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9017655 Bispecific EGFR/IGFIR binding molecules  
The present invention relates to bispecific molecules comprising an EGFR binding domain and a distinct IGFIR binding domain for use in diagnostic, research and therapeutic applications. The...
8921317 Nano-recombinant fibrinogen for fibrin sealants  
A fibrin-based hemostatic agent suitable for both civilian and military use is disclosed. The hemostatic agent comprises (i) nanoparticles to which a plurality of Knob-A recognition sequences are...
8835501 Pharmaceutical formulations of HDAC inhibitors  
This invention pertains to pharmaceutical compositions comprising certain carbamic acid compounds (e.g., which inhibit HDAC (histone deacetylase) activity) (e.g., PXD-101, N...
8728483 Multivalent fibronectin based scaffold domain proteins  
The present invention relates to multivalent polypeptides comprising at least two fibronectin scaffold domains connected via a polypeptide linker. The invention also relates to multivalent...
8697048 Peptide amphiphile suspension to prevent or reduce tumor formation from administered embryonic stem cells  
The present invention relates to the use of self-assembling peptide amphiphiles to prevent tumor formation by transplanted stem cells. The present invention further relates to the use of...
8609613 Methods of inhibiting type 2 vascular endothelial growth factor receptors using polypeptides  
The present disclosure relates to novel vascular endothelial growth factor receptor (VEGFR)-binding polypeptides and methods for using these polypeptides to inhibit biological activities mediated...
8591885 Carbonic anhydrase inhibitor sustained release intraocular drug delivery systems  
Biocompatible intraocular drug delivery systems include a carbonic anhydrase inhibitor therapeutic agent and a polymeric component in the form of an implant, a microparticle, a plurality of...
8569227 Stabilized fibronectin domain compositions, methods and uses  
A protein scaffold based on a consensus sequence of fibronectin type III (FN3) proteins, such as the tenth FN3 repeat from human fibronectin (human Tenascin), including isolated nucleic acids that...
8524244 Targeted therapeutics based on engineered proteins that bind EGFR  
The present invention relates to single domain proteins that bind to epidermal growth factor receptor (EGFR). The invention also relates to single domain proteins for use in diagnostic, research...
8476010 Propofol formulations with non-reactive container closures  
A sterile pharmaceutical composition for parenteral administration of propofol, said composition comprising propofol, optionally albumin, and less than about 10% by weight solvent for propofol,...
8470332 Targeted therapeutics based on engineered proteins for tyrosine kinases receptors, including IGF-IR  
The present invention provides innovative proteins that bind to insulin-like growth factor-I receptor (IGF-IR), as well as other important proteins. The invention also provides innovative proteins...
8343501 Bispecific EGFR/IGFIR binding molecules  
The present invention relates to bispecific molecules comprising an EGFR binding domain and a distinct IGFIR binding domain for use in diagnostic, research and therapeutic applications. The...
8221765 Multivalent fibronectin based scaffold domain proteins  
The present invention relates to multivalent polypeptides comprising at least two fibronectin scaffold domains connected via a polypeptide linker. The invention also relates to multivalent...
8153591 Protein biomaterials and biocoacervates and methods of making and using thereof  
The present invention relates to protein biocoacervates and biomaterials and the methods of making and using protein biocoacervates and biomaterials. More specifically the present invention...
8097254 Specific binding molecules for scintigraphy, conjugates containing them and therapeutic method for treatment of angiogenesis  
The present invention relates to antibodies with sub-nanomolar affinity specific for a characteristic epitope of the ED-B domain of fibronectin, a marker of angiogenesis. Furthermore, it relates...
7959939 Laminate of cultured human corneal endothelial cells layer and method for manufacturing same  
A laminate comprising a transparent collagen I type sheet and a human corneal endothelial cell culture layer provided on the sheet. An endothelial cell culture layer laminate usable in...
7758895 Methods for purifying insoluble bone gelatin  
The present invention provides methods for purifying insoluble bone gelatin and uses for insoluble bone gelatin. The process for isolating insoluble bone gelatin from bone tissue includes grinding...
7732427 Multifunctional and biologically active matrices from multicomponent polymeric solutions  
The present invention relates to a biologically active functionalized electrospun matrix to permit immobilization and long-term delivery of biologically active agents. In particular the invention...
7727550 Biologically active native biomatrix composition  
The present disclosure relates to a biologically active biomatrix composition. In one embodiment, the biomatrix composition is derived from human amnions. The biomatrix is termed HuBiogel™. The...
7718615 Contortrostatin (CN) and methods for its use in preventing metastasis and other conditions  
Contortrostatin, a homodimeric disintegrin, modulates the adhesion, motility, and invasiveness of integrin expressing tumor cells. When formulated as a pharmaceutically acceptable composition, the...
7691839 Methods and compositions for blocking platelet and cell adhesion, cell migration and inflammation  
The present invention provides compositions of saratin and methods of use thereof. One aspect of the invention is a method of prevention or mitigation of the development of adhesions, keloids and...
7576060 Inhibition of adhesion and migration of an endothelial cell to fibronectin by neutrophil alpha-defensins  
The present invention relates to the inhibition of angiogenesis by neutrophil alpha-defensins. Further, the present invention relates to methods involving the inhibition of endothelial cell...
7479277 Method for reducing intraocular pressure using integrin-linked kinase inhibitor  
Methods for treating increased intraocular pressure by administering agents that interfere with activities of integrin-linked kinase. By interfering with the ability of integrin-linked kinase to...
7399743 Targeted thrombosis  
The invention provided compositions and methods to initiate site-specific thrombosis in tumor vasculature. The present invention also provides methods for using the disclosed compositions and...
7320962 Hemoactive compositions and methods for their manufacture and use  
Dried hemoactive materials comprise both a cross-linked biologically compatible polymer and a non-cross-linked biologically compatible polymer. The cross-linked polymer is selected to form a...
7294617 Method for nonsurgical treatment of the intervertebral disc and kit therefor  
This invention relates to a method and compositions for treating pathological intervertebral discs comprising the step of delivering an agent that causes chemical crosslinking of the native...
7238666 Method of inhibiting fibrosis with a somatostatin agonist  
The present invention relates to a method of inhibiting fibrosis in a patient. The method comprises administering a therapeutically effective amount of a somatostatin, a somatostatin agonist or...
7186684 Hemostatic device containing a protein precipitate  
The present invention is directed to hemostatic devices comprising a substrate, which substrate comprises a precipitate of a protein in an amount effective to provide hemostatic properties to the...
7176184 Treatment for inflammatory bowel disease with a fibronectin polypeptide  
A method for the treatment of inflammatory bowel disease (IBD) is disclosed. The method comprises administration of an antibody, polypeptide or other molecule recognizing VLA-4, a surface molecule...
7163920 Peptide with osteogenic activity  
The present invention provides a composition including an isolated or recombinant peptide component that has osteogenic cell proliferative activity. The peptide, which promotes proliferation of...
7157428 Method for treatment and repair of meniscal injuries  
A method for repair of meniscal injuries comprising induction of meniscal regeneration by introducing a strongly adhesive collagen-polyethylene glycol (PEG) hydrogel to a site of injury.
7148196 Anticancer compounds and methods  
The testing of tumor cells, including human tumors capable of metastases, in assays employing fibronectin-depleted substrates is described. Ex vivo induction of cells, including biopsied human...
7128912 Fibronectin binding protein compositions and methods of use  
Disclosed are antibodies that block the binding of fibronectin protein to fibronectin. Also disclosed are site specifically-mutated and truncated peptide epitopes derived from the fnbA and fnbB...
7125851 Endoprosthesis with long-term stability  
The invention relates to the use of an active substance complex for creating biological parts, in particular organs for living organisms, with the following components which differ from one...
7112320 Solid wound healing formulations containing fibronectin  
A concentrated solution of a wound healing promoter, in particular fibronectin, is used to develop solid wound dressings. The solid wound dressings containing fibronectin are easy to apply, easy...
7109163 Hemostatic compositions and devices  
The present invention includes both sterilized and unsterilized hemostatic compositions that contain a biocompatible liquid having particles of a biocompatible polymer suitable for use in...
7067475 Tek antagonists  
The present invention provides Tek antagonists and methods of inhibiting angiogenesis in a mammal by administering Tek antagonists. The methods are particularly useful in treating diseases or...
6939562 Collagen/polysaccharide bilayer matrix  
Disclosed are bilayer matrices of a polysaccharide such as collagen (COL) and another polysaccharide such as hyaluronic acid (HA) with various COL/HA ratios. Each layer has a porous structure....
6890531 Neuronal growth factor galectin-1  
This invention relates to a remedy for neuropathy, such as nerve injury, nerve degeneration, and hypofunction upon nerve grafting, which contains as the active ingredient galectin-1 having an...
6869927 Keratinocyte growth factor-2 formulations  
The invention is directed to liquid and lyophilized forms of Keratinocyte Growth Factor-2 (KGF-2) and derivatives thereof. This invention further relates to the formulation of KGF-2 for...
6821530 Polymer composite compositions  
The invention relates to methods of treating mixtures containing polymeric materials, e.g., collagen, to form a polymer that intercalates into the polymeric material. The treatment provides...
6818617 EC-3, an inhibitor of α4β1 and α4β7 integrins  
This invention relates to the identification, purification, and characterization of a novel heterodimeric disintegrin, EC-3, from Echis carinatus viper venom. EC-3 inhibits α4 integrins in an...
6737405 Stabilized protein preparation and process for its preparation  
A stabilized protein preparation is described which contains no antithrombin III and is protected against loss of activity during pasteurization by the addition of stabilizers which comprise one...
6685943 Fibronectin binding protein compositions and methods of use  
Disclosed are antibodies that block the binding of fibronectin protein to fibronectin. Also disclosed are site specifically-mutated and truncated peptide epitopes derived from the fnbA and fnbB...
6565842 Crosslinkable polypeptide compositions  
In accordance with the present invention, there are provided rapidly crosslinkable polypeptides which are obtained upon introduction of unsaturated group(s) into the polypeptide via linkage to...
6528483 Method of producing concentrated non-buffered solutions of fibronectin  
Aqueous, non-buffered solutions containing high concentrations of fibronectin and other wound healing promoters are produced, which can then be used to make topical gel and cream formulations with...
6521594 Method and composition for treating thrombosis  
The invention provides cyclic peptides which inhibit platelet aggregation without causing prolonged bleeding time. The invention provides RGD or KGD containing peptides which are cyclized and...
6514734 Polybifunctional reagent having a polymeric backbone and latent reactive moieties and bioactive groups  
A polybifunctional reagent is provided having a polymeric backbone, one or more pendent latent reactive (preferably photoreactive) moieties, and two or more pendent bioactive groups. The reagent...
6475488 Methods of inhibiting angiogenesis and ameliorating cancer by using superfibronectin  
The invention provides a method of inhibiting angiogenesis and treating pathologies with angioproliferative components. The invention provides a method of ameliorating tumor growth and metastasis...
6451326 Cosmetic compositions  
A cosmetic composition including a non naturally-occurring extracellular matrix protein in combination with a cosmetic carrier is described. The protein is preferably of human origin and has not...

Matches 1 - 50 out of 143 1 2 3 >