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8889102 |
Neuromyelitis optica autoantibodies as a marker for neoplasia
The present invention provides for methods and materials for diagnosing and treating neuromyelitis optica (NMO). |
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8822233 |
Ultra-sensitive chemiluminescent substrates for enzymes and their conjugates
New chemiluminescent compounds, stable in aqueous buffers, for use in biological assaying include acridane-based compounds and 1,2-dioxetanes. Among the new acridane-based compounds are... |
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8785212 |
Oligosaccharide modification and labeling of proteins
The present invention generally relates to methods of functionalizing proteins, particularly antibodies, at oligosaccharide linkages, methods of humanizing antibodies by modifying glycosylation,... |
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8735178 |
Withanolides, probes and binding targets and methods of use thereof
Novel withanolide chemical genetic probes identify the in vivo binding target of withaferin A, which is the intermediate filament type III protein vimentin. In addition, a withanolide-based small... |
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8642357 |
Semaphorin 7A plays a critical role in TGF-β1-induced pulmonary fibrosis and alveolar destruction
The present invention provides methods of treating a subject diagnosed with, or at risk for developing, pathogenic fibrosis, particularly pulmonary fibrosis. The method of the invention comprises... |
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8614103 |
Compositions and methods for treating sphingosine-1-phosphate (S1P) related ocular diseases and conditions
The present invention relates to compositions and methods for prevention and treatment of diseases and conditions, particularly ocular diseases and conditions, characterized by aberrant... |
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8546095 |
Methods for determination of calcineurin activity and uses in predicting therapeutic outcomes
The methods of the disclosure provide fluorescence-based assays for calcineurin activity, especially in isolated T cells. The methods include the stimulation of the T cells with agents that... |
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8524508 |
Methods of treating neuromyelitis optica (NMO)
The present invention provides for methods and materials for diagnosing and treating neuromyelitis optica (NMO). |
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8501498 |
Mass tags for quantitative analyses
This invention pertains to methods, mixtures, kits and/or compositions for the determination of analytes by mass analysis using unique labeling reagents or sets of unique labeling reagents. The... |
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8486401 |
Monoclonal antibodies binding to TrkA and acting as NGF-antagonist molecules and their use for treating pain induced by NGF
Monoclonal antibodies, synthetic and biotechnological derivatives thereof (ScFv or others) are able to recognise the NGF high affinity receptor, TrkA, and act as NGF-antagonist molecules.... |
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8334104 |
Methods for detection of hydrophobic drugs
Methods and reagents are disclosed for pretreating a sample suspected of containing a hydrophobic drug for conducting an assay method for detecting the hydrophobic drug. A combination is provided... |
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8067247 |
Use of anti-CD100 antibodies for the treatment of inflammatory disorders affecting the central or peripheral nervous system
The invention relates to the use a BD16 and/or BB18 anti-CD100 antibody or of a chimeric or humanized or human form thereof, or a fragment thereof, for the therapy or diagnosis of a central... |
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7811828 |
Method for identifying and quantifying of tumuor-associated
Described is a method for identifying and quantifying of tumour-associated peptides, wherein first at least two different sources for obtaining the peptide are provided (tumourous and healthy... |
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7781229 |
Ultra-sensitive chemiluminescent substrates for enzymes and their conjugates
New chemiluminescent compounds, stable in aqueous buffers, for use in biological assaying include acridanebased compounds and (1,2)-dioxetanes. Among the new acridanebased compounds are... |
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7776612 |
Method of quantifying antigen expression
The present invention is directed to a novel method for quantifying antigen, such as the amount expressed on a cell. The method comprises formulating an equation of correlation between the amount... |
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7736911 |
Activity-based probes for protein tyrosine phosphatases
Provided are compounds capable of covalently binding to a protein tyrosine phosphatase (PTP). The compounds comprise Formula A: Also provided are compositions comprising one of the above compounds... |
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7591953 |
Methods and apparatus for continuous large-scale radiolabeling of proteins
Disclosed are improved methods and apparatus for radiolabeling, particularly methods and apparatus for large scale in-line radiolabeling of products, such as proteins and antibodies. |
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7357915 |
Method of imaging cell death in vivo
A method of imaging apoptosis in vivo, using radiolabeled annexin, is described. |
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7342091 |
Soluble cyclic analogues of β amyloid peptide
The invention concerns a peptide having the biological activity of an inhibitor of amyloid formation and its diagnostic and medical use. |
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7332355 |
Method and compositions for the detection of protein glycosylation
The invention provides methods and compositions for the rapid and sensitive detection of post-translationally modified proteins, and particularly of those with post-translational glycosylations.... |
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7291714 |
Glycoprotein VI and uses thereof
The invention provides isolated nucleic acid molecules and polypeptide molecules that encode glycoprotein VI, a platelet membrane glycoprotein that is involved platelet-collagen interactions. The... |
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7291476 |
O-acetyltranferases
A post-translational modification of a predetermined protein expressed by a cell is detected by specifically detecting an O-acetylation of a serine, threonine or tyrosine residue of the protein as... |
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7235370 |
Site-specific aminoglycoside derivatives for use in immunodiagnostic assays
A method of making a derivatized aminoglycoside includes reacting an aminoglycoside with at least 2 equivalents of a divalent metal ion in an aprotic solvent to complex two neighboring amino group... |
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7229782 |
Antibodies specific to multiple beta blockers and methods for their use
The present invention is directed antibodies specific to multiple beta blockers, as well as immunogens used to produce the antibodies and immunoassay kits and methods for using the antibodies. |
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7205162 |
Artificial antibodies, method of producing the same and use thereof
Artificial antibodies or antibody mimics are described. They consist of polymers that carry specific binding sites mimicking the properties of antibodies. There is also described a method for... |
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7195882 |
Monoclonal antibodies specific for buprenorphine and metabolites thereof
The present invention relates to monoclonal antibodies that specifically bind buprenorphine and/or at least one metabolic product thereof. The present invention further relates to buprenorphine... |
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7186518 |
Method and composition useful for determining FK 506
New derivatives of FK 506 are disclosed. These new derivatives and other derivatives that are useful for determining the levels of FK 506 in a sample are also provided as are assay procedures and... |
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7169907 |
Derivatives, immunogens, and antibodies for detecting ecstasy-class drugs
Compounds including haptens, intermediates, and immunogens that are useful in the production of antibodies specific for the methylenedioxy class of amphetamine derivatives are described.... |
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7132513 |
Bifunctional chelating agent
The invention concerns a ligand comprising wherein n is an integer from 1 to 5, X represents —NO2, —NH2, —NCS, —NHCOCH2-Z. NHCO—W—COCNHS, —NH-Q, —NHCS-Q, —NHCOCH2-Q, or —NHCO(CH2)m ?-Q where Q is... |
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7132269 |
Coupling agents, the active intermediates and the conjugates thereof and the use of said conjugates in diagnostic methods
The present invention concerns coupling agents having the following general formula: activated intermediates consisting of a coupling agent such as defined above with either a molecule having on... |
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7115718 |
Haptens, immunogens, antibodies and conjugates to 2-oxo-3-hydroxy-LSD
The invention provides a hapten derivatized with a crosslinker at the nitrogen of the 8β-carboxamide of 2-oxo-3-hydroxy LSD. The invention also provides an immunogen comprising the aforementioned... |
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7108985 |
Methods and kits useful for the simplification of complex peptide mixtures
Methods and reagents for obtaining simplified mixtures of peptides from a sample containing a number of peptides are disclosed. The simplified sample can be easier to analyze than the original... |
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7109310 |
Method and kit for detecting, or determining the quantity of, metabolites of fentanyl and metabolites of fentanyl analogs
The invention provides an immunogen comprising a hapten coupled to an antigenicity-conferring carrier material, a conjugate comprising the aforementioned hapten coupled to a labelling agent, as... |
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7101719 |
Support and method for cell based assays
Disclosed is a method for the measurement of a cellular process, or for the measurement of the effect of a test compound on a cellular process, in one or more different populations of cells. The... |
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7101980 |
Derivatives, conjugates, and antibodies for detecting ecstasy-class analytes
Compounds including haptens, intermediates, and immunogens that are useful in the production of antibodies specific for the methylenedioxy class of amphetamine derivatives are described.... |
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7078495 |
Monoclonal antibodies to tacrolimus and immunoassay methods for tacrolimus
An IgG1 λ monoclonal antibody to the immunosuppressive drug tacrolimus has improved properties. In particular, this monoclonal antibody, designated 1H6, has reduced cross-reactivity to several... |
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7070941 |
Methods and compositions for tagging via azido substrates
The invention provides methods and compositions for azide tagging of biomolecules. In one embodiment of the invention, proteins are tagged by metabolic incorporation of prenylated azido-analog... |
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7052915 |
Selective labeling and isolation of phosphopeptides and applications to proteome analysis
A method for selective labeling of phosphate groups in natural and synthetic oligomers and polymers in the presence of chemically related groups such as carboxylic acid groups. The method is... |
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7045309 |
9-substituted adenine derivatives as prodrug regulators of cell and tissue function
The present invention relates to 9-substituted adenine derivatives represented by formula (I) wherein W is selected from the group consisting of H, halogen, azido and amino group; X is selected... |
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7045310 |
Redox reversible bipyridyl-osmium complex conjugates
Novel bipyridyl-osmium complex conjugates and their use in electrochemical assays are described. The redox reversible-osmium complexes can be prepared to exhibit unique reversible redox potentials... |
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7045606 |
Bifunctional chelating agent for actinium
The invention concerns a ligand comprising (I) wherein n is an integer from 1 to 5 Y is CO2H or PO3H2T represents —X or -phenyl-X, wherein X represents NO2, NH2, NCS, NHCOCH2-Z, NHCO—W—COCNHS,... |
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6964872 |
Immunoassay method
When insoluble magnetic carrier particles are used in immunoassay, a method is provided which is suitable for saving labor and for treating a large number of samples within a short time while... |
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6946547 |
Ecstasy-class analogs and use of same in detection of ecstasy-class compounds
The present invention provides a system for the improved detection of ecstasy-class compounds in biological samples. New ecstasy-class analogs are provided for detection of such ecstasy-class... |
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6921669 |
Linker system for activating surfaces for bioconjugation
The present invention relates to a linker system for activating surfaces for bioconjugation, and particularly to a linker system having a novel hydrophilic spacer group. The inventive linker... |
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6913936 |
Immunological test kit comprising an immunologically invisible peg copolymer conjugated to one or more immunologically reactive substances
A novel compound comprising an immunologically invisible polyethylene glycol copolymer is used to carry one or more immunologically reactive substances. The novel compounds may be used as part of... |
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6905886 |
Preservative solutions
This invention relates to preservative solutions for peptides, for example, parathyroid hormone, insulin-like growth factor binding protein 3 (IGFBP3), adrenocorticotropic hormone (ACTH) and... |
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6844162 |
Assays for TSH receptor autoantibodies
A method and kit for monitoring autoantibodies to thyroid stimulating hormone (TSH) receptor in a sample of body fluid, which employs the steps of: (i) incubating TSH receptor with a sample of... |
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6844166 |
Recombinant reduced valency carbohydrate binding ligands
The invention is based on the discovery of reduced valency carbohydrate binding ligands (CBLs) that can be used to to detect or quantitate (i.e., evaluate) carbohydrates in a sample. CBLs can be... |
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6787325 |
Complexes containing crosslinked avidin, analytical method with the use of crosslinked avidin and analytical reagents and kits
Provided are novel complexes containing a crosslinked avidin, an analyzing method and analyzing reagents and kits whereby a compound to be analyzed can be quickly, conveniently and accurately... |
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6773928 |
Compositions and methods for enhancing bioassay performance
Compositions of matter and methods for enhancing bioassay performance are disclosed. More particularly, the composition of matter comprises a molecularly compact polymer-ligand conjugate capable... |