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8834896 Vault compositions for immunization  
Methods and compositions are provided herein for immunizing a subject by administering to the subject an effective amount of an immunogenic peptide or an immunogenic fragment or variant thereof...
8742202 Transformation of sugar cane  
Methods for the transformation of sugar cane are provided. The methods comprise utilizing sugar cane immature shoots as the source of plant material for transformation. Segments of the immature...
8524368 Charge-dynamic polymers and delivery of anionic compounds  
The present invention provides dynamic charge state cationic polymers that are useful for delivery of anionic molecules. The dynamic charge state cationic polymers are designed to have cationic...
8513019 Apparatus and method for genetically transforming cells  
A fluid containing cells and free genetic material is acoustically coupled to a propulsion surface of a diaphragm. A blast-receiving surface of the diaphragm is acoustically coupled to an...
8435791 Controlled laser treatment for non-invasive tissue alteration, treatment and diagnostics with minimal collateral damage  
A highly controlled and precise system, device and method for tissue and cellular alteration and treatment below or at surfaces with a laser. The present invention is characterized by ultra low...
8415160 Transfection with micro explosion enacted by coated dry ice particles  
Disclosed is a transfection method, which includes the steps of: (a) adhering the gene fragments to dry ice particles; (b) adding the dry ice particles into the medium/liquid that contains target...
8349364 Nucleic acid coated particles suitable for temporary storage  
Particles are provided which are suitable for delivery from a particle-mediated delivery device. The particles are obtained by precipitating a nucleic acid on inert metal carrier particles in the...
8343766 Method and apparatus for sustaining viability of biological cells on a substrate  
A method for the transient transformation of a living biological cell having an intact cell membrane defining an intracellular domain, and an apparatus for the transient transformation of...
8323976 Alterations utilizing nanoparticles  
Alterations utilizing nanoparticles. Certain embodiments of the invention are methods of delivering a substance to a target using a delivery-aid which includes nanoparticles. Those nanoparticles...
8263406 Enriched or purified population of motor neurons and its preparation from a population of embryonic stem cells  
The present invention is directed to a method of isolating an enriched or purified population of motor neurons from a population of embryonic stem cells. This method involves providing a...
8153432 Multiplex automated genome engineering  
The present invention relates to automated methods of introducing multiple nucleic acid sequences into one or more target cells.
8133580 Coating composition for a urinary catheter  
The invention relates to an article comprising a coating, which coating comprises at least two layers, of which the inner layer is a primer layer, comprising a supporting polymer network which is...
8097277 Charge-dynamic polymers and delivery of anionic compounds  
The present invention provides dynamic charge state cationic polymers that are useful for delivery of anionic molecules. The dynamic charge state cationic polymers are designed to have cationic...
7981446 Pharmaceutical compositions and methods for delivering nucleic acids into cells  
The present invention relates to methods of delivering nucleic acids into cells using a nucleic acid binding molecule containing a multimeric or spacer-incorporated protein transduction domain...
7955827 Controlled electroporation and mass transfer across cell membranes  
Electroporation is performed in a controlled manner in either individual or multiple biological cells or biological tissue by monitoring the electrical impedance, defined herein as the ratio of...
7927874 Method of transferring substance into cell  
There is provided a method by which multiple types of substances desired to be transferred into cells can be continuously transferred into multiple types of cells by a convenient procedure, a cell...
7892836 Pneumatic capillary gun for ballistic delivery of microscopic particles into tissue  
The capillary gun for delivery of ballistic particles to a target includes an inner capillary tube disposed concentrically within an outer capillary tube with the input end of the inner tube...
7888102 Cell line for producing coronaviruses  
The invention relates to the production of coronaviruses. In particular, the invention relates to methods for producing SARS-CoV by using cells expressing a functional SARS-CoV receptor.
7883720 Charge-dynamic polymers and delivery of anionic compounds  
The present invention provides dynamic charge state cationic polymers that are useful for delivery of anionic molecules. The dynamic charge state cationic polymers are designed to have cationic...
7718409 Controlled electroporation and mass transfer across cell membranes  
Electroporation is performed in a controlled manner in either individual or multiple biological cells or biological tissue by monitoring the electrical impedance, defined herein as the ratio of...
7699801 Advanced genetic vaccines  
Reagents useful in nucleic acid immunization techniques are described. More particularly, adjuvanted genetic vaccine compositions are described, as are methods of using those compositions for...
7544670 HoxD3, HoxA3 and HoxB3 compositions and methods for improved wound healing  
The present invention provides methods and compositions useful in localized transfer of genetic material or proteins. Moreover, the present invention provides methods and compositions for...
7482319 Vault and vault-like carrier molecules  
A method of using vaults as carrier molecules to deliver one or more than one substance to an organism, or to a specific tissue or to specific cells, or to an environmental medium. A vault-like...
7449449 Particle-mediated transformation of vertebrate tissue cells  
A method of transferring a gene to vertebrate cells is disclosed. The method comprises the steps of: (a) providing microprojectiles, the microprojectiles carrying polynucleic acid sequences, the...
7422861 Oligonucleotide transfection screening method  
Different-sequence peptoids, including lipid- and sterol-conjugated peptoids, are found to be effective in transfection of cells with oligonucleotides. Combinatorial libraries of such peptoids can...
7402435 Method of transferring a selected molecule into a cell  
A method of highly efficiently transferring various selected molecules into various cells and a method of fusing cells. Cells and/or selected molecules such as polynucleotide are treated with cold...
7402573 Use of nanoparticles for the DNA administration to a target organ  
The invention relates to the use of DNA-loaded nanoparticles for a transfection of DNA into cells in vitro or in vivo.
7358234 Induction of a protective immune response through microprojectiles coated with a DNA sequence encoding an immunogenic protein  
The present invention relates to a process for inducing a protective immune response in a mammal against a virus, in which a construct including a promoter and a DNA sequence encoding a protein or...
7344887 Methods and products for delivering biological molecules to cells using multicomponent nanostructures  
This invention is predicated on the present applicants' discovery that nanostructures comprising discrete regions of different composition can be used to deliver to a biological cell a desired...
7332339 Transferring materials into cells using porous silicon  
Porous and/or polycrystalline silicon are used in the delivery of substances into cells. The porous and/or polycrystalline silicon can be formed into micropiercers, microneedles and biolistic...
7279322 Electrospraying apparatus and method for coating particles  
An electrospraying apparatus and/or method is used to coat particles. For example, a flow including at least one liquid suspension may be provided through at least one opening at a spray dispenser...
7176186 Stimulation of cell-mediated immune responses by targeted particulate genetic immunization  
The present invention relates to various methods of genetic immunization for the purpose of providing antigen-specific immunity in a mammalian host, including a human host. The invention is based...
7132289 Method for introducing foreign matters into living cells  
A method for introducing a foreign matter into a cell, includes the steps of placing a small particle carrying a foreign matter at a part of a cell surface of a living cell, boring a hole in a...
7115582 HoxD3 and HoxA3 compositions and methods for improved wound healing  
The present invention provides methods and compositions useful in localized transfer of genetic material or proteins. Moreover, the present invention provides methods and compositions for...
7105052 Ordered array of magnetized nanorods and associated methods  
An ordered array of magnetized nanorods includes a plurality of metallic nanorods generally cylindrical in shape and including a nickel portion coated with a positively charged polyelectrolyte and...
7026166 Fluorogenic dyes  
The present invention relates to the use of fluorogenic or chromogenic dyes as reporter molecules for detecting cell entry by a specific molecule.
6929950 Microprojectile delivery system and particulate product  
The invention relates to a particulate product comprising at least one microprojectile; characterized in that the or at least one of the microprojectiles comprises silicon. The invention also...
6911586 Garden bean named ‘210104’  
A novel garden bean cultivar, designated ‘210104’, is disclosed. The invention relates to the seeds of garden bean cultivar ‘210104’, to the plants of garden bean line ‘210104’ and to methods for...
6875612 Monocyte-specific particulate delivery vehicle  
The inventive vector specifically directs entry into a cell of monocytic origin. The vector is composed of a nucleic acid component, a lysosome evading component and a particle that can be...
6870081 Potato cultivar FL1900  
A novel potato cultivar of the genus and species Solanum tuberosum, designated FL1900, is disclosed. The invention relates to the tubers of potato variety FL1900, to the plants of potato variety...
6869772 Method for labeling individual cells  
A method is provided for the labeling of individual cells. Labeling is accomplished by coating a particle with at least one dye or nucleic acid sequence encoding a marker protein. The particle is...
6770632 Folypolyglutamyl synthetase gene transfer to enhance antifolate  
Methods of killing neoplastic cells are provided. The invention relates to the use of folylpolyglutamyl synthetase (FPGS) gene transfer to enhance the sensitivity of several types of tumor cells...
6767743 Method and an apparatus for generating shockwave, a method and an apparatus for accelerating particles, an apparatus for delivering drugs, and a method and an apparatus for delivering DNA  
Method and apparatus for accelerating micro particles for use in delivering DNA or a solid drug in which a shockwave is generated by applying a short pulse energy to a surface of a metal foil to...
6730663 Targeting gene expression to living tissue using jet injection  
The present invention provides a method of targeting transient gene expression and stable gene expression from the exogenous administration of a DNA sequence, which sequence is less than a...
6653113 High efficiency gene targeting in mouse embryonic stem cells  
The present invention provides novel methods for modifying the genome of an animal cell which typically comprise the steps of: constructing a DNA molecule in which desired sequence modifications...
6642003 Human glucose-dependent insulin-secreting cell line  
Disclosed herein is a novel cell line of human pancreatic cells that secrete insulin in a glucose-dependent manner. The cell line comprises pancreatic cells, such as PANC-1 cells, which are...
6617153 Portable magneto-mechanical delivery device and method for delivery of reactive substances  
A method of delivery of reactive substances that are attached to magnetizable needle-like particles using a magneto-mechanical delivery device. The subject method and device can be utilized for...
6562376 DNA vaccines against poxviruses  
In this application is described a poxvirus naked DNA vaccine which protects animals against poxvirus challenge comprising IMV and EEV nucleic acids from poxvirus. Methods of use of the vaccine...
6479285 p53 as a regulator of cell differentiation  
The present invention involves the role of p53 in the differentiation of embryonic tissues. More particularly, the present invention provides methods of the blocking of p53 function in embryonic...
6436709 Low pressure-accelerated particle gene gun  
A gene gun is described wherein the contour design of the spray nozzle of the gene gun modifies the operation of the gene gun. A low pressure gas is used to accelerate the micro-particles that are...
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