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8987280 Pyrazolopyrimidine PI3K inhibitor compounds and methods of use  
Compounds of Formula I, and including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting lipid kinases...
8884062 Aminodihydrothiazine derivatives substituted with a cyclic group  
This invention provides a compound of the formula (I): wherein the ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; R1 is optionally...
8653067 Pharmaceutical composition for treating Alzheimer's disease  
A pharmaceutical composition for treating Alzheimer's disease containing a compound represented by the general formula (I); wherein ring A is an optionally substituted carbocyclic group or an...
7659280 2,4-pyrimidinediamine compounds for treating or preventing autoimmune diseases  
The present invention provides 3-hydroxyphenyl-2,4-pyrimidinediamine compounds of formula I, as well as related compositions and methods for treating a variety of autoimmune diseases.
7572824 Methods for minimizing thioamide impurities  
Methods for minimizing the formation of thioamide compounds using decoy agents during reactions, such as thionations of carbonyl compounds containing nitrile groups, and the products thereby are...
7420053 2-imino-1,3-thiazine derivatives  
The present invention relates to 2-imino-1,3-thiazine derivatives, in specific, 2-imino-1,3-thiazine derivatives having a selective antagonistic activity or agonistic activity to a cannabinoid...
7314932 Methods for minimizing thioamide impurities  
Methods for minimizing the formation of thioamide compounds using decoy agents during reactions, such as thionations of carbonyl compounds containing nitrite groups, are provided.
7223754 Thiazolidinone, oxazolidinone, and imidazolone derivatives for treating lower urinary tract and related disorders  
The invention relates to methods of using Cav2.2 subunit calcium channel modulators, particularly thiazolidinone, oxazolidinone, and imidazolone derivatives, to treat lower urinary tract and...
7183275 2-imino-1,3-thiazine derivatives  
The present invention relates to 2-imino-1,3-thiazine derivatives, in specific, 2-imino-1,3-thiazine derivatives having a selective antagonistic activity or agonistic activity to a cannabinoid...
7166590 Amino acid derivatives  
A compound of the formula (I): [wherein R1 is (substituted) alkyl, alkoxy, phenyl, hetero ring etc.; A is bond, CO, SO2; R2 is H, (substituted) alkyl etc.; D is alkylene etc.; E is COO, OCO, O, S,...
7094778 Heterocyclylalkylamines as muscarinic receptor antagonists  
This invention relates to compounds which are generally muscarinic M2/M3 receptor antagonists and which are represented by Formula I: wherein X, Y, and Z are O, S or NR5, and the other...
RE39130 Heterocyclic compounds  
Novel heterocyclic compounds of the formula wherein, R1 represents a hydrogen atom or an alkyl group, A represents an ethylene group which may be substituted by alkyl or a trimethylene group which...
7015217 Cyclic sulfone derivatives as inhibitors of matrix metalloproteinases and/or TNF-α converting enzyme (TACE)  
The present application describes novel cyclic sulfone derivatives of formula I: or pharmaceutically acceptable salt or prodrug forms thereof, which are useful as inhibitors of matrix...
6936606 Cyanoamido-containing heterocyclic compounds useful as reversible inhibitors of cysteine proteases  
Disclosed are novel cathepsin S, K, F, L and B reversible inhibitory compounds of the formulas (Ia) and (Ib) where R1, R2, R3, R4, R5, R6, R8, R9 and X are defined herein. The compounds are useful...
6818640 2-imino-1,3-thiazine derivatives  
It is found out that compounds represented by general formula (I) bind selectively to cannabinoid 2 receptor (CB2R) and thus exhibit CB2R antagonism or CB2R agonis wherein R1 represents optionally...
6794406 Indole derivatives  
The invention relates to new indole derivatives, processes for their preparation, and their use in medicaments.
6787522 Antibacterial agents  
Compounds of formula (I) are antibacterials: wherein:R1 represents hydrogen, or C1-C6 alkyl or C1-C6 alkyl substituted by one or more halogen atoms; R2 represents a group R10—(X)n—(ALK)m— wherein...
6673804 Sulfonamide derivatives  
A compound of the formula (I) or a pharmacologically acceptable salt, ester or other derivative thereof: R1 is H or NHOH. R2 is H, optionally substituted alkyl, cycloalkyl or a group —AR6.A is an...
6670359 Substituted chroman derivatives  
The present invention relates to new new piperidyl- or piperazinyl-substituted dihydro-2H-1-benzopyran derivatives compound having the formula (I) whereinX is N or CH;Y is NR2CH2, CH2NR2, NR2CO,...
6656911 Serine protease inhibitors  
The present invention relates to certain substituted oxadiazole, thiadiazoles and triazole peptoids which are useful as inhibitors of serine proteases. Compounds of the invention are useful for...
6642180 Biphenyl-substituted cyclic ketoenols as pesticides  
The present invention relates to novel biphenyl-substituted cyclic ketoenols of the formula (I) in whichW represents hydrogen, halogen, alkyl, alkoxy, alkenyloxy, halogenoalkyl, halogenoalkoxy,...
6605608 Amino acid derivatives and drugs containing the same as the active ingredient  
The present invention relates to the compounds of the formula (I) and salts thereof (all the symbols are the same meanings as described in the specification). The compounds of the formula (I)...
6559155 Pyrimidinone derivatives for the treatment of atherosclerosis  
Pyrimidones of formula (I) are inhibitors of the enzyme LpPLA2 and thereof use in treating inter alia atherosclerosis, in which:R1 is COOH or a salt thereof, COOR10, CONR11R12, CN or CH2OH;R2 is a...
6485868 Electrolyte for electrochemical device  
The invention relates to an electrolyte for an electrochemical device. This electrolyte includes an ionic metal complex represented by the general formula (1): wherein M is an element of groups...
6469000 1,3-diheterocyclic metalloprotease inhibitors  
Disclosed are compounds which are inhibitors of metalloproteases having the following structure: where Ar, W, X, Y, Z, R1 and R2 have the meanings described in the specification and optical...
6410482 (Het) arylsulfonylureas having an amino function, their presentation and their use as herbicides and plant growth regulators  
(Het)Arylsulfonylureas having an imino function, their preparation, and their use as herbicides and plant growth regulators Compounds of the formula (I) and salts thereof in which A is a...
6407232 Ionic metal complex and process for synthesizing same  
The invention relates an ionic metal complex represented by the general formula (1): wherein M is an element of groups 3-15 of the periodic table; Aa+ represents a metal ion, onium ion or proton;...
6395730 Potassium channel inhibitors  
Certain thiazolidinone and metathiazanone compounds, as described, are useful as potassium channel inhibitors and are especially useful for the treatment of cardiac arrhythmias and other diseases,...
6365587 Substituted aryl hydroxamic acids as metalloproteinase inhibitors  
The present application describes novel substituted aryl hydroxamic acids of formula I: or pharmaceutically acceptable salt forms thereof, wherein ring A is a 5-8 membered ring containing from 0-1...
6268311 1-Amino-3-benzyluracils  
1-Amino-3-benzyluracils I ##STR1##(X=oxygen, sulfur; R1 =C1 -C4 -haloalkyl; R2 =H, halogen; R3, R7 =H, CN, SCN, halogen, C1 -C4 -haloalkyl, C1 -C4 -haloalkoxy, C1 -C4 -haloalkylthio; R4 =H, CN,...
6217848 Cyanine and indocyanine dye bioconjugates for biomedical applications  
Dye-peptide conjugates useful for diagnostic imaging and therapy are disclosed. The dye-peptide conjugates include several cyanine dyes with a variety of bis- and tetrakis(carboxylic acid)...
6172060 Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses  
Disclosed are nitrosated and/or nitrosylated phosphodiesterase inhibitors having the formula NOn -PDE inhibitor where n is 1 or 2. The invention also provides compositions comprising such...
6156794 Method for treatment of glutamate related disorders  
A method of using a compound of formula (I) wherein R1, R2, R3, X and n have any of the meanings defined in the specification, to antagonize glutamate binding, or to treat glutamate-related...
6114327 Anti-viral compounds  
The present application provides a series of benzimidazole compounds of formula I: ##STR1## which inhibit the growth of picornaviruses, such as rhinoviruses (bovine and human), enteroviruses such...
6048999 N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester synergistic sweetener blends  
This invention provides sweetener blends comprising N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester and another sweetener. The sweetener blends of this invention exhibit...
6048824 2-nitromethylidene/2-cyanimino/2-nitro-imino-pyrrolidines and piperidines, intermediates, and their use as pesticides  
Compounds of formula (I), wherein A is an unsubstituted or substituted aromatic or non-aromatic, monocyclic or bicyclic heterocyclic radical wherein a ring nitrogen atom may have been replaced by...
6008223 Therapeutic compounds  
Compounds of formula I ##STR1## wherein Q1, Q2, Q3, and Q4 have any of the meanings given in the specification, their N-oxides, and their pharmaceutically acceptable salts are nonpeptide...
5965565 Piperidines promote release of growth hormone  
The present invention is directed to certain piperidines, pyrrolidines, and hexahydro-1H-azepines of the general structural formula: ##STR1## wherein B is selected from: ##STR2## and R1, R1a, R2a,...
5861380 Serine protease inhibitors-keto and di-keto containing ring systems  
The present invention relates to certain substituted oxadiazole, thiadiazole and triazole peptoids which are useful as inhibitors of human neutrophil elastase (HNE) for the treatment of...
5854241 Pyrido 3,2,1-I,J! 3,1!benzoxazine derivatives  
Disclosed are pyrido 3,2,1-i,j! 3,1!benzoxazine compounds of the formula (I): ##STR1## wherein z represents a radical having the formula: ##STR2## wherein B represents --CH2 --, --O-- or a direct...
5847115 Azetidinone compound and process for preparation thereof  
There is disclosed an azetidinone compound of the formula I!: ##STR1## wherein Ring B is a benzene ring which may have substituent(s), R1 is a hydroxy-substituted lower alkyl group which may have...
5840732 Imidazopyridine or imidazopyrimidine compounds, their production and use  
This invention provides a new condensed imidazole compound possessing inhibitory activity of adhesion molecule expression.This invention also provides a therapeutic and prophylactic agent for...
5789404 3-substituted 1-arylindole compounds  
3-Substituted 1-arylindole compounds are provided having general formula (I) ##STR1## wherein Ar is an optionally substituted aryl group; X represents a divalent hydrocarbon group, methyleneoxy or...
5760033 1.3 oxa (thia) zines and pest control agents  
A compound represented by the chemical formula 1!: ##STR1## wherein Z is oxygen or sulfur, Y is halogen, optionally substituted alkyl, optionally substituted alkoxycarbonyl, optionally substituted...
5739130 Heterotricyclic derivatives, process for their preparation and pharmaceutical compositions containing them  
Heterotricyclic derivatives of the formula: ##STR1## wherein R1 is hydrogen, lower alkyl, lower alkoxy, lower alkylthio, halogen, nitro, amino or protected amino, R2 is hydroxy, protected hydroxy,...
5686454 Camphorcarbonyl  
The invention is directed to a series of novel compounds of the formula ##STR1## where Y is carbonyl or sulfonyl; R7 and R8 are alkyl, or R7 and R8, together with the carbon to which they are...
5654294 Spiro lactam dual action inhibitors  
Compounds of the formula ##STR1## are disclosed as possessing inhibotory activity against angiotensin converting enzyme (ACE) and neutral endopeptidase (NEP) and thus being useful as...
5646276 Diazepine containing dual action inhibitors  
Compounds of the formula ##STR1## wherein X1 is ##STR2## are disclosed as possessing inhibotory activity against angiotensin converting enzyme (ACE) and neutral endopeptidase (NEP) and thus being...
5641776 Substituted thiosemicarbazone derivatives  
The present invention relates to novel substituted thiosemicarbazone derivatives of formula (I) wherein R1 is lower alkyl, lower alk-2-en-1-yl, lower alk-2-yn-1-yl, or aryl-lower alkyl, R2 is...
5633253 Substituted thiosemicarbazonic acid esters  
The present invention relates to novel substituted thiosemicarbazonic acid esters of formula I ##STR1## wherein R1 is lower alkyl, lower alk-2-en-1-yl, lower alk-2-yn-1-yl, or aryl-lower alkyl, R2...

Matches 1 - 50 out of 307 1 2 3 4 5 6 7 >