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9006148 Methods using a progressive cavity pump bioreactor  
Methods of using a progressive cavity pump as a bioreactor are disclosed. Methods of isolating a biological product, such as pancreatic islet cells, using the bioreactor are also disclosed.
8912127 Method of generating gene mosaics  
The invention relates to a method for generating a gene mosaic by somatic in vivo recombination, comprising: e) in a single step procedure (vii) transforming a cell with at least one gene A having...
8835162 Methods of incorporating amino acid analogs into proteins  
The invention provides a method of incorporating nonstandard amino acids into a protein by utilizing a modified aminoacyl-tRNA synthetase to charge the nonstandard amino acid to a modified tRNA,...
8759058 Photosynthetic hydrogen production from the green alga chlamydomonas reinhardii  
The present invention relates generally to hydrogen production for use in fuel cells, foodstuffs and chemical production, and more particularly, to biologically and photosynthetically produced...
8741810 In vitro methods of producing and identifying immunoglobulin molecules in eukaryotic cells  
The present invention relates to a high efficiency method of expressing immunoglobulin molecules in eukaryotic cells. The invention is further drawn to a method of producing immunoglobulin heavy...
8525533 Conductivity detector for fluids  
A conductivity detector detects the electrical conductivity of a fluid under analysis for determining chemical or physical properties of the fluid that are related its electrical properties. Such...
8470164 Methods and apparatus for measuring analytes using large scale FET arrays  
Methods and apparatus relating to very large scale FET arrays for analyte measurements. ChemFET (e.g., ISFET) arrays may be fabricated using conventional CMOS processing techniques based on...
8252727 Antibody diversity generation  
Methods for improving antibodies by a variety of DNA diversification and selection procedures are provided. Improvements include increases in affinity, alterations in specificity and effector...
8202823 Structural nucleic acid guided chemical synthesis  
Disclosed is a composition comprising a nucleic acid and a chemical compound, said composition forming a star structure defining 3 or more stems extending from a reaction center. The stems are...
8017559 Combinatorial libraries of proteins having the scaffold structure of C-type lectin-like domains  
The present invention provides novel polypeptides having the scaffold structure of a C-type lectin-like domain (CTLD) and a randomized loop region for specifically binding a variety of target...
7981843 Antibody specificity transfer using minimal essential binding determinants  
The present invention provides methods of making antibodies having the binding specificity of a reference antibody. Antibodies generated by the methods of the inventions have at least one minimal...
7700523 Nucleic acid binding polypeptide library  
The invention relates to a zinc finger polypeptide library in which each polypeptide comprises more than one zinc finger which has been at least partially randomized, and to a set of zinc finger...
7666817 Cellular libraries of peptide sequences (CLiPS) and methods of using the same  
The present invention provides compositions including peptide display scaffolds that present at least one candidate peptide and at least one detectable moiety in at least one of the N-terminal and...
7442160 Evolving new molecular function  
Nature evolves biological molecules such as proteins through iterated rounds of diversification, selection, and amplification. The present invention provides methods, compositions, and systems for...
7361133 Methods of detection utilizing modified bacteriophage  
Viruses expressing ligands on their surfaces are used as a detection means for the related polypeptide which binds the ligand. Multiple copies of the ligand can be expressed on the viral surface....
7291493 Microbially expressed xylanases and their use as feed additives and other uses  
The present invention relates to codon-optimized xylanase coding sequences and the expression of xylanases in microbes and yeast. The invention further relates to using multiple copies of the...
7273741 Copper tolerant yeast and pectinases produced by the yeast  
The object of the present invention is to provide a yeast which is tolerant to copper and which can incorporate copper at a high concentration, and also a method of removing or recovering copper...
7136760 Visualization method of RNA pseudoknot structures  
Disclosed is a visualization method of RNA pseudoknot structures. The method of the invention comprises the steps of setting criteria required for visualizing RNA pseudoknots, setting structural...
7060482 Thermostable xylanases  
The present invention is directed to thermostable xylanase enzymes are suitable for feed pelleting applications. The novel xylanase enzymes comprise at least 40% of their optimal activity from a...
7005260 Tenascin-C nucleic acid ligands  
Methods are described for the identification and preparation of nucleic acid ligands to tenascin-C. Included in the invention are specific RNA ligands to tenascin-C identified by the SELEX method....
6933116 Nucleic acid ligand binding site identification  
This invention comprises nucleic acid ligand for use as a diagnostic reagent for detecting the presence or absence of a target molecule in a sample, and a diagnostic reagent to measure the amount...
6855496 Truncation SELEX method  
This invention is directed to a method for identifying nucleic acid ligands by the SELEX method wherein the participation of fixed sequences is eliminated or minimized.
6808882 Optical sorting method  
The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising the steps of: (a) compartmentalising genetic elements into...
6773900 End selection in directed evolution  
This invention provides methods of obtaining novel polynucleotides and encoded polypeptides by the use of non-stochastic methods of directed evolution (DirectEvolution™). A particular advantage of...
6737236 Bioconjugation of macromolecules  
This invention discloses a novel method for conjugating macromolecules to other molecular entities. Specifically, this invention discloses a method for conjugating or derivatizing macromolecules,...
6730482 Modified SELEX processes without purified protein  
This invention is directed towards a method for obtaining nucleic acid ligands against target proteins without directly purifying the target proteins. The method used in the invention is called...
6727062 Identification of target structures E.G. in vivo selection method for a phage library  
The invention relates to a selection method and the products identified using the selection method which includes the steps of identifying one or more binding structures to a target structure...
6706482 Conditional-selex  
The invention provides method for producing nucleic acid ligands that generate a signal, or cause a decrease in the level of a signal, in the presence of a target molecule or an environmental...
6696245 Methods for selecting functional polypeptides  
The invention provides a method for selecting, from a repertoire of polypeptides, a population of functional polypeptides which bind a target ligand in a first binding site and a generic ligand in...
6686164 Low allergenic protein variants  
The present invention relates to a method of selecting a protein variant having reduced immunogenicity as compared with the parent protein. This method includes the steps of screening a random...
6673553 2′-fluoropyrimidine anti-calf intestinal phosphatase nucleic acid ligands  
Methods are described for the identification and preparation of nucleic acid ligands to calf intestinal phosphatase. Included in the invention are specific RNA ligands to calf intestinal...
6635453 Methods for the enzymatic assembly of polynucleotides and identification of polynucleotides having desired characteristics  
The present invention provides methods of preparing large polynucleotides of arbitrary sequence and in a manner that will readily lend itself to automation. The present invention provides methods...
6613526 Systematic evolution of ligands by exponential enrichment: tissue selex  
This invention discloses high-affinity oligonucleotide ligands to complex tissue targets, specifically nucleic acid ligands having the ability to bind to complex tissue targets, and the methods...
6576467 Methods for producing recombined antibodies  
A method for DNA reassembly after random fragmentation, and its application to mutagenesis of nucleic acid sequences by in vitro or in vivo recombination is described. In particular, a method for...
6573072 Ribozymes having 2′-O substituted nucleotides in the flanking sequences  
The present invention provides methods for increasing ribozyme catalytic activity without reducing specificity, which methods comprise contacting an RNA molecule with a ribozyme having a flanking...
6506566 Phage display for detergent enzyme activity  
The invention relates to a method of identifying enzymes suitable for use in detergents, especially the selection of specific enzyme variants among a large number of such variants created through...
6506603 Shuffling polynucleotides by incomplete extension  
A method for DNA reassembly after random fragmentation, and its application to mutagenesis of nucleic acid sequences by in vitro or in vivo recombination is described. In particular, a method for...
6500617 Optimization of pest resistance genes using DNA shuffling  
This invention provides methods of obtaining pest resistance genes that are improved over naturally occurring genes for use in conferring upon plants resistance to pests. The methods involve the...
6500639 DNA shuffling to produce nucleic acids for mycotoxin detoxification  
Methods of shuffling nucleic acids to acquire or enhance mycotoxin detoxification activity, libraries of shuffled mycotoxin detoxification nucleic acids, transgenic cells, plants and DNA shuffling...
6489145 Method of DNA shuffling  
Disclosed is a method of producing random polynucleotides by introducing two or more related polynucleotides into a suitable host cell such that a hybrid polynucleotide is generated by...
6479258 Non-stochastic generation of genetic vaccines  
This invention provides methods of obtaining vaccines by use of non-stochastic methods of directed evolution (DirectEvolution™). These methods include non-stochastic polynucleotide...
6465192 Compounds and methods for the inhibition of protein-protein interactions  
Compounds having molecular weights of less than 1500 daltons that non-covalently interact with target proteins and covalently bond to target proteins at amino acid side chains that are not part of...
6440668 Method of DNA shuffling with polynucleotides produced by blocking or interrupting a synthesis or amplification process  
Disclosed is a process of performing Sexual PCR which includes generating random polynucleotides by interrupting or blocking synthesis or amplification process to slow or halt synthesis or...
6365408 Methods of evolving a polynucleotides by mutagenesis and recombination  
A method of mutating a polynucleotide such that it has a desired or improved functional property is disclosed.
6361949 Nucleic acid amplification with direct sequencing  
This invention provides methods of amplifying a sequence of interest present within a nucleic acid molecule. In addition, this invention provides a method of determining the nucleotide sequence of...
6352842 Exonucease-mediated gene assembly in directed evolution  
A directed evolution process comprising novel methods for generating improved progeny molecules having desirable properties, including, for example, a method for rapid and facilitated production...
6344356 Methods for recombining nucleic acids  
A method for DNA reassembly after random fragmentation, and its application to mutagenesis of nucleic acid sequences by in vitro or in vivo recombination is described. In particular, a method for...
6132970 Methods of shuffling polynucleotides  
The invention is directed to methods of shuffling polynucleotide variants. The methods entail conducting a multi-cyclic polynucleotide extension process on partially annealed polynucleotide...
6022691 Determination of oligonucleotides for therapeutics, diagnostics and research reagents  
Oligonucleotides which selectively bind to target biomolecules are determined by in vitro assay of a pool of random oligonucleotides for activity against the biomolecules, followed by recovery and...
5856085 Compositions and methods of developing oligonucleotides and oligonucleotide analogs having antiviral activity  
Methods of identifying and preparing anti-infectious agent compounds comprising the steps of incubating single stranded nucleic acids or nucleic acid analogs in the presence of infectious agents,...
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