Matches 1 - 50 out of 79 1 2 >


Match Document Document Title
8470562 IRX-2 modified manufacturing process  
A highly efficient method of making a primary cell derived biologic by purifying mononuclear cells (MNCs) in a automated cell processor to remove contaminating cells by loading leukocytes onto...
6913924 Population of interferon producing cells  
Dendritic cell subsets, and various methods of making and using same are provided. In particular, methods for making a defined subset of dendritic cells are provided.
6855519 Methods for enhancing the production of interferon in cell culture  
Methods for enhancing the production of interferons in animal cell culture are described. These methods rely on the manipulation of the cellular levels of certain inducers of interferon...
6607914 Camello gene family and uses thereof  
The present invention provides a purified and isolated nucleic acid encoding a camello protein. The present invention also provides a vector comprising nucleic acid encoding camello, a host cell...
6489144 Methods for enhancing the production of interferon in cell culture  
Methods for enhancing the production of interferon in animal cell culture are described. These methods rely on the manipulation of the cellular levels of certain inducers of interferon production,...
6312924 Murine interferon-α  
Interferons represent an important class of biopharmaceutical products, which have a proven track record in the treatment of a variety of medical conditions, including the treatment of certain...
6159712 Methods for enhancing the production of interferon in cell culture  
Methods for enhancing the production of interferons in animal cell culture are described. These methods rely on the manipulation of the cellular levels of certain inducers of interferon...
6156542 Method for production of native human leukocyte (alpha) interferon  
The invention relates to a process for the preparation of natural human alfa interferon from human blood by ammonium chloride haemolysis and purification by washing with buffered physiological...
5891443 Method to produce granulocyte colony stimulating factor from immortalized avian T lymphocytes to produce immortalized cells  
Immortal avian T lymphocyte cell lines which produce and secrete immune lymphokines are disclosed. These cell lines may be produced from T cells recovered from fowl which have been hyperimmunized...
5856179 Polypeptide production in animal cell culture  
A method of producing a polypeptide in fed batch cell culture is provided which involves an initial cell growth phase and a distinct production phase. In the initial growth stage, animal cells...
5834249 Process for production of protein  
A process for production of a desired protein comprising the steps of: a culturing animal cells capable of producing the desired protein in a medium containing trichostatin compounds; and...
5731193 Recombinant DNA and transformant containing the same  
Insertion of IFN-alpha promoters in recombinant DNAs improves their expression efficiencies for useful polypeptides. Expression of such a recombinant DNA in host cells of mammalian origin is...
5698194 Method for making a medicament for treating secondary immunodeficiency  
A method of producing a natural nonrecombinant cytokine mixture is disclosed including the steps of immobilizing at least one mitogen in a tissue culture vessel. An isolated population of...
5676942 Composition containing human alpha interferon species proteins and method for use thereof  
This invention provides alpha interferon compositions comprising one or a mixture of selected highly antiviral interferon proteins, which compositions are characterized by increased anti-viral...
5672692 Purification of human myelomonocyte interferon gamma with an immobilized antibody  
A human myelomonocyte interferon-gamma having a novel polypeptide and carbohydrate chain structure is produced by propagation of an established human myelomonocyte in vitro or after being...
5563120 Cytokine preparation for immunotherapy  
A cytokine composition is prepared for use in immunotherapy of various diseases. The composition is prepared by culturing leucocytes previously infected with a virus in a culture medium containing...
5554515 Preparation of a monoclonal antibody specific to human myelomonocyte interferon-gamma  
A human myelomonocyte interferon-gamma having a novel polypeptide and carbohydrate chain structure is produced by propagation of an established human myelomonocyte in vitro or after being...
5518899 Preparation of human myelomonocyte interferon-gamma  
The present invention relates to a novel human interferon-gamma derived from an established human myelomonocyte, a process to prepare said interferon-gamma, and its use. The human myelomonocyte...
5362490 Human myelomonocyte interferon-gamma, and process for preparation and use thereof  
The present invention relates to a novel human interferon-gamma derived from an established human myelomonocyte, a process to prepare said interferon-gamma, and its use. The human myelomonocyte...
5308626 Lymphokine activated effector cells for antibody-dependent cellular cytotoxicity (ADCC) treatment of cancer and other diseases  
This invention relates to processes and compositions for the immunotherapeutic treatment of cancer and non-malignant tumors. More particularly, this invention relates to processes and compositions...
5272082 Cytotoxic T-ALL cell lines and uses therefor  
The invention provides cytotoxic T-ALL cell lines, and modified cytotoxic T-ALL cell lines which contain a heterologous DNA sequence. The DNA sequence may encode a product capable of stabilizing...
4966843 Expression of interferon genes in Chinese hamster ovary cells  
DNA constructs are prepared which operably link human interferon genes, selective, eukaryotic marker genes, and promoter and expression control sequences for the expression of human interferon in...
4948730 Modulation of animal cellular responses with compositions containing 8-substituted guanine derivatives  
Compositions and methods for their use in modulating animal cellular responses are disclosed. The compositions include as an active agent an effective amount of an 8-substituted guanine derivative...
4929443 Method of treating interferon sensitive diseases, and a method and device for preparing γ-interferon containing preparation  
Methods and means for treating interferon-sensitive diseases are disclosed, wherein a whole blood sample is taken from a patient suffering from such disease and is incubated in vitro together with...
4908432 Novel polypeptide having gamma-interferon activity  
The present invention provides a peptide having an amino acid sequence of less than about 100 amino acids, immunochemically reactive with an antibody directed against human gamma-interferon, and...
4882147 Novel polynucleotide analogs, methods for inhibiting nucleic acid polymerases and methods for inducing synthesis of interferon  
Polyribonucleotide analogs which are partially substituted by the introduction of mercapto groups and fluorine at the 5-position of some of their cytosine and uracil bases possess effective in...
4803163 Preparation of a protein fraction exhibiting cell growth-inhibiting activity  
A protein fraction isolated from tissue cultures of human diploid fibroblasts or lymphoblastoid cells inhibits the growth of heterologous human cells.
4764461 Tellurium and selenium compounds for the induction of in vivo and in vitro production of cytokines  
Certain tellurium compounds have been found to have the ability to stimulate the in vivo and in vitro production of cytokines and their receptors. These compounds may be utilized in the treatment...
4758510 Simplified in-vitro interferon production  
Interferon is produced in-vitro from whole blood, obtainable from animals or humans including blood from corpses or retroplacental blood, in a simplified non-critical process preferably carried...
4723000 Human interferon gamma and interleukin-2  
A process for producing unique human interferon gamma and interleukin-2 by chromatographic fractionation utilizing ion exchange and metal chelate chromatography. The interferon gamma and...
4696899 Process for the preparation of human leukocyte and human gamma interferon  
The invention relates to a process for the preparation of α- and γ-interferon by isolating the buffy coat fraction of blood, removing the erythrocytes, suspending the leukocytes in a suitable...
4683199 Interleukin-2 dependent cytotoxic T-cell clones  
Interleukin-2 dependent cytotoxic cultured T-cell lines are found to produce α, β, and γ interferon, as well as interleukin-2, when stimulated by mitogenic or antigenic agents.
4680261 Process for producing interferon  
A process for producing interferon comprises culturing interferon-producing mammalian cells in a cell culture medium containing at least one compound selected from the group consisting of ascorbic...
4617378 Purification of biologically active human immune interferon  
There is provided a process for purification of human immune interferon (IFN-γ) to homogeneity without appreciable loss of biological activity by the use of chromatography on controlled-pore...
4614651 Interferon epsilon  
Disclosed is a new material having antiviral activity designated interferon epsilon. The material may be produced, for example, by exposing primary, diploid human epithelial cells to a virus and...
4606917 Synergistic antiviral composition  
Combinations of 9-(1,3-dihydroxy-2-propoxymethyl) guanine or a pharmaceutically acceptable salt thereof, with β-interferon show a surprisingly high degree of synergism in their activity against...
4591557 Process and materials for producing soluble biological mediators from white blood cells  
A process and cellular system for producing soluble biological mediators, including cytokines, lymphokines, monokines and interferons, and mRNA therefor, from white blood cells is provided. The...
4548900 Method of interferon production  
A method for the mass production of interferon, wherein cultured cells are brought into contact with at least one polyhydric alcohol, thereby achieving a remarkable increase in the production of...
4541952 Purification method of human interferon  
A method for the purification of human interferon by the successive treatments of a crude interferon solution with an immobilized carrier which is coupled with a blue dye and a chelating carrier...
4526782 Process for recovering interferon  
Interferon can be recovered simply by contacting an aqueous solution containing interferon which is induced and produced from cells of human origin capable of producing interferon, with a...
4503035 Protein purification process and product  
An improved process for purifying proteins, particularly proteins having molecular weights in excess of 12,000 involves novel applications of high performance liquid chromatography on a...
4499014 Method for purifying gamma-interferon  
A method is provided for restoring some or all of the activity of gamma-interferon which has been in contact with an acidic solution comprising the steps of: (a) placing the gamma-interferon in a...
4496537 Biologically stable alpha-interferon formulations  
The addition of glycine or alanine prior to lyophilization significantly improves the biological stability of alpha type interferon formulations.
4490357 Simplified in-vitro interferon production  
Interferon is produced in-vitro from whole blood, obtainable from animals or humans including blood from corpses or retroplacental blood, in a simplified non-critical process preferably carried...
4486407 Method for enhancing production of interferon  
Interferon production, in vivo and in vitro, is enhanced by adding to the interferon production system, a chelating compound such as N-acetic acid derivatives of ammonia or polyamines. In one...
4485038 Method for the production and purification of human leukocyte interferon  
A process for the production and purification of human interferon derived from leukocyte of lymphoblastoid cell origin characterized by a sequence of steps involving chromatography of a solution...
4482708 3', 5'-Dinucleoside phosphates of 5,6-dichloro-1-β-D-ribofuranosyl-1-benzimidazole and methods of making and using the same  
A new 3',5'-dinucleoside phosphate, the pharmaceutically acceptable salts thereof and intermediates therefor. The 3',5'-dinucleoside phosphate of 5,6-dichloro-1-β-D-ribofuranosyl-1-benzimidazole...
4480032 Natural mixture of Type I and Type II interferons  
Pharmaceutical compositions comprising a natural mixture of Type I and Type II interferons which are produced by induction with measles vaccine virus in leukocyte cells obtained from human donors...
4469790 Continuous and spontaneous interferon producing lymphoblastoid cell lines, process for preparing the same, and process for the human interferon production by the same  
Process for preparing a continuous and spontaneous human-interferon-producing lymphoblastoid cell line which involves (a) transforming human lymphocytes isolated from a human infant from birth up...
4460685 Method of enhancing the production of human γ Interferon  
A method for stimulating the production of human IFN-γ in a culture of cells is disclosed. In this method, an effective amount of a diterpene compound is added to a culture of IFN-γ producing cells.

Matches 1 - 50 out of 79 1 2 >