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9034917 Sn-2-monoacylglycerols and lipid malabsorption  
The present invention relates generally to the field of lipids and in particular aims at improving lipid absorption, for example under conditions of lipid maldigestion or malabsorption. One...
9018178 Method for the treatment of food, feed and agricultural products with a polyene antifungal compound  
The present invention provides an aqueous antifungal composition comprising a polyene antifungal compound and a thickening agent. The composition can be used in the protection against the...
8980939 Process for the preparation of olopatadine  
A process for the preparation of olopatadine hydrochloride starting from an advanced intermediate.
8980896 Compositions comprising macrocyclic lactone compounds and spirodioxepinoindoles  
The present invention provides formulations which may comprise macrocyclic lactones and at least one spirodioxepinoindole derivative or a spirooxepinoindole derivative for combating parasites in...
8957107 Method of treating scars and β-catenin-mediated disorders using Nefopam compounds  
Methods of treating disorders mediated by β-catenin comprising administration of Nefopam compounds are provided In particular, the treatment of disorders arising from excessive or undesired...
8957056 Migrastatin analogs in the treatment of cancer  
In one aspect, the present invention provides a method for treating colon and/or ovarian cancer in a subject comprising administering to a subject in need thereof a compound of general formula...
8945597 Botanical insecticides  
The invention generally relates to environmental friendly pesticide compounds, formulations, methods of preparation and application and utilities thereof. More particularly, the invention relates...
8940787 Use of artemisinin for treating tumors induced by oncogenic viruses and for treating viral infections  
In certain aspects, the invention relates to methods of treating proliferative cervical disorders (such as cervical cancer and cervical dysplasia) and treating virus infection by administering...
8940788 Anti-angiogenic composition containing macrolactin A and a derivative thereof as active ingredients  
The present invention relates to an anti-angiogenic composition containing macrolactin compounds such as macrolactin A, 7-O-malonyl macrolactin A, and 7-O-succinyl macrolactin A as active...
8937056 Multikinase inhibitors for use in the treatment of cancer  
The present invention provides compounds, pharmaceutical compositions and methods for the treatment of specific cancers. Such compositions may generally comprise a compound of formula (I): wherein...
8937096 Use of benzo-fused heterocyle sulfamide derivatives for the treatment of mania and bipolar disorder  
The present invention is a method for the treatment of mania and/or bipolar disorder comprising administering to a subject in need thereof a therapeutically effective amount of one or more novel...
8927596 Antischistosomal agent  
An object of the present invention is to provide a novel antischistosomal agent, and more specifically, to provide a novel drug capable of inhibiting a growth of schistosomes in vivo to prevent...
8927594 Compounds from soft coral, method of preparation and pharmaceutical uses thereof  
The invention relates to compounds from the soft coral and the generation thereof. The invention also relates to the uses of the compounds from the soft coral in inhibiting inducible nitric oxide...
8927595 Topical avermectin formulations and methods for elimination and prophylaxis of susceptible and treatment resistant strains of head lice  
An avermectin-based topical formulation is disclosed which is useful for prevention and treatment of head lice (Pediculus humanus capitis). This topical formulation may be formulated as a...
8921412 C-aryl ansa SGLT2 inhibitors  
Disclosed is a novel C-aryl ansa compound having an inhibitory activity against sodium-dependent glucose cotransporter 2 (SGLT2) being present in the intestine and kidney, and a pharmaceutical...
8921320 Targeted osmotic lysis of cancer cells  
A targeted osmotic lysis (TOL) of tumor cells that over-express voltage-gated sodium channels (VGSCs) has been developed that uses a combined therapy of a drug that blocks sodium,...
8901167 Product and process for inhibition of biofilm development  
Disclosed are compositions and methods for the inhibition of biofilm formation or reduction of existing or developing biofilms in a patient. These methods also inhibit the aggregation of bacteria...
8901163 Method of treating hyperesthesia, paresthesia, dolor, and pruritus caused by insect stings or noxious weeds or plants using avermectin compound  
A method of treating hyperesthesia, paresthesia, dolor, and pruritus caused by an insect or arthropod sting or bite, or a skin contact with a noxious weed or plant is disclosed. The method...
8901164 Amphipathic and other double-sided alpha-helix mimetics based on a 1,2-diphenylacetylene scaffold  
Small-molecule scaffolds based on 1,2-diphenylacetylene that accurately replicate the spatial and angular projections of several side chains on both faces of an α-helix, specifically the i and i+7...
8883765 Anti-cytomegalovirus activity of artemisinin-derived dimers  
Artemisinin-derived monomers and artemisinin dimers are shown to exhibit in-vitro anti-cytomegalovirus (CMV) activity. Artemisinin dimers effectively inhibited CMV replication in human foreskin...
8877715 Cytotoxic conjugates having neuropeptide Y receptor binding compound  
There is provided a series of novel neuropeptide Y-cytotoxic conjugates, compositions comprising the same, and methods relating to their therapeutic use for the treatment of disease or condition...
8865761 Regulation of cholesterol homeostasis  
The invention provides novel compounds of Formulas (I)-(IV), as described herein. Also provided are compositions of these compounds, method of making the compounds, and methods of using the...
8853263 Co-therapy for the treatment of epilepsy and related disorders  
The present invention is directed to co-therapy for the treatment of epilepsy and related disorders comprising administering to a subject in need thereof, co-therapy with a therapeutically...
8846750 Pharmaceutical and food compositions for preventing or treating diabetes or obesity  
The present invention relates to pharmaceutical and food compositions for preventing or treating diabetes or obesity, and more particularly to pharmaceutical compositions and functional foods for...
8841341 Pharmaceutical composition effective against biofilms  
The invention provides a compound termed Carolacton having the structure and derivatives thereof for medical use against biofilm formation by bacteria.
8835462 Macrocyclic picolinamides as fungicides  
The disclosure relates to macrocyclic picolinamides of Formula I and their use as fungicides.
8822528 Monensin derivatives for the treatment and prevention of protozoal infections  
This invention relates to novel polyether ionophores, formulations comprising same, and to methods of making and using these compounds and formulations for the treatment and/or prevention of...
8815938 Double compartment skincare products comprising avermectin/milbemycin compounds  
Double compartment skincare products confine a first compartment containing an anhydrous composition including an active ingredient, and a second compartment, wherein the active ingredient is...
8815844 Mitochondrial activity inhibitors of cancer-initiating cells and use thereof  
The present invention relates to the compounds useful in the prevention and/or treatment of tumors. More specifically the present invention relates to inhibitors of the activity of the electron...
8802125 Controlled-delivery system of pharmacologically active substances, preparation process and medical use thereof  
The invention concerns a system for biocompatible drug release comprising: (i) a polymer matrix; (ii) an inorganic component located inside said matrix and characterized by a lamellar structure...
8791154 High concentration olopatadine ophthalmic composition  
The present invention is an ophthalmic composition containing a relatively high concentration of olopatadine. The composition is typically an ophthalmic aqueous solution containing relatively high...
8791153 Topical avermectin formulations and methods for elimination and prophylaxis of susceptible and treatment-resistant strains of head lice  
An avermectin-based topical formulation is disclosed which is useful for prevention and treatment of head lice (Pediculus humanus capitis). This topical formulation may be formulated as a...
8785479 Macrocyclic picolinamides as fungicides  
The invention relates to macrocyclic picolinamides of Formula I and their use as fungicides.
8785483 Methods for treating COPD  
Embodiments of the invention include methods and compositions involving aldose reductase inhibitors for treating COPD.
8765160 Methods for control of soil-dwelling pests and/or soil-borne diseases  
A method for the control of soil-dwelling pests and/or soil-borne diseases comprising treating a plant propagation material with an effective amount of the pesticidal composition and/or applying...
8741889 Method of treating non-small cell lung cancer and colon cancer with gamma-secretase inhibitor  
The present invention provides a method for treating a patient having cancer comprising administering to the patient a therapeutically effective amount of compound (1), or a pharmaceutically...
8741948 Oral antimicrobial pharmaceutical compositions  
The present invention relates to oral pharmaceutical compositions with controlled and/or programmed release containing at least one active ingredient having antimicrobial and/or anti-infectious...
8729120 Adjunctive therapy for depression  
This invention is directed to a method of treating depression in a subject, comprising the step of administering a therapeutically effective amount of a conventional antidepressant and, in...
8722700 CCI-779 formulations for parenteral administration  
This invention provides CCI-779 cosolvent concentrates which are useful in preparing a parenteral formulation of rapamycin 42-ester with 3-hydroxy-2-(hydroxymethyl)-2-methylpropionic acid...
8703812 Protein synthesis required for long-term memory is induced by PKC activation on days preceding associative learning  
The present invention provides methods of contacting a protein kinase C (PKC) activator with a PKC activator in a manner sufficient to stimulate the synthesis of proteins sufficient to consolidate...
8691808 Antiviral compounds and their methods of use  
The present disclosure provides compounds having affinity for the M2 proton channel, useful for the treatment of viral infections such as influenza, which are of the Formula (I): wherein R1, R2,...
8691867 Use of benzo-fused heterocycle sulfamide derivatives for the treatment of substance abuse and addiction  
The present invention is a method for the treatment of alcohol abuse and/or addiction comprising administering to a subject in need thereof a therapeutically effective amount of one or more novel...
8680111 Macrocyclic derivatives for the treatment of diseases  
The invention relates to compounds of formula (Φ) as further defined herein and to the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and...
8673949 Use of epothilone D in treating Tau-associated diseases including Alzheimer's disease  
Methods of treating Tau-associated diseases, preferably tauopathies, are described using epothilone D that exhibit good brain penetration, long half-life, and high selective retention in brain,...
8673890 2,3-dihydro-1H-isoindol-1-imine derivatives useful as thrombin PAR-1 receptor antagonist  
The present invention is directed to novel 2,3-dihydro-1H-isoindol-1-imine derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions...
8642613 Treatment for leukemia and idiopathic aplastic anemia  
A process for treating a patient with leukemia or an aplastic anemia having cells with inclusions that stain with anti-E. canis antibodies or antibodies to other Ehrlichia or Anaplasma is...
8628794 Palatable ductile chewable veterinary composition  
The present invention is directed to palatable ductile chewable veterinary composition for oral administration. The composition is capable of killing endo-parasites and ecto-parasites and/or can...
8623908 Use of tellurium compounds for inhibition of interleukin-converting enzyme  
Use of tellurium-containing compounds for treating conditions in which inhibition of caspase-1/interleuFkin-1β enzyme (ICE) is beneficial is disclosed.
8613929 Methods and compositions for targeting agents into and across the blood-brain barrier and other endothelial cell microvascular barriers  
The present invention relates to nucleic acids and polypeptides encoded thereby, whose expression is modulated in brain microvascular endothelial cells undergoing early dynamic...
8609716 Chondropsin-class antitumor V-ATPase inhibitor compounds, compositions and methods of use thereof  
A composition comprising a substantially purified compound of the formula: in combination with at least one additional therapeutic agent, and methods of preventing or treating cancer and a...