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9040021 Heterocyclic compounds as imaging probes of tau pathology  
Heterocyclic compounds of formula (I) useful as imaging probes of Tau pathology in Alzheimer's disease are described. Compositions and methods of making such compounds are also described.
8987257 Heterocyclic derivatives  
The invention relates to novel heterocyclic compounds of the formula in which all of the variables are as defined in the specification, to their preparation, to their medical use, in particular to...
8957071 Treatment of vascular, autoimmune and inflammatory diseases using low dosages of IMPDH inhibitors  
The disclosure provides methods and compositions for treating a vascular, autoimmune, and/or inflammatory disease, or a condition associated therewith, with a dose of an inosine monophosphate...
8940724 Quinoline derivitives and their uses  
Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders,...
8940736 Imidazotriazinecarbonitriles useful as kinase inhibitors  
The invention provides compounds of Formula (I) and pharmaceutically acceptable salts thereof. The Formula (I) imidazotriazines inhibit protein kinase activity thereby making them useful as...
8791090 Prophylactic and/or therapeutic agent for anemia comprising tetrahydroquinoline compound as active ingredient  
Disclosed is a compound which has a low molecular weight and has an activity of enhancing the production of EPO and/or an activity of enhancing the production of hemoglobin. Specifically disclosed...
8765731 Benzimidazole analogues for the treatment or prevention of flavivirus infections  
Compounds represented by formula I: or pharmaceutically acceptable salts and solvates thereof, wherein A, B, B′, X, Y, R1, R1′, R2, R2′, R3, R3′, R5, R5′, R6, m, n, or p are as defined herein, are...
8680095 Heterocycle compounds and uses thereof for the prevention or treatment of diseases involving formation of amyloid plaques and/or where a dysfunction of the APP metabolism occurs  
The present invention relates to compounds having the following Formula (I) for use in the prevention and/or the treatment of diseases involving formation of amyloid plaques and/or where a...
8664218 Pharmaceutical compounds  
The invention provides a compound of the formula (1): or a salt, solvate, N-oxide or tautomer thereof.
8658640 JNK inhibitors for the treatment of endometriosis  
This invention relates to a method of treating and/or preventing endometriosis comprising administering a JNK inhibitor. The JNK inhibitor can also be administered combined with a hormonal...
8592414 JNK inhibitors for the treatment of endometriosis  
This invention relates to a method of treating and/or preventing endometriosis comprising administering a JNK inhibitor. The JNK inhibitor can also be administered combined with a hormonal...
8586580 2,7-substituted thieno[3,2-d] pyrimidine compounds as protein kinase inhibitors  
Disclosed are a 2,7-substituted thieno[3,2-d]pyrimidine compound having a protein kinase inhibition activity, a pharmaceutically acceptable salt, and a pharmaceutical composition for prevention...
8563540 Pyrido[3,2-d]pyrimidine PI3K delta inhibitor compounds and methods of use  
Formula I compounds, including stereoisomers, geometric isomers, tautomers, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting the delta isoform of PI3K, and for...
8557807 Thienopyranones as kinase inhibitors  
The invention, relates to compounds of formula I (or pharmaceutically acceptable salts thereof) as defined herein, pharmaceutical compositions thereof, and their use in manufactures and methods...
8545877 Modified drugs for use in liposomal nanoparticles  
Drug derivatives are provided herein which are suitable for loading into liposomal nanoparticle carriers. In some preferred aspects, the derivatives comprise a poorly water-soluble drug...
8455252 Materials and methods for sensitizing multidrug resistant cells  
Disclosed herein are materials and methods for sensitizing multidrug resistant cancer cells that express ABCG2 and related proteins members of a family of ATP-binding transporter superfamily that...
8445487 Purine PI3K inhibitor compounds and methods of use  
Purine compounds of Formula I, and including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting lipid...
8440651 Pyrido[3,2-d]pyrimidine PI3K delta inhibitor compounds and methods of use  
Formula I compounds, including stereoisomers, geometric isomers, tautomers, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting the delta isoform of PI3K, and for...
8435985 Pyrido-, pyrazo- and pyrimido-pyrimidine derivatives as mTOR inhibitors  
There is provided a compound of formula I: or a pharmaceutically acceptable salt thereof. There are also provided processes for the manufacture of a compound of Formula 1, and the use of a...
8389516 Antibacterial compositions  
Compounds of formula (I) have antibacterial activity: wherein: m is 0 or 1; Q is hydrogen or cyclopropyl; Alk is an optionally substituted, divalent C1-C6 alkylene, alkenylene or alkynylene...
8383619 Pharmaceutical compounds  
The invention provides a compound of the formula (1): or a salt, solvate, N-oxide or tautomer thereof; wherein either R1 is R1a and R2 is R2a; or R1 is R1b and R2 is R2b; provided that in each...
8354400 Benzoxazole compounds and methods of use  
The present invention provides benzoxazole compounds and pharmaceutically acceptable salts thereof and pharmaceutical compositions including the same. The present invention further provides...
8349845 Thiazolopyrimidines for use in therapy  
Use of a compound of formula (I) wherein R is an alicyclic group; an arylethyl group; or phenyl or benzyl substituted by halogen, lower alkyl, alkoxy, OH, NH2, NHalkyl, N(alkyl)2, CN or NO2; in...
8343957 Therapeutic pyrazoloquinoline urea derivatives  
The invention provides a novel chemical series of formula I, as well as methods of use thereof for binding to the benzodiazepine site of the GABAA receptor and modulating GABAA, and use of the...
RE43878 Amidophenoxyindazoles useful as inhibitors of c-Met  
The present invention provides amidophenoxyindazole compounds useful in the treatment of cancer.
8338414 Immunosuppressive agent and anti-tumor agent comprising heterocyclic compound as active ingredient  
A novel method for immunosuppressive in a mammal suffering from an immune disease, including administering to the mammal a therapeutically effective amount of a heterocyclic compound represented...
8314098 Pyrazolo-pyrimidine compounds  
The present invention has searched for a variety of compounds which show IL-12/IL-23 production-inhibitory activities and herein provides a pharmaceutical composition and an agent for preventing...
8263584 Imidazopyridines  
The invention is concerned with novel imidazopyridine derivatives of formula (I) wherein R1, R2, R3, R4, R5 and A are as defined in the description and in the claims, as well as physiologically...
8198316 Process for the preparation of 5,6 -dihydro -4H-4(S)-ethylamino-6(S)-methylthieno[2,3-b] thiopyran-2-sulfonamide- 7,7 -dioxide and its salt  
The present invention relates to resolution of (cis,trans)5,6-dihydro-4H-4-ethylamino-6-methylthieno[2,3-b] thiopyran-2-sulfonamide-7,7-dioxide using dibenzoyl-L-tartaric acid monohydrate or...
8193164 Organic compounds  
A compound of formula (I), or stereoisomers or pharmaceutically acceptable salts thereof, wherein, R1a, R1b, R2a, R2b, U1, U2, X1, X2 and L are as defined herein.
8173648 1,2,3,4-tetrahydroisoquinoline derivatives, preparation process therefor and pharmaceutical composition containing the same  
The invention provides a type of novel 1,2,3,4-tetrahydroisoquinoline derivatives with a structure of formula (I): wherein R1 represents propargyl or cyclopropylmethyl; wherein R2 represents...
8101602 Pyrido-, pyrazo- and pyrimido-pyrimidine derivatives as mTOR inhibitors  
There is provided a compound of formula I: or a pharmaceutically acceptable salt thereof. There are also provided processes for the manufacture of a compound of Formula 1, and the use of a...
8030302 Amidophenoxyindazoles useful as inhibitors of c-Met  
The present invention provides amidophenoxyindazole compounds useful in the treatment of cancer.
7973030 Benzothiazepine and benzothiepine compounds  
A pharmaceutical useful as a therapeutic agent and a preventive agent for hyperlipemia, and a pharmaceutical useful as a therapeutic agent and a preventive agent for hepatic disorders associated...
7951801 Beta-carbolines useful for treating inflammatory disease  
This invention provides beta-carboline compounds of formula III-A-aa: wherein Q, G, R1, R2, R3, and R6b are as described in the specification. The compounds are useful for treating diseases such...
7951802 Use of 7-azaindoles in the inhibition of c-Jun N-terminal kinase  
The present invention provides a compound of formula (I); or a pharmaceutically acceptable salt thereof in the inhibition of c-Jun N-terminal kinase (JNK) activity and particularly in the...
7902189 Compounds  
There is provided a compound of formula I: or a pharmaceutically acceptable salt thereof. There are also provided processes for the manufacture of a compound of Formula 1, and the use of a...
7855199 Heterocyclic compound and anti-malignant-tumor agent containing the same as active ingredient  
Heterocyclic compounds represented by the formula I and anti-malignant-tumor agents containing the heterocyclic compounds as effective components: wherein X represents nitrogen atom or CH; Y...
7776854 Benzazole derivatives for the treatment of scleroderma  
The present invention is related to the use of benzazole derivatives of formula (I) for the treatment and/or prevention of scleroderma and its therapeutic implications selected in the group...
7727985 Beta-carbolines useful for treating inflammatory disease  
This invention provides beta-carboline compounds of formula I: wherein Ring A is a substituted pyridinyl, pyrimidinyl, morpholinyl, piperidinyl, piperazinyl, pyrrolidinyl, pyranyl,...
7718653 Pyrimidine derivatives for inhibiting Eph receptors  
A compound of formula (I) where one of A1, A2 or A3 is N, and the others are independently selected from CH or N; ring B is a fused 5 or 6-membered carbocyclic or heterocyclic ring which is...
7696203 DNA-PK inhibitors  
Compounds of formula I: wherein A, B and D are respectively selected from the group consisting of: (i) CH, NH, C;(ii) CH, N, N; and(iii) CH, O, C;the dotted lines represent two double bonds in the...
7678792 Compositions and methods for modulating c-kit and PDGFR receptors  
The invention provides compounds and pharmaceutical compositions thereof, which are useful as protein kinase inhibitors, as well as methods for using such compounds to treat, ameliorate or prevent...
7622497 Derivatives of gambogic acid and analogs as activators of caspases and inducers of apoptosis  
The present invention is directed to novel derivatives of gambogic acid and analogs thereof. The present invention also relates to the discovery that novel derivatives of gambogic acid are...
7576079 Viral polymerase inhibitors  
An isomer, enantiomer, diastereoisomer or tautomer of a compound, represented by formula I: wherein: A is O, S, NR1, or CR1, wherein R1 is defined herein; represents either a single or a double...
7482342 Indazolecarboxamide derivatives, preparation and use thereof as CDK1, CDK2 and CDK4 inhibitors  
Compound corresponding to general formula (I): in which, R1 represents a hydrogen or halogen atom, an NH2, NHR2, NHCOR2, NO2, CN, CH2NH2 and CH2NHR2; or alternatively R1 represents an optionally...
7417066 Inhibitors of soluble adenylate cyclase  
The invention relates to compounds of general Formula I, the production thereof, and the use thereof as a medicinal product.
7414073 Cytotoxic agents containing novel potent taxanes and their therapeutic use  
Included within the scope of the present invention are potent taxanes and taxanes containing a linking group. Also included is a cytotoxic agent comprising one or more taxanes linked to a cell...
7410990 Heterocyclic compounds  
This invention features a compound of formula (I): R1 is aryl or heteroaryl; each of R2 and R4, independently, is H, halogen, CN, alkyl, ORa, or NRaRb; R3 is H, halogen, CN, alkyl, alkenyl,...
7405211 Therapeutic morpholino-substituted compounds  
Morpholino-substituted pyridopyrimidine, quinolone, and benzopyranone derivatives inhibit phosphoinositide (PI) 3-kinase, an enzyme that regulates platelet-adhesion processes. As a consequence,...

Matches 1 - 50 out of 292 1 2 3 4 5 6 >