Match Document Document Title
9034574 Agents for reversing epigenetic silencing of genes  
The present invention provides methods for discovering agents that are effective in reversing epigenetic silencing by inhibiting the interaction of methyl-binding (MBD) proteins with methylated...
9029082 Detection device for detecting biological microparticles such as bacteria, viruses, spores, pollen or biological toxins, and detection method  
A device for the detection of micro particles that can be marked by probes or antibodies capable of being detected by radiation has a filter, a supply system, and a detection system. Fluid to be...
9023595 Treatment of metastatic tumors  
The present invention is directed to methods and methods for the treatment, inhibition and/or reduction, and detection of metastatic tumors. In some embodiments, the inventive methods include...
9017944 Methods for the prognosis of breast cancer  
The present invention relates to modified and genomic sequences, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genomic DNA, as well as to a method for...
9012622 Compositions and methods using siRNA molecules and siRNA cocktails for the treatment of breast cancer  
The present invention provides small interfering RNA (siRNA) molecules, compositions containing the molecules, and methods of using the molecules and compositions to treat breast cancer. In one...
9012145 Protein tyrosine phosphatase mutations in cancers  
Tyrosine phosphorylation, regulated by protein tyrosine phosphatases (PTPs) and kinases (PTKs), is important in signaling pathways underlying tumorigenesis. A mutational analysis of the tyrosine...
9006199 Methods and compositions for treating prostate cancer  
Treatment of prostate cancer by regional and prolonged release of one or more nucleotide-based RNAi agents is provided.
8999647 Methods of subclassification of ductal carcinoma in situ of the breast  
Provided herein are methods of determining the aggressiveness or indolence of a ductal carcinoma in situ lesion. Also provided are methods of developing treatment plans for subjects with a ductal...
8999643 Methods and assays for the detection of alternative lengthening of telomeres (ALT) activity in cells  
The invention relates to methods and assays for the detection of active Alternative Lengthening of Telomeres (ALT) activity in cells. The methods and assays involve detecting or assaying for...
8999634 Nucleic acid detection combining amplification with fragmentation  
Provided herein are methods and compositions for detection of a nucleic acid target in a sample. The methods and compositions use primer directed amplification in conjunction with nucleic acid...
8999633 Compositions, kits, and methods for identification, assessment, prevention and treatment of pancreatic adenocarcinoma in humans  
The invention relates to compositions, kits, and methods for detecting, characterizing, preventing, and treating human pancreatic adenocarcinoma. A variety of chromosomal regions (MCRs) and...
8999648 System and method for classification of patients  
A system (100) for classifying a biological test sample, including a database (112) populated with reference expression data. The reference expression data includes expression levels of a...
8987266 EGFR mutations  
The present invention relates to mutations in Epidermal Growth Factor Receptor (EGFR) and methods of detecting such mutations as well as prognostic methods method for identifying a tumors that are...
8980638 Use of IMP3 as a prognostic marker for cancer  
Provided herein are methods and compositions for the prognostic evaluation of a patient suspected of having, or having, cancer by assessing the expression of IMP3 in a biological sample of a...
8980549 MicroRNA patterns for the diagnosis, prognosis and treatment of melanoma  
The present invention relates to methods for diagnosing, staging, prognosticating and treating melanoma based on evaluating the expression of specific patterns of oncogenic or suppressive microRNA...
8975036 Methods for improved diagnosis of dysplasias  
The present invention relates to a method for improved diagnosis of dysplasias based on simultaneous detection of INK4a gene products and at least one marker for cell proliferation. Particularly...
8969046 Methods for detecting epigenetic modifications  
A method of detecting a predisposition to, or the incidence of, cancer in a sample comprises detecting an epigenetic change in at least one gene selected from an NDRG4/NDRG2 subfamily gene, GATA4,...
8969000 Prognostic gene expression signature for non small cell lung cancer patients  
The invention relates to a method of typing non-small cell lung cancer by determining RNA levels for a set of genes. The typing can be used for determining a metastasizing potential of the cancer...
8962236 Epigenetic biomarker ADAMTS9 for diagnosis and prognosis of gastric cancer  
The present invention provides a method for diagnosing and determining prognosis of gastric cancer in a subject by detecting suppressed expression of the ADAMTS9 gene, which in some cases is due...
8956820 Method for detecting cancer cells using vertically aligned carbon nanotubes  
The various embodiments herein provide a method for detecting the cancerous cells using the carbon nanotubes. The method comprises preparing a solution of the tissue cells. The prepared solution...
8951735 Genetic variants for breast cancer risk assessment  
The invention pertains to certain genetic variants that have been determined to be susceptibility variants of breast cancer. Methods of disease management, including diagnosing increased...
8945572 Methods and compositions for the diagnosis and treatment of cancer  
Methods and compositions are provided for the diagnosis and treatment of colorectal cancers associated with amplification or overexpression of the FGFR2 gene.
8945486 Microwell device  
A microwell device is provided. The device includes a plate having a upper surface. The upper surface has first and second recesses formed therein. Each recess has an outer periphery. First and...
8945849 Method for diagnosing esophageal cancer  
This invention relates to a composition, kit, or DNA chip for use in diagnosis of esophageal cancer, which comprises a plurality of polynucleotides selected from the group consisting of...
8947516 High-resolution 3D imaging of single semiconductor nanocrystals  
A method of imaging microscopic objects includes determining the relative depths of two or more semiconductor nanocrystals by analyzing images of the semiconductor nanocrystals at varying...
8945829 Distinguishing benign and malignant indeterminate thyroid lesions  
The application describes methods for accurately evaluating whether thyroid test samples, especially indeterminate thyroid samples, are benign or malignant.
8940497 Enzyme regulating ether lipid signaling pathways  
A multidimensional profiling strategy that combines activity-based proteomics and metabolomics was used to determine that an active protein, which is a previously uncharacterized enzyme highly...
8940480 MicroRNA based method for anti-colorectal cancer effects and prognosis of colorectal cancer  
The present invention discloses a method of providing anti-oncogenic effects in a subject suffered from colorectal cancer. The present invention also discloses a method for screening an...
8936914 Methods of renal cell carcinoma prognosis and treatment selection with carbonic anhydrase IX  
The present invention provides methods of aiding in a renal cell carcinoma prognosis that include quantifying expressed carbonic anhydrase in samples derived from renal cell carcinoma patients....
8936906 Potentiator of activity of anti-cancer agent and use thereof, and biomarker for prediction of prognosis in cancer patient and use thereof  
Disclosed is a means for improving the clinical outcomes of cancer therapy. Specifically disclosed is an activity potentiator comprising a compound capable of inhibiting the expression of RFP (RET...
8932993 Method of testing for endometriosis and treatment therefor  
The present invention relates to novel genetic markers associated with endometriosis and risk of developing endometriosis, and methods and materials for determining whether a human subject has...
8927512 RNA aptamer specifically binding to carcinoembryonic antigen and use thereof  
Provided are RNA aptamer specifically binding to cancer metastasis-inducing domain of CEA (Carcinoembryonic antigen), a composition for prevention and/or inhibition and/or diagnosis of cancer...
8921050 Methods of diagnosing renal cell carcinoma  
Compositions and methods are provided for preventing or treating neoplastic disease in a mammalian subject. A composition is provided which comprises an enriched immune cell population reactive to...
8923598 Methods and apparatus for diagnosis and/or prognosis of cancer  
The subject invention concerns methods for the detection, diagnosis, and/or prognosis of cancer by analyzing centrosomal features. In one embodiment, a method includes receiving an image of one or...
8921051 Methods and means for typing a sample comprising colorectal cancer cells  
The invention relates to a method of typing colorectal cancer cells by determining the RNA levels of a set of signature genes. Said typing can be use for predicting a risk for recurrence of said...
8924232 Device and method for comparing molecular signatures  
A method (10) for clinical decision support by comparison of multiple molecular signatures of biological data is provided. The method comprises comparing at least two of said molecular signatures...
8916696 Aptamer-mRNA conjugates for targeted protein or peptide expression and methods for their use  
An aptamer-mRNA conjugate is provided. The aptamer-mRNA conjugate may include an aptamer component that binds a membrane associated protein on a target cell and an mRNA component that is expressed...
8916530 Individualized cancer therapy  
In certain embodiments, the invention provides methods for treating cancer, comprising: (a) obtaining a specimen of cancer tissue and normal tissue from a patient; (b) extracting total protein and...
8911936 MicroRNA fingerprints during human megakaryocytopoiesis  
Described herein are methods of diagnosing a cancer and/or myeloproliferative disorder using microRNAs. Also described are compositions and methods related to cancers and myeloproliferative disorders.
8895245 Inhibitors of human EZH2 and methods of use thereof  
The invention relates to inhibition of wild-type and certain mutant forms of human histone methyltransferase EZH2, the catalytic subunit of the PRC2 complex which catalyzes the mono- through...
8894975 Methods of leukemia cell detection  
Methods are provided for, inter alia, determining the presence of leukemia cells in a subject, determining the change or potential change in the number of leukemia cells in the subject with time,...
8889361 Gene expression signatures in enriched tumor cell samples  
The invention is embodied in methods for finding gene expression signatures of circulating melanoma cells, ovarian, breast, colorectal cancer cells, and circulating endothelial progenitor cells,...
8889647 Recombinant protein for siRNA delivery and composition comprising the same  
Recombinant proteins for siRNA delivery and a composition including same. These recombinant proteins include a p19 RNA binding protein and a target oriented peptide and can secure the stability of...
8889649 Composition containing antisense oligonucleotide to micro RNA  
Provided is a composition that contains an antisense oligonucleotide to a micro RNA and is capable of inhibiting the growth of cancer cells. The present invention, as one aspect, relates to a...
8889644 GNAQ targeted dsRNA compositions and methods for inhibiting expression  
The invention relates to a double-stranded ribonucleic acid (dsRNA) targeting a G-alpha q subunit (GNAQ) of a heterotrimeric G gene, and methods of using the dsRNA to inhibit expression of GNAQ.
8884000 Saporin-L1 inhibitors and uses thereof  
Inhibitors of saporin-L1 are disclosed, as are related compositions and uses thereof, in particular in cancer therapy that employs saporin-L1-linked immunotoxins.
8883749 Transcription factor inhibitors and related compositions, formulations and methods  
The present invention provides small molecules useful to affect cancer cells, along with related methods. The present compounds, formulations, kits and methods are useful for a variety of...
8877445 Methods for identification of tumor phenotype and treatment  
The disclosure relates to methods for identifying a tumor as an E2F-responsive gene over-expressing (ERGO) tumor, methods of determining the likelihood that an ERGO tumor patient will survive to a...
8868352 Predicting response to chemotherapy using gene expression markers  
The present invention provides gene expression information useful for predicting whether a cancer patient is likely to have a beneficial response to treatment with chemotherapy, comprising...
8865408 Signature for the diagnosis of cancer aggressiveness and genetic instability  
The present invention relates to a method for diagnosing aggressiveness and/or genetic instability of a cancer in a patient from a cancer sample of the patient. The method includes measuring in...