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9040463 Assay device and method for performing biological assays  
The invention provides a multiplexed assay device comprising a reaction chamber and several sets of encoded microcarriers 2 wherein the reaction chamber is a microchannel 1 and wherein the...
9040258 Multi-chain eukaryotic display vectors and uses thereof  
A eukaryotic expression vector capable of displaying a multi-chain polypeptide on the surface of a host cell is provided, such that the biological activity of the multi-chain polypeptide is...
9039888 Methods and apparatus for detecting molecular interactions using FET arrays  
Methods and apparatuses relating to large scale FET arrays for analyte detection and measurement are provided. ChemFET (e.g., ISFET) arrays may be fabricated using conventional CMOS processing...
9040464 Markers of the male urogenital tract  
Methods for detecting urogenital conditions or urogenital status in a subject are described comprising measuring urogenital markers or polynucleotides encoding the markers in a sample from the...
9034797 Array printing  
The invention provides a method of printing, onto a substrate (12), an array (14) of spots of reagent compositions for use in a chemical and/or biochemical analysis. The method includes displacing...
9034601 Multi-chain eukaryotic display vectors and uses thereof  
A eukaryotic expression vector capable of displaying a multi-chain polypeptide on the surface of a host cell is provided, such that the biological activity of the multi-chain polypeptide is...
9028874 Antioxidant nanosphere comprising [1,2]-dithiolane moieties  
The present invention is directed to multiple a-lipoic acid-containing hydrophobic compounds (mALAs) capable of acting as scavengers of free radicals, metals and reactive oxygen species (ROS)....
9029297 Array printing  
The invention provides a method of printing, onto a substrate (12), an array (14) of spots of reagent compositions for use in a chemical and/or biochemical analysis. The method includes displacing...
9023767 γ-Secretase substrates and methods of use  
Polypeptide substrates based on modifications or fragments of the various APP isoforms, assay methods based on the use of these substrates, and screening methods directed toward identifying...
9023768 Strategies for high throughput identification and detection of polymorphisms  
The invention relates to a method for the high throughput identification of single nucleotide polymorphisms by performing a complexity reduction on two or more samples to yield two or more...
9023766 Method and arrays for detecting biological molecules  
Arrays and methods for detecting one or more biological molecules, where the methods generally comprise the steps of: providing a first support structure fixed with one or more reagents; providing...
9012370 Method for measuring chromosome, gene or specific nucleotide sequence copy numbers using SNP array  
The present invention relates to a method for measuring the copy number of a chromosome, gene or specific nucleotide sequence, comprising the steps of: (a) mixing a homozygous DNA with a test...
9012181 Multi-chain eukaryotic display vectors and uses thereof  
A eukaryotic expression vector capable of displaying a multi-chain polypeptide on the surface of a host cell is provided, such that the biological activity of the multi-chain polypeptide is...
9012372 Method and means for identifying substances which inhibit IgE production  
The invention relates to the field of biomedical and pharmacological research, in particular to the area of immunology, allergies and autoimmune diseases. The inventors have shown that SWAP-70 is...
9012369 Look-through mutagenesis for developing altered polypeptides with enhanced properties  
A method of mutagenesis by which a predetermined amino acid is introduced into each and every position of a selected set of positions in a preselected region (or several different regions) of a...
9012371 Mixtures of binding proteins  
Described are methods for producing libraries of cells expressing at least two separate single polypeptide chain binding proteins, in which the binding proteins have different target epitopes....
9005892 Labelling strategies for the sensitive detection of analytes  
The present invention relates to methods and reagents for detecting analytes, e.g. nucleic acids. The new methods and reagents allow a simple and sensitive detection even in complex biological...
9005670 Use of histone acetyltransferase inhibitors as novel anti-cancer therapies  
The present invention provides methods for treating cancer comprising inhibiting the activity of p300/CBP histone acetyltransferase (HAT). Also provided are p300/CBP HAT inhibitors for treating a...
9005927 Multi-chain eukaryotic display vectors and uses thereof  
A eukaryotic expression vector capable of displaying a multi-chain polypeptide on the surface of a host cell is provided, such that the biological activity of the multi-chain polypeptide is...
9005427 Methods and apparatus for detecting molecular interactions using FET arrays  
Methods and apparatuses relating to large scale FET arrays for analyte detection and measurement are provided. ChemFET (e.g., ISFET) arrays may be fabricated using conventional CMOS processing...
8999894 Nucleic acid-like proteins  
Methods are provided for labeling and for detecting DNA-interacting proteins with an assayable label, comprising combining the DNA-interacting protein with a mfpA pentapeptide repeat family...
8999655 Increase of myeloid microvesicles in the cerebrospinal fluid as biomarker of microglia/macrophage activation in neurological disorders  
The present invention relates to a method for the diagnostic and/or prognostic of a neurological disease characterized by an inflammation process in a subject comprising measuring the amount of...
8993486 Ultra-high throughput screening methods to detect synergistic drug interactions  
Synergy occurs when combined agents induce a response greater than the sum of their individual effects. The present invention provides new high throughput screening methods to detect agents acting...
8969256 Solution microarrays and uses thereof  
The present invention relates to solution microarrays. In particular, the present invention relates to an aqueous 2-phase system for solution microarrays and uses thereof. The present invention...
8969252 Peptide mediated synthesis of metallic and magnetic materials  
The present invention includes methods for producing magnetic nanocrystals by using a biological molecule that has been modified to possess an amino acid oligomer that is capable of specific...
8969255 Compound arrays for sample profiling  
The invention provides arrays of compound for use in profiling samples. The arrays include compounds bind to components of the samples at relatively low affinities. The avidity of compounds...
8969253 Method for screening phage display libraries against each other  
The present invention relates to a method for screening phage display libraries against each other. In particular, the invention relates to a method for screening at least two phage display...
8969254 Oligonucleotide array for tissue typing  
Oligonucleotide-based microarrays for tissue typing (e.g., HLA tissue typing) are provided. More particularly, the microarrays are high resolution arrays useful for diagnostic evaluations and...
8962249 Methods for detecting and treating systemic lupus erythematous  
The invention provides methods and compositions useful for detecting autoimmune disorders.
8962268 Method for determining survival prognosis of patients suffering from non-small cell lung cancer (NSCLC)  
The present invention relates to a method for determining the survival prognosis of patients suffering from non-small cell lung cancer. More specifically, the present invention provides methods...
8962267 Method for predicting the response of non-small cell lung cancer patients to targeted pharmacotherapy  
The present invention relates to a method for determining or predicting the response of a patient diagnosed with non small cell lung cancer to targeted pharmacotherapy. The present invention also...
8957002 DNA microarray having hairpin probes tethered to nanostructured metal surface  
A sensor chip and detection device are disclosed. The sensor chip includes a substrate, at least a portion of which is covered by a metal nanoparticle film; a first nucleic acid molecule that is...
8951938 Combinatorial rosamine library to detect cell-state switching  
The present invention relates to the use of rosamine derivative compounds, as described herein, in detecting differentiated forms of a cell type of interest in a sample and in screening for...
8951939 Digital assays with multiplexed detection of two or more targets in the same optical channel  
System, including methods and apparatus, for performing a digital assay with multiplexed detection of two or more distinct targets in the same optical channel.
8951755 Products comprising inactivated yeasts or moulds and active VHH-type antibodies  
The use of VHHs in the preparation of products to provide stability of antibody specificity under destabilizing conditions whereby normally lower eukaryotes or traditional antibodies are killed or...
8946127 Nucleic acid probe-based diagnostic assays for prokaryotic and eukaryotic organisms  
Use of the ssrA gene or tmRNA, an RNA transcript of the ssrA gene, or fragments thereof as target regions in a nucleic acid probe assay for the detection and identification of prokaryotic and/or...
8932991 Planar support having an ultraflat surface and a device for detecting antigens comprising said planar support  
A nanoarray or microarray of antibodies includes a planar surface having an ultraflat surface, which has a planar substrate functionalized with a first monolayer of linking molecules, preferably...
8932989 Sieving of nucleic acid samples  
A method of selecting nucleic acid samples from a plurality of nucleic acid samples based on desired alleles including the steps of performing a first reaction in a plurality of pools of the...
8932990 Detection of digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, and biliary tract cancer by gene expression profiling  
The present invention provides a method and a reagent for detecting a digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, or biliary tract cancer patient by analyzing...
8927462 Method for identifying HLA complexes associated with adverse drug reactions  
A method for identifying from an HLA library an HLA complex that specifically binds to a compound. This method can be relied on to assess whether a compound is likely to induce an adverse drug...
8927463 Sensitive high throughput method for DNA damage and repair  
A high throughput method and apparatus for rapidly screening a plurality of genotoxicants to determine the degree and type of genotoxicity are provided.
8920723 Sample support structure and methods  
A sample support structure comprising a sample support manufactured from a semiconductor material and having one or more openings therein. Methods of making and using the sample support structure.
8921279 Display of binding agents  
The present invention relates to a method of preparing a genetic package displaying oligomers of modular antibody domains binding to a target and to a scaffold ligand as well as to vectors and...
8921278 Method for the discovery of high-affinity, high specificity oligonucleotide and derivatized oligonucleotide sequences for target recognition  
A method is disclosed to obtain oligonucleotide sequences with high affinity to target molecules. By design, the oligonucleotides have a defined primary and secondary structure. The affinity for...
8921051 Methods and means for typing a sample comprising colorectal cancer cells  
The invention relates to a method of typing colorectal cancer cells by determining the RNA levels of a set of signature genes. Said typing can be use for predicting a risk for recurrence of said...
8916504 Methods of RNA display  
The present invention features improved methods of in vitro RNA display to allow reliable expression and selection of scFv antibody molecules from expression libraries. The improved methods, in...
8912128 Carbohydrate chip for detection of pathogen Vibrio cholerae and method of preparing the same  
The present invention related to a saccharide-based cholera toxin detection sensor for detection of Vibrio cholerae and its use. More specifically, the present invention relates to a carbohydrate...
8906830 Capture agents and related compositions, methods and systems  
The present disclosure relates to capture agents for the detection and/or separation of one or more targets in a sample. Described herein are multi-ligand capture agents comprising two or more...
8906700 Methods and compositions for phototransfer  
Methods are described for phototransferring a compound from a first surface to a second surface. Compounds are described with photocleavable linkers. Compounds attached to a first surface through...
8901044 Method to prepare magnetic beads conjugated with small compounds  
It is an object of the present invention to provide a method for stably and efficiently binding a compound to magnetic beads. The present invention relates to a method for producing compound-bound...