Matches 1 - 50 out of 145 1 2 3 >


Match Document Document Title
8900565 Indole derivatives as inhibitors of histone deacetylase  
Described herein are compounds and pharmaceutical compositions containing such compounds, which inhibit the activity of histone deacetylase 8 (HDAC8). Also described herein are methods of using...
8877738 Antipathogenic peptides  
The present invention relates to monomeric and multimeric peptidic compounds which have antipathogenic, in particular antiviral or/and antibacterial activity. In a preferred aspect, the peptide...
8821877 Methods for inhibiting HIV-1 replication involving the administration of an anti-CCR5 receptor monoclonal antibody and small molecule CCR5 receptor antagonist  
This method provides a method for reducing HIV-1 viral load in an HIV-1-infected human subject which comprises administering to the subject at a predefined interval effective HIV-1 viral...
8802240 Uses of formulations of thyroid hormone analogs and nanoparticulate forms thereof to increase chemosensitivity and radiosensitivity in tumor or cancer cells  
Disclosed are methods of increasing the chemosensitivity of normal and/or chemoresistant tumor or cancer cells using thyroid hormone analogs and/or nanoparticulate or polymeric forms thereof. Also...
8778961 O-methylated rapamycin derivatives for alleviation and inhibition of lymphoproliferative disorders  
The present invention relates to methods of alleviating and inhibiting a lymphoproliferative disorder in a mammal, the method comprising administering one or more rapamycin derivatives (including...
8759375 Methods for treating multiple myeloma using 4-(amino)-2-(2,6-dioxo(3-piperidyl))-isoindoline-1,3-dione in combination with proteasome inhibitor  
Methods of treating, preventing and/or managing cancer as well as and diseases and disorders associated with, or characterized by, undesired angiogenesis are disclosed. Specific methods encompass...
8759370 O-methylated rapamycin derivatives for alleviation and inhibition of lymphoproliferative disorders  
The present invention relates to methods of alleviating and inhibiting a lymphoproliferative disorder in a mammal, the method comprising administering one or more rapamycin derivatives (including...
8754078 Compositions and methods for treatment of cancer  
The present invention relates to pyrroloquinolinyl-pyrrolidine-2,5-dione compounds in combination with chemotherapeutic agents. The present invention provides methods of treating a cell...
8664195 Phosphorus-containing prodrugs  
Novel cyclic phosphoramidate prodrugs of drugs of formula I their use in delivery of drugs to the liver, their use in enhancing oral bioavailability, and their method of preparation are described.
8642578 Elastin protective polyphenolics and methods of using the same  
Dermal fibroblasts permanently loose their ability to synthesize elastin, the major component of elastic fibers, shortly after puberty. This progressive loss of elastic fibers cannot be replaced,...
8563003 Method for the treatment of malignant and infectious chronic diseases  
The present invention relates to methods of treatment useful in chronic diseases, by means of the rupture of tolerance to self-antigens and increasing autoimmune response against these antigens....
8546091 AKT phosphorylation at Ser473 as an indicator for taxane-based chemotherapy  
Methods for determining whether a cancer patient is likely to benefit from treatment with a taxane compound based on Akt-Ser473 phosphorylation status are provided, together with kits for...
8309537 Compositions and methods for treating colitis  
Disclosed herein are compositions and methods for treating colitis and other inflammatory bowel diseases, inter alia, indeterminate colitis, Crohn's disease, irritable bowel syndrome and ischemic...
8236820 Anti-inflammatory compounds and uses thereof  
Compounds of the general formula are disclosed with activity towards treating diseases related to inflammation, such as cancer, neurodegenerative and cardiovascular diseases. Pharmaceutical...
8093230 Supersaturated aqueous ifosfamide compositions  
The invention concerns the use of mercaptoethane sulfonate-sodium (Mesna) to increase the solubility of Ifosfamide in storage-stable, concentrated and/or highly-concentrated (supersaturated)...
8080536 Phosphorus-containing prodrugs  
Novel cyclic phosphoramidate prodrugs of drugs of formula I their use in delivery of drugs to the liver, their use in enhancing oral bioavailability, and their method of preparation are described.
8017135 Lipid-drug conjugates for local therapy of eye diseases  
Methods are provided for treating pathological conditions of ocular tissue by administering to subjects in need thereof therapeutically active complexes that include amphiphilic analogs of the...
7981874 Phosphorus derivatives as histone deacetylase inhibitors  
The present invention relates to a novel class of phosphorus derivatives. The phosphorus compounds can be used to treat cancer. The phosphorus compounds can also inhibit histone deacetylase and...
7838513 Anti-cancer therapy comprising an H2-blocker, at least one antiinflammatory agent and a cytotoxic agent  
The present invention relates to the treatment of a mammal with a pharmaceutical composition comprising an H2-blocker, at least one anti-inflammatory agent, a cytotoxic agent and, optionally,...
7816345 Phosphorus-containing prodrugs  
Novel cyclic phosphoramidate prodrugs of drugs of formula I their use in delivery of drugs to the liver, their use in enhancing oral bioavailability, and their method of preparation are described.
7807683 N-heteroaryl pyrazolopyrimidines as cyclin dependent kinase inhibitors  
In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds,...
7790703 Phosphonate compounds  
The present invention relates to phosphonate compounds, compositions containing them, processes for obtaining them, and their use for treating a variety of medical disorders, e.g., osteoporosis...
7514442 Trisubstituted 4-aminopyrazolopyrimidines as cyclin dependent kinase inhibitors  
In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds,...
7498320 Cyclic phosphate diesters of 1,3-propane-1-aryl diols and their use in preparing prodrugs  
Compounds of Formula I, their preparation and synthetic intermediates, and their use in the synthesis of prodrugs: wherein:V and L are trans relative to one another;V is selected from group...
7470695 N-heteroaryl pyrazolopyrimidines as cyclin dependent kinase inhibitors  
In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds,...
7326695 Anti-bacterial agents based upon oxoanion binding  
Compounds of the structure I: are useful for treating bacterial growth, wherein E is selected from the group consisting of B, P, and S, T1 and T2 are each independently selected from the group...
7297330 Low dose haptenized tumor cell and tumor cell extract immunotherapy  
This invention relates to compositions comprising haptenized tumor cells and extracts thereof, methods for preparing the compositions, vaccines comprising such haptenized tumor cells, and methods...
7199111 Aqueous ifosfamide compositions for parenteral administration and a process for their preparations  
The present invention provides aqueous Ifosfamide compositions and a process for their preparation, in which the compositions have a reduced toxicity over and above the concomitant use of the...
7199162 Use of treosulfan for patient conditioning before bone marrow or blood stem cell transplantation  
The invention relates to the use of treosulfan as a conditioning agent before allogenic transplantation of bone marrow or haematopoietic stem cells, whereby treosulfan is administered, either as...
7182942 Vaccine immunotherapy for immune suppressed patients  
A method of immunotherapy to treat cancer or a synergistic anti-cancer treatment by administering an effective amount of a natural cytokine mixture (NCM), an effective amount of cyclophosphamide...
7163703 Compositions and methods for the treatment of primary and metastatic neoplastic diseases using arsenic compounds  
The invention relates to the use of arsenic compounds to treat a variety of neoplastic diseases. The present invention encompasses the administration to a mammal of arsenic in the form of a salt,...
7160865 Cancer treatment including glycolytic inhibitors  
Glycolytic inhibitors are useful in the treatment of solid tumors by attacking anaerobic cells at the center on the tumor. 2-deoxyglucose, oxamate and various analogs thereof are identified as...
7151092 Cytarabine monophosphate prodrugs  
Compounds of Formula I, their preparation and uses are described: wherein: M and V are cis to one another and MH is cytarabine;the 5′ oxygen of said cytarabine is attached to the phosphorus;V is...
7094772 Phosphonate compounds  
The present invention relates to phosphonate compounds, compositions containing them, processes for obtaining them, and their use for treating a variety of medical disorders, e.g., osteoporosis...
6964952 Therapeutic composition for broad spectrum dermal disease  
The invention relates to a therapeutic composition for broad spectrum dermal disease and in particular, to a composition comprising principal lipid components of skin, preferably having about 30...
6949529 Compositions containing lysophosphotidic acids which inhibit apoptosis and uses thereof  
The present invention provides therapeutic compositions containing lysophosphatidic acids, methods for making the compositions, and methods of use thereof.
6919322 Phenyl Phosphonate Fructose-1,6-Bisphosphatase Inhibitors  
Novel FBPase inhibitors of the formula I are useful in the treatment of diabetes and other conditions associated with elevated blood glucose.
6914056 Pharmaceutical compositions comprising cyclic glycerophosphates and analogs thereof for promoting neural cell differentiation  
Cyclic glycerophosphates and analogs thereof (CGs) are shown to exert neutral promoting activities in target cells. Such activities include promotion of neuronal outgrowth, promotion of nerve...
6809120 Composition containing propargylamine for enhancing cancer therapy  
Antineoplastic drug modulators are described. The specific modulators referred to are propargylamines which can enhance the cytotoxic effects of antineoplastic drugs on cancer cells while...
6784169 MMP inhibitors  
Novel compounds according to formula I n is 0, 1, 2 or 3;X represents hydroxamic acid (CONHOH), carboxylic acid, phosphonic acid, acetylthiomethyl group or a mercaptomethyl group; R2, R10 and R11...
6762174 Low molecular weight compounds administered together with anti-cancer agents to prevent or treat cancer and pharmaceutical compositions thereof  
The present invention relates to peptide-like compounds, e.g. aminocarboxylic acid amide derivatives, and to methods of using same to stimulate cells of the immune system, bone marrow and other...
6635627 Anti-cancer products for treating cystic fibrosis  
The invention concerns a novel approach for treating cystic fibrosis using, in particular, anti-cancer chemotherapy. For the treatment of cystic fibrosis it proposes the use of at least one...
6630442 Reparatives for chemosurgery and laser (thermal) therapy  
A composition of glutathione and selenium, as a selenoamino acid or selenium yeast extract and an epidermal growth factor in a topical carrier and method of using the composition to reduce and...
6566304 Biogenic control and limitation of the reproduction of parasitic earth nematodes in stock culture  
The invention relates to use of (a) compounds of phosphorus containing at least partly lipophilic organic radicals together with (b) urea and/or urea derivatives in selected quantity ratios of (a)...
6559139 Combination chemotherapy  
This invention relates to combination chemotherapy, particularly involving vitamin D or a derivative thereof. In one aspect, the invention provides a method of killing a cell by first...
6440951 Method for treatment of diabetes  
Fosfomycin or a pharmaceutically acceptable salt thereof has been found to have an action of lowering the serum glucose level and is recognized to be useful as an orally administrable remedy for...
6413947 Anilide derivative, production and use thereof  
This invention is to provide a compound of the formula: wherein R1 is an optionally substituted 5- to 6-membered ring; W is a divalent group of the formula: wherein the ring A is an optionally...
6413946 Composition for treatment of diabetes and treatment of diabetes  
Fosfomycin or a pharmaceutically acceptable salt thereof has been found to have an action of lowering the serum glucose level and is recognized to be useful as an orally administrable remedy for...
6372719 α&ngr β3 integrin antagonists in combination with chemotherapeutic agents  
The present invention is directed to compounds of the formula and pharmaceutically acceptable salts and isomers thereof administered in combination with chemotherapeutic agents.
6329355 Method for inhibiting the growth of cancers  
A method for inhibiting the growth of tumors and cancers in mammals comprising administering a chemotherapeutic agent to significantly reduce the tumor in mass and then administering a...

Matches 1 - 50 out of 145 1 2 3 >