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8895743 Methysergide derivatives  
Provided herein are novel methysergide derivatives and compositions thereof. In other embodiments, provided herein are methods of treatment, prevention, or amelioration of a variety of medical...
8324386 Somatostatin-dopamine chimeric analogs  
Disclosed is a series of somatostatin-dopamine chimeric analogs which retain both somatostatin and dopamine activity in vivo. An example is:...
7939665 Efficient process for the preparation of cabergoline and its intermediates  
This invention relates to a new and efficient process for the production of dopamine agonists such as Cabergoline and the intermediates thereof.
7858791 Process for the preparation of cabergoline  
A process for preparing cabergoline (I) from ergoline-8β-carboxylic acid ester (XIII) comprising the following steps. (XIII), (XVI), (XVII), (XVIII), (XIX), (I). The present case also relates to...
7622476 Methods of using 1-allyl ergot alkaloid derivatives to treat migraines  
This invention relates to 1-allyl ergot alkaloids and their derivatives with selective antagonistic properties to 5-HT2 receptors for the prevention of, and relief from, migraine-related headache,...
7541463 Sulfur-containing naphthalimide derivatives  
The invention discloses novel sulfur-containing naphthalimide derivatives, and the preparation and uses thereof. The conjugated plane of naphthalimide derivatives of the invention is enlarged by...
7531551 Polymorphs of cabergoline  
Provided are new crystalline Forms VIII, IX, XI, XII, XIV, XV, XVI, XVII, and XVIII of cabergoline. Also provided are novel processes for preparation of cabergoline Form I, Form II, Form VII, and...
7339060 Preparation of cabergoline  
A method of preparing cabergoline Form I, comprising forming a solvate including cabergoline and a p-disubstituted benzene of formula (A) or 1,3,5-trimethylbenzene and obtaining cabergoline Form I...
7238810 Preparation of cabergoline  
A method of preparing cabergoline Form I, comprising forming a solvate including cabergoline and 4-fluorotoluene or 1,3,5-trimethylbenzene and obtaining cabergoline Form I from the solvate....
7186837 Preparation of cabergoline  
The present invention discloses a method for preparing cabergoline form I by combining cabergoline and a solvent comprising ethylbenzene to form a solvate and obtaining form I from the solvate....
7026483 Forms of cabergoline  
The invention provides methods for preparing amorphous physical form of cabergoline, and solvate form A of cabergoline useful in the preparation of the first mentioned physical form. A method for...
7019140 Process for the synthesis of pergolide  
A process for the synthesis of pergolide (Formula (I)) (D-6-n-propyl-8βmethylmercaptomethylergo line) from acid 9,10-dihydrolysergic is herein disclosed. The process can be carried out without...
6953854 Process for preparing crystalline Form I of cabergoline  
A process for producing crystalline form I of cabergoline, which process comprises crystallization of the desired form from a toluene/diethyl ether mixture comprising raw cabergoline, followed by...
6727363 Process for preparing crystalline form I of cabergoline  
A process for producing crystalline form I of cabergoline, which process comprises crystallization of the desired form from a toluene/diethyl ether mixture comprising raw cabergoline, followed by...
6680327 Crystalline form VII of cabergoline  
Crystalline form VII of cabergoline, a pharmaceutical composition containing it and a process for its preparation are disclosed. The process may comprise a slurry procedure using form I or mixture...
6395901 Process for the preparation of alkyl mercapto methyl ergoline derivatives  
Process for the preparation of compounds active in the treatment of Parkinson's disease, and such compounds, having general formula (VI) wherein R4 may be, independently, a linear, branched or...
6388079 Process for preparing pergolide  
This invention relates to a process for preparing pergolide, which comprises the steps of reacting 9,10-dihydrolysergol with an acid anhydride at an elevated temperature in the presence of a...
6358967 Ergoline amine derivatives with blood pressure lowering effect  
The invention relates to novel derivatives of ergoline of the general formula 1 in which R1 together with the two adjacent N atoms is the residue of a diamine and R4 together with the two adjacent...
6242603 Process of preparing lysergic acid  
The present invention relates to a novel process for preparing lysergic acid by isomerizing paspalic acid, using a tetraalkylammonium hydroxide.
6087371 Heterocyclyl-ergoline derivatives as 5-HT1A receptor ligands  
Ergoline derivative having formula (I) wherein R1 is hydrogen atom or C1-4 alkyl group; R2 is hydrogen, chlorine, or bromine atom, methyl or C1-4 alkylthio group; n is 0, 1 or 2; the substituent...
6060483 Antineurodegenerative ergoline derivatives  
PCT No. PCT/EP97/02955 Sec. 371 Date Dec. 28, 1998 Sec. 102(e) Date Dec. 28, 1998 PCT Filed May 29, 1987 PCT Pub. No. WO98/00424 PCT Pub. Date Jan. 8, 1998The present invention provides the new...
5831114 Carbamate herbicides  
Substituted N-phenyl- and N-heteroarylalkylcarbamates of formula (I), in which Q is a group (1), (2) or (3); R is halogen, trifluoromethyl, cyano, nitro or C1 -C3 haloalkoxy; Z is hydrogen or...
5480885 Ergoline derivatives of 1-propinylamine, a process for the manufacture thereof and the use thereof for medicaments  
A method of treating psychosis including administering an antipsychotically effective amount of an ergolinyl derivative of 2-propinylamine of the formula I ##STR1## wherein, R1, R2, and R3...
5430031 Serotoninergic ergoline derivatives  
The present invention provides compounds of the formula (I) ##STR1## wherein A, R1, R2 and R3 are defined as in the specification, or a pharmaceutically acceptable salt thereof. A process for...
5401748 2,14-disubstituted ergolines, their production and use in pharmaceutical compositions  
2,14-Disubstituted ergolines of formula I ##STR1## in which R, R2, R6, R14 and X have the meaning named in the application, as well as their production and use in pharmaceutical agents, are described.
5288724 Ergoline derivatives of 2-propinylamine, a process for the manufacture thereof and the use thereof for medicaments  
There are disclosed novel ergoline derivatives of 2-propinylamine of the general formula I ##STR1## wherein R1, R2 and R3 independently represent a hydrogen atom or a straight-chain or...
5219862 8 beta-substituted ergolines, process for their production and their use  
Compounds of formula I ##STR1## in which R2 means optionally substituted C1-7 alkyl, C2-7 alkenyl, CH2 --O--C1-4 alkyl or CH2 --S--C1-4 alkyl R6 means C2-6 alkyl, C3-6 alkenyl or C3-5...
5097031 Steroselective hydrogenation process  
The invention relates to a novel stereoselective process for the preparation of dihdyrolysergol from lysergol by hydrogenation in the presence of solvent and palladium catalyst applied on a...
5063234 Method of inhibiting demineralization of bone  
A method of inhibiting bone demineralization comprising administration of an effective amount of a compound having the formula ##STR1## where X is CH or N; Y is O or S; R1 is 2-propenyl, C1 -C3...
4980475 Process for the preparation of N-10 alpha-methoxyl-lumilysergol and esters, thereof, and intermediates for their preparation  
Processes for the preparation of esters of N1 -methyl-10α-methoxylumilysergol are described, in which lysergol esters are subjected to N-methylation and subsequently to photochemical reaction with...
4968801 Process for the production ergoline derivatives  
Ergoline derivatives of general Formula I ##STR1## wherein C8 C9 and C9 C10 are both CC-single bonds or one is a CC-double bond, R6 is C1-4 alkyl, R8 is methyl, hydroxymethyl, carbonylmethoxy,...
4939258 Cycloalkanol esters of dihydrolysergic acid  
Cycloalkyl or ketocycloalkyl esters of 1-substituted-6-C1-4 straight chain alkyl (or allyl)-ergoline-8β-carboxylic acids, useful as 5HT receptor antagonists.
4908449 Process for preparing N-methyl derivatives of lysergol and 10α-methoxylumilysergol  
A process for preparing 1-methyllysergol or 10α-methoxy-1-methyllumilysergol, which comprises adding a base, which is an alkali metal hydride or alcoholate, to a solution of lyergol or...
4874768 1,2-disubstituted ergolines useful for producing central antidopanminergic or α2-receptor-blocking activity  
The disclosure relates to 1,2-substituted ergoline derivatives of general Formula I ##STR1## wherein X is an oxygen or sulfur atom, R1 is a lower alkyl group, R2 is halogen, acyl, a saturated or...
4870179 Process for preparing lysergol derivatives  
A method of preparing lysergol derivatives, particularly 10α-methoxy lumilysergol, 1-methyl-10α-methoxy-lumilysergol and C8 esters of 1-methyl-10α-methoxy-lumilysergol, is provided characterized...
4859682 2-Halogenated-8- and 1,8-substituted ergolenes  
The invention relates to novel 2-halogenated 8- and 1,8-substituted ergolene derivatives of the formula (I) and the acid addition salts thereof, pharmaceutical compositions containing them and a...
4859678 N-oxide ergolines as antihypertensive agents  
An ergoline derivative of the formula I: ##STR1## wherein R1 represents hydrogen or a methyl group; R2 represents hydrogen or a halogen atom, a methyl, cyano or phenyl group or an alkylthio group...
4847262 2-substituted ergolines having neuroleptic and antidepressant activities  
Novel ergoline derivatives, substituted in the 2-position, of the formula ##STR1## wherein C8 ---C9 and C9 ---C10 each independently is a CC-single or a CC-double bond, but not together a...
4843073 1-t-butyl ergolines useful in the treatment of cerebral insufficiency and senile dementia  
t-Alkyl ergoline derivatives of formula I are produced ##STR1## wherein (R1 =H, OCH3 and R2 =H) or (R1 +R2 =a ring bond and R3 =H, optionally substituted nicotinoyl or 1-oxo-2-cyclopenten-3-yl);...
4839363 Ergolinyl heterocycles for the treatment of Parkinson's disease and dyskinetic symptoms  
Ergoline derivatives of the formula I ##STR1## wherein R1 represents a hydrogen atom or a methyl group; R2 represents a hydrogen atom or a methoxy group; R3 represents a hydrocarbon group having...
4816587 Process for the preparation of 2-halogenated ergoline derivatives  
The invention relates to a novel process for the halogenation in 2-position of ergot alkaloids. The process is characterized by that as a halogenating agent a system consisting of...
4801714 Process for the preparation of ergolinylthioureas  
Ergolinylthioureas derivatives of the general Formula I ##STR1## wherein R1 is hydrogen, lower alkyl or acyl, R2 is hydrogen, halogen or a lower alkylthio group R3 is lower alkyl, R4, R5 and R6,...
4801712 2-Alkyl(or phenyl)thio-6-n-alkylergolines are dopamine D-1 antagonists without D-2 agonist activity  
D-2-Alkyl(or phenyl)thio-6-n-alkylergolines or ±-2-alkyl(or phenyl)thio-4-dialkylaminotetrahydrobenz[c,d]indoles, dopamine D-1 antagonists.
4798834 Optionally substituted (3β-9,10-didehydro-2,3-dihydro ergoline as serotonergic function enhancement  
A therapeutic method employing 2,3-dihydroergolines is disclosed. Said method enhances serotonergic function in the nervous system of a mammal in need thereof, thereby finding application in...
4797405 Stabilized pergolide compositions  
Pharmaceutical compositions containing pergolide or a salt thereof stabilized to decomposition by light by incorporation therewith of a stabilizing agent selected from polyvinylpyrrolidone,...
4785001 Ergoline esters  
Ergoline Esters having the formula (I) ##STR1## in which R1 =H or CH3 ; R2 =C1 -C4 hydrocarbon; R3 =H or OCH3 ; R4 =H or halogen; R5 =C1 -C4 alkyl and their pharmaceutically acceptable salts are...
4782152 Decyanation of pergolide intermediate  
The present invention provides a process for decyanating a pergolide intermediate with an alkali metal hydroxide in an alcoholic solvent having a boiling point greater than about 100° C. at a...
4772709 Process of making ketoalkanol esters of dihydrolysergic acid  
Ketoalkyl esters of 1-substituted-6-C1-4 straight chain alkyl (or allyl)ergoline-8β-carboxylic acid, useful and 5HT receptor antagonists.
4753949 2-chloronicergoline having antihypoxic activity  
The invention relates to a novel process for the preparation of partially new 2-halonicergoline derivatives of the formula (I), ##STR1## wherein X stands for chlorine, bromine or iodine atom, as...
4754037 Process for preparing N-methyl derivatives of ergoline  
A process for preparing an N-methyl derivative of ergoline of formula: ##STR1## in which R1 denotes a carboxy or alkoxycarbonyl group in which the alkyl portion contains 1 to 4 carbon atoms, R2...

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