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9029097 Biosensors for monitoring receptor-mediated G-protein activation  
The present invention relates to novel biosensors that are based on bioluminescence resonance energy transfer (BRET). These biosensors may be used to monitor rapid interaction and conformational...
9012164 Bioluminescent assays utilising secreted luciferases  
Disclosed herein are methods for determining the amount or activity of one or more luciferases and methods for measuring the luminescent signal generated by one or more luciferases in a sample,...
8999896 Discovery and applications of the proteolytic function of N-terminal acetylation of cellular proteins  
Screening assays that allow for the identification of agents that modulate the activity of N-terminal acetylation of a polypeptide and the Doa10 branch of the N-end rule pathway are provided. Also...
8986940 Detecting infection in reduced pressure wound treatment  
Provided is a method of detecting infection in a wound caused by an infecting organism at a wound site. Also provided is a system for detecting an infection in a wound at a wound site....
8975293 Epigenetic co-repressors of the gamma-globin gene and methods of using same  
This disclosure describes methods of screening for compounds that disrupt the interaction between DNMT1 and the gamma-globin promoter or between LSD-1 and the gamma-globin promoter. This...
8951745 Compositions for diagnosis and therapy of diseases associated with aberrant expression of futrins (R-Spondins) and/or Wnt  
The present invention relates to a composition useful for the diagnosis of diseases associated with aberrant expression of the genes encoding the secreted proteins Futrin 1, 2, 3 and/or 4...
8945862 Triple-fusion constructs and methods of monitoring human embryonic stem cells  
Embodiments of the present disclosure include triple-fusion human embryonic stem cells, methods of imaging triple-fusion human embryonic stem cells, triple-fusion polynucleotides, triple-fusion...
8937183 Detection of hydrogen peroxide  
The present invention provides compounds useful for detection of hydrogen peroxide and methods of using same.
8932818 Screening assays for compounds that modulate programmed ribosomal frameshifting  
The present invention relates to compounds that modulate ribosomal frameshifting and nucleic acid constructs for use in methods for identifying or validation of compounds that modulate ribosomal...
8921056 Compositions for diagnosis and therapy of diseases associated with aberrant expression of futrins (R-Spondins) and/or Wnt  
The present invention relates to a composition useful for the diagnosis of diseases associated with aberrant expression of the genes encoding the secreted proteins Futrin 1, 2, 3 and/or...
8916347 Integrated microfluidic and solid state pyrosequencing systems  
The invention provides for sequencing a nucleic acid molecule based on the detection of base incorporation by the release of pyrophosphate (PPi) using a new enzyme system comprising adenosine...
8916608 ***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
Epigenetic co-repressors of the gamma-globin gene and methods of using same
 
This disclosure describes methods of screening for compounds that disrupt the interaction between DNMT1 and the gamma-globin promoter or between LSD-1 and the gamma-globin promoter. This...
8900817 Progastrin and liver pathologies  
Progastrin levels are determined to diagnose one or more liver pathologies.
8877434 Method and system of detecting dioxin-like compounds  
The invention relates to a method or a cell free system of detecting dioxin-like compounds in a test sample using a whole cell lysate derived from a cell transfected to express a fusion protein...
8859220 Luciferase-based assays  
A method and kit are provided for enhancing the tolerance of an assay reagent to compounds in an assay sample, the assay reagent including a luciferase enzyme. The method includes contacting the...
8846327 Method of quantifying autoinducer-2  
A method of quantifying autoinducer-2, including the steps of: preparing a calibration curve using 4-hydroxy-5-methyl-3(2H)-furanone as a standard sample; andquantifying autoinducer-2 in a test...
8841129 Method for monitoring inhibition of platelet function  
The invention provides a method of monitoring the response of platelets to a cyclooxygenase-1 (COX1) inhibitor such as aspirin. The method involves collecting platelet-containing mammalian blood...
8822170 Thermostable luciferases and methods of production  
Luciferase enzymes with greatly increased thermostability, e.g., at least half lives of 2 hours at 50° C., cDNAs encoding the novel luciferases, and hosts transformed to express the luciferases,...
8802365 Methods for identifying candidate modulators of NOTUM activity  
The invention provides compositions and methods of use for identifying modulators of NOTUM, e.g., NOTUM inhibitors. In some aspects, identified compounds are useful for modulating Wnt signaling at...
8795977 Method for screening a potential modulator compound of a taste receptor  
A method for screening a potential modulator compound of a taste receptor wherein use is made of a BRET technique.
8785652 Detection of hydrogen peroxide  
The present invention provides compounds useful for detection of hydrogen peroxide and methods of using same.
8771935 Screening methods for cognitive enhancers  
The present invention provides methods for identifying cognitive enhancers able to enhance CREB pathway function. Cognitive enhancers identified in accordance with the invention can be used in...
8735062 Chemiluminescence proximity nucleic acid assay  
This invention relates to the detection and quantitation of target nucleic acids in a heterogeneous mixture in a sample and the methods of use thereof. The detection system includes a...
8722338 Modulation of ABCG2-mediated urate transport to treat hyperuricemia and gout  
Genome-wide association studies (GWAS) was recently used to identify SNPs in a genomic region on chromosome 4 that associate with serum urate levels and gout. The present disclosure shows that...
8715950 Kits for luminogenic and nonluminogenic multiplex assays  
Methods and kits to detect the presence or amount of at least one molecule for an enzyme-mediated reaction in a multiplex luminogenic/nonluminogenic assay are provided.
8703413 Detection of human somatic cell reprogramming  
The methods and kits described herein are based, in part, to the discovery phenotype representing a fully-reprogrammed iPS cell and several reprogramming intermediates. The methods and kits...
8697356 Single-molecule-format probe and utilization thereof  
A single-chain probe of the present invention for detecting a ligand, comprises: a ligand binding protein for binding the ligand; a recognition protein for recognizing that the ligand is bound by...
8673558 Luciferase biosensor  
A modified beetle luciferase protein which is an environmentally sensitive reporter protein is provided.
8652794 Mutant luciferase  
An isolated recombinant luciferase having luciferase activity. The recombinant luciferase has an amino acid sequence which differs from the wild-type luciferase from Photinus pyralis, Luciola...
8642257 Vaccinia virus for diagnosis and therapy of tumors  
Described are diagnostic and pharmaceutical compositions comprising a microorganism or cell containing a DNA sequence encoding a detectable protein or a protein capable of inducing a detectable...
8642272 Isolated luciferase gene of L. italica  
The present invention relates to an isolated nucleic acid and polypeptide sequence that encodes for a luciferase of Luciola italica, as well as mutants thereof. The luciferase proteins of the...
8637267 Antibacterial and plasmid elimination agents  
Inhibitors of the tmRNA pathway have antibacterial activity with broad species specificity, including B. anthracis and other pathogens of military and civilian interest. Identified cyclic or...
8609342 Reporter gene assay method  
The invention provides a reporter gene assay method by which the sex hormone-like activity inherent in a test substance can be accurately assayed excluding the effects caused by a decrease in cell...
8603767 Luciferase-based assays  
A method and kit are provided for enhancing the tolerance of an assay reagent to compounds in an assay sample, the assay reagent including a luciferase enzyme. The method includes contacting the...
8592172 Bioluminescent assays using cyanobenzothiazole compounds  
The invention provides methods that employ derivatives of 2-cyano-6-hydroxy- or 2-cyano-6-amino-benzothiazole, for example, in a bioluminogenic reaction. The invention further provides methods for...
8586022 Light emitting microorganisms and cells for diagnosis and therapy of tumors  
Provided are diagnostic and pharmaceutical compositions containing a microorganism or a cell containing a DNA molecule encoding a detectable protein or a protein that a detectable signal, such as...
8569002 Multiplexed luciferase reporter assay systems  
Inhibitors of luciferase enzymes are disclosed and find use in multiplexed assays using multiple luciferases and multiple inhibitors, in both in vitro and in vivo embodiments.
8569003 Fusion protein having luminescence activity  
The fusion protein comprising (1) a first region comprising the amino acid sequence of SEQ ID NO: 18 and (2) a second region comprising an amino acid sequence for a polypeptide containing at least...
8568707 Light emitting microorganisms and cells for diagnosis and therapy of tumors  
Provided are diagnostic and pharmaceutical compositions containing a microorganism or a cell containing a DNA molecule encoding a detectable protein or a protein that a detectable signal, such as...
8558004 Reagents and kits for detection of influenza virus and the like  
The present invention relates to reagents and methods for influenza virus detection. These reagents and methods disclosed in the present invention enable simple, rapid, specific and sensitive...
8551718 Functional assay for 5-HT2A, histamine H1 or adrenergic alpha 1B receptors  
The present invention provides novel functional assay for 5-HT2A, histamine H1 or adrenergic alpha 1b receptors, by measuring intracellular cyclic adenosine monophosphate (cAMP) levels utilizing...
8551721 Bioluminescent detection of cyanohydroxy benzothiazole compounds  
The invention provides methods that employ derivatives of 2-cyano-6-hydroxy- or 2-cyano-6-amino-benzothiazole, for example, in a bioluminogenic reaction. Also provided are novel compounds that can...
8546147 Imidazo[1,2-α]pyrazin-3(7H)-one derivatives bearing a new electron-rich structure  
The present invention relates to compound of formula I: and their use as chemiluminescent and/or bioluminescent reagents.
8518658 ATP-bioluminescence immunoassay  
Disclosed is a method and associated device for the rapid identification of viable bacterial contaminants in food products. The method detects viable microbes by using a combined...
8512968 Methods, reagents and kits for luciferase assay  
The invention relates to methods, reagents and kits for detecting enzyme activity using bioluminescence. In particular, it relates to a novel luciferase assay system with reduced background...
8501428 Single molecule detection platform, manufacturing method thereof and method using the same  
A single molecule detection platform is disclosed. The single molecule detection platform comprises a light-transmissive substrate, a plurality of spherical particles and a thin film. The surface...
8460892 Detecting infection in reduced pressure wound treatment  
Provided is a method of detecting infection in a wound caused by an infecting organism at a wound site. Also provided is a system for detecting an infection in a wound at a wound site....
8450054 Modified Luciola cruciata luciferase gene and protein  
A codon optimized and stabilized luciferase gene based upon the sequence of the natural luciferase gene isolated from Luciola cruciata (Japanese firefly) and a novel recombinant DNA characterized...
8445412 Separation of pyrophosphate release and pyrophosphate detection  
The present technology relates to methods and systems for detection of pyrophosphate. As such, disclosed herein are methods and systems that permit improved pyrophosphate detection. Also disclosed...
8431698 Bioluminescent endoscopy methods and compounds  
Bioluminescent endoscopy methods and compounds, wherein an anatomical object is examined by means of filling, perfusing, intubating, injecting, or otherwise administering a solution containing a...

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