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9029473 Functionalised polymers for binding metal surfaces  
Disclosed are polyvalent macromolecules, compositions comprising the macromolecules, and methods of use. The polyvalent macromolecules have a polymer backbone and pendent groups attached to the...
9018305 Chromatography matrices including novel Staphylococcus aureus protein a based ligands  
The present invention relates to chromatography matrices including ligands based on one or more domains of immunoglobulin-binding proteins such as, Staphylococcus aureus Protein A (SpA), as well...
9012596 Copolymers and methods of use thereof  
Copolymers, such as block copolymers, having at least one block that is a random copolymer of ε-caprolactone and α-carboxy-ε-caprolactone are described. Also described are methods of using such...
9005598 Conjugated proteins and peptides  
Novel compounds of the general formula (I): in which X represents a polymer; Q represents a linking group; W represents an electron-withdrawing moiety or a moiety preparable by reduction of an...
9000090 Polyisoprene condoms  
The present invention relates to processes for making synthetic polyisoprene latex and synthetic polyisoprene condoms. A process for making a compounded synthetic polyisoprene latex suitable for...
8992945 Supramacromolecular polymer complexes providing controlled nitric oxide release for healing wounds  
A bio-adhesive supramacromolecular complex of the general formula: wherein R1 is independently selected from the group consisting of an alkane unsubstituted or substituted with alkoxy groups; R2...
8987377 Poly(amide) polymers for the delivery of oligonucleotides  
The present invention provides poly(amide) polymers, polyconjugates, compositions and methods for the delivery of oligonucleotides for therapeutic purposes.
8975341 Process for attaching a modifying agent to a substrate  
Modifying agents, e.g., a poly(sulfonyl) azide, are attached to a substrate surface, e.g., the surface of a polyolefin particle, by a process comprising the steps of: A. Contacting in an open...
8969473 Compounds and medical devices activated with solvophobic linkers  
The present disclosure relates to compounds and medical devices activated with a solvophobic material functionalized with a first reactive member and methods of making such compounds and devices.
8956638 Biocompatible poly (amic acid) and method of preparation thereof  
A method is provided for the preparation of a poly(amic acid) in which ring opening polymerization is employed to react the monomers ethylenediaminetetraacetic dianhydride and paraphenylenediamine...
8956604 Conjugates comprising an N-oxime bond and associated methods  
Conjugates comprising a N-oxime bond are disclosed. In one embodiment, a suitable conjugate is represented by the following Formula (I): wherein R′ is derived from a compound comprising at least...
8950583 Method to remove heavy metals from a mammal  
A method of supplementing a diet and ameliorating oxidative stress in a mammal includes administering a pharmaceutically effective amount of an active compound having the chemical structure: where...
8952095 Cross-linking agents for hydrogels that contain cleavable peptides and short-chain polymers  
A peptide cross-linking agent in the form of a linear molecule has a molecular mass of 3 to approximately 60 kDa. The peptide cross-linking agents are used for cross-linking functionalized...
8945896 Ligand functionalized polymers  
Ligand functionalized substrates, methods of making ligand functionalized substrates, and methods of using functionalized substrates are disclosed.
8916616 Multi-functional polymeric materials and their uses  
Multifunctional polymers are disclosed having a smart segment and a biodegradable segment. Advantageously, the biodegradable segment includes a hydrophilic segment and a hydrophobic segment....
8916683 Nanostructured physically-associating hydrogels for injectable, responsive, and tough biomaterials  
Described herein are block copolymer conjugates that form double-network hydrogels under appropriate conditions. The conjugates comprise a block of polymer end-group, a block of self-associating...
8911717 Polymalic acid-based multifunctional drug delivery system  
A drug delivery system for delivering a drug payload to a specific tissue or cell type is disclosed. The system includes a polymalic acid molecular scaffold which can be used for attaching a...
8905235 Polymeric reagents comprising a terminal vinylic group and conjugates formed therefrom  
The present invention provides conjugates having a degradable linkage and polymeric reagents useful in preparing such conjugates. Methods of making polymeric reagents and conjugates, as well as...
8906355 Synthetic stereoisomer peptides in the retro-inverso and inverso configuration, and with cyclic and linear structure, their polymer conjugates, their encapsulation in polymer particles, and uses thereof  
This invention discloses ligand-targeted multi-stereoisomer peptide-polymer conjugate compounds comprising a plurality of different synthetic and chemically modified stereoisomer peptides that...
8906343 PAA nanoplatforms containing fluorophores and targeted moieties covalently linked and photosensitizer post-loaded  
A PAA nanoparticle containing a covalently linked fluorescent dye and a post-loaded tetrapyrrolic photosensitizer.
8901017 Formaldehyde-free proteinaceous binder compositions  
Binder compositions are described, where the compositions include a protein, a first crosslinking compound that includes a carbohydrate, and a second crosslinking compound that includes two or...
8889791 Thermoresponsive, biodegradable, elastomeric material  
Provided are novel biocompatible copolymers and compositions comprising the copolymers. The copolymers and degradation products thereof are non-toxic and typically have an LCST between room...
8883188 Modular bioresorbable or biomedical, biologically active supramolecular materials  
The present invention relates to a modular supramolecular bioresorbable or biomedical material comprising (i) a polymer comprising at least two 4H-units and (ii) a biologically active compound....
8883964 Compositions comprising modified collagen and uses therefor  
The invention provides modified collagen and related therapeutic and diagnostic methods.
8853325 Water-soluble polymer alkanals  
The present invention is directed to alkanal derivatives of water-soluble polymers such as poly(ethylene glycol), their corresponding hydrates and acetals, and to methods for preparing and using...
8852747 Coextrusion binders on a renewable/biodegradable basis  
The invention relates to coextrusion binders including renewable and/or biodegradable polymers having good adhesion properties: at least one renewable and/or biodegradable polymer (A) grafted with...
8846110 Polymeric systems for the delivery of anticancer drugs  
The present invention relates to compositions for the treatment of cancerous tissues in warm-blooded animals containing one or two anticancer agents attached to polymeric carriers having monomer...
8846020 Scaffolds formed from polymer-protein conjugates, methods of generating same and uses thereof  
Conjugates are provided herein which comprise a protein attached to at least two polymeric moieties, at least one of which exhibits reverse thermal gelation. The conjugates are suitable for being...
8841382 Hyperbranched polyethers/dendrimers for solubilzation of sparingly soluble active ingredients  
The present invention provides an amphiphile of the formula (I) as described hereinafter. The invention further relates to a process for preparing the amphiphile and to a composition comprising...
8835556 Hydrolytically stable maleimide-terminated polymers  
The present invention is directed to conjugates of hydrolytically stabilized maleimide-functionalized water soluble polymers and to methods for making and utilizing such polymers and their precursors.
8829109 Cleavable modifications to reducible poly(amido ethylenimine)s to enhance nucleotide delivery  
Improved poly(amido ethylenimine) copolymers for gene delivery are disclosed. One illustrative embodiment includes polyethylene glycol (PEG) covalently bonded to a branched...
8821850 Protein-polymer-drug conjugates  
A drug conjugate is provided herein. The conjugate comprises a protein based recognition-molecule (PBRM) and a polymeric carrier substituted with one or more -LD-D, the protein based...
8816001 Genetically encoded initiator for polymer growth from proteins  
This invention pertains to methods for producing homogeneous recombinant proteins that contain polymer initiators at defined sites. The unnatural amino acid, 4-(2′-bromoisobutyramido)phenylalanine...
8815226 Protein-polymer-drug conjugates  
A drug conjugate is provided herein. The conjugate comprises a protein based recognition-molecule (PBRM) and a polymeric carrier substituted with one or more -LD-D, the protein based...
8809452 Damage self-reporting polymer materials having at least two phases  
A synthetic material (22), a sensor comprising the synthetic material (22) and a method for making the synthetic material (22) and the sensor, respectively, as well as the use of this synthetic...
8808679 Auristatin compounds and conjugates thereof  
Auristatin compounds and conjugates thereof are provided herein. The conjugate comprises a protein based recognition-molecule (PBRM) and a polymeric carrier substituted with one or more -LD-D, the...
8809453 Branched polymers  
The present invention is directed to branched reactive water-soluble polymers comprising at least two polymer arms, such as poly(ethylene glycol), attached to a central aliphatic hydrocarbon core...
8791073 Peptide-modified polyurethane compositions and associated methods  
Peptide-modified polyurethanes comprising the reaction product of an isocyanate, a chain extender, and a peptide are provided. Also provided processes for making a peptide-modified polyurethane...
8785371 Drug delivery of temozolomide for systemic based treatment of cancer  
The present invention relates to methods of drug delivery for the treatment of a condition or disease, such as cancer. In one embodiment, the invention provides a method of preparing a...
8765113 Peptide based antimicrobial coating  
A comb-like surfactant polymer for changing the surface properties of biomaterials is described. The surfactant polymer comprises a polymeric backbone of repeating monomeric units having...
8765883 Stabilized polymeric thiol reagents  
Disclosed are water soluble polymeric conjugates comprising the structure POLY-[Y—S—S-A]x, where POLY is a water soluble polymer; Y is a hydrocarbon-based spacer group, x is 1 to 2, S—S is a...
8759444 Conjugated polymers for use in homogeneous and solid state assays  
Disclosed are multichromophores, and methods, articles and compositions employing them. Disclosed are methods, articles and compositions for the detection and analysis of biomolecules in a sample....
8754168 Solubilisation of membrane proteins  
A method is provided for solubilising a membrane protein. The method is applied to cellular material comprising the membrane protein and an associated membrane lipid. A copolymer of styrene and...
8753619 Tissue adhesives and sealants and methods for their use  
Compositions provided by mixing a biotin-containing component and an avidin-containing component are useful as an adhesive or sealant for medical/surgical uses.
8742028 Solid support for Fmoc-solid phase synthesis of peptide acids  
The present invention provides a solid support for Fmoc-solid phase synthesis of peptides. In particular, the solid supports of the invention may be utilized to produce peptide acids.
8729242 Methods for reducing the mitogenicity of lectin compositions  
Methods for reducing the T-cell mitogenicity of lectin compositions are provided. In one aspect this is achieved by chemically modifying mitogenic lectin compositions under optimized conditions....
8710156 Process of preparing functionalized polymers via enzymatic catalysis  
The invention relates to functionalized, telechelic polymers synthesized by enzymatic catalysis and methods, and the functionalization of polymers via Michael addition with a lipase catalyst, and...
8709585 Polymeric structures comprising a siloxane  
Hydroxyl polymer-containing compositions, especially hydroxyl polymer-containing compositions that can be processed into polymeric structures, especially polymeric structures in the form of fibers...
8703293 Coating compositions and coatings for medical devices containing PEGylated hyaluronic acid and a PEGylated non-hyaluronic acid polymer  
Provided herein re a composition and a coating or a device (e.g., absorbable stent) that includes a PEGylated hyaluronic acid and a PEGylated non-hyaluronic acid biocompatible polymer and the...
8703167 Coatings for implantable medical devices for controlled release of a hydrophilic drug and a hydrophobic drug  
Provided herein is a coating that includes cRGD for endothelial cells and methods of making and using the same.