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9040550 2,4-pyrimidinediamine compounds and their uses  
The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signaling cascades that lead to the release of chemical mediators, intermediates and methods...
8853397 2,4-pyrimidinediamine compounds and their uses  
The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signaling cascades that lead to the release of chemical mediators, intermediates and methods...
8822685 2,4-pyrimidinediamine compounds and their uses  
The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signaling cascades that lead to the release of chemical mediators, intermediates and methods...
8816074 2′-fluoro-6′-methylene carbocyclic nucleosides and methods of treating viral infections  
The present invention relates to 2′-Fluoro-6′-methylene carbocyclic nucleosides, pharmaceutical compositions containing these nucleosides and their use in the treatment or prophylaxis of a number...
8754078 Compositions and methods for treatment of cancer  
The present invention relates to pyrroloquinolinyl-pyrrolidine-2,5-dione compounds in combination with chemotherapeutic agents. The present invention provides methods of treating a cell...
8691984 Method of storing triallyl isocyanurate  
The present invention provides a method of storing TAIC in which TAIC is prevented from suffering from freezing and solidification during storage thereof in the winter season. In the method of the...
8604193 Processes for preparing HIV reverse transcriptase inhibitors  
Disclosed is a method for preparing HIV reverse transcriptase inhibitors which inhibit replication of HIV in HIV infected cells, and novel intermediate compounds used therein.
8410266 2,4-pyrimidinediamine compounds and their uses  
The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signaling cascades that lead to the release of chemical mediators, intermediates and methods...
8362027 Iontophoretic preparation for treatment of breast cancer and/or mastitis  
The present invention is to provide means to treat breast cancer and/or mastitis by topically administering a non-steroidal antiinflammatory analgetic agent and/or an anticancer agent and allowing...
8318756 Methods for administering DPD inhibitors in combination with 5-FU and 5-FU prodrugs  
Methods for improved administration and dosing of DPD inhibitors in combination with 5-FU and/or 5-FU prodrugs are provided, comprising first administering to a patient in need thereof a DPD...
8148525 2,4-pyrimidinediamine compounds and their uses  
The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signaling cascades that lead to the release of chemical mediators, intermediates and methods...
8034824 Iontophoretic preparation for treatment of breast cancer and/or mastitis  
The present invention is to provide means to treat breast cancer and/or mastitis by topically administering a non-steroidal antiinflammatory analgetic agent and/or an anticancer agent and allowing...
7704971 Uracil reductase inactivators  
Uracil reductase inactivators, notably a 5-substituted uracil or 5,6-dihydro-5-substituted uracil, potentiate 5-flourouracil and find use particularly in the treatment of cancer. The 5-substituent...
7517889 2,6-substituted-4-monosubstitutedamino-pyrimidine as prostaglandin D2 receptor antagonists  
The present invention is directed to a compound of Formula (I) wherein Cy1, Cy2, L1, L2, and R1 are as defined herein, a pharmaceutical composition comprising a pharmaceutically effective amount...
7495006 2′ and 3′-substituted cyclobutyl nucleoside analogs for the treatment of viral infections and abnormal cellular proliferation  
Provided are cyclobutyl nucleosides and methods for their use in treatment of infections including Retroviridae (including HIV), Hepadnaviridae (including HBV), or Flaviviridae (including BVDV and...
7488823 Cyanoguanidines and cyanoamidines as ErbB2 and EGFR inhibitors  
Cyanoguanidine quinazoline and cyanoamidine quinazolamine derivatives that are useful in the treatment of hyperproliferative diseases are disclosed. Methods of treating hyperproliferative diseases...
7285533 Apo-2 ligand  
A novel cytokine, designated Apo-2 ligand, which induces mammalian cell apoptosis is provided. The Apo-2 ligand is believed to be a member of the TNF cytokine family. Compositions including Apo-2...
7119096 Uracil reductase inactivators  
Uracil reductase inactivators, notably a 5-substituted uracil or 5,6-dihydro-5-substituted uracil, potentiate 5-flourouracil and find use particularly in the treatment of cancer. The 5-substituent...
7115544 Plant growth regulators for cotton hervest  
A plant growth regulator for cotton harvest, which contains as an active ingredient, a compound of formula (I): wherein X is CH or nitrogen; Z is halogen; A is oxygen, sulfur, or NH; R1 is...
7109334 Stereoselective methods for the preparation of nucleosides  
A process for producing predominantly cis nucleosides or nucleoside analogues and derivatives of formula (A): wherein R1 is a pyrimidine base or a pharmaceutically acceptable derivative thereof...
7034156 Method for the production of 1-amino-3-phenyluracil derivatives  
The present invention relates to a novel process for preparing known 1-amino-3-phenyluracil derivatives, to novel 1-amino-6-hydroxy-3-phenyldihydro-2,4(1H,3H)pyrimidinedione derivatives of the...
7009050 5-Substituted pyrimidine derivatives of conformationally locked nucleoside analogues  
The embodiments described herein concern 5-substituted pyrimidine derivatives of conformationally locked nucleoside analogues and to the use of these derivatives as anti-viral and anti-cancer...
6794384 Hydroxylation activated drug release  
The present invention concerns prodrugs whose aromatic oxidation, particularly their enzymatic aromatic hydroxylation, results in their activation by the release of a drug moiety. It particularly...
6794506 3-(heteroaryl) alanine derivatives-inhibitors of leukocyte adhesion mediated by VLA-4  
Disclosed are certain 3-(heteroaryl)alanine derivatives which bind VLA-4 and inhibit leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a...
6780821 Substituted phenyl uracils  
The invention relates to new substituted phenyluracils of the general formula (I) in whichn, Q, R1, R2, R3, R4, R5 and X have the meanings given in the description,to process and new intermediates...
6746668 Apo-2 ligand  
A novel cytokine, designated Apo-2 ligand, which induces mammalian cell apoptosis is provided. The Apo-2 ligand is believed to be a member of the TNF cytokine family. Compositions including Apo-2...
6734139 N-aryl-uracile-based herbicides  
The present invention provides herbicidal active compound combinations which comprise, N-aryl-uracils and herbicidally active compounds and/or compounds which improve crop plant compatibility. The...
6713486 Antiviral 2,4-pyrimidinedione derivatives and process for the preparation thereof  
2,4-pyrimidinedione derivatives of formula (I) having high antiviral activity against wild-type and mutant HIV-1 and low toxicity are useful for treating AIDS (I) wherein: R1 is a C6-10 aryl or...
6686155 Method of determining a chemotherapeutic regimen based on glutathione-S-transferase pi expression  
The present invention relates to prognostic methods which are useful in medicine, particularly cancer chemotherapy. The object of the invention to provide a method for assessing GST-pi expression...
6677345 Cyclin dependent kinase inhibitors  
A range is disclosed of pyrimidine derivatives (I) which can act as inhibitors of cyclin dependent kinases (CDK's) and which thereby can provide useful therapeutic compounds for use in treatment...
6649760 Substituted phenyluracils  
Phenyluracils of the general formula (I) in whichQ, R1, R2, R3, R4, R5 and R6 each have one of the meanings given in the description,and processes for their preparation and their use as herbicides.
6624120 Substituted herbicidal phenyluracils  
The invention relates to novel substituted phenyluracils of the general formula (I) in whichm, n, Q, R1, R2, R3, R4, R5, X and Y are each as defined in the description,to processes for their...
6600044 Process for recovery of the desired cis-1,3-oxathiolane nucleosides from their undesired trans-isomers  
A process for the preparation of 1,3-oxathiolane nucleoside analogues in predominantly the cis-form, from mixture of cis-/trans-1,3-oxathiolane nucleosides or their protected derivatives thereof,...
6562759 Substituted phenyl uracils  
The invention relates to novel substituted phenyluracils of the general formula (I) in whichA represents alkanediyl or alkenediyl, each of which has 2 to 5 carbon atoms and each of which is...
6548449 Substituted phenyluracils with herbicidal effect  
The invention relates to novel substituted phenyluraciles of the general formula (I) in whichm, n, Q and R1-7 are each as defined in the description,and to processes for their preparation and to...
6538001 Crystalline modification of 5-fluoro-1-(tetrahydro-2-furyl) uracil and complex compounds based thereon, producing antineoplastic effect  
The invention relates to a novel, heretofore unknown polymorphous modification of 5-fluoro-1-(tetrahydro-2-furyl)uracil (tegafur) having antineoplastic activity. This form is crystalline, and its...
6518425 Method of manufacture of 1,3-oxathiolane nucleosides  
Processes for the preparation of 1,3-oxathiolane nucleosides are provided that include efficient methods for the preparation of the 1,3-oxathiolane ring and subsequent condensation of the...
RE37979 Pyrimidine derivatives and anti-viral agent containing the same as active ingredient thereof  
The disclosure concerns pyrimidine derivatives represented by the following general formulas [I] and [I′] and having antiviral activity, particularly antiretroviral activity such as anti-HIV...
6476224 Method for producing ar(alk)yluraciles, novel corresponding intermediate products and method for producing said intermediate products  
The invention relates to a process for preparing ar(alk)yluracils of the general formula (I) in whichA represents a single bond or represents alkanedlyl,Ar represents optionally substituted...
6455697 Substituted phenyluracils  
The invention relates to novel substituted phenyluracils of the general formula (I) in whichR1, R2, R3, R4, R5 and R6 are each as defined in the description,to processes for their preparation, to...
6448203 Substituted aryluracils  
The invention relates to novel substituted aryluracils of the formula (I): to processes for their preparation and to their use as crop protection agents.
6444616 Substituted p-trifluoromethylphenyluracils  
The invention relates to novel substituted p-trifluoromethylphenyluracils of the general formula (I) in which R1, R2, R3, R4 and R5 are each as defined in the description, to a process for their...
6440676 Diagnostic assay for cancer  
The invention is directed towards gene expression characteristic for cancer, in particular brain cancers such as glioblastoma. Compositions, methods and kits encompassing such therein.
6437126 Substituted phenyluracils  
The invention is directed to a process for the preparation of a substituted phenyluracil of the formula: The process broadly comprises reacting a carbonylphenyluracil of the formula: with an amino...
6417192 Pyrimidinone compounds and pharmaceutical compositions containing them  
A group of novel pyrimidone compounds are inhibitors of the enzyme LDL PLA2 and therefore of use in treating atherosclerosis.
6417141 Substituted aminouracils  
The invention relates to novel aminouracils of the general formula (I) in which,Q, R1, R2, R3, R4, R5, R6 and R7 are each as defined in the description, to their use as herbicides and to novel...
6372691 Method for controlling weeds  
The present invention relates to a method for controlling weeds in corn field which comprises applying a herbicidal composition comprising...
6362337 Substituted phenyluracils  
The invention relates to substituted phenyluracils of the general formula (I) in which the radicals R1 to R5, Q and n are each as defined in the description, and to processes for their preparation...
6344460 Propynyl uracils  
The present invention provides compounds comprising propynyl uracils having the formula wherein R1 is hydrogen, chlorine, bromine, iodine, fluorine, —CN, substituted or unsubstituted linear or...
6313072 Herbicidal 2-aryloxy-or 2-arylthio-6-arylpyrimidines  
The novel compounds of formula I: ##STR1## (A, B, R1, R2, R3, X and m are defined in the specification) show selective herbicidal activity.The new compounds can be prepared according to known...

Matches 1 - 50 out of 327 1 2 3 4 5 6 7 >