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9040457 Phenylamidines having a high fungicidal activity and use thereof  
New phenylamidines are described, having general formula (I): and their use for the control of phytopathogenic fungi.
9023850 Nematocidal sulfonamides  
Disclosed are compounds of Formula 1, N-oxides, and salts thereof, wherein Z is O or S;A1, A2, A3 and A4 are independently N or CR1, provided that only one of A1, A2, A3 and A4 is N; andR1, R2, R3...
9018207 Method of treatment or prophylaxis  
The present invention is directed to methods and agents that are useful in the prevention and amelioration of signs and symptoms associated with neuropathic conditions. More particularly, the...
8999984 Macrophage migration inhibitory factor antagonists and methods of using same  
Methods of inhibiting one or more biological activities of Macrophage migration inhibitory factor (MIF) polypeptides are provided using an MIF inhibitory compound. The methods include therapeutic...
9000031 Thioxanthone-based autophagy inhibitor therapies to treat cancer  
The present specification provides compositions comprising a thioxanthone-based autophagy inhibitor and/or a cancer therapeutic autophagy inducing compound, pharmaceutical kits comprising these...
8993509 Method for treatment of cachexia by administering inhibitors of adipose triglyceride lipase expression or activity  
The present invention relates to agents, and methods for identifying compounds, which agents and compounds are effective in the treatment, and more particularly, that inhibit cachexia, and its...
8993569 Diarylpyridazinone derivatives, preparation thereof, and use thereof for the treatment of humans  
The present invention relates to diarylpyridazinone derivatives that block the potassium Kv channels (specifically the Kv1.5, Kv4.3, and Kv11.1 channels) and to the use thereof for the treatment...
8993595 Macrocyclic serine protease inhibitors  
Provided herein are macrocyclic serine protease inhibitor compounds, for example, of Formula Ia or Ib, pharmaceutical compositions comprising the compounds, and processes of preparation thereof....
8987266 EGFR mutations  
The present invention relates to mutations in Epidermal Growth Factor Receptor (EGFR) and methods of detecting such mutations as well as prognostic methods method for identifying a tumors that are...
8980894 Use of PDE III inhibitors for the treatment of asymptomatic (occult) heart failure  
The invention relates to the use of a phosphodiesterase type III (PDE III) inhibitor or Ca2+-sensitizing agent or a pharmaceutically acceptable derivative thereof for the preparation of a...
8980884 Methods for treating Alzheimer's disease  
Pharmaceutical compositions for treating Alzheimer's disease are disclosed. The pharmaceutical compositions include a compound having the general formula: and a pharmaceutically acceptable...
8969347 Compounds and methods for treating inflammatory and fibrotic disorders  
Disclosed are compounds and methods for treating inflammatory and fibrotic disorders, including methods of modulating a stress activated protein kinase (SAPK) system with an active compound,...
8969346 Amino-pyridazine skeletal muscle modulators  
Provided are compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, X and m are as defined herein. Also provided is a pharmaceutically...
8969348 Chymase inhibitors  
Disclosed are small molecule inhibitors which are useful in treating various diseases and conditions involving chymase. Also disclosed are pharmaceutical compositions, methods of using and making...
8962625 Pyridazinone compound and use thereof  
A pyridazinone compound represented by the formula (I) has excellent effect on weed control and is useful as an active ingredient of herbicides.
8962640 Method for treating liver diseases of various origins  
The invention relates to medicine, in particular to gastroenterology, and lies in the field of treatment of liver diseases of various origins. For this purpose, the hepatoprotective agent that is...
8952010 Amino group-containing pyrrolidinone derivative  
A compound represented by the following formula (I) or a salt thereof: wherein R represents a hydrogen atom, a hydroxy group, or a halogen atomAr1 represents a bicyclic heterocyclic group...
8946220 Compositions and uses thereof to ameliorate pain  
Hydrazinopyridazines, fused hydrazinopyridazines, phenylethylhydrazines, or combinations thereof, compositions comprising hydrazinopyridazines, fused hydrazinopyridazines, phenylethylhydrazines,...
8946219 Combination therapy with a compound acting as a platelet ADP receptor inhibitor  
The present invention is directed to pharmaceutical compositions and methods of using combination therapies containing...
8940740 Small molecule inhibitors of bacterial motility and a high throughput screening assay for their identification  
Certain compounds are provided that can selectively inhibit motile bacteria such as V. cholerae motility. These compounds can indirectly diminish production of cholera toxin and other major...
8940741 Inhibitors of bruton's tyrosine kinase  
This application discloses 6-(2-Hydroxymethyl-phenyl)-2-methyl-2H-pyridazin-3-one derivatives according to generic Formula I: wherein, variables X, R, and Y4, are defined as described herein,...
8933076 Pyridazine compounds, compositions and methods  
The invention relates to novel chemical compounds, compositions and methods of making and using the same. In particular, the invention provides pyridazine compounds and/or related heterocyclic...
8933084 Macrocyclic compounds as Trk kinase inhibitors  
Compounds of Formula I: and pharmaceutically acceptable salts thereof, wherein ring A, ring B, W, m, D, R2, R2a, R3, R3a, and Z are as defined herein, are inhibitors of Trk kinases and are useful...
8927549 Adamantyl benzamide derivatives  
Embodiments of the present invention provide adamantyl benzamide derivatives and pharmaceutical compositions comprising adamantyl benzamide derivatives. Methods of use of such compounds and...
8921365 Pharmaceutical composition, substrate comprising a pharmaceutical composition, and use of a pharmaceutical composition  
The invention relates to the use of a pharmaceutical composition for the local treatment or prevention of a tissue infection at an infection site, the pharmaceutical composition comprising at...
8916558 Powders for reconstitution  
This invention relates to powders for reconstitution comprising the NNRTI TMC278 dispersed in certain water-soluble polymers, which can be used in the treatment of HIV infection.
8912186 Allosteric protein kinase modulators  
The invention provides specific small molecule compounds that allosterically regulate the activity or modulate protein-protein interactions of AGC protein kinases and the Aurora family of protein...
8906921 4-alkoxypyridazine derivatives as fast dissociating dopamine 2 receptor antagonists  
The present invention relates to (1-benzyl-piperidin-4-yl)-(4-alkoxy-pyridazin-3-y1)-amines that are fast dissociating dopamine 2 receptor antagonists, processes for preparing these compounds,...
8901124 Pyridazine amide compounds useful as SYK inhibitors  
The present invention relates to the use of novel triazolopyridine derivatives of formula I: wherein all variable substituents are defined as described herein, which are SYK inhibitors and are...
8901133 Heterocyclic compounds and uses thereof  
Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and...
8901132 Thiazolopyrimidine modulators as immunosuppressive agents  
The present invention relates to compound of formula I, II, III, or IV, and/or a pharmaceutical acceptable addition salt thereof and/or a stereoisomer thereof and/or a solvate thereof, wherein R1,...
8895555 Methods of treating intestinal diseases and inflammatory conditions related to HIV-AIDS  
Provided herein are methods of treating intestinal diseases or inflammatory conditions, including HIV-AIDS, in which oxidative stress is a triggering or exacerbating factor by administering GVT to...
8895554 Compounds, compositions and methods for the treatment of amyloid diseases and synucleinopathies such as Alzheimer's disease, type 2 diabetes, and Parkinson's disease  
Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the...
8889163 Facially amphiphilic polymers as anti-infective agents  
Facially amphiphilic polyphenylene and heteroarylene polymers and articles made therform having biocidal surfaces are disclosed. The polymers can inhibit the growth of microorganisms in contact...
8889681 Use and application of a pharmaceutical composition containing a mixture of natural-origin heterocyclical guanidine, for cosmetology, wound healing, focal dystonia and muscular spasm-related clinical pathologies  
Pharmaceutical compositions comprising tricyclic 3,4-propinoperhydropurines and uses thereof for the treatment of facial wrinkling are provided.
8883800 Substituted quinazolines, the preparation thereof and the use thereof in pharmaceutical compositions  
The present invention relates to substituted quinazolines of formula (I): wherein X and Y are defined as in claim 1, the tautomers, stereoisomers, mixtures and salts thereof, which have valuable...
8877754 Compounds, pharmaceutical compositions and uses thereof  
The invention relates to new compounds of the formula I to their use as medicaments, to methods for their therapeutic use and to pharmaceutical compositions containing them.
8871763 Use and application of a pharmaceutical composition containing a mixture of natural-origin heterocyclical guanidine, for cosmetology, wound healing, focal dystonia and muscular spasm- related clinical pathologies  
Pharmaceutical compositions comprising tricyclic 3,4-propinoperhydropurines and uses thereof for the treatment of facial wrinkling are provided.
8859548 Compounds and compositions as protein kinase inhibitors  
The present invention provides compounds of Formula I or II: wherein R1, R1b, R2, R3, R4, R5, R6 and R7 are defined herein. The compounds of Formula (I) or (II) and pharmaceutical compositions...
8859549 Potassium channel modulators  
Disclosed herein are KCNQ potassium channels modulators of formula (I) wherein ring G1, R1, and R2 are as defined in the specification. Compositions comprising such compounds; and methods for...
8853211 Pyridazinone derivatives  
Compounds of the formula (I) in which D, R1, R2, R3, R4 have the meanings indicated in Claim 1, are inhibitors of tyrosine kinases, in particular of Met kinase, and can be employed, inter alia,...
8841310 Combinations of a pyrimidine containing NNRTI with RT inhibitors  
The present invention concerns combinations of a pyrimidine containing NNRTI with nucleoside reverse transcriptase inhibitors and/or nucleotide reverse transcriptase inhibitors useful for the...
8841287 Diamino-pyridine, pyrimidine, and pyrazine modulators of the histamine H4 receptor  
Diamino-pyridine, pyrimidine and pyridazine compounds which may be used as H4 receptor modulators, and in pharmaceutical compositions and methods for the treatment of disease states, disorders,...
8841337 Compounds useful as inhibitors of ATR kinase  
The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this...
8828908 Herbicidally active bicyclic 1,3-dione compounds  
Bicyclic dione compounds of formula (I), and derivatives thereof, which are suitable for use as herbicides.
8815286 Pharmaceutical composition for treating hypertension and metabolic syndrome and use thereof  
The present invention provides a pharmaceutical composition comprising the following active ingredients: 1) an angiotensin II receptor antagonist or a pharmaceutically acceptable salt thereof, 2)...
8809302 Therapeutic approaches for treating alzheimer'S disease  
The present invention relates to compositions and methods for the treatment of Alzheimer's disease and related disorders. More specifically, the present invention relates to novel combinatorial...
8809379 Selective subtype alpha 2 adrenergic agents and methods for use thereof  
The invention provides well-defined heterocyclic compounds that are useful as subtype selective alpha 2 adrenergic agonists. As such, the compounds described herein are useful in treating a wide...
8802666 Inhibitors of cyclophilins and uses thereof  
The present invention relates to a compound of formula (I): wherein: n is 0, 1 or 2;A is in particular CH or N;X is in particular CO, SO2, CS, and R1 is in particular H,R2 is a group of formula...
8791116 Myosin light chain kinase inhibitor compounds, compositions and related methods of use  
Pyridazinyl compounds, compositions and related methods of use.