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9034599 Polynucleotides encoding monomeric variants of the tetrameric eqFP611  
DNA encoding a monomeric variant of red fluorescent protein eqFP611 comprising an amino acid sequence selected from the group consisting of SEQ ID No. 1, SEQ ID No. 3 and SEQ ID No. 5. DNA...
9029080 Screening assay for insecticides  
The present invention relates to polypeptides, preferably from Drosophila melanogaster (DmShaI) as target for insecticides.
9023798 Cystinosin replacement factor  
The present invention provides compositions and methods for providing factor replacement therapy. In particular, the present invention provides replacement therapy for subjects suffering from...
9005939 Protoilludene synthase  
The present invention relates to an isolated, recombinant or synthetic polynucleotide encoding a polypeptide with protoilludene synthase activity and comprising a sequence selected from the group...
8993743 Chimeric surface active proteins  
The present invention relates to a nucleic acid molecule encoding a chimeric protein having the biochemical activity of a surface active protein, wherein said chimeric protein comprises: (a) an...
8969005 Gene targets associated with amyotrophic lateral sclerosis and methods of use thereof  
Compositions and methods for diagnosis and treatment of ALS are provided.
8961977 Antigenic mimics of discontinuous epitopes of pathogen recognized by broadly neutralizing antibodies  
The present invention relates to an anti-idiotypic polypeptide scaffold that includes two or more peptide sequences that mimic a discontinuous epitope of a pathogen that is recognized by or...
8952144 Vectors with modified initiation codon for the translation of AAV-REP78 useful for production of AAV  
The present invention relates nucleic acid constructs for the production of recombinant parvoviral (e.g. adeno-associated viral) vectors in insect cells, to insect cells comprising such constructs...
8945926 Expanding the eukaryotic genetic code  
This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include...
8926965 Nucleic acid encoding superoxide dismutase variants and methods of use thereof  
The present disclosure provides variant superoxide dismutase polypeptides, compositions comprising the polypeptides, and nucleic acids comprising nucleotide sequences encoding the polypeptides....
8906393 Biofilm inhibiting composition  
Polysaccharide-containing extracts isolated from a host cell containing nucleotide sequences encoding genes pamA, pamB and pamC, wherein the extract is capable of inhibiting biofilm formation...
8889374 Recombinant codon optimised factor H  
The present invention relates to recombinant factor H and variants and conjugates thereof and methods of their production, as well as uses and methods of treatment involving the materials.
8889381 Diterpene synthases and method for producing diterpenoids  
Provided herein are diterpene synthases (diTPS) and methods for producing diterpenoids. Also provided herein are nucleic acid sequences encoding diTPS, diTPS amino acid sequences, diTPS proteins,...
8859240 Dengue and West Nile viruses proteins and genes coding the foregoing, and their use in vaccinal, therapeutic and diagnostic applications  
The present invention relates to the development of viral vectors expressing different immunogens from the West Nile Encephalitis Virus (WNV) or the Dengue virus which are able to induce...
8853154 Fibronectin based scaffold domain proteins that bind to myostatin  
The present invention relates to fibronectin-based scaffold domain proteins that bind to myostatin. The invention also relates to the use of these proteins in therapeutic applications to treat...
8846886 Lepidopteran insect N-acetylglucosaminidase genes and their use in glycoengineering  
A transgenic insect cell line for production of elevated levels of recombinant glycoproteins comprising mammalian-like N-glycans is provided. Also disclosed are nucleic acid sequences encoding...
8846373 Methods of using a bacterial GlcNAc-6-P 2′- epimerase to promote sialylation of glycoconjugates  
The present invention relates to new methods to promote sialylation of glycoconjugates, including recombinant glycoproteins, in glycoconjugate production systems. The invention relates to methods...
8835131 Sesquiterpene synthase gene and protein  
The invention relates to sesquiterpene synthases and methods for their production and use. Particularly, the invention provides nucleic acids comprising the nucleotide sequence of citrus valencene...
8822180 Method of synthesizing a suppressor tRNA, DNA construct and use thereof for producing a non-natural amino acid-incorporated protein  
There are provided a DNA construct comprising a suppressor tRNA gene of a non-eukaryote containing no internal promoter functioning in a eukaryotic cell, and a eukaryotic or bacteriophage promoter...
8822181 Production of proteins  
A method for forming a fusion protein that is expressed as a recombinant protein body-like assembly in host eukaryotic cells and organisms other than higher plants as host systems is disclosed....
8765682 Method for in vivo residue-specific DOPA incorporation into mussel adhesive proteins  
The present invention relates to recombinant mussel adhesive protein wherein a DOPA residue is in vivo incorporated instead of a tyrosine residue, and a method for producing the same. More...
8722401 In vitro production of a cell population using feeder cells  
A method for the in vitro production of a cell population P′ from a cell population P, the production requiring the presence of at least one factor which is expressed by feeder cells, wherein a)...
8722363 Cytochrome P450S and uses thereof  
The invention features isolated cytochrome P450 polypeptides and nucleic acid molecules, as well as expression vectors and transgenic plants containing these molecules. In addition, the invention...
8716232 Use of endostatin peptides for the treatment of fibrosis  
C-terminal endostatin polypeptides are disclosed herein. Polynucleotides encoding these polypeptide, host cells transformed with the polynucleotides, and methods of using these polypeptides and...
8709775 Hydrolases, nucleic acids encoding them and methods for making and using them  
Provided are hydrolases, including lipases, saturases, palmitases and/or stearatases, and polynucleotides encoding them, and methods of making and using these polynucleotides and polypeptides....
8697417 Baculoviral vectors comprising repeated coding sequences with differential codon biases  
The present invention relates to production of proteins in insect cells whereby repeated coding sequences are used in baculoviral vectors. In particular the invention relates to the production of...
8697439 Direct protein delivery with engineered microvesicles  
The present invention relates to direct protein delivery with engineered micro vesicles.
8697440 Compositions and methods for producing gamma-carboxylated proteins  
The present invention relates to methods and tools for producing large quantities of gamma-carboxylated protein comprising: (i) culturing a cell adapted to express a protein which requires...
8679837 Inducible system for highly efficient production of recombinant Adeno-associated virus (rAAV) vectors  
Production of clinical grade gene therapy vectors for human trials remains a major hurdle in advancing cures for a number of otherwise incurable diseases. Disclosed herein are systems based on a...
8669379 Microbial production of 3,4-dihydroxybutyrate (3,4-DHBA), 2,3-dihydroxybutyrate (2,3-DHBA) and 3-hydroxybutyrolactone (3-HBL)  
The invention relates to recombinant cells and their use in the production of 3,4-dihydroxybutyrate, 2,3-dihydroxybutyrate and 3-hydroxybutyrolactone.
8647870 Use of biological photoreceptors as directly light-activated ion channels  
A biological photoreceptor, which is a directly light-controlled ion channel, including (i) an apoprotein and (ii) a light-sensitive polyene covalently bound to the apoprotein, the polyene...
8546105 Engineering intracellular sialylation pathways  
Methods for manipulating carbohydrate processing pathways in cells of interest are provided. Methods are directed at manipulating multiple pathways involved with the sialylation reaction by using...
8497094 Prevention and treatment of complement-associated eye conditions  
The invention concerns the prevention and treatment of complement-associated eye conditions, such as choroidal neovascularization (CNV) and age-related macular degeneration (AMD), by...
8445231 Cytochrome P450s and uses thereof  
The invention features isolated cytochrome P450 polypeptides and nucleic acid molecules, as well as expression vectors and transgenic plants containing these molecules. In addition, the invention...
8431769 Non-aggregating fluorescent proteins and methods for using the same  
Nucleic acid compositions encoding non-aggregating chromo/fluoroproteins and mutants thereof, as well as the proteins encoded by the same, are provided. The proteins of interest are polypeptides...
8420350 Glycosylation-deficient hepatocyte growth factor  
The invention provides a modified glycosylation-deficient HGF and a production method thereof. The glycosylation-deficient HGF is produced by introducing amino acid mutation(s) so that no...
8415525 Circovirus sequences associated with piglet weight loss disease (PWD)  
The genome sequences and the nucleotide sequences coding for the PWD circovirus polypeptides, such as the circovirus structural and non-structural polypeptides, vectors including the sequences,...
8383402 Trichoplusia ni cell line and methods of use  
An isolated cell from the cell line identified as TnT4. This cell may be infected with a baculovirus expression vector which may carry a heterologous nucleotide that encodes a polypeptide, such as...
8361760 Microbial production of 3-hydroxyacids from glucose and glycolate  
The invention relates to recombinant cells and their use in the production of 3-hydroxyacids such as 3,4-dihydroxybutyrate and 3-hydroxybutyrolactone.
8362206 Chimeric proteins and uses thereof  
The present invention provides a chimeric protein capable of killing or modifying a cell expressing abnormally high levels of a ligand of a receptor of the TNF/NGF family, comprising the amino...
8362201 Insecticidal compounds and methods for selection thereof  
A series of potent and highly specific insecticidal toxins characterized by an amino acid sequences SEQ ID NO: 2-35.
8357533 Preparation of inactivated artificial antigen presenting cells and their use in cell therapies  
Methods of processing inactivated artificial antigen presenting cells (aAPCs) and artificial antigen presenting cells with specificity for selected antigenic peptides are described, including...
8329420 Screening method for a substance that binds to an intracellular region of TLR4  
The present invention provides a method of screening for a drug for the prophylaxis or treatment of at least one disease selected from the group consisting of cardiac disease, autoimmune disease,...
8324362 Nucleic acid encoding 10FN3 polypeptide inhibitors of Type 2 vascular endothelial growth factor receptors  
The present disclosure relates to novel vascular endothelial growth factor receptor (VEGFR)-binding polypeptides and methods for using these polypeptides to inhibit biological activities mediated...
8263362 Cytochrome P450S and uses thereof  
The invention features isolated cytochrome P450 polypeptides and nucleic acid molecules, as well as expression vectors and transgenic plants containing these molecules. In addition, the invention...
8257957 Production of isoprenoids and isoprenoid precursors  
The present invention provides genetically modified host cells and use of same for producing isoprenoid compounds.
8247184 Assays using chimeric T1R polypeptides for identifying putative taste modulatory compounds  
This invention relates to chimeric taste receptors comprising the extracellular portion of one T1R or a variant or fragment thereof, either T1R1 or T1R2, and the transmembrane portion of another...
8211666 Sperm-specific cation channel, CATSPER1, and uses therefor  
Nucleic acid and protein sequences relating to a cation channel which is sperm-specific (CatSper1) are disclosed. The CatSper1 protein is shown to be specifically expressed in sperm and to be...
8202699 Use of biological photoreceptors as directly light-activated ion channels  
Use of a biological photoreceptor as light-controlled ion channel for the alteration of the ion conductivity of a membrane by means of light. The photoreceptor used comprises an apoprotein and a...
8202718 Ecdysone receptor-based inducible gene expression system  
This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to a...