Match Document Document Title
9040669 HLA-restricted, peptide-specific antigen binding proteins  
Antigen binding proteins with T cell receptor-like paratopes, that is, with an antigen binding region specific for an human leukocyte antigen-A2 restricted peptide are disclosed. The antigen...
9035029 CX3CR1-binding polypeptides comprising immunoglobulin single variable domains  
The present invention relates to CX3CR1-binding polypeptides, in particular polypeptides comprising specific immunoglobulin domains. The invention also relates to nucleic acids encoding such...
9034328 Anti-erbB3 antibody  
The present invention relates to an antibody or an antibody fragment thereof which recognizes an extracellular domain of erbB3 and inhibit EGF-like ligand-dependent phosphorylation of erbB3, a DNA...
9028830 Antibodies to CD122  
The invention provides monoclonal antibodies that specifically bind to CD122, which is one component of receptors for IL-2 and IL-15. The monoclonal antibodies have the capacity for substantial...
9029512 Anti-phospho-Akt antibodies  
The present invention relates to antibodies that immunospecifically bind to phospho-Akt and certain p-Akt substrates. The invention encompasses human and humanized forms of the antibodies and...
9017952 Reagents for probing ROCKs activation  
A set of agents is provided for probing/detecting the activation of Rho-associated protein kinase I and II individually encoding their amino acid sequence (SEQ ID NO:1 for ROCKI and SEQ ID NO:2...
9017670 Anti-Tie2 antibodies and uses thereof  
The present invention provides antibodies that bind to Tie2 and methods of using same. According to certain embodiments of the invention, the antibodies are fully human antibodies that bind to...
9018358 DC-STAMP antibodies  
Provided herein are antibodies that specifically bind an epitope of DC-STAMP. Specifically, provided herein are monoclonal antibodies that bind an epitope of DC-STAMP, wherein the epitope...
9017684 Diagnosis and treatment of cancer using anti-EREG antibody  
Methods that entail detection of an epiregulin (EREG) protein for cancer diagnosis are disclosed. In colon cancer, lung adenocarcinoma, pancreatic cancer, stomach cancer, and kidney cancer, the...
9017957 Prostasin partial peptide and anti-prostasin antibody  
An object of the present invention is to provide an antibody that can be stably supplied and can react with prostasin under non-denaturation and denaturation conditions, and an antigen peptide for...
9011856 Antibodies specific for sclerostin and methods for increasing bone mineralization  
Compositions and methods relating to antibodies that specifically bind to TGF-beta binding proteins are provided. These methods and compositions relate to altering bone mineral density by...
9012610 Diagnostic kit for IGFBP-4 proteolytic fragments in a patient sample  
The present invention relates to a method for diagnosing a cardiovascular or cancer disease by detecting IGFBP-4 (Insulin-like Growth Factor Binding Protein-4) fragments in a patient sample....
9011858 Variable region sequences of IL-31 monoclonal antibodies and methods of use  
Novel compositions derived from antigen-binding sites of immunoglobulins having affinity for IL-31 are provided. The compositions exhibit immunological binding properties of antibody molecules...
8999331 Immunobinders directed against sclerostin  
Proteins that bind sclerostin or sclerostin and TNF are described along with there use in composition and methods for treating, preventing, and diagnosing sclerostin related diseases and for...
9000127 Antibodies that bind and block triggering receptor expressed on myeloid cells-1 (TREM-1)  
The invention relates to antibodies that are capable of specifically binding TREM-1 and preventing the activation of TREM-1, a protein expressed on monocytes, macrophages and neutrophils. Such...
8999656 PODXL protein in colorectal cancer  
The present disclosure provides a method for determining whether a mammalian subject having a colorectal cancer belongs to a first or a second group, wherein the prognosis of subjects of the first...
8999651 Screening methods for transfusion related acute lung injury (TRALI)  
The invention relates to the discovery that HNA-3a and HNA-3b are antigens within a polypeptide sequence that is highly similar to the CTL2 amino acid sequence. This invention provides methods and...
8999927 Glial cell line-derived neurotrophic factor (GDNF) compositions and use thereof  
Described herein is the identification of primate-specific glial cell line-derived neurotrophic factor opposite strand (GDNFOS) transcripts and encoded peptides. In particular embodiments,...
8992913 Antagonist antibodies against GDF-8 and uses therefor  
The disclosure provides improved neutralizing anti-GDF-8 antibodies capable of substantially higher levels of expression in host cells compared to previous anti-GDF-8 antibodies. Also provided are...
8993728 Anti-human CLCP1 antibody and use thereof  
The present invention provides novel antibodies that recognize the extracellular domain of a human CLCP1 antigen; nucleic acids encoding the antibodies; vectors carrying the nucleic acids in an...
8993727 Carrier immunoglobulins and uses thereof  
Disclosed is an isolated immunoglobulin. Also disclosed are pharmaceutical compositions and medicaments comprising the immunoglobulin, isolated nucleic acid encoding it, vectors, host cells,...
8986685 Compositions and methods for increasing bone mineralization  
Described herein are pharmaceutical compositions comprising an anti-sclerostin antibody and an inhibitor of bone resorption.
8981061 Receptor TREM (triggering receptor expressed on myeloid cells) and uses thereof  
Novel activating receptors of the lg super-family expressed on human myeloid cells, called TREM(s) (triggering receptor expressed on myeloid cells) are provided. Specifically, two (2) members of...
8981052 JNK inhibitor molecules  
JNK inhibitor molecules are described. In addition, methods for raising antibodies against such JNK inhibitor molecules are disclosed. These antibodies and cells producing these antibodies are...
8981066 Epigenetic mechanisms related to DNA damage and aging  
This invention pertains to markers of cellular senescence. In particular methylation of histone H1 (or isoforms thereof) at residue 172 and/or at residue 180 is a marker of cellular senescence....
8980257 Antibody being capable of binding to transforming growth factor alpha and having growth-suppressing activity on cancers having Ras gene mutation  
It has been found out that among antibodies showing reactivity with wild type TGF-α, antibodies less reactive with G79A-substituted TGF-α have an excellent growth-suppressing effect on cancer...
8980253 Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of cysteinyl-tRNA synthetase  
Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use...
8980272 Antibody targeting osteoclast-associated protein  
The present invention relates to a method of detecting metabolic bone disorders using a gene expressed at a high level in osteoclasts, a method of screening for a compound effective for treatment...
8980260 Monoclonal antibody that binds human notch2 and notch3  
The present invention relates to Notch-binding agents and Notch antagonists and methods of using the agents and/or antagonists for treating diseases such as cancer. The present invention provides...
8974783 Methods of treating pain using an IL-31Ra or OSMR-b antagonist  
Use of antagonists to IL-31Ra and OSMRb are used to treat inflammation and pain by inhibiting, preventing, reducing, minimizing, limiting or minimizing stimulation in neuronal tissues. Such...
8975384 Tag peptide and use thereof  
The present invention provides a tag peptide comprising an amino acid sequence represented by the following formula (I): X1-Tyr-X2-Gly-Gln-X3 (I) (wherein X1, X2 and X3 are the same or different...
8975378 Human anti-human influenza virus antibody  
Provided is a human antibody having a neutralization activity against a human influenza virus. More specifically, provided is a human antibody which recognizes a highly conserved region in a human...
8969529 Methods and compositions based on shiga toxin type 2 protein  
The invention is based on the discovery of the epitope in the Stx2 protein for the 11 E1O antibody. The invention features compositions containing non-full length Stx2 polypeptides that include...
8962808 EGFR-related polypeptides and methods of use  
Described herein are truncated EGF receptor polypeptides, nucleic acids encoding them, and methods of using them to help select a method of treatment for an EGFR-related cancer, to predict...
8961980 Monoclonal antibodies for treatment of cancer  
The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing GT468, including tumor-related diseases such as breast...
8961972 Anti-N3pGlu amyloid beta peptide antibodies and uses thereof  
The present invention provides anti-N3pGlu Aβ antibodies or antigen-binding fragment thereof. In addition, the present invention provides the use of the anti-N3pGlu Aβ antibodies or...
8956869 Peptide inhibiting differentiation of hematopoietic stem cells or hematopoietic precursor cells and use of same  
The present invention provides a novel peptide that can be effectively used to produce or grow tissue-specific stem cells or tissue-specific progenitor cells in vitro. The peptide of the invention...
8951963 Active cores of peptide triazole HIV-1 entry inhibitors  
The invention provides a peptide triazole conjugate and derivatives thereof, and methods of its use. The invention also provides an antibody to the peptide triazole conjugate. The invention...
8952135 S. agalactiae antigens I and II  
The present invention discloses isolated nucleic acid molecules encoding a hyperimmune serum reactive antigen or a fragment thereof as well as hyperimmune serum reactive antigens or fragments...
8951519 Immunotherapy targeting of the shared abnormal conformational state of amyloidogenic peptides/proteins  
The present invention is directed to pharmaceutical agents and compositions useful for the treatment and prevention of amyloid disease in a subject. The invention further relates to isolated...
8945570 Nucleic acid and corresponding protein named 158P1D7 useful in the treatment and detection of bladder and other cancers  
The invention described herein relates to novel nucleic acid sequences and their encoded proteins, referred to as 158P1D7 and variants thereof, and to diagnostic and therapeutic methods and...
8945566 Methods for improving the bioactivity of therapeutic IgE antibodies for the treatment of disease  
The invention provides a method for increasing the bioactivity (e.g. the biosafety and efficacy) of a therapeutic IgE antibody of the invention in the treatment of a patient. Methods of the...
8945548 Anti-IL12Rbeta1 antibodies and their use in treating autoimmune and inflammatory disorders  
The present invention relates to antibodies that specifically bind to IL12Rβ1, the non-signal transducing chain of both the heterodimeric IL12 and IL23 receptors. The invention more specifically...
8940872 Antibody binding specifically to TDP-43 aggregate  
The present invention provides an antibody that specifically binds to an abnormal TDP-43 protein aggregate, an agent comprising the antibody for detecting a TDP-43 proteinopathy lesion, and a...
8940272 Human anti-tau antibodies  
Provided are novel human tau-specific antibodies as well as fragments, derivatives and variants thereof as well as methods related thereto. Assays, kits, and solid supports related to antibodies...
8940874 Neutralizing antibodies against GDF-8 and uses therefor  
The disclosure provides novel antibodies against growth and differentiation factor-8 (GDF-8), in particular human antibodies, and antibody fragments, including those that inhibit GDF-8 activity in...
8927225 Human catechol-O-methyltransferase (COMT) assay  
Disclosed is an assay (method) to quantify the amounts of catecholamine-O-methyltransferase (COMT) protein in samples, such as extracts from cell cultures, body fluids, tissues, and environmental...
8926982 Reagents and methods for detecting influenza virus proteins  
Two universally conserved sequences from influenza type A neuraminidases were identified by large scale sequence analysis then chemically modified and conjugated to carrier proteins to generate...
8920798 Myostatin binding agents, nucleic acids encoding the same, and methods of treatment  
The present invention provides binding agents comprising peptides capable of binding myostatin and inhibiting its activity. In one embodiment the binding agent comprises at least one...
8921523 Humanized anti-beta-amyloid antibodies  
Antigen binding proteins that bind β-amyloid peptide, in particular human β-amyloid peptide; methods of treating diseases or disorders characterized by elevated β-amyloid levels or β-amyloid...