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9040550 2,4-pyrimidinediamine compounds and their uses  
The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signaling cascades that lead to the release of chemical mediators, intermediates and methods...
9034850 Gonadotropin releasing hormone receptor antagonist, preparation method thereof and pharmaceutical composition comprising the same  
Disclosed are compounds useful as gonadotrophin-releasing hormone (“GnRH”) receptor antagonist.
8987277 Fungicide  
The invention relates to fungicides and can be used for treating diseases caused by fungi, and also for preventing damage to various materials and agricultural products by fungi. The fungicide is...
8895573 Phenoxy-substituted pyrimidines as opioid receptor modulators  
Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows:...
8853397 2,4-pyrimidinediamine compounds and their uses  
The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signaling cascades that lead to the release of chemical mediators, intermediates and methods...
8841314 2-Thiopyrimidinones  
Myeloperoxidase inhibitors, pharmaceutical compositions containing such inhibitors and the use of such inhibitors to treat, for example, cardiovascular conditions.
8835449 2-thiopyrimidinones  
Myeloperoxidase inhibitors, pharmaceutical compositions containing such inhibitors and the use of such inhibitors to treat, for example, cardiovascular conditions.
8822685 2,4-pyrimidinediamine compounds and their uses  
The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signaling cascades that lead to the release of chemical mediators, intermediates and methods...
8765948 Processes for the preparation of uracil derivatives  
The present invention relates to processes and intermediates for preparing Gonadotropin-Releasing Hormone (GnRH) receptor antagonists of structure (VI); and stereoisomers and pharmaceutically...
8754190 Controlled release from macromolecular conjugates  
The invention relates to conjugates of macromolecular carriers and drugs comprising linkers that release the drug or a prodrug through rate-controlled beta-elimination, and methods of making and...
8748603 Crystalline forms of N-[2-[[(2,3-difluorophenyl)methyl]THIO]-6-{[(1R,2S)-2,3-dihydroxy-1-methylpropyl]oxy}-4-pyrimidinyl]-1-azetidinesulfonamide  
There is provided crystalline forms of N-[2-[[(2,3-difluorophenyl)methyl]thio]-6-{[(1R,2S)-2,3-dihy droxy-1-methylpropyl]oxy}-4-pyrimidinyl]1-azetidinesulfon-am ide anhydrate. Such compounds/forms...
8722883 Pyrimidine sulphonamide derivatives as chemokine receptor modulators  
A compound of formula (I), or a pharmaceutically acceptable salt, solvate or in vivo hydrolysable ester thereof and pharmaceutical compositions comprising these, all for use in the treatment of...
8685991 Anti-infective agents and uses thereof  
This invention relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such...
8609864 Hydroxamic acid derivatives  
The disclosure includes hydroxamic compounds of Formula I: (I) wherein P, Z, and m are defined herein. Also disclosed is a method for treating a neoplastic disease or an immune disease with these...
8569298 Pyridine compounds  
The present invention relates to compounds that inhibit of focal adhesion kinase function, processes for their preparation, pharmaceutical compositions containing them as the active ingredient, to...
8513413 Process for the preparation of nitroorotic acid  
Subject of the present invention is a new improved process for the preparation of nitroorotic acid via nitration of orotic acid.
8501941 Methods for the synthesis of unsymmetrical cycloakyl substituted xanthines  
The present invention provides compounds and pharmaceutical compositions that are selective antagonists of A2B adenosine receptors (ARs). These compounds and compositions are useful as...
8501749 Azaquinazolinediones chymase inhibitors  
Disclosed are small molecule inhibitors of the formula (I), which are useful in treating various diseases and conditions involving chymase.
8492390 Synthesis of locked nucleic acid derivatives  
The invention relates to a novel strategy for the synthesis of Locked Nucleic Acid derivatives, such as α-L-oxy-LNA, amino-LNA, α-L-amino-LNA, thio-LNA, α-L-thio-LNA, seleno-LNA and methylene LNA,...
8450304 4-azetidinyl-1-heteroaryl-cyclohexanol antagonists of CCR2  
The present invention comprises compounds of Formula (I). wherein: R1, R2, R3, and R4 are as defined in the specification. The invention also comprises pharmaceutical compositions comprising the...
8415351 Anti-infective agents and uses thereof  
This invention relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such...
8410266 2,4-pyrimidinediamine compounds and their uses  
The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signaling cascades that lead to the release of chemical mediators, intermediates and methods...
8410123 Pyrimidine sulphonamide derivatives as chemokine receptor modulators  
A compound of formula (I), or a pharmaceutically acceptable salt, solvate or in vivo hydrolysable ester thereof and pharmaceutical compositions comprising these, all for use in the treatment of...
8394809 Phenoxy-substituted pyrimidines as opioid receptor modulators  
Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows:...
8372973 Prokineticin 1 receptor antagonists  
The present invention relates to certain novel compounds of Formula (I): and methods for preparing these compounds, compositions, intermediates and derivatives thereof and for the treatment of...
8362247 Prokineticin 1 receptor antagonists  
The present invention relates to certain novel compounds of Formula (I): and methods for preparing these compounds, compositions, intermediates and derivatives thereof and for the treatment of...
8354421 HIV reverse transcriptase inhibitors  
The invention is related to compounds of Formula (I): or a pharmaceutically acceptable salt, solvate, ester, and/or phosphonate thereof, compositions containing such compounds, and therapeutic...
8269002 Pyrimidine sulphonamide derivatives as chemokine receptor modulators  
A compound of formula (I), or a pharmaceutically acceptable salt, solvate or in vivo hydrolysable ester thereof and pharmaceutical compositions comprising these, all for use in the treatment of...
8236952 Preparations containing amino acids and orotic acid  
The present invention describes compounds produced from an orotic acid molecule and an amino acid molecule. The compounds being in the form of amino acid orotate compounds bound by an amide...
8236951 Thioxanthine derivatives as myeloperoxidase inhibitors  
There is disclosed the use of a compound of formula (Ia) or (Ib) wherein R1, R2, R3, R4, X and Y are as defined in the specification, and pharmaceutically acceptable salts thereof, in the...
8232275 2,2-bis-(hydroxymethyl)cyclopropylidenemethyl-purines and -pyrimidines as antiviral agents  
Compounds which are active against viruses have the following formulas: wherein B is a purine or pyrimidine heterocyclic ring or base. In a preferred embodiment, the purine include 6-aminopurine...
8148525 2,4-pyrimidinediamine compounds and their uses  
The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signaling cascades that lead to the release of chemical mediators, intermediates and methods...
8124417 Method for analyzing nucleobases on a single molecular basis  
A method is herein presented for analyzing nucleobases on a single molecular basis (a single molecule detection), which comprises scanning a molecular tip chemically modified with the...
8119800 Processes for preparing HIV reverse transcriptase inhibitors  
Compounds of Formula (I): can be prepared by a multi-step process from compounds of Formula (II): wherein G is Cl, Br or I.
8088783 MAPK/ERK kinase inhibitors  
Compounds of the substituted 1,3-dialkyl-2,4-dioxo-6-(pyrimidinylamino)-1,2,3,4-tetrahydr opyrimidine-5-hydroxamic acids, show below: wherein the variables are as defined herein, and...
8084458 Synthesis of locked nucleic acid derivatives  
Methods are described for the synthesis of Locked Nucleic Acid (LNA) derivatives using certain nitrogen-containing nucleophiles.
8084615 Antibacterial agents  
Antibacterial compounds of formula I are provided: As well as stereoisomers, pharmaceutically acceptable salts, esters, and prodrugs thereof; pharmaceutical compositions comprising such compounds;...
8080552 Pyrimidyl derivatives as protein kinase inhibitors  
Objects of the present invention are the compounds of formula (I), their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above...
8076302 Pyrimidine nucleoside derivatives and salts thereof  
A novel pyrimidine nucleoside derivative represented by the following formula (1) and a salt thereof, as well as a pharmaceutical composition comprising the same as an active ingredient have...
8030322 Spirocompounds useful as modulators for dopamine D3 receptors  
The present invention relates to compounds of formula (I) or salts thereof wherein A, X, R2, R4 and n are defined herein, processes for their preparation, intermediates used in these processes,...
8026362 Non-nucleoside reverse transcriptase inhibitors  
Compounds of formula I, wherein R1, X1, X2 and A, are as defined herein or pharmaceutically acceptable salts thereof, inhibit HIV-1 reverse transcriptase and afford a method for prevention and...
8017620 Dutpase inhibitors  
Deoxyuridine derivatives of the formula where R1 is H or various substituents;D is —NHCO—, —CONH—, —O—, —C(═O)—, —CH═CH, —C≡C—, —NR5—;R4 is hydrogen or various substituents;R5 is H, C1-C4 alkyl,...
7943626 Substituted 1,3-dialkyl-2,4-dioxo-6-(pyridylamino)-1,2,3,4-tetrahydropyrimidine-5-hydroxamic acid inhibitors of MAPK/ERK kinase  
Compounds of the substituted 1,3-dialkyl-2,4-dioxo-6-(arylamino)-1,2,3,4-tetrahydropyrimi dine-5-hydroxamic acids, show below: wherein the variables are as defined herein, and pharmaceutical...
7893282 7-substituted fused ring tetracycline compounds  
7-substituted fused ring tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-substituted fused ring tetracycline compounds...
7838675 Pyrimidine sulphonamide derivatives as chemokine receptor modulators  
A compound of formula (1), or a pharmaceutically acceptable salt, solvate or in vivo hydrolysable ester thereof and pharmaceutical compositions comprising these, all for use in the treatment of...
7795270 DUTPase inhibitors  
Deoxyuridine derivatives of the formula (I) where R1 is H or various substituents; D is —NHCO—, —CONH—, -0-, —C(═O)—, —CH═CH, —C≡C—, —NR5—; R4 is hydrogen or various substituents; R5 is H, C1-C4...
7741485 Benzenesulphonamide derivatives as herbicides or desiccant/defoliant compounds  
The invention relates to benzenesulphonamide derivatives of formula (I), methods and intermediate products for production thereof and use of said compounds, or means comprising said compounds for...
7727986 Pesticide pyrimidinyloxy substituted phenylamidine derivatives  
The present invention relates to 2,5-disubstituted-4-pyrimidinyl-substituted-phenyl-amidine derivatives of formula (I) in which the substituents are as in the description, notably to...
7696218 Substituted 1,3-dialkyl-2,4-dioxo-6-(arylamino)-1,2,3,4-tetrahydropyrimidine-5-hydroxamic acid inhibitors of MAPK/ERK kinase  
Compounds of the substituted 1,3-dialkyl-2,4-dioxo-6-(arylamino)-1,2,3,4-tetrahydropyrimi dine-5-hydroxamic acids, show below: wherein the variables are as defined herein, and pharmaceutical...
7687500 Substituted oxetanes, method of making, and method of use thereof  
Oxetane-containing nucleosides, particularly non-reducing psiconucleoside oxetanes are described herein. Therapeutic application of these oxetane compounds toward the treatment of nucleoside...