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9034921 |
Diphenylmethane derivatives as SGLT2 inhibitors
A compound with a diphenylmethane moiety having an inhibitory activity against sodium-dependent glucose cotransporter 2 (SGLT2) being present in the intestine and kidney is disclosed. A... |
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8993618 |
Composition for treating influenza A (H1N1) virus and a preparation method therefor
New pharmaceutical compositions extracted from Ferula assa-foetida are confirmed to effectively treat influenza A (H1N1) virus. The extraction method of the new pharmaceutical compositions mainly... |
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8986683 |
Combined use of ribonuclease and artemisinin
The invention discloses a kit which comprises a formulation containing artemisinin or the derivatives thereof, a formulation containing ribonuclease, and a specification. |
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8987323 |
Crystalline form of benzylbenzene SGLT2 inhibitor
Provided are crystalline forms of a compound having an inhibitory effect on sodium-dependent glucose cotransporter SGLT2. The invention also provides pharmaceutical compositions, methods of... |
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8962679 |
Daidzein analogs as treatment for cancer
Provided are compositions for treatment of cancers, including breast cancer, comprising at least one novel daidzein analog, as well as methods of using the same for preventing or treating cancer... |
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8940301 |
Breast tumor treatment with anti-CXCR1 compositions
The present invention provides methods of treating cancer by administering an IL8-CXCR1 pathway inhibitor (e.g., an anti-CXCR1 antibody or Repertaxin) alone or in combination with an additional... |
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8937097 |
Methods for purifying trans-(−)-Δ9-tetrahydrocannabinol and trans-(+)-Δ9-tetrahydrocannabinol
Methods for making trans-(−)-Δ9-tetrahydrocannabinol and trans-(+)-Δ9-tetrahydrocannabinol are disclosed herein. In one embodiment, a trans-(−)-Δ9-tetrahydrocannabinol composition is prepared by... |
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8933116 |
Gamma secretase inhibitors
Disclosed herein are compounds of Formula (I) and pharmaceutically acceptable salts thereof, wherein each of the substituents is given the definition as set forth in the specification and claims.... |
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8927597 |
Compounds useful in the synthesis of halichondrin B analogs
In general, the invention features compounds useful for the synthesis of analogs of halichondrin B, such as eribulin or pharmaceutically acceptable salts thereof, e.g., eribulin mesylate.... |
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8877715 |
Cytotoxic conjugates having neuropeptide Y receptor binding compound
There is provided a series of novel neuropeptide Y-cytotoxic conjugates, compositions comprising the same, and methods relating to their therapeutic use for the treatment of disease or condition... |
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8865761 |
Regulation of cholesterol homeostasis
The invention provides novel compounds of Formulas (I)-(IV), as described herein. Also provided are compositions of these compounds, method of making the compounds, and methods of using the... |
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8858991 |
Delayed release oral pharmaceutical dosage forms comprising MGBG
Disclosed herein are controlled-release oral pharmaceutical dosage forms comprising MGBG, and their application for the improved treatment of diseases with reduced side effects and/or longer time... |
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8841264 |
Compositions
Compositions containing a combination of hydroxytyrosol and resveratrol or liqustilide or (−)-epigallocatechin gallate or honokiol or genistein or Magnolia bark extract or a combination of... |
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8841290 |
Substituted tetrahydronaphthalenes, method for the production thereof, and use thereof as drugs
Disclosed is a tetrahydronapthalene compound having Formula I the variables of which are as described herein, methods of preparing same and their use. |
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8829034 |
Compounds which modulate the CB2 receptor
Compounds of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating... |
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8815941 |
2,3-fluorinated glycosides as neuraminidase inhibitors and their use as anti-virals
Compounds of structural formula (I) useful for the treatment or prophylaxis of viral infection, particularly viral influenza are provided Pharmaceutical preparations thereof and methods for their... |
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8796327 |
Method for inhibiting production of cytokines of T helper cell type II and/or inhibiting production of chemokines using brazilin
A method for inhibiting the production of cytokines of T helper cell type II (Th2 cell) and/or inhibiting the production of chemokines in a mammal is provided, wherein the method comprises... |
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8778988 |
Endoperoxides and methods of photocatalytically synthesizing endoperoxides
A method of making an endoperoxide from a diene and oxygen in the presence of a photocatalyst having an excited state lifetime of at least 100 nanoseconds, the endoperoxide being represented by... |
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8748484 |
Organometallic anti-cancer complexes
An anti-cancer ruthenium complex containing organometallic triruthenium with two maltol ligands is claimed. |
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8633182 |
Indanyloxyphenylcyclopropanecarboxylic acids
The present invention relates to compounds of general formula I, wherein the groups R1, R2, R3, m and n are defined as in claim 1, which have valuable pharmacological properties, in particular... |
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8633026 |
Cytokine induction of selectin ligands on cells
Methods and compositions for treating cells with cytokines are provided herein. |
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8623912 |
Fostriecin derivatives and the pharmaceutical uses thereof
Novel Fostriecin (or FST) derivatives represented by formula (I), the pharmaceutical compositions and preparation methods thereof. The pharmaceutical uses of these compounds, especially the use... |
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8580846 |
Use of equol for ameliorating or preventing neuropsychiatric and neurodegenerative diseases or disorders
The invention is directed to a method of preventing or ameliorating a neuropsychiatric or neurodegenerative disease or disorder in a subject. The method includes administering a composition... |
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8569362 |
Polyketide molecules as anticancer agents
The present invention relates to a polyketide molecule of the following formula (I): or a pharmaceutically acceptable salt thereof, where R1 is a hydrogen atom or a (C1-C7) alkyl group, as well as... |
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8557874 |
Hemostatic material
The present invention relates to hemostatic fabric materials, and to the methods for making and using such materials. In particular, the present invention relates to hemostatic fabric materials... |
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8524214 |
Polyal drug conjugates comprising variable rate-releasing linkers
Polyal-Drug conjugates comprising a variable rate-releasing linker are described along with methods of making such conjugates. Uses for such Polyal-Drug conjugates is also described. |
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8513300 |
Formulations for oral administration of cromolyn sodium
An oral dosage form comprises cromolyn sodium (sodium or disodium cromoglycate), and an acylated amino acid delivery agent. |
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8476311 |
Composition for treating influenza A (H1N1) virus and a preparation method therefor
New pharmaceutical compositions extracted from Ferula assa-foetida are confirmed to effectively treat influenza A (H1N1) virus. The extraction method of the new pharmaceutical compositions mainly... |
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8476314 |
Substance with sedative effect
A substance with sedative effect comprises a therapeutically effective amount of a gamma-pyrone such as comenic acid in a pharmaceutically acceptable carrier. When administered at a daily dosage... |
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8470874 |
Pharmaceutical compositions comprising cannabichromene type compounds
The invention relates to the use of cannabichromene type compounds and derivatives thereof in the treatment of mood disorders. |
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8410165 |
Aldehyde conjugated flavonoid preparations
There is provided a method of conjugating a polymer containing a free aldehyde group with a flavonoid in the presence of an acid catalyst, such that the polymer is conjugated to the C6 or C8... |
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8404740 |
Spirocyclic cyclohexane compounds
Spirocyclic cyclohexane compounds corresponding to formula I In which R1, R2, R3 and R5 through R10 and X have defined meanings, a process for their preparation, pharmaceutical compositions... |
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8399509 |
Glucopyranoside derivatives
Novel compounds of the formula (I), in which X has the meaning indicated in Patent Claim 1, are suitable as antidiabetics. |
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8377930 |
PDE10 inhibitors and related compositions and methods
Compounds that inhibit PDE10 are disclosed that have utility in the treatment of a variety of conditions, including (but not limited to) psychotic, anxiety, movement disorders and/or neurological... |
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8372879 |
4-(heterocycloalkyl) benzene-1,3-diol compounds as tyrosinase inhibitors, process for the preparation thereof and use thereof in human medicine and also in cosmetics
4-(heterocycloalkyl)benzene-1,3-diol compounds are described corresponding to general formula (I) below: Also described, are compositions including the same, processes for preparation thereof and... |
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8367652 |
Methods of treating hypertriglyceridemia
In various embodiments, the present invention provides methods of treating and/or preventing cardiovascular-related disease and, in particular, a method of blood lipid therapy comprising... |
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8367708 |
Phenyl-isoxazol-3-ol derivative
The present invention relates to a compound represented by formula (I), which has a GPR120 agonist action and thus is useful for treatment of diabetes mellitus or hyperlipidemia, or a... |
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8357677 |
Methods of treating hypertriglyceridemia
In various embodiments, the present invention provides methods of treating and/or preventing cardiovascular-related disease and, in particular, a method of blood lipid therapy comprising... |
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8343995 |
Formulations containing clopidogrel and sulfoalkyl ether cyclodextrin and methods of use
The present invention provides compositions containing clopidogrel, present as a free base or a pharmaceutically acceptable salt thereof, and sulfoalkyl ether cyclodextrin (SAE-CD). The... |
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8314140 |
4-hydroxythiobenzamide derivatives of drugs
Derivatives of drugs are provided, said derivatives comprising the H2S-releasing moiety 4-hydroxythiobenzamide that is either covalently linked to the drug or forms a salt with the drug. The... |
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8309118 |
Film forming compositions containing sucralose
Water soluble, gelatin-free dip coatings for substrates comprising a hydrocolloid, such as carrageenan, and sucralose. |
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8288378 |
Phosphoinositide modulation for the treatment of neurodegenerative diseases
The present invention relates to the use of agents that inhibit the toxic effects of amyloid oligomers by increasing intracellular levels of phosphoinositol 4-phosphate (PI(4)P, or “PIP”) and/or... |
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8193239 |
Substituted 1-cyanoethylheterocyclylcarboxamide compounds
The present invention provides compounds of formula (I) in which y, m, n, R1, R2 and Q are as defined in the specification, a process for their preparation, pharmaceutical compositions containing... |
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8187825 |
Thiol detection method
It is an object of the present invention to provide: a novel thiol-detecting reagent, which can be used in vivo and which solves the problem regarding the generation of background fluorescence due... |
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8183213 |
Combination therapy comprising glucose reabsorption inhibitors and retinoid-X receptor modulators
Combination therapy comprising RXR modulators and glucose reabsorption inhibitors useful for the treatment of diabetes and Syndrome X are disclosed. |
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8183233 |
Stable pharmaceutical formulations
Stable pharmaceutical formulations and methods of making same are provided. In a general embodiment, the present disclosure provides a method of making a stable pharmaceutical formulation... |
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8158677 |
Treatment of viral infections by modulation of host cell metabolic pathways
Alterations of certain metabolite concentrations and fluxes that occur in response to viral infection are described. Host cell enzymes in the involved metabolic pathways are selected as targets... |
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8148423 |
Fluorophore compounds
Provided herein are fluorophore compounds including rhodol and rhodamine compounds which can be used as fluorescent labels and/or fluorogenic probes and methods of making same. Provided also... |
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8138163 |
Aldehyde conjugated flavonoid preparations
There is provided a method of conjugating a polymer containing a free aldehyde group with a flavonoid in the presence of an acid catalyst, such that the polymer is conjugated to the C6 or C8... |
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8119695 |
Compounds and methods for treating breast cancer and other diseases
Disclosed are novel compositions and novel methods for the creation of both the novel compounds and known compounds. Also disclosed are methods for use of the novel compounds for treating a... |