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8993268 Method of producing Clostridium botulinum toxin using media containing plant-derived components and flexible closed container  
Provided are a method of producing Clostridium botulinum toxin by using a media containing plant-derived components, and a method of producing Clostridium botulinum toxin by using a flexible...
8932827 Process and system for obtaining botulinum neurotoxin  
Rapid, animal protein free, chromatographic processes and systems for obtaining high potency, high yield botulinum neurotoxin for research, therapeutic and cosmetic use.
8927229 Process and system for obtaining botulinum neurotoxin  
Rapid, animal protein free, chromatographic processes and systems for obtaining high potency, high yield botulinum neurotoxin for research, therapeutic and cosmetic use.
8859235 Methods in cell cultures, and related inventions, employing certain additives  
A method for the manufacture of products by biotechnological methods in bacterial cell culture is disclosed as well as products obtained, the use of certain additives to the media used in the...
8822762 Bacillus thuringiensis gene with lepidopteran activity  
The invention provides nucleic acids, and variants and fragments thereof, obtained from strains of Bacillus thuringiensis encoding polypeptides having pesticidal activity against insect pests,...
8796216 Suppression of neuroendocrine diseases  
The present invention relates to a method for suppressing neuroendocrine disease. The therapy employs use of a non-cytotoxic protease, which is targeted to a neuroendocrine tumor cell, preferably...
8771990 Method of producing lipidated polypeptides  
A method of producing a recombinant lipidated polypeptide in E. coli. The method includes providing an E. coli host cell adapted to express a recombinant lipidated polypeptide; and culturing the...
8735097 Human antibiotic proteins  
The invention relates to proteins, notably SAP-2 and SAP-3, having an antibiotic action. The invention also relates to a method for purifying certain antimicrobial proteins, as well as to a use of...
8686124 AXMI223z delta-endotoxin gene and methods for use  
Compositions and methods for conferring pesticidal activity, including against lepidopteran pests, to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a...
8586832 Bacillus thuringiensis gene with Lepidopteran activity  
The invention provides nucleic acids, and variants and fragments thereof, obtained from strains of Bacillus thuringiensis encoding polypeptides having pesticidal activity against insect pests,...
8586331 Process for the production of the Actinobacillus pleuropneumoniae toxin ApxI employing a culture medium comprising calcium-borogluconate complex  
The present invention pertains to a method to produce RTX-toxin Apxl by culturing Actinobacillus pleuropneumoniae bacteria in a liquid culturing medium that supports growth of the bacteria, to...
8557548 Compositions relating to a mutant Clostridium difficile toxin and methods thereof  
In one aspect, the invention relates to an immunogenic composition that includes a mutant Clostridium difficile toxin A and/or a mutant Clostridium difficile toxin B. Each mutant toxin includes a...
8492120 Process for preparing human G-CSF  
The present invention discloses an improved process for the production of G-CSF in high yield via a high salt-induced increase in plasmid stability during the production phase.
8445235 Process for the production of the Actinobacillus pleuropneumoniae toxins APXI or APXIII in a liquid culture medium under supply of air enriched in carbon dioxide  
The current invention pertains to a method to produce RTX-toxins ApxI or ApxIII by culturing Actinobacillus pleuropneumoniae bacteria in a liquid culturing medium that supports growth of the...
8357365 Granulysin peptides and methods of use thereof  
Granulysin peptides are small antimicrobial agents with potent activity. A pharmaceutical composition comprising granulysin peptides as an active agent is administered therapeutically to a patient...
8148102 Sequences for FK228 biosynthesis and methods of synthesizing FK228 and FK228 analogs  
Polynucleotides encoding the polypeptides involved in biosynthesis of FK 228 and those involved in synthesis of a novel FK228 analog, thailandepsin are disclosed herein. Also provided are methods...
8129139 Process for obtaining botulinum neurotoxin  
Rapid, animal protein free, chromatographic processes and systems for obtaining high potency, high yield botulinum neurotoxin for research, therapeutic and cosmetic use.
8119371 Process for the preparation of polymyxin B employing (PAENI) Bacillus polymyxa  
The invention is related to the process of fermentation with production strain Bacillus polymyxa for industrial production of antibiotic polymyxin B with yield from 1.8 to 2.8 g/l of filtrate of...
8110549 Alpha-conotoxin peptides  
The invention relates to relatively short peptides (termed α-conotoxins herein), about 10-30 residues in length, which are naturally available in minute amounts in the venom of the cone snails or...
8101573 α-conotoxin MII analogs  
The invention relates to novel conopeptides and/or novel uses of conopeptides. The conopeptides of the invention are analogs of α-Conotoxin MII that are selective for α6-containing nAChRs as...
8021862 Process for preparing human G-CSF  
The present invention discloses an improved process for the production of G-CSF in high yield via a high salt-induced increase in plasmid stability during the production phase.
8003348 Method for the mass expression of an antimicrobial peptide by co-expression of a basic antimicrobial peptide and an acidic peptide using a translational coupling system  
The present invention relates to a gene construct which is capable of achieving efficient production of an antimicrobial peptide in a microorganism, and a method for efficient mass production and...
7939081 Method for producing cercosporamide  
The present invention provides a process for producing cercosporamide comprising culturing a fungus belonging to the genus Lachnum and/or fungus belonging to the genus Pseudaegerita and recovering...
7935503 Methods for producing and using polymyxins  
The present invention provides methods for producing a polymyxin from an isolated Paenibacillus amylolyticus, and methods for using the polymyxin, including methods for producing a recombinant...
7927836 Device and method for the production of biologically active compounds by fermentation  
The present invention relates to a process and an apparatus for the fermentational production of biologically active materials, wherein a fermenter is located in an insulator which, in turn, is...
7855059 Fermentation with cyclic pulse-pause feeding  
A process for the production of a valuable compound, comprising the steps of a) fermentation of a filamentous bacterial or fungal strain (e.g. a Streptomyces strain or an Aspergillus strain) in a...
7846435 Humanized antibodies that recognize Verotoxin II and cell line producing same  
The invention provides humanized antibodies that specifically bind to, and preferably, neutralize, verotoxin II (VT2). The antibodies are useful for treating patients suffering from, or at risk of...
7833524 Method of preparing botulinum neurotoxin type E light chain  
The present invention provides a preparation of botulinum toxin light chain type A or E, wherein the preparation is both catalytically active and soluble. Preferably, the preparation consists...
7829321 Method for the production of bacterial toxins  
Methods and compositions are provided for the enhanced production of bacterial toxins in large-scale cultures. Specifically, methods and compositions for reducing bacterial toxin expression...
7820411 Escherichia coli-derived vaccine and therapy against botulism  
A method of producing botulinum toxin C-terminal receptor binding domain (HCR) is disclosed. The one embodiment, the method comprises the steps of (a) preparing E. coli transformed with an...
7811598 AXMI-028 and AXMI-029, a family of novel delta-endotoxin genes and methods for their use  
Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for a delta-endotoxin...
7803391 AXMI-028 and AXMI-029, a family of novel delta-endotoxin genes and methods for their use  
Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for a delta-endotoxin...
7771972 Gene cluster of pederin biosynthesis genes  
The present invention relates to the cloning, sequencing and analysing of a gene cluster encoding a modular polyketide synthase enzyme involved in the biosynthesis of the antitumor compound...
7745175 Polynucleotides encoding Clostridium perfringens alpha toxin proteins  
This invention pertains in part to the development of a vaccine for poultry against necrotic enteritis (NE). The vaccine utilizes a protective antigen that is a mutated, full-length, non-toxic...
7666631 Adenosylmethionine synthetase from streptomyces sp., gene sequences coding the same and method for mass production of secondary metabolites including antibiotics thereof  
Disclosed is an isolated nucleotide sequence encoding an enzyme catalyzing biosynthesis of SAM (SAM-s) and its amino acid sequence. Also, the present invention provides a method for mass...
7582291 Bacteriophage lysins for Enterococcus faecalis, Enterococcus faecium and other bacteria  
The present disclosure relates to bacteriophage lysins useful for the reduction of certain bacterial populations, including methods and compositions for the treatment of various bacterial...
7553832 Methods and compositions for specific inhibition of protein splicing by small molecules  
The present invention relates to compositions (i.e., various organic small molecules as exemplified herein) and methods for the inhibition of protein splicing and especially relates to the...
7517667 Methods for promoting, inhibiting and detecting toxin entry into cells  
In vitro delivery of the diphtheria toxin (DT) catalytic (C) domain from the lumen of purified early endosomes to the external milieu requires the addition of both ATP and a cytosolic...
7465443 Acellular antibordetella vaccine  
The invention relates to an immunogenic composition, characterized in that it comprises an adenyl cyclase-hemolysin (AC-Hly) protein, or an immunogenic portion of this AC-Hly, of a strain of...
7449311 Method of producing macedocin by culturing Streptococcus macedonicus  
The invention relates to the field of bacteriocin producing microorganisms. The invention more specifically relates to the characterization of a novel food grade bacteriocin, namely a lantibiotic,...
7446094 Cytotoxic depsipeptides  
Compounds of general formula (I) wherein R1, R2, R3 are as defined and R4 groups are each independently selected from NR2, O and S; are of use in treatment of cancers.
7432080 Process for the production of teicoplanin  
The present invention provides a newly isolated mutant culture of Actinoplanes teichomyceticus BNG 2315. This culture is capable of producing teicoplanin more than 60 times productivity than those...
7407654 Antibiotics GE 81112 factors A,B,B1, pharmaceutically acceptable salts and compositions, and use thereof  
The invention relates to an antibiotic substances of microbial origin, arbitrarily denominated antibiotic GE 81112 factor A, factor B1 and factor B, which is produced by fermentation of...
7396665 Method of producing FR901228  
Depsipeptides and congeners thereof are disclosed having structure (I), wherein m, n, p, q, X, R1, R2 and R3 are as defined herein. These compounds, including FR901228, have activity as, for...
7378257 Bacterial superantigen vaccines  
The present invention relates to genetically attenuated superantigen toxin vaccines altered such that superantigen attributes are absent, however the superantigen is effectively recognized and an...
7335495 Process for the isolation of pharmaceutical compound cyclosporin a from fungus fusarium nivale  
The present invention describes the development and standardization of a facile method for the isolation and purification of cyclosporin A from a new source, viz., Fusarium nivale and evaluation...
7326782 Metabolic engineering of viomycin biosynthesis  
The invention provides a nucleic acid molecule comprising at least a functional fragment of the viomycin biosynthetic gene cluster, functional proteins encoded by the cluster, expression cassettes...
7326689 Pseudomycins useful against plant diseases  
Plants and crops subject to attack by fungal related diseases are protected or treated by the application of Pseudomycin compositions which were originally isolated from Pseudomonas syringae.
7312080 Plant resistance to insect pests mediated by viral proteins  
The invention involves combining a peptide toxin effective against insects, including but not limited to thrips, leaf hoppers, and beetles, with a transport peptide capable of facilitating...
7241614 Methods for producing polypeptides in Aspergillus mutant cells  
The present invention relates to methods for producing a polypeptide of interest by (a) cultivating a mutant of a parent Aspergillus cell, wherein (i) the mutant comprises a first nucleic acid...

Matches 1 - 50 out of 365 1 2 3 4 5 6 7 8 >