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8945896 Ligand functionalized polymers  
Ligand functionalized substrates, methods of making ligand functionalized substrates, and methods of using functionalized substrates are disclosed.
8911986 Coatings containing polymer modified enzyme for stable self-cleaning of organic stains  
Temporary active coatings that are stabilized against inactivation by weathering are provided including a base associated with a chemically modified enzyme, and, optionally a first polyoxyethylene...
8871483 Biofuel cell electrocatalysts utilizing enzyme-carbon nanotube adducts  
The present disclosure provides multi-walled carbon nanotubes and carbon nanotubes (CNTs) displaying catalytic enzymes bound to the nanotube sidewalls and devices, such as electrodes,...
8835144 Dual-functional nonfouling surfaces comprising target binding partner covalently coupled to polymer attached to substrate  
Dual-functional nonfouling surfaces and materials, methods for making dual-functional nonfouling surfaces and materials, and devices that include dual-functional nonfouling surfaces and materials....
8802410 Mass-sensitive chemical sensor having a binding surface for ligands  
There is disclosed an analytical method and a sensor suitable for carrying out the method. More specifically, there is disclosed a method for preparing a mass sensitive chemical sensor capable of...
8796009 Clearcoat containing thermolysin-like protease from Bacillus stearothermophilus for cleaning of insect body stains  
A substrate or coating is provided that includes a protease with enzymatic activity toward a component of a biological stain. Also provided is a process for facilitating the removal of a...
8765393 Endotoxin-binding ligands and their use  
An affinity ligand-matrix conjugate of the structure Z-Spacer-[NX-A]m-NY-A-NK2 is useful for the isolation, separation, purification, characterization, identification or quantification of...
8697111 Osteochondral implant comprising osseous phase and chondral phase  
An osteochondral plug includes a first scaffold and a second scaffold. The first scaffold may be a solid scaffold containing one or more pendant reactive functional groups. The second scaffold...
8679807 Covalent immobilization of molecules comprising an amino group  
There is provided a method for covalent immobilization of at least one molecule comprising at least one amino group, said method comprising the sequential steps of: a) providing a surface...
8642744 Crosslinking reagent for analysis of protein-protein interaction  
Crosslinking reagents and methods for using the same for analysis of protein-protein interactions, are provided. The crosslinking reagents include a trifunctional scaffold that links two protein...
8642308 Biofuel cell electrocatalysts utilizing enzyme-carbon nanotube adducts  
The present disclosure provides multi-walled carbon nanotubes and carbon nanotubes (CNTs) displaying catalytic enzymes bound to the nanotube sidewalls and devices, such as electrodes,...
8580545 Biodegradable linkers for molecular therapies  
A method and a composition for delivery of a biomaterial to an animal cell or a tissue, the composition includes (a) a biomaterial; (b) a biodegradable cross-linker portion having a hydrolyzable...
8563245 Method for changing surface properties of a substrate from immobilized biomolecules  
A method that modifies surface properties of a substrate by manipulating the immobilized biomolecules in mild biological condition. The manipulation comprised steps of: providing a biomolecule...
8546493 Multi-armed, monofunctional, and hydrolytically stable derivatives of poly(ethylene glycol) and related polymers for modification of surfaces and molecules  
Multi-armed, monofunctional, and hydrolytically stable polymers are described having the structure wherein Z is a moiety that can be activated for attachment to biologically active molecules such...
8530212 Carbene precursor compound for producing an adhesive surface on a substrate  
A process for producing a substrate having an adhesive surface, which process comprises: (a) contacting the substrate with a carbene precursor, which carbene precursor is a compound of the...
8512728 Method of forming a medical device on biological tissue  
A method for in situ formation of a medical device on biological tissue includes attaching a plurality of reactive members of a primary specific binding pair to a surface of the biological tissue,...
8507255 Coating system comprising synzyme for degradation of threat agents  
Sorption reinforced catalytic coating system for the degradation of threat agents including a synzyme coating about a material configured for the degradation of the threat agents, the synzyme...
8507256 Sorption reinforced catalytic coating system and method for the degradation of threat agents  
Sorption reinforced catalytic coating system for the degradation of threat agents including a synzyme coating about a material, the synzyme coating having bucket-shaped molecules for the sorption...
8497357 Degradable heterobifunctional poly(ethylene glycol) acrylates and gels and conjugates derived therefrom  
A heterobifunctional poly(ethylene glycol) is provided having a hydrolytically degradable linkage, a first terminus comprising an acrylate group, and a second terminus comprising a target such as...
8440441 Method of preparing a substrate for immobilization of functional substances thereon and the substrate obtained therefrom  
A substrate having compounds disposed thereon for immobilizing a functional molecule, each compound having a chain comprising: a moiety R that is chemically coupled to the substrate, said moiety R...
8440816 Branched polymers  
The present invention is directed to branched reactive water-soluble polymers comprising at least two polymer arms, such as poly(ethylene glycol), attached to a central aliphatic hydrocarbon core...
8394951 Protein kinase C inhibitors and uses thereof  
This disclosure concerns compounds which are useful as inhibitors of protein kinase C (PKC) and are thus useful for treating a variety of diseases and disorders that are mediated or sustained...
8383380 Segmented polymers and their conjugates  
Segmented water soluble polymers, containing a higher molecular weight segment linked to a lower molecular weight segment, are described. In one embodiment, the polymer segments are poly(ethylene...
RE43979 Method for detection of specific target cells in specialized or mixed cell population and solutions containing mixed cell populations  
The invention relates to a method for detecting specific target-cells in a simple and time saving way, using paramagnetic particles, antibodies recognizing the Fc portions of target-cell...
8354477 Multi-armed, monofunctional, and hydrolytically stable derivatives of poly(ethylene glycol) and related polymers for modification of surfaces and molecules  
Multi-armed, monofunctional, and hydrolytically stable polymers are described having the structure wherein Z is a moiety that can be activated for attachment to biologically active molecules such...
8236153 Immobilization support, process for producing the same, electrode, process for producing the same, electrode reaction utilizing apparatus and process for producing the same  
An immobilization carrier containing an electron acceptor compound is used in addition to glutaraldehyde and poly-L-lysine to immobilize an enzyme and an electron acceptor compound simultaneously...
8148123 Methods for lowering elevated uric acid levels using intravenous injections of PEG-uricase  
A method for lowering elevated uric acid levels in patients is disclosed and consists of administering to the patients an intravenous injection of PEG-uricase having a dosage from about 4 to about...
8137942 Method of preparing a modified surface  
Reactive surfaces, substrates and methods of producing and using such substrates and surfaces are provided. The substrates and surfaces provide low density reactive groups preferably on an...
8084435 Biodegradable linkers for molecular therapies  
A method and a composition for delivery of a biomaterial to an animal cell or a tissue, the composition includes (a) a biomaterial; (b) a biodegradable cross-linker portion having a hydrolyzable...
8067174 Polymerase chain reaction (PCR) method for amplifying a DNA template  
The present invention relates to a DNA polymerase immobilized by covalent bonding. More particularly, the present invention relates to an immobilized DNA polymerase whose activity is maximally...
8007784 Antigenic modulation of cells  
The present invention is directed to a non-immunogenic cellular composition comprising: a cell having a cell surface and antigenic determinants on the cell surface; an optional linker molecule...
7927589 PEG-urate oxidase conjugates and use thereof  
A naturally occurring or recombinant urate oxidase (uricase) covalently coupled to poly(ethylene glycol) or poly(ethylene oxide) (both referred to as PEG), wherein an average of 2 to 10 strands of...
7892805 Method of enhancing enzyme activity and enzyme solution having enhanced activity  
A method of enhancing the intrinsic activity of an enzyme in a raw enzyme solution, the method comprising treating the raw enzyme solution with an effective amount of a purifying agent, most...
7811800 Variant form of urate oxidase and use thereof  
The present invention relates to genetically modified proteins with uricolytic activity. More specifically, the invention relates to proteins comprising truncated urate oxidases and methods for...
7785660 Preparation of polymer particles  
A process for the preparation of polymer magnetic particles, which comprises: providing polymer particles having a porous interior, and contacting the polymer particles with a magnetic fluid...
7777023 Method for the chemical synthesis of oligonucleotides  
The present invention features novel compositions, linkers, derivatized solid supports, and methods for the efficient solid phase synthesis of oligonucleotides, including RNA, DNA, RNA-DNA...
7763423 Substrates having low density reactive groups for monitoring enzyme activity  
Reactive surfaces, substrates and methods of producing and using such substrates and surfaces are provided. The substrates and surfaces provide low density reactive groups preferably on an...
7700334 Photoswitchable method for the ordered attachment of proteins to surfaces  
Described herein is a method for the attachment of proteins to any solid support with control over the orientation of the attachment. The method is extremely efficient, not requiring the previous...
7695973 Determination of glycated protein  
The present invention provides methods for quantitation of glycated protein in a biological sample using a solid support matrix by making a first bound protein measurement total bound protein...
7632618 Polyhydroxyalkanoate-containing structure and manufacturing method thereof  
A method for manufacturing polyhydroxyalkanoate-containing structure, at least a part of a base material surface of the structure being coated with polyhydroxyalkanoate, the method comprises the...
7575935 Retentate chromatography and protein chip arrays with applications in biology and medicine  
This invention provides methods of retentate chromatography for resolving analytes in a sample. The methods involve adsorbing the analytes to a substrate under a plurality of different selectivity...
7544438 Electron mediator, electron mediator immobilized electrode, and biofuel cell using the electrode  
An object of the present invention is to provide a highly functional mediator capable of smoothly proceeding electron transfer between an electrode and a biocatalyst based on the premise that the...
7531334 Polymeric microcarriers for cell culture functions  
Polymeric microcarriers suitable for use in cell culture processes and the methods of making such polymeric microcarriers by emulsion/aggregation polymerization processes.
7520970 Immobilization support, process for producing the same, electrode, process for producing the same, electrode reaction utilizing apparatus and process for producing the same  
An immobilization carrier containing an electron acceptor compound is used in addition to glutaraldehyde and poly-L-lysine to immobilize an enzyme and an electron acceptor compound simultaneously...
7520912 Air purifying filter media and process for producing the same  
It is intended to provide an air purification filter which has a high dry tensile strength, a high wet tensile strength in association with a high water resistance and a high water repellency and...
7514540 Functionalized carrier material containing covalently bound biomolecule via a linker  
The invention concerns a method for immobilizing biomolecules on a polymeric surface of a carrier material and a carrier material functionalized with a biomolecule according to the general...
7514067 Methods for tumor diagnosis and therapy  
The present invention discloses a method for the enzyme-mediated, site-specific, in-vivo precipitation of a water soluble molecule in an animal. The enzyme is either unique to tumor cells, or is...
7494824 Interactive system for presenting and eliminating substances  
An interactive system is provided with at least one active surface of plastic from monomers containing at least one structural element derived from a carbon dioxide (A), and at least one substance...
7439062 Beads for capturing target cells from bodily fluid  
Spheroidal beads present an exterior surface of a hydrophilic hydrogel, which is an isocyanate-functional polymer that is polymerized by urethane bonds and cross-linked by urethane and urea bonds....
7427497 In vitro metabolic engineering on microscale devices  
Disclosed herein is a microfluidics device that can be used to prepare natural products and their analogs. The device comprises the enzymes of a biosynthetic pathway immobilized thereon and a...