-2-yl]oxy}-5-{[(1S)-1-me thyl-2-(methyloxy)ethyl]oxy}-N-(5-methylpyrazin-2-yl)benzami de, processes for making it and its use as an...
8080541 Carbocyclic GlyT-1 receptor antagonists  
The present invention relates to the use of a compound of formula I wherein R1, R2, R3, R4, X and n are as defined herein or to a pharmaceutically acceptable acid addition salt, to a racemic...
8080542 S1P receptor modulating compounds and use thereof  
The present invention relates to amides that have activity as SIP receptor modulating agents and the use of such compounds to treat diseases associated with inappropriate S1P receptor activity....
8076481 Chemical process 632  
A process for preparing pharmaceutically active compounds of formula (I) or a salt thereof wherein R1, n, m, R3, R6, X1, X2, X3 and X4 are as defined in the specification, is described. Novel...

Matches 1 - 50 out of 299 1 2 3 4 5 6 >