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9040249 Pan-kinase activation and evaluation of signaling pathways  
Methods and reagents are provided for determining the activation state of a signal transduction pathway signaling protein. There exists a need in the art for methods that can monitor the efficacy...
9034589 Magnetic separation of cells  
An apparatus, system, and method for magnetic separation of cells are disclosed. By combining inkjet printing technology and magnetic labeling of cells, accurate cell counts are obtained using an...
9029096 Assay and method  
The present invention relates to a method and assay useful for determining the sensitivity of the cells of a subject to genetic damage from electromagnetic radiation. The assay may comprise a...
9023647 Monocyte activation test better able to detect non-endotoxin pyrogenic contaminants in medical products  
An improved monocyte activation test is described that is better able to detect non-endotoxin pyrogens in medical products, in which a sample is incubated with a monocyte-containing reagent in an...
9018245 Method for promoting immune response comprising inhibiting CD22 function in B cells  
The purpose of the present invention is to elucidate a relationship between deregulation of signaling by CD22 and a rapid response of B cells by IgG-BCR and the like, and to provide a method...
9005908 Mycobacterial infections  
The present invention relates to Mycobacterial infections and provides a method of diagnosing infections of Mycobacterium avium subsp. paratuberculosis (Map), the causative agent of Johne's...
9005909 Whole blood assay for measuring AMPK activation  
A method of sample analysis is provided. In certain embodiments, the method comprises: a) labeling cells of a blood sample using an antibody that specifically binds to phospho-AMPK or a...
8993244 Screening for compounds having immunosuppressant activity by testing impact on leukocyte-specific calcium fluxes  
The invention relates to an assay for the identification of a compound having immunosuppressant activity, wherein a candidate compound is analyzed whether it blocks the Ca2+ flux in coronin 1...
8986702 Antibodies and processes for preparing the same  
Provided herein are various processes for the improved production of antibody producing organisms, antibody producing tissues, antibody producing cells and antibodies. In certain embodiments,...
8981100 Use of novel coumarins as glutathione and thiol labels  
Fluorescent quinolizinocoumarin compounds substituted with electrophilic reactive groups that bind thiol compounds are described. The compounds are useful in detecting oxidative stress and...
8969021 Methods and compositions for detecting non-hematopoietic cells from a blood sample  
The present invention recognizes that diagnosis and prognosis of many conditions can depend on the enrichment of rare cells, especially tumor cells, from a complex fluid sample such as a blood...
8969100 Method for detecting afferent lymph vessel inflow regions and method for identifying specific cells  
Regions where metastatic cancer cells can exist are detected with high accuracy in a sentinel lymph node. Quantum dots are injected into the vicinity of a cancer in a living body, thereby...
8962263 Methods and compositions for detecting the activation state of multiple proteins in single cells  
The invention provides methods and compositions for simultaneously detecting the activation state of a plurality of proteins in single cells using flow cytometry. The invention further provides...
8961968 Human monoclonal antibodies against CD25  
Isolated human monoclonal antibodies which bind to and inhibit human CD25, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced by a...
8951747 Method for modulating activity of T lymphocytes  
The invention relates to methods and compositions which modulate T lymphocyte activity. It has been found that two, T lymphocyte receptors, especially TCR and CD8, are present at a distance from...
8951793 Method of making an isolated population of FOXP3+ regulatory T cells  
Disclosed are methods of isolating and using a population of FOXP3+ regulatory T cells in a variety of preventative and therapeutic approaches to autoimmune diseases, graft-versus-host disease and...
8945857 Methods of isolating cells and generating monoclonal antibodies  
The invention provides methods for isolating cells, particularly antibody-secreting cells that have a high likelihood of secreting antibodies specific for a desired antigen for the purpose of...
8940494 Microfluidic assay in idealized microvascular network for characterization of leukocyte adhesion cascade  
Methods of assaying the leukocyte adhesion cascade (LAC) and monitoring leukocyte rolling, adhesion, and/or migration can be implemented with an apparatus that includes an idealized microvascular...
8933014 HJURP peptides and vaccines including the same  
Isolated peptides derived from SEQ ID NO: 50 and fragments thereof that bind to an HLA antigen and induce cytotoxic T lymphocytes (CTL) and thus are suitable for use in the context of cancer...
8927290 Compositions and methods for the detection of antibodies to native human leukocyte antigen  
Provided herein are compositions comprising native and denatured human leukocyte antigens (HLA) and methods of making said compositions. Also provided herein are methods and kits for the detection...
8921321 Therapeutic strategies for prevention and treatment of alzheimer's disease  
The invention relates to therapeutic agents for use in the prevention or treatment of Alzheimer's disease. In particular the invention relates to use of inhibitors of cell cycle reentry and...
8912385 Rapid production of monoclonal antibodies  
The present invention relates to genetically altered hybridomas, myelomas and B cells. The invention also relates to utilizing genetically altered hybridomas, myelomas and B cells in methods of...
8911952 Method for integrin ligand discovery  
This invention relates generally to integrin ligand discovery and to a method of integrin ligand discovery base upon induction of ligand-induced epitopes. Such ligands have the potential to be...
8889367 Methods and kits for diagnosing osteoarthritis and predicting progression  
This disclosure relates to methods and kits for diagnosing osteoarthritis and for determining the progression of osteoarthritis in a subject.
8883491 Systems and methods for counting cells and biomolecules  
The present invention generally relates to systems and methods for counting biomolecules or cells. In certain embodiments, the invention provides a cell counting or biomolecule counting system...
8865420 Methods and compositions for risk stratification  
The present invention provides an approach for the simultaneous determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of...
8865479 Screening assays and methods  
Screening assays and methods of performing such assays are provided. In certain examples, the assays and methods may be designed to determine whether or not two or more species can associate with...
8846322 Method and kit for isolating target cell  
Provided are a method and kit for isolating a target cell by using particles comprising polymers having positive charge and negative charge and at least one antibody bound to polymers. The target...
8840899 Use of mTOR inhibitors to enhance T cell immune responses  
It is disclosed herein that treatment of a subject with an mTOR inhibitor enhances antigen-specific T cell immune responses. Thus, provided herein is a method of enhancing an antigen-specific T...
8835188 Screening assays and methods  
Screening assays and methods of performing such assays are provided. In certain examples, the assays and methods may be designed to determine whether or not two or more species can associate with...
8835187 Screening assays and methods  
Screening assays and methods of performing such assays are provided. In certain examples, the assays and methods may be designed to determine whether or not two or more species can associate with...
8828671 Simultaneous assay of target and target-drug binding  
Whole cell, simultaneous target and drug-target assay using differentially labeled antibodies and flow cytometry. First antibody binds to total target and second antibody binds to the drug binding...
8828737 Use of focused light scattering techniques in biological applicationa  
Methods for using focused light scattering techniques for the optical sensing of biological particles suspended in a liquid medium are disclosed. The optical sensing enables one to characterize...
8815526 Methods and reagents for identifying/isolating T regulatory (Treg) cells and for treating individuals  
An affinity ligand is reactive to the GARP protein may be capable of binding to an extracellular domain of GARP protein expressed on regulatory T (Treg) cells. The affinity ligand may be an...
8815527 Methods and compositions for detecting the activation state of multiple proteins in single cells  
The invention provides methods and compositions for simultaneously detecting the activation state of a plurality of proteins in single cells using flow cytometry. The invention further provides...
8802384 Method or system using biomarkers for the monitoring of a treatment  
The present invention relates to biomarkers to monitor the activity of the compound 3-Z-[1-(4-(N-((4-methyl-piperazin-1-yl)-methylcarbonyl)-N-me thyl-amino)-anilino)-1-phenyl-methylene]-6-methoxyca...
8785140 Cd4+ Cd25+ T-cells activated to a specific antigen  
The invention relates to a method of assessing whether a subject comprises CD4+,CD25+ T cells that have been activated to a specific antigen. The method comprises the steps of obtaining from the...
8778620 Methods for diagnosis, prognosis and methods of treatment  
The present invention provides an approach for the determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in...
8772049 Screening assays and methods  
Screening assays and methods of performing such assays are provided. In certain examples, the assays and methods may be designed to determine whether or not two or more species can associate with...
8771971 Methods and kits for measurement of lymphocyte function  
The present invention provides simple and rapid methods for measuring the function of a desired subset of lymphocytes, for example, T cells, B cells or NK cells. In addition, the present invention...
8765392 Methods for diagnosis of myelodysplastic syndromes (MDS)  
The present invention relates to methods and kits for diagnosing, ascertaining the clinical course of myelodysplastic syndrome (MDS) and ascertaining response to a therapy regimen of...
8765391 Cell assay kit and method  
A method and kit for assaying a cell sample for the presence of at least a threshold number of cells of a given type are disclosed. The kit includes an assay device having a sample chamber for...
8765692 Modified-galactosyl ceramides for staining and stimulating natural killer T cells  
Modified glycolipid compounds are provided. Also disclosed are methods for activating an NKT cell, methods of stimulating an immune response in a subject, and methods suitable for labeling NKT cells.
8759012 Method of determining dose and administration of statin  
The object of the present invention is to provide a method of determining the dose and/or administration of statins to a patient suffering from a cardiovascular disease. The object is achieved by...
8748113 Methods for detecting and monitoring circulating cancer stem cells  
Provided herein are compositions, methods, and kits useful for detecting whether a subject has or is likely to develop a cancer and for monitoring, staging and examining a cancer patient. Also...
8741576 Heteroclitic analogs and related methods  
Heteroclitic analogs of Class I epitopes are prepared by providing conservative or semi-conservative amino acid substitutions at positions 3 and/or 5 and/or 7 of these epitopes. The analogs are...
8715619 Compositions and methods for treating haematological proliferative disorders of myeloid origin  
The disclosure relates to methods and compositions effective in the diagnosis, prognosis and treatment of human hematopoietic cancers. In particular, the disclosure provides tumor-associated genes...
8709801 Kit and method for the capture of tumor cells  
The invention relates to a kit and method for the capture of tumor cells in a body fluid sample or a serum-containing sample. The kit and method of the invention can capture living tumor cells but...
8709736 Biomarker for Barrett's Oesophagus  
The present invention relates to the use of TFF3 in the diagnosis and detection of Barrett's esophagus using non-invasive, non-endoscopic methods.
8697348 Mutations in the Bcr-Abl tyrosine kinase associated with resistance to STI-571  
The invention described herein relates to novel genes and their encoded proteins, termed Mutants Associated with Resistance to STI-571 (e.g., T315I Bcr-Abl), and to diagnostic and therapeutic...