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9023814 Glycomimetic compounds as anti-infectious against pathogens lectins  
The present invention relates to a calixarene-based glycosylated compound (I) having the formula: (I) wherein D is independently selected in the group comprising a —CH2-group, an oxygen atom, a...
8883986 Macrolide polymorphs, compositions comprising such polymorphs, and methods of use and manufacture thereof  
The invention relates to novel forms of compounds displaying broad spectrum antibiotic activity, especially crystalline polymorphic forms and amorphous forms of such compounds, compositions...
8865662 Macrolides and their use  
The invention relates to macrolide compounds of formula (I), the use of said compounds as medicaments, in particular for the treatment or prevention of inflammatory and allergic diseases,...
8859510 Macrocyclic polymorphs, compositions comprising such polymorphs, and methods of use and manufacture thereof  
The invention relates to novel forms of compounds displaying broad spectrum antibiotic activity, especially crystalline polymorphic forms and amorphous forms of such compounds, compositions...
8822705 Pharmaceutical composition for preventing and/or treating bone disease, functional food or health food and pharmaceutical preparation comprising thereof as active ingredient  
The present invention provides a highly safe pharmaceutical composition for preventing and/or treating bone disease, a pharmaceutical preparation comprising thereof, a health food comprising...
8796433 Demulsification compositions, systems and methods for demulsifying and separating aqueous emulsions  
The present invention provides compositions, systems and methods for demulsifying an emulsion including an aqueous phase and an organic phase by adding an effective amount of a composition...
8796230 Ivermectin antagonizes ethanol inhibition in P2X4 receptors  
A method for reducing alcohol consumption in a subject includes a step of identifying a subject exhibiting at least one symptom of alcoholism and then administering a therapeutically effective...
8778914 Bisphosphonate-prodrugs  
The present invention relates to a prodrug, comprising a pharmaceutically and/or diagnostically active compound, and one or more bisphosphonate groups, to a process for producing such a prodrug,...
8778896 Levoisovalerylspiramycin I, II or III, preparations, preparation methods and uses thereof  
Disclosed are levoisovalerylspiramycin I, II or III, preparations, preparing methods and uses thereof. The preparations comprise levoisovalerylspiramycin I, II or III and pharmaceutically...
8618269 Glycorandomization and production of novel novobiocin analogs  
The present invention provides glycorandomized structures and combinatorial methods for rapidly generating a diverse library of glycorandomized structures, comprising incubating one or more...
8518899 Macrocyclic polymorphs, compositions comprising such polymorphs and methods of use and manufacture thereof  
The invention relates to novel forms of compounds displaying broad spectrum antibiotic activity, especially crystalline polymorphic forms and amorphous forms of such compounds, compositions...
8518900 Macrolide synthesis process and solid-state forms  
Described are methods for making macrolides, and, in particular, a method for making optionally substituted 20,23-dipiperidinyl-5-O-mycaminosyl-tylonolide and derivatives thereof, as well as uses...
8507453 Anti-penicillin resistant pneumococci agent and novel 16-membered macrolide derivative  
A novel compound that has antimicrobial activity against penicillin-resistant Streptococcus pneumoniae, and an anti-penicillin resistant pneumococci agent that includes the compound as an active...
8461121 Macrolide synthesis process and solid-state forms  
Described are methods for making macrolides, and, in particular, a method for making optionally substituted 20,23-dipiperidinyl-5-O-mycaminosyl-tylonolide and derivatives thereof, as well as uses...
8445654 Antibiotic macrocycle compounds and methods of manufacture and use thereof  
The invention encompasses an active metabolite of the 18-membered macrocyclic antimicrobial agents, specifically, a metabolite of tiacumicin B and in certain embodiments, R-Tiacumicin B or and its...
8318684 Antibiotics, bispolides A1, A2, and A3 as well as bispolides B1, B2a, B2b and B3 and processes for producing said antibiotics  
Seven novel antibiotic substances can be produced by cultivation of a microbial strain which has been isolated from a soil sample and which is designated as Microbispora sp. A 34030 (deposited...
8268975 Demulsification compositions, systems and methods for demulsifying and separating aqueous emulsions  
The present invention provides compositions, systems and methods for demulsifying an emulsion including an aqueous phase and an organic phase by adding an effective amount of a composition...
8263566 Avermectin B1 and avermectin B1 monosaccharide derivatives having an alkoxymethyl substituent in the 4″-or 4′-position  
What is described are a compound of the formula wherein n is 0 or 1; A-B is —CH═CH— or —CH2—CH2—;R1 is C1-C12-alkyl, C3-C8-cycloalkyl or C2-C12-alkenyl;R2 is for example C1-C12-alkyl,...
8263753 Macrolide synthesis process and solid-state forms  
This invention relates to a method for making macrolides, and, in particular, a method for making optionally substituted 20,23-dipiperidinyl-5-O-mycaminosyl-tylonolide and derivatives thereof, as...
8227429 Macrolide synthesis process and solid-state forms  
This invention relates to a method for making macrolides, and, in particular, a method for making optionally substituted 20,23-dipiperidinyl-5-O-mycaminosyl-tylonolide and derivatives thereof, as...
8133871 Dihydropseudoerythromycin derivatives  
A compound represented by the formula [I] wherein each symbol is as defined in the specification or a pharmacologically acceptable salt thereof, and a pharmaceutical composition containing the...
8053418 Anti-penicillin resistant pneumococci agent and novel 16-membered macrolide derivative  
A novel compound that has antimicrobial activity against penicillin-resistant Streptococcus pneumoniae, and an anti-penicillin resistant pneumococci agent that includes the compound as an active...
8044030 Antibiotic macrocycle compounds and methods of manufacture and use thereof  
The invention encompasses an active metabolite of the 18-membered macrocyclic antimicrobial agents, specifically, a metabolite of tiacumicin B and in certain embodiments, R-Tiacumicin B or and its...
8017589 Avermectin B1 and avermectin B1 monosaccharide derivatives having an alkoxymethyl substituent in the 4″-or 4′-position  
What is described are a compound of the formula wherein n is 0 or 1; A-B is —CH═CH— or —CH2—CH2—;R1 is C1-C12-alkyl, C3-C8-cycloalkyl or C2-C12-alkenyl;R2 is for example C1-C12-alkyl,...
7910558 Bridged macrocyclic compounds and processes for the preparation thereof  
The present invention provides a method for preparing bridged macrocyclic compounds comprising the step of reacting a macrocyclic compound characterized by having at least two nucleophilic...
7879809 Fish production  
This invention is directed to the use of spinosyn or a physiologically acceptable derivative or salt thereof for improved production of fish; controlling ectoparasite infestations in aquaculture...
7863249 Macrolide polymorphs, compositions comprising such polymorphs, and methods of use and manufacture thereof  
The invention relates to novel forms of compounds displaying broad spectrum antibiotic activity, especially crystalline polymorphic forms and amorphous forms of such compounds, compositions...
7816370 Use of epothilones in the treatment of neuronal connectivity defects such as schizophrenia and autism  
The present invention is about the use of at least one epothilone or derivative thereof as an active ingredient for manufacturing a medicament for use in the treatment of disease(s) involving a...
7781411 Derivatives of avermectin, avermectin monosaccharide and avermectin aglycone  
Certain derivatives of avermectin, avermectin monosaccharide and avermectin aglycone, having on the 4″, 4′ or 13 position, respectively, a 6-membered cyclic acetal with a substituent on position...
7737261 Avermectin B1 and avermectin B1 monosaccharide derivatives having an alkoxymethyl substituent in the 4″ -or 4′-position  
Avermectin B1 and avermectin B1 monosaccharide derivative compounds having an alkoxymethyl substituent in the 4″- or 4′-position; a process for preparing and using these compounds and their...
7732416 Avermectins substituted in the 4″-position having pesticidal properties  
What is described are a compound of the formula in whichR1 is C1-C12alkyl, C3-C8cycloalkyl or C2-C12alkenyl;R2 is H, unsubstituted or mono- to pentasubstituted C1-C12alkyl or unsubstituted or...
7709447 Use of spinosyns for wound healing  
A spinosyn or a physiologically acceptable derivative or salt thereof for promoting or accelerating wound healing in humans.
7704961 Avermectins and avermectin monosacharides substituted in the 4′-and 4″ position having pesticidal properties  
Described is a compound of the formula (I) wherein the bond between carbon atoms 22 and 23 is a single or double bond; m is 0 or 1; R1, is C1-C12alkyl, C3-C8cycloalkyl or C2-C12alkenyl; and either...
7687470 Avermectin and avermectin monosaccharide substituted in the 4″- and 4″ position respectively  
Avermectin and avermectin monosaccharaide compounds, derivatives, and compositions thereof are provided as well as processes for preparing such compounds, derivatives, and compositions....
7683161 Selective reduction of spinosyn factors Et-J and Et-L to spinetoram  
Spinetoram is selectively produced in excellent yields by hydrogenating a mixture of 3′-O-ethyl spinosyn J and 3′-O-ethyl spinosyn L in a water miscible organic solvent using hydrogen gas and a...
7678773 Salts of avermectins substituted in the 4″-position and having pesticidal properties  
A compound of formula wherein X− is an anion;n is 1, 2, 3 or 4;R1 is C1-C12alkyl, C3-C8cycloalkyl; or C2-C12alkenyl;R2 is hydrogen, unsubstituted or substituted C1-C12alkyl or C2-C12alkenyl;R3 is...
7678740 Avermectin and avermectin monosaccharide derivatives substituted in the 4″-or 4′-position having pesticidal properties  
What is described are a compound of the formula (I) Wherein U is —N(R2)OR3 or —N+(O−)═C(RE)RZ); n is 0 or 1; X—Y is —CH═CH— or —CH2—CH2—; R1 is C1-C12alkyl, C3-C8cycloalkyl or C2-C12alkenyl; R2...
7655442 Method for stabilizing macrolide compounds  
The present invention provides a method for stabilizing a macrolide compound, and an efficient method for producing the compound. Specifically, it provides a method for stabilizing a macrolide...
7645863 Method of purifying moxidectin through crystallization  
Methods for the purification of the macrolide moxidectin result in higher purity levels than can often otherwise be obtained. The crystalline moxidectin is then used in a wide variety of...
7608595 4″-deoxy-4″-(S)-amido avermectin derivatives  
A compound of formula (I); that has the S-configuration at the 4″-position and wherein the bond between carbon atoms 22 and 23 is a single or a double bond; R1 is C1-C12alkyl, C3-C8cycloalkyl; or...
7585634 Method of predicting risk of lung cancer recurrence, and a composition, kit and microarray for the same  
Provided is a method of predicting risk of lung cancer recurrence in a lung cancer patient or after a patient has lung cancer treatment, the method including: obtaining a biological sample from a...
7579324 Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof  
This invention features a compound of the following formula: T-(-L-C)m, T is a transportophore, L is a bond or a linker having a molecular weight up to 240 dalton, C is a non-antibiotic...
7521429 Avermectin B1 monosaccharide derivatives  
A compound of formula (I) wherein the bond between carbon atoms 22 and 23 may be a single or a double bond; R1 is C1-C12alkyl, C3-C8cycloalkyl, or C2-C12alkenyl; R2 and R3 are, for example,...
7378508 Polymorphic crystalline forms of tiacumicin B  
The invention relates to novel forms of compounds displaying broad spectrum antibiotic activity, especially crystalline polymorphic forms and amorphous forms of such compounds, compositions...
7365174 Azalide and azalactam derivatives and method for producing the same  
Compounds represented by the general formula (1) or pharmaceutically acceptable salts thereof, effective in the prevention and/or treatment of infections with microbes: (1) (a) wherein R1 is...
7358233 Tetronic acid derivative  
The present inventors intended to search for substances that can regulate the expression of a molecular chaperone, GRP78, using the expression of GRP78 as an indicator. As a result, a novel...
7348417 Method of purifying moxidectin through crystallization  
Methods for the purification of the macrolide moxidectin result in higher purity levels than can often otherwise be obtained. The crystalline moxidectin is then used in a wide variety of...
7312200 9-ketospinosyn derivatives  
The present invention relates to derivatives of 9-keto spinosyns, which are substituted by a ═N—(O, NH or NRx)—Ry moiety in the C-9 position, to methods for their manufacture, and to their use for...
7259170 Macrolides containing pharmaceutical compositions  
A pharmaceutical compound comprising a compound of formula I and a pharmaceutically acceptable 2-amino-1,3-propanediol beside one or more pharmaceutically acceptable excipient(s).
7250402 Avermectin derivatives  
A compound represented by the general formula (I) or a salt thereof: wherein represents —CH═CH—, —CH2—CH2— or the like, between R1 and the carbon atom at 4′-position represents a single bond or a...

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