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9040481 Methods for treating steatotic disease  
Methods for treating fatty liver disease, e.g., hepatic steatosis, using peptide fragments of the C-terminal end of glucagon-like peptide-1 (GLP-1), e.g., GLP-1(28-36).
9034859 Sulfated oxysterol and oxysterol sulfation by hydroxysterol sulfotransferase promote lipid homeostasis and liver proliferation  
Methods and compositions for the prevention and treatment of liver damage or disease in a subject in need thereof are provided. The methods involve providing the sulfated oxysterol...
9034819 Method of lowering cholesterol and triglycerides by administering exendins  
Provided herein are pharmaceutical formulations containing exendins, exendin agonists, or exendin analog agonists that are administered at therapeutic plasma concentration levels over a sustained...
9023789 Amylin analogs and pharmaceutical compositions thereof  
The invention relates to polypeptides comprising an amino acid sequence which is an analog of human amylin, pharmaceutical compositions comprising these polypeptides, and these polypeptides for...
8999940 Analogues of glucose-dependent insulinotropic polypeptide (GIP) modified at N-terminal  
There is provided a novel series of analogues of glucose-dependent insulinotropic polypeptide compounds, pharmaceutical compositions containing said compounds, and the use of said compounds as...
8993518 Compositions and methods for treating antiphospholipid syndrome  
The invention features compositions and methods of using a dimeric inhibitor, e.g., A1-A1, to selectively target β2GPI in β2GPI/antibody complexes. The compositions can be administered to subjects...
8987192 Potent and selective mediators of cholesterol efflux  
The present invention provides a family of non-naturally occurring polypeptides having cholesterol efflux activity that parallels that of full-length apolipoproteins (e.g., Apo AI and Apo E), and...
8969088 Substrate mimicking intercellular lipids in stratum corneum and method of evaluating skin roughening using the same  
A substrate mimicking intercellular lipids in stratum corneum consisting of a substrate and a lipid membrane formed on the substrate, wherein the lipid membrane is formed from ceramide, palmitic...
8936787 Peptides promoting lipid efflux  
Disclosed herein are peptides and peptide analogs with multiple amphipathic α-helical domains that promote lipid efflux from cells via an ABCA1-dependent pathway, as well as peptides that activate...
8889623 Immunostimulatory nanoparticles and related compositions, methods and systems  
Provided herein are immunostimulatory nanolipoprotein particles and related compositions methods and systems.
8865644 Rapamycin formulation using recombinant high-density lipoprotein including apolipoprotein A-I and a mutant thereof  
Provided is a rapamycin formulation using a recombinant high-density lipoprotein including apolipoprotein mutant, the rapamycin formulation in which solubility of rapamycin and medical use, such...
8865155 Lactococcus lactis strains, and bacterial preparations thereof, for the production of bioactive peptides having anti-hypertensive and cholesterol-lowering effects in mammals; nutritional and therapeutic products produced therefrom  
New Lactococcus lactis strains, NRRL B-50571 and NRRL B-50572, and a bacterial preparation containing the same, have the ability to produce bioactive peptides that reduce blood pressure, lower...
8835378 Multi-domain amphipathic helical peptides and methods of their use  
Disclosed herein are peptides or peptide analogs with multiple amphipathic α-helical domains that promote lipid efflux from cells via an ABCA1-dependent pathway. Also provided herein are methods...
8828935 Agent for suppressing elevation of blood triglyceride concentration  
An agent for suppressing elevation of a blood triglyceride concentration, comprising a polyglutamic acid as an active ingredient.
8795669 Stabilized formulations containing anti-PCSK9 antibodies  
The present invention provides pharmaceutical formulations comprising a human antibody that specifically binds to human proprotein convertase subtilisin/kexin type 9 (PCSK9). The formulations may...
8791063 Shortened tetranectin-apolipoprotein A-I fusion protein, a lipid particle containing it, and uses thereof  
Herein is reported a shortened tetranectin-apolipoprotein A-I fusion protein and a lipid particle comprising the shortened tetranectin-apolipoprotein A-I fusion protein as well as uses thereof.
8785128 Genetic diagnosis of hepatic steatosis  
Disclosed are methods of identifying a genetic variant in a person determined to have or be predisposed having a fatty liver by determining whether the person has PNPLA3-I148M. Also disclosed are...
8785382 Lipid therapy  
A method including introducing into a blood stream a delipidated high density lipoprotein (HDL) and a bioactive agent. A composition including a delipidated high density lipoprotein (HDL) and an...
8765663 Methods for increasing adiponectin  
In certain aspects, the present invention provides compositions and methods for increasing adiponectin in a patient in need thereof by administering an antagonist of an ActRIIB signaling pathway....
8735344 Sustained release of APO A-I mimetic peptides and methods of treatment  
A method including advancing a delivery device through a lumen of a blood vessel to a particular region in the blood vessel; and introducing a composition including a sustained-release carrier and...
8673850 PCSK9 inhibitors and methods of use thereof  
A method for identifying a compound for preventing or treating a LDLR-associated disease, a VLDLR-associated disease or an ApoER2-associated disease, said method comprising determining whether: a)...
8653022 Use of ghrelin splice variant for treating hypercholesterolemia and/or high cholesterol and/or high cholesterol complication and/or lipemia and/or lipemia complication and/or coronary heart disease and/or weight management and/or diabetes and/or hyperglycemia  
The present disclosure relates, in one aspect, to use of ghrelin splice variant or an analogue thereof for the preparation of a medicament for one or more of: treatment and/or prevention of...
8648083 Method of treating diabetic hyperlipidemia or hyperlipidemia with carbamoyloxy arylalkanoyl arylpiperazine compounds  
A method of treating diabetic hyperlipidemia or lipidemia with carbamoyloxy arylalkanoyl arylpiperazine compounds including:
8637460 Methods and apparatus for creating particle derivatives of HDL with reduced lipid content  
The present invention is directed to systems, apparatus and methods for creating derivatives of at least one form of HDL without substantially affecting LDL. These derivatives of HDL are particles...
8637450 Methods of promoting fat loss comprising administering an ALK7 inhibitor  
The invention relates to ALK7 soluble receptors and their uses as antagonists of the function of certain ligands such as GDF-8 (Myostatin) and GDF-11. The ALK7 soluble receptor of the invention is...
8618050 Lipid preparation for enhancing mineral absorption  
Disclosed is a dietary ingredient comprising at least one edible lipid which does not inhibit mineral absorption, enhances mineral absorption and intake, particularly a chemically or enzymatically...
8617615 Charged lipoprotein complexes and their uses  
The present disclosure provides charged lipoprotein complexes that include as one component a negatively charged phospholipid that is expected to impart the complexes with improved therapeutic...
8613963 Nutritional supplement  
A nutritional supplement specifically designed to lower cholesterol that addresses multiple mechanisms including hepatic synthesis and release, intestinal absorption of cholesterol, while, at the...
8575091 Amylin analogues and pharmaceutical compositions thereof  
The invention relates to polypeptides comprising an amino acid sequence which is an analogue of human amylin, pharmaceutical compositions comprising these polypeptides, and these polypeptides for...
8574619 Reducing cholesterol levels with combined use of quercetin and statin  
A method of reducing the cholesterol level of a subject by administering to that subject quercetin, vitamin C, vitamin B3, and statin.
8557767 Synthetic apolipoprotein E mimicking polypeptides and methods of use  
The present invention provides novel synthetic apolipoprotein E (ApoE)-mimicking peptides wherein the receptor binding domain of apolipoprotein E is covalently linked to 18A, the well...
8541236 Mutant apolipoprotein A-1 polypeptide with increased resistance to oxidation and reactive carbonyls  
In one aspect, the present invention provides isolated oxidation resistant mutant apoA-I polypeptides comprising an amino acid sequence substantially homologous to SEQ ID NO:4, the mutant apoA-I...
8536117 Oxidant resistant apolipoprotein A-1 and mimetic peptides  
A method for the treatment of cardiovascular disease or disorder in a subject in need thereof, the method comprising the steps of administering an ApoA1 mimetic that is capable of promoting...
8530414 Antibodies to PCSK9 and uses thereof  
The present invention relates to antibodies to proprotein convertase subtilisin/kexin type 9 (PCSK9), or antigen-binding fragments thereof, compositions comprising such PCSK9 antibodies or...
8524253 Bone regeneration device  
This invention is directed to a bone regeneration device including fascia and demineralized bone matrix mixed at a temperature not exceeding about 40° C. and lyophilized into the bone regeneration...
8518892 Methods to treat symptoms of pathophysiology related to body mass  
The expression of a mRNA encoding a putative 76 amino acid, secreted protein (“Enho1”) was found to negatively correlate with fasting triglyceride and cholesterol levels. A recombinant adenovirus...
8476221 Methods and compositions for the treatment of metabolic disorders  
Embodiments described herein are directed to methods for the treatment and control of hyperlipidemia, hypercholesterolemia, dyslipidemia, and other lipid disorders, and in delaying the onset of or...
8460659 Toll-like receptor 3 antagonists for the treatment of metabolic and cardiovascular diseases  
Toll Like Receptor 3 (TLR3) antibody antagonists, polynucleotides encoding TLR3 antibody antagonists or fragments thereof, and methods of making and using the foregoing are disclosed.
8455017 Active substance for improving hyperlipidemia and hypercholesterolemia  
An active substance of medication or health product for hyperlipidemia and hypercholesterolemia comprises djulis, and which can effectively inhibit the absorption of cholesterol, advance the...
8431532 FZD8 extracellular domains and FZD8 extracellular domain fusion molecules and treatments using same  
Methods of treatment using Fzd8 extracellular domains (ECDs), Fzd8 ECD fusion molecules, and/or antibodies that bind Fzd8 are provided. Such methods include, but are not limited to, methods of...
8426363 Method for reducing a level of LDL-cholesterol by an antibody that specifically binds to PCSK9  
The present invention provides antagonizing antibodies, antigen-binding portions thereof, and aptamers that bind to proprotein convertase subtilisin kexin type 9 (PCSK9). Also provided are...
8399014 Physiologically active complex comprising protamine and/or salt therefor and an acidic macromolecular substance, and use thereof  
To provide a method of reducing an intrinsic harsh/astringent taste of protamine and a protamine salt and effectively using a fat absorption suppressive effect of these. A complex is formed by...
8389472 Exendin-4 to treat nonalcoholic steatohepatitis and nonalcoholic fatty liver disease  
The present invention relates generally to the novel use of incretin compounds (ICs) and amylinomimetic compounds to treat, prevent, or ameliorate a variety of metabolic conditions or diseases.
8343916 Use of heat-shock protein 27 for cardiovascular disease prevention and treatment  
A method of reducing cholesterol in a subject is provided. The method may be used to decrease serum cholesterol and/or arterial wall cholesterol. The method comprises administering a...
8343915 Use of heat-shock protein 27 for cardiovascular disease prevention and treatment  
A method of preventing or treating cardiovascular disease is provided. The method comprises administering heat shock protein 27 (HSP27), a co-factor, variant or analogue thereof. The...
8337915 Fenugreek seed extract to lower blood cholesterol  
A method of lowering blood cholesterol in a non-diabetic patient by at least 30% is described. The method involves orally administering for 30 consecutive days a fenugreek seed extract...
8324158 Methods for inhibiting CLC-2 channel with GATX2  
Compositions and methods of using scorpion venom peptide that is a ligand for ClC channels are provided. One aspect provides a pharmaceutical composition containing an amount of GaTx2 effective to...
8318161 Anti-oxidized LDL antibody formulation  
A formulation comprising a therapeutically effective amount of an antibody, optionally, not subjected to prior lyophilization, a buffer maintaining the pH in the range from about 4.5 to about 6.5,...
8318666 Use of leptin to treat metabolic abnormalities associated with lipoatrophy  
Leptin, leptin analogs, and leptin derivatives are used to treat patients with lipoatrophy. Leptin is effective against conditions of lipoatrophy for both genetic and acquired forms of the...
8252845 Pterostilbene as an agonist for the peroxisome proliferator-activated receptor alpha isoform  
Resveratrol has been reported to have hypolipidemic properties. We investigated whether resveratrol and its analogs: pterostilbene, piceatannol and resveratrol trimethyl ether, would activate the...

Matches 1 - 50 out of 298 1 2 3 4 5 6 >