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9034625 High fidelity restriction endonucleases  
Compositions and methods are provided for enzymes with altered properties that involve a systematic approach to mutagenesis and a screening assay that permits selection of the desired proteins....
9023634 High fidelity restriction endonucleases  
Compositions and methods are provided for enzymes with altered properties that involve a systematic approach to mutagenesis and a screening assay that permits selection of the desired proteins....
9006407 Therapeutic ribonucleases  
The present invention relates to the use of ribonucleases (RNases) in the treatment or prevention of disease.
8999641 Engineering and optimization of systems, methods and compositions for sequence manipulation with functional domains  
The invention provides for engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector...
8993233 Engineering and optimization of systems, methods and compositions for sequence manipulation with functional domains  
The invention provides for engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector...
8969061 Compositions, methods and related uses for cleaving modified DNA  
Compositions, methods and a kit are described relating to a novel family of enzymes which preferentially bind to a hydroxymethylated cytosine or a glucosylated hydroxymethylated cytosine and...
8945839 CRISPR-Cas systems and methods for altering expression of gene products  
The invention provides for systems, methods, and compositions for altering expression of target gene sequences and related gene products. Provided are vectors and vector systems, some of which...
8932814 CRISPR-Cas nickase systems, methods and compositions for sequence manipulation in eukaryotes  
The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one...
8911948 RNase H-based assays utilizing modified RNA monomers  
The present invention pertains to novel oligonucleotide compounds for use in various biological assays, such as nucleic acid amplification, ligation and sequencing reactions. The novel...
8889394 Multiple domain proteins  
Described herein are methods and compositions for generating and using fusion proteins.
8889356 CRISPR-Cas nickase systems, methods and compositions for sequence manipulation in eukaryotes  
The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one...
8871445 CRISPR-Cas component systems, methods and compositions for sequence manipulation  
The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one...
8865406 Engineering and optimization of improved systems, methods and enzyme compositions for sequence manipulation  
The invention provides for engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are compositions and...
8859266 Binary probe system for sensitive detection of target analytes  
The present disclosure encompasses systems, and their methods of use, for detecting a target analyte. The systems include a first and second oligonucleotide probe that associate together to form a...
8852911 Method of producing dicer  
The present disclosure provides a method for producing a Dicer polypeptide in a prokaryotic host cell. The present disclosure further provides a purified Dicer complex. The present disclosure...
8840882 Modified ribonucleases  
The present invention relates generally to conjugates of human ribonucleases and water-soluble polymers, compositions comprising the conjugates and methods of using the same. In particular, the...
8828698 Immobilized angiogenin mixtures and uses thereof  
Stabilized angiogenin compositions and methods of preparing a stabilized angiogenin compositions by covalent immobilization on a naturally occurring substrate, such as a polysaccharide substrate,...
8795965 CRISPR-Cas component systems, methods and compositions for sequence manipulation  
The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one...
8771945 CRISPR-Cas systems and methods for altering expression of gene products  
The invention provides for systems, methods, and compositions for altering expression of target gene sequences and related gene products. Provided are vectors and vector systems, some of which...
8771982 Chimeric molecule and nucleic acid encoding same  
The present invention relates, in general, to telomeres, and, in particular, to a method or effecting telomere elongation in mammalian cells. The invention further relates to a protein suitable...
8748698 Genome shuffling method for autogamous plants utilizing dominant male sterility obtained by gene engineering technique, and recurrent selection breeding system based on the genome shuffling method  
A genome shuffling method for autogamous plants, including producing individuals having the following three traits in a tight coupling linkage by a gene engineering technique selected from a...
8748146 Engineered nucleases and their uses for nucleic acid assembly  
Aspects of the invention provide engineered endonucleases that are characterized by both a long recognition sequence and specific cleavage outside of the recognition site. Engineered endonucleases...
8735127 Methods of and compositions for inhibiting the proliferation of mammalian cells  
A method of preventing, inhibiting and/or reversing cell motility, actin filament assembly or disassembly, proliferation, colonization, differentiation, accumulation and/or development of abnormal...
8715676 Production and uses of type I ribosome inactivating proteins  
Described herein are methods to express and purify recombinant type 1 ribosome inactivating proteins. Included are methods for using recombinant cucurmosin as a therapeutic to treat cancer and...
8715992 I-CreI meganuclease variants with modified specificity, method of preparation and uses thereof  
Method of preparing I-CreI meganuclease variants having a modified cleavage specificity, variants obtainable by said method and their applications either for cleaving new DNA target or for genetic...
8697065 Non-natural ribonuclease conjugates as cytotoxic agents  
The present invention is directed toward the delivery of a toxic protein to pathogenic cells, particularly cancer cells. In preferred embodiments, the toxic protein is a ribonuclease that has been...
8697062 Compositions and methods for ribonuclease-based therapeutics  
The present invention relates generally to conjugates of human ribonucleases and water-soluble polymers, compositions comprising the conjugates and methods of using the same. In particular, the...
8697395 Use of meganucleases for inducing homologous recombination ex vivo and in toto in vertebrate somatic tissues and application thereof  
Use of meganucleases for cleaving DNA in a non-human or an isolated human cell and, in some instances, inducing homologous recombination in said cells and to its application for genome engineering...
8697359 CRISPR-Cas systems and methods for altering expression of gene products  
The invention provides for systems, methods, and compositions for altering expression of target gene sequences and related gene products. Provided are vectors and vector systems, some of which...
8691549 High fidelity restriction endonucleases  
Compositions and methods are provided for enzymes with altered properties that involve a systematic approach to mutagenesis and a screening assay that permits selection of the desired proteins....
8685689 Restriction endonucleases, DNA encoding these endonucleases and methods for indentifying new endonucleases with the same or varied specificity  
Specified restriction endonucleases have been characterized for the first time by their amino acid and DNA sequences. These sequences and those with at least 90% identity thereto have been used as...
8673610 High fidelity restriction endonucleases  
Compositions and methods are provided for enzymes with altered properties that involve a systematic approach to mutagenesis and a screening assay that permits selection of the desired proteins....
8673591 Genetic incorporation of 3-aminotyrosine into reductases  
This invention provides reductase proteins that comprise NH2Y unnatural amino acid residues, systems of orthogonal elements for incorporating NH2Y into reductases and methods of using NH2Y amino...
8663964 Methods of treating human papillomavirus  
Two RNases (ranpirnase and the second embodiment disclosed in U.S. Pat. No. 5,728,805) are tested against human papillomavirus infections. QRT-PCR assays indicate that the RNases have anti-viral...
8652821 Stabilized protease-containing solutions for purifying RNA-free DNA  
The present invention provides compositions and methods for purifying RNA-free DNA from a sample.
8637291 High fidelity restriction endonucleases  
Methods and compositions are provided for engineering mutant enzymes with reduced star activity where the mutant enzymes have a fidelity index (FI) in a specified buffer that is greater than the...
8628945 High fidelity restriction endonucleases  
Compositions and methods are provided for enzymes with altered properties that involve a systematic approach to mutagenesis and a screening assay that permits selection of the desired proteins....
8629322 Genome shuffling method for autogamous plants utilizing dominant male sterility obtained by gene engineering technique, and recurrent selection breeding system based on the genome shuffling method  
A genome shuffling method for autogamous plants, including producing individuals having the following three traits in a tight coupling linkage by a gene engineering technique selected from a...
8628768 Therapeutic ribonucleases  
The present invention relates to the use of ribonucleases (RNases) in the treatment or prevention of disease.
8624000 Use of meganucleases for inducing homologous recombination ex vivo and in toto in vertebrate somatic tissues and application thereof  
A monomer of an I-CreI meganuclease variant wherein said monomer comprises mutations in the amino acid sequence of SEQ ID NO: 34, wherein said mutations include, (i) at least one and up to five...
8617867 Methods of and compositions for inhibiting the proliferation of mammalian cells  
A method of preventing, inhibiting and/or reversing cell motility, actin filament assembly or disassembly, proliferation, colonization, differentiation, accumulation and/or development of abnormal...
8604281 Transgenic plants with controlled distribution of a trait to progeny  
A process of producing transgenic multi-cellular plants or parts thereof expressing a trait of interest that has a controlled distribution of said trait to progeny, comprising (i) producing a...
8551753 Method of removing nucleic acid contamination in reverse transcription and amplification reactions  
The invention provides methods of removing nucleic acid contamination from reverse transcription reactions and hot-start PCR, wherein said hot-start PCR is a barrier hot-start PCR set up and/or...
8551426 Compound for inhibiting activity of ribonuclease, and container for storing nucleic acid containing the same  
Provided are an RNase activity inhibitory compound to effectively control the activity of the RNase promoting degradation of extracted RNAs and, in addition, a sample storage container including...
8535925 Modified DNase compositions and methods of use thereof  
Modified DNase polypeptides and methods of their use are provided.
8530214 Use of meganucleases for inducing homologous recombination ex vivo and in toto in vertebrate somatic tissues and application thereof  
The present invention relates to a polynucleotide encoding a monomer of an I-CreI variant said monomer comprising mutations in the amino acid sequence of SEQ ID NO: 34, wherein said mutations...
8476493 Reproductive ablation constructs  
The present invention relates to the regulation of reproductive development, particularly to the genetic ablation of reproductive tissues in angiosperm and gymnosperm species....
8470315 Non-natural ribonuclease conjugates as cytotoxic agents  
The present invention is directed toward the delivery of a toxic protein to pathogenic cells, particularly cancer cells. In preferred embodiments, the toxic protein is a ribonuclease that has been...
8440430 Modified dicer polypeptide and methods of use thereof  
A modified Dicer polypeptide is provided, which modified Dicer polypeptide exhibits enhanced catalytic activity. Also provided is a method for producing small regulatory RNAs from a dsRNA,...
8420782 Modular DNA-binding domains and methods of use  
The present invention refers to methods for selectively recognizing a base pair in a DNA sequence by a polypeptide, to modified polypeptides which specifically recognize one or more base pairs in...