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8921359 Inhibitors of beta-secretase  
The present invention is directed to a compound represented by the following structural formula: or a pharmaceutically acceptable salt thereof. Pharmaceutical composition comprising a compound...
8895548 Pharmaceutical composition for treating alzheimer's disease  
A pharmaceutical composition for treating Alzheimer's disease containing a compound represented by the general formula (I): wherein ring A is an optionally substituted carbocyclic group or an...
8802128 Steroid-containing sustained release intraocular implants and related methods  
Biocompatible intraocular implant systems are formulated for discontinuous or intermittent release of therapeutic levels of a therapeutic agent (such as a steroid) to minimize development of side...
8673953 Compositions and methods for treating purpura  
Embodiments of the present invention are directed to compositions and methods for the treatment of purpura. Preferred compositions comprise an α adrenergic receptor agonist selected from selective...
8653067 Pharmaceutical composition for treating Alzheimer's disease  
A pharmaceutical composition for treating Alzheimer's disease containing a compound represented by the general formula (I); wherein ring A is an optionally substituted carbocyclic group or an...
8637504 Sulfur-containing heterocyclic derivative having beta secretase inhibitory activity  
The following compound is provided as an agent for treating a disease induced by production, secretion and/or deposition of amyloid β protein, for example, a compound represented by the formula...
8546380 Aminodihydrothiazine derivatives  
A composition having BACE 1 inhibitory activity containing a compound represented by the formula (I): wherein ring A is an optionally substituted heterocyclic group; E is lower alkylene; X is S;...
8541408 Aminodihydrothiazine derivatives substituted with a cyclic group  
This invention provides a compound of the formula (I): wherein the ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; R1 is optionally...
8450309 Arthroscopic irrigation solution and method for peripheral vasoconstriction and inhibition of pain and inflammation  
A method and solution for perioperatively inhibiting a variety of pain and inflammation processes during arthroscopic procedures. The solution preferably includes a vasoconstrictor that exhibits...
8222246 Substituted isoxazoles  
The present invention is concerned with novel hydroxy-methyl isoxazole derivatives of formula I wherein R1, R2 and R3 are as described herein, as well as pharmaceutically acceptable salts and...
8173642 Aminodihydrothiazine derivatives  
A composition having BACE 1 inhibitory activity containing a compound represented by the general formula (I): wherein ring A is an optionally substituted carbocyclic group or an optionally...
8168630 Aminodihydrothiazine derivatives substituted with a cyclic group  
This invention provides a compound of the formula (I): wherein the ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; R1 is optionally...
8114898 Compositions and methods for treating purpura  
Embodiments of the present invention are directed to compositions and methods for the treatment of purpura. Preferred compositions comprise an α adrenergic receptor agonist selected from selective...
8039465 Cytoskeletal active compounds, composition and use  
The present invention is directed to synthetic cytoskeletal active compounds that are related to natural Latrunculin A or Latrunculin B. The present invention is also directed to pharmaceutical...
8026266 Treatment of length dependent neuropathy  
Compositions, and methods of use thereof, are provided for the treatment of painful neuropathy by local or topical delivery of compounds that interact with α-adrenergic receptors, especially an...
RE42562 EP4 receptor agonist, compositions and methods thereof  
This invention relates to potent selective agonists of the EP4 subtype of prostaglandin E2 receptors, their use or a formulation thereof in the treatment of glaucoma and other conditions, which...
7932245 Spirocyclopropyl amides and acids and their therapeutic applications  
The present invention relates to the use of compounds of formula (I) for the treatment of epilepsy, bipolar disorder, psychiatric disorders, migraine, pain, or movement disorders, and to provide...
7659280 2,4-pyrimidinediamine compounds for treating or preventing autoimmune diseases  
The present invention provides 3-hydroxyphenyl-2,4-pyrimidinediamine compounds of formula I, as well as related compositions and methods for treating a variety of autoimmune diseases.
7648983 BACE inhibitors  
The present invention provides BACE inhibitors of Formula I: methods for their use, and intermediates and methods for their preparation.
7482339 2-Naphthylimino-1,3-thiazine derivative  
The formula (I): wherein each of R2 and R3 is, same or different, C2-C4 alkyl or the like; or R2 and R3 are taken together with the adjacent carbon atom to form a 5 to 8 membered non-aromatic...
7452879 Methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds  
The present invention provides methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds, as well as methods of treating, preventing or ameliorating symptoms...
7375102 Tetrahydroquinazolin-4(3H)-one-related and tetrahydropyrido[2,3-D]pyrimidin-4(3H)-one-related compounds, compositions and methods for their use  
Compounds are provided having the formula: wherein variables A1, A2, A3, A4, R1, R2, R3, R4, Q and L are as described herein. The subject compounds are useful for treatment of inflammatory and...
7223754 Thiazolidinone, oxazolidinone, and imidazolone derivatives for treating lower urinary tract and related disorders  
The invention relates to methods of using Cav2.2 subunit calcium channel modulators, particularly thiazolidinone, oxazolidinone, and imidazolone derivatives, to treat lower urinary tract and...
7183275 2-imino-1,3-thiazine derivatives  
The present invention relates to 2-imino-1,3-thiazine derivatives, in specific, 2-imino-1,3-thiazine derivatives having a selective antagonistic activity or agonistic activity to a cannabinoid...
7132451 Inhibition of TNF-α-initiated neutrophil response  
The impact of lipoxin A4 (LXA4) and aspirin-triggered-lipoxins (ATL) was investigated in tumor necrosis factor (TNFα)-initiated neutrophil (PMN) responses in vitro and in vivo using metabolically...
7094778 Heterocyclylalkylamines as muscarinic receptor antagonists  
This invention relates to compounds which are generally muscarinic M2/M3 receptor antagonists and which are represented by Formula I: wherein X, Y, and Z are O, S or NR5, and the other...
7087627 Combinations for the treatment of diseases involving angiogenesis  
Compositions for the inhibition of the formation of new vasculature by angiogenesis are provided comprising the combination of a vasculature damaging agent and an inhibitor of the formation or...
7084137 Thiazines and thiazoles as agents for protecting materials  
The novel and known thiazines and thiazoles of the formula (I) in which R1, R2 and n are as defined in the description, are highly suitable for use as biocides for protecting industrial materials.
7053085 EP4 receptor agonist, compositions and methods thereof  
This invention relates to potent selective agonists of the EP4 subtype of prostaglandin E2 receptors, their use or a formulation thereof in the treatment of glaucoma and other conditions, which...
6916806 Medicinal composition containing 1,3-thiazine derivative  
A compound of the formula (I) having a binding activity to the cannabinoid type 2 receptor: wherein R1 is optionally substituted heterocyclic group or the like; R2 and R2 each is independently...
6827942 Composition and method of use  
A liquid composition comprising an alcohol or mixture thereof in sufficient quantity to grow hair in an area of canine or feline skin wherein alopecia has occurred.
6818640 2-imino-1,3-thiazine derivatives  
It is found out that compounds represented by general formula (I) bind selectively to cannabinoid 2 receptor (CB2R) and thus exhibit CB2R antagonism or CB2R agonis wherein R1 represents optionally...
6806291 Analgesic compounds, their synthesis and pharmaceutical compositions containing them  
New analgesic compounds, which are prepared by the hydrolysis of N-acylated 4-hydroxyphenylamine derivatives, their synthesis and pharmaceutical compositions containing them are disclosed. These...
6794406 Indole derivatives  
The invention relates to new indole derivatives, processes for their preparation, and their use in medicaments.
6767907 4-aryl-1-(indanmethyl dihydrobenzofuranmethyl or dihydrobenzothiophenemethyl) piperidines tetrahydropyridines or piperazines  
4-Aryl-1-(indanmethyl, dihydrobenzofuranmethyl or dihydrobenzothiophenemethyl)piperidine, -tetrahydropyridine or -piperazine compounds of general formula (I), wherein one of X and Y is CH2 and the...
6610720 Method for treating or preventing emesis  
Alpha-2 adrenoreceptor agonists are useful for the treatment and/or prevention of emesis in patients.
6534492 Uracil substituted phenyl sulfamoyl carboxamides  
Novel uracil substituted phenyl sulfamoyl carboxamides I and salts thereof, whereA=oxygen or sulfur;X1=H, halogen, C1-C4-alkyl;X2=H, CN, CS—NH2, halogen, C1-C4-alkyl, C1-C4-haloalkyl;X3=H, CN,...
6512004 Promoters of neural regeneration  
The invention provides methods and compositions for promoting neural cell growth and/or regeneration. The general methods involve contacting with an activator of a cyclic nucleotide dependent...
6469000 1,3-diheterocyclic metalloprotease inhibitors  
Disclosed are compounds which are inhibitors of metalloproteases having the following structure: where Ar, W, X, Y, Z, R1 and R2 have the meanings described in the specification and optical...
6448286 Imino pyrrolidine derivatives useful as nitric oxide synthase inhibitors  
The current invention discloses useful pharmaceutical compositions containing amidino derivative useful as nitric oxide synthase inhibitors.
6429206 Non-systemic control of parasites  
Use of agonists and antagonists of the nicotinergic acetylcholine receptors of insects for the non-systemic control of parasitic insects, such as fleas, lice and flies, on humans and on animals.
6395730 Potassium channel inhibitors  
Certain thiazolidinone and metathiazanone compounds, as described, are useful as potassium channel inhibitors and are especially useful for the treatment of cardiac arrhythmias and other diseases,...
6303638 Substituted pyridines as modulators of the mammalian neuronal nicotinic acetylcholine receptor  
Novel compounds are provided that modulate the neuronal nicotinic acetylcholine receptor (nAChR), particularly the mammalian nAChR (m-nAChR). The compounds are substituted pyridine derivatives...
6268352 Promoters of neural regeneration  
The invention provides methods and compositions for promoting neural cell growth and/or regeneration. The general methods involve contacting with an activator of a cyclic nucleotide dependent...
6218394 4-Aryl-1-(indanmethyl, dihydrobenzofuranmethyl or dihydrobenzothiophene-methyl) piperazines  
4-Aryl-1-(indanmethyl, dihydrobenzofuramethyl or dihydrobenzothiophenemethyl) piperidine, -tetrahydropyridine or -piperazine compounds of general formula (I) ##STR1##wherein one of X and Y is CH2,...
6218359 Screening method using the RZR receptor family  
The current invention concerns the use of a receptor from the RZR/ROR receptor family or of a functional fragment thereof in a test of a compound for anti-autoimmune, anti-arthritic, anti-tumor,...
6172060 Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses  
Disclosed are nitrosated and/or nitrosylated phosphodiesterase inhibitors having the formula NOn -PDE inhibitor where n is 1 or 2. The invention also provides compositions comprising such...
6159995 Substituted diaminocarboxylic acids  
Compounds of formula (I) ##STR1## are suitable for the production of pharmaceuticals for the prophylaxis and therapy of disorders in the course of which an increased activity of matrix-degrading...
6156772 Antagonists of gonadotropin releasing hormone  
There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety...
6127372 Sulfonamide inhibitors of aspartyl protease  
This invention provides a novel class of sulfonamide compounds of formula I which are aspartyl protease inhibitors: ##STR1## This invention also provides pharmaceutical compositions comprising...

Matches 1 - 50 out of 154 1 2 3 4 >