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9023837 Androgen induced oxidative stress inhibitors  
Described herein are pharmaceutical compositions and medicaments, and methods of using such pharmaceutical compositions and medicaments in the treatment of cancer.
8993619 Cyclic bridgehead ether DGAT1 inhibitors  
The invention relates to compounds of formula (I): useful for treating disorders mediated by acyl coA-diacylglycerol acyl transferase 1 (DGAT1), e.g. metabolic disorders. The invention also...
8987258 Chromenone analogs as sirtuin modulators  
The present invention relates to novel chromenone analog sirtuin modulator compounds of Formula (I): or pharmaceutically acceptable salts thereof, corresponding pharmaceutical compositions and...
8975263 Phenylxanthene derivatives  
The present invention relates to a compound or a pharmacologically acceptable salt thereof having an excellent glucose lowering effect. A compound represented by the following general formula (I)...
8969352 Substituted 2-azabicycles and their use as orexin receptor modulators  
The present invention is directed to compounds of Formula I: wherein X is N or CR1; Y is N or CR2; R1 is H, alkoxy, halo, triazolyl, pyrimidinyl, oxazolyl, isoxazole, oxadiazolyl, or pyrazolyl; R2...
8969345 Dibenzooxepin derivative  
A dibenzoxepin derivative represented by the following general formula (I) wherein Y is a hydrogen atom and the like, RA is a hydrogen atom and the like, X is the formula (b3) wherein RB is a...
8962660 Oxabicyclo [2.2.2] acid GPR120 modulators  
The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are...
8952003 Sterol derivative  
The present invention provides a sterol derivative or a pharmaceutically acceptable salt thereof having an activity to promote proliferation of neural stem cells. Namely, the present invention...
8937055 Heterocyclic ring compound having muscle cell or adipocyte differentiation regulating action  
The present invention provides a compound having a muscle cell or adipocyte differentiation regulating action, useful for the prophylaxis or treatment of diseases such as diabetes, obesity,...
8927544 Benzofuran-2-sulfonamides derivatives as chemokine receptor modulators  
The present invention relates to benzofuran-2-sulfonamide derivatives with the following formula: or pharmaceutically acceptable salts thereof. The derivatives are useful as modulators of...
8895585 Nicotinamide derivative or salt thereof  
An object of the present invention is to provide to a compound and a pharmaceutical composition, which have excellent Syk-inhibitory activity. The present invention provides a nicotinamide...
8889710 Parasiticidal dihydroisoxazole compounds  
Provided are dihydroisoxazole compounds I useful for controlling parasites both in animals and agriculture. Further provided are methods for controlling parasite infestations of an animal by...
8853125 Pyrazole compounds for controlling invertebrate pests  
The present invention relates to a method for controlling invertebrate pests which method comprises treating the pests, their food supply, their habitat or their breeding ground or a plant, seed,...
8829026 Sulfamoyl benzoic acid heterobicyclic derivatives as TRPM8 antagonists  
The present invention relates to sulfamoyl benzoic acid heterobicyclic derivatives of the formula (I) or a pharmaceutically acceptable salt thereof or a prodrug thereof, processes for their...
8815915 Benzofuran-2-sulfonamides pyridine derivatives as chemokine receptor modulators  
The present invention relates to novel benzofuran-2-sulfonamide pyridine derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as...
8815864 Indanyloxydihydrobenzofuranylacetic acids  
The present invention relates to compounds of general formula I, wherein the group (Het)Ar is defined as in claim 1, which have valuable pharmacological properties, in particular bind to the GPR40...
8809327 Sulfonamides as TRPM8 modulators  
Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows:...
8809374 Spot-on pesticide composition  
A spot-on pesticide composition for animals, specifically mammals, including dogs and cats, which composition comprises a combination of active components, including fipronil and a pyrethroid, and...
8809371 ***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
Nicotinamide derivative or salt thereof
 
An object of the present invention is to provide to a compound and a pharmaceutical composition, which have excellent Syk-inhibitory activity. The present invention provides a nicotinamide...
8809375 Spot-on pesticide composition  
A spot-on pesticide composition for animals, specifically mammals, including dogs and cats, which composition comprises a combination of active components, including fipronil and a pyrethroid, and...
8809376 Indanyloxydihydrobenzofuranylacetic acids  
The present invention relates to compounds of general formula I, wherein the groups R1, R2 and m are defined as in claim 1, which have valuable pharmacological properties, in particular bind to...
8796271 Heteroaryls and uses thereof  
This invention provides compounds of formula IA-a or IB-a and subsets thereof: wherein Z, HY, R1, R2, G1, W, n, and A and subsets thereof are as described in the specification. The compounds are...
8796275 Anti-malarial compounds  
The present invention provides tricyclic compounds, arylamide compounds, and other compounds, and compositions comprising the same, for treating malaria, and methods of treating malaria comprising...
8785445 7-phenoxychroman carboxylic acid derivatives  
Compounds of Formula I: (I) in which A, A1, R1, R7a, R7b, R8 and R10 have the meanings given in the specification, are DP2 receptor inhibitors useful in the treatment of useful in the treatment...
8772320 ***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
Nicotinamide derivative or salt thereof
 
An object of the present invention is to provide to a compound and a pharmaceutical composition, which have excellent Syk-inhibitory activity. The present invention provides a nicotinamide...
8765791 Method of treating cancer using a neuropeptide Y 5R (NP Y5R) antagonist  
The present invention relates to methods for treating cancer by administering a therapeutically effective amount of compound of formula (I), such as selective NPY5R antagonist MK-0557...
8729068 Tetrahydrobenzothiophene compound  
The purpose is to provide a compound which has an intestinal phosphate transporter (NPT-IIb) inhibitory action and is useful as an active ingredient of an agent for treating and/or preventing...
8715710 Semi-solid delivery vehicle and pharmaceutical compositions for delivery of granisetron  
A semi-solid delivery vehicle contains a polyorthoester and an excipient, and a semi-solid pharmaceutical composition contains an active agent and the delivery vehicle. The pharmaceutical...
8691780 Txr1 and enhanced taxane sensitivity based on the modulation of a pathway mediated thereby  
Methods and compositions for enhancing taxane sensitivity are provided. Aspects of the subject methods include administering to a subject a txr1 pathway modulatory agent in conjunction with a...
8648097 Pyridylaminoacetic acid compound  
The present invention provides a novel pyridylaminoacetic acid compound represented by the following formula (1): (wherein R1, R2, R3, Y and Z are as defined in the description and claims), or a...
8642585 Indanyloxydihydrobenzofuranylacetic acids  
The present invention relates to compounds of general formula I, wherein the groups R1, R2 and m are defined as in claim 1, which have valuable pharmacological properties, in particular bind to...
8642643 CXCR2 antagonists  
The invention relates to compounds of the formula I in which R1, R2, A, B, X and Y have the meanings indicated in the claims, and/or a pharmaceutically acceptable salt and/or a prodrug thereof....
8604061 2-aminooxazolines as TAAR1 ligands  
The invention relates to compounds of formula I wherein X, Y, R1, R2, and n are as defined hereinor to a pharmaceutically suitable acid addition salt thereof. The invention also relates to...
8575198 In-process control for the manufacture of glatiramer acetate  
The present disclosure provides methods for manufacturing or producing glatiramer acetate having a Mp of 5000-9000 Da. These methods include: polymerizing N-carboxy anhydrides of L-alanine,...
8546403 Compounds that modulate intracellular calcium  
Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of...
8513280 Use of epothilones in the treatment of neuronal connectivity defects such as schizophrenia and autism  
The present invention is about the use of at least one epothilone or derivative thereof as an active ingredient for manufacturing a medicament for use in the treatment of disease(s) involving a...
8476313 Heteroaryl-containing isoflavones as aromatase inhibitors  
Compounds and methods useful for treating and prevention of cancer, particularly hormone-dependent breast cancer. Provided are compounds of formula I: wherein X is selected from O, N, S, SO, SO2,...
8466175 Form of S-omeprazole  
The present invention relates to a novel form of the (−)-enantiomer of 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methyl]su lfinyl]-1H-benzimidazole, i.e. S-omeprazole. More specifically,...
8466166 Benzimidazole derivatives as selective acid pump inhibitors  
This invention relates to compounds of the formula (I): or a pharmaceutically acceptable salt thereof, wherein: R1, R2, R3, R4, A and E are each as described herein or a pharmaceutically...
8377963 Insulin-regulated aminopeptidase (IRAP) inhibitors and uses thereof  
The present invention relates to inhibitors of insulin-regulated aminopeptidase (IRAP) and methods for inhibiting same, as well as compositions comprising said inhibitors. In particular, the...
8372866 2-aryl and 2-heteroaryl 4H-1-benzopyran-4-one-6-amidino derivatives, new pharmacological agents for the treatment of arthritis, cancer and related pain  
2-aryl and 2-heteroaryl 4h-1-benzopyran-4-one-6-amidino derivatives formula (I) useful as pharmacological agents for the treatment of arthritis, cancer and related pain.
8354410 Compounds for the treatment of hepatitis C  
The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and...
8329686 Isatin analogues and uses therefor  
Novel isatin analogues, including isatin analogues comprising Michael Acceptors (IMAs) are disclosed. Further disclosed are methods of synthesis of the isatin analogues, and uses of the analogues,...
8324247 Method for treating pulmonary arterial hypertension  
Pulmonary arterial hypertension in a mammal can be prevented or treated using combined 5-HT2A and 5-HT2B receptor antagonist. The antagonists can be present in a single compound or in two separate...
8318775 N-(heteroaryl)-1-heteroarylalkyl-1H-indole-2-carboxamide derivatives, preparation and therapeutic use thereof  
The invention concerns compounds of general formula (I), wherein n, X1, X2, X3, X4, Y and W are as defined herein. The invention also concerns a method for preparing said compounds and their...
8309608 Use of eNOS transcription enhancers in the cell therapy of ischemic heart diseases  
The present invention relates to the use of compounds which enhance the transcription of endothelial nitric oxide synthase (eNOS) for treating stem and progenitor cells in the cell therapy of...
8278290 Tubulin polymerisation inhibitors  
The present invention relates to compounds of general formula (I) as tublin polymerization inhibitors and methods for preparing such compounds.
8278332 Photostabilization of retinoids with alkoxycrylene compounds  
The photostabilizing electronic excited state energy—particularly singlet state energy from retinoid compounds—has been found to be readily transferred to (accepted by) α-cyanodiphenylacrylate...
8263051 Photostabilization of resveratrol with alkoxycrylene compounds  
The photostabilizing electronic excited state energy—particularly singlet state energy from resveratrol compounds—has been found to be readily transferred to (accepted by) α-cyanodiphenylacrylate...
8252305 Methods of treating emesis utilizing semi-solid delivery pharmaceutical compositions comprising granisetron  
A semi-solid delivery vehicle contains a polyorthoester and an excipient, and a semi-solid pharmaceutical composition contains an active agent and the delivery vehicle. The pharmaceutical...